psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C14	L:L:C3	7.28	No	No	0	0	0
2	L:L:F7	L:L:K4	4.96	Yes	Yes	1	0	0
3	L:L:K4	L:L:T12	6.01	Yes	No	0	0	0
4	L:L:K4	R:R:H192	15.72	Yes	No	1	0	4
5	L:L:K4	R:R:R203	6.19	Yes	No	1	0	4
6	L:L:F6	L:L:N5	10.87	No	Yes	2	0	0
7	L:L:N5	R:R:L285	5.49	Yes	Yes	2	0	1
8	L:L:N5	R:R:Y295	3.49	Yes	Yes	2	0	4
9	L:L:F6	R:R:F292	16.08	No	No	0	0	3
10	L:L:F6	R:R:Y295	34.04	No	Yes	2	0	4
11	L:L:F7	L:L:W8	6.01	Yes	Yes	1	0	0
12	L:L:F7	R:R:M193	3.73	Yes	Yes	1	0	4
13	L:L:F7	R:R:W195	9.02	Yes	Yes	1	0	6
14	L:L:F7	R:R:R203	7.48	Yes	No	1	0	4
15	L:L:F7	R:R:F206	7.5	Yes	Yes	1	0	5
16	L:L:F7	R:R:I207	6.28	Yes	Yes	1	0	5
17	L:L:K9	L:L:W8	6.96	Yes	Yes	1	0	0
18	L:L:W8	R:R:Q127	4.38	Yes	Yes	1	0	7
19	L:L:W8	R:R:F206	7.02	Yes	Yes	1	0	5
20	L:L:W8	R:R:T210	6.06	Yes	No	0	0	5
21	L:L:W8	R:R:F273	9.02	Yes	Yes	1	0	6
22	L:L:K9	R:R:L100	4.23	Yes	No	0	0	7
23	L:L:K9	R:R:D123	5.53	Yes	No	1	0	6
24	L:L:K9	R:R:Q127	4.07	Yes	Yes	1	0	7
25	L:L:K9	R:R:F273	6.2	Yes	Yes	1	0	6
26	L:L:K9	R:R:V299	9.11	Yes	No	0	0	5
27	L:L:K9	R:R:Y303	5.97	Yes	Yes	1	0	6
28	L:L:F11	R:R:Q103	7.03	No	Yes	0	0	5
29	L:L:F11	R:R:S107	5.28	No	No	0	0	3
30	L:L:F11	R:R:F292	6.43	No	No	0	0	3
31	L:L:T12	R:R:T190	4.71	No	Yes	0	0	4
32	R:R:I47	R:R:Y51	4.84	No	Yes	4	6	7
33	R:R:F296	R:R:I47	10.05	Yes	No	4	4	6
34	R:R:L97	R:R:Y51	4.69	No	Yes	0	6	7
35	R:R:A101	R:R:Y51	5.34	No	Yes	0	6	7
36	R:R:F296	R:R:Y51	5.16	Yes	Yes	4	4	7
37	R:R:A300	R:R:Y51	5.34	No	Yes	0	4	7
38	R:R:C55	R:R:P98	3.77	No	No	0	6	8
39	R:R:G58	R:R:M94	3.49	No	No	0	8	6
40	R:R:C307	R:R:G58	3.92	No	No	0	7	8
41	R:R:L59	R:R:M94	5.65	No	No	0	7	6
42	R:R:D90	R:R:N62	6.73	Yes	No	0	9	9
43	R:R:N62	R:R:P310	14.66	No	No	0	9	9
44	R:R:F315	R:R:L64	4.87	No	No	0	6	5
45	R:R:P310	R:R:V65	3.53	No	No	0	9	9
46	R:R:F315	R:R:V65	6.55	No	No	0	6	9
47	R:R:I66	R:R:L84	4.28	No	No	0	7	5
48	R:R:R71	R:R:Y67	4.12	No	No	0	5	4
49	R:R:H72	R:R:Y67	10.89	No	No	0	5	4
50	R:R:H72	R:R:V68	5.54	No	No	0	5	7
51	R:R:F324	R:R:H72	16.97	No	No	0	5	5
52	R:R:N80	R:R:S77	7.45	No	No	5	8	8
53	R:R:R155	R:R:S77	5.27	Yes	No	0	7	8
54	R:R:R319	R:R:S77	3.95	No	No	5	6	8
55	R:R:R155	R:R:V78	5.23	Yes	No	0	7	6
56	R:R:R319	R:R:T79	3.88	No	No	0	6	7
57	R:R:N80	R:R:R319	4.82	No	No	5	8	6
58	R:R:V136	R:R:Y82	5.05	No	Yes	0	6	7
59	R:R:M137	R:R:Y82	4.79	No	Yes	0	8	7
60	R:R:D140	R:R:Y82	16.09	No	Yes	0	8	7
61	R:R:A160	R:R:Y82	4	No	Yes	0	7	7
62	R:R:G314	R:R:I83	3.53	No	No	0	7	8
63	R:R:C133	R:R:N85	7.87	No	No	0	7	9
64	R:R:N85	R:R:W168	9.04	No	No	0	9	9
65	R:R:C133	R:R:L86	4.76	No	No	0	7	9
66	R:R:L86	R:R:M137	4.24	No	No	7	9	8
67	R:R:L86	R:R:Y313	3.52	No	Yes	7	9	9
68	R:R:D90	R:R:S306	5.89	Yes	No	0	9	8
69	R:R:D90	R:R:N309	6.73	Yes	No	0	9	9
70	R:R:L92	R:R:N126	12.36	No	No	0	6	8
71	R:R:D123	R:R:F93	9.55	No	Yes	1	6	7
72	R:R:F93	R:R:N126	3.62	Yes	No	0	7	8
73	R:R:F93	R:R:Q127	5.86	Yes	Yes	1	7	7
