psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H5	R:R:P166	9.15	No	No	0	9	5
2	R:R:C168	R:R:H5	4.42	No	No	5	8	9
3	R:R:C188	R:R:H5	5.9	No	No	5	9	9
4	R:R:F93	R:R:N7	16.92	No	No	3	4	4
5	R:R:F167	R:R:N7	3.62	Yes	No	3	6	4
6	R:R:F11	R:R:V8	7.87	Yes	No	0	9	6
7	R:R:F167	R:R:V8	2.62	Yes	No	0	6	6
8	R:R:N171	R:R:V8	2.96	No	No	0	6	6
9	R:R:E10	R:R:T90	16.93	No	No	0	5	4
10	R:R:C96	R:R:F11	5.59	No	Yes	0	9	9
11	R:R:F11	R:R:I173	8.79	Yes	No	0	9	7
12	R:R:I12	R:R:N171	5.66	No	No	0	6	6
13	R:R:D83	R:R:L13	2.71	No	No	0	6	8
14	R:R:I91	R:R:L13	2.85	Yes	No	0	9	8
15	R:R:I173	R:R:L13	2.85	No	No	0	7	8
16	R:R:L14	R:R:V172	4.47	No	No	0	4	3
17	R:R:D174	R:R:L14	5.43	No	No	0	5	4
18	R:R:F176	R:R:L16	6.09	Yes	No	0	6	6
19	R:R:L22	R:R:T17	11.79	No	No	2	6	7
20	R:R:L26	R:R:T17	2.95	Yes	No	2	6	7
21	R:R:P20	R:R:S19	3.56	No	No	2	4	2
22	R:R:E21	R:R:S19	7.19	No	No	2	2	2
23	R:R:L22	R:R:S19	3	No	No	2	6	2
24	R:R:E21	R:R:P20	4.72	No	No	2	2	4
25	R:R:L22	R:R:L26	2.77	No	Yes	2	6	6
26	R:R:L84	R:R:Q23	2.66	No	No	0	4	6
27	R:R:K89	R:R:Q23	4.07	No	No	0	5	6
28	R:R:F25	R:R:V29	5.24	No	No	0	3	4
29	R:R:F30	R:R:L26	4.87	Yes	Yes	0	6	6
30	R:R:L26	R:R:L84	2.77	Yes	No	0	6	4
31	R:R:F27	R:R:I81	3.77	No	No	0	7	8
32	R:R:F27	R:R:L85	15.83	No	No	0	7	5
33	R:R:L32	R:R:V28	2.98	No	No	0	1	3
34	R:R:F33	R:R:V29	6.55	No	No	0	5	4
35	R:R:F30	R:R:M80	11.2	Yes	No	0	6	6
36	R:R:F30	R:R:V276	2.62	Yes	No	0	6	5
37	R:R:I81	R:R:L31	2.85	No	No	0	8	5
38	R:R:F33	R:R:V276	2.62	No	No	0	5	5
39	R:R:V38	R:R:Y34	6.31	No	Yes	0	4	8
40	R:R:S74	R:R:Y34	7.63	No	Yes	0	7	8
41	R:R:A77	R:R:Y34	5.34	No	Yes	0	5	8
42	R:R:P78	R:R:Y34	15.3	No	Yes	0	9	8
43	R:R:L39	R:R:V35	2.98	No	No	0	5	4
44	R:R:N41	R:R:T37	2.92	Yes	No	0	9	7
45	R:R:S73	R:R:T37	3.2	No	No	0	7	7
46	R:R:L280	R:R:T37	2.95	No	No	0	6	7
47	R:R:N41	R:R:S66	2.98	Yes	No	0	9	9
48	R:R:D69	R:R:N41	4.04	Yes	Yes	0	9	9
49	R:R:I70	R:R:N41	2.83	No	Yes	0	5	9
50	R:R:N41	R:R:P283	9.77	Yes	No	0	9	9
51	R:R:L43	R:R:M297	4.24	No	No	0	5	5
52	R:R:I44	R:R:S66	3.1	No	No	0	8	9
53	R:R:I44	R:R:T287	4.56	No	No	0	8	9
54	R:R:L300	R:R:T47	4.42	No	No	0	3	5
55	R:R:D51	R:R:P52	4.83	No	No	0	7	4
56	R:R:D51	R:R:L54	6.79	No	Yes	0	7	9
57	R:R:D51	R:R:K299	5.53	No	No	0	7	5
58	R:R:H53	R:R:L54	9	No	Yes	0	4	9
59	R:R:E292	R:R:H53	8.62	No	No	0	6	4
60	R:R:L54	R:R:Y59	9.38	Yes	Yes	0	9	9
61	R:R:P57	R:R:S56	3.56	No	No	0	9	7
62	R:R:S56	R:R:Y59	5.09	No	Yes	0	7	9
63	R:R:P57	R:R:Y131	5.56	No	Yes	0	9	9
64	R:R:C140	R:R:P57	3.77	No	No	0	7	9
65	R:R:M58	R:R:Y59	3.59	No	Yes	0	9	9
