psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:F2	17.91	No	No	0	0	0
2	L:L:M4	L:L:R6	11.17	No	No	0	0	0
3	L:L:M4	R:R:P257	3.35	No	No	0	0	3
4	L:L:L5	R:R:V359	4.47	No	No	0	0	3
5	L:L:R6	R:R:F256	6.41	No	No	0	0	1
6	L:L:C7	L:L:R14	8.36	No	No	0	0	0
7	L:L:C16	L:L:C7	7.28	No	No	0	0	0
8	L:L:M8	L:L:Y13	4.79	No	No	0	0	0
9	L:L:M8	R:R:Y362	4.79	No	Yes	0	0	3
10	L:L:L9	L:L:R14	7.29	Yes	No	1	0	0
11	L:L:L9	R:R:I265	4.28	Yes	No	0	0	4
12	L:L:L9	R:R:L274	4.15	Yes	No	0	0	5
13	L:L:L9	R:R:Q345	3.99	Yes	Yes	1	0	5
14	L:L:L9	R:R:Q348	3.99	Yes	Yes	1	0	3
15	L:L:R11	R:R:F161	6.41	No	Yes	1	0	7
16	L:L:R11	R:R:D192	9.53	No	No	1	0	6
17	L:L:R11	R:R:Q196	9.35	No	Yes	1	0	8
18	L:L:V12	R:R:Q171	8.6	No	No	0	0	5
19	L:L:V12	R:R:G264	3.68	No	No	0	0	3
20	L:L:V12	R:R:I265	6.14	No	No	0	0	4
21	L:L:Y13	R:R:L172	3.52	No	No	0	0	4
22	L:L:R14	R:R:Q348	9.35	No	Yes	1	0	3
23	L:L:P15	R:R:I254	8.47	No	Yes	4	0	2
24	L:L:P15	R:R:R266	12.97	No	Yes	4	0	3
25	L:L:C16	R:R:F256	11.17	No	No	0	0	1
26	L:L:W17	R:R:R353	13	No	No	0	0	2
27	L:L:Q18	R:R:R266	10.51	No	Yes	4	0	3
28	L:L:Q18	R:R:P270	3.16	No	No	4	0	3
29	R:R:I108	R:R:Y107	7.25	No	No	0	3	4
30	R:R:N109	R:R:Y107	6.98	No	No	0	4	4
31	R:R:I110	R:R:N109	4.25	No	No	0	4	4
32	R:R:M112	R:R:P113	6.71	No	No	0	5	5
33	R:R:M173	R:R:P113	6.71	No	No	0	5	5
34	R:R:F116	R:R:M165	3.73	Yes	Yes	1	7	7
35	R:R:F116	R:R:I169	15.07	Yes	No	1	7	6
36	R:R:F116	R:R:I366	3.77	Yes	No	1	7	5
37	R:R:F116	R:R:S367	3.96	Yes	No	0	7	5
38	R:R:F116	R:R:Y370	4.13	Yes	Yes	1	7	7
39	R:R:A371	R:R:I119	4.87	No	No	0	5	7
40	R:R:C374	R:R:I119	3.27	No	No	0	8	7
41	R:R:C120	R:R:L162	3.17	Yes	No	0	6	7
42	R:R:C120	R:R:M165	4.86	Yes	Yes	0	6	7
43	R:R:F378	R:R:L122	3.65	No	No	0	6	5
44	R:R:I125	R:R:S128	3.1	No	No	0	4	3
45	R:R:F378	R:R:G126	3.01	No	No	0	6	7
46	R:R:N127	R:R:S155	2.98	Yes	Yes	0	9	9
47	R:R:D158	R:R:N127	5.39	Yes	Yes	6	9	9
48	R:R:L159	R:R:N127	6.87	No	Yes	0	8	9
49	R:R:N127	R:R:P377	6.52	Yes	No	6	9	9
50	R:R:S155	R:R:V130	4.85	Yes	No	0	9	9
51	R:R:I381	R:R:V130	3.07	No	No	0	7	9
52	R:R:I131	R:R:S155	3.1	Yes	Yes	0	7	9
53	R:R:F132	R:R:K136	12.41	No	No	0	3	5
54	R:R:A133	R:R:F387	4.16	No	Yes	0	7	8
55	R:R:I152	R:R:V134	7.68	No	No	0	6	7
56	R:R:D148	R:R:K137	5.53	No	No	0	8	5
57	R:R:K137	R:R:R390	17.33	No	Yes	0	5	5
58	R:R:C143	R:R:S138	3.44	Yes	No	0	8	6
59	R:R:C143	R:R:N145	4.72	Yes	No	7	8	8
60	R:R:C143	R:R:D148	4.67	Yes	No	7	8	8
61	R:R:D148	R:R:N145	9.42	No	No	7	8	8
62	R:R:P147	R:R:V146	3.53	No	Yes	0	8	6
63	R:R:D209	R:R:V146	4.38	No	Yes	0	8	6
64	R:R:A229	R:R:V146	3.39	No	Yes	0	7	6
65	R:R:A205	R:R:F150	4.16	No	Yes	0	7	7
66	R:R:F150	R:R:M206	4.98	Yes	No	0	7	9
67	R:R:I151	R:R:S155	3.1	No	Yes	0	8	9
68	R:R:I151	R:R:Y380	13.3	No	No	0	8	9
69	R:R:I202	R:R:N153	8.5	No	No	0	8	9
70	R:R:I233	R:R:N153	8.5	No	No	0	7	9
71	R:R:N153	R:R:W237	9.04	No	Yes	0	9	9
72	R:R:D158	R:R:L154	8.14	Yes	No	0	9	9
73	R:R:I202	R:R:L154	5.71	No	No	0	8	9
74	R:R:L154	R:R:N376	5.49	No	No	0	9	9
75	R:R:T198	R:R:V157	6.35	No	No	8	7	8
76	R:R:S199	R:R:V157	3.23	No	No	0	9	8
77	R:R:V157	R:R:W237	3.68	No	Yes	8	8	9
78	R:R:D158	R:R:S199	4.42	Yes	No	0	9	9