74	R:R:F93	R:R:Y303	19.6	Yes	Yes	1	7	6
75	R:R:F93	R:R:S306	5.28	Yes	No	0	7	8
76	R:R:M94	R:R:Y303	3.59	No	Yes	0	6	6
77	R:R:L97	R:R:Y303	15.24	No	Yes	0	6	6
78	R:R:F111	R:R:F99	4.29	Yes	No	3	6	5
79	R:R:F99	R:R:M115	3.73	No	No	3	5	5
80	R:R:F99	R:R:V119	11.8	No	No	0	5	5
81	R:R:N104	R:R:Q103	6.6	No	Yes	0	5	5
82	R:R:Q103	R:R:W109	6.57	Yes	Yes	0	5	8
83	R:R:Q103	R:R:S189	4.33	Yes	No	0	5	4
84	R:R:F296	R:R:N104	9.67	Yes	No	0	4	5
85	R:R:P110	R:R:Y108	9.74	No	No	0	2	4
86	R:R:M188	R:R:Y108	5.99	No	No	0	1	4
87	R:R:F111	R:R:W109	23.05	Yes	Yes	3	6	8
88	R:R:C116	R:R:W109	7.84	No	Yes	3	9	8
89	R:R:C191	R:R:W109	18.28	No	Yes	3	9	8
90	R:R:F111	R:R:M115	9.95	Yes	No	3	6	5
91	R:R:S113	R:R:V184	4.85	No	No	0	2	4
92	R:R:C116	R:R:C191	7.28	No	No	3	9	9
93	R:R:R117	R:R:S182	7.91	No	No	0	6	5
94	R:R:N126	R:R:V122	5.91	No	No	0	8	5
95	R:R:D123	R:R:Y303	6.9	No	Yes	1	6	6
96	R:R:G124	R:R:V175	3.68	No	Yes	0	4	7
97	R:R:Q127	R:R:W270	10.95	Yes	Yes	0	7	8
98	R:R:F128	R:R:F132	4.29	No	No	0	6	5
99	R:R:F128	R:R:V174	7.87	No	No	0	6	5
100	R:R:F128	R:R:T210	5.19	No	No	0	6	5
101	R:R:T129	R:R:W168	18.19	No	No	0	7	9
102	R:R:S171	R:R:T129	6.4	No	No	0	8	7
103	R:R:I131	R:R:W270	5.87	No	Yes	0	8	8
104	R:R:F266	R:R:L134	4.87	No	No	0	9	8
105	R:R:P218	R:R:T135	5.25	Yes	No	0	8	7
106	R:R:T135	R:R:V221	4.76	No	No	0	7	6
107	R:R:M137	R:R:Y313	7.18	No	Yes	7	8	9
108	R:R:I222	R:R:S138	4.64	No	No	0	8	9
109	R:R:C225	R:R:S138	5.16	No	No	0	7	9
110	R:R:S138	R:R:Y226	10.17	No	Yes	0	9	8
111	R:R:D140	R:R:W154	8.93	No	No	0	8	2
112	R:R:R141	R:R:Y226	5.14	No	Yes	0	9	8
113	R:R:R141	R:R:Y313	5.14	No	Yes	0	9	9
114	R:R:V146	R:R:Y142	12.62	No	Yes	0	6	8
115	R:R:C225	R:R:Y142	4.03	No	Yes	0	7	8
116	R:R:L228	R:R:Y142	8.21	No	Yes	0	4	8
117	R:R:I229	R:R:Y142	3.63	No	Yes	0	8	8
118	R:R:A144	R:R:W154	6.48	No	No	0	8	2
119	R:R:H147	R:R:V146	4.15	No	No	0	6	6
120	R:R:K232	R:R:V146	4.55	No	No	0	5	6
121	R:R:R150	R:R:T149	3.88	No	No	0	4	5
122	R:R:R150	R:R:R153	5.33	No	No	0	4	4
123	R:R:R155	R:R:W154	10	Yes	No	0	7	2
124	R:R:P158	R:R:T156	3.5	No	No	0	4	7
125	R:R:T156	R:R:V159	6.35	No	Yes	0	7	4
126	R:R:R161	R:R:S164	7.91	No	No	0	3	8
127	R:R:V175	R:R:V178	4.81	Yes	No	0	7	4
128	R:R:F206	R:R:V178	3.93	Yes	No	0	5	4
129	R:R:F181	R:R:V180	5.24	No	No	0	4	4
130	R:R:F181	R:R:M193	3.73	No	Yes	0	4	4
131	R:R:F181	R:R:W202	8.02	No	Yes	0	4	1
132	R:R:P185	R:R:T190	8.74	No	Yes	1	3	4
133	R:R:H192	R:R:P185	6.1	No	No	1	4	3
134	R:R:P185	R:R:Q194	11.05	No	No	0	3	3
135	R:R:R186	R:R:T190	3.88	No	Yes	0	3	4
136	R:R:H192	R:R:T190	5.48	No	Yes	1	4	4
137	R:R:M193	R:R:W195	15.12	Yes	Yes	1	4	6
138	R:R:F206	R:R:M193	6.22	Yes	Yes	1	5	4
139	R:R:P196	R:R:W195	5.4	No	Yes	1	4	6
140	R:R:W195	R:R:W202	7.5	Yes	Yes	1	6	1
141	R:R:R203	R:R:W195	4	No	Yes	1	4	6
142	R:R:F206	R:R:W195	5.01	Yes	Yes	1	5	6
143	R:R:P196	R:R:W202	17.57	No	Yes	1	4	1
144	R:R:P198	R:R:W202	5.4	No	Yes	0	2	1
