psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	13.32	Yes	Yes	1	0	0
2	L:L:?1	L:L:?4	9.18	Yes	Yes	1	0	0
3	L:L:?1	L:L:?6	25.64	Yes	Yes	1	0	0
4	L:L:?1	R:R:H192	6.24	Yes	No	0	0	4
5	L:L:?1	R:R:W195	11.97	Yes	Yes	1	0	6
6	L:L:?1	R:R:R203	11.79	Yes	Yes	1	0	4
7	L:L:?2	L:L:K3	22.39	Yes	Yes	1	0	0
8	L:L:?2	L:L:?4	4.51	Yes	Yes	1	0	0
9	L:L:?2	R:R:Q127	6.34	Yes	Yes	1	0	7
10	L:L:?2	R:R:M193	6.73	Yes	Yes	0	0	4
11	L:L:?2	R:R:T210	4.68	Yes	No	0	0	5
12	L:L:?2	R:R:F273	7.73	Yes	Yes	1	0	6
13	L:L:K3	R:R:D123	12.44	Yes	No	0	0	6
14	L:L:K3	R:R:Q127	4.07	Yes	Yes	1	0	7
15	L:L:K3	R:R:F273	6.2	Yes	Yes	1	0	6
16	L:L:?4	L:L:?6	9.37	Yes	Yes	1	0	0
17	L:L:?4	R:R:L100	14.76	Yes	No	0	0	7
18	L:L:?4	R:R:Q103	9.83	Yes	No	1	0	5
19	L:L:?4	R:R:W109	4.67	Yes	Yes	1	0	8
20	L:L:?4	R:R:V119	13.44	Yes	No	0	0	5
21	L:L:?4	R:R:M120	4.64	Yes	No	0	0	4
22	L:L:?4	R:R:D123	6.68	Yes	No	0	0	6
23	L:L:?6	L:L:F5	25.68	Yes	No	0	0	0
24	L:L:F5	R:R:F292	18.22	No	No	0	0	3
25	L:L:F5	R:R:Y295	17.54	No	No	0	0	4
26	L:L:?6	R:R:E287	6.07	Yes	No	0	0	1
27	R:R:G44	R:R:P48	4.06	No	No	0	4	5
28	R:R:I47	R:R:L46	5.71	No	No	0	6	4
29	R:R:F296	R:R:I47	23.86	Yes	No	0	4	6
30	R:R:N104	R:R:Y51	4.65	No	Yes	2	5	7
31	R:R:F296	R:R:Y51	7.22	Yes	Yes	2	4	7
32	R:R:V299	R:R:Y51	6.31	No	Yes	0	5	7
33	R:R:A300	R:R:Y51	5.34	No	Yes	0	4	7
34	R:R:C55	R:R:M94	4.86	No	Yes	0	6	6
35	R:R:C55	R:R:L97	9.52	No	Yes	0	6	6
36	R:R:G58	R:R:M94	5.24	No	Yes	3	8	6
37	R:R:C307	R:R:G58	3.92	Yes	No	3	7	8
38	R:R:L59	R:R:M94	7.07	No	Yes	0	7	6
39	R:R:L59	R:R:L95	4.15	No	No	0	7	5
40	R:R:G61	R:R:P310	4.06	No	No	0	7	9
41	R:R:D90	R:R:N62	6.73	Yes	No	0	9	9
42	R:R:E91	R:R:N62	10.52	No	No	0	7	9
43	R:R:N62	R:R:P310	6.52	No	No	0	9	9
44	R:R:F315	R:R:L64	4.87	Yes	No	4	6	5
45	R:R:F324	R:R:L64	3.65	No	No	4	5	5
46	R:R:E91	R:R:I66	6.83	No	Yes	0	7	7
47	R:R:R71	R:R:Y67	16.46	No	No	0	5	4
48	R:R:H72	R:R:Y67	4.36	No	No	0	5	4
49	R:R:F324	R:R:V68	17.04	No	No	0	5	7
50	R:R:T73	R:R:V69	4.76	No	No	0	6	7
51	R:R:L84	R:R:V69	5.96	No	No	0	5	7
52	R:R:F320	R:R:V69	3.93	Yes	No	0	8	7
53	R:R:H72	R:R:V327	8.3	No	No	0	5	5
54	R:R:N80	R:R:T73	4.39	Yes	No	0	8	6
55	R:R:P76	R:R:S77	3.56	No	No	0	6	8
56	R:R:N80	R:R:P76	13.03	Yes	No	0	8	6
57	R:R:V78	R:R:Y82	12.62	Yes	Yes	1	6	7
58	R:R:D140	R:R:V78	4.38	No	Yes	1	8	6
59	R:R:R155	R:R:V78	7.85	Yes	Yes	1	7	6
60	R:R:N80	R:R:R319	4.82	Yes	No	5	8	6
61	R:R:F320	R:R:N80	12.08	Yes	Yes	5	8	8
62	R:R:A160	R:R:V81	5.09	No	No	0	7	6
63	R:R:R161	R:R:V81	5.23	No	No	0	3	6
64	R:R:V136	R:R:Y82	8.83	No	Yes	0	6	7
65	R:R:M137	R:R:Y82	4.79	Yes	Yes	1	8	7
66	R:R:D140	R:R:Y82	9.2	No	Yes	1	8	7
67	R:R:V163	R:R:Y82	5.05	No	Yes	0	6	7
68	R:R:I83	R:R:M137	4.37	No	Yes	0	8	8
69	R:R:F320	R:R:I83	10.05	Yes	No	0	8	8
70	R:R:C133	R:R:N85	6.3	No	No	0	7	9