66	R:R:L62	R:R:M58	2.83	No	No	0	9	9
67	R:R:N290	R:R:Y59	5.81	No	Yes	0	9	9
68	R:R:E292	R:R:Y59	10.1	No	Yes	0	6	9
69	R:R:F60	R:R:N64	7.25	No	No	8	6	7
70	R:R:F60	R:R:V144	5.24	No	Yes	8	6	5
71	R:R:L61	R:R:V116	2.98	No	No	0	9	6
72	R:R:L61	R:R:M117	5.65	No	No	0	9	9
73	R:R:L62	R:R:M117	2.83	No	No	0	9	9
74	R:R:N64	R:R:V144	10.35	No	Yes	8	7	5
75	R:R:D69	R:R:L65	6.79	Yes	No	1	9	9
76	R:R:E110	R:R:L65	3.98	Yes	No	1	8	9
77	R:R:L65	R:R:M117	2.83	No	No	0	9	9
78	R:R:F67	R:R:W148	4.01	No	Yes	0	4	5
79	R:R:E110	R:R:I68	2.73	Yes	No	0	8	5
80	R:R:I68	R:R:W148	7.05	No	Yes	0	5	5
81	R:R:D69	R:R:E110	5.2	Yes	Yes	1	9	8
82	R:R:D69	R:R:N282	6.73	Yes	Yes	1	9	9
83	R:R:C71	R:R:F106	12.57	No	No	0	4	4
84	R:R:L103	R:R:Y72	5.86	No	Yes	1	4	5
85	R:R:G107	R:R:Y72	2.9	No	Yes	0	5	5
86	R:R:F249	R:R:Y72	3.09	Yes	Yes	1	6	5
87	R:R:Y274	R:R:Y72	3.97	Yes	Yes	1	7	5
88	L:L:?1	R:R:Y72	8.54	Yes	Yes	1	0	5
89	R:R:P279	R:R:S73	3.56	No	No	0	9	7
90	R:R:Q99	R:R:V75	4.3	Yes	No	0	9	6
91	R:R:F177	R:R:T76	3.89	Yes	No	0	5	7
92	R:R:T275	R:R:T76	7.85	No	No	0	6	7
93	R:R:D83	R:R:K79	16.59	No	No	0	6	7
94	R:R:I91	R:R:K79	5.82	Yes	No	4	9	7
95	R:R:K79	R:R:Q99	2.71	No	Yes	4	7	9
96	R:R:F176	R:R:M80	8.71	Yes	No	0	6	6
97	R:R:G95	R:R:I91	3.53	No	Yes	0	5	9
98	R:R:I91	R:R:Q99	2.74	Yes	Yes	4	9	9
99	R:R:C178	R:R:I91	3.27	No	Yes	4	9	9
100	R:R:F93	R:R:M97	6.22	No	No	0	4	5
101	R:R:F167	R:R:F93	3.22	Yes	No	3	6	4
102	R:R:C178	R:R:C96	5.46	No	No	0	9	9
103	R:R:I162	R:R:M97	4.37	No	No	0	5	5
104	R:R:M97	R:R:V163	4.56	No	No	0	5	4
105	R:R:C178	R:R:Q99	3.05	No	Yes	4	9	9
106	R:R:H104	R:R:I100	2.65	Yes	No	1	4	5
107	R:R:I100	R:R:I162	4.42	No	No	1	5	5
108	R:R:I100	R:R:L180	4.28	No	Yes	1	5	5
109	R:R:F101	R:R:F102	10.72	Yes	No	0	3	4
110	R:R:F101	R:R:F105	7.5	Yes	Yes	1	3	3
111	R:R:F101	R:R:F152	4.29	Yes	Yes	1	3	3
112	R:R:F101	R:R:S155	7.93	Yes	No	1	3	5
113	R:R:F101	R:R:I156	3.77	Yes	No	1	3	1
114	R:R:F102	R:R:F106	5.36	No	No	0	4	4
115	R:R:H104	R:R:L103	5.14	Yes	No	1	4	4
116	L:L:?1	R:R:L103	4.04	Yes	No	1	0	4
117	R:R:H104	R:R:S155	2.79	Yes	No	1	4	5
118	R:R:H104	R:R:Q158	6.18	Yes	Yes	1	4	4
119	R:R:D179	R:R:H104	3.78	Yes	Yes	1	8	4
120	L:L:?1	R:R:H104	9.37	Yes	Yes	1	0	4
121	R:R:F105	R:R:W148	4.01	Yes	Yes	0	3	5
122	R:R:F105	R:R:F152	6.43	Yes	Yes	1	3	3
123	R:R:F105	R:R:S155	2.64	Yes	No	1	3	5
124	R:R:F106	R:R:W148	4.01	No	Yes	0	4	5
125	R:R:G108	R:R:H154	4.77	No	Yes	0	3	4
126	R:R:E110	R:R:L114	2.65	Yes	No	0	8	9
127	R:R:E110	R:R:F249	4.66	Yes	Yes	1	8	6
128	R:R:E110	R:R:N282	3.94	Yes	Yes	1	8	9
