psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:F2	17.91	No	No	0	0	0
2	L:L:M4	L:L:R6	11.17	No	No	0	0	0
3	L:L:M4	R:R:P188	3.35	No	No	0	0	3
4	L:L:L5	R:R:V290	4.47	No	No	0	0	3
5	L:L:R6	R:R:F187	6.41	No	No	0	0	1
6	L:L:C7	L:L:R14	8.36	No	No	0	0	0
7	L:L:C16	L:L:C7	7.28	No	No	0	0	0
8	L:L:M8	L:L:Y13	4.79	No	No	0	0	0
9	L:L:M8	R:R:Y293	4.79	No	Yes	0	0	3
10	L:L:L9	L:L:R14	7.29	Yes	No	1	0	0
11	L:L:L9	R:R:I196	4.28	Yes	No	0	0	4
12	L:L:L9	R:R:L205	4.15	Yes	No	0	0	5
13	L:L:L9	R:R:Q276	3.99	Yes	Yes	1	0	5
14	L:L:L9	R:R:Q279	3.99	Yes	Yes	1	0	3
15	L:L:R11	R:R:F92	6.41	No	Yes	1	0	7
16	L:L:R11	R:R:D123	9.53	No	No	1	0	6
17	L:L:R11	R:R:Q127	9.35	No	Yes	1	0	8
18	L:L:V12	R:R:Q102	8.6	No	No	0	0	5
19	L:L:V12	R:R:G195	3.68	No	No	0	0	3
20	L:L:V12	R:R:I196	6.14	No	No	0	0	4
21	L:L:Y13	R:R:L103	3.52	No	No	0	0	4
22	L:L:R14	R:R:Q279	9.35	No	Yes	1	0	3
23	L:L:P15	R:R:I185	8.47	No	Yes	4	0	2
24	L:L:P15	R:R:R197	12.97	No	Yes	4	0	3
25	L:L:C16	R:R:F187	11.17	No	No	0	0	1
26	L:L:W17	R:R:R284	13	No	No	0	0	2
27	L:L:Q18	R:R:R197	10.51	No	Yes	4	0	3
28	L:L:Q18	R:R:P201	3.16	No	No	4	0	3
29	R:R:I39	R:R:Y38	7.25	No	No	0	3	4
30	R:R:N40	R:R:Y38	6.98	No	No	0	4	4
31	R:R:I41	R:R:N40	4.25	No	No	0	4	4
32	R:R:M43	R:R:P44	6.71	No	No	0	5	5
33	R:R:M104	R:R:P44	6.71	No	No	0	5	5
34	R:R:F47	R:R:M96	3.73	Yes	Yes	1	7	7
35	R:R:F47	R:R:I100	15.07	Yes	No	1	7	6
36	R:R:F47	R:R:I297	3.77	Yes	No	1	7	5
37	R:R:F47	R:R:S298	3.96	Yes	No	0	7	5
38	R:R:F47	R:R:Y301	4.13	Yes	Yes	1	7	7
39	R:R:A302	R:R:I50	4.87	No	No	0	5	7
40	R:R:C305	R:R:I50	3.27	No	No	0	8	7
41	R:R:C51	R:R:L93	3.17	Yes	No	0	6	7
42	R:R:C51	R:R:M96	4.86	Yes	Yes	0	6	7
43	R:R:F309	R:R:L53	3.65	No	No	0	6	5
44	R:R:I56	R:R:S59	3.1	No	No	0	4	3
45	R:R:F309	R:R:G57	3.01	No	No	0	6	7
46	R:R:N58	R:R:S86	2.98	Yes	Yes	0	9	9
47	R:R:D89	R:R:N58	5.39	Yes	Yes	6	9	9
48	R:R:L90	R:R:N58	6.87	No	Yes	0	8	9
49	R:R:N58	R:R:P308	6.52	Yes	No	6	9	9
50	R:R:S86	R:R:V61	4.85	Yes	No	0	9	9
51	R:R:I312	R:R:V61	3.07	No	No	0	7	9
52	R:R:I62	R:R:S86	3.1	Yes	Yes	0	7	9
53	R:R:F63	R:R:K67	12.41	No	No	0	3	5
54	R:R:A64	R:R:F318	4.16	No	Yes	0	7	8
55	R:R:I83	R:R:V65	7.68	No	No	0	6	7
56	R:R:D79	R:R:K68	5.53	No	No	0	8	5
57	R:R:K68	R:R:R321	17.33	No	Yes	0	5	5
58	R:R:C74	R:R:S69	3.44	Yes	No	0	8	6
59	R:R:C74	R:R:N76	4.72	Yes	No	7	8	8
60	R:R:C74	R:R:D79	4.67	Yes	No	7	8	8
61	R:R:D79	R:R:N76	9.42	No	No	7	8	8
62	R:R:P78	R:R:V77	3.53	No	Yes	0	8	6
63	R:R:D140	R:R:V77	4.38	No	Yes	0	8	6
64	R:R:A160	R:R:V77	3.39	No	Yes	0	7	6
65	R:R:A136	R:R:F81	4.16	No	Yes	0	7	7
66	R:R:F81	R:R:M137	4.98	Yes	No	0	7	9
67	R:R:I82	R:R:S86	3.1	No	Yes	0	8	9
68	R:R:I82	R:R:Y311	13.3	No	No	0	8	9
69	R:R:I133	R:R:N84	8.5	No	No	0	8	9
70	R:R:I164	R:R:N84	8.5	No	No	0	7	9
71	R:R:N84	R:R:W168	9.04	No	Yes	0	9	9
72	R:R:D89	R:R:L85	8.14	Yes	No	0	9	9
73	R:R:I133	R:R:L85	5.71	No	No	0	8	9
74	R:R:L85	R:R:N307	5.49	No	No	0	9	9
75	R:R:T129	R:R:V88	6.35	No	No	8	7	8
76	R:R:S130	R:R:V88	3.23	No	No	0	9	8
