psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	28.91	Yes	Yes	1	0	0
2	L:L:?1	L:L:?4	8.1	Yes	Yes	1	0	0
3	L:L:?1	R:R:F99	4.64	Yes	Yes	1	0	5
4	L:L:?1	R:R:L100	18.47	Yes	No	0	0	7
5	L:L:?1	R:R:Q103	8.88	Yes	No	1	0	5
6	L:L:?1	R:R:V119	8.52	Yes	No	1	0	5
7	L:L:?1	R:R:M120	14.82	Yes	No	0	0	4
8	L:L:?1	R:R:D123	6.47	Yes	Yes	1	0	6
9	L:L:?2	L:L:?3	26.76	Yes	Yes	1	0	0
10	L:L:?2	L:L:?4	25.55	Yes	Yes	1	0	0
11	L:L:?2	R:R:D123	5.25	Yes	Yes	1	0	6
12	L:L:?2	R:R:G124	6.61	Yes	No	0	0	4
13	L:L:?2	R:R:F128	4.71	Yes	Yes	0	0	6
14	L:L:?2	R:R:V179	3.84	Yes	No	0	0	5
15	L:L:?2	R:R:M193	5.47	Yes	Yes	1	0	4
16	L:L:?2	R:R:F206	17.27	Yes	Yes	1	0	5
17	L:L:?3	L:L:?4	19.92	Yes	Yes	1	0	0
18	L:L:?3	R:R:M193	3.98	Yes	Yes	1	0	4
19	L:L:?3	R:R:W195	3.2	Yes	Yes	1	0	6
20	L:L:?3	R:R:F206	3.43	Yes	Yes	1	0	5
21	L:L:?3	R:R:F273	4.57	Yes	Yes	1	0	6
22	L:L:?3	R:R:N277	3.86	Yes	No	1	0	6
23	L:L:?4	R:R:D123	6.94	Yes	Yes	1	0	6
24	L:L:?4	R:R:Q127	4.09	Yes	No	0	0	7
25	L:L:?4	R:R:F273	3.74	Yes	Yes	1	0	6
26	L:L:?4	R:R:Y295	3.6	Yes	No	0	0	4
27	L:L:?4	R:R:V299	13.72	Yes	No	0	0	5
28	L:L:?4	R:R:Y303	8.4	Yes	Yes	1	0	6
29	R:R:I47	R:R:P48	5.08	Yes	No	0	6	5
30	R:R:I47	R:R:Y51	6.04	Yes	Yes	4	6	7
31	R:R:F296	R:R:I47	7.54	Yes	Yes	4	4	6
32	R:R:A105	R:R:P48	3.74	No	No	0	4	5
33	R:R:L97	R:R:Y51	5.86	No	Yes	0	6	7
34	R:R:F296	R:R:Y51	3.09	Yes	Yes	4	4	7
35	R:R:A300	R:R:Y51	4	No	Yes	0	4	7
36	R:R:L52	R:R:P98	3.28	No	No	0	4	8
37	R:R:C55	R:R:L59	4.76	No	No	0	6	7
38	R:R:C55	R:R:M94	4.86	No	No	0	6	6
39	R:R:C55	R:R:L97	3.17	No	No	0	6	6
40	R:R:C307	R:R:G58	3.92	No	No	0	7	8
41	R:R:E91	R:R:L59	6.63	No	No	0	7	7
42	R:R:G61	R:R:L60	3.42	No	No	0	7	5
43	R:R:D90	R:R:N62	6.73	Yes	No	2	9	9
44	R:R:E91	R:R:N62	7.89	No	No	0	7	9
45	R:R:N62	R:R:P310	8.15	No	No	2	9	9
46	R:R:F315	R:R:L64	7.31	No	No	0	6	5
47	R:R:V65	R:R:V68	3.21	No	No	0	9	7
48	R:R:R71	R:R:Y67	12.35	No	No	5	5	4
49	R:R:H72	R:R:Y67	19.6	No	No	5	5	4
50	R:R:F320	R:R:V68	6.55	Yes	No	0	8	7
51	R:R:F324	R:R:V68	6.55	No	No	0	5	7
52	R:R:L84	R:R:V69	5.96	No	No	0	5	7
53	R:R:H72	R:R:R71	3.39	No	No	5	5	5
54	R:R:N80	R:R:T73	4.39	No	No	0	8	6
55	R:R:P76	R:R:S75	3.56	No	No	0	6	6
56	R:R:R319	R:R:S77	5.27	No	No	0	6	8
57	R:R:V78	R:R:Y82	7.57	Yes	Yes	3	6	7
58	R:R:D140	R:R:V78	4.38	No	Yes	3	8	6
59	R:R:R155	R:R:V78	6.54	Yes	Yes	3	7	6
60	R:R:A160	R:R:V78	5.09	No	Yes	3	7	6
61	R:R:I83	R:R:T79	3.04	No	No	0	8	7
62	R:R:R155	R:R:T79	3.88	Yes	No	0	7	7
63	R:R:R319	R:R:T79	6.47	No	No	0	6	7
64	R:R:N80	R:R:R319	6.03	No	No	0	8	6
65	R:R:A160	R:R:V81	3.39	No	No	0	7	6
66	R:R:V136	R:R:Y82	6.31	No	Yes	3	6	7
67	R:R:M137	R:R:Y82	3.59	No	Yes	0	8	7
68	R:R:D140	R:R:Y82	8.05	No	Yes	3	8	7
69	R:R:A160	R:R:Y82	5.34	No	Yes	3	7	7
70	R:R:V163	R:R:Y82	3.79	No	Yes	3	6	7
