psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I42	R:R:Y38	19.34	No	No	0	6	4
2	R:R:I39	R:R:Y291	3.63	No	No	0	3	3
3	R:R:I42	R:R:V46	3.07	No	No	0	6	5
4	R:R:M43	R:R:P44	3.35	No	No	0	5	5
5	R:R:F47	R:R:M43	6.22	Yes	No	0	7	5
6	R:R:M43	R:R:N294	8.41	No	No	0	5	4
7	R:R:M104	R:R:P44	8.39	No	No	0	5	5
8	R:R:S298	R:R:V46	3.23	No	No	0	5	5
9	R:R:F47	R:R:M96	3.73	Yes	Yes	1	7	7
10	R:R:F47	R:R:I100	8.79	Yes	No	1	7	6
11	R:R:F47	R:R:I297	5.02	Yes	No	0	7	5
12	R:R:F47	R:R:S298	5.28	Yes	No	0	7	5
13	R:R:A302	R:R:I50	3.25	No	No	0	5	7
14	R:R:C51	R:R:M96	6.48	No	Yes	0	6	7
15	R:R:C305	R:R:L53	4.76	No	No	0	8	5
16	R:R:F309	R:R:L53	6.09	No	No	0	6	5
17	R:R:C305	R:R:G54	3.92	No	No	0	8	8
18	R:R:I55	R:R:L90	5.71	No	No	0	6	8
19	R:R:I55	R:R:L93	4.28	No	No	0	6	7
20	R:R:G57	R:R:T60	3.64	Yes	No	0	7	5
21	R:R:G57	R:R:P308	4.06	Yes	No	0	7	9
22	R:R:F309	R:R:G57	4.52	No	Yes	0	6	7
23	R:R:N58	R:R:S86	5.96	No	No	0	9	9
24	R:R:D89	R:R:N58	6.73	Yes	No	0	9	9
25	R:R:N58	R:R:P308	14.66	No	No	0	9	9
26	R:R:I312	R:R:T60	3.04	No	No	0	7	5
27	R:R:L322	R:R:T60	4.42	No	No	0	6	5
28	R:R:I82	R:R:V61	4.61	No	No	0	8	9
29	R:R:S86	R:R:V61	8.08	No	No	0	9	9
30	R:R:I62	R:R:I83	5.89	No	No	0	7	6
31	R:R:I62	R:R:S86	3.1	No	No	0	7	9
32	R:R:I62	R:R:V87	3.07	No	No	0	7	6
33	R:R:F63	R:R:K67	4.96	No	No	0	3	5
34	R:R:A64	R:R:F318	4.16	No	No	0	7	8
35	R:R:D79	R:R:V65	5.84	Yes	No	0	8	7
36	R:R:I83	R:R:V65	6.14	No	No	0	6	7
37	R:R:D79	R:R:K68	4.15	Yes	No	0	8	5
38	R:R:C74	R:R:L71	4.76	No	No	0	8	8
39	R:R:T161	R:R:W73	13.34	No	No	0	4	4
40	R:R:D79	R:R:N76	4.04	Yes	No	0	8	8
41	R:R:I80	R:R:N76	4.25	No	No	0	6	8
42	R:R:N76	R:R:P157	3.26	No	No	0	8	1
43	R:R:P78	R:R:V77	3.53	No	Yes	0	8	6
44	R:R:D140	R:R:V77	4.38	No	Yes	5	8	6
45	R:R:R155	R:R:V77	5.23	Yes	Yes	5	6	6
46	R:R:P157	R:R:V77	3.53	No	Yes	0	1	6
47	R:R:D79	R:R:P78	3.22	Yes	No	0	8	8
48	R:R:A160	R:R:I80	3.25	No	No	0	7	6
49	R:R:I80	R:R:T161	3.04	No	No	0	6	4
50	R:R:F81	R:R:M137	3.73	Yes	No	0	7	9
51	R:R:D140	R:R:F81	8.36	No	Yes	0	8	7
52	R:R:F81	R:R:I164	7.54	Yes	No	0	7	7
53	R:R:I82	R:R:M137	4.37	No	No	0	8	9
54	R:R:I82	R:R:Y311	20.55	No	No	0	8	9
55	R:R:I164	R:R:N84	12.74	No	No	0	7	9
56	R:R:D89	R:R:L85	4.07	Yes	No	0	9	9
57	R:R:I133	R:R:L85	7.14	No	No	0	8	9
58	R:R:T129	R:R:V88	7.93	Yes	No	2	7	8
59	R:R:S130	R:R:V88	4.85	No	No	0	9	8
60	R:R:V88	R:R:W168	3.68	No	No	2	8	9
61	R:R:D89	R:R:S130	4.42	Yes	No	0	9	9
62	R:R:D89	R:R:S304	11.78	Yes	No	0	9	9
63	R:R:D89	R:R:N307	6.73	Yes	No	0	9	9
64	R:R:L91	R:R:M122	5.65	No	No	0	6	5
65	R:R:L91	R:R:S126	4.5	No	No	0	6	8
