Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F11 6.1725409
2R:R:L26 3.34486
3R:R:F30 5.3406
4R:R:Y34 8.645408
5R:R:N41 4.508509
6R:R:L54 6.6875409
7R:R:Y59 6.08167609
8R:R:D69 5.69469
9R:R:Y72 4.872565
10R:R:I91 3.6425109
11R:R:Q99 3.24109
12R:R:F101 6.8425113
13R:R:H104 5.452564
14R:R:E110 3.86668
15R:R:M111 5.6465
16R:R:Y131 5.181676149
17R:R:V144 4.88254155
18R:R:W148 4.02605
19R:R:F152 5.814113
20R:R:H154 5.5275464
21R:R:Q158 6.98564
22R:R:F167 3.285696
23R:R:F176 5.351676136
24R:R:F177 5.25754135
25R:R:D179 6.22468
26R:R:L180 4.486565
27R:R:N201 8.1075463
28R:R:S202 4.834563
29R:R:Y217 5.40754169
30R:R:H242 4.695169
31R:R:F249 5.905466
32R:R:F250 5.782566
33R:R:Y257 6.39833667
34R:R:F261 3.0375404
35R:R:F264 4.58254173
36R:R:Y274 3.59567
37R:R:N282 5.2175469
38A:A:Y37 8.464514
39A:A:H41 4.8025456
40A:A:R42 10.2175419
41A:A:L43 3.88557
42A:A:L44 8.646519
43A:A:L45 5.44833658
44A:A:V57 5.6125457
45A:A:V217 4.475455
46A:A:F219 6.26833658
47A:A:M221 4.64558
48A:A:F222 11.182517
49A:A:V224 5.594519
50A:A:Q227 7.39167619
51A:A:K233 7.02833619
52A:A:W234 7.76833619
53A:A:C237 5.374518
54A:A:F238 8.56429719
55A:A:D240 5.372516
56A:A:T242 3.7125458
57A:A:I245 4.348557
58A:A:F246 5.3275419
59A:A:S250 4.4725476
60A:A:D252 4.0954198
61A:A:Y253 8.2125408
62A:A:R265 7.2485199
63A:A:F273 5.82667619
64A:A:I276 4.1525418
65A:A:W277 10.644516
66A:A:W281 13.536515
67A:A:L282 4.488519
68A:A:I288 5.968509
69A:A:L289 7.1575409
70A:A:F290 6.17659
71A:A:L291 4.522578
72A:A:N292 5.745409
73A:A:K293 7.4785209
74A:A:Q294 6.488576
75A:A:L296 7.0154206
76A:A:L297 4.104578
77A:A:I308 8.07477
78A:A:F312 5.87578
79A:A:E314 2.8025476
80A:A:F315 13.244576
81A:A:Y318 7.9576
82A:A:P321 4.788575
83A:A:F340 12.048577
84A:A:I341 3.6275478
85A:A:R342 6.70667674
86A:A:E344 8.5225475
87A:A:F345 9.895408
88A:A:Y360 8.6045218
89A:A:F363 12.39475
90A:A:T364 7.224559
91A:A:D368 4.565459
92A:A:N371 6.334559
93A:A:R373 6.795455
94A:A:R374 9.095654
95A:A:F376 5.79857758
96A:A:R385 5.5275405
97B:B:I18 4.49537
98B:B:R22 6.358536
99B:B:L30 4.628525
100B:B:T34 5.96425
101B:B:I37 4.424522
102B:B:V40 5.00857723
103B:B:M45 4.302524
104B:B:L51 7.83649
105B:B:H54 11.33549
106B:B:K57 12.774519
107B:B:Y59 11.794518
108B:B:M61 3.09406
109B:B:W63 8.132547
110B:B:L69 5.555445
111B:B:L70 6.194545
112B:B:V71 5.044548
113B:B:S72 6.965449
114B:B:Q75 13.4419
115B:B:D76 7.214519
116B:B:K78 7.72408
117B:B:L79 5.066547
118B:B:I80 11.2525448
119B:B:I81 4.394547