145	R:R:F206	R:R:I207	6.28	Yes	Yes	1	5	5
146	R:R:I207	R:R:N277	4.25	Yes	No	0	5	6
147	R:R:I207	R:R:V281	4.61	Yes	No	0	5	5
148	R:R:A211	R:R:Y274	4	No	Yes	0	6	8
149	R:R:G214	R:R:P218	4.06	No	Yes	0	5	8
150	R:R:F215	R:R:F216	16.08	No	No	0	8	4
151	R:R:F215	R:R:Y274	5.16	No	Yes	0	8	8
152	R:R:G217	R:R:P218	4.06	No	Yes	0	5	8
153	R:R:F266	R:R:L219	3.65	No	No	0	9	5
154	R:R:V259	R:R:Y226	6.31	No	Yes	0	7	8
155	R:R:V262	R:R:Y226	3.79	No	Yes	0	8	8
156	R:R:V230	R:R:V255	4.81	No	No	0	6	8
157	R:R:R234	R:R:R238	5.33	Yes	No	8	5	6
158	R:R:R234	R:R:S251	7.91	Yes	No	8	5	4
159	R:R:E252	R:R:R234	12.79	No	Yes	0	6	5
160	R:R:R234	R:R:T256	5.17	Yes	No	0	5	6
161	R:R:R238	R:R:R247	18.13	No	Yes	0	6	2
162	R:R:R238	R:R:S251	5.27	No	No	8	6	4
163	R:R:R247	R:R:W241	7	Yes	No	0	2	3
164	R:R:R247	R:R:R248	15.99	Yes	No	0	2	4
165	R:R:R249	R:R:R253	17.06	No	No	0	4	4
166	R:R:R253	R:R:R257	6.4	No	No	0	4	6
167	R:R:M258	R:R:R254	14.89	No	No	0	8	7
168	R:R:L316	R:R:M258	5.65	No	No	0	7	8
169	R:R:V262	R:R:Y313	5.05	No	Yes	0	8	9
170	R:R:L265	R:R:N305	6.87	No	Yes	0	7	9
171	R:R:F266	R:R:W270	6.01	No	Yes	0	9	8
172	R:R:C269	R:R:N305	7.87	No	Yes	0	8	9
173	R:R:W270	R:R:Y274	6.75	Yes	Yes	0	8	8
174	R:R:P302	R:R:W270	13.51	No	Yes	0	7	8
175	R:R:N305	R:R:W270	6.78	Yes	Yes	0	9	8
176	R:R:F273	R:R:Y274	10.32	Yes	Yes	0	6	8
177	R:R:F273	R:R:N277	8.46	Yes	No	0	6	6
178	R:R:L276	R:R:Y295	7.03	No	Yes	0	4	4
179	R:R:L276	R:R:V298	5.96	No	No	0	4	6
180	R:R:L285	R:R:N280	8.24	Yes	No	0	1	4
181	R:R:L285	R:R:P286	4.93	Yes	No	2	1	2
182	R:R:L285	R:R:Y295	7.03	Yes	Yes	2	1	4
183	R:R:E288	R:R:P286	7.86	Yes	No	2	1	2
184	R:R:F291	R:R:P286	5.78	No	No	2	4	2
185	R:R:E288	R:R:F291	11.66	Yes	No	2	1	4
186	R:R:L294	R:R:Y295	9.38	No	Yes	0	5	4
187	R:R:L297	R:R:L301	4.15	No	No	0	5	7
188	R:R:N305	R:R:N309	4.09	Yes	No	0	9	9
189	R:R:N309	R:R:Y313	5.81	No	Yes	0	9	9
190	R:R:L312	R:R:Y313	8.21	No	Yes	0	8	9
191	R:R:F320	R:R:S317	6.61	Yes	No	0	8	8
192	R:R:Q322	R:R:Y318	19.16	No	No	0	4	4
193	R:R:C116	R:R:V184	3.42	No	No	0	9	4
194	R:R:C225	R:R:V139	3.42	No	No	0	7	6
195	R:R:G214	R:R:L213	3.42	No	No	0	5	4
196	R:R:C283	R:R:V282	3.42	No	No	0	3	3
197	R:R:I47	R:R:P48	3.39	No	No	0	6	5
198	R:R:I131	R:R:P218	3.39	No	Yes	0	8	8
199	R:R:A89	R:R:T129	3.36	No	No	0	8	7
200	R:R:M271	R:R:P272	3.35	No	No	0	5	9
201	R:R:L301	R:R:P272	3.28	No	No	0	7	9
202	R:R:A87	R:R:I66	3.25	No	No	0	8	7
203	R:R:A172	R:R:I125	3.25	No	No	0	3	5
204	R:R:V136	R:R:V163	3.21	No	No	6	6	6
205	R:R:V233	R:R:V255	3.21	No	No	0	8	8
206	R:R:C55	R:R:L59	3.17	No	No	0	6	7
207	R:R:T162	R:R:V159	3.17	No	Yes	0	2	4
208	R:R:C223	R:R:L219	3.17	No	No	0	4	5
209	L:L:C14	L:L:N5	3.15	No	Yes	0	0	0
210	R:R:E197	R:R:P198	3.14	No	No	0	3	2
211	R:R:I125	R:R:V175	3.07	No	Yes	0	5	7
212	L:L:C14	R:R:E287	3.04	No	No	0	0	1
213	R:R:I83	R:R:T79	3.04	No	No	0	8	7
214	R:R:M120	R:R:V119	3.04	No	No	0	4	5
215	R:R:G187	R:R:R186	3	No	No	0	4	3