66	R:R:D123	R:R:F92	4.78	No	Yes	1	6	7
67	R:R:F92	R:R:S126	5.28	Yes	No	0	7	8
68	R:R:F92	R:R:Q127	3.51	Yes	No	1	7	8
69	R:R:F92	R:R:W269	4.01	Yes	Yes	1	7	8
70	R:R:F92	R:R:Y301	17.54	Yes	No	1	7	7
71	R:R:F92	R:R:S304	7.93	Yes	No	0	7	9
72	R:R:L93	R:R:S304	3	No	No	0	7	9
73	R:R:M96	R:R:P97	3.35	Yes	No	0	7	8
74	R:R:I100	R:R:M96	5.83	No	Yes	1	6	7
75	R:R:M96	R:R:Y301	15.57	Yes	No	1	7	7
76	R:R:F111	R:R:F98	4.29	No	No	0	6	6
77	R:R:F98	R:R:I119	6.28	No	Yes	0	6	5
78	R:R:D123	R:R:M99	6.93	No	No	0	6	6
79	R:R:I100	R:R:M104	5.83	No	No	0	6	5
80	R:R:H101	R:R:W109	6.35	No	Yes	3	4	8
81	R:R:H101	R:R:H110	7.17	No	No	0	4	2
82	R:R:F111	R:R:H101	4.53	No	No	3	6	4
83	R:R:Q102	R:R:W109	3.29	No	Yes	0	5	8
84	R:R:L103	R:R:N294	5.49	No	No	0	4	4
85	R:R:H110	R:R:V108	6.92	No	No	0	2	5
86	R:R:A191	R:R:V108	5.09	No	No	0	1	5
87	R:R:F111	R:R:W109	11.02	No	Yes	3	6	8
88	R:R:C116	R:R:W109	6.53	No	Yes	3	9	8
89	R:R:I119	R:R:W109	5.87	Yes	Yes	0	5	8
90	R:R:L184	R:R:W109	4.56	No	Yes	3	5	8
91	R:R:C194	R:R:W109	7.84	No	Yes	3	9	8
92	R:R:E113	R:R:R183	8.14	No	No	0	2	4
93	R:R:E113	R:R:L184	5.3	No	No	0	2	5
94	R:R:I119	R:R:M115	4.37	Yes	No	0	5	6
95	R:R:C116	R:R:L184	3.17	No	No	3	9	5
96	R:R:C116	R:R:C194	7.28	No	No	3	9	9
97	R:R:A182	R:R:T117	5.03	No	No	0	4	6
98	R:R:R183	R:R:T117	3.88	No	No	0	4	6
99	R:R:A182	R:R:T120	5.03	No	No	0	4	5
100	R:R:C194	R:R:T120	3.38	No	No	0	9	5
101	R:R:D123	R:R:Y301	8.05	No	No	1	6	7
102	R:R:A124	R:R:V178	5.09	No	No	0	4	5
103	R:R:N125	R:R:T129	5.85	Yes	Yes	2	5	7
104	R:R:N125	R:R:S171	7.45	Yes	No	2	5	8
105	R:R:F172	R:R:N125	7.25	No	Yes	2	4	5
106	R:R:I175	R:R:N125	8.5	No	Yes	2	7	5
107	R:R:Q127	R:R:W269	13.14	No	Yes	1	8	8
108	R:R:Q127	R:R:Y273	4.51	No	Yes	1	8	8
109	R:R:F128	R:R:Y132	8.25	Yes	No	2	6	6
110	R:R:F128	R:R:S174	7.93	Yes	No	2	6	5
111	R:R:F128	R:R:I175	3.77	Yes	No	2	6	7
112	R:R:F128	R:R:Q212	3.51	Yes	No	0	6	5
113	R:R:A216	R:R:F128	5.55	No	Yes	0	5	6
114	R:R:I133	R:R:T129	3.04	No	Yes	0	8	7
115	R:R:T129	R:R:W168	9.7	Yes	No	2	7	9
116	R:R:S171	R:R:T129	6.4	No	Yes	2	8	7
117	R:R:P220	R:R:T131	3.5	No	No	0	9	8
118	R:R:F265	R:R:T131	5.19	No	No	0	9	8
119	R:R:S174	R:R:Y132	5.09	No	No	2	5	6
120	R:R:I224	R:R:L134	4.28	No	No	0	8	8
121	R:R:F265	R:R:L134	4.87	No	No	0	9	8
122	R:R:P220	R:R:T135	3.5	No	No	0	9	7
123	R:R:T135	R:R:V223	3.17	No	No	0	7	6
124	R:R:I224	R:R:T135	7.6	No	No	0	8	7
125	R:R:M137	R:R:R141	6.2	No	No	0	9	9
126	R:R:A138	R:R:Y228	5.34	No	Yes	0	9	9
127	R:R:I139	R:R:V223	3.07	No	No	0	6	6