71	R:R:F320	R:R:I83	5.02	Yes	No	0	8	8
72	R:R:C133	R:R:N85	6.3	No	No	0	7	9
73	R:R:N85	R:R:S164	7.45	No	No	0	9	8
74	R:R:N85	R:R:W168	6.78	No	No	0	9	9
75	R:R:D90	R:R:L86	8.14	Yes	No	2	9	9
76	R:R:L134	R:R:L86	5.54	No	No	2	8	9
77	R:R:L86	R:R:Y313	3.52	No	Yes	2	9	9
78	R:R:A89	R:R:T129	3.36	No	No	0	8	7
79	R:R:D90	R:R:S306	4.42	Yes	No	0	9	8
80	R:R:D90	R:R:N309	4.04	Yes	Yes	2	9	9
81	R:R:D90	R:R:P310	3.22	Yes	No	2	9	9
82	R:R:L92	R:R:N126	8.24	No	No	0	6	8
83	R:R:F93	R:R:N126	3.62	No	No	0	7	8
84	R:R:F93	R:R:Y303	21.66	No	Yes	0	7	6
85	R:R:F93	R:R:S306	7.93	No	No	0	7	8
86	R:R:M94	R:R:Y303	5.99	No	Yes	0	6	6
87	R:R:C307	R:R:M94	4.86	No	No	0	7	6
88	R:R:L97	R:R:Y303	9.38	No	Yes	0	6	6
89	R:R:F99	R:R:W109	5.01	Yes	Yes	1	5	8
90	R:R:F99	R:R:V119	10.49	Yes	No	1	5	5
91	R:R:Q103	R:R:W109	7.67	No	Yes	1	5	8
92	R:R:C191	R:R:Q103	9.16	No	No	1	9	5
93	R:R:F296	R:R:N104	12.08	Yes	No	0	4	5
94	R:R:P110	R:R:Y108	8.34	No	No	0	2	4
95	R:R:F111	R:R:W109	19.04	No	Yes	0	6	8
96	R:R:C116	R:R:W109	3.92	No	Yes	1	9	8
97	R:R:C191	R:R:W109	11.75	No	Yes	1	9	8
98	R:R:F111	R:R:M115	4.98	No	No	0	6	5
99	R:R:S113	R:R:V184	6.46	No	Yes	6	2	4
100	R:R:R186	R:R:S113	9.22	No	No	6	3	2
101	R:R:L114	R:R:L118	6.92	No	No	0	1	5
102	R:R:M115	R:R:V119	3.04	No	No	0	5	5
103	R:R:C116	R:R:M120	4.86	No	No	0	9	4
104	R:R:C116	R:R:C191	5.46	No	No	1	9	9
105	R:R:M120	R:R:R117	3.72	No	No	0	4	6
106	R:R:R117	R:R:V184	6.54	No	Yes	0	6	4
107	R:R:N126	R:R:V122	4.43	No	No	0	8	5
108	R:R:D123	R:R:Y303	4.6	Yes	Yes	1	6	6
109	R:R:G124	R:R:V175	3.68	No	No	0	4	7
110	R:R:I125	R:R:S171	4.64	No	No	0	5	8
111	R:R:I125	R:R:V175	4.61	No	No	0	5	7
112	R:R:F128	R:R:Q127	3.51	Yes	No	0	6	7
113	R:R:F128	R:R:F132	3.22	Yes	No	0	6	5
114	R:R:F128	R:R:S171	3.96	Yes	No	0	6	8
115	R:R:F128	R:R:V174	7.87	Yes	No	0	6	5
116	R:R:F128	R:R:V175	5.24	Yes	No	0	6	7
117	R:R:T129	R:R:W168	16.98	No	No	0	7	9
118	R:R:S171	R:R:T129	4.8	No	No	0	8	7
119	R:R:I131	R:R:P218	3.39	No	No	0	8	8
120	R:R:I131	R:R:W270	8.22	No	Yes	0	8	8
121	R:R:F132	R:R:V167	6.55	No	No	0	5	6
122	R:R:L134	R:R:N309	8.24	No	Yes	2	8	9
123	R:R:L134	R:R:Y313	4.69	No	Yes	2	8	9
124	R:R:P218	R:R:T135	3.5	No	No	0	8	7
125	R:R:T135	R:R:V221	3.17	No	No	0	7	6
126	R:R:V136	R:R:V163	3.21	No	No	3	6	6
127	R:R:M137	R:R:R141	12.41	No	No	0	8	9
128	R:R:I222	R:R:S138	6.19	No	No	0	8	9
129	R:R:C225	R:R:S138	3.44	No	No	0	7	9
130	R:R:D140	R:R:R155	13.1	No	Yes	3	8	7
131	R:R:R141	R:R:Y313	7.2	No	Yes	0	9	9
132	R:R:L143	R:R:Y142	4.69	Yes	Yes	0	5	8
133	R:R:V146	R:R:Y142	6.31	No	Yes	7	6	8
134	R:R:H147	R:R:Y142	3.27	No	Yes	7	6	8
135	R:R:C225	R:R:Y142	6.72	No	Yes	0	7	8
136	R:R:L228	R:R:Y142	8.21	No	Yes	0	4	8
137	R:R:I229	R:R:V145	7.68	No	No	0	8	8
138	R:R:H147	R:R:V146	11.07	No	No	7	6	6
