psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H19	R:R:C30	2.95	Yes	No	7	0	4
2	L:L:C22	R:R:C30	7.28	No	No	7	0	4
3	L:L:H19	R:R:N31	3.83	Yes	No	0	0	6
4	R:R:F32	R:R:S33	5.28	No	No	0	3	6
5	L:L:I18	R:R:F32	15.07	No	No	0	0	3
6	L:L:N46	R:R:L34	5.49	No	No	0	0	2
7	L:L:R48	R:R:E35	13.96	No	No	0	0	3
8	L:L:L15	R:R:V36	5.96	No	No	0	0	3
9	R:R:E40	R:R:V38	4.28	No	No	0	4	4
10	L:L:C51	R:R:V38	5.12	Yes	No	0	0	4
11	R:R:C286	R:R:C39	7.28	No	No	0	8	8
12	R:R:C39	R:R:R289	4.18	No	No	0	8	3
13	R:R:E40	R:R:M41	10.83	No	No	0	4	2
14	L:L:K49	R:R:E40	6.75	No	No	0	0	4
15	R:R:C286	R:R:T42	3.38	No	No	0	8	3
16	R:R:P46	R:R:V45	3.53	No	No	0	2	4
17	R:R:V294	R:R:V45	3.21	No	No	0	3	4
18	R:R:A297	R:R:V45	5.09	No	No	0	5	4
19	R:R:P46	R:R:W49	4.05	No	No	0	2	5
20	R:R:V51	R:R:Y47	6.31	No	No	8	5	4
21	R:R:E103	R:R:Y47	7.86	No	No	8	6	4
22	R:R:F107	R:R:Y47	5.16	No	No	0	5	4
23	R:R:I53	R:R:W49	4.7	No	No	0	5	5
24	R:R:L301	R:R:N50	6.87	Yes	No	0	5	4
25	R:R:E103	R:R:V51	5.7	No	No	8	6	5
26	R:R:G52	R:R:S55	3.71	No	No	0	5	6
27	R:R:I53	R:R:L301	7.14	No	Yes	0	5	5
28	R:R:L100	R:R:L54	2.77	No	Yes	0	8	7
29	R:R:E103	R:R:L54	3.98	No	Yes	0	6	7
30	R:R:L301	R:R:L54	2.77	Yes	Yes	0	5	7
31	L:L:A1	R:R:L54	3.15	No	Yes	0	0	7
32	R:R:I57	R:R:L305	5.71	No	No	0	7	4
33	R:R:F58	R:R:V62	6.55	No	No	0	7	5
34	R:R:F58	R:R:S97	3.96	No	No	0	7	6
35	R:R:F58	R:R:L100	4.87	No	No	0	7	8
36	R:R:N61	R:R:N65	6.81	Yes	No	0	9	9
37	R:R:L96	R:R:N61	6.87	No	Yes	2	8	9
38	R:R:N61	R:R:Y128	3.49	Yes	Yes	2	9	9
39	R:R:A308	R:R:N61	4.69	No	Yes	0	7	9
40	R:R:G64	R:R:L312	5.13	No	No	0	8	6
41	R:R:C90	R:R:N65	4.72	No	No	0	8	9
42	R:R:N65	R:R:P311	4.89	No	No	0	9	9
43	R:R:I71	R:R:L67	2.85	No	No	5	6	7
44	R:R:F321	R:R:L67	3.65	Yes	No	5	8	7
45	R:R:L67	R:R:M325	5.65	No	No	0	7	5
46	R:R:S315	R:R:V68	3.23	Yes	No	5	7	9
47	R:R:F321	R:R:V68	2.62	Yes	No	5	8	9
48	R:R:L87	R:R:T69	2.95	No	No	0	6	6
49	R:R:K74	R:R:Y70	13.14	No	No	0	4	4
50	R:R:L328	R:R:Y70	3.52	No	No	0	6	4
51	R:R:F321	R:R:I71	7.54	Yes	No	5	8	6
52	R:R:I71	R:R:L328	2.85	No	No	0	6	6
53	R:R:A79	R:R:F72	4.16	No	No	0	5	6
54	R:R:F72	R:R:L87	10.96	No	No	0	6	6
55	R:R:H75	R:R:K74	3.93	No	No	0	4	4
56	R:R:H75	R:R:R324	25.95	No	No	0	4	5
57	R:R:A79	R:R:D83	4.63	No	No	0	5	7
