psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E103	R:R:Y47	4.49	No	No	0	6	4
2	R:R:F107	R:R:Y47	4.13	No	No	0	5	4
3	R:R:T48	R:R:W49	4.85	No	No	0	1	5
4	R:R:F107	R:R:V51	7.87	No	No	0	5	5
5	R:R:I53	R:R:L301	8.56	No	No	0	5	5
6	R:R:L100	R:R:L54	5.54	No	No	0	8	7
7	R:R:I57	R:R:L305	4.28	No	No	0	7	4
8	R:R:F58	R:R:V62	3.93	Yes	No	0	7	5
9	R:R:F58	R:R:L96	3.65	Yes	No	0	7	8
10	R:R:F58	R:R:S97	2.64	Yes	No	0	7	6
11	R:R:F58	R:R:L100	3.65	Yes	No	0	7	8
12	R:R:N61	R:R:N65	10.9	Yes	Yes	3	9	9
13	R:R:N61	R:R:S93	8.94	Yes	No	3	9	9
14	R:R:N61	R:R:Y128	3.49	Yes	Yes	0	9	9
15	R:R:A308	R:R:N61	4.69	No	Yes	0	7	9
16	R:R:C90	R:R:N65	9.45	No	Yes	0	8	9
17	R:R:N65	R:R:S93	4.47	Yes	No	3	9	9
18	R:R:N65	R:R:P311	3.26	Yes	No	0	9	9
19	R:R:I71	R:R:L67	2.85	Yes	No	0	6	7
20	R:R:C90	R:R:V68	3.42	No	No	0	8	9
21	R:R:S315	R:R:V68	3.23	No	No	0	7	9
22	R:R:C90	R:R:T69	3.38	No	No	0	8	6
23	R:R:K74	R:R:Y70	10.75	No	No	4	4	4
24	R:R:L328	R:R:Y70	8.21	No	No	4	6	4
25	R:R:F321	R:R:I71	8.79	No	Yes	0	8	6
26	R:R:F72	R:R:R76	3.21	No	No	0	6	5
27	R:R:D83	R:R:F72	4.78	No	No	0	7	6
28	R:R:F72	R:R:L87	10.96	No	No	0	6	6
29	R:R:H75	R:R:K74	14.41	No	No	0	4	4
30	R:R:K74	R:R:L328	2.82	No	No	4	4	6
31	R:R:H75	R:R:R324	14.67	No	No	0	4	5
32	R:R:A79	R:R:D83	4.63	No	No	0	5	7
33	R:R:A79	R:R:Q158	3.03	No	No	0	5	3
34	R:R:A81	R:R:V142	3.39	No	No	0	7	9
35	R:R:I82	R:R:L86	2.85	No	No	0	8	7
36	R:R:I82	R:R:V139	3.07	No	No	0	8	8
37	R:R:I82	R:R:V142	6.14	No	No	0	8	9
38	R:R:I84	R:R:Q158	4.12	No	No	0	6	3
39	R:R:I84	R:R:W162	9.4	No	No	0	6	3
40	R:R:I84	R:R:T165	3.04	No	No	0	6	6
41	R:R:L85	R:R:V139	2.98	No	No	0	6	8
42	R:R:L85	R:R:T165	2.95	No	No	0	6	6
43	R:R:I89	R:R:S135	4.64	No	No	0	9	7
44	R:R:I89	R:R:P311	3.39	No	No	0	9	9
45	R:R:N92	R:R:Y128	8.14	No	Yes	0	8	9
46	R:R:C95	R:R:F124	5.59	No	Yes	0	6	4
47	R:R:C95	R:R:L127	3.17	No	Yes	0	6	5
48	R:R:L96	R:R:Y128	11.72	No	Yes	0	8	9
49	R:R:I98	R:R:S97	3.1	No	No	0	4	6
50	R:R:F124	R:R:I98	13.82	Yes	No	0	4	4
51	R:R:E121	R:R:S99	10.06	Yes	No	5	5	7
52	R:R:S99	R:R:Y125	3.82	No	No	5	7	6
53	R:R:A102	R:R:E121	3.02	No	Yes	0	7	5
54	R:R:E103	R:R:E121	12.69	No	Yes	0	6	5
55	R:R:M106	R:R:Q193	2.72	No	Yes	0	6	2