79	R:R:D158	R:R:S373	5.89	Yes	No	0	9	9
80	R:R:D158	R:R:P377	3.22	Yes	No	6	9	9
81	R:R:D192	R:R:F161	8.36	No	Yes	1	6	7
82	R:R:F161	R:R:S195	7.93	Yes	No	0	7	8
83	R:R:F161	R:R:Q196	5.86	Yes	Yes	1	7	8
84	R:R:F161	R:R:Y370	6.19	Yes	Yes	1	7	7
85	R:R:F161	R:R:S373	7.93	Yes	No	0	7	9
86	R:R:L162	R:R:S373	3	No	No	0	7	9
87	R:R:M165	R:R:P166	6.71	Yes	No	0	7	8
88	R:R:I169	R:R:M165	8.75	No	Yes	1	6	7
89	R:R:M165	R:R:Y370	15.57	Yes	Yes	1	7	7
90	R:R:F167	R:R:F180	7.5	No	Yes	0	6	6
91	R:R:F167	R:R:I188	10.05	No	No	0	6	5
92	R:R:M168	R:R:T189	3.01	No	No	0	6	5
93	R:R:D192	R:R:M168	9.7	No	No	0	6	6
94	R:R:I169	R:R:Y370	3.63	No	Yes	1	6	7
95	R:R:H170	R:R:W178	11.64	No	No	9	4	8
96	R:R:H170	R:R:H179	3.58	No	No	0	4	2
97	R:R:F180	R:R:H170	9.05	Yes	No	9	6	4
98	R:R:Q171	R:R:W178	10.95	No	No	0	5	8
99	R:R:C263	R:R:Q171	4.58	No	No	0	9	5
100	R:R:L172	R:R:N363	13.73	No	No	0	4	4
101	R:R:H179	R:R:V177	5.54	No	No	0	2	5
102	R:R:F180	R:R:W178	12.03	Yes	No	9	6	8
103	R:R:L187	R:R:M184	4.24	No	No	0	4	6
104	R:R:I188	R:R:M184	5.83	No	No	0	5	6
105	R:R:C185	R:R:C263	7.28	No	No	10	9	9
106	R:R:T186	R:R:W248	3.64	No	No	0	6	4
107	R:R:T189	R:R:V247	4.76	No	No	0	5	5
108	R:R:A193	R:R:I244	4.87	No	Yes	0	4	7
109	R:R:N194	R:R:S240	10.43	No	No	0	5	8
110	R:R:F241	R:R:N194	10.87	No	No	0	4	5
111	R:R:I244	R:R:N194	5.66	Yes	No	0	7	5
112	R:R:Q196	R:R:W338	14.24	Yes	Yes	1	8	8
113	R:R:Q196	R:R:Y342	3.38	Yes	Yes	0	8	8
114	R:R:F197	R:R:Y201	5.16	Yes	Yes	5	6	6
115	R:R:F197	R:R:S243	7.93	Yes	Yes	5	6	5
116	R:R:F197	R:R:I244	11.3	Yes	Yes	5	6	7
117	R:R:F197	R:R:L284	4.87	Yes	No	5	6	4
118	R:R:T198	R:R:W237	6.06	No	Yes	8	7	9
119	R:R:S240	R:R:T198	4.8	No	No	0	8	7
120	R:R:P289	R:R:T200	3.5	No	No	0	9	8
121	R:R:L236	R:R:Y201	3.52	No	Yes	0	7	6
122	R:R:S243	R:R:Y201	3.82	Yes	Yes	5	5	6
123	R:R:L284	R:R:Y201	3.52	No	Yes	5	4	6
124	R:R:I293	R:R:L203	4.28	Yes	No	0	8	8
125	R:R:F334	R:R:L203	3.65	Yes	No	0	9	8
126	R:R:I208	R:R:T204	3.04	No	Yes	2	6	7
127	R:R:P289	R:R:T204	5.25	No	Yes	0	9	7
128	R:R:T204	R:R:V292	3.17	Yes	Yes	2	7	6
129	R:R:I293	R:R:T204	4.56	Yes	Yes	2	8	7
130	R:R:M206	R:R:R210	13.65	No	No	0	9	9
131	R:R:A207	R:R:I293	4.87	No	Yes	2	9	8
132	R:R:A207	R:R:Y297	4	No	Yes	2	9	9
133	R:R:I208	R:R:V292	3.07	No	Yes	2	6	6
134	R:R:D209	R:R:R224	8.34	No	No	0	8	6
135	R:R:R210	R:R:Y297	5.14	No	Yes	0	9	9
136	R:R:V215	R:R:Y211	7.57	No	Yes	0	7	8
137	R:R:R299	R:R:Y211	5.14	No	Yes	0	4	8
138	R:R:F223	R:R:L212	3.65	No	No	0	4	4
139	R:R:A213	R:R:R224	4.15	No	No	0	8	6
140	R:R:I300	R:R:T214	13.68	No	No	0	8	9
141	R:R:H216	R:R:V215	8.3	No	No	0	6	7
142	R:R:R303	R:R:V215	6.54	No	No	0	6	7
143	R:R:R224	R:R:S220	5.27	No	No	0	6	6
144	R:R:K225	R:R:P226	3.35	No	No	0	7	1
145	R:R:F241	R:R:W237	5.01	No	Yes	0	4	9
146	R:R:S240	R:R:S243	3.26	No	Yes	0	8	5
147	R:R:I244	R:R:S243	6.19	Yes	Yes	5	7	5
148	R:R:I244	R:R:V247	4.61	Yes	No	0	7	5
149	R:R:P246	R:R:T245	3.5	No	No	0	8	4
150	R:R:L249	R:R:W248	3.42	No	No	0	5	4
151	R:R:L267	R:R:Y250	7.03	No	Yes	0	5	5
152	R:R:P268	R:R:Y250	4.17	No	Yes	3	4	5
153	R:R:W276	R:R:Y250	6.75	No	Yes	3	5	5
