Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L23 4.25476
2A:A:E28 5.1375404
3A:A:V34 6.5525105
4A:A:I49 3.76754167
5A:A:I184 3.3025419
6A:A:F191 8.78754105
7A:A:L194 5.5354104
8A:A:F196 9.1354107
9A:A:K197 7.8725416
10A:A:F199 8.69333615
11A:A:Q204 4.855419
12A:A:E207 5.162519
13A:A:K210 6.09571719
14A:A:W211 5.516519
15A:A:H213 7.53418
16A:A:C214 5.1675417
17A:A:F215 7.028519
18A:A:I221 4.724208
19A:A:I222 3.674167
20A:A:V225 4.67497
21A:A:S228 6.815409
22A:A:Y230 6.02738
23A:A:D231 9.8225439
24A:A:R242 3.96409
25A:A:F250 7.398599
26A:A:C254 3.90167695
27A:A:W258 9.26167615
28A:A:F259 6.94254209
29A:A:I265 3.875168
30A:A:L266 6.286599
31A:A:F267 5.388336169
32A:A:L268 5.416598
33A:A:N269 5.2254169
34A:A:F274 4.1025409
35A:A:K277 6.2025439
36A:A:S281 5.4625437
37A:A:L283 6.1175437
38A:A:C286 5.138536
39A:A:Y287 7737
40A:A:Y302 8.6025436
41A:A:N311 6.8475498
42A:A:E318 6.84684
43A:A:I319 4.5975495
44A:A:Y320 8.655487
45A:A:T321 7.9175495
46A:A:C325 2.7975407
47A:A:Q333 6.35254105
48A:A:F336 6.66108
49A:A:V339 4.9454108
50A:A:D341 7.4325488
51A:A:K345 6.5075485
52A:A:K349 4.48485
53A:A:L353 6.5554217
54A:A:F354 4.84485
55B:B:E3 3.244225
56B:B:L7 3.7485228
57B:B:I18 3.675407
58B:B:I37 4.5185132
59B:B:V40 4.3165133
60B:B:M45 5.0825464
61B:B:H54 8.665679
62B:B:L55 4.0525466
63B:B:Y59 11.114518
64B:B:M61 3.9575406
65B:B:W63 7.418507
66B:B:V71 4.98448
67B:B:S74 5.8675479
68B:B:Q75 9.43419
69B:B:L79 6.4475447
70B:B:I80 10.025478
71B:B:I81 4.908547
72B:B:W82 11.0143779
73B:B:N88 8.13407
74B:B:K89 7.895679
75B:B:H91 6.345445
76B:B:I93 8.8075447
77B:B:L95 5.21448
78B:B:W99 7.48667619
79B:B:Y105 5.02846
80B:B:N110 6.915414
81B:B:Y111 5.976514
82B:B:V112 4.266548
83B:B:L117 3.5875419
84B:B:N119 5.35419
85B:B:I123 3.58616
86B:B:Y124 5.71143746
87B:B:L126 4.85445
88B:B:T128 4.985413
89B:B:E130 3.8475413
90B:B:V133 6.4825444
91B:B:H142 6.995619
92B:B:Y145 6.15714718
93B:B:L146 3.35417
94B:B:F151 5.598519
95B:B:I157 4.9425417
96B:B:V158 5.078505
97B:B:T159 4.88333619
98B:B:D163 9.06519
99B:B:C166 3.81458
100B:B:L168 4.4425456
101B:B:W169 9.20333618
102B:B:F180 9.492557
103B:B:H183 9.34667659
104B:B:D186 6.996519
105B:B:V187 4.086559
106B:B:F199 10.66459
107B:B:V200 9.1525416
108B:B:S201 4.915459
109B:B:C204 6.276517
110B:B:D205 6.656559
111B:B:K209 12.8825456
112B:B:L210 6.6405
113B:B:W211 9.88833658
114B:B:Q220 8.375417
115B:B:F222 6.13518
116B:B:H225 8.75857719
117B:B:D228 8.164519
118B:B:I232 5.725418
119B:B:F234 6.7625405
120B:B:F235 7.098336176
121B:B:P236 6.36254177
122B:B:F241 8.77833616
123B:B:T243 6.6025418
124B:B:D246 6.48419
125B:B:D247 8.456519
126B:B:T249 7.9375416
127B:B:R251 12.708518
128B:B:F253 7.36333616
129B:B:D258 9.02517
130B:B:Q259 5.0875406
