psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F2	L:L:M4	4.98	Yes	No	0	0	0
2	L:L:F2	L:L:R6	11.76	Yes	Yes	2	0	0
3	L:L:F2	R:R:N106	4.83	Yes	No	0	0	4
4	L:L:F2	R:R:G107	9.03	Yes	No	2	0	4
5	L:L:D3	L:L:L5	10.86	No	No	0	0	0
6	L:L:M4	R:R:Y291	4.79	No	No	0	0	3
7	L:L:R6	L:L:Y13	12.35	Yes	Yes	2	0	0
8	L:L:R6	R:R:G107	4.5	Yes	No	2	0	4
9	L:L:R6	R:R:F187	16.03	Yes	Yes	2	0	1
10	L:L:C7	L:L:R14	12.54	No	No	0	0	0
11	L:L:C16	L:L:C7	7.28	No	No	0	0	0
12	L:L:C7	R:R:P285	3.77	No	No	0	0	1
13	L:L:M8	L:L:Y13	5.99	No	Yes	0	0	0
14	L:L:M8	R:R:Y293	11.97	No	Yes	0	0	3
15	L:L:L9	L:L:R14	6.07	Yes	No	3	0	0
16	L:L:L9	R:R:I196	4.28	Yes	No	3	0	4
17	L:L:L9	R:R:L205	4.15	Yes	No	3	0	5
18	L:L:L9	R:R:F208	7.31	Yes	Yes	3	0	5
19	L:L:G10	R:R:Q276	4.93	No	Yes	0	0	5
20	L:L:R11	R:R:F92	8.55	Yes	Yes	1	0	7
21	L:L:R11	R:R:D123	8.34	Yes	Yes	1	0	6
22	L:L:R11	R:R:Q127	12.85	Yes	Yes	1	0	8
23	L:L:R11	R:R:Y272	7.2	Yes	Yes	1	0	7
24	L:L:R11	R:R:I297	5.01	Yes	No	0	0	5
25	L:L:R11	R:R:Y301	6.17	Yes	Yes	1	0	7
26	L:L:V12	R:R:T120	4.76	No	Yes	0	0	5
27	L:L:V12	R:R:G195	3.68	No	No	0	0	3
28	L:L:Y13	R:R:Q102	10.15	Yes	No	2	0	5
29	L:L:Y13	R:R:L103	7.03	Yes	No	0	0	4
30	L:L:Y13	R:R:F187	13.41	Yes	Yes	2	0	1
31	L:L:R14	R:R:L205	4.86	No	No	3	0	5
32	L:L:P15	R:R:I185	6.77	No	Yes	0	0	2
33	L:L:W17	R:R:P201	9.46	No	No	0	0	3
34	L:L:W17	R:R:D202	16.75	No	No	0	0	2
35	R:R:I39	R:R:Y291	9.67	No	No	0	3	3
36	R:R:I41	R:R:N40	8.5	No	No	0	4	4
37	R:R:M43	R:R:P44	3.35	Yes	No	1	5	5
38	R:R:F47	R:R:M43	7.46	Yes	Yes	1	7	5
39	R:R:M104	R:R:M43	4.33	No	Yes	1	5	5
40	R:R:M43	R:R:N294	8.41	Yes	No	0	5	4
41	R:R:M104	R:R:P44	6.71	No	No	1	5	5
42	R:R:F47	R:R:M96	4.98	Yes	Yes	1	7	7
43	R:R:F47	R:R:I100	8.79	Yes	No	1	7	6
44	R:R:F47	R:R:S298	3.96	Yes	No	0	7	5
45	R:R:C51	R:R:M96	4.86	No	Yes	0	6	7
46	R:R:C305	R:R:L53	4.76	No	No	0	8	5
47	R:R:F309	R:R:L53	4.87	No	No	0	6	5
48	R:R:C305	R:R:G54	3.92	No	No	0	8	8
49	R:R:I55	R:R:L90	4.28	No	No	0	6	8
50	R:R:G57	R:R:P308	4.06	No	No	0	7	9
51	R:R:F309	R:R:G57	4.52	No	No	0	6	7
52	R:R:D89	R:R:N58	6.73	Yes	No	0	9	9
53	R:R:N58	R:R:P308	13.03	No	No	0	9	9
54	R:R:L322	R:R:T60	4.42	No	No	0	6	5
55	R:R:S86	R:R:V61	8.08	No	No	0	9	9
56	R:R:D79	R:R:V65	4.38	No	No	0	8	7
57	R:R:I83	R:R:V65	10.75	No	No	0	6	7
58	R:R:D79	R:R:K68	12.44	No	No	0	8	5
59	R:R:K68	R:R:R321	11.14	No	No	0	5	5
60	R:R:C74	R:R:S69	3.44	No	No	0	8	6
61	R:R:N76	R:R:P78	14.66	No	No	0	8	8
62	R:R:D79	R:R:N76	13.46	No	No	0	8	8
63	R:R:P78	R:R:V77	3.53	No	Yes	0	8	6
64	R:R:D140	R:R:V77	4.38	No	Yes	0	8	6
65	R:R:A160	R:R:V77	5.09	No	Yes	0	7	6
66	R:R:A160	R:R:I80	4.87	No	No	0	7	6
67	R:R:A136	R:R:F81	4.16	No	Yes	0	7	7
68	R:R:F81	R:R:M137	6.22	Yes	No	0	7	9
69	R:R:D140	R:R:F81	9.55	No	Yes	0	8	7
70	R:R:F81	R:R:I164	6.28	Yes	No	0	7	7
71	R:R:I82	R:R:M137	4.37	No	No	0	8	9
72	R:R:I82	R:R:Y311	12.09	No	No	0	8	9