154	R:R:F277	R:R:Y250	3.09	Yes	Yes	3	5	5
155	R:R:L253	R:R:V261	10.43	No	No	0	5	4
156	R:R:I254	R:R:P255	3.39	Yes	No	0	2	2
157	R:R:G264	R:R:I254	3.53	No	Yes	0	3	2
158	R:R:I254	R:R:R266	3.76	Yes	Yes	4	2	3
159	R:R:F256	R:R:P257	4.33	No	No	0	1	3
160	R:R:P270	R:R:R266	12.97	No	Yes	4	3	3
161	R:R:D273	R:R:L267	16.29	Yes	No	0	2	5
162	R:R:N269	R:R:P268	3.26	No	No	3	4	4
163	R:R:D273	R:R:P268	4.83	Yes	No	3	2	4
164	R:R:N269	R:R:T272	7.31	No	No	0	4	3
165	R:R:D273	R:R:N269	13.46	Yes	No	3	2	4
166	R:R:D273	R:R:W276	7.82	Yes	No	3	2	5
167	R:R:L274	R:R:L349	6.92	No	No	0	5	5
168	R:R:L279	R:R:Y275	10.55	No	No	0	4	3
169	R:R:F277	R:R:W276	7.02	Yes	No	3	5	5
170	R:R:F277	R:R:Q281	14.05	Yes	No	0	5	5
171	R:R:Q345	R:R:T278	8.5	Yes	No	0	5	5
172	R:R:L349	R:R:T278	4.42	No	No	0	5	5
173	R:R:L284	R:R:Y280	5.86	No	No	0	4	3
174	R:R:Q281	R:R:Q345	5.12	No	Yes	0	5	5
175	R:R:F282	R:R:Y342	7.22	No	Yes	0	5	8
176	R:R:A287	R:R:F283	4.16	No	No	0	5	4
177	R:R:A285	R:R:Y342	5.34	No	Yes	0	5	8
178	R:R:F286	R:R:F334	6.43	No	Yes	1	8	9
179	R:R:F286	R:R:F335	6.43	No	Yes	0	8	6
180	R:R:F286	R:R:W338	4.01	No	Yes	1	8	8
181	R:R:L288	R:R:P289	4.93	No	No	0	5	9
182	R:R:L288	R:R:V292	2.98	No	Yes	0	5	6
183	R:R:F290	R:R:T294	7.78	No	No	0	6	5
184	R:R:F290	R:R:F334	7.5	No	Yes	0	6	9
185	R:R:F290	R:R:F335	9.65	No	Yes	0	6	6
186	R:R:I293	R:R:Y297	3.63	Yes	Yes	2	8	9
187	R:R:A327	R:R:Y297	4	No	Yes	0	8	9
188	R:R:I330	R:R:Y297	10.88	No	Yes	0	8	9
189	R:R:Q302	R:R:V298	5.73	No	No	0	3	4
190	R:R:Q302	R:R:R299	5.84	No	No	0	3	4
191	R:R:R299	R:R:R303	7.46	No	No	0	4	6
192	R:R:L301	R:R:V323	4.47	No	No	0	5	7
193	R:R:L301	R:R:T324	4.42	No	No	0	5	6
194	R:R:M304	R:R:T320	4.52	No	No	0	8	7
195	R:R:M304	R:R:V323	7.61	No	No	0	8	7
196	R:R:I316	R:R:P310	6.77	No	No	0	4	3
197	R:R:R317	R:R:S312	3.95	No	No	0	4	2
198	R:R:I316	R:R:R319	6.26	No	No	0	4	6
199	R:R:L318	R:R:R322	3.64	No	No	0	4	7
200	R:R:E385	R:R:R322	3.49	No	No	0	5	7
201	R:R:I330	R:R:T326	3.04	No	No	0	8	8
202	R:R:L383	R:R:T326	8.84	Yes	No	0	7	8
203	R:R:A329	R:R:L383	3.15	No	Yes	0	6	7
204	R:R:L332	R:R:V336	2.98	No	No	0	5	6
205	R:R:N372	R:R:V333	4.43	No	No	0	9	6
206	R:R:L375	R:R:V333	2.98	No	No	0	6	6
207	R:R:V333	R:R:V379	4.81	No	No	0	6	8
208	R:R:F334	R:R:W338	4.01	Yes	Yes	1	9	8
209	R:R:A339	R:R:F335	6.93	No	Yes	0	5	6
210	R:R:C337	R:R:N372	9.45	No	No	0	8	9
211	R:R:G369	R:R:W338	8.44	No	Yes	0	7	8
212	R:R:N372	R:R:W338	10.17	No	Yes	0	9	8
213	R:R:L368	R:R:P340	3.28	No	No	0	8	9
214	R:R:Y341	R:R:Y342	10.92	Yes	Yes	0	7	8
215	R:R:Q345	R:R:Y341	6.76	Yes	Yes	1	5	7
216	R:R:Y341	R:R:Y362	5.96	Yes	Yes	1	7	3
217	R:R:F358	R:R:L344	6.09	No	Yes	0	4	4
218	R:R:Q345	R:R:Q348	3.84	Yes	Yes	1	5	3
219	R:R:Q345	R:R:Y362	3.38	Yes	Yes	1	5	3
220	R:R:F358	R:R:Q348	9.37	No	Yes	0	4	3
221	R:R:Q348	R:R:Y362	7.89	Yes	Yes	1	3	3
222	R:R:P354	R:R:V359	3.53	No	No	0	1	3
223	R:R:I366	R:R:Y362	4.84	No	Yes	1	5	3
224	R:R:I366	R:R:Y370	3.63	No	Yes	1	5	7
225	R:R:N376	R:R:P377	4.89	No	No	0	9	9
226	R:R:F387	R:R:Y380	11.35	Yes	No	0	8	9
227	R:R:F387	R:R:I381	7.54	Yes	No	0	8	7
228	R:R:L383	R:R:V382	2.98	Yes	No	0	7	7
