Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L23 3.54446
2A:A:V34 6.25145
3A:A:L37 6.866519
4A:A:L39 4.99419
5A:A:K46 4.7825409
6A:A:I49 4.43754127
7A:A:M53 5.06408
8A:A:F191 8.87254145
9A:A:L194 5.5725144
10A:A:H195 8.795414
11A:A:F196 8.4025147
12A:A:K197 8.3075416
13A:A:M198 3.5825407
14A:A:F199 10.15415
15A:A:V201 4.335419
16A:A:Q204 5.73419
17A:A:S206 5.38418
18A:A:E207 5.9175419
19A:A:K210 5.42719
20A:A:W211 5.31286719
21A:A:H213 6.875418
22A:A:F215 8.618519
23A:A:I221 4.3825418
24A:A:I222 3.3825127
25A:A:V225 5.385407
26A:A:S228 7.19439
27A:A:D229 6.108538
28A:A:Y230 6.05857738
29A:A:L232 5.255438
30A:A:L234 3.8675438
31A:A:R242 6.5775439
32A:A:M243 3.4675438
33A:A:F250 5.6856159
34A:A:C254 4.645155
35A:A:W258 9.09167615
36A:A:F259 6.585419
37A:A:I265 3.30254128
38A:A:F267 4.945569129
39A:A:L268 6.2538
40A:A:N269 4.935129
41A:A:K270 4.764539
42A:A:L273 5.03436
43A:A:F274 4.588539
44A:A:K277 5.5975439
45A:A:I278 4.0275436
46A:A:S281 4.7275437
47A:A:C286 5.5536
48A:A:Y287 6.34857737
49A:A:Y290 9.15407
50A:A:Y296 6.10667634
51A:A:Y302 9.3675436
52A:A:N311 6.7954158
53A:A:E318 6.5225884
54A:A:Y320 5.89429787
55A:A:T321 9.3475435
56A:A:F323 5.048534
57A:A:T324 8.41754129
58A:A:C325 2.7975407
59A:A:F336 5.783336148
60A:A:D341 7.046588
61A:A:V342 2.9175487
62A:A:K345 8.34485
63A:A:L353 4.326676207
64A:A:F354 5.702585
65B:B:E3 2.91405
66B:B:L7 3.445408
67B:B:I18 3.486507
68B:B:L30 4.6925405
69B:B:T34 4.19525
70B:B:I37 4.518522
71B:B:V40 5.6425423
72B:B:I43 3.38423
73B:B:M45 4.7825424
74B:B:L51 8.63449
75B:B:H54 9.40667649
76B:B:Y59 9.692518
77B:B:M61 4.476546
78B:B:W63 6.36286747
79B:B:L70 7.005445
80B:B:V71 4.35468
81B:B:D76 5.872549
82B:B:K78 7.3025408
83B:B:L79 5.538567
84B:B:I80 9.3675448
85B:B:I81 5.005467
86B:B:W82 10.3686749
87B:B:D83 8.114188
88B:B:N88 6.1585187
89B:B:K89 6.81857749
90B:B:H91 6.31405
91B:B:I93 7.185467
92B:B:L95 5.21468
93B:B:W99 8.31143719
94B:B:Y105 4.82125866
95B:B:N110 7.275414
96B:B:Y111 6.41414
97B:B:V112 4.518568
98B:B:C114 4.58468
99B:B:C121 4.5325418
100B:B:I123 4.07833616
101B:B:Y124 5.55429766
102B:B:L126 4.21565
103B:B:T128 5.19754213
104B:B:E130 4.91254213
105B:B:V133 6.8275464
106B:B:E138 6.2175466
107B:B:L139 6.7125409
108B:B:H142 6.67333619
109B:B:Y145 6.55875818
110B:B:L146 3.8875417
111B:B:C149 4.25418
112B:B:F151 6.566509
113B:B:L152 4.1725403
114B:B:Q156 6.0775405
115B:B:I157 5.69517
116B:B:V158 4.245405
117B:B:T159 5.12833619
118B:B:D163 8.4425419
119B:B:C166 4.235478
120B:B:L168 4.618576
121B:B:W169 10.0633618
122B:B:Q176 7.62414
123B:B:F180 8.75577
124B:B:H183 7.90571779
125B:B:D186 6.624519
126B:B:V187 4.702579
127B:B:F199 9.675479
128B:B:V200 7.57456
129B:B:S201 5.2625479
130B:B:C204 5.78833617
131B:B:D205 7.4325479
132B:B:K209 11.5725476
133B:B:L210 6.255405
134B:B:W211 9.31333678
135B:B:Q220 8.375457
136B:B:F222 6.94667658
137B:B:H225 8.56125859
138B:B:D228 7.8675419
139B:B:I232 5.405458
140B:B:F234 5.4275405
141B:B:F235 6.15375826
142B:B:P236 6.015427
143B:B:N237 9.4275425
144B:B:F241 9.528556
145B:B:T243 7.685458
146B:B:D247 8.398559
147B:B:T249 5.742556
148B:B:R251 11.052558
149B:B:F253 7.48833656
150B:B:D254 5.0775409
151B:B:D258 9.732557
152B:B:Q259 5.4675406
153B:B:M262 7.0575404
154B:B:Y264 7.432505
155B:B:I269 3.8965164
156B:B:F278 6.388527
157B:B:R283 7.85667629
158B:B:L284 5525