120B:B:W82 10.5357749
121B:B:D83 9.036548
122B:B:S84 5.72445
123B:B:T86 8.6225446
124B:B:K89 6.54143749
125B:B:H91 6.07445
126B:B:I93 5.13547
127B:B:L95 5.11548
128B:B:W99 10.5083619
129B:B:M101 5.5175419
130B:B:Y105 5.27746
131B:B:C114 4.496548
132B:B:L117 5.18333619
133B:B:N119 3.6775419
134B:B:C121 4.135418
135B:B:I123 3.876516
136B:B:Y124 5.81646
137B:B:L126 4.972545
138B:B:V133 6.1444
139B:B:E138 7.97406
140B:B:L139 5.93509
141B:B:H142 6.95833619
142B:B:Y145 7.52857718
143B:B:L146 4.39617
144B:B:F151 5.45619
145B:B:L152 4.48533
146B:B:I157 6.3175417
147B:B:V158 3.73535
148B:B:T159 5.19833619
149B:B:S160 5.2436
150B:B:S161 5.92419
151B:B:D163 7.11419
152B:B:C166 4.016538
153B:B:L168 4.51333636
154B:B:W169 8.31286718
155B:B:F180 8.374537
156B:B:H183 8.63639
157B:B:D186 6.9925419
158B:B:V187 5.578539
159B:B:L190 5.24435
160B:B:L192 4.0975435
161B:B:F199 7.804539
162B:B:V200 7.57436
163B:B:S201 5.305439
164B:B:C204 5.566517
165B:B:D205 5.46539
166B:B:K209 8.48833636
167B:B:L210 6.822535
168B:B:W211 8.43167638
169B:B:D212 7.975409
170B:B:Q220 6.688537
171B:B:F222 7.51333638
172B:B:H225 8.09839
173B:B:D228 9.25519
174B:B:I229 5.4437
175B:B:I232 5.09438
176B:B:F234 4.956535
177B:B:F235 5.42826
178B:B:P236 5.2925427
179B:B:N237 8.79425
180B:B:F241 8.42536
181B:B:T243 5.61438
182B:B:D246 7.215419
183B:B:D247 7.594539
184B:B:T249 6.29536
185B:B:R251 8.43286738
186B:B:F253 6.29333636
187B:B:D254 4.92629
188B:B:R256 9.04409
189B:B:D258 8.43537
190B:B:M262 6.9325424
191B:B:Y264 7.33625
192B:B:I269 4.1775424
193B:B:S277 4.015425
194B:B:F278 5.45667627
195B:B:R283 8.09167629
196B:B:L284 5.0725425
197B:B:L286 4.402527
198B:B:Y289 7.93571727
199B:B:D290 8.6425416
200B:B:C294 3.8975425
201B:B:N295 7.078526
202B:B:V296 4.5725425
203B:B:W297 9.235428
204B:B:L300 5.79833626
205B:B:K301 4.575405
206B:B:R304 9.505425
207B:B:H311 10.194529
208B:B:R314 17.162518
209B:B:V315 4.045427
210B:B:L318 4.168526
211B:B:T329 6.7625428
212B:B:W332 12.1029719
213B:B:D333 7.716529
214B:B:L336 6.922547
215B:B:K337 11.6375426
216B:B:I338 5.7625445
217B:B:W339 10.638529
218G:G:Q18 6.625439
219G:G:L19 3.8325409
220G:G:E22 5.3439
221G:G:R27 7.772538
222G:G:L37 3.552527
223G:G:M38 4.02524
224G:G:Y40 10.225426
225G:G:D48 7.205409
226G:G:L50 4.7775429
227G:G:L51 3.8526
228G:G:N59 4.9775449
229G:G:P60 7.535449
230G:G:F61 5.714548
231L:L:?1 6.645860
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F167 R:R:F93 17.18543.22YesNo964