129	R:R:M111	R:R:S206	4.6	Yes	No	0	5	3
130	R:R:F249	R:R:M111	6.22	Yes	Yes	1	6	5
131	R:R:F250	R:R:M111	7.46	Yes	Yes	1	6	5
132	L:L:?1	R:R:M111	4.12	Yes	Yes	1	0	5
133	R:R:F112	R:R:G150	3.01	No	No	0	3	3
134	R:R:F112	R:R:G151	3.01	No	No	0	3	7
135	R:R:C209	R:R:V115	3.42	No	No	0	6	6
136	R:R:L212	R:R:V115	2.98	No	No	0	4	6
137	R:R:L143	R:R:V116	4.47	No	No	0	7	6
138	R:R:A118	R:R:S216	3.42	No	No	0	9	9
139	R:R:V123	R:R:Y119	7.57	No	No	0	7	5
140	R:R:D120	R:R:Y131	8.05	No	Yes	7	9	9
141	R:R:D120	R:R:M135	4.16	No	No	7	9	8
142	R:R:R121	R:R:Y217	7.2	No	Yes	9	9	9
143	R:R:H242	R:R:R121	5.64	Yes	No	9	9	9
144	R:R:C126	R:R:Y122	8.06	No	No	0	8	7
145	R:R:I134	R:R:V123	6.14	No	No	0	6	7
146	R:R:A124	R:R:Y131	4	No	Yes	0	9	9
147	R:R:I125	R:R:I220	4.42	No	No	0	9	9
148	R:R:C126	R:R:S223	3.44	No	No	0	8	6
149	R:R:H130	R:R:K127	2.62	No	No	0	7	4
150	R:R:L132	R:R:Y131	3.52	No	Yes	0	4	9
151	R:R:M135	R:R:Y131	5.99	No	Yes	7	8	9
152	R:R:I134	R:R:M135	2.92	No	No	0	6	8
153	R:R:L143	R:R:V139	2.98	No	No	0	7	4
154	R:R:L142	R:R:V146	2.98	No	No	0	1	3
155	R:R:F152	R:R:I156	11.3	Yes	No	1	3	1
156	R:R:H154	R:R:N201	8.93	Yes	Yes	1	4	3
157	R:R:H154	R:R:S202	2.79	Yes	Yes	1	4	3
158	L:L:?1	R:R:H154	5.62	Yes	Yes	1	0	4
159	R:R:I157	R:R:L197	4.28	No	No	0	4	4
160	R:R:I157	R:R:N201	5.66	No	Yes	0	4	3
161	R:R:L180	R:R:Q158	5.32	Yes	Yes	1	5	4
162	R:R:Q158	R:R:V198	4.3	Yes	No	1	4	4
163	R:R:N201	R:R:Q158	11.88	Yes	Yes	1	3	4
164	R:R:Q158	R:R:S202	7.22	Yes	Yes	1	4	3
165	R:R:L159	R:R:V163	2.98	No	No	0	6	4
166	R:R:A160	R:R:F161	2.77	No	No	0	2	4
167	R:R:F161	R:R:L194	4.87	No	No	0	4	5
168	R:R:I162	R:R:L180	7.14	No	Yes	1	5	5
169	R:R:F167	R:R:L165	3.65	Yes	No	3	6	7
170	R:R:A187	R:R:L165	6.3	No	No	3	8	7
171	R:R:P166	R:R:T189	8.74	No	No	0	5	6
172	R:R:F167	R:R:V183	2.62	Yes	No	0	6	6
173	R:R:A187	R:R:F167	4.16	No	Yes	3	8	6
174	R:R:C168	R:R:C188	3.64	No	No	5	8	9
175	R:R:G169	R:R:P170	4.06	No	No	0	4	5
176	R:R:I173	R:R:P182	3.39	No	No	0	7	7
177	R:R:D174	R:R:K268	11.06	No	No	0	5	6
178	R:R:F177	R:R:S175	3.96	Yes	No	0	5	8
179	R:R:F176	R:R:F177	11.79	Yes	Yes	6	6	5
180	R:R:F176	R:R:V272	2.62	Yes	No	0	6	5
181	R:R:D179	R:R:L180	2.71	Yes	Yes	1	8	5
182	R:R:D179	R:R:P181	8.05	Yes	No	1	8	4
183	R:R:D179	R:R:Y257	10.34	Yes	Yes	1	8	7
184	R:R:L180	R:R:V198	2.98	Yes	No	1	5	4
185	R:R:P181	R:R:P182	5.84	No	No	0	4	7
186	R:R:P181	R:R:Y257	4.17	No	Yes	1	4	7
187	R:R:L184	R:R:T191	4.42	No	No	0	5	7
188	R:R:L184	R:R:L194	2.77	No	No	0	5	5
189	R:R:D190	R:R:Y192	3.45	No	No	0	7	3