159B:B:L285 5.4426
160B:B:Y289 7.055717167
161B:B:D290 9.4406
162B:B:N295 6.73254166
163B:B:V296 4.4925425
164B:B:W297 5.69754168
165B:B:L300 5.762526
166B:B:K301 5.2525
167B:B:L308 9.3775427
168B:B:H311 9.066529
169B:B:M325 5.02445
170B:B:W332 13.6057719
171B:B:F335 7.664524
172B:B:L336 4.92647
173B:B:K337 8.2475426
174B:B:W339 7.87167629
175B:B:N340 8.33449
176G:G:K20 3.4175406
177G:G:R27 7.5075458
178G:G:I28 4.1325404
179G:G:L37 3.37427
180G:G:M38 3.6725424
181G:G:Y40 10.7425426
182G:G:D48 6.04629
183G:G:P49 3.9225407
184G:G:L50 3.94429
185G:G:L51 3.85667626
186G:G:N59 6.1575449
187G:G:P60 7.1125449
188G:G:F61 5.545848
189R:R:M43 4.9885135
190R:R:F47 6.3154137
191R:R:G57 3.495407
192R:R:V77 4.1325406
193R:R:P78 6.2725408
194R:R:F81 5.92407
195R:R:L85 4.525409
196R:R:D89 7.29509
197R:R:F92 8.594137
198R:R:M96 5.4185137
199R:R:M104 4.7854135
200R:R:W109 6.491676178
201R:R:C116 4.0154179
202R:R:I119 4.2325405
203R:R:N125 6.465115
204R:R:F128 5.56754116
205R:R:T129 7.3125117
206R:R:M137 5.785409
207R:R:R141 8.36254209
208R:R:Y142 6.95254228
209R:R:H147 4.764226
210R:R:S151 3.425406
211R:R:R155 6.445406
212R:R:I175 4.6354117
213R:R:T176 2.9025494
214R:R:P177 5.0325498
215R:R:C194 4.69254179
216R:R:L198 3.606595
217R:R:N200 5.39494
218R:R:D204 6.858592
219R:R:W207 5.0575495
220R:R:F208 4.538595
221R:R:Y211 4.815493
222R:R:F213 6.8154105
223R:R:F217 5.994108
224R:R:Y228 5.813336209
225R:R:I247 3.806584
226R:R:R250 7.004586
227R:R:R253 6.9025487
228R:R:F265 4.6565109
229R:R:W269 7.611676108
230R:R:Y272 6.7645107
231R:R:Y273 6.5685108
232R:R:Q276 8.94105
233R:R:F289 3.2725404
234R:R:Y293 6.14754103
235R:R:N303 8.08754109
236R:R:L314 4.0925407
237R:R:F318 5.9975408
238R:R:R321 5.625405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N256 A:A:W258 15.115.65NoYes085
2A:A:F259 A:A:N256 15.15896.04YesNo098
3A:A:F259 A:A:I221 14.43358.79YesYes198
4A:A:I221 A:A:L39 15.67162.85YesYes189
5A:A:G40 A:A:L39 89.91541.71NoYes099
6A:A:G40 A:A:K46 89.90933.49NoYes099
7A:A:K46 A:A:L38 1007.05YesNo098
8A:A:L38 A:A:M198 47.51015.65NoYes087
9A:A:L36 A:A:M198 46.65452.83NoYes077
10A:A:L36 A:A:V34 93.48682.98NoYes075
11A:A:L194 A:A:V34 46.57454.47YesYes1445
12A:A:I343 A:A:L194 45.90072.85NoYes074
13A:A:I343 A:A:N347 91.3454.25NoNo078
14A:A:N347 R:R:A144 91.07444.69NoNo088
15R:R:A144 R:R:R155 90.80766.91NoYes086
16R:R:P78 R:R:R155 18.24012.88YesYes086
17A:A:I222 A:A:L38 52.48522.85YesNo078
18A:A:I222 A:A:L36 46.96344.28YesNo077
19A:A:V339 A:A:V34 45.75068.02NoYes1485
20A:A:I343 A:A:V339 45.7153.07NoNo078
21R:R:D140 R:R:R155 68.57510.72NoYes086
22A:A:F215 A:A:L37 39.982415.83YesYes199
23A:A:K46 A:A:S44 13.45113.06YesNo099
24A:A:A226 A:A:S44 13.35381.71NoNo089
25A:A:F215 A:A:W211 35.76694.01YesYes199
26B:B:C148 B:B:T102 11.74033.38NoNo068
27B:B:H142 B:B:T159 12.65026.85YesYes199
28B:B:H142 B:B:S161 17.284712.55YesNo199
29B:B:G162 B:B:S161 18.20493.71NoNo199
30B:B:G162 B:B:Y145 17.98368.69NoYes198
31A:A:K210 B:B:Y145 53.88033.58YesYes198
32A:A:K210 B:B:D228 26.62096.91YesYes199
33A:A:K210 B:B:N230 26.62115.6YesNo099
34A:A:C351 R:R:P78 10.46985.65NoYes048
35A:A:C351 R:R:R141 10.19975.57NoYes049
36R:R:D140 R:R:F81 64.27087.17NoYes087
37R:R:F81 R:R:M137 61.82637.46YesYes079
38B:B:C148 B:B:L190 12.40397.94NoNo065
39B:B:I18 G:G:L19 18.88481.43YesNo079
40B:B:L14 G:G:L19 16.31145.54NoNo089