56	R:R:P110	R:R:Q193	7.9	No	Yes	0	4	2
57	R:R:N111	R:R:Q193	5.28	No	Yes	0	9	2
58	R:R:I112	R:R:L117	4.28	No	No	0	3	5
59	R:R:I113	R:R:L117	2.85	No	No	0	8	5
60	R:R:C118	R:R:I113	3.27	No	No	0	9	8
61	R:R:I113	R:R:Q193	4.12	No	Yes	0	8	2
62	R:R:R185	R:R:T115	7.76	No	No	0	5	3
63	R:R:G116	R:R:R119	3	No	No	0	2	8
64	R:R:C118	R:R:R183	2.79	No	No	6	9	6
65	R:R:C118	R:R:C196	7.28	No	No	6	9	9
66	R:R:C180	R:R:R119	4.18	No	No	0	4	8
67	R:R:F124	R:R:L120	4.87	Yes	No	0	4	4
68	R:R:E121	R:R:Y125	3.37	Yes	No	5	5	6
69	R:R:I122	R:R:Y126	7.25	No	No	0	6	5
70	R:R:C180	R:R:I122	3.27	No	No	0	4	6
71	R:R:I122	R:R:R183	12.53	No	No	0	6	6
72	R:R:F123	R:R:F124	5.36	Yes	Yes	0	5	4
73	R:R:F123	R:R:L173	3.65	Yes	No	0	5	3
74	R:R:F123	R:R:S176	2.64	Yes	No	0	5	7
75	R:R:C180	R:R:F123	4.19	No	Yes	0	4	5
76	R:R:V129	R:R:Y125	3.79	No	No	0	7	6
77	R:R:Y126	R:R:Y130	3.97	No	Yes	0	5	8
78	R:R:A179	R:R:Y126	9.34	No	No	0	5	5
79	R:R:L127	R:R:L173	4.15	Yes	No	0	5	3
80	R:R:L127	R:R:S176	3	Yes	No	0	5	7
81	R:R:S307	R:R:Y128	8.9	No	Yes	0	8	9
82	R:R:V129	R:R:Y130	3.79	No	Yes	0	7	8
83	R:R:F134	R:R:Y130	3.09	No	Yes	0	6	8
84	R:R:L175	R:R:Y130	4.69	No	Yes	0	5	8
85	R:R:S215	R:R:Y130	3.82	No	Yes	0	6	8
86	R:R:L131	R:R:L169	2.77	No	No	0	7	9
87	R:R:A172	R:R:L131	3.15	No	No	0	7	7
88	R:R:D132	R:R:Y306	3.45	No	Yes	1	9	9
89	R:R:D132	R:R:S307	4.42	No	No	0	9	8
90	R:R:D132	R:R:V310	8.76	No	Yes	1	9	9
91	R:R:I133	R:R:P223	3.39	No	No	0	8	9
92	R:R:F260	R:R:I133	5.02	Yes	No	0	9	8
93	R:R:F134	R:R:I171	7.54	No	No	0	6	4
94	R:R:L227	R:R:V136	4.47	No	No	0	8	8
95	R:R:V136	R:R:Y314	6.31	No	No	0	8	9
96	R:R:L226	R:R:V137	4.47	No	No	0	6	7
97	R:R:C138	R:R:L164	3.17	No	No	0	6	5
98	R:R:R143	R:R:V139	5.23	No	No	0	9	8
99	R:R:L227	R:R:S140	3	No	No	0	8	9
100	R:R:F230	R:R:S140	5.28	Yes	No	0	8	9
101	R:R:S140	R:R:Y231	6.36	No	Yes	0	9	9
102	R:R:L141	R:R:L145	4.15	No	No	0	5	6
103	R:R:F230	R:R:L141	8.53	Yes	No	0	8	5
104	R:R:L146	R:R:V142	2.98	No	No	0	7	9
105	R:R:R143	R:R:Y231	5.14	No	Yes	0	9	9
106	R:R:R143	R:R:Y314	3.09	No	No	0	9	9
107	R:R:A148	R:R:Y144	5.34	No	Yes	0	7	8
108	R:R:F230	R:R:Y144	5.16	Yes	Yes	0	8	8
109	R:R:L233	R:R:Y144	8.21	No	Yes	0	4	8
110	R:R:T234	R:R:Y144	3.75	No	Yes	0	8	8