229	R:R:E385	R:R:T386	8.47	No	No	0	5	6
230	R:R:F387	R:R:R390	3.21	Yes	Yes	0	8	5
231	R:R:N363	R:R:V359	2.96	No	No	0	4	3
232	R:R:L344	R:R:T347	2.95	Yes	No	0	4	4
233	R:R:I131	R:R:I152	2.94	Yes	No	0	7	6
234	R:R:I111	R:R:M112	2.92	No	No	0	6	5
235	R:R:C384	R:R:F387	2.79	No	Yes	0	8	8
236	L:L:L5	R:R:L356	2.77	No	No	0	0	2
237	R:R:L159	R:R:L163	2.77	No	No	0	8	5
238	R:R:L235	R:R:L239	2.77	No	No	0	4	4
239	R:R:A287	R:R:F282	2.77	No	No	0	5	5
240	R:R:C331	R:R:Y297	2.69	No	Yes	0	8	9
241	R:R:A296	R:R:Y211	2.67	No	Yes	0	7	8
242	R:R:A365	R:R:Y341	2.67	No	Yes	0	6	7
243	R:R:E182	R:R:L253	2.65	No	No	0	2	5
244	R:R:F150	R:R:V146	2.62	Yes	Yes	0	7	6
245	R:R:F150	R:R:V232	2.62	Yes	No	0	7	6
246	R:R:R319	R:R:T305	2.59	No	No	0	6	4
247	R:R:R390	R:R:T386	2.59	Yes	No	0	5	6
248	R:R:F116	R:R:M112	2.49	Yes	No	0	7	5
249	R:R:F223	R:R:K222	2.48	No	No	0	4	3
250	R:R:K321	R:R:R325	2.48	No	No	0	5	7
251	R:R:L383	R:R:R325	2.43	Yes	No	0	7	7
252	R:R:I300	R:R:Y211	2.42	No	Yes	0	8	8
253	R:R:I300	R:R:Y297	2.42	No	Yes	0	8	9
254	R:R:L212	R:R:Y211	2.34	No	Yes	0	4	8
255	R:R:L356	R:R:Y360	2.34	No	No	0	2	3
256	R:R:E182	R:R:R252	2.33	No	No	0	2	4
257	R:R:G258	R:R:G259	2.11	No	No	0	3	4
258	R:R:G164	R:R:P166	2.03	No	No	0	6	8
259	R:R:C120	R:R:G117	1.96	Yes	No	0	6	3
260	R:R:C374	R:R:G123	1.96	No	No	0	8	8
261	R:R:A260	R:R:P257	1.87	No	No	0	1	3
262	R:R:A309	R:R:P310	1.87	No	No	0	4	3
263	R:R:A339	R:R:P340	1.87	No	No	0	5	9
264	R:R:A365	R:R:P340	1.87	No	No	0	6	9
265	R:R:A251	R:R:C185	1.81	No	No	10	4	9
266	R:R:A251	R:R:C263	1.81	No	No	10	4	9
267	R:R:P255	R:R:V261	1.77	No	No	0	2	4
268	R:R:G126	R:R:I125	1.76	No	No	0	7	4
269	L:L:M4	R:R:G176	1.75	No	No	0	0	4
270	R:R:G174	R:R:M173	1.75	No	No	0	4	5
271	L:L:G10	L:L:L9	1.71	No	Yes	0	0	0
272	R:R:G123	R:R:L122	1.71	No	No	0	8	5
273	R:R:G123	R:R:L162	1.71	No	No	0	8	7
274	R:R:G262	R:R:L253	1.71	No	No	0	5	5
275	R:R:A309	R:R:S306	1.71	No	No	0	4	4
276	R:R:A364	R:R:S367	1.71	No	No	0	5	5
277	R:R:I149	R:R:P226	1.69	No	No	0	6	1
278	R:R:A251	R:R:T186	1.68	No	No	0	4	6
279	R:R:C120	R:R:I124	1.64	Yes	No	0	6	6
280	R:R:A229	R:R:I149	1.62	No	No	0	7	6
281	R:R:A190	R:R:I244	1.62	No	Yes	0	5	7
282	R:R:D271	R:R:P270	1.61	No	No	0	2	3
283	R:R:S128	R:R:T129	1.6	No	No	0	3	5
284	R:R:V291	R:R:V292	1.6	No	Yes	0	4	6
285	R:R:A327	R:R:L301	1.58	No	No	0	8	5
286	R:R:P310	R:R:Q313	1.58	No	No	0	3	4
287	R:R:C143	R:R:N144	1.57	Yes	No	0	8	4
288	R:R:T355	R:R:T357	1.57	No	No	0	1	3
289	R:R:I111	R:R:V115	1.54	No	No	0	6	5
290	R:R:I131	R:R:V135	1.54	Yes	No	0	7	3
291	R:R:I131	R:R:V156	1.54	Yes	No	0	7	6
292	R:R:H216	R:R:P217	1.53	No	No	0	6	8
293	R:R:K136	R:R:V135	1.52	No	No	0	5	3
294	R:R:I316	R:R:T320	1.52	No	No	0	4	7
295	R:R:I328	R:R:T324	1.52	No	No	0	5	6
296	R:R:F180	R:R:G181	1.51	Yes	No	0	6	7
297	R:R:L160	R:R:S195	1.5	No	No	0	6	8
298	R:R:K222	R:R:T221	1.5	No	No	0	3	5
299	R:R:L349	R:R:S350	1.5	No	No	0	5	4
300	R:R:L344	R:R:V343	1.49	Yes	No	0	4	6
301	R:R:N175	R:R:V177	1.48	No	No	0	4	5
302	R:R:L122	R:R:T118	1.47	No	No	0	5	5
303	R:R:L391	R:R:T129	1.47	No	No	0	6	5
304	R:R:L346	R:R:T278	1.47	No	No	0	6	5