2R:R:F167 R:R:L165 14.57843.65YesNo967
3R:R:L165 R:R:P166 12.1491.64NoNo075
4R:R:F93 R:R:M97 21.00126.22NoNo045
5R:R:I162 R:R:M97 28.62914.37NoNo055
6R:R:I162 R:R:L180 30.5367.14NoYes655
7R:R:L180 R:R:Q158 15.61955.32YesYes654
8R:R:H104 R:R:Q158 14.58146.18YesYes644
9R:R:F249 R:R:Y72 46.66563.09YesYes665
10R:R:E110 R:R:F249 76.5424.66YesYes686
11R:R:D69 R:R:N41 11.73224.04YesYes099
12R:R:D179 R:R:L180 18.7382.71YesYes685
13L:L:?1 R:R:H104 17.00019.37YesYes604
14L:L:?1 R:R:Y72 26.2788.54YesYes605
15L:L:?1 R:R:S202 12.8274.38YesYes603
16L:L:?1 R:R:Y257 18.028113.67YesYes607
17R:R:I173 R:R:P182 15.65073.39NoNo077
18R:R:P181 R:R:P182 16.1725.84NoNo047
19R:R:P181 R:R:Y257 16.65714.17NoYes647
20R:R:Y274 R:R:Y72 11.42033.97YesYes675
21L:L:?1 R:R:M111 26.41194.12YesYes605
22R:R:F249 R:R:M111 27.65046.22YesYes665
23R:R:E110 R:R:N282 13.66063.94YesYes689
24R:R:E110 R:R:L65 76.24633.98YesNo689
25R:R:L65 R:R:M117 91.28342.83NoNo099
26R:R:L62 R:R:M117 92.02292.83NoNo099
27R:R:L62 R:R:M58 92.12952.83NoNo099
28A:A:Y391 R:R:M58 94.134.79NoNo049
29A:A:Y391 R:R:Y131 94.36163.97NoYes049
30R:R:N282 R:R:Y286 18.90295.81YesNo099
31R:R:H242 R:R:Y286 18.60676.53YesNo099
32R:R:H242 R:R:Y217 15.6174.36YesYes1699
33R:R:A235 R:R:L224 13.48961.58NoNo095
34R:R:A235 R:R:L221 13.68781.58NoNo095
35R:R:C239 R:R:L221 14.62073.17NoNo095
36R:R:C239 R:R:Y217 14.87154.03NoYes099
37A:A:F219 A:A:L43 23.94193.65YesYes587
38A:A:I245 A:A:L43 12.72175.71YesYes577
39A:A:D378 A:A:Y360 15.554913.79NoYes078
40A:A:Y358 A:A:Y360 10.57682.98NoYes048
41A:A:L394 A:A:R385 14.62642.43NoYes085
42A:A:L388 A:A:L394 12.78285.54NoNo088
43A:A:L388 A:A:Q384 11.95642.66NoNo086
44A:A:Q384 R:R:H227 11.56772.47NoNo064
45R:R:H227 R:R:L224 11.93723.86NoNo045
46A:A:D381 A:A:Y360 10.576811.49NoYes088
47R:R:L132 R:R:Y131 98.79143.52NoYes049
48A:A:R38 R:R:L132 98.98168.5NoNo044
49B:B:I338 G:G:F61 10.53535.02YesYes458
50A:A:K34 B:B:L55 1005.64NoNo046
51A:A:K34 A:A:R38 99.79352.48NoNo044
52B:B:D76 B:B:K78 12.61948.3YesYes098
53A:A:R42 A:A:Y37 22.868226.75YesYes194
54A:A:Y37 B:B:L55 93.56533.52YesNo146
55A:A:D240 A:A:Y37 82.34984.6YesYes164
56A:A:F222 A:A:R42 23.12564.28YesYes179
57A:A:F290 A:A:I375 10.11965.02YesNo599
58A:A:F290 A:A:I288 10.04723.77YesYes099
59A:A:F238 A:A:L44 23.698721.92YesYes199
60A:A:F222 A:A:F238 23.21653.22YesYes179
61A:A:F238 B:B:W99 23.013716.04YesYes199
62A:A:D240 B:B:W99 51.40446.7YesYes169
63A:A:L44 A:A:L46 22.75076.92YesNo198
64A:A:I245 A:A:L45 10.81644.28YesYes578
