Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 3.5625459
2A:A:L23 3.54456
3A:A:V34 6.176545
4A:A:L37 6.748519
5A:A:L38 3.8475448
6A:A:L39 4.10833609
7A:A:G40 2.6275409
8A:A:K46 4.624549
9A:A:I49 3.646547
10A:A:M53 3.0975448
11A:A:I184 3.9325419
12A:A:E186 8.195419
13A:A:F191 6.03545
14A:A:L194 5.1775444
15A:A:F196 7.6647
16A:A:K197 7.428516
17A:A:F199 9.306515
18A:A:V201 4.335419
19A:A:Q204 5.226519
20A:A:S206 4.476518
21A:A:E207 6.82519
22A:A:K210 5.25875819
23A:A:W211 6.14167619
24A:A:H213 6.3375418
25A:A:C214 4.26417
26A:A:F215 6.32778919
27A:A:I222 3.416547
28A:A:F223 5.774539
29A:A:V225 4.558537
30A:A:L227 5.93437
31A:A:S228 6.035439
32A:A:D229 5.636538
33A:A:Y230 6.0575838
34A:A:M243 3.105638
35A:A:F250 5.69571739
36A:A:C254 4.308535
37A:A:W258 7.62429715
38A:A:F259 5.52719
39A:A:I265 3.468548
40A:A:L266 4.635639
41A:A:F267 4.32111949
42A:A:L268 6.236538
43A:A:N269 4.5925449
44A:A:F274 3.83286739
45A:A:I278 4.6225436
46A:A:S281 5.4125437
47A:A:L283 4.76333637
48A:A:C286 4.824536
49A:A:Y287 6.16125837
50A:A:Y296 5.77333634
51A:A:Y302 10.115436
52A:A:I303 3.355637
53A:A:F307 4.21429738
54A:A:N311 5.392538
55A:A:R313 4.765434
56A:A:K317 4.56437
57A:A:E318 6.68556944
58A:A:Y320 6.47857747
59A:A:T321 7.52435
60A:A:H322 10.4325449
61A:A:F323 4.54634
62A:A:T324 7.3575449
63A:A:C325 2.7975407
64A:A:N331 8.155448
65A:A:F334 7.525643
66A:A:F336 5.185648
67A:A:V339 4.425448
68A:A:D341 8.01448
69A:A:V342 3.3225447
70A:A:K345 4.955445
71A:A:L348 3.4625409
72A:A:K349 4.2525445
73A:A:L353 5.644597
74A:A:F354 5.825445
75B:B:E3 3.1025125
76B:B:L7 3.5065128
77B:B:I18 3.738517
78B:B:R22 7.9725416
79B:B:T34 3.7225465
80B:B:I37 4.464562
81B:B:V40 3.63167663
82B:B:I43 4.202563
83B:B:M45 4.44564
84B:B:R48 6.015457
85B:B:R49 4.9475457
86B:B:L51 9.83459
87B:B:H54 8.61167659
88B:B:I58 4.5825459
89B:B:Y59 8.616518
90B:B:M61 3.678556
91B:B:W63 5.38286757
92B:B:L70 4.274555
93B:B:V71 4.35488
94B:B:D76 5.03559
95B:B:L79 4.54333687
96B:B:I80 9.6625458
97B:B:I81 4.2625487
98B:B:W82 10.5629759
99B:B:D83 7.35458
100B:B:S84 3.94455
101B:B:Y85 11.5554
102B:B:N88 5.854557
103B:B:K89 7.64759
104B:B:H91 6.245485
105B:B:I93 7.27487
106B:B:L95 4.064588
107B:B:W99 7.56111919
108B:B:Y105 4.64714786
109B:B:N110 6.565414
110B:B:Y111 5.42667614
111B:B:V112 4.816588
112B:B:C114 4.056588
113B:B:L117 3.66167619
114B:B:C121 3.7375418
115B:B:I123 4.282516
116B:B:Y124 4.54886
117B:B:L126 4.79585
118B:B:T128 5.19754143
119B:B:E130 4.334143
120B:B:V133 7.2125484
121B:B:E138 5.14486
122B:B:H142 6.27143719
123B:B:Y145 5.7141018
124B:B:L146 3.86517
125B:B:C149 4.2625418
126B:B:R150 6.21476
127B:B:F151 4.74819
128B:B:Q156 6.4125405
129B:B:I157 4.418517
130B:B:T159 5.375619
131B:B:S161 7.1075419
132B:B:G162 6.0675419
133B:B:D163 8.0825419
134B:B:C166 4.235478
135B:B:L168 3.384576
136B:B:W169 9.86833618
137B:B:I171 4.2416
138B:B:Q176 7.265414
139B:B:F180 7.85333677
140B:B:H183 7.95857779
141B:B:D186 6.48167619
142B:B:V187 4.702579
143B:B:L190 4.022575
144B:B:F199 5.68714779
145B:B:V200 7.1875416
146B:B:S201 4.915479
147B:B:C204 6.886517
148B:B:D205 5.936579
149B:B:K209 11.8225476
150B:B:L210 6.24405
