Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L7 3.32408
2B:B:L30 3.975405
3B:B:I33 2.335403
4B:B:T34 4.85435
5B:B:I37 3.682532
6B:B:V40 3.91833633
7B:B:H54 8.48629
8B:B:Y59 8.54518
9B:B:M61 4.005426
10B:B:W63 5.67627
11B:B:I80 8.2775428
12B:B:I81 3.93477
13B:B:W82 8.42571729
14B:B:N88 4.81407
15B:B:K89 4.88857729
16B:B:I93 5.0475477
17B:B:L95 4.556578
18B:B:W99 7.52286719
19B:B:Y105 4.12833606
20B:B:Y111 5.626504
21B:B:N119 4.185409
22B:B:I123 2.684196
23B:B:Y124 5.178576
24B:B:L126 4.185405
25B:B:T128 5.1925403
26B:B:V133 5.715474
27B:B:L139 6.2025409
28B:B:H142 6.388519
29B:B:Y145 5.16875818
30B:B:F151 4.582509
31B:B:T159 5.72419
32B:B:D163 7.805419
33B:B:L168 3.464556
34B:B:W169 8.16718
35B:B:F180 7.96557
36B:B:H183 6.46143759
37B:B:D186 4.628519
38B:B:V200 5.23446
39B:B:C204 5.35517
40B:B:D205 6.055459
41B:B:K209 10.6075456
42B:B:L210 3.1275405
43B:B:W211 8.16333658
44B:B:D212 5.32254169
45B:B:Q220 6.395447
46B:B:F222 7.775448
47B:B:H225 9.21549
48B:B:D228 6.8075419
49B:B:I232 4.785448
50B:B:F235 5.08536
51B:B:P236 5.6675437
52B:B:F241 6.596546
53B:B:T243 5.195448
54B:B:R251 11.048548
55B:B:F253 7.198546
56B:B:D254 4.64509
57B:B:D258 6.485447
58B:B:M262 5.08404
59B:B:Y264 5.516505
60B:B:F278 3.744537
61B:B:R283 5.496539
62B:B:L284 3.99405
63B:B:Y289 7.077107
64B:B:D290 8.21406
65B:B:N295 7.245106
66B:B:W297 5.0654108
67B:B:D298 6.9439
68B:B:L300 5.3575436
69B:B:K301 5.82435
70B:B:H311 8.0665119
71B:B:L318 3.32506
72B:B:M325 6.26405
73B:B:V327 3.0375406
74B:B:W332 10.1929719
75B:B:D333 7.39754119
76B:B:L336 4.22627
77B:B:W339 8.7454119
78R:R:F58 3.4675407
79R:R:N61 7.0054209
80R:R:N65 7.024209
81R:R:I71 3.9025406
82R:R:E121 7.2854225
83R:R:F124 7.41404
84R:R:L127 2.975405
85R:R:Y128 8.0625409
86R:R:Y130 3.872508
87R:R:R143 4.838336249
88R:R:Y144 5.615408
89R:R:W154 4.412505
90R:R:Q193 4.292502
91R:R:W207 9.21754124
92R:R:R208 8.518577124
93R:R:R212 8.42754125
94R:R:F220 6.44589
95R:R:F230 5.3525408
96R:R:Y231 5.98509
97R:R:W235 5.395405
98R:R:F260 5.162589
99R:R:Y267 10.25407
100R:R:I292 4.295405
101R:R:Y306 6.195489
102R:R:V310 5.41489
103A:A:L5 5.6675402
104A:A:V34 5.26595
105A:A:L39 3.7775419
106A:A:K46 5.39409
107A:A:I49 2.44409
108A:A:I184 5.065419
109A:A:F191 7.78593
110A:A:L194 4.285493
111A:A:H195 6.77754174
112A:A:K197 9.0154177
113A:A:M198 4.36406
114A:A:F199 6.525417
115A:A:Q204 4.1675419
116A:A:E207 6.7975418
117A:A:K210 5.71833618
118A:A:W211 4.668519
119A:A:H213 5.5525418
120A:A:F215 4.96667617
121A:A:I221 4.07418
122A:A:I222 2.956508
123A:A:F223 5.7625407
124A:A:Y230 6.73833668
125A:A:D231 6.014568
126A:A:L232 5.205469
127A:A:L234 3.9375465
128A:A:R242 6.8925469
129A:A:F250 5.7885159
130A:A:C254 4.6745158
131A:A:W258 7.56514
132A:A:F259 5.494515
133A:A:I265 2.895406
134A:A:F267 4.5825189
135A:A:F274 6.485466
136A:A:S281 2.835461
137A:A:Y287 7.4445136
138A:A:Y290 9.35754136
139A:A:Y296 6.3025405
140A:A:Y302 11.4454133
141A:A:F307 4.818505
142A:A:N311 5.6365154
143A:A:E318 5.05254147
144A:A:Y320 5.7075405
145A:A:H322 9.94185