77	R:R:V88	R:R:W168	3.68	No	Yes	8	8	9
78	R:R:D89	R:R:S130	4.42	Yes	No	0	9	9
79	R:R:D89	R:R:S304	5.89	Yes	No	0	9	9
80	R:R:D89	R:R:P308	3.22	Yes	No	6	9	9
81	R:R:D123	R:R:F92	8.36	No	Yes	1	6	7
82	R:R:F92	R:R:S126	7.93	Yes	No	0	7	8
83	R:R:F92	R:R:Q127	5.86	Yes	Yes	1	7	8
84	R:R:F92	R:R:Y301	6.19	Yes	Yes	1	7	7
85	R:R:F92	R:R:S304	7.93	Yes	No	0	7	9
86	R:R:L93	R:R:S304	3	No	No	0	7	9
87	R:R:M96	R:R:P97	6.71	Yes	No	0	7	8
88	R:R:I100	R:R:M96	8.75	No	Yes	1	6	7
89	R:R:M96	R:R:Y301	15.57	Yes	Yes	1	7	7
90	R:R:F111	R:R:F98	7.5	Yes	No	0	6	6
91	R:R:F98	R:R:I119	10.05	No	No	0	6	5
92	R:R:M99	R:R:T120	3.01	No	No	0	6	5
93	R:R:D123	R:R:M99	9.7	No	No	0	6	6
94	R:R:I100	R:R:Y301	3.63	No	Yes	1	6	7
95	R:R:H101	R:R:W109	11.64	No	No	9	4	8
96	R:R:H101	R:R:H110	3.58	No	No	0	4	2
97	R:R:F111	R:R:H101	9.05	Yes	No	9	6	4
98	R:R:Q102	R:R:W109	10.95	No	No	0	5	8
99	R:R:C194	R:R:Q102	4.58	No	No	0	9	5
100	R:R:L103	R:R:N294	13.73	No	No	0	4	4
101	R:R:H110	R:R:V108	5.54	No	No	0	2	5
102	R:R:F111	R:R:W109	12.03	Yes	No	9	6	8
103	R:R:L118	R:R:M115	4.24	No	No	0	4	6
104	R:R:I119	R:R:M115	5.83	No	No	0	5	6
105	R:R:C116	R:R:C194	7.28	No	No	10	9	9
106	R:R:T117	R:R:W179	3.64	No	No	0	6	4
107	R:R:T120	R:R:V178	4.76	No	No	0	5	5
108	R:R:A124	R:R:I175	4.87	No	Yes	0	4	7
109	R:R:N125	R:R:S171	10.43	No	No	0	5	8
110	R:R:F172	R:R:N125	10.87	No	No	0	4	5
111	R:R:I175	R:R:N125	5.66	Yes	No	0	7	5
112	R:R:Q127	R:R:W269	14.24	Yes	Yes	1	8	8
113	R:R:Q127	R:R:Y273	3.38	Yes	Yes	0	8	8
114	R:R:F128	R:R:Y132	5.16	Yes	Yes	5	6	6
115	R:R:F128	R:R:S174	7.93	Yes	Yes	5	6	5
116	R:R:F128	R:R:I175	11.3	Yes	Yes	5	6	7
117	R:R:F128	R:R:L215	4.87	Yes	No	5	6	4
118	R:R:T129	R:R:W168	6.06	No	Yes	8	7	9
119	R:R:S171	R:R:T129	4.8	No	No	0	8	7
120	R:R:P220	R:R:T131	3.5	No	No	0	9	8
121	R:R:L167	R:R:Y132	3.52	No	Yes	0	7	6
122	R:R:S174	R:R:Y132	3.82	Yes	Yes	5	5	6
123	R:R:L215	R:R:Y132	3.52	No	Yes	5	4	6
124	R:R:I224	R:R:L134	4.28	Yes	No	0	8	8
125	R:R:F265	R:R:L134	3.65	Yes	No	0	9	8
126	R:R:I139	R:R:T135	3.04	No	Yes	2	6	7
127	R:R:P220	R:R:T135	5.25	No	Yes	0	9	7
128	R:R:T135	R:R:V223	3.17	Yes	Yes	2	7	6
129	R:R:I224	R:R:T135	4.56	Yes	Yes	2	8	7
130	R:R:M137	R:R:R141	13.65	No	No	0	9	9
131	R:R:A138	R:R:I224	4.87	No	Yes	2	9	8
132	R:R:A138	R:R:Y228	4	No	Yes	2	9	9
133	R:R:I139	R:R:V223	3.07	No	Yes	2	6	6
134	R:R:D140	R:R:R155	8.34	No	No	0	8	6
135	R:R:R141	R:R:Y228	5.14	No	Yes	0	9	9
136	R:R:V146	R:R:Y142	7.57	No	Yes	0	7	8
137	R:R:R230	R:R:Y142	5.14	No	Yes	0	4	8
138	R:R:F154	R:R:L143	3.65	No	No	0	4	4
139	R:R:A144	R:R:R155	4.15	No	No	0	8	6
140	R:R:I231	R:R:T145	13.68	No	No	0	8	9
141	R:R:H147	R:R:V146	8.3	No	No	0	6	7
142	R:R:R234	R:R:V146	6.54	No	No	0	6	7
143	R:R:R155	R:R:S151	5.27	No	No	0	6	6
144	R:R:K156	R:R:P157	3.35	No	No	0	7	1
145	R:R:F172	R:R:W168	5.01	No	Yes	0	4	9
146	R:R:S171	R:R:S174	3.26	No	Yes	0	8	5
147	R:R:I175	R:R:S174	6.19	Yes	Yes	5	7	5
148	R:R:I175	R:R:V178	4.61	Yes	No	0	7	5
149	R:R:P177	R:R:T176	3.5	No	No	0	8	4