139	R:R:H147	R:R:R150	18.05	No	No	0	6	4
140	R:R:R150	R:R:T149	3.88	No	No	0	4	5
141	R:R:P158	R:R:T156	3.5	No	No	0	4	7
142	R:R:T156	R:R:V159	3.17	No	No	0	7	4
143	R:R:F181	R:R:V180	3.93	No	No	0	4	4
144	R:R:M193	R:R:S182	4.6	Yes	No	1	4	5
145	R:R:S182	R:R:W195	3.71	No	Yes	1	5	6
146	R:R:P185	R:R:V184	3.53	No	Yes	0	3	4
147	R:R:R186	R:R:V184	9.15	No	Yes	6	3	4
148	R:R:H192	R:R:P185	3.05	No	No	0	4	3
149	R:R:P185	R:R:Q194	11.05	No	No	0	3	3
150	R:R:H192	R:R:T190	10.95	No	No	0	4	4
151	R:R:M193	R:R:W195	9.31	Yes	Yes	1	4	6
152	R:R:R203	R:R:W195	15.99	No	Yes	0	4	6
153	R:R:F206	R:R:W195	11.02	Yes	Yes	1	5	6
154	R:R:P196	R:R:W202	24.32	No	No	0	4	1
155	R:R:E197	R:R:P198	3.14	No	No	0	3	2
156	R:R:P198	R:R:W202	8.11	No	No	0	2	1
157	R:R:R203	R:R:V281	5.23	No	No	0	4	5
158	R:R:L213	R:R:Y209	8.21	No	No	0	4	3
159	R:R:T210	R:R:Y274	7.49	No	Yes	0	5	8
160	R:R:A211	R:R:Y274	5.34	No	Yes	0	6	8
161	R:R:F215	R:R:L219	4.87	No	Yes	0	8	5
162	R:R:F215	R:R:M271	7.46	No	No	0	8	5
163	R:R:G217	R:R:P218	4.06	No	No	0	5	8
164	R:R:C223	R:R:L219	3.17	No	Yes	0	4	5
165	R:R:F266	R:R:L219	9.74	No	Yes	0	9	5
166	R:R:L220	R:R:L224	5.54	No	No	0	4	5
167	R:R:I222	R:R:Y226	8.46	No	Yes	0	8	8
168	R:R:V259	R:R:Y226	13.88	No	Yes	0	7	8
169	R:R:V262	R:R:Y226	5.05	No	Yes	0	8	8
170	R:R:R234	R:R:V230	7.85	No	No	0	5	6
171	R:R:E252	R:R:V233	5.7	No	No	0	6	8
172	R:R:E252	R:R:R234	9.3	No	No	0	6	5
173	R:R:R238	R:R:S235	3.95	No	No	0	6	4
174	R:R:R239	R:R:S235	5.27	No	No	0	4	4
175	R:R:R238	R:R:R248	3.2	No	No	0	6	4
176	R:R:V240	R:R:W241	8.58	No	Yes	0	5	3
177	R:R:S244	R:R:W241	4.94	No	Yes	0	2	3
178	R:R:C245	R:R:W241	9.14	No	Yes	0	2	3
179	R:R:A242	R:R:P243	3.74	No	No	0	4	4
180	R:R:R250	R:R:R253	10.66	No	No	0	4	4
181	R:R:R253	R:R:R257	17.06	No	No	0	4	6
182	R:R:L316	R:R:M258	4.24	No	No	0	7	8
183	R:R:L265	R:R:L268	4.15	No	No	0	7	6
184	R:R:L265	R:R:L312	4.15	No	Yes	8	7	8
185	R:R:F266	R:R:W270	18.04	No	Yes	0	9	8
186	R:R:M271	R:R:V267	4.56	No	No	0	5	6
187	R:R:C269	R:R:L268	3.17	No	No	0	8	6
188	R:R:C269	R:R:N305	9.45	No	No	0	8	9
189	R:R:W270	R:R:Y274	3.86	Yes	Yes	0	8	8
190	R:R:N305	R:R:W270	6.78	No	Yes	0	9	8
191	R:R:M271	R:R:P272	3.35	No	No	0	5	9
192	R:R:F273	R:R:Y274	7.22	Yes	Yes	0	6	8
193	R:R:F273	R:R:N277	15.71	Yes	No	1	6	6
194	R:R:L276	R:R:Y295	7.03	No	No	0	4	4
195	R:R:L276	R:R:V298	5.96	No	No	0	4	6
196	R:R:L285	R:R:N280	8.24	No	No	0	1	4
197	R:R:C283	R:R:V282	5.12	No	No	0	3	3
198	R:R:L285	R:R:P286	3.28	No	No	0	1	2
199	R:R:E287	R:R:F292	5.83	No	No	0	1	3
200	R:R:E288	R:R:P289	7.86	No	No	0	1	3
201	R:R:E288	R:R:F291	5.83	No	No	0	1	4
202	R:R:F296	R:R:G293	4.52	Yes	No	0	4	3
203	R:R:N305	R:R:N309	9.54	No	Yes	0	9	9
204	R:R:N309	R:R:Y313	5.81	Yes	Yes	2	9	9
