psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D1	R:R:N40	5.39	No	No	0	0	4
2	L:L:F2	L:L:M4	4.98	No	No	0	0	0
3	L:L:F2	L:L:R6	12.83	No	No	0	0	0
4	L:L:F2	R:R:G107	4.52	No	No	0	0	4
5	L:L:D3	L:L:L5	12.21	No	No	0	0	0
6	L:L:M4	R:R:Y291	4.79	No	No	0	0	3
7	L:L:R6	L:L:Y13	11.32	No	Yes	3	0	0
8	L:L:R6	R:R:F187	23.52	No	Yes	3	0	1
9	L:L:C7	L:L:R14	12.54	No	No	0	0	0
10	L:L:C16	L:L:C7	7.28	No	No	0	0	0
11	L:L:C7	R:R:P285	3.77	No	No	0	0	1
12	L:L:M8	L:L:Y13	7.18	No	Yes	0	0	0
13	L:L:M8	R:R:Y293	11.97	No	Yes	0	0	3
14	L:L:L9	L:L:R14	4.86	No	No	0	0	0
15	L:L:L9	R:R:L205	4.15	No	No	0	0	5
16	L:L:L9	R:R:F208	7.31	No	Yes	0	0	5
17	L:L:R11	R:R:F92	6.41	Yes	Yes	1	0	7
18	L:L:R11	R:R:D123	5.96	Yes	Yes	1	0	6
19	L:L:R11	R:R:Q127	15.19	Yes	Yes	1	0	8
20	L:L:R11	R:R:Y272	11.32	Yes	Yes	1	0	7
21	L:L:R11	R:R:I297	5.01	Yes	No	0	0	5
22	L:L:R11	R:R:Y301	4.12	Yes	Yes	1	0	7
23	L:L:V12	R:R:G195	3.68	No	No	0	0	3
24	L:L:V12	R:R:I196	3.07	No	No	0	0	4
25	L:L:Y13	R:R:Q102	10.15	Yes	No	0	0	5
26	L:L:Y13	R:R:L103	7.03	Yes	No	0	0	4
27	L:L:Y13	R:R:F187	12.38	Yes	Yes	3	0	1
28	L:L:P15	R:R:I185	3.39	No	No	0	0	2
29	L:L:P15	R:R:R197	4.32	No	No	0	0	3
30	L:L:W17	R:R:P201	4.05	No	No	0	0	3
31	L:L:W17	R:R:D202	21.22	No	No	0	0	2
32	R:R:I39	R:R:N40	7.08	No	No	0	3	4
33	R:R:I39	R:R:Y291	4.84	No	No	0	3	3
34	R:R:I42	R:R:S45	4.64	No	No	0	6	4
35	R:R:M43	R:R:P44	3.35	No	No	0	5	5
36	R:R:F47	R:R:M43	6.22	Yes	No	0	7	5
37	R:R:M43	R:R:N294	8.41	No	No	0	5	4
38	R:R:M104	R:R:P44	3.35	No	No	0	5	5
39	R:R:I50	R:R:V46	3.07	No	No	0	7	5
40	R:R:S298	R:R:V46	3.23	No	No	0	5	5
41	R:R:F47	R:R:M96	4.98	Yes	Yes	1	7	7
42	R:R:F47	R:R:I100	11.3	Yes	Yes	1	7	6
43	R:R:C305	R:R:I50	3.27	Yes	No	0	8	7
44	R:R:C51	R:R:M96	3.24	No	Yes	0	6	7
45	R:R:C305	R:R:L53	4.76	Yes	No	0	8	5
46	R:R:F309	R:R:L53	4.87	No	No	0	6	5
47	R:R:C305	R:R:G54	3.92	Yes	No	0	8	8
48	R:R:F309	R:R:G57	4.52	No	No	0	6	7
49	R:R:N58	R:R:S86	2.98	No	No	0	9	9
50	R:R:D89	R:R:N58	5.39	Yes	No	0	9	9
51	R:R:N58	R:R:P308	16.29	No	No	0	9	9
52	R:R:I312	R:R:T60	3.04	No	No	0	7	5
53	R:R:S86	R:R:V61	3.23	No	No	0	9	9
54	R:R:I312	R:R:V61	3.07	No	No	4	7	9
55	R:R:F318	R:R:V61	5.24	Yes	No	4	8	9
56	R:R:I62	R:R:S86	3.1	No	No	0	7	9
57	R:R:F63	R:R:K67	13.65	No	No	0	3	5
58	R:R:A64	R:R:F318	4.16	No	Yes	0	7	8
59	R:R:A64	R:R:L322	3.15	No	No	0	7	6
60	R:R:R321	R:R:V65	3.92	No	No	0	5	7
61	R:R:K67	R:R:S325	3.06	No	No	0	5	7
62	R:R:C74	R:R:K68	3.23	No	No	0	8	5
63	R:R:K68	R:R:R321	18.56	No	No	0	5	5
64	R:R:C74	R:R:S69	5.16	No	No	0	8	6
65	R:R:N76	R:R:P78	8.15	No	No	0	8	8
66	R:R:D79	R:R:N76	12.12	No	No	0	8	8
67	R:R:P78	R:R:V77	3.53	No	No	0	8	6
68	R:R:P157	R:R:V77	5.3	No	No	0	1	6
69	R:R:A160	R:R:V77	3.39	No	No	0	7	6
70	R:R:D79	R:R:R321	8.34	No	No	0	8	5
71	R:R:I80	R:R:N84	4.25	No	No	0	6	9
72	R:R:F81	R:R:M137	7.46	No	No	0	7	9
73	R:R:D140	R:R:F81	4.78	No	No	0	8	7
74	R:R:F81	R:R:I164	7.54	No	No	0	7	7
75	R:R:I82	R:R:Y311	15.71	No	No	0	8	9