305	R:R:L361	R:R:T357	1.47	No	No	0	5	3
306	R:R:F277	R:R:P246	1.44	Yes	No	0	5	8
307	R:R:P354	R:R:R353	1.44	No	No	0	1	2
308	R:R:E182	R:R:T183	1.41	No	No	0	2	3
309	R:R:L279	R:R:L346	1.38	No	No	0	4	6
310	R:R:L344	R:R:L361	1.38	Yes	No	0	4	5
311	R:R:I351	R:R:Q348	1.37	No	Yes	0	3	3
312	R:R:R353	R:R:S352	1.32	No	No	0	2	1
313	R:R:F335	R:R:V336	1.31	Yes	No	0	6	6
314	R:R:R388	R:R:V382	1.31	No	No	0	8	7
315	R:R:K389	R:R:R390	1.24	No	Yes	0	5	5
316	R:R:L318	R:R:R314	1.21	No	No	0	4	4
317	R:R:L239	R:R:Y201	1.17	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L9	4.235	6	1	0
2	R:R:F116	5.525	6	1	7
3	R:R:C120	2.9075	4	0	6
4	R:R:N127	5.44	4	6	9
5	R:R:I131	2.28	4	0	7
6	R:R:C143	3.6	4	7	8
7	R:R:V146	3.48	4	0	6
8	R:R:F150	3.595	4	0	7
9	R:R:S155	3.5075	4	0	9
10	R:R:D158	5.412	5	6	9
11	R:R:F161	7.11333	6	1	7
12	R:R:M165	7.924	5	1	7
13	R:R:F180	7.5225	4	9	6
14	R:R:Q196	8.2075	4	1	8
15	R:R:F197	7.315	4	5	6
16	R:R:Y201	3.438	5	5	6
17	R:R:T204	4.005	4	2	7
18	R:R:Y211	4.028	5	0	8
19	R:R:W237	5.9475	4	8	9
20	R:R:S243	5.3	4	5	5
21	R:R:I244	5.70833	6	5	7
22	R:R:Y250	5.26	4	3	5
23	R:R:I254	4.7875	4	4	2
24	R:R:R266	10.0525	4	4	3
25	R:R:D273	10.6	4	3	2
26	R:R:F277	6.4	4	3	5
27	R:R:V292	2.705	4	2	6
28	R:R:I293	4.335	4	2	8
29	R:R:Y297	4.68	7	2	9
30	R:R:F334	5.3975	4	1	9
31	R:R:F335	6.08	4	0	6
32	R:R:W338	8.174	5	1	8
33	R:R:Y341	6.5775	4	1	7
34	R:R:Y342	6.715	4	0	8
35	R:R:L344	2.9775	4	0	4
36	R:R:Q345	5.265	6	1	5
37	R:R:Q348	5.96833	6	1	3
38	R:R:Y362	5.372	5	1	3
39	R:R:Y370	6.63	5	1	7
40	R:R:L383	4.35	4	0	7
41	R:R:F387	5.81	5	0	8
42	R:R:R390	6.0925	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N363	R:R:V359	12.9795	2.96	No	No	0	4	3
2	R:R:L172	R:R:N363	14.5533	13.73	No	No	0	4	4
3	L:L:Y13	R:R:L172	16.002	3.52	No	No	0	0	4
4	L:L:M8	L:L:Y13	17.5713	4.79	No	No	0	0	0
5	L:L:M8	R:R:Y362	19.0334	4.79	No	Yes	0	0	3
6	R:R:Q348	R:R:Y362	49.4903	7.89	Yes	Yes	1	3	3
7	L:L:R14	R:R:Q348	18.5639	9.35	No	Yes	1	0	3
8	L:L:C7	L:L:R14	23.6922	8.36	No	No	0	0	0
9	L:L:C16	L:L:C7	21.3628	7.28	No	No	0	0	0
10	L:L:C16	R:R:F256	19.0244	11.17	No	No	0	0	1
11	L:L:L9	R:R:I265	87.4676	4.28	Yes	No	0	0	4
12	L:L:L9	R:R:Q345	69.9723	3.99	Yes	Yes	1	0	5
13	R:R:Q345	R:R:Q348	10.0823	3.84	Yes	Yes	1	5	3
14	R:R:Q345	R:R:Y341	66.7308	6.76	Yes	Yes	1	5	7
15	R:R:Y341	R:R:Y342	78.2751	10.92	Yes	Yes	0	7	8
16	R:R:Q196	R:R:Y342	80.1529	3.38	Yes	Yes	0	8	8
17	L:L:R11	R:R:Q196	14.0392	9.35	No	Yes	1	0	8
18	R:R:Y341	R:R:Y362	14.5668	5.96	Yes	Yes	1	7	3
19	R:R:I366	R:R:Y362	84.7849	4.84	No	Yes	1	5	3
20	R:R:I366	R:R:Y370	68.1525	3.63	No	Yes	1	5	7
21	R:R:F161	R:R:Y370	68.2151	6.19	Yes	Yes	1	7	7
22	R:R:D192	R:R:F161	27.828	8.36	No	Yes	1	6	7
23	L:L:V12	R:R:I265	85.2499	6.14	No	No	0	0	4
24	L:L:V12	R:R:Q171	47.6616	8.6	No	No	0	0	5
25	L:L:V12	R:R:G264	37.4899	3.68	No	No	0	0	3
26	R:R:G264	R:R:I254	34.8699	3.53	No	Yes	0	3	2
27	R:R:I254	R:R:R266	10.8692	3.76	Yes	Yes	4	2	3
28	R:R:F116	R:R:I366	17.0929	3.77	Yes	No	1	7	5
29	R:R:F116	R:R:M165	11.7097	3.73	Yes	Yes	1	7	7
30	R:R:M165	R:R:Y370	14.7054	15.57	Yes	Yes	1	7	7