205	R:R:F315	R:R:F324	5.36	No	No	0	6	5
206	R:R:F320	R:R:S317	5.28	Yes	No	0	8	8
207	R:R:Q322	R:R:Y318	27.05	No	No	0	4	4
208	R:R:K321	R:R:Q322	4.07	No	No	0	8	4
209	R:R:F99	R:R:G96	3.01	Yes	No	0	5	6
210	R:R:F320	R:R:G314	3.01	Yes	No	0	8	7
211	R:R:L60	R:R:S63	3	No	No	0	5	4
212	R:R:L143	R:R:S151	3	Yes	No	0	5	5
213	R:R:R153	R:R:W154	3	No	No	0	4	2
214	R:R:G323	R:R:R326	3	No	No	0	4	5
215	R:R:L46	R:R:V50	2.98	No	No	0	4	5
216	R:R:L70	R:R:V69	2.98	No	No	0	4	7
217	R:R:L143	R:R:V139	2.98	Yes	No	0	5	6
218	R:R:L227	R:R:V231	2.98	No	No	0	3	3
219	R:R:L294	R:R:V298	2.98	No	No	0	5	6
220	R:R:D90	R:R:S130	2.94	Yes	No	0	9	9
221	R:R:I207	R:R:I278	2.94	No	Yes	0	5	5
222	R:R:F111	R:R:P110	2.89	No	No	0	6	2
223	R:R:F291	R:R:P286	2.89	No	No	0	4	2
224	R:R:P148	R:R:R150	2.88	No	No	0	8	4
225	R:R:I47	R:R:L46	2.85	Yes	No	0	6	4
226	R:R:I66	R:R:L70	2.85	No	No	0	7	4
227	R:R:I125	R:R:L176	2.85	No	No	0	5	4
228	R:R:I222	R:R:L219	2.85	No	Yes	0	8	5
229	R:R:G112	R:R:W109	2.81	No	Yes	0	7	8
230	R:R:W195	R:R:W202	2.81	Yes	No	0	6	1
231	R:R:C245	R:R:R248	2.79	No	No	0	2	4
232	R:R:H72	R:R:V327	2.77	No	No	0	5	5
233	R:R:A144	R:R:R155	2.77	No	Yes	0	8	7
234	R:R:E91	R:R:I66	2.73	No	No	0	7	7
235	R:R:P302	R:R:W270	2.7	No	Yes	0	7	8
236	L:L:?3	R:R:I207	2.68	Yes	No	0	0	5
237	R:R:F206	R:R:V178	2.62	Yes	No	0	5	4
238	R:R:R257	R:R:T256	2.59	No	No	0	6	6
239	R:R:S189	R:R:Y108	2.54	No	No	0	4	4
240	R:R:V174	R:R:Y209	2.52	No	No	0	5	3
241	R:R:V263	R:R:Y226	2.52	No	Yes	0	7	8
242	R:R:R247	R:R:R250	2.13	No	No	0	2	4
243	R:R:G96	R:R:P98	2.03	No	No	0	6	8
244	R:R:A236	R:R:G237	1.95	No	No	0	6	4
245	R:R:C283	R:R:P284	1.88	No	No	0	3	1
246	R:R:A101	R:R:P48	1.87	No	No	0	6	5
247	R:R:A157	R:R:P158	1.87	No	No	0	1	4
248	R:R:A201	R:R:P198	1.87	No	No	0	1	2
249	R:R:G58	R:R:V57	1.84	No	No	0	8	5
250	R:R:G237	R:R:V240	1.84	No	No	0	4	5
251	R:R:G214	R:R:I131	1.76	No	No	0	5	8
252	R:R:G61	R:R:L64	1.71	No	No	0	7	5
253	R:R:G96	R:R:L95	1.71	No	No	0	6	5
254	R:R:G217	R:R:L220	1.71	No	No	0	5	4
255	R:R:A87	R:R:V65	1.7	No	No	0	8	9
256	R:R:A121	R:R:V179	1.7	No	No	0	5	5
257	R:R:A204	R:R:V281	1.7	No	No	0	2	5
258	R:R:L176	R:R:P177	1.64	No	No	0	4	7
259	R:R:G183	R:R:Q194	1.64	No	No	0	4	3
260	R:R:E252	R:R:G237	1.64	No	No	0	6	4
261	R:R:L301	R:R:P272	1.64	No	No	0	7	9
262	R:R:L301	R:R:P302	1.64	No	No	0	7	7
263	R:R:S75	R:R:S77	1.63	No	No	0	6	8
264	R:R:S235	R:R:V231	1.62	No	No	0	4	3
265	R:R:V50	R:R:V54	1.6	No	No	0	5	7
266	R:R:V159	R:R:V163	1.6	No	No	0	4	6
267	R:R:V169	R:R:V173	1.6	No	No	0	4	3
268	R:R:V179	R:R:V180	1.6	No	No	0	5	4
269	R:R:V255	R:R:V259	1.6	No	No	0	8	7
270	R:R:V275	R:R:V279	1.6	No	No	0	7	4
271	R:R:T256	R:R:V260	1.59	No	No	0	6	5
272	R:R:A105	R:R:L106	1.58	No	No	0	4	4