128	R:R:D140	R:R:R155	13.1	No	Yes	5	8	6
129	R:R:R141	R:R:Y228	8.23	No	Yes	0	9	9
130	R:R:L143	R:R:Y142	3.52	No	No	0	4	8
131	R:R:V146	R:R:Y142	12.62	No	No	0	7	8
132	R:R:R230	R:R:Y142	10.29	No	No	0	4	8
133	R:R:A144	R:R:R155	5.53	No	Yes	0	8	6
134	R:R:H147	R:R:V146	4.15	No	No	0	6	7
135	R:R:R234	R:R:V146	7.85	No	No	0	6	7
136	R:R:H147	R:R:S150	4.18	No	No	0	6	5
137	R:R:R155	R:R:S151	5.27	Yes	No	0	6	6
138	R:R:K156	R:R:S158	3.06	No	No	0	7	4
139	R:R:K156	R:R:V159	6.07	No	No	0	7	4
140	R:R:S171	R:R:S174	3.26	No	No	2	8	5
141	R:R:F172	R:R:I175	3.77	No	No	2	4	7
142	R:R:P177	R:R:T176	3.5	No	No	0	8	4
143	R:R:T176	R:R:W179	3.64	No	No	0	4	4
144	R:R:P177	R:R:W207	5.4	No	No	0	8	5
145	R:R:L180	R:R:W179	7.97	No	No	0	5	4
146	R:R:L180	R:R:Y181	3.52	No	No	0	5	5
147	R:R:L198	R:R:Y181	4.69	No	No	4	5	5
148	R:R:P199	R:R:Y181	11.13	Yes	No	4	4	5
149	R:R:I185	R:R:P186	3.39	No	No	0	2	2
150	R:R:F187	R:R:I185	7.54	No	No	0	1	2
151	R:R:G195	R:R:I185	3.53	No	No	0	3	2
152	R:R:P186	R:R:R197	5.76	No	No	0	2	3
153	R:R:F187	R:R:P188	4.33	No	No	0	1	3
154	R:R:F187	R:R:G193	3.01	No	No	0	1	5
155	R:R:L198	R:R:P199	3.28	No	Yes	4	5	4
156	R:R:N200	R:R:P199	4.89	No	Yes	4	4	4
157	R:R:D204	R:R:P199	6.44	Yes	Yes	4	2	4
158	R:R:D204	R:R:N200	13.46	Yes	No	4	2	4
159	R:R:D204	R:R:T203	4.34	Yes	No	0	2	3
160	R:R:D204	R:R:W207	7.82	Yes	No	0	2	5
161	R:R:L205	R:R:L280	4.15	No	No	0	5	5
162	R:R:L280	R:R:Y206	3.52	No	No	0	5	3
163	R:R:F208	R:R:Q212	12.88	No	No	0	5	5
164	R:R:Q276	R:R:T209	4.25	Yes	No	0	5	5
165	R:R:Q212	R:R:Y211	6.76	No	No	0	5	3
166	R:R:L215	R:R:Y211	3.52	No	No	0	4	3
167	R:R:F213	R:R:F217	7.5	No	Yes	1	5	8
168	R:R:A218	R:R:F213	4.16	No	No	0	5	5
169	R:R:F213	R:R:Y273	7.22	No	Yes	1	5	8
170	R:R:F214	R:R:L215	3.65	No	No	0	4	4
171	R:R:F214	R:R:L219	4.87	No	No	0	4	5
172	R:R:F217	R:R:F266	5.36	Yes	No	1	8	6
173	R:R:A270	R:R:F217	4.16	No	Yes	1	5	8
174	R:R:F217	R:R:Y273	8.25	Yes	Yes	1	8	8
175	R:R:L219	R:R:P220	3.28	No	No	0	5	9
176	R:R:F221	R:R:T225	7.78	No	No	0	6	5
177	R:R:F221	R:R:F265	7.5	No	No	0	6	9
178	R:R:F221	R:R:F266	15	No	No	0	6	6
179	R:R:C262	R:R:T225	5.07	No	No	0	8	5
180	R:R:A258	R:R:Y228	4	No	Yes	0	8	9
181	R:R:I261	R:R:Y228	14.51	No	Yes	0	8	9
182	R:R:C262	R:R:Y228	4.03	No	Yes	0	8	9
183	R:R:R230	R:R:R234	4.26	No	No	0	4	6
184	R:R:L232	R:R:V254	2.98	No	No	0	5	7
185	R:R:L232	R:R:T255	8.84	No	No	0	5	6
186	R:R:A258	R:R:L232	4.73	No	No	0	8	5
187	R:R:M235	R:R:T236	3.01	Yes	No	6	8	4
188	R:R:M235	R:R:R250	3.72	Yes	No	6	8	6
189	R:R:M235	R:R:T251	9.03	Yes	No	0	8	7