73	R:R:I164	R:R:N84	12.74	No	No	0	7	9
74	R:R:D89	R:R:L85	8.14	Yes	No	0	9	9
75	R:R:I133	R:R:L85	5.71	No	No	0	8	9
76	R:R:T129	R:R:V88	7.93	Yes	No	4	7	8
77	R:R:V88	R:R:W168	4.9	No	No	4	8	9
78	R:R:D89	R:R:S130	4.42	Yes	No	0	9	9
79	R:R:D89	R:R:S304	11.78	Yes	No	0	9	9
80	R:R:D89	R:R:N307	6.73	Yes	No	0	9	9
81	R:R:D123	R:R:F92	8.36	Yes	Yes	1	6	7
82	R:R:F92	R:R:S126	5.28	Yes	No	0	7	8
83	R:R:F92	R:R:Q127	4.68	Yes	Yes	1	7	8
84	R:R:F92	R:R:Y301	14.44	Yes	Yes	1	7	7
85	R:R:F92	R:R:S304	6.61	Yes	No	0	7	9
86	R:R:L93	R:R:S304	4.5	No	No	0	7	9
87	R:R:M96	R:R:P97	3.35	Yes	No	0	7	8
88	R:R:I100	R:R:M96	5.83	No	Yes	1	6	7
89	R:R:M96	R:R:Y301	20.35	Yes	Yes	1	7	7
90	R:R:F111	R:R:F98	6.43	No	No	0	6	6
91	R:R:F98	R:R:I119	3.77	No	No	0	6	5
92	R:R:M99	R:R:T120	4.52	No	Yes	0	6	5
93	R:R:D123	R:R:M99	15.25	Yes	No	0	6	6
94	R:R:I100	R:R:M104	4.37	No	No	1	6	5
95	R:R:H101	R:R:W109	11.64	No	Yes	2	4	8
96	R:R:F111	R:R:H101	14.71	No	No	2	6	4
97	R:R:Q102	R:R:W109	9.86	No	Yes	2	5	8
98	R:R:C194	R:R:Q102	4.58	Yes	No	2	9	5
99	R:R:N106	R:R:V108	4.43	No	No	0	4	5
100	R:R:H110	R:R:V108	8.3	No	No	0	2	5
101	R:R:F111	R:R:W109	10.02	No	Yes	2	6	8
102	R:R:C116	R:R:W109	5.22	No	Yes	2	9	8
103	R:R:I119	R:R:W109	5.87	No	Yes	0	5	8
104	R:R:L184	R:R:W109	3.42	No	Yes	0	5	8
105	R:R:C194	R:R:W109	15.67	Yes	Yes	2	9	8
106	R:R:E113	R:R:R183	3.49	No	No	0	2	4
107	R:R:E113	R:R:L184	5.3	No	No	0	2	5
108	R:R:I119	R:R:M115	5.83	No	No	0	5	6
109	R:R:C116	R:R:C194	7.28	No	Yes	2	9	9
110	R:R:A182	R:R:T117	5.03	No	No	0	4	6
111	R:R:A182	R:R:T120	5.03	No	Yes	0	4	5
112	R:R:C194	R:R:T120	3.38	Yes	Yes	0	9	5
113	R:R:D123	R:R:Y301	10.34	Yes	Yes	1	6	7
114	R:R:A124	R:R:V178	5.09	No	No	0	4	5
115	R:R:N125	R:R:T129	4.39	Yes	Yes	4	5	7
116	R:R:N125	R:R:W168	4.52	Yes	No	4	5	9
117	R:R:N125	R:R:S171	8.94	Yes	No	4	5	8
118	R:R:F172	R:R:N125	10.87	No	Yes	0	4	5
119	R:R:I175	R:R:N125	5.66	No	Yes	0	7	5
120	R:R:Q127	R:R:W269	13.14	Yes	Yes	1	8	8
121	R:R:Q127	R:R:Y273	5.64	Yes	Yes	1	8	8
122	R:R:F128	R:R:Y132	10.32	Yes	Yes	4	6	6
123	R:R:F128	R:R:S174	7.93	Yes	No	4	6	5
124	R:R:F128	R:R:Q212	3.51	Yes	No	0	6	5
125	R:R:A216	R:R:F128	5.55	No	Yes	0	5	6
126	R:R:T129	R:R:W168	10.92	Yes	No	4	7	9
127	R:R:S171	R:R:T129	6.4	No	Yes	4	8	7
128	R:R:P220	R:R:T131	3.5	No	No	0	9	8
129	R:R:F265	R:R:T131	5.19	Yes	No	0	9	8
130	R:R:L167	R:R:Y132	3.52	No	Yes	0	7	6
131	R:R:S174	R:R:Y132	5.09	No	Yes	4	5	6
132	R:R:L215	R:R:Y132	3.52	No	Yes	0	4	6
133	R:R:I224	R:R:L134	4.28	No	No	0	8	8
134	R:R:F265	R:R:L134	4.87	Yes	No	0	9	8
135	R:R:P220	R:R:T135	3.5	No	No	0	9	7
136	R:R:I224	R:R:T135	6.08	No	No	0	8	7
137	R:R:M137	R:R:R141	9.93	No	No	0	9	9
138	R:R:A138	R:R:Y228	4	No	Yes	0	9	9
139	R:R:D140	R:R:R155	13.1	No	No	0	8	6
140	R:R:R141	R:R:Y228	8.23	No	Yes	0	9	9
141	R:R:L143	R:R:Y142	3.52	No	Yes	0	4	8