131B:B:E260 9.74416
132B:B:M262 7.3575404
133B:B:T263 5.615411
134B:B:Y264 6.9505
135B:B:I269 4.77754154
136B:B:F278 5.8156177
137B:B:R283 7.8585139
138B:B:L285 4.79406
139B:B:Y289 7.445717157
140B:B:N295 9.01254156
141B:B:W297 6.7954158
142B:B:L300 5.8665136
143B:B:K301 5.75405
144B:B:R304 6.7054155
145B:B:H311 9.935469
146B:B:R314 15.22418
147B:B:V327 3.9575406
148B:B:T329 4.7325408
149B:B:W332 10.9738819
150B:B:D333 9.3075469
151B:B:F335 6.3475464
152B:B:L336 4.16677
153B:B:K337 7.816566
154B:B:W339 10.32669
155G:G:L19 2.8425409
156G:G:R27 6.9125418
157G:G:I28 3.77404
158G:G:M38 2.924134
159G:G:Y40 9.4754176
160G:G:D48 7.35409
161G:G:P49 4.695407
162G:G:L51 3.025136
163G:G:P60 6.4054149
164G:G:F61 5.631119148
165R:R:M43 4.74525
166R:R:F47 5.808527
167R:R:G57 3.495407
168R:R:C74 3.5325468
169R:R:V77 4.16754196
170R:R:P78 2.814198
171R:R:D79 4.3125408
172R:R:F81 5.6407
173R:R:D89 6.746509
174R:R:F92 7.175627
175R:R:M96 6.992527
176R:R:I100 5.825426
177R:R:M104 4.715425
178R:R:W109 6.033758188
179R:R:I119 4.86405
180R:R:N125 7.26254115
181R:R:F128 5.8025116
182R:R:T129 6.5845117
183R:R:M137 4.2825409
184R:R:R141 9.03754219
185R:R:R155 6.4025196
186R:R:P199 6.4354124
187R:R:N200 5.7254124
188R:R:D204 8.0154122
189R:R:F217 6.3175428
190R:R:P220 3.29254249
191R:R:Y228 6.9956219
192R:R:M235 6.2225488
193R:R:I247 3.28404
194R:R:R250 6.35857786
195R:R:F265 5.11254249
196R:R:W269 7.81628
197R:R:Y272 5.964527
198R:R:Y273 5.964528
199R:R:Q276 8.0175425
200R:R:F289 3.7775404
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:G319 B:B:M61 21.20633.49NoYes056
2B:B:G319 B:B:S277 21.27923.71NoNo055
3B:B:S277 B:B:V320 31.88114.85NoNo057
4B:B:V320 B:B:V327 31.93743.21NoYes076
5B:B:V327 B:B:W339 32.62443.68YesYes069
6B:B:T329 B:B:W339 18.12158.49YesYes089
7B:B:H311 B:B:T329 69.82344.11YesYes098
8B:B:D333 B:B:H311 84.991315.13YesYes699
9B:B:D333 B:B:F335 84.686611.94YesYes694
10B:B:F335 R:R:K70 1004.96YesNo646
11B:B:L55 R:R:K70 99.87852.82YesNo666
12B:B:L55 R:R:C74 99.13694.76YesYes668
13A:A:E28 R:R:C74 98.72593.04YesYes048
14B:B:K337 B:B:W339 32.17279.28YesYes669
15B:B:H311 B:B:K337 16.43276.55YesYes696
16B:B:K337 B:B:T50 16.56113YesNo063
17B:B:R52 B:B:T50 16.402611.64NoNo073
18B:B:F335 B:B:R52 16.16973.21YesNo047
19A:A:E28 R:R:P157 97.39824.72YesNo041
20B:B:W332 B:B:Y59 18.461715.43YesYes198
21R:R:P157 R:R:V77 92.26243.53NoYes016
22R:R:R155 R:R:V77 30.00545.23YesYes1966
23R:R:A144 R:R:R155 31.0395.53NoYes086
24A:A:N347 R:R:A144 30.81634.69NoNo088
25A:A:I343 A:A:N347 30.59354.25NoNo078
26A:A:I343 A:A:V339 30.37123.07NoYes078
27A:A:V339 A:A:V34 12.01318.02YesYes1085
28A:A:F196 A:A:V339 10.92983.93YesYes1078
29A:A:F215 A:A:L37 27.415415.83YesNo099
30A:A:N256 A:A:W258 15.55745.65NoYes085