151B:B:W211 8.40667678
152B:B:Q220 8.7075417
153B:B:F222 6.56667618
154B:B:H225 8.23125819
155B:B:D228 7.092519
156B:B:I229 6.27417
157B:B:I232 5.095418
158B:B:F234 5.338505
159B:B:F235 6.05571716
160B:B:P236 6.3625417
161B:B:N237 7.6225415
162B:B:F241 7.03857716
163B:B:T243 5.844518
164B:B:S245 7.3425419
165B:B:D246 6.4725419
166B:B:D247 8.094519
167B:B:T249 5.742516
168B:B:R251 11.772518
169B:B:F253 7.86616
170B:B:L255 4.555416
171B:B:D258 9.494517
172B:B:Q259 4.676506
173B:B:M262 6.655414
174B:B:Y264 5.86833615
175B:B:H266 7.21414
176B:B:I269 3.86833614
177B:B:C271 4.2725415
178B:B:F278 4.90143717
179B:B:G282 2.76519
180B:B:R283 7.56669
181B:B:L284 4.962565
182B:B:L285 4.79416
183B:B:Y289 6.82143717
184B:B:D290 10.15416
185B:B:N295 7.618516
186B:B:V296 3.8475465
187B:B:W297 4.16667618
188B:B:L300 6.2575466
189B:B:K301 4.02857765
190B:B:R304 7.462515
191B:B:H311 8.814569
192B:B:R314 14.72418
193B:B:M325 5.7875455
194B:B:V327 3.23566
195B:B:W332 10.01719
196B:B:D333 7.8875469
197B:B:F335 7.165404
198B:B:L336 4.72167657
199B:B:K337 7.304566
200B:B:W339 7.26286769
201B:B:N340 8.6325459
202G:G:R27 6.068518
203G:G:I28 4.7575404
204G:G:Y40 7.5025416
205G:G:D48 6.976509
206G:G:P49 4.7825407
207G:G:L51 4.515666
208G:G:N59 5.855459
209G:G:F61 5.115858
210R:R:M43 6.432525
211R:R:F47 6.056527
212R:R:V77 3.945106
213R:R:P78 5.334108
214R:R:I80 3.1075406
215R:R:F81 5.34107
216R:R:I83 3.33254156
217R:R:D89 5.89509
218R:R:F92 6.73333627
219R:R:M96 6.71527
220R:R:P97 2.5375428
221R:R:M99 4.0875426
222R:R:M104 6.885425
223R:R:W109 7.228577118
224R:R:F111 7.4454116
225R:R:M115 3.11406
226R:R:N125 6.244525
227R:R:F128 5.10833626
228R:R:T129 7.362527
229R:R:R141 6.36167699
230R:R:Y142 6.52754168
231R:R:R155 5.1665106
232R:R:W168 4.54529
233R:R:I175 2.94527
234R:R:T176 3.2825424
235R:R:I185 5.17754172
236R:R:C194 5.99754119
237R:R:L198 3.26525
238R:R:P199 4.2375424
239R:R:N200 5.725424
240R:R:D204 6.31522
241R:R:W207 3.546525
242R:R:F208 4.21425
243R:R:Y211 4.09167623
244R:R:F213 5.6325425
245R:R:L215 4.4875424
246R:R:F217 5.478528
247R:R:P220 4.165429
248R:R:Y228 5.275899
249R:R:M235 5.4575448
250R:R:P241 4.446543
251R:R:I247 4.612544
252R:R:R250 5.3775846
253R:R:R253 9.5025447
254R:R:F265 3.94167629
255R:R:W269 5.95625828
256R:R:Y272 4.165627
257R:R:Y273 4.81286728
258R:R:Q276 5.7625425
259R:R:F289 3.8825404
260R:R:Y293 4.882523
261R:R:I297 3.9775425
262R:R:Y301 8.906527
263R:R:N303 7.2775429
264R:R:L314 3.76507
265R:R:F318 6.67508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S316 B:B:W332 11.6636.18NoYes099
2A:A:W258 B:B:W332 11.0363.75YesYes159
3A:A:I212 A:A:W258 23.24772.35NoYes085
4A:A:I212 A:A:R208 23.27123.76NoNo089
5A:A:L39 A:A:R208 61.84792.43YesNo099
6A:A:G40 A:A:L39 80.31211.71YesYes099
7A:A:G40 A:A:K46 1005.23YesYes099
8A:A:K46 A:A:L38 66.17875.64YesYes498
9A:A:I222 A:A:L38 58.36582.85YesYes478
10A:A:R208 A:A:W211 39.49228NoYes099
11A:A:F223 A:A:L39 17.29733.65YesYes099
12A:A:C224 A:A:K46 33.88293.23NoYes479
13A:A:C224 A:A:I49 16.98573.27NoYes477
14A:A:F267 A:A:I222 16.74942.51YesYes497
15A:A:F267 A:A:I49 16.78075.02YesYes497
16A:A:C224 A:A:N269 16.90713.15NoYes479