190	R:R:L196	R:R:Y192	11.72	No	No	0	2	3
191	R:R:L194	R:R:L197	2.77	No	No	0	5	4
192	R:R:F261	R:R:G195	3.01	Yes	No	0	4	5
193	R:R:I199	R:R:P260	6.77	No	No	0	3	7
194	R:R:N201	R:R:S202	5.96	Yes	Yes	1	3	3
195	R:R:S202	R:R:Y257	3.82	Yes	Yes	1	3	7
196	L:L:?1	R:R:S202	4.38	Yes	Yes	1	0	3
197	R:R:C253	R:R:S206	3.44	No	No	0	3	3
198	R:R:L208	R:R:L212	4.15	No	No	0	4	4
199	R:R:C209	R:R:F250	2.79	No	Yes	0	6	6
200	R:R:F210	R:R:V246	2.62	No	No	1	5	8
201	R:R:F210	R:R:F250	5.36	No	Yes	1	5	6
202	R:R:L213	R:R:V246	2.98	No	No	1	8	8
203	R:R:F250	R:R:L213	3.65	Yes	No	1	6	8
204	R:R:C239	R:R:Y217	4.03	No	Yes	0	9	9
205	R:R:H242	R:R:Y217	4.36	Yes	Yes	9	9	9
206	R:R:I243	R:R:Y217	6.04	No	Yes	0	5	9
207	R:R:I220	R:R:L224	2.85	No	No	0	9	5
208	R:R:C239	R:R:L221	3.17	No	No	0	9	5
209	R:R:R225	R:R:V222	2.62	No	No	0	5	1
210	R:R:H227	R:R:L224	3.86	No	No	0	4	5
211	R:R:K234	R:R:T238	3	No	No	0	9	9
212	R:R:H242	R:R:T238	2.74	Yes	No	0	9	9
213	R:R:H242	R:R:S241	4.18	Yes	No	0	9	9
214	R:R:H242	R:R:Y286	6.53	Yes	No	0	9	9
215	R:R:I285	R:R:V245	6.14	No	No	0	9	7
216	R:R:F250	R:R:V246	2.62	Yes	No	1	6	8
217	R:R:F249	R:R:F250	9.65	Yes	Yes	1	6	6
218	R:R:G251	R:R:P252	4.06	No	No	0	5	7
219	R:R:P252	R:R:V270	3.53	No	No	0	7	4
220	R:R:P252	R:R:Y274	4.17	No	Yes	0	7	7
221	R:R:F255	R:R:R259	4.28	No	No	0	4	5
222	R:R:F255	R:R:V270	2.62	No	No	0	4	4
223	R:R:Y257	R:R:Y274	3.97	Yes	Yes	1	7	7
224	L:L:?1	R:R:Y257	13.67	Yes	Yes	1	0	7
225	R:R:F264	R:R:R259	9.62	Yes	No	10	3	5
226	R:R:D267	R:R:R259	10.72	No	No	10	6	5
227	R:R:F261	R:R:P260	5.78	Yes	No	0	4	7
228	R:R:D267	R:R:T263	2.89	No	No	0	6	5
229	R:R:D267	R:R:F264	5.97	No	Yes	10	6	3
230	R:R:F269	R:R:M266	11.2	No	No	0	5	3
231	R:R:I277	R:R:V272	3.07	No	No	0	6	5
232	L:L:?1	R:R:Y274	3.42	Yes	Yes	1	0	7
233	R:R:I277	R:R:L281	2.85	No	No	0	6	6
234	R:R:P279	R:R:T278	3.5	No	No	0	9	8
235	R:R:N282	R:R:T278	4.39	Yes	No	0	9	8
236	R:R:N282	R:R:Y286	5.81	Yes	No	0	9	9
237	R:R:M293	R:R:T287	4.52	No	No	0	5	9
238	R:R:K294	R:R:L288	2.82	No	No	0	7	8
239	R:R:M293	R:R:M297	4.33	No	No	0	5	5
240	R:R:K299	R:R:R303	13.61	No	No	0	5	5
241	R:R:I306	R:R:V305	3.07	No	No	0	3	1
242	R:R:I306	R:R:R309	6.26	No	No	0	3	7
243	R:R:F102	R:R:T98	2.59	No	No	0	4	4
244	R:R:A109	R:R:W148	2.59	No	Yes	0	5	5
245	R:R:V48	R:R:Y59	2.52	No	Yes	0	7	9
246	R:R:V219	R:R:Y122	2.52	No	No	0	3	7
247	R:R:F30	R:R:I81	2.51	Yes	No	0	6	8
248	R:R:F210	R:R:I247	2.51	No	No	0	5	5
249	R:R:V144	R:R:W148	2.45	Yes	Yes	0	5	5
250	R:R:F11	R:R:L186	2.44	Yes	No	0	9	7
251	R:R:F33	R:R:L280	2.44	No	No	0	5	6