31A:A:F259 A:A:N256 15.46113.62YesNo098
32A:A:F259 A:A:I221 15.179510.05YesYes2098
33A:A:I221 A:A:L39 26.56782.85YesNo089
34A:A:H213 B:B:W332 16.69838.46YesYes189
35A:A:C214 A:A:H213 31.76484.42YesYes178
36A:A:C214 B:B:M101 48.39923.24YesNo079
37B:B:M101 B:B:Y145 48.10375.99NoYes098
38A:A:Q204 B:B:Y145 10.18093.38YesYes198
39A:A:C214 B:B:Y59 16.70945.38YesYes178
40B:B:D83 B:B:L69 22.26554.07NoNo085
41B:B:L69 B:B:Y105 21.91495.86NoYes056
42B:B:H62 B:B:Y105 15.06553.27NoYes066
43B:B:H62 B:B:R150 14.918613.54NoNo066
44B:B:C148 B:B:T102 23.6383.38NoNo068
45B:B:C149 B:B:T102 23.97356.76NoNo088
46B:B:C149 B:B:T159 24.31963.38NoYes089
47B:B:H142 B:B:T159 33.49316.85YesYes199
48A:A:F215 A:A:W211 19.36084.01YesYes199
49B:B:M188 B:B:Y145 44.71198.38NoYes188
50A:A:K210 B:B:M188 44.01354.32YesNo198
51A:A:K210 B:B:D246 52.32835.53YesYes199
52A:A:I221 A:A:I264 40.67332.94YesNo086
53A:A:C254 A:A:I264 40.49363.27YesNo056
54A:A:C254 A:A:F250 27.88664.19YesYes959
55A:A:F250 A:A:L266 10.1599.74YesYes999
56A:A:C254 A:A:I319 10.32623.27YesYes955
57A:A:I319 A:A:L266 10.17212.85YesYes959
58A:A:F250 A:A:F307 17.5495.36YesNo098
59A:A:L266 A:A:L268 17.93985.54YesYes998
60A:A:K277 A:A:Y230 12.02084.78YesYes398
61A:A:F274 A:A:Y230 12.43247.22YesYes098
62A:A:F274 A:A:L227 13.61733.65YesNo097
63A:A:L227 A:A:L268 15.58128.3NoYes078
64A:A:M247 A:A:Y287 16.58337.18NoYes067
65A:A:F307 A:A:M247 16.97256.22NoNo086
66A:A:L232 A:A:R242 11.22256.07NoYes089
67B:B:R314 B:B:W332 33.080622.99YesYes189
68R:R:D140 R:R:V77 61.74614.38NoYes1986
69R:R:D140 R:R:F81 63.58188.36NoYes087
70R:R:F81 R:R:M137 62.62213.73YesYes079
71R:R:M137 R:R:R141 14.03496.2YesYes099
72R:R:R141 R:R:Y228 12.20688.23YesYes2199
73B:B:C233 B:B:S277 15.47183.44NoNo035
74B:B:C233 B:B:F278 15.29215.59NoYes037
75B:B:F235 B:B:F278 12.0638.57YesYes1767
76B:B:F235 B:B:N237 10.176610.87YesNo1765
77B:B:N237 B:B:N239 10.00048.17NoNo052
78B:B:I18 B:B:R22 11.66416.26YesNo076
79B:B:I18 G:G:L19 16.71321.43YesYes079
80B:B:A11 G:G:L19 13.68071.58NoYes059
81B:B:A11 G:G:V16 12.92221.7NoNo057
82B:B:E10 G:G:V16 12.16345.7NoNo087
83B:B:D258 B:B:R22 13.22310.72YesNo076
84B:B:D83 B:B:R68 22.06214.29NoNo085
85B:B:R68 B:B:Y85 22.377528.81NoNo054
86B:B:Y85 G:G:P60 10.785411.13NoYes1449
87B:B:M325 G:G:P60 11.07886.71NoYes059
88B:B:M325 G:G:P49 12.02218.39NoYes057
89G:G:D48 G:G:P49 12.35954.83YesYes097
90G:G:D48 G:G:L51 12.42115.43YesYes096
91B:B:V40 G:G:L51 12.61162.98YesYes1336
92B:B:I43 B:B:V40 15.95493.07NoYes033
93B:B:M45 B:B:W339 16.61254.65YesYes649
94B:B:Y85 G:G:F61 11.91355.16NoYes1448
95B:B:S84 B:B:W63 13.63514.94NoYes057
96B:B:S84 G:G:F61 13.44925.28NoYes058
97B:B:F151 B:B:I157 15.67618.79YesYes197
98B:B:F151 B:B:Y111 11.9273.09YesYes194