190	R:R:M235	R:R:V254	9.13	Yes	No	0	8	7
191	R:R:R250	R:R:T236	5.17	No	No	6	6	4
192	R:R:S238	R:R:V239	3.23	No	No	0	6	3
193	R:R:P241	R:R:Q244	7.9	No	No	0	3	4
194	R:R:I247	R:R:P241	3.39	Yes	No	0	4	3
195	R:R:Q244	R:R:S246	11.55	No	No	0	4	4
196	R:R:I247	R:R:S246	3.1	Yes	No	0	4	4
197	R:R:I247	R:R:R250	5.01	Yes	No	0	4	6
198	R:R:R253	R:R:R256	3.2	No	No	0	7	7
199	R:R:E316	R:R:R253	5.82	No	No	0	5	7
200	R:R:I261	R:R:T257	3.04	No	No	0	8	8
201	R:R:L314	R:R:T257	13.27	Yes	No	0	7	8
202	R:R:I261	R:R:V310	3.07	No	No	0	8	8
203	R:R:L263	R:R:V267	2.98	No	No	0	5	6
204	R:R:L306	R:R:V264	4.47	No	No	0	6	6
205	R:R:A270	R:R:F266	8.32	No	No	1	5	6
206	R:R:C268	R:R:N303	4.72	No	No	0	8	9
207	R:R:W269	R:R:Y272	4.82	Yes	Yes	1	8	7
208	R:R:G300	R:R:W269	8.44	No	Yes	0	7	8
209	R:R:N303	R:R:W269	13.56	No	Yes	0	9	8
210	R:R:L299	R:R:P271	3.28	No	No	0	8	9
211	R:R:Y272	R:R:Y273	6.95	Yes	Yes	1	7	8
212	R:R:Q276	R:R:Y272	12.4	Yes	Yes	1	5	7
213	R:R:Y272	R:R:Y293	2.98	Yes	No	1	7	3
214	R:R:F289	R:R:L275	6.09	Yes	No	0	4	4
215	R:R:Q276	R:R:Q279	6.4	Yes	No	0	5	3
216	R:R:Q276	R:R:Y293	9.02	Yes	No	1	5	3
217	R:R:I282	R:R:T278	4.56	No	No	0	3	4
218	R:R:F289	R:R:I282	6.28	Yes	No	0	4	3
219	R:R:T286	R:R:T288	6.28	No	No	0	1	3
220	R:R:I297	R:R:Y293	4.84	No	No	0	5	3
221	R:R:L299	R:R:S298	3	No	No	0	8	5
222	R:R:N303	R:R:N307	12.26	No	No	0	9	9
223	R:R:F318	R:R:Y311	12.38	No	No	0	8	9
224	R:R:E316	R:R:R319	11.63	No	No	0	5	8
225	R:R:L324	R:R:R321	9.72	No	No	0	4	5
226	R:R:N294	R:R:V290	2.96	No	No	0	4	3
227	R:R:L277	R:R:T209	2.95	No	No	0	6	5
228	R:R:I119	R:R:M99	2.92	Yes	No	0	5	6
229	R:R:W207	R:R:Y211	2.89	No	No	0	5	3
230	R:R:I139	R:R:L143	2.85	No	No	0	6	4
231	R:R:I196	R:R:L198	2.85	No	No	0	4	5
232	R:R:I39	R:R:N40	2.83	No	No	0	3	4
233	R:R:L118	R:R:M115	2.83	No	No	0	4	6
234	R:R:G112	R:R:W109	2.81	No	Yes	0	7	8
235	R:R:C315	R:R:F318	2.79	No	No	0	8	8
236	R:R:A136	R:R:F81	2.77	No	Yes	0	7	7
237	R:R:L90	R:R:L94	2.77	No	No	0	8	5
238	R:R:A242	R:R:R248	2.77	No	No	0	4	4
239	R:R:A296	R:R:Y272	2.67	No	Yes	0	6	7
240	R:R:F154	R:R:S151	2.64	No	No	0	4	6
241	R:R:A121	R:R:W179	2.59	No	No	0	5	4
242	R:R:L314	R:R:R256	2.43	Yes	No	0	7	7
243	R:R:G189	R:R:G190	2.11	No	No	0	3	4
244	R:R:G95	R:R:P97	2.03	No	No	0	6	8
245	R:R:C51	R:R:G48	1.96	No	No	0	6	3
246	R:R:A240	R:R:P241	1.87	No	No	0	4	3
247	R:R:G107	R:R:V108	1.84	No	No	0	4	5
248	R:R:G193	R:R:V192	1.84	No	No	0	5	4
249	R:R:A302	R:R:C268	1.81	No	No	0	5	8
250	R:R:A138	R:R:A227	1.79	No	No	0	9	7
251	R:R:G57	R:R:I56	1.76	Yes	No	0	7	4