216	R:R:L46	R:R:V42	2.98	No	No	0	4	4
217	R:R:L52	R:R:V56	2.98	No	No	0	4	5
218	R:R:N85	R:R:S164	2.98	No	No	0	9	8
219	R:R:L176	R:R:V180	2.98	No	No	0	4	4
220	R:R:L227	R:R:V231	2.98	No	No	0	3	3
221	R:R:D90	R:R:S130	2.94	Yes	No	0	9	9
222	R:R:N80	R:R:T73	2.92	No	No	0	8	6
223	R:R:F111	R:R:P110	2.89	Yes	No	0	6	2
224	R:R:G112	R:R:W109	2.81	No	Yes	0	7	8
225	R:R:L59	R:R:L95	2.77	No	No	0	7	5
226	R:R:L88	R:R:L92	2.77	No	No	0	6	6
227	R:R:A102	R:R:F111	2.77	No	Yes	0	3	6
228	R:R:L312	R:R:L316	2.77	No	No	0	8	7
229	R:R:E91	R:R:I66	2.73	No	No	0	7	7
230	R:R:R155	R:R:S151	2.64	Yes	No	0	7	5
231	R:R:F320	R:R:V68	2.62	Yes	No	0	8	7
232	R:R:F320	R:R:V69	2.62	Yes	No	0	8	7
233	R:R:R153	R:R:V159	2.62	No	Yes	0	4	4
234	R:R:R234	R:R:V230	2.62	Yes	No	0	5	6
235	R:R:V50	R:R:Y51	2.52	No	Yes	0	5	7
236	R:R:V81	R:R:Y82	2.52	No	Yes	0	6	7
237	R:R:F320	R:R:I83	2.51	Yes	No	0	8	8
238	R:R:K321	R:R:R254	2.48	No	No	0	8	7
239	R:R:L143	R:R:Y142	2.34	No	Yes	0	5	8
240	R:R:L213	R:R:Y209	2.34	No	No	0	4	3
241	R:R:F324	R:R:R325	2.14	No	No	0	5	5
242	R:R:G96	R:R:P98	2.03	No	No	0	6	8
243	R:R:A204	R:R:G205	1.95	No	No	0	2	4
244	R:R:A236	R:R:G237	1.95	No	No	0	6	4
245	R:R:C283	R:R:P284	1.88	No	No	0	3	1
246	R:R:A105	R:R:P48	1.87	No	No	0	4	5
247	R:R:A157	R:R:P158	1.87	No	No	0	1	4
248	R:R:G183	R:R:S182	1.86	No	No	0	4	5
249	R:R:G44	R:R:V45	1.84	No	No	0	4	6
250	R:R:G58	R:R:V57	1.84	No	No	0	8	5
251	R:R:G183	R:R:V184	1.84	No	No	0	4	4
252	R:R:G237	R:R:V240	1.84	No	No	0	4	5
253	R:R:P76	R:R:S75	1.78	No	No	0	6	6
254	R:R:P272	R:R:V298	1.77	No	No	0	9	6
255	R:R:P148	R:R:T149	1.75	No	No	0	8	5
256	R:R:C307	R:R:V54	1.71	No	No	0	7	7
257	R:R:G61	R:R:L60	1.71	No	No	0	7	5
258	R:R:C283	R:R:V279	1.71	No	No	0	3	4
259	R:R:A87	R:R:V65	1.7	No	No	0	8	9
260	R:R:A121	R:R:V179	1.7	No	No	0	5	5
261	R:R:A144	R:R:V145	1.7	No	No	0	8	8
262	R:R:A204	R:R:V281	1.7	No	No	0	2	5
263	R:R:L176	R:R:P177	1.64	No	No	0	4	7
264	R:R:A211	R:R:I278	1.62	No	No	0	6	5
265	R:R:V53	R:R:V57	1.6	No	No	0	5	5
266	R:R:V56	R:R:V57	1.6	No	No	0	5	5
267	R:R:V136	R:R:V167	1.6	No	No	6	6	6
268	R:R:V145	R:R:V233	1.6	No	No	0	8	8
269	R:R:V159	R:R:V163	1.6	Yes	No	0	4	6
270	R:R:V163	R:R:V167	1.6	No	No	6	6	6
271	R:R:V169	R:R:V173	1.6	No	No	0	4	3
272	R:R:V175	R:R:V179	1.6	Yes	No	0	7	5
273	R:R:V230	R:R:V231	1.6	No	No	0	6	3
274	R:R:V259	R:R:V263	1.6	No	No	0	7	7
275	R:R:V262	R:R:V263	1.6	No	No	0	8	7
276	R:R:T256	R:R:V260	1.59	No	No	0	6	5
277	R:R:A308	R:R:L265	1.58	No	No	0	6	7
278	R:R:E288	R:R:P289	1.57	Yes	No	0	1	3
279	R:R:M271	R:R:V275	1.52	No	No	0	5	7
280	L:L:T10	R:R:M120	1.51	No	No	0	0	4
281	R:R:A290	R:R:E288	1.51	No	Yes	0	1	1
282	R:R:F296	R:R:G293	1.51	Yes	No	0	4	3
283	R:R:L60	R:R:S63	1.5	No	No	0	5	4
284	R:R:L49	R:R:V53	1.49	No	No	0	4	5
285	R:R:L285	R:R:V279	1.49	Yes	No	0	1	4
286	R:R:L46	R:R:L49	1.38	No	No	0	4	4
287	R:R:A242	R:R:R247	1.38	No	Yes	0	4	2