71	R:R:N85	R:R:S164	7.45	No	No	0	9	8
72	R:R:N85	R:R:W168	7.91	No	No	0	9	9
73	R:R:D90	R:R:L86	8.14	Yes	Yes	1	9	9
74	R:R:C133	R:R:L86	6.35	No	Yes	0	7	9
75	R:R:L134	R:R:L86	6.92	No	Yes	1	8	9
76	R:R:L86	R:R:N309	4.12	Yes	Yes	1	9	9
77	R:R:D90	R:R:S130	4.42	Yes	No	0	9	9
78	R:R:D90	R:R:S306	11.78	Yes	No	0	9	8
79	R:R:D90	R:R:N309	4.04	Yes	Yes	1	9	9
80	R:R:L92	R:R:N126	10.98	No	Yes	0	6	8
81	R:R:F93	R:R:Q127	7.03	No	Yes	0	7	7
82	R:R:F93	R:R:Y303	14.44	No	No	0	7	6
83	R:R:C307	R:R:M94	4.86	Yes	Yes	3	7	6
84	R:R:L97	R:R:P98	4.93	Yes	No	0	6	8
85	R:R:L100	R:R:L97	4.15	No	Yes	0	7	6
86	R:R:L97	R:R:Y303	9.38	Yes	No	0	6	6
87	R:R:F99	R:R:W109	5.01	No	Yes	0	5	8
88	R:R:F99	R:R:V119	5.24	No	No	0	5	5
89	R:R:Q103	R:R:W109	4.38	No	Yes	1	5	8
90	R:R:F296	R:R:N104	9.67	Yes	No	2	4	5
91	R:R:P110	R:R:Y108	5.56	No	No	0	2	4
92	R:R:S189	R:R:Y108	6.36	No	No	0	4	4
93	R:R:F111	R:R:W109	10.02	No	Yes	0	6	8
94	R:R:C116	R:R:W109	7.84	No	Yes	1	9	8
95	R:R:C191	R:R:W109	11.75	No	Yes	1	9	8
96	R:R:F111	R:R:P110	4.33	No	No	0	6	2
97	R:R:F111	R:R:M115	3.73	No	No	0	6	5
98	R:R:C116	R:R:V184	5.12	No	No	0	9	4
99	R:R:C116	R:R:C191	7.28	No	No	1	9	9
100	R:R:R117	R:R:S182	5.27	No	No	0	6	5
101	R:R:M120	R:R:S182	6.13	No	No	0	4	5
102	R:R:M120	R:R:M193	8.66	No	Yes	0	4	4
103	R:R:N126	R:R:V122	5.91	Yes	No	0	8	5
104	R:R:D123	R:R:G124	5.03	No	No	0	6	4
105	R:R:I131	R:R:Q127	4.12	No	Yes	1	8	7
106	R:R:Q127	R:R:W270	10.95	Yes	Yes	1	7	8
107	R:R:Q127	R:R:Y274	7.89	Yes	Yes	1	7	8
108	R:R:F128	R:R:F132	7.5	No	Yes	6	6	5
109	R:R:F128	R:R:V174	14.42	No	No	6	6	5
110	R:R:F128	R:R:V175	5.24	No	No	0	6	7
111	R:R:T129	R:R:W168	15.77	No	No	0	7	9
112	R:R:S171	R:R:T129	7.99	No	No	0	8	7
113	R:R:I131	R:R:W270	9.4	No	Yes	1	8	8
114	R:R:F132	R:R:V167	6.55	Yes	No	0	5	6
115	R:R:F132	R:R:S171	6.61	Yes	No	0	5	8
116	R:R:F132	R:R:V174	3.93	Yes	No	6	5	5
117	R:R:L134	R:R:N309	12.36	No	Yes	1	8	9
118	R:R:L134	R:R:Y313	8.21	No	No	1	8	9
119	R:R:M137	R:R:R141	7.44	Yes	Yes	1	8	9
120	R:R:M137	R:R:Y313	5.99	Yes	No	1	8	9
121	R:R:I222	R:R:S138	9.29	No	No	0	8	9
122	R:R:C225	R:R:S138	6.89	No	No	0	7	9
123	R:R:D140	R:R:R155	7.15	No	Yes	1	8	7
124	R:R:R141	R:R:Y226	9.26	Yes	Yes	1	9	8
125	R:R:R141	R:R:Y262	5.14	Yes	Yes	1	9	8
126	R:R:R141	R:R:Y313	8.23	Yes	No	1	9	9
127	R:R:V146	R:R:Y142	12.62	No	Yes	7	6	8
128	R:R:H147	R:R:Y142	4.36	No	Yes	7	6	8
129	R:R:C225	R:R:Y142	5.38	No	Yes	0	7	8
130	R:R:L228	R:R:Y142	8.21	No	Yes	0	4	8
131	R:R:I229	R:R:Y142	3.63	No	Yes	0	8	8
132	R:R:I229	R:R:V145	10.75	No	No	0	8	8
133	R:R:H147	R:R:V146	12.45	No	No	7	6	6
134	R:R:H147	R:R:R150	24.83	No	No	0	6	4
135	R:R:R150	R:R:W154	13	No	No	0	4	2
136	R:R:R155	R:R:S151	6.59	Yes	No	0	7	5
137	R:R:T156	R:R:V159	4.76	No	No	0	7	4