273	R:R:A172	R:R:L176	1.58	No	No	0	3	4
274	R:R:A308	R:R:L265	1.58	No	No	8	6	7
275	R:R:A308	R:R:L312	1.58	No	Yes	8	6	8
276	R:R:I47	R:R:S43	1.55	Yes	No	0	6	3
277	R:R:I229	R:R:V146	1.54	No	No	0	8	6
278	R:R:I229	R:R:V233	1.54	No	No	0	8	8
279	R:R:I278	R:R:V279	1.54	Yes	No	0	5	4
280	R:R:I278	R:R:V282	1.54	Yes	No	0	5	3
281	R:R:F216	R:R:G217	1.51	No	No	0	4	5
282	R:R:A290	R:R:E288	1.51	No	No	0	1	1
283	R:R:F292	R:R:G293	1.51	No	No	0	3	3
284	R:R:G187	R:R:R186	1.5	No	No	0	4	3
285	R:R:L49	R:R:V45	1.49	No	No	0	4	6
286	R:R:I208	R:R:I278	1.47	No	Yes	0	4	5
287	R:R:I311	R:R:L312	1.43	No	Yes	0	6	8
288	R:R:A170	R:R:F132	1.39	No	No	0	4	5
289	R:R:A212	R:R:F216	1.39	No	No	0	4	4
290	R:R:L84	R:R:L88	1.38	No	No	0	5	6
291	R:R:A199	R:R:R203	1.38	No	No	0	4	4
292	R:R:L312	R:R:L316	1.38	Yes	No	0	8	7
293	R:R:P243	R:R:W241	1.35	No	Yes	0	4	3
294	R:R:R161	R:R:V81	1.31	No	No	0	3	6
295	R:R:S107	R:R:Y108	1.27	No	No	0	3	4
296	R:R:K232	R:R:R239	1.24	No	No	0	5	4
297	R:R:L143	R:R:W154	1.14	Yes	No	0	5	2
298	R:R:R249	R:R:R257	1.07	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.3513	8	1	0
2	L:L:?2	13.8189	9	1	0
3	L:L:?3	8.55	8	1	0
4	L:L:?4	10.4511	9	1	0
5	R:R:I47	4.612	5	4	6
6	R:R:Y51	4.7475	4	4	7
7	R:R:V78	5.895	4	3	6
8	R:R:Y82	5.775	6	3	7
9	R:R:D90	4.915	6	2	9
10	R:R:F99	5.7875	4	1	5
11	R:R:W109	8.36667	6	1	8
12	R:R:D123	5.815	4	1	6
13	R:R:F128	4.75167	6	0	6
14	R:R:Y142	5.84	5	7	8
15	R:R:L143	2.9525	4	0	5
16	R:R:R155	6.5725	4	3	7
17	R:R:V184	6.42	4	6	4
18	R:R:M193	5.84	4	1	4
19	R:R:W195	7.67333	6	1	6
20	R:R:F206	8.585	4	1	5
21	R:R:L219	5.1575	4	0	5
22	R:R:Y226	7.4775	4	0	8
23	R:R:W241	6.0025	4	0	3
24	R:R:W270	7.92	5	0	8
25	R:R:F273	7.81	4	1	6
26	R:R:Y274	5.9775	4	0	8
27	R:R:I278	1.8725	4	0	5
28	R:R:F296	6.8075	4	4	4
29	R:R:Y303	10.006	5	1	6
30	R:R:N309	6.9075	4	2	9
31	R:R:L312	2.135	4	8	8
32	R:R:Y313	5.305	4	2	9
33	R:R:F320	4.965	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:G124	10.7791	6.61	Yes	No	0	0	4
2	L:L:?1	L:L:?4	35.1009	8.1	Yes	Yes	1	0	0
3	L:L:?4	R:R:F273	42.1281	3.74	Yes	Yes	1	0	6
4	L:L:?1	R:R:D123	17.8795	6.47	Yes	Yes	1	0	6
5	R:R:D123	R:R:Y303	33.0761	4.6	Yes	Yes	1	6	6
6	L:L:?4	R:R:Y303	53.5401	8.4	Yes	Yes	1	0	6
7	R:R:L97	R:R:Y303	23.0736	9.38	No	Yes	0	6	6
8	R:R:L97	R:R:Y51	18.0257	5.86	No	Yes	0	6	7
9	R:R:I47	R:R:Y51	10.3001	6.04	Yes	Yes	4	6	7
10	L:L:?1	R:R:F99	17.6652	4.64	Yes	Yes	1	0	5
11	R:R:F273	R:R:Y274	61.9869	7.22	Yes	Yes	0	6	8
12	R:R:W270	R:R:Y274	61.6011	3.86	Yes	Yes	0	8	8
13	R:R:N305	R:R:W270	44.3419	6.78	No	Yes	0	9	8
14	R:R:N305	R:R:N309	40.9279	9.54	No	Yes	0	9	9
15	R:R:N309	R:R:Y313	68.7191	5.81	Yes	Yes	2	9	9
16	R:R:R141	R:R:Y313	100	7.2	No	Yes	0	9	9
17	R:R:M137	R:R:R141	98.5325	12.41	No	No	0	8	9