252	R:R:F167	R:R:L186	2.44	Yes	No	0	6	7
253	R:R:I256	R:R:Y257	2.42	No	Yes	1	5	7
254	R:R:I256	R:R:Y274	2.42	No	Yes	1	5	7
255	R:R:N136	R:R:R138	2.41	No	No	0	7	3
256	R:R:G108	R:R:G151	2.11	No	No	0	3	7
257	R:R:F261	R:R:Y192	2.06	Yes	No	0	4	3
258	R:R:R298	R:R:W301	2	No	No	0	4	2
259	R:R:G95	R:R:S92	1.86	No	No	0	5	9
260	R:R:G203	R:R:T258	1.82	No	No	0	3	6
261	R:R:P260	R:R:V198	1.77	No	No	0	7	4
262	R:R:G40	R:R:L39	1.71	No	No	0	7	5
263	R:R:A63	R:R:V48	1.7	No	No	0	5	7
264	R:R:A296	R:R:T47	1.68	No	No	0	8	5
265	R:R:C126	R:R:I125	1.64	No	No	0	8	9
266	R:R:L165	R:R:P166	1.64	No	No	0	7	5
267	R:R:C209	R:R:I205	1.64	No	No	0	6	4
268	R:R:S66	R:R:V45	1.62	No	No	0	9	7
269	R:R:S50	R:R:T49	1.6	No	No	0	3	1
270	R:R:T49	R:R:V45	1.59	No	No	0	1	7
271	R:R:A36	R:R:L280	1.58	No	No	0	3	6
272	R:R:A296	R:R:L54	1.58	No	Yes	0	8	9
273	R:R:A147	R:R:L113	1.58	No	No	0	6	7
274	R:R:A118	R:R:L213	1.58	No	No	0	9	8
275	R:R:A235	R:R:L221	1.58	No	No	0	9	5
276	R:R:A235	R:R:L224	1.58	No	No	0	9	5
277	R:R:T240	R:R:T244	1.57	No	No	0	5	5
278	R:R:I70	R:R:S74	1.55	No	No	0	5	7
279	R:R:I254	R:R:S206	1.55	No	No	0	4	3
280	R:R:I285	R:R:S241	1.55	No	No	0	9	9
281	R:R:I215	R:R:V219	1.54	No	No	0	3	3
282	R:R:I12	R:R:T90	1.52	No	No	0	6	4
283	R:R:K127	R:R:V123	1.52	No	No	0	4	7
284	R:R:I254	R:R:T258	1.52	No	No	0	4	6
285	R:R:F176	R:R:G15	1.51	Yes	No	0	6	8
286	R:R:L31	R:R:V35	1.49	No	No	0	5	4
287	R:R:L42	R:R:V46	1.49	No	No	0	3	4
288	R:R:N94	R:R:S92	1.49	No	No	0	2	9
289	R:R:L113	R:R:V144	1.49	No	Yes	0	7	5
290	R:R:L153	R:R:V149	1.49	No	No	0	3	2
291	R:R:N136	R:R:V139	1.48	No	No	0	7	4
292	R:R:L236	R:R:T240	1.47	No	No	0	7	5
293	R:R:L248	R:R:T278	1.47	No	No	0	5	8
294	R:R:E230	R:R:S228	1.44	No	No	0	4	9
295	R:R:F264	R:R:P265	1.44	Yes	No	0	3	3
296	R:R:Q164	R:R:V163	1.43	No	No	0	4	4
297	R:R:I254	R:R:L207	1.43	No	No	0	4	3
298	R:R:I243	R:R:L214	1.43	No	No	0	5	4
299	R:R:I285	R:R:L284	1.43	No	No	0	9	8
300	R:R:A271	R:R:F176	1.39	No	Yes	6	7	6
301	R:R:A271	R:R:F177	1.39	No	Yes	6	7	5
302	R:R:H227	R:R:S226	1.39	No	No	0	4	6
303	R:R:L204	R:R:L207	1.38	No	No	0	1	3
304	R:R:L221	R:R:L236	1.38	No	No	0	5	7
305	R:R:L284	R:R:L288	1.38	No	No	0	8	8
306	R:R:K89	R:R:Q18	1.36	No	No	0	5	3
307	R:R:L14	R:R:Q18	1.33	No	No	0	4	3
308	R:R:R88	R:R:S86	1.32	No	No	0	3	5
309	R:R:R303	R:R:S302	1.32	No	No	0	5	1
310	R:R:F27	R:R:V28	1.31	No	No	0	7	3
311	R:R:F269	R:R:V270	1.31	No	No	0	5	4
312	R:R:F261	R:R:T262	1.3	Yes	No	0	4	6
313	R:R:F264	R:R:T262	1.3	Yes	No	0	3	6
314	R:R:F273	R:R:I277	1.26	No	No	0	5	6