288	R:R:A199	R:R:W195	1.3	No	Yes	0	4	6
289	R:R:V240	R:R:W241	1.23	No	No	0	5	3
290	R:R:K321	R:R:Y318	1.19	No	No	0	8	4
291	R:R:L106	R:R:Y108	1.17	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K4	8.22	4	1	0
2	L:L:N5	5.75	4	2	0
3	L:L:F7	6.42571	7	1	0
4	L:L:W8	6.575	6	1	0
5	L:L:K9	6.01	7	1	0
6	R:R:Y51	4.64833	6	4	7
7	R:R:Y82	6.49	5	0	7
8	R:R:D90	5.5725	4	0	9
9	R:R:F93	8.782	5	1	7
10	R:R:Q103	6.1325	4	0	5
11	R:R:W109	11.71	5	3	8
12	R:R:F111	8.59	5	3	6
13	R:R:Q127	6.315	4	1	7
14	R:R:Y142	6.166	5	0	8
15	R:R:R155	5.785	4	0	7
16	R:R:V159	3.435	4	0	4
17	R:R:V175	3.29	4	0	7
18	R:R:T190	5.7025	4	1	4
19	R:R:M193	7.2	4	1	4
20	R:R:W195	6.76429	7	1	6
21	R:R:W202	9.6225	4	1	1
22	R:R:F206	5.99333	6	1	5
23	R:R:I207	5.355	4	1	5
24	R:R:P218	4.19	4	0	8
25	R:R:Y226	6.3525	4	0	8
26	R:R:R234	6.764	5	8	5
27	R:R:R247	10.625	4	0	2
28	R:R:W270	8.31167	6	0	8
29	R:R:F273	8.5	4	1	6
30	R:R:Y274	6.5575	4	0	8
31	R:R:L285	5.436	5	2	1
32	R:R:E288	5.65	4	2	1
33	R:R:Y295	12.194	5	2	4
34	R:R:F296	6.5975	4	4	4
35	R:R:Y303	10.26	5	1	6
36	R:R:N305	6.4025	4	0	9
37	R:R:Y313	5.81833	6	7	9
38	R:R:F320	3.59	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F6	L:L:N5	21.0594	10.87	No	Yes	2	0	0
2	L:L:F6	R:R:F292	50.2439	16.08	No	No	0	0	3
3	L:L:F11	R:R:F292	51.4511	6.43	No	No	0	0	3
4	L:L:F11	R:R:Q103	53.8014	7.03	No	Yes	0	0	5
5	R:R:N104	R:R:Q103	77.5413	6.6	No	Yes	0	5	5
6	R:R:F296	R:R:N104	78.3838	9.67	Yes	No	0	4	5
7	R:R:F296	R:R:Y51	79.3644	5.16	Yes	Yes	4	4	7
8	R:R:L97	R:R:Y51	86.6913	4.69	No	Yes	0	6	7
9	R:R:L97	R:R:Y303	87.5634	15.24	No	Yes	0	6	6
10	L:L:K9	R:R:Y303	39.2116	5.97	Yes	Yes	1	0	6
11	L:L:K9	L:L:W8	25.3511	6.96	Yes	Yes	1	0	0
12	L:L:F7	L:L:W8	33.2939	6.01	Yes	Yes	1	0	0
13	L:L:F7	L:L:K4	14.4962	4.96	Yes	Yes	1	0	0
14	L:L:N5	R:R:L285	15.659	5.49	Yes	Yes	2	0	1
15	L:L:W8	R:R:F206	27.2481	7.02	Yes	Yes	1	0	5
16	L:L:K9	R:R:Q127	10.5051	4.07	Yes	Yes	1	0	7
17	R:R:F93	R:R:Y303	62.0103	19.6	Yes	Yes	1	7	6
18	R:R:F93	R:R:Q127	14.442	5.86	Yes	Yes	1	7	7
19	R:R:M94	R:R:Y303	23.9616	3.59	No	Yes	0	6	6
20	R:R:G58	R:R:M94	15.2698	3.49	No	No	0	8	6
21	R:R:F93	R:R:S306	58.9948	5.28	Yes	No	0	7	8
22	R:R:D90	R:R:S306	58.6598	5.89	Yes	No	0	9	8
23	R:R:D90	R:R:N62	13.3875	6.73	Yes	No	0	9	9
24	R:R:N62	R:R:P310	11.9389	14.66	No	No	0	9	9
25	R:R:P310	R:R:V65	10.4804	3.53	No	No	0	9	9
26	R:R:D90	R:R:N309	56.4917	6.73	Yes	No	0	9	9
27	R:R:N309	R:R:Y313	100	5.81	No	Yes	0	9	9
28	R:R:M137	R:R:Y313	65.287	7.18	No	Yes	7	8	9
29	R:R:M137	R:R:Y82	66.9722	4.79	No	Yes	0	8	7
30	R:R:D140	R:R:Y82	51.934	16.09	No	Yes	0	8	7
31	R:R:D140	R:R:W154	50.8549	8.93	No	No	0	8	2
32	R:R:R155	R:R:W154	25.9325	10	Yes	No	0	7	2
33	R:R:R155	R:R:S77	21.9808	5.27	Yes	No	0	7	8
34	R:R:R319	R:R:S77	17.9699	3.95	No	No	5	6	8
35	R:R:R319	R:R:T79	16.8514	3.88	No	No	0	6	7
36	R:R:I83	R:R:T79	15.4915	3.04	No	No	0	8	7
37	R:R:F320	R:R:I83	12.7125	2.51	Yes	No	0	8	8