111	R:R:L145	R:R:W154	3.42	No	Yes	0	6	5
112	R:R:L146	R:R:P155	4.93	No	No	0	7	3
113	R:R:T234	R:R:V147	4.76	No	No	0	8	8
114	R:R:A148	R:R:Y149	4	No	No	0	7	6
115	R:R:W154	R:R:Y149	3.86	Yes	No	0	5	6
116	R:R:R152	R:R:T151	3.88	No	No	0	4	5
117	R:R:R152	R:R:W154	3	No	Yes	0	4	5
118	R:R:P155	R:R:W154	9.46	No	Yes	0	3	5
119	R:R:L160	R:R:L164	4.15	No	No	0	3	5
120	R:R:G161	R:R:L164	3.42	No	No	0	7	5
121	R:R:A218	R:R:L175	3.15	No	No	0	4	5
122	R:R:D178	R:R:R181	9.53	No	No	7	8	4
123	R:R:D178	R:R:H182	6.3	No	No	7	8	5
124	R:R:D178	R:R:H210	7.56	No	No	0	8	3
125	R:R:H182	R:R:R181	3.39	No	No	7	5	4
126	R:R:H182	R:R:V211	8.3	No	No	0	5	5
127	R:R:C196	R:R:R183	6.96	No	No	6	9	6
128	R:R:R185	R:R:V187	6.54	No	No	0	5	2
129	R:R:D188	R:R:V186	4.38	No	No	0	1	1
130	R:R:K192	R:R:V187	10.62	No	No	0	5	2
131	R:R:D188	R:R:P189	4.83	No	No	0	1	2
132	R:R:E198	R:R:Y197	4.49	No	No	0	5	4
133	R:R:N199	R:R:Y197	3.49	No	No	0	4	4
134	R:R:E198	R:R:R208	4.65	No	Yes	0	5	4
135	R:R:N199	R:R:W207	3.39	No	Yes	0	4	4
136	R:R:T204	R:R:W207	8.49	No	Yes	0	3	4
137	R:R:A205	R:R:D206	3.09	No	No	0	1	1
138	R:R:R208	R:R:W207	13.99	Yes	Yes	2	4	4
139	R:R:R278	R:R:W207	11	No	Yes	2	4	4
140	R:R:L209	R:R:R208	15.79	No	Yes	0	2	4
141	R:R:R208	R:R:R212	5.33	Yes	Yes	2	4	5
142	R:R:R208	R:R:T275	3.88	Yes	No	2	4	5
143	R:R:R208	R:R:R278	8.53	Yes	No	2	4	4
144	R:R:R208	R:R:R279	7.46	Yes	No	2	4	3
145	R:R:L209	R:R:T213	2.95	No	No	0	2	4
146	R:R:H210	R:R:V214	6.92	No	No	0	3	4
147	R:R:N271	R:R:R212	14.46	No	Yes	0	5	5
148	R:R:D274	R:R:R212	3.57	No	Yes	0	5	5
149	R:R:R212	R:R:T275	10.35	Yes	No	2	5	5
150	R:R:H268	R:R:V216	5.54	No	No	0	9	5
151	R:R:G219	R:R:P223	4.06	No	No	0	7	9
152	R:R:F220	R:R:F260	5.36	Yes	Yes	1	9	9
153	R:R:F220	R:R:F261	6.43	Yes	No	1	9	5
154	R:R:C264	R:R:F220	2.79	No	Yes	1	9	9
155	R:R:F220	R:R:F265	8.57	Yes	No	1	9	5
156	R:R:F220	R:R:H268	9.05	Yes	No	0	9	9
157	R:R:F260	R:R:L224	3.65	Yes	No	0	9	6
158	R:R:F261	R:R:L224	4.87	No	No	0	5	6
159	R:R:L229	R:R:L233	4.15	No	No	0	4	4
160	R:R:I253	R:R:Y231	12.09	No	Yes	0	7	9
161	R:R:V256	R:R:Y231	3.79	No	Yes	0	7	9
162	R:R:V238	R:R:W235	4.9	No	Yes	0	8	5
163	R:R:R239	R:R:W235	4	No	Yes	0	4	5