138	R:R:M193	R:R:V178	9.13	Yes	No	0	4	4
139	R:R:F181	R:R:V180	3.93	No	No	0	4	4
140	R:R:F181	R:R:P196	10.11	No	No	0	4	4
141	R:R:P185	R:R:V184	5.3	No	No	0	3	4
142	R:R:Q194	R:R:R186	18.69	No	No	0	3	3
143	R:R:H192	R:R:T190	15.06	No	No	0	4	4
144	R:R:M193	R:R:W195	5.82	Yes	Yes	0	4	6
145	R:R:R203	R:R:W195	8	Yes	Yes	1	4	6
146	R:R:F206	R:R:W195	6.01	No	Yes	0	5	6
147	R:R:P196	R:R:W202	4.05	No	No	0	4	1
148	R:R:E197	R:R:W202	20.72	No	No	0	3	1
149	R:R:A199	R:R:R203	9.68	No	Yes	0	4	4
150	R:R:R203	R:R:V281	3.92	Yes	Yes	0	4	5
151	R:R:A204	R:R:V281	5.09	No	Yes	0	2	5
152	R:R:I207	R:R:N277	14.16	No	No	0	5	6
153	R:R:I207	R:R:V281	4.61	No	Yes	0	5	5
154	R:R:L213	R:R:Y209	5.86	No	No	0	4	3
155	R:R:A211	R:R:Y274	4	No	Yes	0	6	8
156	R:R:G214	R:R:P218	4.06	No	Yes	0	5	8
157	R:R:F215	R:R:F216	5.36	No	No	0	8	4
158	R:R:F215	R:R:L219	7.31	No	Yes	0	8	5
159	R:R:F215	R:R:M271	9.95	No	No	0	8	5
160	R:R:G217	R:R:P218	4.06	No	Yes	0	5	8
161	R:R:F266	R:R:L219	8.53	No	Yes	0	9	5
162	R:R:L219	R:R:V267	4.47	Yes	No	0	5	6
163	R:R:C223	R:R:V263	6.83	No	No	0	4	7
164	R:R:V259	R:R:Y226	11.36	No	Yes	0	7	8
165	R:R:Y226	R:R:Y262	13.9	Yes	Yes	1	8	8
166	R:R:R234	R:R:V230	7.85	No	No	0	5	6
167	R:R:R234	R:R:R238	10.66	No	No	0	5	6
168	R:R:R238	R:R:R247	9.6	No	No	0	6	2
169	R:R:E252	R:R:R238	4.65	No	No	0	6	6
170	R:R:P243	R:R:W241	8.11	No	No	0	4	3
171	R:R:S244	R:R:W241	6.18	No	No	0	2	3
172	R:R:A242	R:R:R247	4.15	No	No	0	4	2
173	R:R:Q246	R:R:S244	11.55	No	No	0	1	2
174	R:R:C245	R:R:R250	4.18	No	No	0	2	4
175	R:R:R247	R:R:R248	6.4	No	No	0	2	4
176	R:R:M258	R:R:Y262	7.18	No	Yes	0	8	8
177	R:R:L316	R:R:M258	7.07	No	No	0	7	8
178	R:R:L312	R:R:Y262	9.38	No	Yes	0	8	8
179	R:R:A308	R:R:L265	4.73	No	No	0	6	7
180	R:R:L265	R:R:L312	5.54	No	No	0	7	8
181	R:R:F266	R:R:W270	21.05	No	Yes	1	9	8
182	R:R:F266	R:R:N305	4.83	No	Yes	1	9	9
183	R:R:C269	R:R:N305	7.87	No	Yes	0	8	9
184	R:R:W270	R:R:Y274	12.54	Yes	Yes	1	8	8
185	R:R:P302	R:R:W270	6.76	No	Yes	0	7	8
186	R:R:N305	R:R:W270	14.69	Yes	Yes	1	9	8
187	R:R:F273	R:R:Y274	11.35	Yes	Yes	1	6	8
188	R:R:F273	R:R:P302	8.67	Yes	No	0	6	7
189	R:R:L276	R:R:L294	5.54	Yes	No	0	4	5
190	R:R:L276	R:R:Y295	11.72	Yes	No	0	4	4
191	R:R:L276	R:R:V298	13.41	Yes	No	0	4	6
192	R:R:F291	R:R:L285	14.61	Yes	Yes	0	4	1
193	R:R:L285	R:R:Y295	5.86	Yes	No	0	1	4
194	R:R:E288	R:R:F291	15.16	No	Yes	0	1	4
195	R:R:F291	R:R:L294	3.65	Yes	No	0	4	5
196	R:R:F292	R:R:F296	16.08	No	Yes	0	3	4
197	R:R:F296	R:R:G293	4.52	Yes	No	0	4	3
198	R:R:N305	R:R:N309	9.54	Yes	Yes	1	9	9
199	R:R:F315	R:R:I311	5.02	Yes	No	0	6	6
200	R:R:F315	R:R:F324	7.5	Yes	No	4	6	5
201	R:R:F320	R:R:S317	7.93	Yes	No	0	8	8
202	R:R:F320	R:R:R319	6.41	Yes	No	5	8	6
203	R:R:P218	R:R:T135	3.5	Yes	No	0	8	7
204	R:R:P158	R:R:T156	3.5	No	No	0	4	7