252	R:R:G105	R:R:M104	1.75	No	No	0	4	5
253	R:R:A240	R:R:S237	1.71	No	No	0	4	4
254	R:R:C268	R:R:V264	1.71	No	No	0	8	6
255	R:R:G105	R:R:N106	1.7	No	No	0	4	4
256	R:R:C165	R:R:T161	1.69	No	No	0	4	4
257	R:R:C315	R:R:T317	1.69	No	No	0	8	6
258	R:R:K156	R:R:P157	1.67	No	No	0	7	1
259	R:R:G193	R:R:Q102	1.64	No	No	0	5	5
260	R:R:N200	R:R:P201	1.63	No	No	0	4	3
261	R:R:S237	R:R:S238	1.63	No	No	0	4	6
262	R:R:S45	R:R:V46	1.62	No	No	0	4	5
263	R:R:A242	R:R:I247	1.62	No	Yes	0	4	4
264	R:R:V159	R:R:V163	1.6	No	No	0	4	6
265	R:R:S281	R:R:T278	1.6	No	No	0	4	4
266	R:R:T120	R:R:V178	1.59	No	No	0	5	5
267	R:R:T225	R:R:V229	1.59	No	No	0	5	4
268	R:R:T278	R:R:V274	1.59	No	No	0	4	6
269	R:R:A136	R:R:L167	1.58	No	No	0	7	7
270	R:R:A260	R:R:L314	1.58	No	Yes	0	6	7
271	R:R:A296	R:R:L275	1.58	No	No	0	6	4
272	R:R:C74	R:R:N75	1.57	No	No	0	8	4
273	R:R:I55	R:R:S59	1.55	No	No	0	6	3
274	R:R:I83	R:R:V66	1.54	No	No	0	6	3
275	R:R:I231	R:R:V254	1.54	No	No	0	8	7
276	R:R:H147	R:R:P148	1.53	No	No	0	6	8
277	R:R:I231	R:R:T145	1.52	No	No	0	8	9
278	R:R:I259	R:R:T255	1.52	No	No	0	5	6
279	R:R:M115	R:R:T114	1.51	No	No	0	6	3
280	R:R:L314	R:R:V313	1.49	Yes	No	0	7	7
281	R:R:L280	R:R:T209	1.47	No	No	0	5	5
282	R:R:L287	R:R:T286	1.47	No	No	0	2	1
283	R:R:D202	R:R:T203	1.45	No	No	0	2	3
284	R:R:P285	R:R:R284	1.44	No	No	0	1	2
285	R:R:F289	R:R:P285	1.44	Yes	No	0	4	1
286	R:R:H72	R:R:S69	1.39	No	No	0	7	6
287	R:R:L210	R:R:L277	1.38	No	No	0	4	6
288	R:R:L275	R:R:L292	1.38	No	No	0	4	5
289	R:R:R284	R:R:S283	1.32	No	No	0	2	1
290	R:R:F289	R:R:T286	1.3	Yes	No	0	4	1
291	R:R:F154	R:R:K153	1.24	No	No	0	4	3
292	R:R:L249	R:R:R253	1.21	No	No	0	4	7
293	R:R:Q233	R:R:R230	1.17	No	No	0	3	4
294	R:R:L287	R:R:Y291	1.17	No	No	0	2	3
295	R:R:H72	R:R:W73	1.06	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F47	5.808	5	1	7
2	R:R:G57	3.495	4	0	7
3	R:R:V77	4.1675	4	5	6
4	R:R:D79	4.3125	4	0	8
5	R:R:F81	5.6	4	0	7
6	R:R:D89	6.746	5	0	9
7	R:R:F92	7.175	6	1	7
8	R:R:M96	6.992	5	1	7
9	R:R:W109	6.03375	8	3	8
10	R:R:I119	4.86	4	0	5
11	R:R:N125	7.2625	4	2	5
12	R:R:F128	5.802	5	2	6
13	R:R:T129	6.584	5	2	7
14	R:R:R155	7.2825	4	5	6
15	R:R:P199	6.435	4	4	4
16	R:R:D204	8.015	4	4	2
17	R:R:F217	6.3175	4	1	8
18	R:R:Y228	7.222	5	0	9
19	R:R:M235	6.2225	4	6	8
20	R:R:I247	3.28	4	0	4
21	R:R:W269	8.794	5	1	8
22	R:R:Y272	5.964	5	1	7
23	R:R:Y273	6.7325	4	1	8
24	R:R:Q276	8.0175	4	1	5
25	R:R:F289	3.7775	4	0	4
26	R:R:L314	4.6925	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L287	R:R:T286	10.1391	1.47	No	No	0	2	1