164	R:R:V249	R:R:W235	3.68	No	Yes	0	6	5
165	R:R:R250	R:R:W235	9	No	Yes	0	6	5
166	R:R:L243	R:R:T241	7.37	No	No	0	3	6
167	R:R:I253	R:R:V249	3.07	No	No	0	7	6
168	R:R:L317	R:R:V252	2.98	No	No	0	6	6
169	R:R:I313	R:R:L259	2.85	No	No	0	8	6
170	R:R:C264	R:R:F260	5.59	No	Yes	1	9	9
171	R:R:F260	R:R:Y306	6.19	Yes	Yes	1	9	9
172	R:R:F261	R:R:F265	3.22	No	No	1	5	5
173	R:R:F263	R:R:V262	3.93	No	No	0	8	4
174	R:R:F263	R:R:Y306	11.35	No	Yes	0	8	9
175	R:R:C264	R:R:Y306	2.69	No	Yes	1	9	9
176	R:R:F265	R:R:V269	7.87	No	No	0	5	5
177	R:R:N271	R:R:Y267	17.44	No	Yes	0	5	7
178	R:R:T299	R:R:Y267	7.49	No	Yes	0	8	7
179	R:R:Q303	R:R:Y267	13.53	No	Yes	0	8	7
180	R:R:H268	R:R:Q303	3.71	No	No	0	9	8
181	R:R:L270	R:R:L273	2.77	No	No	0	5	6
182	R:R:L270	R:R:T299	2.95	No	No	0	5	8
183	R:R:L296	R:R:N271	4.12	No	No	0	4	5
184	R:R:I292	R:R:L273	5.71	Yes	No	0	5	6
185	R:R:D274	R:R:I292	7	No	Yes	0	5	5
186	R:R:D274	R:R:L296	5.43	No	No	0	5	4
187	R:R:L276	R:R:W281	4.56	No	No	0	5	2
188	R:R:I282	R:R:L276	2.85	No	No	0	3	5
189	R:R:R278	R:R:R279	4.26	No	No	2	4	3
190	R:R:D284	R:R:R283	4.76	No	No	0	1	2
191	R:R:C286	R:R:D284	3.11	No	No	0	8	1
192	R:R:I292	R:R:T288	3.04	Yes	No	0	5	3
193	R:R:G290	R:R:R289	3	No	No	0	3	3
194	R:R:L305	R:R:V309	2.98	No	No	0	4	6
195	R:R:V310	R:R:Y306	3.79	Yes	Yes	1	9	9
196	R:R:I313	R:R:V309	3.07	No	No	0	8	6
197	R:R:P311	R:R:V310	5.3	No	Yes	0	9	9
198	R:R:V310	R:R:Y314	3.79	Yes	No	0	9	9
199	R:R:C316	R:R:L312	3.17	No	No	0	7	6
200	R:R:F321	R:R:S315	9.25	No	No	0	8	7
201	R:R:R322	R:R:S319	3.95	No	No	0	8	5
202	R:R:F107	R:R:V104	2.62	No	No	0	5	7
203	R:R:R246	R:R:T241	2.59	No	No	0	7	6
204	R:R:S300	R:R:Y267	2.54	No	Yes	0	7	7
205	R:R:V257	R:R:Y231	2.52	No	Yes	0	7	9
206	R:R:I71	R:R:R324	2.51	Yes	No	0	6	5
207	R:R:M337	R:R:R333	2.48	No	No	0	5	4
208	R:R:F230	R:R:L226	2.44	Yes	No	0	8	6
209	R:R:F263	R:R:L259	2.44	No	No	0	8	6
210	R:R:L320	R:R:R324	2.43	No	No	0	6	5
211	R:R:M325	R:R:Y326	2.39	No	No	0	5	4
212	R:R:K157	R:R:W154	2.32	No	Yes	0	6	5
213	R:R:F329	R:R:R333	2.14	No	No	0	5	4
214	R:R:A81	R:R:G161	1.95	No	No	0	7	7
215	R:R:A200	R:R:G201	1.95	No	No	0	5	5
216	R:R:A340	R:R:G339	1.95	No	No	0	5	5