31	R:R:C120	R:R:M165	21.5148	4.86	Yes	Yes	0	6	7
32	R:R:C120	R:R:L162	18.926	3.17	Yes	No	0	6	7
33	R:R:G123	R:R:L162	34.0472	1.71	No	No	0	8	7
34	R:R:F161	R:R:S373	100	7.93	Yes	No	0	7	9
35	R:R:L162	R:R:S373	24.2735	3	No	No	0	7	9
36	R:R:G123	R:R:L122	22.7622	1.71	No	No	0	8	5
37	R:R:F378	R:R:L122	17.0661	3.65	No	No	0	6	5
38	R:R:F378	R:R:G126	14.2046	3.01	No	No	0	6	7
39	R:R:G126	R:R:I125	11.3342	1.76	No	No	0	7	4
40	R:R:D158	R:R:S373	86.8461	5.89	Yes	No	0	9	9
41	R:R:D158	R:R:N127	72.8517	5.39	Yes	Yes	6	9	9
42	R:R:N127	R:R:S155	69.1407	2.98	Yes	Yes	0	9	9
43	R:R:S155	R:R:V130	29.0307	4.85	Yes	No	0	9	9
44	R:R:I381	R:R:V130	27.4792	3.07	No	No	0	7	9
45	R:R:I131	R:R:S155	12.2642	3.1	Yes	Yes	0	7	9
46	R:R:F387	R:R:I381	25.9277	7.54	Yes	No	0	8	7
47	R:R:I151	R:R:S155	28.7222	3.1	No	Yes	0	8	9
48	R:R:I151	R:R:Y380	27.1484	13.3	No	No	0	8	9
49	R:R:F387	R:R:Y380	25.6818	11.35	Yes	No	0	8	9
50	R:R:F387	R:R:R390	42.1756	3.21	Yes	Yes	0	8	5
51	R:R:K137	R:R:R390	19.6191	17.33	No	Yes	0	5	5
52	R:R:D148	R:R:K137	16.4446	5.53	No	No	0	8	5
53	R:R:Q196	R:R:W338	94.7912	14.24	Yes	Yes	1	8	8
54	R:R:F334	R:R:W338	84.7894	4.01	Yes	Yes	1	9	8
55	R:R:F334	R:R:L203	86.4079	3.65	Yes	No	0	9	8
56	R:R:I293	R:R:L203	85.3841	4.28	Yes	No	0	8	8
57	R:R:I293	R:R:Y297	74.4076	3.63	Yes	Yes	2	8	9
58	R:R:R210	R:R:Y297	22.9098	5.14	No	Yes	0	9	9
59	R:R:M206	R:R:R210	21.5416	13.65	No	No	0	9	9
60	R:R:F150	R:R:M206	20.0528	4.98	Yes	No	0	7	9
61	R:R:F150	R:R:V146	15.6398	2.62	Yes	Yes	0	7	6
62	R:R:D158	R:R:S199	15.4699	4.42	Yes	No	0	9	9
63	R:R:S199	R:R:V157	13.9542	3.23	No	No	0	9	8
64	R:R:Q171	R:R:W178	29.603	10.95	No	No	0	5	8
65	R:R:F180	R:R:W178	16.1719	12.03	Yes	No	9	6	8
66	R:R:F167	R:R:F180	10.8871	7.5	No	Yes	0	6	6
67	R:R:D192	R:R:M168	38.8357	9.7	No	No	0	6	6
68	R:R:M168	R:R:T189	36.8059	3.01	No	No	0	6	5
69	R:R:H170	R:R:W178	10.7798	11.64	No	No	9	4	8
70	R:R:C263	R:R:Q171	16.2747	4.58	No	No	0	9	5
71	R:R:A251	R:R:C263	10.8692	1.81	No	No	10	4	9
72	R:R:T189	R:R:V247	34.7805	4.76	No	No	0	5	5
73	R:R:I244	R:R:V247	32.6165	4.61	Yes	No	0	7	5
74	R:R:F197	R:R:I244	14.4594	11.3	Yes	Yes	5	6	7
75	R:R:I244	R:R:S243	10.8245	6.19	Yes	Yes	5	7	5
76	R:R:S243	R:R:Y201	10.2298	3.82	Yes	Yes	5	5	6
77	R:R:I293	R:R:T204	12.5861	4.56	Yes	Yes	2	8	7
78	R:R:I300	R:R:Y297	24.6043	2.42	No	Yes	0	8	9
79	R:R:I300	R:R:Y211	21.6534	2.42	No	Yes	0	8	8
80	R:R:Q281	R:R:Q345	25.7623	5.12	No	Yes	0	5	5
81	R:R:F277	R:R:Q281	23.8085	14.05	Yes	No	0	5	5
82	R:R:I254	R:R:P255	18.9618	3.39	Yes	No	0	2	2
83	R:R:P255	R:R:V261	16.2792	1.77	No	No	0	2	4
84	R:R:L253	R:R:V261	13.5876	10.43	No	No	0	5	4
85	R:R:Q345	R:R:T278	11.6829	8.5	Yes	No	0	5	5
86	R:R:A327	R:R:Y297	21.5506	4	No	Yes	0	8	9
87	R:R:I330	R:R:Y297	12.4922	10.88	No	Yes	0	8	9
88	R:R:A327	R:R:L301	20.0528	1.58	No	No	0	8	5
89	R:R:L301	R:R:V323	15.528	4.47	No	No	0	5	7
90	R:R:M304	R:R:V323	14.1107	7.61	No	No	0	8	7
91	R:R:M304	R:R:T320	12.5771	4.52	No	No	0	8	7
92	R:R:I316	R:R:T320	11.0391	1.52	No	No	0	4	7
93	R:R:R390	R:R:T386	16.3418	2.59	Yes	No	0	5	6
94	R:R:E385	R:R:T386	13.0466	8.47	No	No	0	5	6