65A:A:L45 A:A:V247 22.73812.98YesNo587
66A:A:I276 A:A:L46 22.71412.85YesNo188
67A:A:D249 A:A:D252 57.56992.66NoYes088
68A:A:D249 A:A:K293 57.398813.83NoYes089
69A:A:K293 A:A:N292 55.49894.2YesYes099
70A:A:N292 A:A:T364 30.64345.85YesYes099
71A:A:F290 A:A:T364 24.50156.49YesYes599
72B:B:L117 B:B:W99 28.51355.69YesYes199
73A:A:Q227 B:B:L117 11.67.99YesYes199
74A:A:F238 A:A:W234 45.59074.01YesYes199
75A:A:W234 B:B:L117 28.38386.83YesYes199
76A:A:Q227 B:B:Y145 11.54419.02YesYes198
77A:A:W234 B:B:Y145 57.88736.75YesYes198
78B:B:M101 B:B:Y145 29.30148.38YesYes198
79B:B:M101 B:B:Y59 29.27273.59YesYes198
80B:B:K57 B:B:Y59 11.48714.33YesYes198
81A:A:D240 B:B:K57 21.70296.91YesYes169
82A:A:R228 B:B:D186 44.58038.34NoYes099
83B:B:D186 B:B:Y145 45.031711.49YesYes198
84A:A:R228 B:B:T164 44.04285.17NoNo096
85A:A:R231 A:A:W234 63.66588NoYes099
86A:A:L272 A:A:R231 63.53068.5NoNo089
87A:A:N239 B:B:W332 10.22046.78NoYes189
88A:A:D240 A:A:N239 10.29542.69YesNo168
89B:B:R314 B:B:W332 59.507823.99YesYes189
90B:B:K57 B:B:W332 10.310815.08YesYes199
91A:A:C237 A:A:F238 23.06635.59YesYes189
92A:A:C237 B:B:L117 11.5574.76YesYes189
93A:A:C237 B:B:Y59 34.33084.03YesYes188
94A:A:F246 A:A:L272 63.35217.31YesNo198
95A:A:F246 A:A:I276 22.91173.77YesYes198
96A:A:F246 A:A:L289 80.73434.87YesYes099
97A:A:L289 A:A:L291 74.62398.3YesYes098
98A:A:L291 A:A:S250 23.73413YesYes786
99A:A:L291 A:A:Q294 24.9573.99YesYes786
100A:A:L297 A:A:S250 23.50526.01YesYes786
101A:A:L297 A:A:Q294 23.69043.99YesYes786
102A:A:I341 A:A:L297 23.52562.85YesYes788
103A:A:I341 A:A:L291 25.89732.85YesYes788
104A:A:D252 A:A:N264 59.00882.69YesNo089
105A:A:L297 A:A:Y253 63.71294.69YesYes088
106A:A:Y253 A:A:Y311 61.27168.94YesNo086
107B:B:T221 G:G:E22 37.3549.88NoYes079
108B:B:K209 B:B:T221 37.751610.51YesNo067
109B:B:H183 B:B:K209 19.716214.41YesYes396
110B:B:D205 B:B:H183 22.43056.3YesYes399
111B:B:D205 B:B:G185 43.65793.35YesNo095
112B:B:G185 B:B:T164 43.85023.64NoNo056
113B:B:K209 B:B:S207 19.71854.59YesNo065
114B:B:D205 B:B:S207 20.27815.89YesNo095
115B:B:R22 G:G:E22 30.57543.49YesYes369
116B:B:D258 B:B:R22 27.73628.34YesYes376
117B:B:R283 B:B:V40 28.82517.85YesYes293
118B:B:I43 B:B:V40 16.40893.07NoYes233
119B:B:I43 B:B:M45 16.60252.92NoYes234
120B:B:L286 B:B:M45 17.64012.83YesYes274
121B:B:L286 B:B:L318 56.74712.77YesYes276
122B:B:L318 B:B:S275 58.50824.5YesNo068
123B:B:S275 B:B:T274 58.68754.8NoNo088
124B:B:R314 B:B:T274 58.8017.76YesNo188