150	R:R:L180	R:R:W179	3.42	No	No	0	5	4
151	R:R:L198	R:R:Y181	7.03	No	Yes	0	5	5
152	R:R:P199	R:R:Y181	4.17	No	Yes	3	4	5
153	R:R:W207	R:R:Y181	6.75	No	Yes	3	5	5
154	R:R:F208	R:R:Y181	3.09	Yes	Yes	3	5	5
155	R:R:L184	R:R:V192	10.43	No	No	0	5	4
156	R:R:I185	R:R:P186	3.39	Yes	No	0	2	2
157	R:R:G195	R:R:I185	3.53	No	Yes	0	3	2
158	R:R:I185	R:R:R197	3.76	Yes	Yes	4	2	3
159	R:R:F187	R:R:P188	4.33	No	No	0	1	3
160	R:R:P201	R:R:R197	12.97	No	Yes	4	3	3
161	R:R:D204	R:R:L198	16.29	Yes	No	0	2	5
162	R:R:N200	R:R:P199	3.26	No	No	3	4	4
163	R:R:D204	R:R:P199	4.83	Yes	No	3	2	4
164	R:R:N200	R:R:T203	7.31	No	No	0	4	3
165	R:R:D204	R:R:N200	13.46	Yes	No	3	2	4
166	R:R:D204	R:R:W207	7.82	Yes	No	3	2	5
167	R:R:L205	R:R:L280	6.92	No	No	0	5	5
168	R:R:L210	R:R:Y206	10.55	No	No	0	4	3
169	R:R:F208	R:R:W207	7.02	Yes	No	3	5	5
170	R:R:F208	R:R:Q212	14.05	Yes	No	0	5	5
171	R:R:Q276	R:R:T209	8.5	Yes	No	0	5	5
172	R:R:L280	R:R:T209	4.42	No	No	0	5	5
173	R:R:L215	R:R:Y211	5.86	No	No	0	4	3
174	R:R:Q212	R:R:Q276	5.12	No	Yes	0	5	5
175	R:R:F213	R:R:Y273	7.22	No	Yes	0	5	8
176	R:R:A218	R:R:F214	4.16	No	No	0	5	4
177	R:R:A216	R:R:Y273	5.34	No	Yes	0	5	8
178	R:R:F217	R:R:F265	6.43	No	Yes	1	8	9
179	R:R:F217	R:R:F266	6.43	No	Yes	0	8	6
180	R:R:F217	R:R:W269	4.01	No	Yes	1	8	8
181	R:R:L219	R:R:P220	4.93	No	No	0	5	9
182	R:R:L219	R:R:V223	2.98	No	Yes	0	5	6
183	R:R:F221	R:R:T225	7.78	No	No	0	6	5
184	R:R:F221	R:R:F265	7.5	No	Yes	0	6	9
185	R:R:F221	R:R:F266	9.65	No	Yes	0	6	6
186	R:R:I224	R:R:Y228	3.63	Yes	Yes	2	8	9
187	R:R:A258	R:R:Y228	4	No	Yes	0	8	9
188	R:R:I261	R:R:Y228	10.88	No	Yes	0	8	9
189	R:R:Q233	R:R:V229	5.73	No	No	0	3	4
190	R:R:Q233	R:R:R230	5.84	No	No	0	3	4
191	R:R:R230	R:R:R234	7.46	No	No	0	4	6
192	R:R:L232	R:R:V254	4.47	No	No	0	5	7
193	R:R:L232	R:R:T255	4.42	No	No	0	5	6
194	R:R:M235	R:R:T251	4.52	No	No	0	8	7
195	R:R:M235	R:R:V254	7.61	No	No	0	8	7
196	R:R:I247	R:R:P241	6.77	No	No	0	4	3
197	R:R:R248	R:R:S243	3.95	No	No	0	4	2
198	R:R:I247	R:R:R250	6.26	No	No	0	4	6
199	R:R:L249	R:R:R253	3.64	No	No	0	4	7
200	R:R:E316	R:R:R253	3.49	No	No	0	5	7
201	R:R:I261	R:R:T257	3.04	No	No	0	8	8
202	R:R:L314	R:R:T257	8.84	Yes	No	0	7	8
203	R:R:A260	R:R:L314	3.15	No	Yes	0	6	7
204	R:R:L263	R:R:V267	2.98	No	No	0	5	6
205	R:R:N303	R:R:V264	4.43	No	No	0	9	6
206	R:R:L306	R:R:V264	2.98	No	No	0	6	6
207	R:R:V264	R:R:V310	4.81	No	No	0	6	8
208	R:R:F265	R:R:W269	4.01	Yes	Yes	1	9	8
209	R:R:A270	R:R:F266	6.93	No	Yes	0	5	6
210	R:R:C268	R:R:N303	9.45	No	No	0	8	9
211	R:R:G300	R:R:W269	8.44	No	Yes	0	7	8
212	R:R:N303	R:R:W269	10.17	No	Yes	0	9	8
213	R:R:L299	R:R:P271	3.28	No	No	0	8	9
214	R:R:Y272	R:R:Y273	10.92	Yes	Yes	0	7	8
215	R:R:Q276	R:R:Y272	6.76	Yes	Yes	1	5	7
216	R:R:Y272	R:R:Y293	5.96	Yes	Yes	1	7	3
217	R:R:F289	R:R:L275	6.09	No	Yes	0	4	4
218	R:R:Q276	R:R:Q279	3.84	Yes	Yes	1	5	3
219	R:R:Q276	R:R:Y293	3.38	Yes	Yes	1	5	3
220	R:R:F289	R:R:Q279	9.37	No	Yes	0	4	3
221	R:R:Q279	R:R:Y293	7.89	Yes	Yes	1	3	3