146A:A:F323 4.8409
147A:A:T324 7.3554184
148A:A:F336 5.27498
149A:A:K345 4.69754146
150A:A:K349 4.59754149
151A:A:L353 5.09754248
152A:A:F354 6.1625147
153G:G:L19 2.47754299
154G:G:A23 1.9775408
155G:G:Y40 9.955436
156G:G:H44 6.72406
157G:G:D48 5.278509
158G:G:L51 3.1675406
159G:G:V54 4.9275426
160G:G:N59 5.5925429
161G:G:P60 5.5775429
162G:G:F61 4.66833628
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D258 B:B:R22 11.05033.57YesNo076
2G:G:D48 G:G:L51 33.14534.07YesYes096
3G:G:D48 G:G:P49 62.19754.83YesNo097
4B:B:M325 G:G:P49 62.009210.06YesNo057
5B:B:M325 G:G:P60 56.21543.35YesYes059
6B:B:Y85 G:G:P60 52.85019.74NoYes249
7B:B:R68 B:B:Y85 68.029320.58NoNo054
8B:B:D83 B:B:R68 67.640914.29NoNo085
9B:B:D83 B:B:L69 68.07894.07NoNo085
10B:B:L69 B:B:Y105 67.27663.52NoYes056
11B:B:H62 B:B:Y105 53.79654.36NoYes066
12B:B:H62 B:B:R150 53.380914.67NoNo066
13B:B:C148 B:B:R150 52.96492.79NoNo066
14B:B:C148 B:B:L190 51.71433.17NoNo065
15B:B:L190 B:B:V158 40.71934.47NoNo055
16B:B:L168 B:B:V158 38.99062.98YesNo065
17B:B:L168 B:B:V213 37.69122.98YesNo064
18B:B:R214 B:B:V213 37.25993.92NoNo094
19B:B:D212 B:B:R214 35.96344.76YesNo099
20B:B:D212 B:B:L198 32.92374.07YesNo093
21B:B:L198 B:B:L210 32.48772.77NoYes035
22B:B:L210 B:B:Q220 18.55433.99YesYes057
23B:B:D258 B:B:Q220 12.239310.44YesYes477
24B:B:L284 G:G:L51 30.47194.15YesYes056
25B:B:L284 B:B:S279 29.69163YesNo059
26B:B:S279 G:G:D48 29.50288.83NoYes099
27B:B:C294 B:B:L286 30.47943.17NoNo057
28B:B:L286 B:B:V296 60.65354.47NoNo075
29B:B:L284 B:B:V296 60.0915.96YesNo055
30B:B:Y85 G:G:F61 15.57326.19NoYes248
31B:B:C294 B:B:L318 30.2233.17NoYes056
32B:B:L318 B:B:T329 1002.95YesNo068
33B:B:H311 B:B:T329 99.56326.85YesNo098
34B:B:D333 B:B:H311 98.77946.3YesYes1199
35B:B:D333 B:B:F335 98.408410.75YesNo094
36B:B:F335 B:B:R52 97.96497.48NoNo047
37B:B:L286 B:B:V327 30.3732.98NoYes076
38B:B:L318 B:B:V327 34.46022.98YesYes066
39B:B:R52 R:R:R76 97.51957.46NoNo075
40B:B:S316 B:B:W332 27.22964.94NoYes099
41B:B:C317 B:B:S316 27.10095.16NoNo079
42B:B:C317 B:B:M61 26.97886.48NoYes076
43B:B:M61 B:B:W63 18.90983.49YesYes267
44B:B:S84 B:B:W63 16.47944.94NoYes257
45B:B:S84 G:G:F61 16.96565.28NoYes258
46B:B:W332 B:B:Y59 62.24686.75YesYes198
47B:B:Q75 B:B:Y59 62.458315.78NoYes198
48B:B:L126 B:B:Y105 10.6013.52YesYes056
49B:B:Q75 B:B:W99 62.7336.57NoYes199
50A:A:F215 B:B:W99 59.75469.02YesYes179
51A:A:W211 B:B:Y145 16.93924.82YesYes198
52A:A:F215 A:A:W211 19.13064.01YesYes179
53B:B:H142 B:B:S161 10.340813.95YesNo199
54B:B:G162 B:B:S161 11.93853.71NoNo199
55B:B:G162 B:B:Y145 12.00164.35NoYes198
56B:B:F199 B:B:L190 10.64874.87NoNo095
57B:B:L210 B:B:V200 13.13462.98YesYes056
58B:B:C271 B:B:Y289 11.45964.03NoYes1057
59B:B:C271 B:B:D290 12.74524.67NoYes056
60B:B:D290 B:B:R314 47.581920.25YesNo068
61B:B:R314 B:B:W332 47.121816.99NoYes189
62B:B:L318 B:B:S275 42.47164.5YesNo068
63B:B:D290 B:B:T274 42.44222.89YesNo068
64B:B:S275 B:B:T274 42.38074.8NoNo088
65R:R:F72 R:R:R76 97.29693.21NoNo065
66R:R:D83 R:R:F72 96.8494.78NoNo076