205	R:R:Q246	R:R:R250	3.5	No	No	0	1	4
206	R:R:E252	R:R:R253	3.49	No	No	0	6	4
207	R:R:C307	R:R:V57	3.42	Yes	No	0	7	5
208	R:R:I47	R:R:P48	3.39	No	No	0	6	5
209	R:R:H72	R:R:R326	3.39	No	No	0	5	5
210	R:R:A160	R:R:V78	3.39	No	Yes	0	7	6
211	R:R:A121	R:R:V179	3.39	No	No	0	5	5
212	R:R:I131	R:R:P218	3.39	No	Yes	0	8	8
213	R:R:A89	R:R:T129	3.36	No	No	0	8	7
214	R:R:L106	R:R:P110	3.28	No	No	0	4	2
215	R:R:L301	R:R:P272	3.28	No	No	0	7	9
216	R:R:A87	R:R:I66	3.25	No	Yes	0	8	7
217	R:R:A172	R:R:I125	3.25	No	No	0	3	5
218	R:R:S77	R:R:T79	3.2	No	No	0	8	7
219	R:R:T135	R:R:V221	3.17	No	No	0	7	6
220	R:R:C223	R:R:L219	3.17	No	Yes	0	4	5
221	R:R:C269	R:R:L268	3.17	No	No	0	8	6
222	R:R:A101	R:R:L97	3.15	No	Yes	0	6	6
223	R:R:E197	R:R:P198	3.14	No	No	0	3	2
224	R:R:R254	R:R:Y318	3.09	No	No	0	7	4
225	R:R:M188	R:R:S189	3.07	No	No	0	1	4
226	R:R:K232	R:R:V145	3.04	No	No	0	5	8
227	R:R:K232	R:R:V146	3.04	No	No	0	5	6
228	R:R:M271	R:R:V275	3.04	No	No	0	5	7
229	R:R:F99	R:R:G96	3.01	No	No	0	5	6
230	R:R:G183	R:R:R186	3	No	No	0	4	3
231	R:R:G323	R:R:R326	3	No	No	0	4	5
232	R:R:L60	R:R:V57	2.98	No	No	0	5	5
233	R:R:L176	R:R:V173	2.98	Yes	No	0	4	3
234	R:R:I208	R:R:I278	2.94	No	No	0	4	5
235	R:R:F206	R:R:P177	2.89	No	No	0	5	7
236	R:R:Q246	R:R:S251	2.89	No	No	0	1	4
237	R:R:F291	R:R:P286	2.89	Yes	No	0	4	2
238	R:R:P185	R:R:R186	2.88	No	No	0	3	3
239	R:R:I66	R:R:L70	2.85	Yes	No	0	7	4
240	R:R:I66	R:R:L88	2.85	Yes	No	0	7	6
241	R:R:I125	R:R:N126	2.83	No	Yes	0	5	8
242	R:R:E252	R:R:T256	2.82	No	No	0	6	6
243	R:R:C245	R:R:R248	2.79	No	No	0	2	4
244	R:R:P177	R:R:Y209	2.78	No	No	0	7	3
245	R:R:A170	R:R:F132	2.77	No	Yes	0	4	5
246	R:R:A144	R:R:R155	2.77	No	Yes	0	8	7
247	R:R:L224	R:R:L228	2.77	No	No	0	5	4
248	R:R:L227	R:R:L228	2.77	No	No	0	3	4
249	R:R:L285	R:R:N280	2.75	Yes	No	0	1	4
250	R:R:R161	R:R:S75	2.64	No	No	0	3	6
251	R:R:R117	R:R:S113	2.64	No	No	0	6	2
252	R:R:F315	R:R:V65	2.62	Yes	No	0	6	9
253	R:R:R257	R:R:V260	2.62	No	No	0	6	5
254	R:R:L70	R:R:R71	2.43	No	No	0	4	5
255	R:R:F93	R:R:N126	2.42	No	Yes	0	7	8
256	R:R:I222	R:R:Y226	2.42	No	Yes	0	8	8
257	R:R:L143	R:R:Y142	2.34	No	Yes	0	5	8
258	R:R:R153	R:R:W154	2	No	No	0	4	2
259	R:R:A204	R:R:G205	1.95	No	No	0	2	4
260	R:R:A236	R:R:G237	1.95	No	No	0	6	4
261	R:R:C283	R:R:P284	1.88	No	No	0	3	1
262	R:R:A105	R:R:P48	1.87	No	No	0	4	5
263	R:R:A157	R:R:P158	1.87	No	No	0	1	4
264	R:R:G44	R:R:S43	1.86	No	No	0	4	3
265	R:R:G314	R:R:V65	1.84	No	No	0	7	9
266	R:R:P289	R:R:S43	1.78	No	No	0	3	3
267	R:R:P310	R:R:V65	1.77	No	No	0	9	9
268	R:R:C307	R:R:V54	1.71	Yes	No	0	7	7
269	R:R:C225	R:R:V139	1.71	No	No	0	7	6
270	R:R:C283	R:R:V282	1.71	No	No	0	3	3
271	R:R:M271	R:R:P272	1.68	No	No	0	5	9
272	R:R:L176	R:R:P177	1.64	Yes	No	0	4	7