17A:A:F267 A:A:N269 16.7093.62YesYes499
18A:A:K210 B:B:Y145 23.04974.78YesYes198
19A:A:K210 B:B:D246 22.60344.15YesYes199
20A:A:I222 A:A:I265 33.3452.94YesYes478
21A:A:F334 A:A:I265 16.71832.51YesYes438
22A:A:F334 A:A:Y320 66.73862.06YesYes437
23A:A:F267 A:A:F334 50.15044.29YesYes493
24A:A:A338 A:A:I265 16.64024.87NoYes468
25A:A:A338 A:A:Y320 16.63476.67NoYes467
26A:A:F223 A:A:L249 14.38716.09YesNo099
27A:A:G40 A:A:L249 14.51771.71YesNo099
28A:A:F223 A:A:F250 12.140212.86YesYes399
29A:A:F307 A:A:M243 13.11822.49YesYes388
30A:A:E318 A:A:Y320 42.204713.47YesYes447
31A:A:E318 R:R:R250 40.30623.49YesYes446
32A:A:D341 R:R:R250 40.264710.72YesYes486
33A:A:D341 A:A:Y320 40.445911.49YesYes487
34A:A:L348 R:R:R250 76.64282.43YesYes096
35A:A:L348 A:A:L353 83.75094.15YesYes097
36A:A:L353 R:R:R141 33.41519.72YesYes979
37A:A:L353 R:R:Y228 49.94577.03YesYes979
38B:B:D246 B:B:S227 22.57452.94YesNo196
39B:B:S227 B:B:S245 12.86254.89NoYes169
40B:B:F253 B:B:H225 10.14814.53YesYes169
41R:R:I224 R:R:Y228 46.15122.42NoYes089
42R:R:I224 R:R:L134 42.22984.28NoNo088
43R:R:F265 R:R:L134 42.01733.65YesNo098
44R:R:F265 R:R:W269 40.78092YesYes298
45R:R:W269 R:R:Y272 11.49121.93YesYes287
46R:R:M137 R:R:R141 30.22038.69NoYes099
47R:R:L85 R:R:M137 35.42632.83NoNo099
48R:R:D89 R:R:L85 34.39885.43YesNo099
49R:R:D89 R:R:S304 31.190610.31YesNo099
50R:R:F92 R:R:S304 29.68136.61YesNo079
51R:R:D123 R:R:F92 25.0152.39NoYes267
52R:R:D123 R:R:M99 24.54368.32NoYes266
53R:R:M99 R:R:Q102 22.68242.72YesNo065
54R:R:F92 R:R:W269 25.1353.01YesYes278
55R:R:F92 R:R:Y301 29.308519.6YesYes277
56R:R:M99 R:R:Y301 24.59892.39YesYes267
57R:R:Q102 R:R:W109 20.79585.48NoYes058
58R:R:I119 R:R:M99 25.51652.92NoYes056
59R:R:I119 R:R:W109 20.79145.87NoYes058
60R:R:C194 R:R:W109 18.905313.06YesYes1198
61R:R:C194 R:R:G195 15.12491.96YesNo093
62R:R:G195 R:R:I185 13.23433.53NoYes032
63A:A:W211 B:B:Y145 38.85651.93YesYes198
64A:A:W258 B:B:R314 11.97264YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WWJ
Class A
SubFamily Peptide
Type Melanin Concentrating Hormone
SubType MCH1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.03
Date 2024-11-13
D.O.I. To be published
Net Summary
Imin 1.84
Number of Linked Nodes 861
Number of Links 1261
Number of Hubs 265
Number of Links mediated by Hubs 937
Number of Communities 17
Number of Nodes involved in Communities 385
Number of Links involved in Communities 677
Path Summary
Number Of Nodes in MetaPath 65
Number Of Links MetaPath 64
Number of Shortest Paths 8499718
Length Of Smallest Path 3
Average Path Length 28.4175
Length of Longest Path 49
Minimum Path Strength 1.385
Average Path Strength 5.02338
Maximum Path Strength 25.5
Minimum Path Correlation 0.7
Average Path Correlation 0.996232
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 37.5143
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 68.1526
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • signaling receptor binding   • neuropeptide binding   • peptide binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • neuropeptide receptor activity   • melanin-concentrating hormone receptor activity   • protein-hormone receptor activity   • hormone binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell surface receptor signaling pathway