142	R:R:V146	R:R:Y142	15.14	No	Yes	5	7	8
143	R:R:H147	R:R:Y142	6.53	Yes	Yes	5	6	8
144	R:R:R230	R:R:Y142	5.14	No	Yes	0	4	8
145	R:R:A144	R:R:R155	6.91	No	No	0	8	6
146	R:R:I231	R:R:T145	6.08	No	No	0	8	9
147	R:R:H147	R:R:V146	6.92	Yes	No	5	6	7
148	R:R:R234	R:R:V146	9.15	No	No	0	6	7
149	R:R:H147	R:R:S150	4.18	Yes	No	0	6	5
150	R:R:R155	R:R:S151	5.27	No	No	0	6	6
151	R:R:P177	R:R:T176	3.5	No	No	0	8	4
152	R:R:T176	R:R:W179	3.64	No	No	0	4	4
153	R:R:P177	R:R:W207	5.4	No	No	0	8	5
154	R:R:P177	R:R:Y211	11.13	No	No	0	8	3
155	R:R:L180	R:R:W179	10.25	No	No	0	5	4
156	R:R:L180	R:R:Y181	4.69	No	No	0	5	5
157	R:R:L198	R:R:Y181	4.69	No	No	3	5	5
158	R:R:P199	R:R:Y181	13.91	No	No	3	4	5
159	R:R:I185	R:R:P186	3.39	Yes	No	0	2	2
160	R:R:G195	R:R:I185	3.53	No	Yes	0	3	2
161	R:R:I185	R:R:R197	3.76	Yes	No	0	2	3
162	R:R:F187	R:R:P188	4.33	Yes	No	0	1	3
163	R:R:F208	R:R:I196	3.77	Yes	No	3	5	4
164	R:R:L198	R:R:P199	3.28	No	No	3	5	4
165	R:R:F208	R:R:L198	4.87	Yes	No	3	5	5
166	R:R:D204	R:R:P199	4.83	Yes	No	0	2	4
167	R:R:D204	R:R:N200	13.46	Yes	No	0	2	4
168	R:R:D204	R:R:T203	4.34	Yes	No	0	2	3
169	R:R:D204	R:R:W207	8.93	Yes	No	0	2	5
170	R:R:L280	R:R:Y206	3.52	No	No	0	5	3
171	R:R:F208	R:R:W207	4.01	Yes	No	0	5	5
172	R:R:F208	R:R:Q212	10.54	Yes	No	0	5	5
173	R:R:L280	R:R:T209	7.37	No	No	0	5	5
174	R:R:Q212	R:R:Y211	11.27	No	No	0	5	3
175	R:R:F213	R:R:F217	7.5	Yes	No	1	5	8
176	R:R:A218	R:R:F213	4.16	No	Yes	0	5	5
177	R:R:F213	R:R:Y273	5.16	Yes	Yes	1	5	8
178	R:R:F213	R:R:L277	6.09	Yes	No	0	5	6
179	R:R:F214	R:R:L215	3.65	No	No	0	4	4
180	R:R:F214	R:R:L219	9.74	No	No	0	4	5
181	R:R:F217	R:R:Y273	12.38	No	Yes	1	8	8
182	R:R:L219	R:R:P220	3.28	No	No	0	5	9
183	R:R:F221	R:R:T225	7.78	No	No	0	6	5
184	R:R:F221	R:R:F265	7.5	No	Yes	0	6	9
185	R:R:F221	R:R:F266	12.86	No	No	0	6	6
186	R:R:C262	R:R:T225	3.38	No	No	0	8	5
187	R:R:A258	R:R:Y228	4	No	Yes	0	8	9
188	R:R:I261	R:R:Y228	13.3	No	Yes	0	8	9
189	R:R:C262	R:R:Y228	5.38	No	Yes	0	8	9
190	R:R:Q233	R:R:R230	8.18	No	No	0	3	4
191	R:R:R230	R:R:R234	6.4	No	No	0	4	6
192	R:R:L232	R:R:T255	7.37	No	No	0	5	6
193	R:R:A258	R:R:L232	4.73	No	No	0	8	5
194	R:R:M235	R:R:T251	7.53	No	No	0	8	7
195	R:R:M235	R:R:V254	7.61	No	No	0	8	7
196	R:R:R250	R:R:T236	3.88	No	No	0	6	4
197	R:R:P241	R:R:Q244	7.9	No	No	0	3	4
198	R:R:I247	R:R:P241	5.08	Yes	No	0	4	3
199	R:R:Q244	R:R:S246	7.22	No	No	0	4	4
200	R:R:I247	R:R:R250	5.01	Yes	No	0	4	6
201	R:R:K252	R:R:R248	4.95	No	No	0	5	4
202	R:R:L249	R:R:R253	15.79	No	No	0	4	7
203	R:R:E316	R:R:R253	6.98	No	No	0	5	7
204	R:R:L314	R:R:T257	8.84	No	No	0	7	8
205	R:R:L306	R:R:V264	4.47	No	No	0	6	6
206	R:R:F265	R:R:W269	6.01	Yes	Yes	0	9	8
207	R:R:A270	R:R:F266	8.32	No	No	0	5	6
208	R:R:C268	R:R:N303	4.72	No	No	0	8	9
209	R:R:W269	R:R:Y272	5.79	Yes	Yes	1	8	7
210	R:R:W269	R:R:Y273	3.86	Yes	Yes	1	8	8