76	R:R:I164	R:R:N84	9.91	No	No	0	7	9
77	R:R:D89	R:R:L85	9.5	Yes	No	0	9	9
78	R:R:I133	R:R:L85	5.71	No	No	0	8	9
79	R:R:T129	R:R:V88	7.93	Yes	Yes	1	7	8
80	R:R:S130	R:R:V88	3.23	No	Yes	0	9	8
81	R:R:I133	R:R:V88	3.07	No	Yes	1	8	8
82	R:R:V88	R:R:W168	3.68	Yes	No	1	8	9
83	R:R:D89	R:R:S304	11.78	Yes	No	0	9	9
84	R:R:D89	R:R:N307	8.08	Yes	No	0	9	9
85	R:R:L90	R:R:L94	4.15	No	No	0	8	5
86	R:R:L91	R:R:M122	4.24	No	No	1	6	5
87	R:R:L91	R:R:S126	3	No	No	1	6	8
88	R:R:D123	R:R:F92	4.78	Yes	Yes	1	6	7
89	R:R:F92	R:R:S126	3.96	Yes	No	1	7	8
90	R:R:F92	R:R:Q127	4.68	Yes	Yes	1	7	8
91	R:R:F92	R:R:Y301	11.35	Yes	Yes	1	7	7
92	R:R:F92	R:R:S304	6.61	Yes	No	0	7	9
93	R:R:M96	R:R:P97	3.35	Yes	No	0	7	8
94	R:R:I100	R:R:M96	5.83	Yes	Yes	1	6	7
95	R:R:M96	R:R:Y301	17.96	Yes	Yes	1	7	7
96	R:R:F111	R:R:F98	7.5	Yes	No	2	6	6
97	R:R:F98	R:R:I119	5.02	No	Yes	2	6	5
98	R:R:M99	R:R:T120	6.02	No	No	0	6	5
99	R:R:D123	R:R:M99	13.86	Yes	No	0	6	6
100	R:R:I100	R:R:M104	4.37	Yes	No	0	6	5
101	R:R:I100	R:R:Y301	3.63	Yes	Yes	1	6	7
102	R:R:H101	R:R:W109	9.52	No	Yes	2	4	8
103	R:R:F111	R:R:H101	10.18	Yes	No	2	6	4
104	R:R:Q102	R:R:W109	7.67	No	Yes	0	5	8
105	R:R:G105	R:R:N106	5.09	No	No	0	4	4
106	R:R:H110	R:R:V108	8.3	No	No	0	2	5
107	R:R:F111	R:R:W109	13.03	Yes	Yes	2	6	8
108	R:R:C116	R:R:W109	3.92	No	Yes	2	9	8
109	R:R:I119	R:R:W109	3.52	Yes	Yes	2	5	8
110	R:R:L184	R:R:W109	3.42	No	Yes	2	5	8
111	R:R:C194	R:R:W109	13.06	No	Yes	2	9	8
112	R:R:F111	R:R:I119	3.77	Yes	Yes	2	6	5
113	R:R:E113	R:R:L184	3.98	No	No	0	2	5
114	R:R:I119	R:R:M115	5.83	Yes	No	0	5	6
115	R:R:C116	R:R:L184	3.17	No	No	2	9	5
116	R:R:C116	R:R:C194	7.28	No	No	2	9	9
117	R:R:A182	R:R:T117	5.03	No	No	0	4	6
118	R:R:T120	R:R:V178	3.17	No	No	0	5	5
119	R:R:M122	R:R:S126	4.6	No	No	1	5	8
120	R:R:D123	R:R:Y301	3.45	Yes	Yes	1	6	7
121	R:R:A124	R:R:V178	3.39	No	No	0	4	5
122	R:R:N125	R:R:T129	7.31	Yes	Yes	1	5	7
123	R:R:N125	R:R:W168	4.52	Yes	No	1	5	9
124	R:R:N125	R:R:S171	10.43	Yes	No	1	5	8
125	R:R:F172	R:R:N125	6.04	No	Yes	0	4	5
126	R:R:I175	R:R:N125	4.25	No	Yes	0	7	5
127	R:R:F128	R:R:Q127	3.51	Yes	Yes	1	6	8
128	R:R:Q127	R:R:W269	7.67	Yes	Yes	1	8	8
129	R:R:Q127	R:R:Y273	5.64	Yes	Yes	1	8	8
130	R:R:F128	R:R:Y132	9.28	Yes	No	1	6	6
131	R:R:F128	R:R:S174	7.93	Yes	No	1	6	5
132	R:R:F128	R:R:I175	3.77	Yes	No	0	6	7
133	R:R:F128	R:R:Q212	3.51	Yes	No	1	6	5
134	R:R:A216	R:R:F128	6.93	No	Yes	0	5	6
135	R:R:I133	R:R:T129	3.04	No	Yes	1	8	7
136	R:R:T129	R:R:W168	12.13	Yes	No	1	7	9
137	R:R:S171	R:R:T129	3.2	No	Yes	1	8	7
138	R:R:P220	R:R:T131	3.5	Yes	No	1	9	8
139	R:R:F265	R:R:T131	7.78	Yes	No	1	9	8
140	R:R:S174	R:R:Y132	5.09	No	No	1	5	6
141	R:R:L215	R:R:Y132	3.52	No	No	0	4	6
142	R:R:I224	R:R:L134	4.28	No	No	0	8	8
143	R:R:F265	R:R:L134	4.87	Yes	No	0	9	8
144	R:R:P220	R:R:T135	3.5	Yes	No	0	9	7
145	R:R:T135	R:R:V223	3.17	No	No	0	7	6
146	R:R:I224	R:R:T135	7.6	No	No	0	8	7
147	R:R:A136	R:R:L167	3.15	No	No	0	7	7
148	R:R:M137	R:R:R141	9.93	No	No	0	9	9