99B:B:N125 B:B:Y111 11.113810.47NoYes144
100B:B:H142 B:B:S161 50.937612.55YesNo199
101B:B:G162 B:B:Y145 35.04918.69NoYes198
102B:B:G162 B:B:S161 53.07263.71NoNo199
103B:B:C148 B:B:L190 16.58637.94NoNo065
104B:B:D246 B:B:S227 61.35112.94YesNo196
105B:B:S227 B:B:S245 28.80974.89NoNo169
106B:B:H225 B:B:S245 28.50539.76YesNo199
107B:B:H225 B:B:T243 10.33068.21YesYes198
108B:B:D247 B:B:S227 32.25017.36YesNo196
109B:B:D247 B:B:H225 28.51997.56YesYes199
110B:B:F253 B:B:H225 41.72514.53YesYes169
111B:B:F241 B:B:F253 13.851511.79YesYes166
112B:B:L198 B:B:L210 12.61385.54NoYes035
113B:B:F222 B:B:F253 25.57627.5YesYes186
114B:B:D212 B:B:L198 10.09145.43NoNo093
115B:B:R314 B:B:T274 56.84273.88YesNo088
116B:B:S275 B:B:T274 56.73153.2NoNo088
117B:B:L318 B:B:S275 56.63517.51NoNo068
118B:B:L318 B:B:T329 56.58322.95NoYes068
119R:R:L85 R:R:M137 49.46012.83NoYes099
120R:R:D89 R:R:L85 38.29114.07YesNo099
121R:R:D89 R:R:S304 26.675911.78YesNo099
122R:R:F92 R:R:S304 25.31497.93YesNo079
123R:R:W269 R:R:Y272 12.54274.82YesYes287
124R:R:I133 R:R:L85 12.00737.14NoNo089
125R:R:I133 R:R:T129 11.76533.04NoYes087
126B:B:I43 B:B:M45 16.39934.37NoYes034
127B:B:H142 B:B:W169 17.86713.17YesYes198
128A:A:W258 B:B:R314 27.2099YesYes158
129A:A:L37 A:A:L39 27.21749.69NoNo099
130A:A:H213 A:A:W258 15.18686.35YesYes185
131B:B:M61 B:B:W63 15.77024.65YesYes067
132A:A:Q204 A:A:W211 11.12446.57YesYes199
133B:B:L117 B:B:Y145 17.61463.52YesYes198
134B:B:D258 B:B:F222 20.1794.78YesYes178
135B:B:D186 B:B:G162 18.36525.03YesNo199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WWI
Class A
SubFamily Peptide
Type Melanin Concentrating Hormone
SubType MCH1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.43
Date 2024-11-13
D.O.I. To be published
Net Summary
Imin 2.82
Number of Linked Nodes 856
Number of Links 1100
Number of Hubs 200
Number of Links mediated by Hubs 691
Number of Communities 24
Number of Nodes involved in Communities 285
Number of Links involved in Communities 449
Path Summary
Number Of Nodes in MetaPath 136
Number Of Links MetaPath 135
Number of Shortest Paths 2159102
Length Of Smallest Path 3
Average Path Length 29.1822
Length of Longest Path 55
Minimum Path Strength 1.31
Average Path Strength 6.15224
Maximum Path Strength 24
Minimum Path Correlation 0.7
Average Path Correlation 0.984402
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 44.048
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.7836