211	R:R:G300	R:R:W269	8.44	No	Yes	0	7	8
212	R:R:N303	R:R:W269	14.69	No	Yes	0	9	8
213	R:R:Y272	R:R:Y273	13.9	Yes	Yes	1	7	8
214	R:R:Q276	R:R:Y272	12.4	Yes	Yes	1	5	7
215	R:R:F289	R:R:L275	3.65	No	Yes	0	4	4
216	R:R:L275	R:R:Y293	4.69	Yes	Yes	0	4	3
217	R:R:Q276	R:R:Q279	5.12	Yes	No	1	5	3
218	R:R:Q276	R:R:Y293	7.89	Yes	Yes	1	5	3
219	R:R:F289	R:R:Q279	4.68	No	No	0	4	3
220	R:R:Q279	R:R:Y293	11.27	No	Yes	1	3	3
221	R:R:P285	R:R:R284	4.32	No	No	0	1	2
222	R:R:T286	R:R:T288	6.28	No	No	0	1	3
223	R:R:L287	R:R:Y291	3.52	No	No	0	2	3
224	R:R:I297	R:R:Y293	4.84	No	Yes	0	5	3
225	R:R:N303	R:R:N307	12.26	No	No	0	9	9
226	R:R:C315	R:R:Y311	6.72	No	No	0	8	9
227	R:R:F318	R:R:Y311	18.57	No	No	0	8	9
228	R:R:F318	R:R:I312	5.02	No	Yes	0	8	7
229	R:R:E316	R:R:T317	4.23	No	No	0	5	6
230	R:R:K320	R:R:L324	8.46	No	No	0	5	4
231	R:R:S171	R:R:S174	3.26	No	No	4	8	5
232	R:R:A124	R:R:I175	3.25	No	No	0	4	7
233	R:R:A240	R:R:I247	3.25	No	Yes	0	4	4
234	R:R:S298	R:R:V46	3.23	No	No	0	5	5
235	R:R:S69	R:R:V66	3.23	No	No	0	6	3
236	R:R:R253	R:R:R256	3.2	No	No	0	7	7
237	R:R:T135	R:R:V223	3.17	No	No	0	7	6
238	R:R:I62	R:R:S86	3.1	No	No	0	7	9
239	R:R:I282	R:R:S281	3.1	No	No	0	3	4
240	R:R:I312	R:R:V61	3.07	Yes	No	0	7	9
241	R:R:I139	R:R:V223	3.07	No	No	0	6	6
242	R:R:K67	R:R:S325	3.06	No	No	0	5	7
243	R:R:K156	R:R:S158	3.06	No	No	0	7	4
244	R:R:I312	R:R:T60	3.04	Yes	No	0	7	5
245	R:R:I80	R:R:T161	3.04	No	No	0	6	4
246	R:R:F187	R:R:G193	3.01	Yes	No	0	1	5
247	R:R:L143	R:R:S151	3	No	No	0	4	6
248	R:R:L91	R:R:V87	2.98	No	No	0	6	6
249	R:R:L167	R:R:V163	2.98	No	No	0	7	6
250	R:R:L263	R:R:V267	2.98	No	No	0	5	6
251	R:R:N294	R:R:V290	2.96	No	No	0	4	3
252	R:R:I50	R:R:M96	2.92	No	Yes	0	7	7
253	R:R:I55	R:R:L94	2.85	No	No	0	6	5
254	R:R:L118	R:R:M115	2.83	No	No	0	4	6
255	R:R:Q276	R:R:T209	2.83	Yes	No	0	5	5
256	R:R:G112	R:R:W109	2.81	No	Yes	0	7	8
257	L:L:L5	R:R:L287	2.77	No	No	0	0	2
258	R:R:A64	R:R:F318	2.77	No	No	0	7	8
259	R:R:L90	R:R:N58	2.75	No	No	0	8	9
260	R:R:F154	R:R:S151	2.64	No	No	0	4	6
261	R:R:A121	R:R:W179	2.59	No	No	0	5	4
262	R:R:R248	R:R:T251	2.59	No	No	0	4	7
263	R:R:M235	R:R:R250	2.48	No	No	0	8	6
264	R:R:L314	R:R:R256	2.43	No	No	0	7	7
265	R:R:I231	R:R:Y228	2.42	No	Yes	0	8	9
266	R:R:H72	R:R:W73	2.12	No	No	0	7	4
267	R:R:G189	R:R:G190	2.11	No	No	0	3	4
268	R:R:G95	R:R:P97	2.03	No	No	0	6	8
269	R:R:A270	R:R:P271	1.87	No	No	0	5	9
270	R:R:G193	R:R:V192	1.84	No	No	0	5	4
271	R:R:A302	R:R:C268	1.81	No	No	0	5	8
272	R:R:A138	R:R:A227	1.79	No	No	0	9	7
273	R:R:P157	R:R:V77	1.77	No	Yes	0	1	6
274	R:R:G57	R:R:I56	1.76	No	No	0	7	4
275	R:R:C74	R:R:V65	1.71	No	No	0	8	7
276	R:R:C268	R:R:V264	1.71	No	No	0	8	6
277	R:R:A295	R:R:S298	1.71	No	No	0	5	5
278	R:R:A191	R:R:V108	1.7	No	No	0	1	5
279	R:R:A260	R:R:V310	1.7	No	No	0	6	8
280	R:R:I149	R:R:P148	1.69	No	No	0	5	8