125B:B:L300 B:B:R283 14.03269.72YesYes269
126B:B:L284 B:B:V40 16.30644.47YesYes253
127B:B:L284 B:B:V296 31.82985.96YesYes255
128B:B:L286 B:B:V296 37.80087.45YesYes275
129B:B:R283 G:G:L51 14.39214.86YesYes296
130B:B:L284 G:G:L51 15.33534.15YesYes256
131B:B:C317 B:B:M61 10.58853.24NoYes076
132B:B:C317 B:B:S316 10.74433.44NoNo079
133B:B:S316 B:B:W332 10.93366.18NoYes099
134B:B:C148 B:B:T102 10.83343.38NoNo068
135B:B:L146 B:B:T102 10.87714.42YesNo078
136B:B:L146 B:B:S161 18.89053YesYes179
137B:B:G162 B:B:S161 28.24433.71NoYes199
138B:B:G162 B:B:Y145 28.35238.69NoYes198
139B:B:D258 B:B:F222 19.90874.78YesYes378
140B:B:F235 G:G:C41 21.04822.79YesNo267
141B:B:R283 G:G:C41 21.61995.57YesNo297
142R:R:D69 R:R:L65 14.94156.79YesNo699
143A:A:N264 A:A:Y311 59.189610.47NoNo096
144A:A:N292 A:A:V247 24.02844.43YesNo097
145A:A:L45 A:A:M221 10.27178.48YesYes588
146A:A:Y37 B:B:D76 11.25173.45YesYes149
147B:B:W332 B:B:Y59 52.130414.47YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L103 R:R:Y72 5.86 6 No Yes 4 5 1 1
R:R:G107 R:R:Y72 2.9 0 No Yes 5 5 2 1
R:R:F249 R:R:Y72 3.09 6 Yes Yes 6 5 2 1
R:R:Y274 R:R:Y72 3.97 6 Yes Yes 7 5 1 1
L:L:?1 R:R:Y72 8.54 6 Yes Yes 0 5 0 1
R:R:H104 R:R:L103 5.14 6 Yes No 4 4 1 1
L:L:?1 R:R:L103 4.04 6 Yes No 0 4 0 1
R:R:H104 R:R:S155 2.79 6 Yes No 4 5 1 2
R:R:H104 R:R:Q158 6.18 6 Yes Yes 4 4 1 2
R:R:D179 R:R:H104 3.78 6 Yes Yes 8 4 2 1
L:L:?1 R:R:H104 9.37 6 Yes Yes 0 4 0 1
R:R:G108 R:R:H154 4.77 0 No Yes 3 4 2 1
R:R:M111 R:R:S206 4.6 6 Yes No 5 3 1 2
R:R:F249 R:R:M111 6.22 6 Yes Yes 6 5 2 1
R:R:F250 R:R:M111 7.46 6 Yes Yes 6 5 2 1
L:L:?1 R:R:M111 4.12 6 Yes Yes 0 5 0 1
R:R:H154 R:R:N201 8.93 6 Yes Yes 4 3 1 2
R:R:H154 R:R:S202 2.79 6 Yes Yes 4 3 1 1
L:L:?1 R:R:H154 5.62 6 Yes Yes 0 4 0 1
R:R:N201 R:R:Q158 11.88 6 Yes Yes 3 4 2 2
R:R:Q158 R:R:S202 7.22 6 Yes Yes 4 3 2 1
R:R:D179 R:R:P181 8.05 6 Yes No 8 4 2 2
R:R:D179 R:R:Y257 10.34 6 Yes Yes 8 7 2 1
R:R:P181 R:R:Y257 4.17 6 No Yes 4 7 2 1
R:R:N201 R:R:S202 5.96 6 Yes Yes 3 3 2 1
R:R:S202 R:R:Y257 3.82 6 Yes Yes 3 7 1 1
L:L:?1 R:R:S202 4.38 6 Yes Yes 0 3 0 1
R:R:F249 R:R:F250 9.65 6 Yes Yes 6 6 2 2
R:R:P252 R:R:Y274 4.17 0 No Yes 7 7 2 1
R:R:Y257 R:R:Y274 3.97 6 Yes Yes 7 7 1 1
L:L:?1 R:R:Y257 13.67 6 Yes Yes 0 7 0 1
L:L:?1 R:R:Y274 3.42 6 Yes Yes 0 7 0 1
R:R:I256 R:R:Y257 2.42 6 No Yes 5 7 2 1
R:R:I256 R:R:Y274 2.42 6 No Yes 5 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription

PDB Summary
PDB 8UYQ
Class O2
SubFamily Odorant receptors