67R:R:A79 R:R:D83 96.62444.63NoNo057
68R:R:A79 R:R:Q158 96.39943.03NoNo053
69R:R:I84 R:R:Q158 96.1744.12NoNo063
70R:R:I84 R:R:T165 95.7223.04NoNo066
71R:R:L85 R:R:T165 95.26822.95NoNo066
72R:R:L85 R:R:V139 95.04082.98NoNo068
73R:R:R143 R:R:V139 70.28915.23YesNo098
74R:R:R143 R:R:Y314 62.82013.09YesNo099
75R:R:V310 R:R:Y314 65.57563.79YesNo099
76R:R:D132 R:R:V310 27.0458.76NoYes899
77R:R:D132 R:R:S307 27.90514.42NoNo098
78R:R:S307 R:R:Y128 27.54828.9NoYes089
79R:R:L96 R:R:Y128 26.951611.72NoYes089
80R:R:F58 R:R:L96 26.58413.65YesNo078
81R:R:F58 R:R:S97 24.6282.64YesNo076
82R:R:I98 R:R:S97 24.25643.1NoNo046
83R:R:F124 R:R:I98 23.884413.82YesNo044
84R:R:F123 R:R:F124 20.83625.36NoYes054
85R:R:C180 R:R:F123 20.14094.19NoNo045
86R:R:C180 R:R:I122 17.1163.27NoNo046
87R:R:I122 R:R:Y126 10.98587.25NoNo065
88R:R:Y126 R:R:Y130 10.2123.97NoYes058
89R:R:V310 R:R:Y306 27.86073.79YesYes899
90R:R:F260 R:R:Y306 25.02646.19YesYes899
91R:R:F220 R:R:F260 22.01735.36YesYes899
92R:R:F220 R:R:H268 20.53949.05YesNo099
93R:R:H268 R:R:Q303 19.40823.71NoNo098
94R:R:Q303 R:R:Y267 19.030313.53NoYes087
95R:R:P311 R:R:V310 11.28355.3NoYes099
96R:R:I82 R:R:V139 32.18673.07NoNo088
97R:R:I82 R:R:V142 31.54286.14NoNo089
98R:R:R143 R:R:Y231 11.92475.14YesYes099
99R:R:F230 R:R:S140 11.44435.28YesNo089
100R:R:L146 R:R:V142 29.62352.98NoNo079
101R:R:L146 R:R:P155 29.30324.93NoNo073
102R:R:P155 R:R:W154 27.39159.46NoYes035
103R:R:R152 R:R:W154 30.96633NoYes045
104R:R:R152 R:R:T151 30.55723.88NoNo045
105A:A:L194 R:R:T151 30.14764.42YesNo035
106R:R:N271 R:R:Y267 15.228217.44NoYes057
107R:R:N271 R:R:R212 10.160714.46NoYes055
108A:A:L194 A:A:V34 22.61552.98YesYes935
109A:A:L36 A:A:V34 20.13862.98NoYes075
110A:A:I222 A:A:L36 19.72094.28YesNo087
111A:A:I222 A:A:I265 12.97542.94YesYes086
112A:A:F215 A:A:L37 52.53446.09YesNo179
113A:A:L37 A:A:L39 51.74785.54NoYes199
114A:A:F307 A:A:V225 17.89056.55YesNo057
115A:A:F250 A:A:F307 23.87726.43YesYes095
116A:A:F223 A:A:F250 26.18849.65YesYes079
117A:A:F223 A:A:L39 52.24432.44YesYes079
118A:A:F307 A:A:L266 23.52383.65YesNo058
119A:A:F223 A:A:L266 25.82733.65YesNo078
120A:A:L268 A:A:V225 16.82152.98NoNo097
121A:A:D231 A:A:L232 17.67335.43YesYes689
122A:A:D231 A:A:Y230 12.54339.2YesYes688
123A:A:F274 A:A:Y230 29.41218.25YesYes668
124A:A:F274 A:A:L227 32.33314.87YesNo068
125A:A:L227 A:A:L268 16.65875.54NoNo089
126A:A:K277 A:A:L232 11.80112.82NoYes659
127A:A:K277 A:A:Y230 12.5378.36NoYes658
128A:A:I303 A:A:L227 16.4652.85NoNo068
129A:A:I303 A:A:M243 16.7832.92NoNo069
130A:A:F307 A:A:M243 17.13643.73YesNo059
131A:A:M247 A:A:Y287 11.69938.38NoYes096
132A:A:F307 A:A:M247 12.05543.73YesNo059
133A:A:L232 A:A:R242 18.42368.5YesYes699
134A:A:L234 A:A:R242 12.90823.64YesYes659
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8K4P
Class A
SubFamily Other
Type Unclassified
SubType KSHV
Species Human Gammaherpesvirus 8
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma1
PDB Resolution 2.81
Date 2024-07-24
D.O.I. To be published
Net Summary
Imin 2.79