281	R:R:C165	R:R:T161	1.69	No	No	0	4	4
282	R:R:I282	R:R:P285	1.69	No	No	0	3	1
283	R:R:C315	R:R:T317	1.69	No	No	0	8	6
284	R:R:K156	R:R:P157	1.67	No	No	0	7	1
285	R:R:L299	R:R:P271	1.64	No	No	0	8	9
286	R:R:N200	R:R:P201	1.63	No	No	0	4	3
287	R:R:S237	R:R:S238	1.63	No	No	0	4	6
288	R:R:S45	R:R:V46	1.62	No	No	0	4	5
289	R:R:S158	R:R:V159	1.62	No	No	0	4	4
290	R:R:S238	R:R:V239	1.62	No	No	0	6	3
291	R:R:A242	R:R:I247	1.62	No	Yes	0	4	4
292	R:R:V264	R:R:V310	1.6	No	No	0	6	8
293	R:R:T225	R:R:V229	1.59	No	No	0	5	4
294	R:R:T278	R:R:V274	1.59	No	No	0	4	6
295	R:R:A169	R:R:L166	1.58	No	No	0	4	4
296	R:R:A296	R:R:L275	1.58	No	Yes	0	6	4
297	R:R:T251	R:R:T255	1.57	No	No	0	7	6
298	R:R:I42	R:R:S45	1.55	No	No	0	6	4
299	R:R:I55	R:R:S59	1.55	No	No	0	6	3
300	R:R:I62	R:R:V87	1.54	No	No	0	7	6
301	R:R:I312	R:R:V313	1.54	Yes	No	0	7	7
302	R:R:H147	R:R:P148	1.53	Yes	No	0	6	8
303	R:R:I259	R:R:T255	1.52	No	No	0	5	6
304	R:R:I282	R:R:T278	1.52	No	No	0	3	4
305	R:R:M115	R:R:T114	1.51	No	No	0	6	3
306	R:R:L71	R:R:V66	1.49	No	No	0	8	3
307	R:R:L287	R:R:T286	1.47	No	No	0	2	1
308	R:R:L210	R:R:L277	1.38	No	No	0	4	6
309	R:R:L275	R:R:L292	1.38	Yes	No	0	4	5
310	L:L:D1	R:R:N40	1.35	No	No	0	0	4
311	R:R:R319	R:R:V313	1.31	No	No	0	8	7
312	R:R:F154	R:R:K153	1.24	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F2	7.65	4	2	0
2	L:L:R6	11.16	4	2	0
3	L:L:L9	5.4525	4	3	0
4	L:L:R11	8.02	6	1	0
5	L:L:Y13	9.786	5	2	0
6	R:R:M43	5.8875	4	1	5
7	R:R:F47	6.2975	4	1	7
8	R:R:V77	3.6925	4	0	6
9	R:R:F81	6.5525	4	0	7
10	R:R:D89	7.56	5	0	9
11	R:R:F92	7.98667	6	1	7
12	R:R:M96	7.04833	6	1	7
13	R:R:W109	8.06375	8	2	8
14	R:R:T120	4.4225	4	0	5
15	R:R:D123	10.5725	4	1	6
16	R:R:N125	6.876	5	4	5
17	R:R:Q127	9.0775	4	1	8
18	R:R:F128	6.8275	4	4	6
19	R:R:T129	7.41	4	4	7
20	R:R:Y132	5.6125	4	4	6
21	R:R:Y142	7.5825	4	5	8
22	R:R:H147	4.79	4	5	6
23	R:R:I185	4.3625	4	0	2
24	R:R:F187	9.195	4	2	1
25	R:R:C194	7.7275	4	2	9
26	R:R:D204	7.89	4	0	2
27	R:R:F208	6.1	5	3	5
28	R:R:F213	5.7275	4	1	5
29	R:R:Y228	6.22167	6	0	9
30	R:R:I247	3.74	4	0	4
31	R:R:F265	5.8925	4	0	9
32	R:R:W269	8.655	6	1	8
33	R:R:Y272	9.8225	4	1	7
34	R:R:Y273	8.188	5	1	8
35	R:R:L275	2.825	4	0	4
36	R:R:Q276	6.634	5	1	5
37	R:R:Y293	8.132	5	1	3
38	R:R:Y301	12.825	4	1	7
39	R:R:I312	3.1675	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R6	L:L:Y13	11.1367	12.35	Yes	Yes	2	0	0
2	L:L:L9	R:R:F208	11.5796	7.31	Yes	Yes	3	0	5
3	R:R:F208	R:R:Q212	24.0135	10.54	Yes	No	0	5	5
4	R:R:F128	R:R:Q212	29.8378	3.51	Yes	No	0	6	5
5	R:R:F128	R:R:Y132	30.6431	10.32	Yes	Yes	4	6	6
6	R:R:L215	R:R:Y132	43.7356	3.52	No	Yes	0	4	6
7	R:R:F214	R:R:L215	44.5553	3.65	No	No	0	4	4
8	R:R:F214	R:R:L219	45.3693	9.74	No	No	0	4	5
9	R:R:L219	R:R:P220	46.1775	3.28	No	No	0	5	9
10	R:R:P220	R:R:T131	49.0422	3.5	No	No	0	9	8
11	R:R:F265	R:R:T131	49.8159	5.19	Yes	No	0	9	8