2	R:R:F289	R:R:T286	15.1894	1.3	Yes	No	0	4	1
3	R:R:F289	R:R:L275	34.7882	6.09	Yes	No	0	4	4
4	R:R:A296	R:R:L275	39.5949	1.58	No	No	0	6	4
5	R:R:A296	R:R:Y272	41.9919	2.67	No	Yes	0	6	7
6	R:R:Y272	R:R:Y293	16.3751	2.98	Yes	No	1	7	3
7	R:R:I297	R:R:Y293	15.4201	4.84	No	No	0	5	3
8	R:R:F47	R:R:I297	14.2537	5.02	Yes	No	0	7	5
9	R:R:F47	R:R:S298	15.6957	5.28	Yes	No	0	7	5
10	R:R:F47	R:R:M43	11.0748	6.22	Yes	No	0	7	5
11	R:R:F47	R:R:M96	20.2269	3.73	Yes	Yes	1	7	7
12	R:R:C268	R:R:N303	15.3432	4.72	No	No	0	8	9
13	R:R:N303	R:R:W269	29.834	13.56	No	Yes	0	9	8
14	R:R:F92	R:R:W269	30.853	4.01	Yes	Yes	1	7	8
15	R:R:F92	R:R:Y301	34.4293	17.54	Yes	No	1	7	7
16	R:R:M96	R:R:Y301	38.2426	15.57	Yes	No	1	7	7
17	R:R:W269	R:R:Y272	47.8177	4.82	Yes	Yes	1	8	7
18	R:R:G57	R:R:P308	21.7458	4.06	Yes	No	0	7	9
19	R:R:N58	R:R:P308	24.1107	14.66	No	No	0	9	9
20	R:R:D89	R:R:N58	91.1043	6.73	Yes	No	0	9	9
21	R:R:D89	R:R:S304	100	11.78	Yes	No	0	9	9
22	R:R:F92	R:R:S304	97.5005	7.93	Yes	No	0	7	9
23	R:R:L93	R:R:S304	11.4017	3	No	No	0	7	9
24	R:R:N58	R:R:S86	76.3122	5.96	No	No	0	9	9
25	R:R:S86	R:R:V61	41.6715	8.08	No	No	0	9	9
26	R:R:I82	R:R:V61	40.5243	4.61	No	No	0	8	9
27	R:R:I62	R:R:S86	39.4219	3.1	No	No	0	7	9
28	R:R:I62	R:R:I83	35.192	5.89	No	No	0	7	6
29	R:R:I82	R:R:Y311	11.9336	20.55	No	No	0	8	9
30	R:R:D79	R:R:V65	29.3726	5.84	Yes	No	0	8	7
31	R:R:I83	R:R:V65	30.9876	6.14	No	No	0	6	7
32	R:R:D79	R:R:N76	22.3675	4.04	Yes	No	0	8	8
33	R:R:I80	R:R:N76	16.8173	4.25	No	No	0	6	8
34	R:R:I80	R:R:T161	12.0746	3.04	No	No	0	6	4
35	R:R:N76	R:R:P157	13.6512	3.26	No	No	0	8	1
36	R:R:I82	R:R:M137	34.5575	4.37	No	No	0	8	9
37	R:R:F81	R:R:M137	34.6792	3.73	Yes	No	0	7	9
38	R:R:D140	R:R:F81	25.0913	8.36	No	Yes	0	8	7
39	R:R:D140	R:R:V77	12.6835	4.38	No	Yes	5	8	6
40	R:R:D140	R:R:R155	10.4723	13.1	No	Yes	5	8	6
41	R:R:D89	R:R:L85	52.6053	4.07	Yes	No	0	9	9
42	R:R:I133	R:R:L85	51.4004	7.14	No	No	0	8	9
43	R:R:I133	R:R:T129	50.3942	3.04	No	Yes	0	8	7
44	R:R:D89	R:R:S130	54.1627	4.42	Yes	No	0	9	9
45	R:R:S130	R:R:V88	52.9578	4.85	No	No	0	9	8
46	R:R:T129	R:R:V88	50.3813	7.93	Yes	No	2	7	8
47	R:R:N303	R:R:N307	27.296	12.26	No	No	0	9	9
48	R:R:D89	R:R:N307	27.7831	6.73	Yes	No	0	9	9
49	R:R:F92	R:R:Q127	34.0063	3.51	Yes	No	1	7	8
50	R:R:I119	R:R:M99	69.0701	2.92	Yes	No	0	5	6
51	R:R:D123	R:R:M99	70.8453	6.93	No	No	0	6	6
52	R:R:I119	R:R:W109	57.7645	5.87	Yes	Yes	0	5	8
53	R:R:H101	R:R:W109	10.9787	6.35	No	Yes	3	4	8
54	R:R:Q102	R:R:W109	19.7782	3.29	No	Yes	0	5	8
55	R:R:C194	R:R:W109	13.036	7.84	No	Yes	3	9	8