217	R:R:G52	R:R:S55	1.86	No	No	0	5	6
218	R:R:G339	R:R:S338	1.86	No	No	0	5	8
219	R:R:G52	R:R:V51	1.84	No	No	0	5	5
220	R:R:G295	R:R:V294	1.84	No	No	0	6	3
221	R:R:G66	R:R:T69	1.82	No	No	0	3	6
222	R:R:G88	R:R:T165	1.82	No	No	0	9	6
223	R:R:G116	R:R:T115	1.82	No	No	0	2	3
224	R:R:P266	R:R:T299	1.75	No	No	0	9	8
225	R:R:G64	R:R:L63	1.71	No	No	0	8	3
226	R:R:G64	R:R:L312	1.71	No	No	0	8	6
227	R:R:A168	R:R:S135	1.71	No	No	0	6	7
228	R:R:G295	R:R:L270	1.71	No	No	0	6	5
229	R:R:G201	R:R:N202	1.7	No	No	0	5	3
230	R:R:K156	R:R:P155	1.67	No	No	0	7	3
231	R:R:L222	R:R:P223	1.64	No	No	0	6	9
232	R:R:G327	R:R:Q330	1.64	No	No	0	4	5
233	R:R:A194	R:R:M106	1.61	No	No	0	4	6
234	R:R:V147	R:R:V237	1.6	No	No	0	8	6
235	R:R:S150	R:R:T151	1.6	No	No	0	7	5
236	R:R:V252	R:R:V256	1.6	No	No	0	6	7
237	R:R:T217	R:R:V216	1.59	No	No	0	4	5
238	R:R:T241	R:R:V238	1.59	No	No	0	6	8
239	R:R:A304	R:R:L54	1.58	No	No	0	7	7
240	R:R:A172	R:R:L127	1.58	No	Yes	0	7	5
241	R:R:I60	R:R:V309	1.54	No	No	0	5	6
242	R:R:I228	R:R:V257	1.54	No	No	0	4	7
243	R:R:L117	R:R:S114	1.5	No	No	0	5	7
244	R:R:G251	R:R:R250	1.5	No	No	0	5	6
245	R:R:L301	R:R:S300	1.5	No	No	0	5	7
246	R:R:L63	R:R:V62	1.49	No	No	0	3	5
247	R:R:L312	R:R:V68	1.49	No	No	0	6	9
248	R:R:L105	R:R:V104	1.49	No	No	0	4	7
249	R:R:L175	R:R:V214	1.49	No	No	0	5	4
250	R:R:L258	R:R:V254	1.49	No	No	0	4	4
251	R:R:L258	R:R:V262	1.49	No	No	0	4	4
252	R:R:I71	R:R:M325	1.46	Yes	No	0	6	5
253	R:R:G327	R:R:Y326	1.45	No	No	0	4	4
254	R:R:F109	R:R:P110	1.44	No	No	0	4	4
255	R:R:Q193	R:R:S191	1.44	Yes	No	0	2	3
256	R:R:Q323	R:R:S319	1.44	No	No	0	4	5
257	R:R:Q334	R:R:S338	1.44	No	No	0	6	8
258	R:R:I171	R:R:L170	1.43	No	No	0	4	3
259	R:R:I282	R:R:L277	1.43	No	No	0	3	3
260	R:R:I292	R:R:L277	1.43	Yes	No	0	5	3
261	R:R:D206	R:R:M203	1.39	No	No	0	1	3
262	R:R:L301	R:R:N50	1.37	No	No	0	5	4
263	R:R:D284	R:R:L277	1.36	No	No	0	1	3
264	R:R:R185	R:R:S184	1.32	No	No	0	5	4
265	R:R:R240	R:R:V237	1.31	No	No	0	4	6
266	R:R:V186	R:R:Y197	1.26	No	No	0	1	4
267	R:R:F109	R:R:L108	1.22	No	No	0	4	4
268	R:R:Q334	R:R:R333	1.17	No	No	0	6	4
269	R:R:R322	R:R:Y326	1.03	No	No	0	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F58	3.4675	4	0	7