149	R:R:A138	R:R:I224	4.87	No	No	0	9	8
150	R:R:A138	R:R:Y228	5.34	No	Yes	0	9	9
151	R:R:I139	R:R:V223	3.07	No	No	0	6	6
152	R:R:D140	R:R:R155	9.53	No	Yes	0	8	6
153	R:R:R141	R:R:Y228	9.26	No	Yes	0	9	9
154	R:R:V146	R:R:Y142	13.88	No	No	5	7	8
155	R:R:H147	R:R:Y142	6.53	Yes	No	5	6	8
156	R:R:L143	R:R:R155	6.07	No	Yes	0	4	6
157	R:R:A144	R:R:R155	6.91	No	Yes	0	8	6
158	R:R:I231	R:R:T145	9.12	No	No	0	8	9
159	R:R:H147	R:R:V146	5.54	Yes	No	5	6	7
160	R:R:R234	R:R:V146	6.54	No	No	0	6	7
161	R:R:H147	R:R:S150	4.18	Yes	No	0	6	5
162	R:R:R155	R:R:S151	3.95	Yes	No	0	6	6
163	R:R:K156	R:R:S158	3.06	No	No	0	7	4
164	R:R:L167	R:R:V163	4.47	No	No	0	7	6
165	R:R:L166	R:R:L170	4.15	No	No	0	4	4
166	R:R:S171	R:R:S174	3.26	No	No	1	8	5
167	R:R:I175	R:R:V178	3.07	No	No	0	7	5
168	R:R:P177	R:R:T176	5.25	No	No	0	8	4
169	R:R:T176	R:R:W179	3.64	No	Yes	0	4	4
170	R:R:P177	R:R:W207	5.4	No	No	0	8	5
171	R:R:P177	R:R:Y211	6.95	No	Yes	0	8	3
172	R:R:L180	R:R:W179	10.25	No	Yes	0	5	4
173	R:R:L180	R:R:Y181	3.52	No	No	0	5	5
174	R:R:L198	R:R:Y181	4.69	No	No	0	5	5
175	R:R:P199	R:R:Y181	5.56	No	No	0	4	5
176	R:R:R183	R:R:R197	4.26	No	No	0	4	3
177	R:R:I185	R:R:P186	3.39	No	No	0	2	2
178	R:R:G195	R:R:I185	3.53	No	No	0	3	2
179	R:R:F187	R:R:P188	4.33	Yes	No	0	1	3
180	R:R:F187	R:R:G193	4.52	Yes	No	0	1	5
181	R:R:D204	R:R:L198	6.79	Yes	No	0	2	5
182	R:R:N200	R:R:P199	4.89	No	No	6	4	4
183	R:R:D204	R:R:P199	6.44	Yes	No	6	2	4
184	R:R:D204	R:R:N200	13.46	Yes	No	6	2	4
185	R:R:D204	R:R:T203	4.34	Yes	No	0	2	3
186	R:R:D204	R:R:W207	8.93	Yes	No	0	2	5
187	R:R:L280	R:R:Y206	8.21	No	No	0	5	3
188	R:R:F208	R:R:W207	7.02	Yes	No	0	5	5
189	R:R:F208	R:R:Y211	4.13	Yes	Yes	1	5	3
190	R:R:F208	R:R:Q212	11.71	Yes	No	1	5	5
191	R:R:L280	R:R:T209	10.32	No	No	0	5	5
192	R:R:Q212	R:R:Y211	11.27	No	Yes	1	5	3
193	R:R:L215	R:R:Y211	3.52	No	Yes	0	4	3
194	R:R:F213	R:R:F217	7.5	Yes	No	1	5	8
195	R:R:A218	R:R:F213	4.16	No	Yes	0	5	5
196	R:R:F213	R:R:Y273	3.09	Yes	Yes	1	5	8
197	R:R:F213	R:R:L277	3.65	Yes	No	0	5	6
198	R:R:F214	R:R:L215	3.65	No	No	0	4	4
199	R:R:F214	R:R:L219	6.09	No	No	0	4	5
200	R:R:F217	R:R:F266	4.29	No	No	0	8	6
201	R:R:F217	R:R:Y273	5.16	No	Yes	1	8	8
202	R:R:L219	R:R:P220	3.28	No	Yes	0	5	9
203	R:R:L219	R:R:V223	2.98	No	No	0	5	6
204	R:R:F265	R:R:P220	5.78	Yes	Yes	1	9	9
205	R:R:F221	R:R:T225	7.78	No	No	0	6	5
206	R:R:F221	R:R:F265	3.22	No	Yes	0	6	9
207	R:R:F221	R:R:F266	13.93	No	No	0	6	6
208	R:R:C262	R:R:T225	5.07	No	No	0	8	5
209	R:R:A258	R:R:Y228	4	No	Yes	0	8	9
210	R:R:I261	R:R:Y228	6.04	No	Yes	0	8	9
211	R:R:C262	R:R:Y228	4.03	No	Yes	0	8	9
212	R:R:Q233	R:R:R230	7.01	No	No	0	3	4
213	R:R:R230	R:R:R234	6.4	No	No	0	4	6
214	R:R:L232	R:R:V254	2.98	No	No	0	5	7
215	R:R:L232	R:R:T255	8.84	No	No	0	5	6
216	R:R:A258	R:R:L232	3.15	No	No	0	8	5
217	R:R:M235	R:R:T251	7.53	No	No	0	8	7
218	R:R:M235	R:R:V254	6.09	No	No	0	8	7
219	R:R:I247	R:R:T236	4.56	Yes	No	0	4	4