Type Odorant family 4
SubType consOR4
Species Homo Sapiens
Ligand 2-methylthiazoline
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.5
Date 2024-10-30 
D.O.I. doi.org/10.1038/s41586-024-08126-0
Net Summary
Imin 2.69
Number of Linked Nodes 867
Number of Links 1168
Number of Hubs 231
Number of Links mediated by Hubs 791
Number of Communities 24
Number of Nodes involved in Communities 345
Number of Links involved in Communities 574
Path Summary
Number Of Nodes in MetaPath 148
Number Of Links MetaPath 147
Number of Shortest Paths 4854251
Length Of Smallest Path 3
Average Path Length 30.7482
Length of Longest Path 48
Minimum Path Strength 1.295
Average Path Strength 6.04236
Maximum Path Strength 22.905
Minimum Path Correlation 0.7
Average Path Correlation 0.993065
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 40.5692
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 57.7273
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeXVT
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeXVT
Name(2R)-2-methyl-1,3-thiazolidine
Synonyms
Identifier
FormulaC4 H9 N S
Molecular Weight103.186
SMILES
PubChem6999028
Formal Charge0
Total Atoms15
Total Chiral Atoms1
Total Bonds15
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtCons
Sequence
>8UYQ_Chain_R
FPLTPHSNV TEFILLGLT QSPEQLFLF VVFLLFYVA TVGNLLIVV 
TVTSDPHLH SPMYFLANL SFIDICYSS VTAPKMIVD LLSERKTIS 
FNGCMTQIL HFFGGAEMF LLVVMAYDR YVAICKPLH YLTIMNRRV 
CVLLVAVAW VGGFLHSII QLAFIVQLF CGPNVIDSF FCDPPVLKL 
ACTDTYVLG LLVIANGIS CFLLLLISY VILVSLRSH SEGRKALTC 
SHTVVILFF GPCIFIYRP FTTFPMDKV AFYTVITLN PIYTLRNKE 
KAAMRKLWS RKVISSRKL LLFSLLLVS SSITFVLLM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8UYQ_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAS GKSTIVKQM 
RGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND VTAIIFVVS 
SYNRLQEAL NLFKSIWNN RWLRTISVI LFLNKQDLL AEKVLASKI 
EDYFPEFAR YTTPPGEDP RVTRAKYFI RDEFLRIST ASRHYCYPH 
FTCAVDTEN RRFNDCRDI IQRMHLRQY ELLDNDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8UYQ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8UYQ_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UYQO2Odorant receptorsOdorant family 4consOR4Homo sapiens2-methylthiazoline-Gs/β1/γ23.52024-10-30doi.org/10.1038/s41586-024-08126-0
8UYQ (No Gprot) O2Odorant receptorsOdorant family 4consOR4Homo sapiens2-methylthiazoline-3.52024-10-30doi.org/10.1038/s41586-024-08126-0




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