2	R:R:N61	7.005	4	3	9
3	R:R:N65	7.02	4	3	9
4	R:R:I71	3.9025	4	0	6
5	R:R:E121	7.285	4	5	5
6	R:R:F123	3.96	4	0	5
7	R:R:F124	7.41	4	0	4
8	R:R:L127	2.975	4	0	5
9	R:R:Y128	8.0625	4	0	9
10	R:R:Y130	3.872	5	0	8
11	R:R:Y144	5.615	4	0	8
12	R:R:W154	4.412	5	0	5
13	R:R:Q193	4.292	5	0	2
14	R:R:W207	9.2175	4	2	4
15	R:R:R208	8.51857	7	2	4
16	R:R:R212	8.4275	4	2	5
17	R:R:F220	6.44	5	1	9
18	R:R:F230	5.3525	4	0	8
19	R:R:Y231	5.98	5	0	9
20	R:R:W235	5.395	4	0	5
21	R:R:F260	5.162	5	1	9
22	R:R:Y267	10.25	4	0	7
23	R:R:I292	4.295	4	0	5
24	R:R:Y306	5.494	5	1	9
25	R:R:V310	5.41	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E103	R:R:E121	10.4096	12.69	No	Yes	0	6	5
2	R:R:E121	R:R:Y125	12.8984	3.37	Yes	No	5	5	6
3	R:R:V129	R:R:Y125	15.4331	3.79	No	No	0	7	6
4	R:R:V129	R:R:Y130	16.6698	3.79	No	Yes	0	7	8
5	R:R:Y126	R:R:Y130	32.0266	3.97	No	Yes	0	5	8
6	R:R:I122	R:R:Y126	34.2787	7.25	No	No	0	6	5
7	R:R:C180	R:R:I122	51.1623	3.27	No	No	0	4	6
8	R:R:C180	R:R:F123	58.8884	4.19	No	Yes	0	4	5
9	R:R:F123	R:R:F124	59.9725	5.36	Yes	Yes	0	5	4
10	R:R:F124	R:R:I98	66.9122	13.82	Yes	No	0	4	4
11	R:R:I98	R:R:S97	67.752	3.1	No	No	0	4	6
12	R:R:F58	R:R:S97	68.5842	2.64	Yes	No	0	7	6
13	R:R:F58	R:R:L96	67.7978	3.65	Yes	No	0	7	8
14	R:R:L96	R:R:Y128	68.5536	11.72	No	Yes	0	8	9
15	R:R:S307	R:R:Y128	68.0803	8.9	No	Yes	0	8	9
16	R:R:D132	R:R:S307	68.6224	4.42	No	No	0	9	8
17	R:R:D132	R:R:Y306	43.7607	3.45	No	Yes	1	9	9
18	R:R:F260	R:R:Y306	57.3768	6.19	Yes	Yes	1	9	9
19	R:R:F220	R:R:F260	53.2695	5.36	Yes	Yes	1	9	9
20	R:R:F220	R:R:H268	100	9.05	Yes	No	0	9	9
21	R:R:H268	R:R:Q303	95.74	3.71	No	No	0	9	8
22	R:R:Q303	R:R:Y267	94.3047	13.53	No	Yes	0	8	7
23	R:R:C264	R:R:Y306	52.59	2.69	No	Yes	1	9	9
24	R:R:C264	R:R:F220	52.0403	2.79	No	Yes	1	9	9
25	R:R:F263	R:R:Y306	12.8603	11.35	No	Yes	0	8	9
26	R:R:C90	R:R:N65	24.0676	9.45	No	Yes	0	8	9
27	R:R:N65	R:R:P311	27.3734	3.26	Yes	No	0	9	9
28	R:R:S315	R:R:V68	21.2314	3.23	No	No	0	7	9
29	R:R:F321	R:R:S315	20.0405	9.25	No	No	0	8	7
30	R:R:F321	R:R:I71	18.8419	8.79	No	Yes	0	8	6
31	R:R:D132	R:R:V310	25.5831	8.76	No	Yes	1	9	9
32	R:R:V310	R:R:Y314	86.5672	3.79	Yes	No	0	9	9