220	R:R:A240	R:R:I247	3.25	No	Yes	0	4	4
221	R:R:P241	R:R:Q244	7.9	No	No	0	3	4
222	R:R:I247	R:R:P241	3.39	Yes	No	0	4	3
223	R:R:Q244	R:R:S246	11.55	No	No	0	4	4
224	R:R:R245	R:R:R248	3.2	No	No	0	4	4
225	R:R:I247	R:R:R250	3.76	Yes	No	0	4	6
226	R:R:L249	R:R:R253	8.5	No	No	0	4	7
227	R:R:E316	R:R:R253	6.98	No	No	0	5	7
228	R:R:I259	R:R:T255	3.04	No	No	0	5	6
229	R:R:L314	R:R:R256	6.07	Yes	No	0	7	7
230	R:R:L314	R:R:T257	10.32	Yes	No	0	7	8
231	R:R:L263	R:R:V267	2.98	No	No	0	5	6
232	R:R:F265	R:R:W269	6.01	Yes	Yes	1	9	8
233	R:R:A270	R:R:F266	8.32	No	No	0	5	6
234	R:R:C268	R:R:N303	6.3	Yes	No	0	8	9
235	R:R:W269	R:R:Y272	3.86	Yes	Yes	1	8	7
236	R:R:W269	R:R:Y273	3.86	Yes	Yes	1	8	8
237	R:R:G300	R:R:W269	5.63	No	Yes	0	7	8
238	R:R:N303	R:R:W269	15.82	No	Yes	0	9	8
239	R:R:Y272	R:R:Y273	13.9	Yes	Yes	1	7	8
240	R:R:Q276	R:R:Y272	6.76	Yes	Yes	1	5	7
241	R:R:Y272	R:R:Y293	3.97	Yes	Yes	1	7	3
242	R:R:L275	R:R:Y293	5.86	No	Yes	0	4	3
243	R:R:Q276	R:R:Q279	8.96	Yes	No	1	5	3
244	R:R:Q276	R:R:Y293	9.02	Yes	Yes	1	5	3
245	R:R:F289	R:R:Q279	4.68	No	No	0	4	3
246	R:R:Q279	R:R:Y293	6.76	No	Yes	1	3	3
247	R:R:F289	R:R:P285	5.78	No	No	0	4	1
248	R:R:T286	R:R:T288	6.28	No	No	0	1	3
249	R:R:L287	R:R:Y291	3.52	No	No	0	2	3
250	R:R:I297	R:R:Y293	4.84	No	Yes	0	5	3
251	R:R:N303	R:R:N307	9.54	No	No	0	9	9
252	R:R:L314	R:R:V310	2.98	Yes	No	0	7	8
253	R:R:C315	R:R:Y311	6.72	No	No	0	8	9
254	R:R:F318	R:R:Y311	9.28	Yes	No	0	8	9
255	R:R:F318	R:R:I312	8.79	Yes	No	4	8	7
256	R:R:L314	R:R:V313	2.98	Yes	No	0	7	7
257	R:R:C315	R:R:T317	3.38	No	No	0	8	6
258	R:R:E316	R:R:T317	5.64	No	No	0	5	6
259	R:R:K320	R:R:T317	3	No	No	0	5	6
260	R:R:N294	R:R:V290	2.96	No	No	0	4	3
261	L:L:G10	R:R:Y272	2.9	No	Yes	0	0	7
262	R:R:P78	R:R:R155	2.88	No	Yes	0	8	6
263	L:L:V12	R:R:Q102	2.87	No	No	0	0	5
264	R:R:I80	R:R:N75	2.83	No	No	0	6	4
265	R:R:Q276	R:R:T209	2.83	Yes	No	0	5	5
266	R:R:G112	R:R:W109	2.81	No	Yes	0	7	8
267	R:R:H147	R:R:S151	2.79	Yes	No	0	6	6
268	L:L:L5	R:R:L287	2.77	No	No	0	0	2
269	R:R:F47	R:R:S298	2.64	Yes	No	0	7	5
270	R:R:F154	R:R:S151	2.64	No	No	0	4	6
271	R:R:A121	R:R:W179	2.59	No	Yes	0	5	4
272	R:R:T117	R:R:W179	2.43	No	Yes	0	6	4
273	R:R:L249	R:R:R245	2.43	No	No	0	4	4
274	R:R:I41	R:R:Y38	2.42	No	No	0	4	4
275	R:R:I231	R:R:Y142	2.42	No	No	0	8	8
276	R:R:I231	R:R:Y228	2.42	No	Yes	0	8	9
277	R:R:L93	R:R:Y301	2.34	No	Yes	0	7	7
278	R:R:G189	R:R:G190	2.11	No	No	0	3	4
279	R:R:G95	R:R:P97	2.03	No	No	0	6	8
280	R:R:A270	R:R:P271	1.87	No	No	0	5	9
281	R:R:G107	R:R:V108	1.84	No	No	0	4	5
282	R:R:G193	R:R:V192	1.84	No	No	0	5	4
283	R:R:A302	R:R:C268	1.81	No	Yes	0	5	8
284	R:R:A138	R:R:A227	1.79	No	No	0	9	7
285	R:R:G57	R:R:I56	1.76	No	No	0	7	4
286	R:R:G105	R:R:M104	1.75	No	No	0	4	5
287	R:R:A240	R:R:S237	1.71	No	No	0	4	4
288	R:R:C268	R:R:V264	1.71	Yes	No	0	8	6
289	R:R:A295	R:R:S298	1.71	No	No	0	5	5
290	R:R:A191	R:R:V108	1.7	No	No	0	1	5
291	R:R:C165	R:R:T161	1.69	No	No	0	4	4