56	R:R:C194	R:R:T120	10.9338	3.38	No	No	0	9	5
57	R:R:N125	R:R:T129	49.3751	5.85	Yes	Yes	2	5	7
58	R:R:S171	R:R:T129	49.3495	6.4	No	Yes	2	8	7
59	R:R:I175	R:R:N125	43.4724	8.5	No	Yes	2	7	5
60	R:R:Y272	R:R:Y273	33.0642	6.95	Yes	Yes	1	7	8
61	R:R:F128	R:R:S174	40.6973	7.93	Yes	No	2	6	5
62	R:R:S171	R:R:S174	46.5487	3.26	No	No	2	8	5
63	R:R:F128	R:R:I175	41.0178	3.77	Yes	No	2	6	7
64	R:R:F128	R:R:Q212	72.8642	3.51	Yes	No	0	6	5
65	R:R:F217	R:R:Y273	67.5768	8.25	Yes	Yes	1	8	8
66	R:R:F217	R:R:F266	67.7818	5.36	Yes	No	1	8	6
67	R:R:F221	R:R:F266	68.4804	15	No	No	0	6	6
68	R:R:F221	R:R:F265	60.0718	7.5	No	No	0	6	9
69	R:R:F265	R:R:T131	37.621	5.19	No	No	0	9	8
70	R:R:P220	R:R:T131	36.493	3.5	No	No	0	9	8
71	R:R:I224	R:R:L134	20.432	4.28	No	No	0	8	8
72	R:R:F265	R:R:L134	21.8227	4.87	No	No	0	9	8
73	R:R:P220	R:R:T135	22.7969	3.5	No	No	0	9	7
74	R:R:I224	R:R:T135	19.304	7.6	No	No	0	8	7
75	R:R:T135	R:R:V223	38.0696	3.17	No	No	0	7	6
76	R:R:M137	R:R:R141	37.1595	6.2	No	No	0	9	9
77	R:R:F221	R:R:T225	59.6039	7.78	No	No	0	6	5
78	R:R:C262	R:R:T225	58.2196	5.07	No	No	0	8	5
79	R:R:C262	R:R:Y228	57.694	4.03	No	Yes	0	8	9
80	R:R:R141	R:R:Y228	37.0442	8.23	No	Yes	0	9	9
81	R:R:I139	R:R:V223	34.9548	3.07	No	No	0	6	6
82	R:R:I139	R:R:L143	31.8272	2.85	No	No	0	6	4
83	R:R:L143	R:R:Y142	28.6868	3.52	No	No	0	4	8
84	R:R:V146	R:R:Y142	15.9521	12.62	No	No	0	7	8
85	R:R:K156	R:R:P157	10.0173	1.67	No	No	0	7	1
86	R:R:Q212	R:R:Y211	63.7121	6.76	No	No	0	5	3
87	R:R:W207	R:R:Y211	64.6606	2.89	No	No	0	5	3
88	R:R:P177	R:R:W207	20.3422	5.4	No	No	0	8	5
89	R:R:P177	R:R:T176	16.3046	3.5	No	No	0	8	4
90	R:R:T176	R:R:W179	12.2541	3.64	No	No	0	4	4
91	R:R:D204	R:R:W207	40.6332	7.82	Yes	No	0	2	5
92	R:R:D204	R:R:P199	20.4127	6.44	Yes	Yes	4	2	4
93	R:R:F187	R:R:G193	13.2987	3.01	No	No	0	1	5
94	R:R:G193	R:R:Q102	17.6312	1.64	No	No	0	5	5
95	R:R:Q276	R:R:T209	15.1061	4.25	Yes	No	0	5	5
96	R:R:L219	R:R:P220	20.4832	3.28	No	No	0	5	9
97	R:R:F214	R:R:L219	19.5091	4.87	No	No	0	4	5
98	R:R:F214	R:R:L215	18.9899	3.65	No	No	0	4	4
99	R:R:A258	R:R:Y228	39.3322	4	No	Yes	0	8	9
100	R:R:I261	R:R:Y228	20.5089	14.51	No	Yes	0	8	9
101	R:R:A258	R:R:L232	37.653	4.73	No	No	0	8	5
102	R:R:L232	R:R:V254	32.5835	2.98	No	No	0	5	7
103	R:R:M235	R:R:V254	27.5588	9.13	Yes	No	0	8	7
104	R:R:M235	R:R:R250	22.2073	3.72	Yes	No	6	8	6
105	R:R:I247	R:R:R250	20.5089	5.01	Yes	No	0	4	6
106	R:R:I247	R:R:P241	11.3312	3.39	Yes	No	0	4	3
107	R:R:I261	R:R:T257	16.8942	3.04	No	No	0	8	8