58	R:R:A81	R:R:V142	3.39	No	No	0	7	9
59	R:R:I82	R:R:L86	2.85	No	No	0	8	7
60	R:R:I82	R:R:V139	7.68	No	No	0	8	8
61	R:R:I82	R:R:V142	7.68	No	No	0	8	9
62	R:R:I84	R:R:Q158	5.49	No	No	0	6	3
63	R:R:I84	R:R:W162	9.4	No	No	0	6	3
64	R:R:C138	R:R:L85	4.76	No	Yes	9	6	6
65	R:R:L85	R:R:V139	2.98	Yes	No	0	6	8
66	R:R:L164	R:R:L85	2.77	No	Yes	9	5	6
67	R:R:L85	R:R:T165	4.42	Yes	No	0	6	6
68	R:R:C90	R:R:L87	3.17	No	No	0	8	6
69	R:R:I89	R:R:N92	4.25	Yes	Yes	2	9	8
70	R:R:D132	R:R:I89	7	Yes	Yes	2	9	9
71	R:R:I89	R:R:S135	6.19	Yes	No	0	9	7
72	R:R:I89	R:R:P311	5.08	Yes	No	0	9	9
73	R:R:L91	R:R:W169	5.69	No	Yes	0	5	9
74	R:R:N92	R:R:Y128	6.98	Yes	Yes	2	8	9
75	R:R:L131	R:R:N92	5.49	Yes	Yes	0	7	8
76	R:R:D132	R:R:N92	6.73	Yes	Yes	2	9	8
77	R:R:C95	R:R:F124	2.79	No	No	0	6	4
78	R:R:C95	R:R:L127	3.17	No	Yes	0	6	5
79	R:R:L96	R:R:S99	4.5	No	No	0	8	7
80	R:R:L96	R:R:Y128	14.07	No	Yes	2	8	9
81	R:R:F124	R:R:I98	7.54	No	No	0	4	4
82	R:R:L101	R:R:L105	2.77	No	No	0	9	4
83	R:R:A102	R:R:E121	3.02	No	No	0	7	5
84	R:R:I113	R:R:M106	5.83	No	No	0	8	6
85	R:R:L117	R:R:M106	4.24	No	No	0	5	6
86	R:R:F109	R:R:L108	12.18	Yes	No	0	4	4
87	R:R:N111	R:R:P110	6.52	No	No	0	9	4
88	R:R:R185	R:R:T115	2.59	No	No	0	5	3
89	R:R:G116	R:R:R119	4.5	No	No	0	2	8
90	R:R:L117	R:R:L120	5.54	No	No	0	5	4
91	R:R:C118	R:R:R183	4.18	No	Yes	3	9	6
92	R:R:C118	R:R:C196	7.28	No	No	3	9	9
93	R:R:F124	R:R:L120	6.09	No	No	0	4	4
94	R:R:E121	R:R:I122	8.2	No	Yes	0	5	6
95	L:L:S2	R:R:E121	5.75	No	No	0	0	5
96	R:R:I122	R:R:Y126	3.63	Yes	Yes	3	6	5
97	R:R:I122	R:R:R183	16.28	Yes	Yes	3	6	6
98	L:L:V3	R:R:I122	3.07	No	Yes	3	0	6
99	R:R:F123	R:R:S176	5.28	No	No	0	5	7
100	R:R:F123	R:R:G177	3.01	No	No	0	5	3
101	R:R:C180	R:R:F123	5.59	No	No	0	4	5
102	R:R:V129	R:R:Y125	7.57	No	Yes	0	7	6
103	R:R:S300	R:R:Y125	3.82	No	Yes	0	7	6
104	L:L:A1	R:R:Y125	6.67	No	Yes	0	0	6
105	L:L:V3	R:R:Y125	5.05	No	Yes	0	0	6
106	R:R:Y126	R:R:Y130	5.96	Yes	Yes	0	5	8
107	R:R:S176	R:R:Y126	2.54	No	Yes	0	7	5
108	R:R:A179	R:R:Y126	5.34	No	Yes	0	5	5
109	L:L:V3	R:R:Y126	7.57	No	Yes	3	0	5
110	R:R:L127	R:R:W169	4.56	Yes	Yes	10	5	9
111	R:R:L127	R:R:L173	4.15	Yes	No	10	5	3
112	R:R:L127	R:R:S176	6.01	Yes	No	0	5	7
113	R:R:S307	R:R:Y128	5.09	No	Yes	0	8	9