273	R:R:G323	R:R:Q322	1.64	No	No	0	4	4
274	R:R:N280	R:R:P284	1.63	No	No	0	4	1
275	R:R:V53	R:R:V54	1.6	No	No	0	5	7
276	R:R:V53	R:R:V56	1.6	No	No	0	5	5
277	R:R:V56	R:R:V57	1.6	No	No	0	5	5
278	R:R:V159	R:R:V163	1.6	No	No	0	4	6
279	R:R:V179	R:R:V180	1.6	No	No	8	5	4
280	R:R:V230	R:R:V259	1.6	No	No	0	6	7
281	R:R:V255	R:R:V259	1.6	No	No	0	8	7
282	R:R:G187	R:R:H192	1.59	No	No	0	4	4
283	R:R:A101	R:R:L52	1.58	No	No	0	6	4
284	R:R:A290	R:R:L294	1.58	No	No	0	1	5
285	R:R:I278	R:R:V281	1.54	No	Yes	0	5	5
286	R:R:I278	R:R:V282	1.54	No	No	0	5	3
287	R:R:L114	R:R:S113	1.5	No	No	0	1	2
288	R:R:L46	R:R:V42	1.49	No	No	0	4	4
289	R:R:L49	R:R:V50	1.49	No	No	0	4	5
290	R:R:L118	R:R:V122	1.49	No	No	0	5	5
291	R:R:L176	R:R:V179	1.49	Yes	No	8	4	5
292	R:R:L176	R:R:V180	1.49	Yes	No	8	4	4
293	R:R:L276	R:R:V279	1.49	Yes	No	0	4	4
294	R:R:L285	R:R:V279	1.49	Yes	No	0	1	4
295	R:R:L328	R:R:V327	1.49	No	No	0	5	5
296	R:R:E91	R:R:S63	1.44	No	No	0	7	4
297	R:R:G112	R:R:W109	1.41	No	Yes	0	7	8
298	R:R:R234	R:R:V233	1.31	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	13.0233	6	1	0
2	L:L:?2	9.38571	7	1	0
3	L:L:K3	11.275	4	1	0
4	L:L:?4	8.56444	9	1	0
5	L:L:?6	16.69	4	1	0
6	R:R:Y51	5.88	4	2	7
7	R:R:I66	3.945	4	0	7
8	R:R:V78	7.06	4	1	6
9	R:R:N80	8.58	4	5	8
10	R:R:Y82	8.098	5	1	7
11	R:R:L86	6.3825	4	1	9
12	R:R:D90	7.022	5	1	9
13	R:R:M94	5.5075	4	3	6
14	R:R:L97	6.226	5	0	6
15	R:R:W109	6.44	7	1	8
16	R:R:N126	5.535	4	0	8
17	R:R:Q127	6.73333	6	1	7
18	R:R:F132	5.472	5	6	5
19	R:R:M137	5.6475	4	1	8
20	R:R:R141	7.5175	4	1	9
21	R:R:Y142	6.09	6	7	8
22	R:R:R155	6.09	4	1	7
23	R:R:L176	1.9	4	8	4
24	R:R:M193	7.585	4	0	4
25	R:R:W195	7.95	4	1	6
26	R:R:R203	8.3475	4	1	4
27	R:R:P218	3.7525	4	0	8
28	R:R:L219	5.87	4	0	5
29	R:R:Y226	9.235	4	1	8
30	R:R:Y262	8.9	4	1	8
31	R:R:W270	12.565	6	1	8
32	R:R:F273	8.4875	4	1	6
33	R:R:Y274	8.945	4	1	8
34	R:R:L276	8.04	4	0	4
35	R:R:V281	3.79	4	0	5
36	R:R:L285	6.1775	4	0	1
37	R:R:F291	9.0775	4	0	4
38	R:R:F296	12.27	5	2	4
39	R:R:N305	9.2325	4	1	9
40	R:R:C307	3.4775	4	3	7
41	R:R:N309	7.515	4	1	9
42	R:R:F315	5.0025	4	4	6
43	R:R:F320	8.08	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W195	14.9901	11.97	Yes	Yes	1	0	6
2	R:R:M193	R:R:W195	11.0017	5.82	Yes	Yes	0	4	6
3	L:L:?4	R:R:W109	18.9196	4.67	Yes	Yes	1	0	8
4	L:L:?1	L:L:?6	24.5151	25.64	Yes	Yes	1	0	0
5	L:L:?6	L:L:F5	48.7946	25.68	Yes	No	0	0	0
6	L:L:F5	R:R:F292	26.341	18.22	No	No	0	0	3
7	L:L:F5	R:R:Y295	22.7649	17.54	No	No	0	0	4
8	R:R:F292	R:R:F296	24.6371	16.08	No	Yes	0	3	4
9	R:R:F296	R:R:I47	14.3338	23.86	Yes	No	0	4	6
10	R:R:C55	R:R:L97	12.0283	9.52	No	Yes	0	6	6
11	R:R:C55	R:R:M94	10.9765	4.86	No	Yes	0	6	6
12	L:L:?1	L:L:?2	41.3185	13.32	Yes	Yes	1	0	0