18	R:R:M137	R:R:Y82	96.9339	3.59	No	Yes	0	8	7
19	R:R:V78	R:R:Y82	40.2194	7.57	Yes	Yes	3	6	7
20	R:R:R155	R:R:V78	38.6813	6.54	Yes	Yes	3	7	6
21	R:R:R155	R:R:T79	70.2269	3.88	Yes	No	0	7	7
22	R:R:I83	R:R:T79	45.9531	3.04	No	No	0	8	7
23	R:R:F320	R:R:I83	42.4281	5.02	Yes	No	0	8	8
24	R:R:F320	R:R:V68	32.0852	6.55	Yes	No	0	8	7
25	R:R:F324	R:R:V68	21.4347	6.55	No	No	0	5	7
26	R:R:F315	R:R:F324	17.8744	5.36	No	No	0	6	5
27	R:R:F315	R:R:L64	14.3091	7.31	No	No	0	6	5
28	R:R:G61	R:R:L64	10.7388	1.71	No	No	0	7	5
29	R:R:F93	R:R:Y303	69.2385	21.66	No	Yes	0	7	6
30	R:R:F93	R:R:S306	68.1795	7.93	No	No	0	7	8
31	R:R:D90	R:R:S306	68.0761	4.42	Yes	No	0	9	8
32	R:R:D90	R:R:N309	37.6072	4.04	Yes	Yes	2	9	9
33	R:R:D90	R:R:L86	34.1704	8.14	Yes	No	2	9	9
34	R:R:L86	R:R:Y313	33.1114	3.52	No	Yes	2	9	9
35	R:R:D140	R:R:Y82	40.2219	8.05	No	Yes	3	8	7
36	R:R:D140	R:R:R155	38.5124	13.1	No	Yes	3	8	7
37	R:R:R319	R:R:T79	21.1674	6.47	No	No	0	6	7
38	R:R:R319	R:R:S77	10.7337	5.27	No	No	0	6	8
39	L:L:?2	R:R:F128	41.0565	4.71	Yes	Yes	0	0	6
40	R:R:F128	R:R:S171	28.6183	3.96	Yes	No	0	6	8
41	R:R:S171	R:R:T129	15.7312	4.8	No	No	0	8	7
42	R:R:T129	R:R:W168	10.5068	16.98	No	No	0	7	9
43	R:R:F99	R:R:W109	10.2874	5.01	Yes	Yes	1	5	8
44	L:L:?1	R:R:Q103	13.1467	8.88	Yes	No	1	0	5
45	R:R:Q103	R:R:W109	10.3404	7.67	No	Yes	1	5	8
46	R:R:F111	R:R:W109	15	19.04	No	Yes	0	6	8
47	R:R:F111	R:R:P110	17.9097	2.89	No	No	0	6	2
48	L:L:?1	R:R:V119	10.3707	8.52	Yes	No	1	0	5
49	R:R:P110	R:R:Y108	13.4392	8.34	No	No	0	2	4
50	L:L:?1	R:R:M120	17.8921	14.82	Yes	No	0	0	4
51	R:R:M120	R:R:R117	15.1765	3.72	No	No	0	4	6
52	R:R:R117	R:R:V184	13.6813	6.54	No	Yes	0	6	4
53	R:R:F128	R:R:V175	12.9576	5.24	Yes	No	0	6	7
54	R:R:I125	R:R:V175	17.6021	4.61	No	No	0	5	7
55	R:R:I125	R:R:S171	10.4917	4.64	No	No	0	5	8
56	R:R:F266	R:R:W270	35.4236	18.04	No	Yes	0	9	8
57	R:R:F266	R:R:L219	34.7832	9.74	No	Yes	0	9	5
58	R:R:I222	R:R:L219	31.7221	2.85	No	Yes	0	8	5
59	R:R:I222	R:R:S138	27.6475	6.19	No	No	0	8	9
60	R:R:C225	R:R:S138	26.9415	3.44	No	No	0	7	9
61	R:R:C225	R:R:Y142	26.2305	6.72	No	Yes	0	7	8
62	R:R:V146	R:R:Y142	17.8543	6.31	No	Yes	7	6	8
63	R:R:I229	R:R:V146	17.2995	1.54	No	No	0	8	6
64	L:L:?2	L:L:?3	15.532	26.76	Yes	Yes	1	0	0
65	R:R:I229	R:R:V233	15.7413	1.54	No	No	0	8	8
66	R:R:E252	R:R:V233	14.9496	5.7	No	No	0	6	8
67	R:R:E252	R:R:G237	12.6248	1.64	No	No	0	6	4
68	R:R:G237	R:R:V240	11.0111	1.84	No	No	0	4	5
69	R:R:V240	R:R:W241	10.1941	8.58	No	Yes	0	5	3
70	R:R:I125	R:R:L176	21.0262	2.85	No	No	0	5	4
71	R:R:F128	R:R:Q127	18.0434	3.51	Yes	No	0	6	7
72	L:L:?2	R:R:D123	15.0429	5.25	Yes	Yes	1	0	6
73	L:L:?2	L:L:?4	27.1054	25.55	Yes	Yes	1	0	0
74	L:L:?3	R:R:F273	19.8538	4.57	Yes	Yes	1	0	6