114	R:R:V129	R:R:Y130	5.05	No	Yes	0	7	8
115	R:R:L175	R:R:Y130	3.52	No	Yes	0	5	8
116	R:R:S215	R:R:Y130	3.82	No	Yes	0	6	8
117	R:R:L131	R:R:S135	3	Yes	No	0	7	7
118	R:R:L131	R:R:W169	13.67	Yes	Yes	0	7	9
119	R:R:A172	R:R:L131	3.15	No	Yes	0	7	7
120	R:R:D132	R:R:S307	5.89	Yes	No	0	9	8
121	R:R:D132	R:R:V310	10.22	Yes	Yes	0	9	9
122	R:R:I133	R:R:P223	3.39	No	Yes	0	8	9
123	R:R:F260	R:R:I133	5.02	Yes	No	0	9	8
124	R:R:F134	R:R:I171	8.79	No	No	0	6	4
125	R:R:V136	R:R:Y314	6.31	No	Yes	0	8	9
126	R:R:L226	R:R:V137	2.98	No	No	0	6	7
127	R:R:C138	R:R:L164	6.35	No	No	9	6	5
128	R:R:R143	R:R:V139	3.92	No	No	0	9	8
129	R:R:L227	R:R:S140	6.01	No	No	12	8	9
130	R:R:F230	R:R:S140	6.61	Yes	No	0	8	9
131	R:R:S140	R:R:Y231	6.36	No	Yes	12	9	9
132	R:R:L141	R:R:L145	4.15	No	No	0	5	6
133	R:R:F230	R:R:L141	9.74	Yes	No	0	8	5
134	R:R:R143	R:R:Y231	6.17	No	Yes	0	9	9
135	R:R:R143	R:R:Y314	3.09	No	Yes	0	9	9
136	R:R:A148	R:R:Y144	5.34	No	Yes	0	7	8
137	R:R:F230	R:R:Y144	4.13	Yes	Yes	0	8	8
138	R:R:L233	R:R:Y144	10.55	No	Yes	0	4	8
139	R:R:T234	R:R:Y144	3.75	No	Yes	0	8	8
140	R:R:T234	R:R:V147	4.76	No	Yes	0	8	8
141	R:R:V147	R:R:V237	3.21	Yes	No	0	8	6
142	R:R:A148	R:R:Y149	2.67	No	No	0	7	6
143	R:R:W154	R:R:Y149	2.89	Yes	No	0	5	6
144	R:R:R152	R:R:T151	3.88	No	No	0	4	5
145	R:R:R152	R:R:W154	13.99	No	Yes	0	4	5
146	R:R:P155	R:R:W154	10.81	No	Yes	0	3	5
147	R:R:K157	R:R:S159	4.59	No	No	0	6	4
148	R:R:L160	R:R:L164	5.54	No	No	0	3	5
149	R:R:L173	R:R:W169	3.42	No	Yes	10	3	9
150	R:R:D178	R:R:R181	5.96	No	No	0	8	4
151	R:R:D178	R:R:V214	2.92	No	No	0	8	4
152	R:R:H182	R:R:R181	11.28	No	No	6	5	4
153	R:R:R181	R:R:W207	11	No	Yes	6	4	4
154	R:R:A200	R:R:H182	8.78	No	No	6	5	5
155	R:R:H182	R:R:W207	15.87	No	Yes	6	5	4
156	R:R:C196	R:R:R183	2.79	No	Yes	3	9	6
157	R:R:E198	R:R:R183	11.63	No	Yes	0	5	6
158	R:R:D188	R:R:V186	2.92	Yes	No	1	1	1
159	R:R:V186	R:R:Y197	6.31	No	Yes	1	1	4
160	L:L:P33	R:R:V186	5.3	Yes	No	1	0	1
161	R:R:D188	R:R:P189	3.22	Yes	Yes	1	1	2
162	R:R:D188	R:R:K192	12.44	Yes	No	1	1	5
163	L:L:L7	R:R:D188	5.43	No	Yes	0	0	1
164	R:R:K192	R:R:P189	3.35	No	Yes	1	5	2
165	L:L:Q10	R:R:P189	4.74	No	Yes	1	0	2
166	L:L:K29	R:R:P189	3.35	Yes	Yes	1	0	2
167	R:R:S191	R:R:V190	4.85	No	No	0	3	1