222	R:R:P285	R:R:V290	3.53	No	No	0	1	3
223	R:R:I297	R:R:Y293	4.84	No	Yes	1	5	3
224	R:R:I297	R:R:Y301	3.63	No	Yes	1	5	7
225	R:R:N307	R:R:P308	4.89	No	No	0	9	9
226	R:R:F318	R:R:Y311	11.35	Yes	No	0	8	9
227	R:R:F318	R:R:I312	7.54	Yes	No	0	8	7
228	R:R:L314	R:R:V313	2.98	Yes	No	0	7	7
229	R:R:E316	R:R:T317	8.47	No	No	0	5	6
230	R:R:F318	R:R:R321	3.21	Yes	Yes	0	8	5
231	R:R:N294	R:R:V290	2.96	No	No	0	4	3
232	R:R:L275	R:R:T278	2.95	Yes	No	0	4	4
233	R:R:I62	R:R:I83	2.94	Yes	No	0	7	6
234	R:R:I42	R:R:M43	2.92	No	No	0	6	5
235	R:R:C315	R:R:F318	2.79	No	Yes	0	8	8
236	L:L:L5	R:R:L287	2.77	No	No	0	0	2
237	R:R:L90	R:R:L94	2.77	No	No	0	8	5
238	R:R:L166	R:R:L170	2.77	No	No	0	4	4
239	R:R:A218	R:R:F213	2.77	No	No	0	5	5
240	R:R:C262	R:R:Y228	2.69	No	Yes	0	8	9
241	R:R:A227	R:R:Y142	2.67	No	Yes	0	7	8
242	R:R:A296	R:R:Y272	2.67	No	Yes	0	6	7
243	R:R:E113	R:R:L184	2.65	No	No	0	2	5
244	R:R:F81	R:R:V77	2.62	Yes	Yes	0	7	6
245	R:R:F81	R:R:V163	2.62	Yes	No	0	7	6
246	R:R:R250	R:R:T236	2.59	No	No	0	6	4
247	R:R:R321	R:R:T317	2.59	Yes	No	0	5	6
248	R:R:F47	R:R:M43	2.49	Yes	No	0	7	5
249	R:R:F154	R:R:K153	2.48	No	No	0	4	3
250	R:R:K252	R:R:R256	2.48	No	No	0	5	7
251	R:R:L314	R:R:R256	2.43	Yes	No	0	7	7
252	R:R:I231	R:R:Y142	2.42	No	Yes	0	8	8
253	R:R:I231	R:R:Y228	2.42	No	Yes	0	8	9
254	R:R:L143	R:R:Y142	2.34	No	Yes	0	4	8
255	R:R:L287	R:R:Y291	2.34	No	No	0	2	3
256	R:R:E113	R:R:R183	2.33	No	No	0	2	4
257	R:R:G189	R:R:G190	2.11	No	No	0	3	4
258	R:R:G95	R:R:P97	2.03	No	No	0	6	8
259	R:R:C51	R:R:G48	1.96	Yes	No	0	6	3
260	R:R:C305	R:R:G54	1.96	No	No	0	8	8
261	R:R:A191	R:R:P188	1.87	No	No	0	1	3
262	R:R:A240	R:R:P241	1.87	No	No	0	4	3
263	R:R:A270	R:R:P271	1.87	No	No	0	5	9
264	R:R:A296	R:R:P271	1.87	No	No	0	6	9
265	R:R:A182	R:R:C116	1.81	No	No	10	4	9
266	R:R:A182	R:R:C194	1.81	No	No	10	4	9
267	R:R:P186	R:R:V192	1.77	No	No	0	2	4
268	R:R:G57	R:R:I56	1.76	No	No	0	7	4
269	L:L:M4	R:R:G107	1.75	No	No	0	0	4
270	R:R:G105	R:R:M104	1.75	No	No	0	4	5
271	L:L:G10	L:L:L9	1.71	No	Yes	0	0	0
272	R:R:G54	R:R:L53	1.71	No	No	0	8	5
273	R:R:G54	R:R:L93	1.71	No	No	0	8	7
274	R:R:G193	R:R:L184	1.71	No	No	0	5	5
275	R:R:A240	R:R:S237	1.71	No	No	0	4	4
276	R:R:A295	R:R:S298	1.71	No	No	0	5	5
277	R:R:I80	R:R:P157	1.69	No	No	0	6	1
278	R:R:A182	R:R:T117	1.68	No	No	0	4	6
279	R:R:C51	R:R:I55	1.64	Yes	No	0	6	6
280	R:R:A160	R:R:I80	1.62	No	No	0	7	6
281	R:R:A121	R:R:I175	1.62	No	Yes	0	5	7
282	R:R:D202	R:R:P201	1.61	No	No	0	2	3
283	R:R:S59	R:R:T60	1.6	No	No	0	3	5
284	R:R:V222	R:R:V223	1.6	No	Yes	0	4	6
285	R:R:A258	R:R:L232	1.58	No	No	0	8	5
286	R:R:P241	R:R:Q244	1.58	No	No	0	3	4
287	R:R:C74	R:R:N75	1.57	Yes	No	0	8	4
288	R:R:T286	R:R:T288	1.57	No	No	0	1	3
289	R:R:I42	R:R:V46	1.54	No	No	0	6	5
290	R:R:I62	R:R:V66	1.54	Yes	No	0	7	3
291	R:R:I62	R:R:V87	1.54	Yes	No	0	7	6
292	R:R:H147	R:R:P148	1.53	No	No	0	6	8
293	R:R:K67	R:R:V66	1.52	No	No	0	5	3
294	R:R:I247	R:R:T251	1.52	No	No	0	4	7
295	R:R:I259	R:R:T255	1.52	No	No	0	5	6