75	L:L:?4	R:R:Q127	18.8931	4.09	Yes	No	0	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F99	4.64	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L100	18.47	1	Yes	No	0	7	0	1
L:L:?1	R:R:Q103	8.88	1	Yes	No	0	5	0	1
L:L:?1	R:R:V119	8.52	1	Yes	No	0	5	0	1
L:L:?1	R:R:M120	14.82	1	Yes	No	0	4	0	1
L:L:?1	R:R:D123	6.47	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:D123	5.25	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:G124	6.61	1	Yes	No	0	4	0	1
L:L:?2	R:R:F128	4.71	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:V179	3.84	1	Yes	No	0	5	0	1
L:L:?2	R:R:M193	5.47	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:F206	17.27	1	Yes	Yes	0	5	0	1
L:L:?3	R:R:M193	3.98	1	Yes	Yes	0	4	0	1
L:L:?3	R:R:W195	3.2	1	Yes	Yes	0	6	0	1
L:L:?3	R:R:F206	3.43	1	Yes	Yes	0	5	0	1
L:L:?3	R:R:F273	4.57	1	Yes	Yes	0	6	0	1
L:L:?3	R:R:N277	3.86	1	Yes	No	0	6	0	1
L:L:?4	R:R:D123	6.94	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:Q127	4.09	1	Yes	No	0	7	0	1
L:L:?4	R:R:F273	3.74	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:Y295	3.6	1	Yes	No	0	4	0	1
L:L:?4	R:R:V299	13.72	1	Yes	No	0	5	0	1
L:L:?4	R:R:Y303	8.4	1	Yes	Yes	0	6	0	1
R:R:F93	R:R:Y303	21.66	0	No	Yes	7	6	2	1
R:R:M94	R:R:Y303	5.99	0	No	Yes	6	6	2	1
R:R:L97	R:R:Y303	9.38	0	No	Yes	6	6	2	1
R:R:F99	R:R:W109	5.01	1	Yes	Yes	5	8	1	2
R:R:F99	R:R:V119	10.49	1	Yes	No	5	5	1	1
R:R:Q103	R:R:W109	7.67	1	No	Yes	5	8	1	2
R:R:C191	R:R:Q103	9.16	1	No	No	9	5	2	1
R:R:C116	R:R:W109	3.92	1	No	Yes	9	8	2	2
R:R:C191	R:R:W109	11.75	1	No	Yes	9	8	2	2
R:R:M115	R:R:V119	3.04	0	No	No	5	5	2	1
R:R:C116	R:R:M120	4.86	1	No	No	9	4	2	1
R:R:C116	R:R:C191	5.46	1	No	No	9	9	2	2
R:R:M120	R:R:R117	3.72	0	No	No	4	6	1	2
R:R:D123	R:R:Y303	4.6	1	Yes	Yes	6	6	1	1
R:R:G124	R:R:V175	3.68	0	No	No	4	7	1	2
R:R:F128	R:R:Q127	3.51	0	Yes	No	6	7	1	1
R:R:F128	R:R:F132	3.22	0	Yes	No	6	5	1	2
R:R:F128	R:R:S171	3.96	0	Yes	No	6	8	1	2
R:R:F128	R:R:V174	7.87	0	Yes	No	6	5	1	2
R:R:F128	R:R:V175	5.24	0	Yes	No	6	7	1	2
R:R:M193	R:R:S182	4.6	1	Yes	No	4	5	1	2
R:R:S182	R:R:W195	3.71	1	No	Yes	5	6	2	1
R:R:M193	R:R:W195	9.31	1	Yes	Yes	4	6	1	1
R:R:R203	R:R:W195	15.99	0	No	Yes	4	6	2	1
R:R:F206	R:R:W195	11.02	1	Yes	Yes	5	6	1	1
R:R:F273	R:R:Y274	7.22	1	Yes	Yes	6	8	1	2
R:R:F273	R:R:N277	15.71	1	Yes	No	6	6	1	1
R:R:L276	R:R:Y295	7.03	0	No	No	4	4	2	1
R:R:F99	R:R:G96	3.01	1	Yes	No	5	6	1	2
R:R:I207	R:R:I278	2.94	0	No	Yes	5	5	1	2
R:R:W195	R:R:W202	2.81	1	Yes	No	6	1	1	2
L:L:?3	R:R:I207	2.68	1	Yes	No	0	5	0	1
R:R:F206	R:R:V178	2.62	1	Yes	No	5	4	1	2
R:R:A121	R:R:V179	1.7	0	No	No	5	5	2	1
R:R:V179	R:R:V180	1.6	0	No	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XIQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	269