108	R:R:L314	R:R:T257	15.0676	13.27	Yes	No	0	7	8
109	R:R:F289	R:R:I282	10.2352	6.28	Yes	No	0	4	3
110	R:R:D123	R:R:F92	66.923	4.78	No	Yes	1	6	7
111	R:R:Q127	R:R:Y273	37.6979	4.51	No	Yes	1	8	8
112	R:R:L215	R:R:Y211	20.3102	3.52	No	No	0	4	3
113	R:R:Q276	R:R:Y272	18.8105	12.4	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8WWI_nogp

PDB Summary
PDB	8WWI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	268
Number of Links	295
Number of Hubs	26
Number of Links mediated by Hubs	108
Number of Communities	6
Number of Nodes involved in Communities	43
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	114
Number Of Links MetaPath	113
Number of Shortest Paths	52319
Length Of Smallest Path	3
Average Path Length	14.5461
Length of Longest Path	30
Minimum Path Strength	1.225
Average Path Strength	5.9794
Maximum Path Strength	16.555
Minimum Path Correlation	0.7
Average Path Correlation	0.930418
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.4425
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.0109
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99705
Sequence	>8WWI_nogp_Chain_R Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S K L H W C N N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G N G V W H F G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H P I S S T K F R K P S V A T L V I C L L W A L S F I S I T P V W L Y A R L I P F P G G A V G C G I R L P N P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M T S S V A P A S Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I S R P T L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T F R K R L V L S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	To be published
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	To be published
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	To be published
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	To be published
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	To be published
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	To be published
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	To be published
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	10.1038/s41421-024-00679-8
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	10.1038/s41421-024-00754-0
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	10.1038/s41421-024-00754-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WWI_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.