296	R:R:F111	R:R:G112	1.51	Yes	No	0	6	7
297	R:R:L91	R:R:S126	1.5	No	No	0	6	8
298	R:R:K153	R:R:T152	1.5	No	No	0	3	5
299	R:R:L280	R:R:S281	1.5	No	No	0	5	4
300	R:R:L275	R:R:V274	1.49	Yes	No	0	4	6
301	R:R:N106	R:R:V108	1.48	No	No	0	4	5
302	R:R:L53	R:R:T49	1.47	No	No	0	5	5
303	R:R:L322	R:R:T60	1.47	No	No	0	6	5
304	R:R:L277	R:R:T209	1.47	No	No	0	6	5
305	R:R:L292	R:R:T288	1.47	No	No	0	5	3
306	R:R:F208	R:R:P177	1.44	Yes	No	0	5	8
307	R:R:P285	R:R:R284	1.44	No	No	0	1	2
308	R:R:E113	R:R:T114	1.41	No	No	0	2	3
309	R:R:L210	R:R:L277	1.38	No	No	0	4	6
310	R:R:L275	R:R:L292	1.38	Yes	No	0	4	5
311	R:R:I282	R:R:Q279	1.37	No	Yes	0	3	3
312	R:R:R284	R:R:S283	1.32	No	No	0	2	1
313	R:R:F266	R:R:V267	1.31	Yes	No	0	6	6
314	R:R:R319	R:R:V313	1.31	No	No	0	8	7
315	R:R:K320	R:R:R321	1.24	No	Yes	0	5	5
316	R:R:L249	R:R:R245	1.21	No	No	0	4	4
317	R:R:L170	R:R:Y132	1.17	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L9	4.235	6	1	0
2	R:R:F47	5.525	6	1	7
3	R:R:C51	2.9075	4	0	6
4	R:R:N58	5.44	4	6	9
5	R:R:I62	2.28	4	0	7
6	R:R:C74	3.6	4	7	8
7	R:R:V77	3.48	4	0	6
8	R:R:F81	3.595	4	0	7
9	R:R:S86	3.5075	4	0	9
10	R:R:D89	5.412	5	6	9
11	R:R:F92	7.11333	6	1	7
12	R:R:M96	7.924	5	1	7
13	R:R:F111	7.5225	4	9	6
14	R:R:Q127	8.2075	4	1	8
15	R:R:F128	7.315	4	5	6
16	R:R:Y132	3.438	5	5	6
17	R:R:T135	4.005	4	2	7
18	R:R:Y142	4.028	5	0	8
19	R:R:W168	5.9475	4	8	9
20	R:R:S174	5.3	4	5	5
21	R:R:I175	5.70833	6	5	7
22	R:R:Y181	5.26	4	3	5
23	R:R:I185	4.7875	4	4	2
24	R:R:R197	10.0525	4	4	3
25	R:R:D204	10.6	4	3	2
26	R:R:F208	6.4	4	3	5
27	R:R:V223	2.705	4	2	6
28	R:R:I224	4.335	4	2	8
29	R:R:Y228	4.68	7	2	9
30	R:R:F265	5.3975	4	1	9
31	R:R:F266	6.08	4	0	6
32	R:R:W269	8.174	5	1	8
33	R:R:Y272	6.5775	4	1	7
34	R:R:Y273	6.715	4	0	8
35	R:R:L275	2.9775	4	0	4
36	R:R:Q276	5.265	6	1	5
37	R:R:Q279	5.96833	6	1	3
38	R:R:Y293	5.372	5	1	3
39	R:R:Y301	6.63	5	1	7
40	R:R:L314	4.35	4	0	7
41	R:R:F318	5.81	5	0	8
42	R:R:R321	6.0925	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N294	R:R:V290	12.9795	2.96	No	No	0	4	3
2	R:R:L103	R:R:N294	14.5533	13.73	No	No	0	4	4
3	L:L:Y13	R:R:L103	16.002	3.52	No	No	0	0	4
4	L:L:M8	L:L:Y13	17.5713	4.79	No	No	0	0	0
5	L:L:M8	R:R:Y293	19.0334	4.79	No	Yes	0	0	3
6	R:R:Q279	R:R:Y293	49.4903	7.89	Yes	Yes	1	3	3
7	L:L:R14	R:R:Q279	18.5639	9.35	No	Yes	1	0	3
8	L:L:C7	L:L:R14	23.6922	8.36	No	No	0	0	0
9	L:L:C16	L:L:C7	21.3628	7.28	No	No	0	0	0
10	L:L:C16	R:R:F187	19.0244	11.17	No	No	0	0	1
11	L:L:L9	R:R:I196	87.4676	4.28	Yes	No	0	0	4
12	L:L:L9	R:R:Q276	69.9723	3.99	Yes	Yes	1	0	5
13	R:R:Q276	R:R:Q279	10.0823	3.84	Yes	Yes	1	5	3
14	R:R:Q276	R:R:Y272	66.7308	6.76	Yes	Yes	1	5	7
15	R:R:Y272	R:R:Y273	78.2751	10.92	Yes	Yes	0	7	8
16	R:R:Q127	R:R:Y273	80.1529	3.38	Yes	Yes	0	8	8
17	L:L:R11	R:R:Q127	14.0392	9.35	No	Yes	1	0	8
18	R:R:Y272	R:R:Y293	14.5668	5.96	Yes	Yes	1	7	3
19	R:R:I297	R:R:Y293	84.7849	4.84	No	Yes	1	5	3
20	R:R:I297	R:R:Y301	68.1525	3.63	No	Yes	1	5	7
21	R:R:F92	R:R:Y301	68.2151	6.19	Yes	Yes	1	7	7