33	R:R:R143	R:R:Y314	64.37	3.09	No	No	0	9	9
34	R:R:R143	R:R:V139	30.2668	5.23	No	No	0	9	8
35	R:R:L85	R:R:V139	13.0969	2.98	No	No	0	6	8
36	R:R:L85	R:R:T165	11.9441	2.95	No	No	0	6	6
37	R:R:I82	R:R:V142	15.4941	6.14	No	No	0	8	9
38	R:R:I82	R:R:V139	17.67	3.07	No	No	0	8	8
39	R:R:I122	R:R:R183	19.0556	12.53	No	No	0	6	6
40	R:R:C118	R:R:R183	16.6164	2.79	No	No	6	9	6
41	R:R:C118	R:R:I113	15.4331	3.27	No	No	0	9	8
42	R:R:I113	R:R:Q193	10.4096	4.12	No	Yes	0	8	2
43	R:R:L175	R:R:Y130	10.4096	4.69	No	Yes	0	5	8
44	R:R:V136	R:R:Y314	21.9682	6.31	No	No	0	8	9
45	R:R:L227	R:R:V136	20.991	4.47	No	No	0	8	8
46	R:R:L227	R:R:S140	20.1473	3	No	No	0	8	9
47	R:R:F230	R:R:S140	39.9168	5.28	Yes	No	0	8	9
48	R:R:R143	R:R:Y231	38.012	5.14	No	Yes	0	9	9
49	R:R:S140	R:R:Y231	22.2239	6.36	No	Yes	0	9	9
50	R:R:F230	R:R:L141	14.8643	8.53	Yes	No	0	8	5
51	R:R:L141	R:R:L145	12.7839	4.15	No	No	0	5	6
52	R:R:F230	R:R:Y144	19.0594	5.16	Yes	Yes	0	8	8
53	R:R:L145	R:R:W154	10.757	3.42	No	Yes	0	6	5
54	R:R:R208	R:R:R212	22.8461	5.33	Yes	Yes	2	4	5
55	R:R:N271	R:R:R212	42.2415	14.46	No	Yes	0	5	5
56	R:R:N271	R:R:Y267	62.2514	17.44	No	Yes	0	5	7
57	R:R:D274	R:R:R212	17.6127	3.57	No	Yes	0	5	5
58	R:R:D274	R:R:L296	16.9027	5.43	No	No	0	5	4
59	R:R:L296	R:R:N271	18.5479	4.12	No	No	0	4	5
60	R:R:I253	R:R:Y231	11.9823	12.09	No	Yes	0	7	9
61	R:R:I253	R:R:V249	10.818	3.07	No	No	0	7	6
62	R:R:T299	R:R:Y267	25.4457	7.49	No	Yes	0	8	7
63	R:R:L270	R:R:T299	22.056	2.95	No	No	0	5	8
64	R:R:L270	R:R:L273	17.1165	2.77	No	No	0	5	6
65	R:R:D274	R:R:I292	31.0417	7	No	Yes	0	5	5
66	R:R:I292	R:R:L273	15.517	5.71	Yes	No	0	5	6
67	R:R:I292	R:R:L277	35.9011	1.43	Yes	No	0	5	3
68	R:R:I282	R:R:L277	15.4331	1.43	No	No	0	3	3
69	R:R:I282	R:R:L276	10.2951	2.85	No	No	0	3	5
70	R:R:D284	R:R:L277	15.4331	1.36	No	No	0	1	3
71	R:R:V310	R:R:Y306	68.7254	3.79	Yes	Yes	1	9	9
72	R:R:P311	R:R:V310	29.4957	5.3	No	Yes	0	9	9
73	R:R:C90	R:R:V68	20.6779	3.42	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8K4P_nogp

PDB Summary
PDB	8K4P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	252
Number of Links	269
Number of Hubs	25
Number of Links mediated by Hubs	101