13	L:L:?2	R:R:Q127	92.4692	6.34	Yes	Yes	1	0	7
14	R:R:Q127	R:R:W270	97.8922	10.95	Yes	Yes	1	7	8
15	R:R:N305	R:R:W270	95.2669	14.69	Yes	Yes	1	9	8
16	R:R:N305	R:R:N309	100	9.54	Yes	Yes	1	9	9
17	R:R:D90	R:R:N309	31.4317	4.04	Yes	Yes	1	9	9
18	R:R:D90	R:R:N62	37.4648	6.73	Yes	No	0	9	9
19	R:R:N62	R:R:P310	14.6872	6.52	No	No	0	9	9
20	R:R:E91	R:R:N62	22.3611	10.52	No	No	0	7	9
21	R:R:P310	R:R:V65	11.4813	1.77	No	No	0	9	9
22	R:R:E91	R:R:I66	19.2309	6.83	No	Yes	0	7	7
23	R:R:I66	R:R:L70	14.4853	2.85	Yes	No	0	7	4
24	R:R:L70	R:R:R71	12.8865	2.43	No	No	0	4	5
25	R:R:R71	R:R:Y67	11.2794	16.46	No	No	0	5	4
26	R:R:L134	R:R:N309	74.0671	12.36	No	Yes	1	8	9
27	R:R:L134	R:R:Y313	86.6423	8.21	No	No	1	8	9
28	R:R:M137	R:R:Y313	36.1858	5.99	Yes	No	1	8	9
29	R:R:I83	R:R:M137	16.7193	4.37	No	Yes	0	8	8
30	R:R:F320	R:R:I83	15.3519	10.05	Yes	No	0	8	8
31	R:R:M137	R:R:Y82	26.0634	4.79	Yes	Yes	1	8	7
32	R:R:V78	R:R:Y82	11.1658	12.62	Yes	Yes	1	6	7
33	R:R:L86	R:R:N309	11.7758	4.12	Yes	Yes	1	9	9
34	R:R:C133	R:R:L86	16.7319	6.35	No	Yes	0	7	9
35	R:R:C133	R:R:N85	15.495	6.3	No	No	0	7	9
36	R:R:N85	R:R:W168	12.9959	7.91	No	No	0	9	9
37	R:R:F93	R:R:Q127	18.7681	7.03	No	Yes	0	7	7
38	R:R:F93	R:R:Y303	10.5516	14.44	No	No	0	7	6
39	R:R:L97	R:R:Y303	10.1308	9.38	Yes	No	0	6	6
40	R:R:T129	R:R:W168	11.7338	15.77	No	No	0	7	9
41	R:R:R141	R:R:Y313	49.6108	8.23	Yes	No	1	9	9
42	R:R:R141	R:R:Y226	46.8551	9.26	Yes	Yes	1	9	8
43	R:R:I222	R:R:Y226	23.4381	2.42	No	Yes	0	8	8
44	R:R:I222	R:R:S138	22.1213	9.29	No	No	0	8	9
45	R:R:C225	R:R:S138	20.796	6.89	No	No	0	7	9
46	R:R:C225	R:R:Y142	18.1202	5.38	No	Yes	0	7	8
47	L:L:?2	R:R:M193	15.415	6.73	Yes	Yes	0	0	4
48	R:R:F206	R:R:W195	24.1828	6.01	No	Yes	0	5	6
49	R:R:F206	R:R:P177	22.6514	2.89	No	No	0	5	7
50	R:R:L176	R:R:P177	17.5817	1.64	Yes	No	0	4	7
51	R:R:L176	R:R:V180	10.5978	1.49	Yes	No	8	4	4
52	L:L:?1	R:R:R203	11.5192	11.79	Yes	Yes	1	0	4
53	R:R:R203	R:R:V281	10.4969	3.92	Yes	Yes	0	4	5
54	R:R:F266	R:R:L219	12.9959	8.53	No	Yes	0	9	5
55	R:R:V259	R:R:Y226	25.8782	11.36	No	Yes	0	7	8
56	R:R:V230	R:R:V259	23.3329	1.6	No	No	0	6	7
57	R:R:R234	R:R:V230	22.0203	7.85	No	No	0	5	6
58	R:R:R234	R:R:R238	19.3614	10.66	No	No	0	5	6
59	R:R:R238	R:R:R247	14.0309	9.6	No	No	0	6	2
60	R:R:R247	R:R:R248	11.372	6.4	No	No	0	2	4
61	R:R:L285	R:R:Y295	12.3438	5.86	Yes	No	0	1	4
62	L:L:?2	L:L:?4	40.536	4.51	Yes	Yes	1	0	0
63	L:L:?4	L:L:?6	27.3213	9.37	Yes	Yes	1	0	0
64	R:R:D90	R:R:L86	10.3959	8.14	Yes	Yes	1	9	9
65	R:R:L134	R:R:L86	13.3998	6.92	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H192	6.24	1	Yes	No	0	4	0	1
L:L:?1	R:R:W195	11.97	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R203	11.79	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:Q127	6.34	1	Yes	Yes	0	7	0	1