38	R:R:V136	R:R:Y82	16.9401	5.05	No	Yes	0	6	7
39	R:R:L86	R:R:Y313	10.4164	3.52	No	Yes	7	9	9
40	R:R:C133	R:R:L86	11.5447	4.76	No	No	0	7	9
41	R:R:C133	R:R:N85	10.1355	7.87	No	No	0	7	9
42	R:R:Q103	R:R:W109	29.4309	6.57	Yes	Yes	0	5	8
43	R:R:F111	R:R:W109	16.6149	23.05	Yes	Yes	3	6	8
44	R:R:Q127	R:R:W270	52.2986	10.95	Yes	Yes	0	7	8
45	R:R:I131	R:R:W270	15.0924	5.87	No	Yes	0	8	8
46	R:R:I131	R:R:P218	13.2397	3.39	No	Yes	0	8	8
47	R:R:R141	R:R:Y313	18.4183	5.14	No	Yes	0	9	9
48	R:R:R141	R:R:Y226	17.2259	5.14	No	Yes	0	9	8
49	R:R:S138	R:R:Y226	29.4999	10.17	No	Yes	0	9	8
50	R:R:V262	R:R:Y313	21.0643	5.05	No	Yes	0	8	9
51	R:R:V262	R:R:Y226	17.2801	3.79	No	Yes	0	8	8
52	R:R:C225	R:R:S138	24.1882	5.16	No	No	0	7	9
53	R:R:C225	R:R:Y142	18.8372	4.03	No	Yes	0	7	8
54	R:R:A144	R:R:W154	27.4403	6.48	No	No	0	8	2
55	R:R:V136	R:R:V163	14.1463	3.21	No	No	6	6	6
56	R:R:V159	R:R:V163	12.9441	1.6	Yes	No	0	4	6
57	R:R:F181	R:R:M193	10.3572	3.73	No	Yes	0	4	4
58	R:R:I207	R:R:V281	11.0076	4.61	Yes	No	0	5	5
59	R:R:A144	R:R:V145	26.1493	1.7	No	No	0	8	8
60	R:R:V145	R:R:V233	24.8386	1.6	No	No	0	8	8
61	R:R:V233	R:R:V255	23.5526	3.21	No	No	0	8	8
62	R:R:V230	R:R:V255	22.3306	4.81	No	No	0	6	8
63	R:R:R234	R:R:V230	18.3149	2.62	Yes	No	0	5	6
64	R:R:R234	R:R:R238	11.3821	5.33	Yes	No	8	5	6
65	R:R:R238	R:R:R247	10.0074	18.13	No	Yes	0	6	2
66	R:R:N305	R:R:W270	49.7216	6.78	Yes	Yes	0	9	8
67	R:R:L276	R:R:Y295	10.2735	7.03	No	Yes	0	4	4
68	R:R:L285	R:R:P286	14.506	4.93	Yes	No	2	1	2
69	R:R:L285	R:R:V279	11.6236	1.49	Yes	No	0	1	4
70	R:R:G58	R:R:V57	10.7908	1.84	No	No	0	8	5
71	L:L:F6	R:R:Y295	27.9478	34.04	No	Yes	2	0	4
72	R:R:L285	R:R:Y295	15.93	7.03	Yes	Yes	2	1	4
73	L:L:W8	R:R:Q127	38.4873	4.38	Yes	Yes	1	0	7
74	R:R:N305	R:R:N309	46.7061	4.09	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K4	R:R:H192	15.72	1	Yes	No	0	4	0	1
L:L:K4	R:R:R203	6.19	1	Yes	No	0	4	0	1
L:L:N5	R:R:L285	5.49	2	Yes	Yes	0	1	0	1
L:L:N5	R:R:Y295	3.49	2	Yes	Yes	0	4	0	1
L:L:F6	R:R:F292	16.08	2	No	No	0	3	0	1
L:L:F6	R:R:Y295	34.04	2	No	Yes	0	4	0	1
L:L:F7	R:R:M193	3.73	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:W195	9.02	1	Yes	Yes	0	6	0	1
L:L:F7	R:R:R203	7.48	1	Yes	No	0	4	0	1
L:L:F7	R:R:F206	7.5	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:I207	6.28	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:Q127	4.38	1	Yes	Yes	0	7	0	1
L:L:W8	R:R:F206	7.02	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:T210	6.06	1	Yes	No	0	5	0	1
L:L:W8	R:R:F273	9.02	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:L100	4.23	1	Yes	No	0	7	0	1
L:L:K9	R:R:D123	5.53	1	Yes	No	0	6	0	1
L:L:K9	R:R:Q127	4.07	1	Yes	Yes	0	7	0	1
L:L:K9	R:R:F273	6.2	1	Yes	Yes	0	6	0	1
L:L:K9	R:R:V299	9.11	1	Yes	No	0	5	0	1
L:L:K9	R:R:Y303	5.97	1	Yes	Yes	0	6	0	1
L:L:F11	R:R:Q103	7.03	0	No	Yes	0	5	0	1
L:L:F11	R:R:S107	5.28	0	No	No	0	3	0	1