292	R:R:K156	R:R:P157	1.67	No	No	0	7	1
293	R:R:C51	R:R:I55	1.64	No	No	0	6	6
294	R:R:L299	R:R:P271	1.64	No	No	0	8	9
295	R:R:N200	R:R:P201	1.63	No	No	0	4	3
296	R:R:S237	R:R:S238	1.63	No	No	0	4	6
297	R:R:S45	R:R:V46	1.62	No	No	0	4	5
298	R:R:S158	R:R:V159	1.62	No	No	0	4	4
299	R:R:S237	R:R:V239	1.62	No	No	0	4	3
300	R:R:A242	R:R:I247	1.62	No	Yes	0	4	4
301	R:R:V159	R:R:V163	1.6	No	No	0	4	6
302	R:R:V264	R:R:V310	1.6	No	No	0	6	8
303	R:R:T225	R:R:V229	1.59	No	No	0	5	4
304	R:R:C268	R:R:L306	1.59	Yes	No	0	8	6
305	R:R:T278	R:R:V274	1.59	No	No	0	4	6
306	R:R:C305	R:R:L306	1.59	Yes	No	0	8	6
307	R:R:A260	R:R:L314	1.58	No	Yes	0	6	7
308	R:R:A296	R:R:L275	1.58	No	No	0	6	4
309	R:R:T236	R:R:T251	1.57	No	No	0	4	7
310	R:R:I55	R:R:S59	1.55	No	No	0	6	3
311	R:R:I62	R:R:V66	1.54	No	No	0	7	3
312	R:R:I83	R:R:V66	1.54	No	No	0	6	3
313	R:R:H147	R:R:P148	1.53	Yes	No	0	6	8
314	R:R:I80	R:R:T161	1.52	No	No	0	6	4
315	R:R:I173	R:R:T176	1.52	No	No	0	4	4
316	R:R:F47	R:R:G48	1.51	Yes	No	0	7	3
317	R:R:M115	R:R:T114	1.51	No	No	0	6	3
318	R:R:K153	R:R:T152	1.5	No	No	0	3	5
319	R:R:L275	R:R:T278	1.47	No	No	0	4	4
320	R:R:L287	R:R:T286	1.47	No	No	0	2	1
321	R:R:P285	R:R:R284	1.44	No	No	0	1	2
322	R:R:I62	R:R:L90	1.43	No	No	0	7	8
323	R:R:H72	R:R:S69	1.39	No	No	0	7	6
324	R:R:L210	R:R:L277	1.38	No	No	0	4	6
325	R:R:F63	R:R:V326	1.31	No	No	0	3	6
326	R:R:F154	R:R:K153	1.24	No	No	0	4	3
327	R:R:E316	R:R:R319	1.16	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R11	8.00167	6	1	0
2	L:L:Y13	9.612	5	3	0
3	R:R:F47	5.33	5	1	7
4	R:R:V88	4.4775	4	1	8
5	R:R:D89	8.6875	4	0	9
6	R:R:F92	6.29833	6	1	7
7	R:R:M96	7.072	5	1	7
8	R:R:I100	6.2825	4	1	6
9	R:R:W109	7.11875	8	2	8
10	R:R:F111	8.62	4	2	6
11	R:R:I119	4.535	4	2	5
12	R:R:D123	7.0125	4	1	6
13	R:R:N125	6.51	5	1	5
14	R:R:Q127	7.338	5	1	8
15	R:R:F128	5.82167	6	1	6
16	R:R:T129	6.722	5	1	7
17	R:R:H147	4.114	5	5	6
18	R:R:R155	5.868	5	0	6
19	R:R:W179	4.7275	4	0	4
20	R:R:F187	11.1875	4	3	1
21	R:R:D204	7.992	5	6	2
22	R:R:F208	7.5425	4	1	5
23	R:R:Y211	6.4675	4	1	3
24	R:R:F213	4.6	4	1	5
25	R:R:P220	4.015	4	1	9
26	R:R:Y228	5.18167	6	0	9
27	R:R:I247	3.316	5	0	4
28	R:R:F265	5.532	5	1	9
29	R:R:C268	2.8525	4	0	8
30	R:R:W269	7.14167	6	1	8
31	R:R:Y272	7.11833	6	1	7
32	R:R:Y273	6.33	5	1	8
33	R:R:Q276	6.8925	4	1	5
34	R:R:Y293	7.07	6	1	3
35	R:R:Y301	7.14167	6	1	7
36	R:R:C305	3.385	4	0	8
37	R:R:L314	4.786	5	0	7
38	R:R:F318	6.8675	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M4	R:R:Y291	11.4928	4.79	No	No	0	0	3
2	L:L:F2	L:L:M4	12.7496	4.98	No	No	0	0	0
3	L:L:F2	L:L:R6	18.973	12.83	No	No	0	0	0
4	L:L:R6	L:L:Y13	20.0752	11.32	No	Yes	3	0	0
5	L:L:M8	R:R:Y293	53.9536	11.97	No	Yes	0	0	3
6	L:L:M8	L:L:Y13	52.892	7.18	No	Yes	0	0	0
7	R:R:Y272	R:R:Y293	50.7932	3.97	Yes	Yes	1	7	3
8	L:L:R11	R:R:Y272	28.7614	11.32	Yes	Yes	1	0	7
9	L:L:R11	R:R:Q127	26.1033	15.19	Yes	Yes	1	0	8
10	R:R:F128	R:R:Q127	43.4493	3.51	Yes	Yes	1	6	8