22	R:R:D123	R:R:F92	27.828	8.36	No	Yes	1	6	7
23	L:L:V12	R:R:I196	85.2499	6.14	No	No	0	0	4
24	L:L:V12	R:R:Q102	47.6616	8.6	No	No	0	0	5
25	L:L:V12	R:R:G195	37.4899	3.68	No	No	0	0	3
26	R:R:G195	R:R:I185	34.8699	3.53	No	Yes	0	3	2
27	R:R:I185	R:R:R197	10.8692	3.76	Yes	Yes	4	2	3
28	R:R:F47	R:R:I297	17.0929	3.77	Yes	No	1	7	5
29	R:R:F47	R:R:M96	11.7097	3.73	Yes	Yes	1	7	7
30	R:R:M96	R:R:Y301	14.7054	15.57	Yes	Yes	1	7	7
31	R:R:C51	R:R:M96	21.5148	4.86	Yes	Yes	0	6	7
32	R:R:C51	R:R:L93	18.926	3.17	Yes	No	0	6	7
33	R:R:G54	R:R:L93	34.0472	1.71	No	No	0	8	7
34	R:R:F92	R:R:S304	100	7.93	Yes	No	0	7	9
35	R:R:L93	R:R:S304	24.2735	3	No	No	0	7	9
36	R:R:G54	R:R:L53	22.7622	1.71	No	No	0	8	5
37	R:R:F309	R:R:L53	17.0661	3.65	No	No	0	6	5
38	R:R:F309	R:R:G57	14.2046	3.01	No	No	0	6	7
39	R:R:G57	R:R:I56	11.3342	1.76	No	No	0	7	4
40	R:R:D89	R:R:S304	86.8461	5.89	Yes	No	0	9	9
41	R:R:D89	R:R:N58	72.8517	5.39	Yes	Yes	6	9	9
42	R:R:N58	R:R:S86	69.1407	2.98	Yes	Yes	0	9	9
43	R:R:S86	R:R:V61	29.0307	4.85	Yes	No	0	9	9
44	R:R:I312	R:R:V61	27.4792	3.07	No	No	0	7	9
45	R:R:I62	R:R:S86	12.2642	3.1	Yes	Yes	0	7	9
46	R:R:F318	R:R:I312	25.9277	7.54	Yes	No	0	8	7
47	R:R:I82	R:R:S86	28.7222	3.1	No	Yes	0	8	9
48	R:R:I82	R:R:Y311	27.1484	13.3	No	No	0	8	9
49	R:R:F318	R:R:Y311	25.6818	11.35	Yes	No	0	8	9
50	R:R:F318	R:R:R321	42.1756	3.21	Yes	Yes	0	8	5
51	R:R:K68	R:R:R321	19.6191	17.33	No	Yes	0	5	5
52	R:R:D79	R:R:K68	16.4446	5.53	No	No	0	8	5
53	R:R:Q127	R:R:W269	94.7912	14.24	Yes	Yes	1	8	8
54	R:R:F265	R:R:W269	84.7894	4.01	Yes	Yes	1	9	8
55	R:R:F265	R:R:L134	86.4079	3.65	Yes	No	0	9	8
56	R:R:I224	R:R:L134	85.3841	4.28	Yes	No	0	8	8
57	R:R:I224	R:R:Y228	74.4076	3.63	Yes	Yes	2	8	9
58	R:R:R141	R:R:Y228	22.9098	5.14	No	Yes	0	9	9
59	R:R:M137	R:R:R141	21.5416	13.65	No	No	0	9	9
60	R:R:F81	R:R:M137	20.0528	4.98	Yes	No	0	7	9
61	R:R:F81	R:R:V77	15.6398	2.62	Yes	Yes	0	7	6
62	R:R:D89	R:R:S130	15.4699	4.42	Yes	No	0	9	9
63	R:R:S130	R:R:V88	13.9542	3.23	No	No	0	9	8
64	R:R:Q102	R:R:W109	29.603	10.95	No	No	0	5	8
65	R:R:F111	R:R:W109	16.1719	12.03	Yes	No	9	6	8
66	R:R:F111	R:R:F98	10.8871	7.5	Yes	No	0	6	6
67	R:R:D123	R:R:M99	38.8357	9.7	No	No	0	6	6
68	R:R:M99	R:R:T120	36.8059	3.01	No	No	0	6	5
69	R:R:H101	R:R:W109	10.7798	11.64	No	No	9	4	8
70	R:R:C194	R:R:Q102	16.2747	4.58	No	No	0	9	5
71	R:R:A182	R:R:C194	10.8692	1.81	No	No	10	4	9
72	R:R:T120	R:R:V178	34.7805	4.76	No	No	0	5	5
73	R:R:I175	R:R:V178	32.6165	4.61	Yes	No	0	7	5
74	R:R:F128	R:R:I175	14.4594	11.3	Yes	Yes	5	6	7
75	R:R:I175	R:R:S174	10.8245	6.19	Yes	Yes	5	7	5
76	R:R:S174	R:R:Y132	10.2298	3.82	Yes	Yes	5	5	6
77	R:R:I224	R:R:T135	12.5861	4.56	Yes	Yes	2	8	7
78	R:R:I231	R:R:Y228	24.6043	2.42	No	Yes	0	8	9
79	R:R:I231	R:R:Y142	21.6534	2.42	No	Yes	0	8	8
80	R:R:Q212	R:R:Q276	25.7623	5.12	No	Yes	0	5	5
81	R:R:F208	R:R:Q212	23.8085	14.05	Yes	No	0	5	5
82	R:R:I185	R:R:P186	18.9618	3.39	Yes	No	0	2	2
83	R:R:P186	R:R:V192	16.2792	1.77	No	No	0	2	4