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell surface receptor signaling pathway   • regulation of localization   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • transport   • regulation of transport   • regulation of monoatomic ion transport   • positive regulation of biological process   • establishment of localization   • calcium ion transport   • metal ion transport   • localization   • positive regulation of transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • monoatomic cation transport   • regulation of metal ion transport   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • metabolic process   • generation of precursor metabolites and energy   • behavior   • multicellular organismal process   • feeding behavior   • membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • non-motile cilium   • ciliary membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane
Gene OntologyCellular Component• membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • non-motile cilium   • ciliary membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • neuron projection   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8WWJ_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLAEDEEM NRMHSMKLF DSICNNKWF TDTSIILFL 
NKKDLFEEK IKKSPLTIC YPEYAGSNT YEEAAAYIQ CQFEDLNKR 
KDTKEIYTH FTCTDTKNV QFVFDAVTD VIIKNNLKD CGLFNAAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8WWJ_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8WWJ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99705
Sequence
>8WWJ_Chain_R
YINIIMPSV FGTICLLGI IGNSTVIFA VVKKSKLHW CNNVPDIFI 
INLSVVDLL FLLGMPFMI HQLMGNGVW HFGETMCTL ITAMDANSQ 
FTSTYILTA MAIDRYLAT VHPISSTKF RKPSVATLV ICLLWALSF 
ISITPVWLY ARLIPFPGG AVGCGIRLP NPDTDLYWF TLYQFFLAF 
ALPFVVITA AYVRILQRM TSSVAPASQ RSIRLRTKR VTRTAIAIC 
LVFFVCWAP YYVLQLTQL SISRPTLTF VYLYNAAIS LGYANSCLN 
PFVYIVLCE TFRKRLVLS V


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WWNAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.652024-11-13To be published
8WWMAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.812024-11-13To be published
8WWLAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.782024-11-13To be published
8WWKAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.612024-11-13To be published
8WWJAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.032024-11-13To be published
8WWIAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.432024-11-13To be published
8WWHAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ22.842024-11-13To be published
8WSSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensPro-MCH-Gi1/β1/γ13.012024-06-1910.1038/s41421-024-00679-8
8YNTAPeptideMelanin Concentrating HormoneMCH1Homo sapiensSNAP-94847--3.432024-12-1810.1038/s41421-024-00754-0
8YNSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensSNAP-94847--3.332024-12-1810.1038/s41421-024-00754-0




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