11	R:R:F128	R:R:Q212	24.3421	3.51	Yes	No	1	6	5
12	R:R:F208	R:R:Q212	16.1257	11.71	Yes	No	1	5	5
13	R:R:I297	R:R:Y293	13.3496	4.84	No	Yes	0	5	3
14	L:L:R11	R:R:I297	13.9231	5.01	Yes	No	0	0	5
15	R:R:W269	R:R:Y272	51.4236	3.86	Yes	Yes	1	8	7
16	R:R:Q127	R:R:W269	47.5717	7.67	Yes	Yes	1	8	8
17	L:L:R11	R:R:Y301	33.9008	4.12	Yes	Yes	1	0	7
18	L:L:Y13	R:R:Q102	27.4049	10.15	Yes	No	0	0	5
19	L:L:V12	R:R:Q102	10.2278	2.87	No	No	0	0	5
20	R:R:F208	R:R:W207	17.226	7.02	Yes	No	0	5	5
21	R:R:D204	R:R:W207	19.4529	8.93	Yes	No	0	2	5
22	R:R:M96	R:R:Y301	24.6736	17.96	Yes	Yes	1	7	7
23	R:R:F47	R:R:M96	14.155	4.98	Yes	Yes	1	7	7
24	R:R:F47	R:R:S298	11.0128	2.64	Yes	No	0	7	5
25	R:R:I100	R:R:Y301	22.7781	3.63	Yes	Yes	1	6	7
26	R:R:F47	R:R:I100	14.0492	11.3	Yes	Yes	1	7	6
27	R:R:F47	R:R:M43	10.6691	6.22	Yes	No	0	7	5
28	R:R:N303	R:R:W269	31.2792	15.82	No	Yes	0	9	8
29	R:R:C268	R:R:N303	14.7427	6.3	Yes	No	0	8	9
30	R:R:F92	R:R:S304	13.6709	6.61	Yes	No	0	7	9
31	R:R:D89	R:R:S304	12.9469	11.78	Yes	No	0	9	9
32	R:R:D89	R:R:N58	26.6789	5.39	Yes	No	0	9	9
33	R:R:N303	R:R:N307	18.6476	9.54	No	No	0	9	9
34	R:R:D89	R:R:N307	18.1127	8.08	Yes	No	0	9	9
35	R:R:N58	R:R:S86	24.6288	2.98	No	No	0	9	9
36	R:R:S86	R:R:V61	18.3811	3.23	No	No	0	9	9
37	R:R:F318	R:R:V61	15.1454	5.24	Yes	No	4	8	9
38	R:R:F265	R:R:W269	100	6.01	Yes	Yes	1	9	8
39	R:R:F265	R:R:L134	47.9459	4.87	Yes	No	0	9	8
40	R:R:I224	R:R:L134	47.529	4.28	No	No	0	8	8
41	R:R:A138	R:R:I224	62.3327	4.87	No	No	0	9	8
42	R:R:A138	R:R:Y228	61.2548	5.34	No	Yes	0	9	9
43	R:R:R141	R:R:Y228	40.7952	9.26	No	Yes	0	9	9
44	R:R:M137	R:R:R141	39.52	9.93	No	No	0	9	9
45	R:R:F81	R:R:M137	38.255	7.46	No	No	0	7	9
46	R:R:D140	R:R:F81	29.455	4.78	No	No	0	8	7
47	R:R:D140	R:R:R155	28.1879	9.53	No	Yes	0	8	6
48	R:R:P78	R:R:R155	48.0761	2.88	No	Yes	0	8	6
49	R:R:N76	R:R:P78	21.4704	8.15	No	No	0	8	8
50	R:R:D79	R:R:N76	18.7777	12.12	No	No	0	8	8
51	R:R:D79	R:R:R321	16.0789	8.34	No	No	0	8	5
52	R:R:F221	R:R:F265	48.6028	3.22	No	Yes	0	6	9
53	R:R:F221	R:R:T225	49.4407	7.78	No	No	0	6	5
54	R:R:C262	R:R:T225	48.5784	5.07	No	No	0	8	5
55	R:R:C262	R:R:Y228	48.1615	4.03	No	Yes	0	8	9
56	R:R:I231	R:R:Y228	45.961	2.42	No	Yes	0	8	9
57	R:R:I231	R:R:Y142	43.4269	2.42	No	No	0	8	8
58	R:R:H147	R:R:Y142	36.866	6.53	Yes	No	5	6	8
59	R:R:H147	R:R:S151	33.3638	2.79	Yes	No	0	6	6
60	R:R:R155	R:R:S151	28.2632	3.95	Yes	No	0	6	6
61	R:R:K68	R:R:R321	10.8562	18.56	No	No	0	5	5
62	R:R:P78	R:R:V77	24.3421	3.53	No	No	0	8	6
63	R:R:P157	R:R:V77	18.9607	5.3	No	No	0	1	6
64	R:R:F318	R:R:Y311	12.0439	9.28	Yes	No	0	8	9
65	R:R:F128	R:R:I175	12.2697	3.77	Yes	No	0	6	7
66	R:R:Q102	R:R:W109	16.4348	7.67	No	Yes	0	5	8
67	R:R:P177	R:R:Y211	14.3624	6.95	No	Yes	0	8	3
68	R:R:K156	R:R:P157	16.264	1.67	No	No	0	7	1
69	R:R:K156	R:R:S158	13.5631	3.06	No	No	0	7	4
70	R:R:S158	R:R:V159	10.8582	1.62	No	No	0	4	4
71	R:R:F214	R:R:L219	15.2227	6.09	No	No	0	4	5
72	R:R:A258	R:R:Y228	25.3549	4	No	Yes	0	8	9