168	R:R:Q193	R:R:V190	2.87	No	No	0	2	1
169	R:R:R208	R:R:Y197	5.14	Yes	Yes	1	4	4
170	L:L:L7	R:R:Y197	10.55	No	Yes	0	0	4
171	L:L:P33	R:R:Y197	2.78	Yes	Yes	1	0	4
172	R:R:E198	R:R:W207	5.45	No	Yes	0	5	4
173	R:R:E198	R:R:R208	4.65	No	Yes	0	5	4
174	L:L:P33	R:R:N199	4.89	Yes	No	0	0	4
175	R:R:A200	R:R:T204	3.36	No	No	0	5	3
176	R:R:A200	R:R:W207	3.89	No	Yes	6	5	4
177	R:R:H210	R:R:W207	4.23	No	Yes	0	3	4
178	R:R:R208	R:R:R212	3.2	Yes	Yes	1	4	5
179	L:L:E6	R:R:R208	10.47	Yes	Yes	1	0	4
180	R:R:L209	R:R:T275	2.95	No	No	0	2	5
181	R:R:H210	R:R:V214	6.92	No	No	0	3	4
182	R:R:N271	R:R:R212	8.44	No	Yes	0	5	5
183	R:R:D274	R:R:R212	9.53	Yes	Yes	1	5	5
184	R:R:R212	R:R:T275	6.47	Yes	No	0	5	5
185	L:L:E6	R:R:R212	4.65	Yes	Yes	1	0	5
186	R:R:H268	R:R:S215	2.79	Yes	No	0	9	6
187	R:R:H268	R:R:V216	9.69	Yes	No	0	9	5
188	R:R:G219	R:R:P223	4.06	No	Yes	0	7	9
189	R:R:F220	R:R:F261	4.29	No	No	13	9	5
190	R:R:F220	R:R:F265	9.65	No	Yes	13	9	5
191	R:R:F220	R:R:H268	5.66	No	Yes	0	9	9
192	R:R:L222	R:R:P223	3.28	No	Yes	0	6	9
193	R:R:F260	R:R:L224	3.65	Yes	No	0	9	6
194	R:R:F230	R:R:L226	3.65	Yes	No	0	8	6
195	R:R:L227	R:R:Y231	9.38	No	Yes	12	8	9
196	R:R:L227	R:R:V257	5.96	No	No	0	8	7
197	R:R:L229	R:R:L233	2.77	No	No	0	4	4
198	R:R:I253	R:R:Y231	15.71	No	Yes	0	7	9
199	R:R:V256	R:R:Y231	3.79	Yes	Yes	0	7	9
200	R:R:R239	R:R:W235	6	No	Yes	0	4	5
201	R:R:R246	R:R:W235	3	No	Yes	0	7	5
202	R:R:V249	R:R:W235	3.68	No	Yes	0	6	5
203	R:R:R250	R:R:W235	15.99	No	Yes	0	6	5
204	R:R:C236	R:R:R239	4.18	No	No	0	3	4
205	R:R:L243	R:R:T241	2.95	No	No	0	3	6
206	R:R:I253	R:R:V249	3.07	No	No	0	7	6
207	R:R:V256	R:R:Y314	10.09	Yes	Yes	0	7	9
208	R:R:F263	R:R:L259	6.09	Yes	No	0	8	6
209	R:R:I313	R:R:L259	4.28	No	No	0	8	6
210	R:R:C264	R:R:F260	8.38	No	Yes	11	9	9
211	R:R:F260	R:R:Y306	6.19	Yes	Yes	11	9	9
212	R:R:F261	R:R:F265	13.93	No	Yes	13	5	5
213	R:R:F263	R:R:V262	2.62	Yes	No	0	8	4
214	R:R:F263	R:R:L302	4.87	Yes	No	0	8	6
215	R:R:F263	R:R:Y306	8.25	Yes	Yes	0	8	9
216	R:R:C264	R:R:Y306	2.69	No	Yes	11	9	9
217	R:R:F265	R:R:P266	2.89	Yes	No	0	5	9
218	R:R:F265	R:R:V269	7.87	Yes	No	0	5	5
219	R:R:H268	R:R:Y267	4.36	Yes	Yes	0	9	7
220	R:R:N271	R:R:Y267	18.61	No	Yes	0	5	7
221	R:R:T299	R:R:Y267	6.24	No	Yes	0	8	7