Number of Communities	7
Number of Nodes involved in Communities	29
Number of Links involved in Communities	34

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	50342
Length Of Smallest Path	3
Average Path Length	17.1984
Length of Longest Path	36
Minimum Path Strength	1.24
Average Path Strength	5.65747
Maximum Path Strength	15.95
Minimum Path Correlation	0.7
Average Path Correlation	0.938075
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.6112
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.6734
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • positive regulation of cytosolic calcium ion concentration • cell chemotaxis • chemotaxis • response to external stimulus • taxis • locomotion • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • immune response • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q76SF8
Sequence	>8K4P_nogp_Chain_R Y T W N V G I L S L I F L I N V L G N G L V T Y I F C K H R S R A G A I D I L L L G I C L N S L C L S I S L L A E V L M F L F P N I I S T G L C R L E I F F Y Y L Y V Y L D I F S V V C V S L V R Y L L V A Y S T R S W P K K Q S L G W V L T S A A L L I A L V L S G D A C R H R S R V V D P V S K Q A M C Y E N A G N M T A D W R L H V R T V S V T A G F L L P L A L L I L F Y A L T W C V V R R T K L Q A R R K V R G V I V A V V L L F F V F C F P Y H V L N L L D T L L R R R W I R D S C Y T R G L I N V G L A V T S L L Q A L Y S A V V P L I Y S C L G S L F R Q R M Y G L F Q S L R Q S F M S G A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8K4O	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	CXCL1	-	Gi1/β1/γ1	3.01	2024-07-24	doi.org/10.1073/pnas.2403217121
	8K4O (No Gprot)	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	CXCL1	-		3.01	2024-07-24	doi.org/10.1073/pnas.2403217121
	8K4P	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	-	-	Gi1/β1/γ1	2.81	2024-07-24	doi.org/10.1073/pnas.2403217121
	8K4P (No Gprot)	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	-	-		2.81	2024-07-24	doi.org/10.1073/pnas.2403217121

there is no ligand in network 8K4P_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.