L:L:?2	R:R:M193	6.73	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:T210	4.68	1	Yes	No	0	5	0	1
L:L:?2	R:R:F273	7.73	1	Yes	Yes	0	6	0	1
L:L:K3	R:R:D123	12.44	1	Yes	No	0	6	0	1
L:L:K3	R:R:Q127	4.07	1	Yes	Yes	0	7	0	1
L:L:K3	R:R:F273	6.2	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:L100	14.76	1	Yes	No	0	7	0	1
L:L:?4	R:R:Q103	9.83	1	Yes	No	0	5	0	1
L:L:?4	R:R:W109	4.67	1	Yes	Yes	0	8	0	1
L:L:?4	R:R:V119	13.44	1	Yes	No	0	5	0	1
L:L:?4	R:R:M120	4.64	1	Yes	No	0	4	0	1
L:L:?4	R:R:D123	6.68	1	Yes	No	0	6	0	1
L:L:F5	R:R:F292	18.22	0	No	No	0	3	0	1
L:L:F5	R:R:Y295	17.54	0	No	No	0	4	0	1
L:L:?6	R:R:E287	6.07	1	Yes	No	0	1	0	1
R:R:F93	R:R:Q127	7.03	0	No	Yes	7	7	2	1
R:R:L100	R:R:L97	4.15	0	No	Yes	7	6	1	2
R:R:F99	R:R:W109	5.01	0	No	Yes	5	8	2	1
R:R:F99	R:R:V119	5.24	0	No	No	5	5	2	1
R:R:Q103	R:R:W109	4.38	1	No	Yes	5	8	1	1
R:R:F111	R:R:W109	10.02	0	No	Yes	6	8	2	1
R:R:C116	R:R:W109	7.84	1	No	Yes	9	8	2	1
R:R:C191	R:R:W109	11.75	1	No	Yes	9	8	2	1
R:R:C116	R:R:C191	7.28	1	No	No	9	9	2	2
R:R:M120	R:R:S182	6.13	0	No	No	4	5	1	2
R:R:M120	R:R:M193	8.66	0	No	Yes	4	4	1	1
R:R:D123	R:R:G124	5.03	0	No	No	6	4	1	2
R:R:I131	R:R:Q127	4.12	1	No	Yes	8	7	2	1
R:R:Q127	R:R:W270	10.95	1	Yes	Yes	7	8	1	2
R:R:Q127	R:R:Y274	7.89	1	Yes	Yes	7	8	1	2
R:R:I131	R:R:W270	9.4	1	No	Yes	8	8	2	2
R:R:M193	R:R:V178	9.13	0	Yes	No	4	4	1	2
R:R:H192	R:R:T190	15.06	0	No	No	4	4	1	2
R:R:M193	R:R:W195	5.82	0	Yes	Yes	4	6	1	1
R:R:R203	R:R:W195	8	1	Yes	Yes	4	6	1	1
R:R:F206	R:R:W195	6.01	0	No	Yes	5	6	2	1
R:R:A199	R:R:R203	9.68	0	No	Yes	4	4	2	1
R:R:R203	R:R:V281	3.92	1	Yes	Yes	4	5	1	2
R:R:W270	R:R:Y274	12.54	1	Yes	Yes	8	8	2	2
R:R:P302	R:R:W270	6.76	0	No	Yes	7	8	2	2
R:R:F273	R:R:Y274	11.35	1	Yes	Yes	6	8	1	2
R:R:F273	R:R:P302	8.67	1	Yes	No	6	7	1	2
R:R:L276	R:R:Y295	11.72	0	Yes	No	4	4	2	1
R:R:L285	R:R:Y295	5.86	0	Yes	No	1	4	2	1
R:R:F292	R:R:F296	16.08	0	No	Yes	3	4	1	2
R:R:G187	R:R:H192	1.59	0	No	No	4	4	2	1
R:R:G112	R:R:W109	1.41	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XIR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.56
Number of Linked Nodes	267
Number of Links	298
Number of Hubs	43
Number of Links mediated by Hubs	160
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	45836
Length Of Smallest Path	3
Average Path Length	13.3595
Length of Longest Path	32
Minimum Path Strength	1.49
Average Path Strength	8.54124
Maximum Path Strength	25.66
Minimum Path Correlation	0.7
Average Path Correlation	0.928295
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	51.7326
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.5491