222	R:R:Q303	R:R:Y267	9.02	No	Yes	0	8	7
223	R:R:L296	R:R:N271	2.75	No	No	0	4	5
224	R:R:L272	R:R:T275	2.95	No	No	0	5	5
225	R:R:L272	R:R:L276	5.54	No	No	0	5	5
226	R:R:D274	R:R:R278	8.34	Yes	No	1	5	4
227	R:R:D274	R:R:I292	4.2	Yes	No	0	5	5
228	L:L:R8	R:R:D274	8.34	Yes	Yes	1	0	5
229	R:R:L276	R:R:W281	5.69	No	No	0	5	2
230	R:R:I282	R:R:L276	4.28	No	No	0	3	5
231	R:R:I292	R:R:L277	4.28	No	No	0	5	3
232	L:L:E6	R:R:R278	4.65	Yes	No	1	0	4
233	L:L:R8	R:R:R278	3.2	Yes	No	1	0	4
234	R:R:R279	R:R:W281	17.99	No	No	0	3	2
235	R:R:D284	R:R:R280	7.15	No	No	0	1	2
236	L:L:L12	R:R:D284	13.57	No	No	0	0	1
237	R:R:S285	R:R:T288	9.59	No	No	0	4	3
238	R:R:L291	R:R:Y287	4.69	No	No	0	4	2
239	L:L:R8	R:R:R289	9.6	Yes	No	0	0	3
240	L:L:L12	R:R:R289	3.64	No	No	0	0	3
241	L:L:E6	R:R:N293	2.63	Yes	No	1	0	4
242	L:L:R8	R:R:N293	8.44	Yes	No	1	0	4
243	L:L:E6	R:R:L296	6.63	Yes	No	0	0	4
244	R:R:L301	R:R:S300	3	Yes	No	0	5	7
245	L:L:A4	R:R:S300	3.42	No	No	0	0	7
246	R:R:L305	R:R:V309	4.47	No	No	0	4	6
247	R:R:V310	R:R:Y306	10.09	Yes	Yes	0	9	9
248	R:R:P311	R:R:V310	5.3	No	Yes	0	9	9
249	R:R:F321	R:R:S315	14.53	Yes	Yes	5	8	7
250	R:R:L320	R:R:R324	13.36	No	No	0	6	5
251	R:R:R322	R:R:Y326	3.09	No	No	0	8	4
252	R:R:G327	R:R:Q330	3.29	No	No	0	4	5
253	L:L:S2	L:L:T5	3.2	No	No	0	0	0
254	L:L:E6	L:L:R8	4.65	Yes	Yes	1	0	0
255	L:L:H34	L:L:L7	2.57	No	No	0	0	0
256	L:L:C35	L:L:C9	7.28	No	No	0	0	0
257	L:L:K29	L:L:Q10	5.42	Yes	No	1	0	0
258	L:L:E39	L:L:Q10	5.1	No	No	0	0	0
259	L:L:C11	L:L:E39	10.64	No	No	0	0	0
260	L:L:C11	L:L:I41	4.91	No	Yes	1	0	0
261	L:L:C11	L:L:C51	7.28	No	Yes	1	0	0
262	L:L:G17	L:L:Q16	3.29	No	No	0	0	0
263	L:L:N53	L:L:Q16	5.28	Yes	No	4	0	0
264	L:L:Q16	L:L:S56	4.33	No	Yes	4	0	0
265	L:L:I18	L:L:I23	2.94	No	No	0	0	0
266	L:L:H19	L:L:P20	9.15	Yes	No	0	0	0
267	L:L:H19	L:L:K21	2.62	Yes	No	0	0	0
268	L:L:C22	L:L:H19	5.9	No	Yes	7	0	0
269	L:L:I23	L:L:L44	2.85	No	No	0	0	0
270	L:L:Q24	L:L:S25	2.89	No	No	0	0	0
271	L:L:K45	L:L:Q24	8.14	No	No	0	0	0
272	L:L:K29	L:L:N27	5.6	Yes	No	1	0	0
273	L:L:I41	L:L:N27	4.25	Yes	No	1	0	0
274	L:L:I41	L:L:K29	2.91	Yes	Yes	1	0	0
275	L:L:P31	L:L:S30	3.56	No	No	0	0	0
276	L:L:P31	L:L:T38	3.5	No	No	0	0	0
277	L:L:G32	L:L:P33	4.06	No	Yes	0	0	0