12	R:R:F265	R:R:W269	100	6.01	Yes	Yes	0	9	8
13	R:R:W269	R:R:Y272	45.2974	5.79	Yes	Yes	1	8	7
14	R:R:Q276	R:R:Y272	24.6232	12.4	Yes	Yes	1	5	7
15	R:R:Q276	R:R:Y293	20.3463	7.89	Yes	Yes	1	5	3
16	L:L:M8	R:R:Y293	22.0174	11.97	No	Yes	0	0	3
17	L:L:M8	L:L:Y13	21.5198	5.99	No	Yes	0	0	0
18	L:L:R11	R:R:D123	26.0815	8.34	Yes	Yes	1	0	6
19	R:R:C194	R:R:T120	25.4113	3.38	Yes	Yes	0	9	5
20	R:R:M99	R:R:T120	39.0043	4.52	No	Yes	0	6	5
21	R:R:D123	R:R:M99	40.4136	15.25	Yes	No	0	6	6
22	L:L:R11	R:R:Q127	23.2196	12.85	Yes	Yes	1	0	8
23	L:L:R11	R:R:Y301	20.8669	6.17	Yes	Yes	1	0	7
24	L:L:V12	R:R:T120	10.6161	4.76	No	Yes	0	0	5
25	R:R:M96	R:R:Y301	31.2155	20.35	Yes	Yes	1	7	7
26	R:R:F47	R:R:M96	17.4845	4.98	Yes	Yes	1	7	7
27	R:R:F221	R:R:F265	77.9596	7.5	No	Yes	0	6	9
28	R:R:F221	R:R:T225	75.1841	7.78	No	No	0	6	5
29	R:R:C262	R:R:T225	74.0336	3.38	No	No	0	8	5
30	R:R:C262	R:R:Y228	73.4468	5.38	No	Yes	0	8	9
31	R:R:R141	R:R:Y228	58.4733	8.23	No	Yes	0	9	9
32	R:R:M137	R:R:R141	57.7514	9.93	No	No	0	9	9
33	R:R:I82	R:R:M137	22.3366	4.37	No	No	0	8	9
34	R:R:I82	R:R:Y311	21.3558	12.09	No	No	0	8	9
35	R:R:F318	R:R:Y311	12.4942	18.57	No	No	0	8	9
36	R:R:F318	R:R:I312	10.5758	5.02	No	Yes	0	8	7
37	R:R:F81	R:R:M137	39.8326	6.22	Yes	No	0	7	9
38	R:R:D140	R:R:F81	36.3553	9.55	No	Yes	0	8	7
39	R:R:D140	R:R:V77	20.5563	4.38	No	Yes	0	8	6
40	R:R:P78	R:R:V77	11.525	3.53	No	Yes	0	8	6
41	R:R:N76	R:R:P78	10.4924	14.66	No	No	0	8	8
42	R:R:S174	R:R:Y132	10.596	5.09	No	Yes	4	5	6
43	R:R:S171	R:R:S174	10.5816	3.26	No	No	4	8	5
44	R:R:N303	R:R:W269	15.6264	14.69	No	Yes	0	9	8
45	R:R:I119	R:R:W109	11.2431	5.87	No	Yes	0	5	8
46	R:R:D140	R:R:R155	16.7482	13.1	No	No	0	8	6
47	R:R:R155	R:R:S151	14.7348	5.27	No	No	0	6	6
48	R:R:L143	R:R:S151	11.6717	3	No	No	0	4	6
49	R:R:L143	R:R:Y142	10.6391	3.52	No	Yes	0	4	8
50	R:R:A258	R:R:Y228	17.6714	4	No	Yes	0	8	9
51	R:R:A258	R:R:L232	16.6705	4.73	No	No	0	8	5
52	R:R:L232	R:R:T255	15.661	7.37	No	No	0	5	6
53	R:R:T251	R:R:T255	13.6361	1.57	No	No	0	7	6
54	R:R:M235	R:R:T251	10.6276	7.53	No	No	0	8	7
55	R:R:Q127	R:R:W269	45.8007	13.14	Yes	Yes	1	8	8
56	L:L:R11	R:R:Y272	24.1918	7.2	Yes	Yes	1	0	7
57	R:R:F92	R:R:Q127	24.419	4.68	Yes	Yes	1	7	8
58	R:R:D123	R:R:F92	14.3897	8.36	Yes	Yes	1	6	7
59	R:R:F92	R:R:Y301	10.5442	14.44	Yes	Yes	1	7	7
60	R:R:C194	R:R:W109	21.2696	15.67	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F2	R:R:N106	4.83	2	Yes	No	0	4	0	1
L:L:F2	R:R:G107	9.03	2	Yes	No	0	4	0	1
L:L:M4	R:R:Y291	4.79	0	No	No	0	3	0	1
L:L:R6	R:R:G107	4.5	2	Yes	No	0	4	0	1
L:L:R6	R:R:F187	16.03	2	Yes	Yes	0	1	0	1
L:L:C7	R:R:P285	3.77	0	No	No	0	1	0	1
L:L:M8	R:R:Y293	11.97	0	No	Yes	0	3	0	1
L:L:L9	R:R:I196	4.28	3	Yes	No	0	4	0	1
L:L:L9	R:R:L205	4.15	3	Yes	No	0	5	0	1
L:L:L9	R:R:F208	7.31	3	Yes	Yes	0	5	0	1