315	R:R:F152	R:R:L153	1.22	Yes	No	0	3	3
316	R:R:L288	R:R:R289	1.21	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F11	6.1725	4	0	9
2	R:R:L26	3.34	4	2	6
3	R:R:F30	5.3	4	0	6
4	R:R:Y34	8.645	4	0	8
5	R:R:N41	4.508	5	0	9
6	R:R:L54	6.6875	4	0	9
7	R:R:Y59	6.08167	6	0	9
8	R:R:D69	5.69	4	1	9
9	R:R:Y72	4.872	5	1	5
10	R:R:I91	3.642	5	4	9
11	R:R:Q99	3.2	4	4	9
12	R:R:F101	6.842	5	1	3
13	R:R:H104	4.985	6	1	4
14	R:R:F105	5.145	4	1	3
15	R:R:E110	3.86	6	1	8
16	R:R:M111	5.6	4	1	5
17	R:R:Y131	5.424	5	7	9
18	R:R:V144	4.8825	4	8	5
19	R:R:W148	4.02	6	0	5
20	R:R:F152	5.81	4	1	3
21	R:R:H154	5.5275	4	1	4
22	R:R:Q158	6.98	5	1	4
23	R:R:F167	3.19	7	3	6
24	R:R:F176	5.35167	6	6	6
25	R:R:F177	5.2575	4	6	5
26	R:R:D179	6.22	4	1	8
27	R:R:L180	4.486	5	1	5
28	R:R:N201	8.1075	4	1	3
29	R:R:S202	4.834	5	1	3
30	R:R:Y217	5.4075	4	9	9
31	R:R:H242	4.69	5	9	9
32	R:R:F249	5.905	4	1	6
33	R:R:F250	5.255	6	1	6
34	R:R:Y257	6.39833	6	1	7
35	R:R:F261	3.0375	4	0	4
36	R:R:F264	4.5825	4	10	3
37	R:R:Y274	3.59	5	1	7
38	R:R:N282	5.2175	4	1	9
39	L:L:?1	6.645	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F167	R:R:F93	13.6969	3.22	Yes	No	3	6	4
2	R:R:F11	R:R:I173	13.2007	8.79	Yes	No	0	9	7
3	R:R:I173	R:R:L13	15.5223	2.85	No	No	0	7	8
4	R:R:I91	R:R:L13	11.2183	2.85	Yes	No	0	9	8
5	R:R:F93	R:R:M97	16.2818	6.22	No	No	0	4	5
6	R:R:I162	R:R:M97	21.1327	4.37	No	No	0	5	5
7	R:R:I100	R:R:I162	20.12	4.42	No	No	1	5	5
8	R:R:H104	R:R:I100	22.4872	2.65	Yes	No	1	4	5
9	R:R:H104	R:R:L103	11.7803	5.14	Yes	No	1	4	4
10	R:R:L103	R:R:Y72	11.9677	5.86	No	Yes	1	4	5
11	R:R:F249	R:R:Y72	60.2562	3.09	Yes	Yes	1	6	5
12	R:R:E110	R:R:F249	100	4.66	Yes	Yes	1	8	6
13	R:R:D69	R:R:E110	48.3265	5.2	Yes	Yes	1	9	8
14	R:R:D69	R:R:N41	58.8663	4.04	Yes	Yes	0	9	9
15	R:R:N41	R:R:T37	44.62	2.92	Yes	No	0	9	7
16	R:R:L280	R:R:T37	43.2174	2.95	No	No	0	6	7
17	R:R:F33	R:R:L280	41.4148	2.44	No	No	0	5	6
18	R:R:F33	R:R:V276	38.6728	2.62	No	No	0	5	5
19	R:R:F30	R:R:V276	37.7487	2.62	Yes	No	0	6	5
20	R:R:F30	R:R:L26	15.097	4.87	Yes	Yes	0	6	6
21	L:L:?1	R:R:H104	27.0292	9.37	Yes	Yes	1	0	4
22	L:L:?1	R:R:Y72	33.3105	8.54	Yes	Yes	1	0	5
23	L:L:?1	R:R:M111	38.8096	4.12	Yes	Yes	1	0	5
24	R:R:F249	R:R:M111	35.8626	6.22	Yes	Yes	1	6	5
25	R:R:F176	R:R:M80	13.0007	8.71	Yes	No	0	6	6
26	R:R:F30	R:R:M80	14.0513	11.2	Yes	No	0	6	6
27	R:R:E110	R:R:N282	30.7028	3.94	Yes	Yes	1	8	9
28	R:R:E110	R:R:L65	32.9409	3.98	Yes	No	1	8	9
29	R:R:L65	R:R:M117	41.5591	2.83	No	No	0	9	9
30	R:R:L62	R:R:M117	34.3638	2.83	No	No	0	9	9