84	R:R:L184	R:R:V192	13.5876	10.43	No	No	0	5	4
85	R:R:Q276	R:R:T209	11.6829	8.5	Yes	No	0	5	5
86	R:R:A258	R:R:Y228	21.5506	4	No	Yes	0	8	9
87	R:R:I261	R:R:Y228	12.4922	10.88	No	Yes	0	8	9
88	R:R:A258	R:R:L232	20.0528	1.58	No	No	0	8	5
89	R:R:L232	R:R:V254	15.528	4.47	No	No	0	5	7
90	R:R:M235	R:R:V254	14.1107	7.61	No	No	0	8	7
91	R:R:M235	R:R:T251	12.5771	4.52	No	No	0	8	7
92	R:R:I247	R:R:T251	11.0391	1.52	No	No	0	4	7
93	R:R:R321	R:R:T317	16.3418	2.59	Yes	No	0	5	6
94	R:R:E316	R:R:T317	13.0466	8.47	No	No	0	5	6
95	R:R:I261	R:R:T257	10.9631	3.04	No	No	0	8	8
96	R:R:F289	R:R:Q279	13.2344	9.37	No	Yes	0	4	3
97	R:R:F289	R:R:L275	11.3699	6.09	No	Yes	0	4	4
98	R:R:Q276	R:R:Y293	40.8835	3.38	Yes	Yes	1	5	3
99	L:L:L9	R:R:Q279	28.1901	3.99	Yes	Yes	1	0	3
100	R:R:F92	R:R:Q127	72.5923	5.86	Yes	Yes	1	7	8
101	L:L:R11	R:R:D123	13.2388	9.53	No	No	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:M4	R:R:P188	3.35	0	No	No	0	3	0	1
L:L:L5	R:R:V290	4.47	0	No	No	0	3	0	1
L:L:R6	R:R:F187	6.41	0	No	No	0	1	0	1
L:L:M8	R:R:Y293	4.79	0	No	Yes	0	3	0	1
L:L:L9	R:R:I196	4.28	1	Yes	No	0	4	0	1
L:L:L9	R:R:L205	4.15	1	Yes	No	0	5	0	1
L:L:L9	R:R:Q276	3.99	1	Yes	Yes	0	5	0	1
L:L:L9	R:R:Q279	3.99	1	Yes	Yes	0	3	0	1
L:L:R11	R:R:F92	6.41	1	No	Yes	0	7	0	1
L:L:R11	R:R:D123	9.53	1	No	No	0	6	0	1
L:L:R11	R:R:Q127	9.35	1	No	Yes	0	8	0	1
L:L:V12	R:R:Q102	8.6	0	No	No	0	5	0	1
L:L:V12	R:R:G195	3.68	0	No	No	0	3	0	1
L:L:V12	R:R:I196	6.14	0	No	No	0	4	0	1
L:L:Y13	R:R:L103	3.52	0	No	No	0	4	0	1
L:L:R14	R:R:Q279	9.35	1	No	Yes	0	3	0	1
L:L:P15	R:R:I185	8.47	4	No	Yes	0	2	0	1
L:L:P15	R:R:R197	12.97	4	No	Yes	0	3	0	1
L:L:C16	R:R:F187	11.17	0	No	No	0	1	0	1
L:L:W17	R:R:R284	13	0	No	No	0	2	0	1
L:L:Q18	R:R:R197	10.51	4	No	Yes	0	3	0	1
L:L:Q18	R:R:P201	3.16	4	No	No	0	3	0	1
R:R:D123	R:R:F92	8.36	1	No	Yes	6	7	1	1
R:R:F92	R:R:S126	7.93	1	Yes	No	7	8	1	2
R:R:F92	R:R:Q127	5.86	1	Yes	Yes	7	8	1	1
R:R:F92	R:R:Y301	6.19	1	Yes	Yes	7	7	1	2
R:R:F92	R:R:S304	7.93	1	Yes	No	7	9	1	2
R:R:D123	R:R:M99	9.7	1	No	No	6	6	1	2
R:R:Q102	R:R:W109	10.95	0	No	No	5	8	1	2
R:R:C194	R:R:Q102	4.58	10	No	No	9	5	2	1
R:R:L103	R:R:N294	13.73	0	No	No	4	4	1	2
R:R:Q127	R:R:W269	14.24	1	Yes	Yes	8	8	1	2
R:R:Q127	R:R:Y273	3.38	1	Yes	Yes	8	8	1	2
R:R:I185	R:R:P186	3.39	4	Yes	No	2	2	1	2
R:R:G195	R:R:I185	3.53	0	No	Yes	3	2	1	1
R:R:I185	R:R:R197	3.76	4	Yes	Yes	2	3	1	1
R:R:F187	R:R:P188	4.33	0	No	No	1	3	1	1
R:R:P201	R:R:R197	12.97	4	No	Yes	3	3	1	1
R:R:L205	R:R:L280	6.92	0	No	No	5	5	1	2
R:R:Q276	R:R:T209	8.5	1	Yes	No	5	5	1	2
R:R:L280	R:R:T209	4.42	0	No	No	5	5	2	2
R:R:Q212	R:R:Q276	5.12	0	No	Yes	5	5	2	1
R:R:Y272	R:R:Y273	10.92	1	Yes	Yes	7	8	2	2
R:R:Q276	R:R:Y272	6.76	1	Yes	Yes	5	7	1	2
R:R:Y272	R:R:Y293	5.96	1	Yes	Yes	7	3	2	1
R:R:Q276	R:R:Q279	3.84	1	Yes	Yes	5	3	1	1
R:R:Q276	R:R:Y293	3.38	1	Yes	Yes	5	3	1	1
R:R:F289	R:R:Q279	9.37	0	No	Yes	4	3	2	1
R:R:Q279	R:R:Y293	7.89	1	Yes	Yes	3	3	1	1
R:R:P285	R:R:V290	3.53	0	No	No	1	3	2	1
R:R:I297	R:R:Y293	4.84	1	No	Yes	5	3	2	1