L:L:G10	R:R:Q276	4.93	0	No	Yes	0	5	0	1
L:L:R11	R:R:F92	8.55	1	Yes	Yes	0	7	0	1
L:L:R11	R:R:D123	8.34	1	Yes	Yes	0	6	0	1
L:L:R11	R:R:Q127	12.85	1	Yes	Yes	0	8	0	1
L:L:R11	R:R:Y272	7.2	1	Yes	Yes	0	7	0	1
L:L:R11	R:R:I297	5.01	1	Yes	No	0	5	0	1
L:L:R11	R:R:Y301	6.17	1	Yes	Yes	0	7	0	1
L:L:V12	R:R:T120	4.76	0	No	Yes	0	5	0	1
L:L:V12	R:R:G195	3.68	0	No	No	0	3	0	1
L:L:Y13	R:R:Q102	10.15	2	Yes	No	0	5	0	1
L:L:Y13	R:R:L103	7.03	2	Yes	No	0	4	0	1
L:L:Y13	R:R:F187	13.41	2	Yes	Yes	0	1	0	1
L:L:R14	R:R:L205	4.86	3	No	No	0	5	0	1
L:L:P15	R:R:I185	6.77	0	No	Yes	0	2	0	1
L:L:W17	R:R:P201	9.46	0	No	No	0	3	0	1
L:L:W17	R:R:D202	16.75	0	No	No	0	2	0	1
R:R:I39	R:R:Y291	9.67	0	No	No	3	3	2	1
R:R:I41	R:R:N40	8.5	0	No	No	4	4	2	1
R:R:D123	R:R:F92	8.36	1	Yes	Yes	6	7	1	1
R:R:F92	R:R:S126	5.28	1	Yes	No	7	8	1	2
R:R:F92	R:R:Q127	4.68	1	Yes	Yes	7	8	1	1
R:R:F92	R:R:Y301	14.44	1	Yes	Yes	7	7	1	1
R:R:F92	R:R:S304	6.61	1	Yes	No	7	9	1	2
R:R:M96	R:R:Y301	20.35	1	Yes	Yes	7	7	2	1
R:R:M99	R:R:T120	4.52	0	No	Yes	6	5	2	1
R:R:D123	R:R:M99	15.25	1	Yes	No	6	6	1	2
R:R:Q102	R:R:W109	9.86	2	No	Yes	5	8	1	2
R:R:C194	R:R:Q102	4.58	2	Yes	No	9	5	2	1
R:R:N106	R:R:V108	4.43	0	No	No	4	5	1	2
R:R:C194	R:R:W109	15.67	2	Yes	Yes	9	8	2	2
R:R:A182	R:R:T120	5.03	0	No	Yes	4	5	2	1
R:R:C194	R:R:T120	3.38	2	Yes	Yes	9	5	2	1
R:R:D123	R:R:Y301	10.34	1	Yes	Yes	6	7	1	1
R:R:Q127	R:R:W269	13.14	1	Yes	Yes	8	8	1	2
R:R:Q127	R:R:Y273	5.64	1	Yes	Yes	8	8	1	2
R:R:I185	R:R:P186	3.39	0	Yes	No	2	2	1	2
R:R:G195	R:R:I185	3.53	0	No	Yes	3	2	1	1
R:R:I185	R:R:R197	3.76	0	Yes	No	2	3	1	2
R:R:F187	R:R:P188	4.33	2	Yes	No	1	3	1	2
R:R:F208	R:R:I196	3.77	3	Yes	No	5	4	1	1
R:R:F208	R:R:L198	4.87	3	Yes	No	5	5	1	2
R:R:F208	R:R:W207	4.01	3	Yes	No	5	5	1	2
R:R:F208	R:R:Q212	10.54	3	Yes	No	5	5	1	2
R:R:W269	R:R:Y272	5.79	1	Yes	Yes	8	7	2	1
R:R:W269	R:R:Y273	3.86	1	Yes	Yes	8	8	2	2
R:R:Y272	R:R:Y273	13.9	1	Yes	Yes	7	8	1	2
R:R:Q276	R:R:Y272	12.4	1	Yes	Yes	5	7	1	1
R:R:L275	R:R:Y293	4.69	0	Yes	Yes	4	3	2	1
R:R:Q276	R:R:Q279	5.12	1	Yes	No	5	3	1	2
R:R:Q276	R:R:Y293	7.89	1	Yes	Yes	5	3	1	1
R:R:Q279	R:R:Y293	11.27	1	No	Yes	3	3	2	1
R:R:P285	R:R:R284	4.32	0	No	No	1	2	1	2
R:R:L287	R:R:Y291	3.52	0	No	No	2	3	1	1
R:R:I297	R:R:Y293	4.84	0	No	Yes	5	3	1	1
R:R:F187	R:R:G193	3.01	2	Yes	No	1	5	1	2
R:R:Q276	R:R:T209	2.83	1	Yes	No	5	5	1	2
L:L:L5	R:R:L287	2.77	0	No	No	0	2	0	1
R:R:I282	R:R:P285	1.69	0	No	No	3	1	2	1
R:R:N200	R:R:P201	1.63	0	No	No	4	3	2	1
R:R:L287	R:R:T286	1.47	0	No	No	2	1	1	2
L:L:D1	R:R:N40	1.35	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WWN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	286
Number of Links	312
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	5
Number of Nodes involved in Communities	49
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	55575
Length Of Smallest Path	3