95	R:R:I330	R:R:T326	10.9631	3.04	No	No	0	8	8
96	R:R:F358	R:R:Q348	13.2344	9.37	No	Yes	0	4	3
97	R:R:F358	R:R:L344	11.3699	6.09	No	Yes	0	4	4
98	R:R:Q345	R:R:Y362	40.8835	3.38	Yes	Yes	1	5	3
99	L:L:L9	R:R:Q348	28.1901	3.99	Yes	Yes	1	0	3
100	R:R:F161	R:R:Q196	72.5923	5.86	Yes	Yes	1	7	8
101	L:L:R11	R:R:D192	13.2388	9.53	No	No	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:M4	R:R:P257	3.35	0	No	No	0	3	0	1
L:L:L5	R:R:V359	4.47	0	No	No	0	3	0	1
L:L:R6	R:R:F256	6.41	0	No	No	0	1	0	1
L:L:M8	R:R:Y362	4.79	0	No	Yes	0	3	0	1
L:L:L9	R:R:I265	4.28	1	Yes	No	0	4	0	1
L:L:L9	R:R:L274	4.15	1	Yes	No	0	5	0	1
L:L:L9	R:R:Q345	3.99	1	Yes	Yes	0	5	0	1
L:L:L9	R:R:Q348	3.99	1	Yes	Yes	0	3	0	1
L:L:R11	R:R:F161	6.41	1	No	Yes	0	7	0	1
L:L:R11	R:R:D192	9.53	1	No	No	0	6	0	1
L:L:R11	R:R:Q196	9.35	1	No	Yes	0	8	0	1
L:L:V12	R:R:Q171	8.6	0	No	No	0	5	0	1
L:L:V12	R:R:G264	3.68	0	No	No	0	3	0	1
L:L:V12	R:R:I265	6.14	0	No	No	0	4	0	1
L:L:Y13	R:R:L172	3.52	0	No	No	0	4	0	1
L:L:R14	R:R:Q348	9.35	1	No	Yes	0	3	0	1
L:L:P15	R:R:I254	8.47	4	No	Yes	0	2	0	1
L:L:P15	R:R:R266	12.97	4	No	Yes	0	3	0	1
L:L:C16	R:R:F256	11.17	0	No	No	0	1	0	1
L:L:W17	R:R:R353	13	0	No	No	0	2	0	1
L:L:Q18	R:R:R266	10.51	4	No	Yes	0	3	0	1
L:L:Q18	R:R:P270	3.16	4	No	No	0	3	0	1
R:R:D192	R:R:F161	8.36	1	No	Yes	6	7	1	1
R:R:F161	R:R:S195	7.93	1	Yes	No	7	8	1	2
R:R:F161	R:R:Q196	5.86	1	Yes	Yes	7	8	1	1
R:R:F161	R:R:Y370	6.19	1	Yes	Yes	7	7	1	2
R:R:F161	R:R:S373	7.93	1	Yes	No	7	9	1	2
R:R:D192	R:R:M168	9.7	1	No	No	6	6	1	2
R:R:Q171	R:R:W178	10.95	0	No	No	5	8	1	2
R:R:C263	R:R:Q171	4.58	10	No	No	9	5	2	1
R:R:L172	R:R:N363	13.73	0	No	No	4	4	1	2
R:R:Q196	R:R:W338	14.24	1	Yes	Yes	8	8	1	2
R:R:Q196	R:R:Y342	3.38	1	Yes	Yes	8	8	1	2
R:R:I254	R:R:P255	3.39	4	Yes	No	2	2	1	2
R:R:G264	R:R:I254	3.53	0	No	Yes	3	2	1	1
R:R:I254	R:R:R266	3.76	4	Yes	Yes	2	3	1	1
R:R:F256	R:R:P257	4.33	0	No	No	1	3	1	1
R:R:P270	R:R:R266	12.97	4	No	Yes	3	3	1	1
R:R:L274	R:R:L349	6.92	0	No	No	5	5	1	2
R:R:Q345	R:R:T278	8.5	1	Yes	No	5	5	1	2
R:R:L349	R:R:T278	4.42	0	No	No	5	5	2	2
R:R:Q281	R:R:Q345	5.12	0	No	Yes	5	5	2	1
R:R:Y341	R:R:Y342	10.92	1	Yes	Yes	7	8	2	2
R:R:Q345	R:R:Y341	6.76	1	Yes	Yes	5	7	1	2
R:R:Y341	R:R:Y362	5.96	1	Yes	Yes	7	3	2	1
R:R:Q345	R:R:Q348	3.84	1	Yes	Yes	5	3	1	1
R:R:Q345	R:R:Y362	3.38	1	Yes	Yes	5	3	1	1
R:R:F358	R:R:Q348	9.37	0	No	Yes	4	3	2	1
R:R:Q348	R:R:Y362	7.89	1	Yes	Yes	3	3	1	1
R:R:P354	R:R:V359	3.53	0	No	No	1	3	2	1
R:R:I366	R:R:Y362	4.84	1	No	Yes	5	3	2	1
R:R:I366	R:R:Y370	3.63	1	No	Yes	5	7	2	2
R:R:N363	R:R:V359	2.96	0	No	No	4	3	2	1
L:L:L5	R:R:L356	2.77	0	No	No	0	2	0	1
R:R:L356	R:R:Y360	2.34	0	No	No	2	3	1	2
R:R:A260	R:R:P257	1.87	0	No	No	1	3	2	1
L:L:M4	R:R:G176	1.75	0	No	No	0	4	0	1
R:R:D271	R:R:P270	1.61	0	No	No	2	3	2	1
R:R:P354	R:R:R353	1.44	0	No	No	1	2	2	1
R:R:I351	R:R:Q348	1.37	0	No	Yes	3	3	2	1
R:R:R353	R:R:S352	1.32	0	No	No	2	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WSS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	281
Number of Links	317
Number of Hubs	42
Number of Links mediated by Hubs	159