L:L:F11	R:R:F292	6.43	0	No	No	0	3	0	1
L:L:T12	R:R:T190	4.71	0	No	Yes	0	4	0	1
R:R:D123	R:R:F93	9.55	1	No	Yes	6	7	1	2
R:R:F93	R:R:Q127	5.86	1	Yes	Yes	7	7	2	1
R:R:F93	R:R:Y303	19.6	1	Yes	Yes	7	6	2	1
R:R:M94	R:R:Y303	3.59	0	No	Yes	6	6	2	1
R:R:L97	R:R:Y303	15.24	0	No	Yes	6	6	2	1
R:R:N104	R:R:Q103	6.6	0	No	Yes	5	5	2	1
R:R:Q103	R:R:W109	6.57	0	Yes	Yes	5	8	1	2
R:R:Q103	R:R:S189	4.33	0	Yes	No	5	4	1	2
R:R:D123	R:R:Y303	6.9	1	No	Yes	6	6	1	1
R:R:Q127	R:R:W270	10.95	1	Yes	Yes	7	8	1	2
R:R:F128	R:R:T210	5.19	0	No	No	6	5	2	1
R:R:F206	R:R:V178	3.93	1	Yes	No	5	4	1	2
R:R:F181	R:R:M193	3.73	0	No	Yes	4	4	2	1
R:R:F181	R:R:W202	8.02	0	No	Yes	4	1	2	2
R:R:P185	R:R:T190	8.74	1	No	Yes	3	4	2	1
R:R:H192	R:R:P185	6.1	1	No	No	4	3	1	2
R:R:R186	R:R:T190	3.88	0	No	Yes	3	4	2	1
R:R:H192	R:R:T190	5.48	1	No	Yes	4	4	1	1
R:R:M193	R:R:W195	15.12	1	Yes	Yes	4	6	1	1
R:R:F206	R:R:M193	6.22	1	Yes	Yes	5	4	1	1
R:R:P196	R:R:W195	5.4	1	No	Yes	4	6	2	1
R:R:W195	R:R:W202	7.5	1	Yes	Yes	6	1	1	2
R:R:R203	R:R:W195	4	1	No	Yes	4	6	1	1
R:R:F206	R:R:W195	5.01	1	Yes	Yes	5	6	1	1
R:R:P196	R:R:W202	17.57	1	No	Yes	4	1	2	2
R:R:F206	R:R:I207	6.28	1	Yes	Yes	5	5	1	1
R:R:I207	R:R:N277	4.25	1	Yes	No	5	6	1	2
R:R:I207	R:R:V281	4.61	1	Yes	No	5	5	1	2
R:R:W270	R:R:Y274	6.75	0	Yes	Yes	8	8	2	2
R:R:F273	R:R:Y274	10.32	1	Yes	Yes	6	8	1	2
R:R:F273	R:R:N277	8.46	1	Yes	No	6	6	1	2
R:R:L276	R:R:Y295	7.03	0	No	Yes	4	4	2	1
R:R:L285	R:R:N280	8.24	2	Yes	No	1	4	1	2
R:R:L285	R:R:P286	4.93	2	Yes	No	1	2	1	2
R:R:L285	R:R:Y295	7.03	2	Yes	Yes	1	4	1	1
R:R:L294	R:R:Y295	9.38	0	No	Yes	5	4	2	1
L:L:C14	R:R:E287	3.04	0	No	No	0	1	0	1
R:R:M120	R:R:V119	3.04	0	No	No	4	5	1	2
L:L:T10	R:R:M120	1.51	0	No	No	0	4	0	1
R:R:L285	R:R:V279	1.49	2	Yes	No	1	4	1	2
R:R:A199	R:R:W195	1.3	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZBI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	266
Number of Links	291
Number of Hubs	38
Number of Links mediated by Hubs	150
Number of Communities	8
Number of Nodes involved in Communities	47
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	44872
Length Of Smallest Path	3
Average Path Length	14.3599
Length of Longest Path	36
Minimum Path Strength	1.435
Average Path Strength	6.92384
Maximum Path Strength	25.06
Minimum Path Correlation	0.7
Average Path Correlation	0.925794
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.6929
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5257