R:R:I297	R:R:Y301	3.63	1	No	Yes	5	7	2	2
R:R:N294	R:R:V290	2.96	0	No	No	4	3	2	1
L:L:L5	R:R:L287	2.77	0	No	No	0	2	0	1
R:R:L287	R:R:Y291	2.34	0	No	No	2	3	1	2
R:R:A191	R:R:P188	1.87	0	No	No	1	3	2	1
L:L:M4	R:R:G107	1.75	0	No	No	0	4	0	1
R:R:D202	R:R:P201	1.61	0	No	No	2	3	2	1
R:R:P285	R:R:R284	1.44	0	No	No	1	2	2	1
R:R:I282	R:R:Q279	1.37	0	No	Yes	3	3	2	1
R:R:R284	R:R:S283	1.32	0	No	No	2	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WSS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	281
Number of Links	317
Number of Hubs	42
Number of Links mediated by Hubs	159
Number of Communities	10
Number of Nodes involved in Communities	55
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	65344
Length Of Smallest Path	3
Average Path Length	14.4452
Length of Longest Path	29
Minimum Path Strength	1.38
Average Path Strength	5.66796
Maximum Path Strength	14.875
Minimum Path Correlation	0.7
Average Path Correlation	0.933718
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.975
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.7502
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • melanin-concentrating hormone receptor binding • signaling receptor binding • type 1 melanin-concentrating hormone receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • melanin-concentrating hormone activity • receptor ligand activity • signaling receptor activator activity • neuropeptide signaling pathway • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission, dopaminergic • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • trans-synaptic signaling • regulation of signaling • regulation of synaptic transmission, dopaminergic • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • synaptic transmission, dopaminergic • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • behavior • feeding behavior • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • melanin-concentrating hormone receptor activity • protein-hormone receptor activity • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • metabolic process • generation of precursor metabolites and energy • ciliary membrane • plasma membrane region • cell projection membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99705
Sequence	>8WSS_nogp_Chain_R Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S C N N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G N G V W H F G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H P I S S T K F R K P S V A T L V I C L L W A L S F I S I T P V W L Y A R L I P F P G G A V G C G I R L P N P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M T S S V A P A S Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I S R P T L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T F R K R L V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published

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