Number of Links	298
Number of Hubs	33
Number of Links mediated by Hubs	132
Number of Communities	8
Number of Nodes involved in Communities	47
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	79989
Length Of Smallest Path	3
Average Path Length	15.268
Length of Longest Path	38
Minimum Path Strength	1.405
Average Path Strength	6.95918
Maximum Path Strength	24.7133
Minimum Path Correlation	0.7
Average Path Correlation	0.931085
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	46.6693
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.6629
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIT
Name	4-NITROANILINE
Synonyms	PARANITROANILINE
Identifier
Formula	C6 H6 N2 O2
Molecular Weight	138.124
SMILES
PubChem	7475
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	16
Total Aromatic Bonds	6


Code	FC0
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	FC0
Name	N-CARBOXY-L-PHENYLALANINE
Synonyms
Identifier
Formula	C10 H11 N O4
Molecular Weight	209.199
SMILES
PubChem	20637693
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	NLE
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	A1D
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32745
Sequence	>8XIQ_nogp_Chain_R L A V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H T A S P S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S Y W P F G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H P T R S A R W R T A P V A R T V S A A V W V A S A V V V L P V V V F S G V P R G M S T C H M Q W P E P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V W A P S C Q R R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C P L P E E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F K Q G F R R V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XIQ	A	Peptide	Somatostatin	SST3	Homo sapiens	L796778	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.71	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIQ (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	L796778	-		2.71	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIR	A	Peptide	Somatostatin	SST3	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.52	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIR (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	Pasireotide	-		2.52	2024-07-03	doi.org/10.1073/pnas.2400298121
	8ZBI	A	Peptide	Somatostatin	SST3	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.79	2025-04-30	To be published
	8ZBI (No Gprot)	A	Peptide	Somatostatin	SST3	Homo sapiens	Somatostatin-14	-		2.79	2025-04-30	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XIQ_nogp.zip

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