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • hormone activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • response to acid chemical • response to stimulus • response to chemical • response to amino acid • response to xenobiotic stimulus • regulation of postsynaptic membrane neurotransmitter receptor levels • biological regulation • regulation of biological quality • somatostatin signaling pathway • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • response to endogenous stimulus • hormone-mediated signaling pathway • cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • somatostatin receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular response to hormone stimulus • cell-cell signaling • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • response to osmotic stress • hyperosmotic response • response to stress • response to abiotic stimulus • cell surface receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to lipid • response to steroid hormone • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • cell death • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • response to nutrient levels • response to nutrient • response to pH • response to acidic pH • multicellular organismal process • digestion • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • neuronal dense core vesicle • cytosol • GABA-ergic synapse • somatodendritic compartment • cell body • neuronal cell body • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • peptide binding • neuropeptide signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell projection • cilium • plasma membrane bounded cell projection • non-motile cilium • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • neuron projection • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32745
Sequence	>8ZBI_nogp_Chain_R A V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H T A S P S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S Y W P F G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H P T R S A R W R T A P V A R T V S A A V W V A S A V V V L P V V V F S G V P R G M S T C H M Q W P E P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V W A R R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C P L P E E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F K Q G F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XIQ	A	Peptide	Somatostatin	SST3	Homo sapiens	L796778	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.71	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIQ (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	L796778	-		2.71	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIR	A	Peptide	Somatostatin	SST3	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.52	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIR (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	Pasireotide	-		2.52	2024-07-03	doi.org/10.1073/pnas.2400298121
	8ZBI	A	Peptide	Somatostatin	SST3	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.79	2025-04-30	To be published
	8ZBI (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	Somatostatin-14	-		2.79	2025-04-30	To be published

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