Average Path Length	16.0879
Length of Longest Path	34
Minimum Path Strength	1.425
Average Path Strength	7.07649
Maximum Path Strength	17.395
Minimum Path Correlation	0.7
Average Path Correlation	0.929395
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	47.8922
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.9737
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • neuropeptide binding • peptide binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • melanin-concentrating hormone receptor activity • protein-hormone receptor activity • hormone binding • neuropeptide signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • metabolic process • generation of precursor metabolites and energy • behavior • feeding behavior • ciliary membrane • plasma membrane region • cell projection membrane • melanin-concentrating hormone receptor binding • type 1 melanin-concentrating hormone receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • molecular function activator activity • melanin-concentrating hormone activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission, dopaminergic • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • trans-synaptic signaling • regulation of signaling • regulation of synaptic transmission, dopaminergic • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • synaptic transmission, dopaminergic • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99705
Sequence	>8WWN_nogp_Chain_R Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S K L H W C N N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G N G V W H F G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H P I S S T K F R K P S V A T L V I C L L W A L S F I S I T P V W L Y A R L I P F P G G A V G C G I R L P N P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M T S S V A P A S Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I S R P T L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T F R K R L V L S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	To be published
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	To be published
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	To be published
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	To be published
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	To be published
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	To be published
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	To be published
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	10.1038/s41421-024-00679-8
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	10.1038/s41421-024-00754-0
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	10.1038/s41421-024-00754-0

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