Number of Communities	10
Number of Nodes involved in Communities	55
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	65344
Length Of Smallest Path	3
Average Path Length	14.4452
Length of Longest Path	29
Minimum Path Strength	1.38
Average Path Strength	5.66796
Maximum Path Strength	14.875
Minimum Path Correlation	0.7
Average Path Correlation	0.933734
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.9926
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.7502
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • melanin-concentrating hormone receptor binding • signaling receptor binding • type 1 melanin-concentrating hormone receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • melanin-concentrating hormone activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide signaling pathway • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission, dopaminergic • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • trans-synaptic signaling • regulation of signaling • regulation of synaptic transmission, dopaminergic • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • synaptic transmission, dopaminergic • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • behavior • feeding behavior • neuropeptide binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • melanin-concentrating hormone receptor activity • protein-hormone receptor activity • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • metabolic process • generation of precursor metabolites and energy • ciliary membrane • plasma membrane region • cell projection membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99705
Sequence	>8WSS_nogp_Chain_R Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S C N N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G N G V W H F G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H P I S S T K F R K P S V A T L V I C L L W A L S F I S I T P V W L Y A R L I P F P G G A V G C G I R L P N P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M T S S V A P A S Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I S R P T L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T F R K R L V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	To be published
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	To be published
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	To be published
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	To be published
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	To be published
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	To be published
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	To be published
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	10.1038/s41421-024-00679-8
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	10.1038/s41421-024-00754-0
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	10.1038/s41421-024-00754-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WSS_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.