31	R:R:L62	R:R:M58	33.3156	2.83	No	No	0	9	9
32	R:R:M58	R:R:Y59	32.2624	3.59	No	Yes	0	9	9
33	R:R:L54	R:R:Y59	11.4791	9.38	Yes	Yes	0	9	9
34	R:R:S56	R:R:Y59	15.1071	5.09	No	Yes	0	7	9
35	R:R:P57	R:R:S56	13.9678	3.56	No	No	0	9	7
36	R:R:P57	R:R:Y131	11.674	5.56	No	Yes	0	9	9
37	R:R:I173	R:R:P182	28.4394	3.39	No	No	0	7	7
38	R:R:P181	R:R:P182	29.6876	5.84	No	No	0	4	7
39	R:R:P181	R:R:Y257	28.5736	4.17	No	Yes	1	4	7
40	R:R:Y257	R:R:Y274	11.0183	3.97	Yes	Yes	1	7	7
41	L:L:?1	R:R:H154	11.3348	5.62	Yes	Yes	1	0	4
42	R:R:N282	R:R:Y286	34.741	5.81	Yes	No	0	9	9
43	R:R:H242	R:R:Y286	33.6701	6.53	Yes	No	0	9	9
44	R:R:H242	R:R:Y217	21.8821	4.36	Yes	Yes	9	9	9
45	R:R:A235	R:R:L224	11.7727	1.58	No	No	0	9	5
46	R:R:A235	R:R:L221	12.9272	1.58	No	No	0	9	5
47	R:R:C239	R:R:L221	17.5123	3.17	No	No	0	9	5
48	R:R:C239	R:R:Y217	18.644	4.03	No	Yes	0	9	9
49	R:R:I157	R:R:N201	13.1475	5.66	No	Yes	0	4	3
50	R:R:I157	R:R:L197	11.2841	4.28	No	No	0	4	4
51	R:R:F261	R:R:P260	13.8235	5.78	Yes	No	0	4	7
52	R:R:P260	R:R:V198	18.0971	1.77	No	No	0	7	4
53	R:R:Y274	R:R:Y72	15.1653	3.97	Yes	Yes	1	7	5
54	L:L:?1	R:R:Y257	20.5985	13.67	Yes	Yes	1	0	7
55	R:R:H104	R:R:Q158	14.1602	6.18	Yes	Yes	1	4	4
56	L:L:?1	R:R:S202	15.7679	4.38	Yes	Yes	1	0	3
57	R:R:Q158	R:R:V198	18.8339	4.3	Yes	No	1	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L103	R:R:Y72	5.86	1	No	Yes	4	5	1	1
R:R:G107	R:R:Y72	2.9	0	No	Yes	5	5	2	1
R:R:F249	R:R:Y72	3.09	1	Yes	Yes	6	5	2	1
R:R:Y274	R:R:Y72	3.97	1	Yes	Yes	7	5	1	1
L:L:?1	R:R:Y72	8.54	1	Yes	Yes	0	5	0	1
R:R:H104	R:R:I100	2.65	1	Yes	No	4	5	1	2
R:R:H104	R:R:L103	5.14	1	Yes	No	4	4	1	1
L:L:?1	R:R:L103	4.04	1	Yes	No	0	4	0	1
R:R:H104	R:R:S155	2.79	1	Yes	No	4	5	1	2
R:R:H104	R:R:Q158	6.18	1	Yes	Yes	4	4	1	2
R:R:D179	R:R:H104	3.78	1	Yes	Yes	8	4	2	1
L:L:?1	R:R:H104	9.37	1	Yes	Yes	0	4	0	1
R:R:G108	R:R:H154	4.77	0	No	Yes	3	4	2	1
R:R:M111	R:R:S206	4.6	1	Yes	No	5	3	1	2
R:R:F249	R:R:M111	6.22	1	Yes	Yes	6	5	2	1
R:R:F250	R:R:M111	7.46	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:M111	4.12	1	Yes	Yes	0	5	0	1
R:R:H154	R:R:N201	8.93	1	Yes	Yes	4	3	1	2
R:R:H154	R:R:S202	2.79	1	Yes	Yes	4	3	1	1
L:L:?1	R:R:H154	5.62	1	Yes	Yes	0	4	0	1
R:R:N201	R:R:Q158	11.88	1	Yes	Yes	3	4	2	2
R:R:Q158	R:R:S202	7.22	1	Yes	Yes	4	3	2	1
R:R:D179	R:R:P181	8.05	1	Yes	No	8	4	2	2
R:R:D179	R:R:Y257	10.34	1	Yes	Yes	8	7	2	1
R:R:P181	R:R:Y257	4.17	1	No	Yes	4	7	2	1
R:R:N201	R:R:S202	5.96	1	Yes	Yes	3	3	2	1
R:R:S202	R:R:Y257	3.82	1	Yes	Yes	3	7	1	1
L:L:?1	R:R:S202	4.38	1	Yes	Yes	0	3	0	1