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • response to endogenous stimulus • cell death • hormone-mediated signaling pathway • apoptotic signaling pathway • cellular response to endogenous stimulus • hormone-mediated apoptotic signaling pathway • response to hormone • apoptotic process • programmed cell death • cellular response to hormone stimulus • cell-cell signaling • cerebellum development • metencephalon development • hindbrain development • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to corticosteroid • response to steroid hormone • cellular response to steroid hormone stimulus • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • non-motile cilium • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • non-motile cilium • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • neuron projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	004
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	004
Name	(2S)-amino(phenyl)ethanoic acid
Synonyms	L-Phenylglycine
Identifier
Formula	C8 H9 N O2
Molecular Weight	151.163
SMILES
PubChem	6931074
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	TY5
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	TY5
Name	O-benzyl-L-tyrosine
Synonyms
Identifier
Formula	C16 H17 N O3
Molecular Weight	271.311
SMILES
PubChem	725701
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	1
Total Bonds	38
Total Aromatic Bonds	12


Code	A1D
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32745
Sequence	>8XIR_nogp_Chain_R L A V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H T A S P S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S Y W P F G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H P T R S A R W R T A P V A R T V S A A V W V A S A V V V L P V V V F S G V P R G M S T C H M Q W P E P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V W A P S C Q R R R R S E R R V T R M V V A V A L F V L C W M P F Y V L N I V N V V C P L P E E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F K Q G F R R V L Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XIR	A	Peptide	Somatostatin	SST3	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.52	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIR (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	Pasireotide	-		2.52	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIQ	A	Peptide	Somatostatin	SST3	Homo sapiens	L796778	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.71	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIQ (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	L796778	-		2.71	2024-07-03	doi.org/10.1073/pnas.2400298121

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Download 8XIR_nogp.zip

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