Number of Linked Nodes 850
Number of Links 1021
Number of Hubs 162
Number of Links mediated by Hubs 601
Number of Communities 29
Number of Nodes involved in Communities 228
Number of Links involved in Communities 316
Path Summary
Number Of Nodes in MetaPath 135
Number Of Links MetaPath 134
Number of Shortest Paths 863272
Length Of Smallest Path 3
Average Path Length 34.6562
Length of Longest Path 77
Minimum Path Strength 1.305
Average Path Strength 5.85057
Maximum Path Strength 21.26
Minimum Path Correlation 0.7
Average Path Correlation 0.978017
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 45.5496
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.379
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • molecular transducer activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine binding   • protein binding   • binding   • chemokine binding   • cytokine binding   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • cell chemotaxis   • cellular response to stimulus   • chemotaxis   • response to stimulus   • response to external stimulus   • cellular response to chemical stimulus   • taxis   • response to chemical   • cell migration   • cellular process   • cell motility   • locomotion   • regulation of biological process   • regulation of cellular process   • signaling   • intracellular signal transduction   • cell communication   • calcium-mediated signaling   • intracellular signaling cassette   • signal transduction   • immune response   • immune system process   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to hormone   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8K4P_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ76SF8
Sequence
>8K4P_Chain_R
YTWNVGILS LIFLINVLG NGLVTYIFC KHRSRAGAI DILLLGICL 
NSLCLSISL LAEVLMFLF PNIISTGLC RLEIFFYYL YVYLDIFSV 
VCVSLVRYL LVAYSTRSW PKKQSLGWV LTSAALLIA LVLSGDACR 
HRSRVVDPV SKQAMCYEN AGNMTADWR LHVRTVSVT AGFLLPLAL 
LILFYALTW CVVRRTKLQ ARRKVRGVI VAVVLLFFV FCFPYHVLN 
LLDTLLRRR WIRDSCYTR GLINVGLAV TSLLQALYS AVVPLIYSC 
LGSLFRQRM YGLFQSLRQ SFMSGA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8K4P_Chain_A
GCTLSAEDK AAVERSKMI DRNLREDGE KAAREVKLL LLGAGESGK 
STIVKQMKI IHEKTTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI 
HCFEGVTAI IFCVALSDY DLVLAEDEE MNRMHESMK LFDSICNNK 
WFTDTSIIL FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY 
IQCQFEDLN KRKDTKEIY THFTCATDT KNVQFVFDA VTDVIIKNN 
LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8K4P_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8K4PAOtherUnclassifiedKSHVHuman gammaherpesvirus 8--Gi1/β1/γ12.812024-07-24To be published
8K4P (No Gprot) AOtherUnclassifiedKSHVHuman gammaherpesvirus 8--2.812024-07-24To be published
8K4OAOtherUnclassifiedKSHVHuman gammaherpesvirus 8CXCL1-Gi1/β1/γ13.012024-07-24To be published
8K4O (No Gprot) AOtherUnclassifiedKSHVHuman gammaherpesvirus 8CXCL1-3.012024-07-24To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8K4P.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.