73	R:R:A258	R:R:L232	23.9719	3.15	No	No	0	8	5
74	R:R:L232	R:R:V254	19.8088	2.98	No	No	0	5	7
75	R:R:M235	R:R:V254	18.4157	6.09	No	No	0	8	7
76	R:R:M235	R:R:T251	17.0165	7.53	No	No	0	8	7
77	R:R:T236	R:R:T251	15.6986	1.57	No	No	0	4	7
78	R:R:I247	R:R:T236	14.2933	4.56	Yes	No	0	4	4
79	R:R:F92	R:R:Q127	20.6671	4.68	Yes	Yes	1	7	8
80	R:R:L215	R:R:Y211	14.0492	3.52	No	Yes	0	4	3
81	R:R:F214	R:R:L215	14.9441	3.65	No	No	0	4	4
82	R:R:F92	R:R:Y301	16.5243	11.35	Yes	Yes	1	7	7
83	R:R:I224	R:R:T135	15.363	7.6	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:D1	R:R:N40	5.39	0	No	No	0	4	0	1
L:L:F2	R:R:G107	4.52	0	No	No	0	4	0	1
L:L:M4	R:R:Y291	4.79	0	No	No	0	3	0	1
L:L:R6	R:R:F187	23.52	3	No	Yes	0	1	0	1
L:L:C7	R:R:P285	3.77	0	No	No	0	1	0	1
L:L:M8	R:R:Y293	11.97	0	No	Yes	0	3	0	1
L:L:L9	R:R:L205	4.15	0	No	No	0	5	0	1
L:L:L9	R:R:F208	7.31	0	No	Yes	0	5	0	1
L:L:R11	R:R:F92	6.41	1	Yes	Yes	0	7	0	1
L:L:R11	R:R:D123	5.96	1	Yes	Yes	0	6	0	1
L:L:R11	R:R:Q127	15.19	1	Yes	Yes	0	8	0	1
L:L:R11	R:R:Y272	11.32	1	Yes	Yes	0	7	0	1
L:L:R11	R:R:I297	5.01	1	Yes	No	0	5	0	1
L:L:R11	R:R:Y301	4.12	1	Yes	Yes	0	7	0	1
L:L:V12	R:R:G195	3.68	0	No	No	0	3	0	1
L:L:V12	R:R:I196	3.07	0	No	No	0	4	0	1
L:L:Y13	R:R:Q102	10.15	3	Yes	No	0	5	0	1
L:L:Y13	R:R:L103	7.03	3	Yes	No	0	4	0	1
L:L:Y13	R:R:F187	12.38	3	Yes	Yes	0	1	0	1
L:L:P15	R:R:I185	3.39	0	No	No	0	2	0	1
L:L:P15	R:R:R197	4.32	0	No	No	0	3	0	1
L:L:W17	R:R:P201	4.05	0	No	No	0	3	0	1
L:L:W17	R:R:D202	21.22	0	No	No	0	2	0	1
R:R:I39	R:R:N40	7.08	0	No	No	3	4	2	1
R:R:I39	R:R:Y291	4.84	0	No	No	3	3	2	1
R:R:D123	R:R:F92	4.78	1	Yes	Yes	6	7	1	1
R:R:F92	R:R:S126	3.96	1	Yes	No	7	8	1	2
R:R:F92	R:R:Q127	4.68	1	Yes	Yes	7	8	1	1
R:R:F92	R:R:Y301	11.35	1	Yes	Yes	7	7	1	1
R:R:F92	R:R:S304	6.61	1	Yes	No	7	9	1	2
R:R:I100	R:R:M96	5.83	1	Yes	Yes	6	7	2	2
R:R:M96	R:R:Y301	17.96	1	Yes	Yes	7	7	2	1
R:R:D123	R:R:M99	13.86	1	Yes	No	6	6	1	2
R:R:I100	R:R:Y301	3.63	1	Yes	Yes	6	7	2	1
R:R:Q102	R:R:W109	7.67	0	No	Yes	5	8	1	2
R:R:D123	R:R:Y301	3.45	1	Yes	Yes	6	7	1	1
R:R:F128	R:R:Q127	3.51	1	Yes	Yes	6	8	2	1
R:R:Q127	R:R:W269	7.67	1	Yes	Yes	8	8	1	2
R:R:Q127	R:R:Y273	5.64	1	Yes	Yes	8	8	1	2
R:R:F128	R:R:Q212	3.51	1	Yes	No	6	5	2	2
R:R:R183	R:R:R197	4.26	0	No	No	4	3	2	1
R:R:I185	R:R:P186	3.39	0	No	No	2	2	1	2
R:R:G195	R:R:I185	3.53	0	No	No	3	2	1	1
R:R:F187	R:R:P188	4.33	3	Yes	No	1	3	1	2
R:R:F187	R:R:G193	4.52	3	Yes	No	1	5	1	2
R:R:F208	R:R:W207	7.02	1	Yes	No	5	5	1	2
R:R:F208	R:R:Y211	4.13	1	Yes	Yes	5	3	1	2
R:R:F208	R:R:Q212	11.71	1	Yes	No	5	5	1	2
R:R:Q212	R:R:Y211	11.27	1	No	Yes	5	3	2	2
R:R:W269	R:R:Y272	3.86	1	Yes	Yes	8	7	2	1
R:R:W269	R:R:Y273	3.86	1	Yes	Yes	8	8	2	2
R:R:Y272	R:R:Y273	13.9	1	Yes	Yes	7	8	1	2
R:R:Q276	R:R:Y272	6.76	1	Yes	Yes	5	7	2	1
R:R:Y272	R:R:Y293	3.97	1	Yes	Yes	7	3	1	1
R:R:L275	R:R:Y293	5.86	0	No	Yes	4	3	2	1
R:R:Q276	R:R:Q279	8.96	1	Yes	No	5	3	2	2
R:R:Q276	R:R:Y293	9.02	1	Yes	Yes	5	3	2	1