R:R:F249	R:R:F250	9.65	1	Yes	Yes	6	6	2	2
R:R:P252	R:R:Y274	4.17	0	No	Yes	7	7	2	1
R:R:Y257	R:R:Y274	3.97	1	Yes	Yes	7	7	1	1
L:L:?1	R:R:Y257	13.67	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y274	3.42	1	Yes	Yes	0	7	0	1
R:R:I256	R:R:Y257	2.42	1	No	Yes	5	7	2	1
R:R:I256	R:R:Y274	2.42	1	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UYQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	279
Number of Links	316
Number of Hubs	39
Number of Links mediated by Hubs	148
Number of Communities	10
Number of Nodes involved in Communities	65
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	64071
Length Of Smallest Path	3
Average Path Length	14.2251
Length of Longest Path	29
Minimum Path Strength	1.295
Average Path Strength	4.48897
Maximum Path Strength	11.57
Minimum Path Correlation	0.7
Average Path Correlation	0.937002
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	52.4432
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.211
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	XVT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XVT
Name	(2R)-2-methyl-1,3-thiazolidine
Synonyms
Identifier
Formula	C4 H9 N S
Molecular Weight	103.186
SMILES
PubChem	6999028
Formal Charge	0
Total Atoms	15
Total Chiral Atoms	1
Total Bonds	15
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Cons
Sequence	>8UYQ_nogp_Chain_R F P L T P H S N V T E F I L L G L T Q S P E Q L F L F V V F L L F Y V A T V G N L L I V V T V T S D P H L H S P M Y F L A N L S F I D I C Y S S V T A P K M I V D L L S E R K T I S F N G C M T Q I L H F F G G A E M F L L V V M A Y D R Y V A I C K P L H Y L T I M N R R V C V L L V A V A W V G G F L H S I I Q L A F I V Q L F C G P N V I D S F F C D P P V L K L A C T D T Y V L G L L V I A N G I S C F L L L L I S Y V I L V S L R S H S E G R K A L T C S H T V V I L F F G P C I F I Y R P F T T F P M D K V A F Y T V I T L N P I Y T L R N K E K A A M R K L W S R K V I S S R K L L L F S L L L V S S S I T F V L L M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UYQ	O2	Odorant receptors	Odorant family 4	consOR4	Homo sapiens	2-methylthiazoline	-	Gs/β1/γ2	3.5	2024-10-30	doi.org/10.1038/s41586-024-08126-0
	8UYQ (No Gprot)	O2	Odorant receptors	Odorant family 4	consOR4	Homo sapiens	2-methylthiazoline	-		3.5	2024-10-30	doi.org/10.1038/s41586-024-08126-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8UYQ_nogp.zip

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