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • signaling receptor binding   • neuropeptide binding   • peptide binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • neuropeptide receptor activity   • melanin-concentrating hormone receptor activity   • protein-hormone receptor activity   • hormone binding   • neuropeptide signaling pathway   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell surface receptor signaling pathway   • regulation of localization   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • transport   • regulation of transport   • regulation of monoatomic ion transport   • positive regulation of biological process   • establishment of localization   • calcium ion transport   • metal ion transport   • localization   • positive regulation of transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • monoatomic cation transport   • regulation of metal ion transport   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • metabolic process   • generation of precursor metabolites and energy   • behavior   • feeding behavior   • ciliary membrane   • plasma membrane region   • cell projection membrane
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8WWI_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLAEDEEM NRMHSMKLF DSICNNKWF TDTSIILFL 
NKKDLFEEK IKKSPLTIC YPEYAGSNT YEEAAAYIQ CQFEDLNKR 
KDTKEIYTH FTCTDTKNV QFVFDAVTD VIIKNNLKD CGLFNAAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8WWI_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8WWI_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99705
Sequence
>8WWI_Chain_R
YINIIMPSV FGTICLLGI IGNSTVIFA VVKKSKLHW CNNVPDIFI 
INLSVVDLL FLLGMPFMI HQLMGNGVW HFGETMCTL ITAMDANSQ 
FTSTYILTA MAIDRYLAT VHPISSTKF RKPSVATLV ICLLWALSF 
ISITPVWLY ARLIPFPGG AVGCGIRLP NPDTDLYWF TLYQFFLAF 
ALPFVVITA AYVRILQRM TSSVAPASQ RSIRLRTKR VTRTAIAIC 
LVFFVCWAP YYVLQLTQL SISRPTLTF VYLYNAAIS LGYANSCLN 
PFVYIVLCE TFRKRLVLS V


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WWNAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.652024-11-13To be published
8WWMAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.812024-11-13To be published
8WWLAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.782024-11-13To be published
8WWKAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.612024-11-13To be published
8WWJAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.032024-11-13To be published
8WWIAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.432024-11-13To be published
8WWHAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ22.842024-11-13To be published
8WSSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensPro-MCH-Gi1/β1/γ13.012024-06-1910.1038/s41421-024-00679-8
8YNTAPeptideMelanin Concentrating HormoneMCH1Homo sapiensSNAP-94847--3.432024-12-1810.1038/s41421-024-00754-0
8YNSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensSNAP-94847--3.332024-12-1810.1038/s41421-024-00754-0




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