R:R:F289	R:R:Q279	4.68	0	No	No	4	3	2	2
R:R:Q279	R:R:Y293	6.76	1	No	Yes	3	3	2	1
R:R:F289	R:R:P285	5.78	0	No	No	4	1	2	1
R:R:L287	R:R:Y291	3.52	0	No	No	2	3	1	1
R:R:I297	R:R:Y293	4.84	0	No	Yes	5	3	1	1
L:L:G10	R:R:Y272	2.9	0	No	Yes	0	7	0	1
L:L:V12	R:R:Q102	2.87	0	No	No	0	5	0	1
L:L:L5	R:R:L287	2.77	0	No	No	0	2	0	1
R:R:L93	R:R:Y301	2.34	0	No	Yes	7	7	2	1
R:R:G107	R:R:V108	1.84	0	No	No	4	5	1	2
R:R:N200	R:R:P201	1.63	6	No	No	4	3	2	1
R:R:L287	R:R:T286	1.47	0	No	No	2	1	1	2
R:R:P285	R:R:R284	1.44	0	No	No	1	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WWM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	286
Number of Links	327
Number of Hubs	38
Number of Links mediated by Hubs	152
Number of Communities	6
Number of Nodes involved in Communities	54
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	100655
Length Of Smallest Path	3
Average Path Length	15.4285
Length of Longest Path	35
Minimum Path Strength	1.37
Average Path Strength	6.10247
Maximum Path Strength	18.175
Minimum Path Correlation	0.7
Average Path Correlation	0.925213
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.0459
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.4638
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • melanin-concentrating hormone receptor activity • protein-hormone receptor activity • hormone binding • neuropeptide signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • metabolic process • generation of precursor metabolites and energy • behavior • feeding behavior • ciliary membrane • plasma membrane region • cell projection membrane • melanin-concentrating hormone receptor binding • type 1 melanin-concentrating hormone receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • melanin-concentrating hormone activity • receptor ligand activity • signaling receptor activator activity • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission, dopaminergic • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • trans-synaptic signaling • regulation of signaling • regulation of synaptic transmission, dopaminergic • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • synaptic transmission, dopaminergic • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99705
Sequence	>8WWM_nogp_Chain_R Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S K L H W C N N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G N G V W H F G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H P I S S T K F R K P S V A T L V I C L L W A L S F I S I T P V W L Y A R L I P F P G G A V G C G I R L P N P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M T S S V A P A S Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I S R P T L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T F R K R L V L S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published

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