41B:B:L14 G:G:K20 15.45342.82NoYes086
42B:B:E10 G:G:K20 12.87934.05NoYes086
43B:B:E10 B:B:L7 10.30461.33NoYes088
44B:B:I18 B:B:R22 13.06896.26YesNo076
45B:B:I18 G:G:R27 12.05373.76YesYes078
46B:B:D258 B:B:R22 14.513313.1YesNo076
47B:B:D258 G:G:R27 12.626910.72YesYes578
48B:B:D258 B:B:F222 27.18153.58YesYes578
49B:B:D228 B:B:D246 26.93223.99YesNo099
50B:B:D246 B:B:S227 53.21792.94NoNo096
51B:B:S227 B:B:S245 25.7164.89NoNo569
52B:B:H225 B:B:S245 25.505312.55YesNo599
53B:B:D246 B:B:N230 26.512913.46NoNo099
54B:B:D247 B:B:S227 27.29227.36YesNo596
55B:B:D247 B:B:H225 25.52697.56YesYes599
56B:B:F222 B:B:F253 33.798910.72YesYes586
57B:B:F253 B:B:H225 41.21974.53YesYes569
58R:R:L85 R:R:M137 58.81632.83YesYes099
59R:R:D89 R:R:L85 30.80126.79YesYes099
60R:R:D89 R:R:S304 25.709911.78YesNo099
61R:R:F92 R:R:S304 25.14426.61YesNo079
62R:R:F92 R:R:Y301 23.726116.5YesNo1377
63R:R:M96 R:R:Y301 23.445510.78YesNo1377
64R:R:I133 R:R:L85 10.7715.71NoYes089
65R:R:L134 R:R:L85 17.40632.77NoYes089
66R:R:I133 R:R:T129 10.48663.04NoYes087
67R:R:M96 R:R:P97 16.31533.35YesNo078
68R:R:F98 R:R:P97 15.74552.89NoNo068
69R:R:F265 R:R:L134 15.19264.87YesNo098
70R:R:F265 R:R:W269 10.13034.01YesYes1098
71A:A:L37 A:A:L39 74.27169.69YesYes199
72A:A:W211 B:B:Y145 71.32435.79YesYes198
73A:A:L37 A:A:V201 34.60522.98YesYes199
74A:A:V201 A:A:W211 34.50627.36YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WWH
Class A
SubFamily Peptide
Type Melanin Concentrating Hormone
SubType MCH1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.84
Date 2024-11-13
D.O.I. To be published
Net Summary
Imin 2.69
Number of Linked Nodes 850
Number of Links 1153
Number of Hubs 238
Number of Links mediated by Hubs 817
Number of Communities 23
Number of Nodes involved in Communities 320
Number of Links involved in Communities 516
Path Summary
Number Of Nodes in MetaPath 75
Number Of Links MetaPath 74
Number of Shortest Paths 3872862
Length Of Smallest Path 3
Average Path Length 30.5322
Length of Longest Path 58
Minimum Path Strength 1.265
Average Path Strength 5.92597
Maximum Path Strength 28.58
Minimum Path Correlation 0.7
Average Path Correlation 0.990447
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 39.1099
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.1333
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • signaling receptor binding   • neuropeptide binding   • peptide binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • neuropeptide receptor activity   • melanin-concentrating hormone receptor activity   • protein-hormone receptor activity   • hormone binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell surface receptor signaling pathway
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell surface receptor signaling pathway   • regulation of localization   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • transport   • regulation of transport   • regulation of monoatomic ion transport   • positive regulation of biological process   • establishment of localization   • calcium ion transport   • metal ion transport   • localization   • positive regulation of transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • monoatomic cation transport   • regulation of metal ion transport   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • metabolic process   • generation of precursor metabolites and energy   • behavior   • multicellular organismal process   • feeding behavior   • membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • non-motile cilium   • ciliary membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane
Gene OntologyCellular Component• membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • non-motile cilium   • ciliary membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • neuron projection   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8WWH_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLAEDEEM NRMHSMKLF DSICNNKWF TDTSIILFL 
NKKDLFEEK IKKSPLTIC YPEYAGSNT YEEAAAYIQ CQFEDLNKR 
KDTKEIYTH FTCTDTKNV QFVFDAVTD VIIKNNLKD CGLFNAAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8WWH_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8WWH_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99705
Sequence
>8WWH_Chain_R
YINIIMPSV FGTICLLGI IGNSTVIFA VVKKSKLHW CNNVPDIFI 
INLSVVDLL FLLGMPFMI HQLMGNGVW HFGETMCTL ITAMDANSQ 
FTSTYILTA MAIDRYLAT VHPISSTKF RKPSVATLV ICLLWALSF 
ISITPVWLY ARLIPFPGG AVGCGIRLP NPDTDLYWF TLYQFFLAF 
ALPFVVITA AYVRILQRM TSSVAPASQ RSIRLRTKR VTRTAIAIC 
LVFFVCWAP YYVLQLTQL SISRPTLTF VYLYNAAIS LGYANSCLN 
PFVYIVLCE TFRKRLVLS V


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WSSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensPro-MCH-Gi1/β1/γ13.012024-06-19doi.org/10.1038/s41421-024-00679-8
8WSS (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiensPro-MCH-3.012024-06-19doi.org/10.1038/s41421-024-00679-8
8YNSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensSNAP-94847--3.332024-12-18doi.org/10.1038/s41421-024-00754-0
8YNTAPeptideMelanin Concentrating HormoneMCH1Homo sapiensSNAP-94847--3.432024-12-18doi.org/10.1038/s41421-024-00754-0
8WWKAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.612024-11-13doi.org/10.1038/s41421-024-00754-0
8WWK (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-2.612024-11-13doi.org/10.1038/s41421-024-00754-0
8WWLAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.782024-11-13doi.org/10.1038/s41421-024-00754-0
8WWL (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-2.782024-11-13doi.org/10.1038/s41421-024-00754-0
8WWMAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.812024-11-13doi.org/10.1038/s41421-024-00754-0
8WWM (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-2.812024-11-13doi.org/10.1038/s41421-024-00754-0
8WWNAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.652024-11-13doi.org/10.1038/s41421-024-00754-0
8WWN (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-2.652024-11-13doi.org/10.1038/s41421-024-00754-0
8WWHAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ22.842024-11-13To be published
8WWH (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiens--2.842024-11-13To be published
8WWIAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.432024-11-13To be published
8WWI (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiens--3.432024-11-13To be published
8WWJAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.032024-11-13To be published
8WWJ (No Gprot) APeptideMelanin Concentrating HormoneMCH1Homo sapiens--3.032024-11-13To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WWH.zip



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