278	L:L:C35	L:L:H34	2.95	No	No	0	0	0
279	L:L:C35	L:L:Q37	4.58	No	No	0	0	0
280	L:L:P54	L:L:T38	3.5	No	No	0	0	0
281	L:L:L52	L:L:V40	5.96	No	No	0	0	0
282	L:L:C51	L:L:I41	6.55	Yes	Yes	1	0	0
283	L:L:A42	L:L:L52	3.15	No	No	0	0	0
284	L:L:K49	L:L:T43	3	No	No	0	0	0
285	L:L:L44	L:L:N46	6.87	No	No	0	0	0
286	L:L:N53	L:L:S56	8.94	Yes	Yes	4	0	0
287	L:L:N53	L:L:V59	7.39	Yes	No	4	0	0
288	L:L:P57	L:L:S56	3.56	No	Yes	4	0	0
289	L:L:I58	L:L:S56	3.1	No	Yes	4	0	0
290	L:L:S56	L:L:V59	6.46	Yes	No	4	0	0
291	L:L:I58	L:L:P57	3.39	No	No	4	0	0
292	L:L:I58	L:L:I62	4.42	No	No	0	0	0
293	L:L:I62	L:L:M66	4.37	No	No	0	0	0
294	L:L:I63	L:L:L67	4.28	No	No	0	0	0
295	L:L:E64	L:L:K71	4.05	No	No	0	0	0
296	L:L:K71	L:L:L67	2.82	No	No	0	0	0
297	L:L:N68	L:L:S72	4.47	No	No	0	0	0
298	R:R:V310	R:R:Y314	2.52	Yes	Yes	0	9	9
299	R:R:F109	R:R:I112	2.51	Yes	No	0	4	3
300	R:R:I113	R:R:R185	2.51	No	No	0	8	5
301	R:R:F109	R:R:L105	2.44	Yes	No	0	4	4
302	R:R:A81	R:R:G161	1.95	No	No	0	7	7
303	R:R:G116	R:R:S114	1.86	No	No	0	2	7
304	R:R:G295	R:R:V294	1.84	No	No	0	6	3
305	R:R:G295	R:R:V298	1.84	No	No	0	6	6
306	R:R:G290	R:R:T42	1.82	No	No	0	3	3
307	R:R:G290	R:R:T43	1.82	No	No	0	3	4
308	R:R:G66	R:R:T69	1.82	No	No	0	3	6
309	R:R:G88	R:R:T165	1.82	No	No	0	9	6
310	R:R:G80	R:R:I84	1.76	No	No	0	7	6
311	R:R:C316	R:R:S315	1.72	No	Yes	0	7	7
312	R:R:G64	R:R:L63	1.71	No	No	0	8	3
313	R:R:C90	R:R:V68	1.71	No	No	0	8	9
314	R:R:A168	R:R:S135	1.71	No	No	0	6	7
315	R:R:G295	R:R:L270	1.71	No	No	0	6	5
316	R:R:A179	R:R:V211	1.7	No	No	0	5	5
317	R:R:C73	R:R:T69	1.69	No	No	0	2	6
318	R:R:D83	R:R:G80	1.68	No	No	0	7	7
319	R:R:A218	R:R:T217	1.68	No	No	0	4	4
320	L:L:N53	L:L:P54	1.63	Yes	No	0	0	0
321	R:R:A304	R:R:I57	1.62	No	No	0	7	7
322	R:R:A308	R:R:I57	1.62	No	No	0	7	7
323	R:R:A308	R:R:I60	1.62	No	No	0	7	5
324	R:R:S93	R:R:V62	1.62	No	No	0	9	5
325	R:R:A194	R:R:I113	1.62	No	No	0	4	8
326	L:L:A50	L:L:I18	1.62	No	No	0	0	0
327	R:R:V36	R:R:V38	1.6	No	No	0	3	4
328	R:R:V147	R:R:V238	1.6	Yes	No	0	8	8
329	R:R:V252	R:R:V256	1.6	No	Yes	0	6	7
330	R:R:V254	R:R:V258	1.6	No	No	0	4	4
331	R:R:V258	R:R:V262	1.6	No	No	0	4	4
332	L:L:S25	L:L:T43	1.6	No	No	0	0	0
333	R:R:T217	R:R:V216	1.59	No	No	0	4	5
334	R:R:A245	R:R:L243	1.58	No	No	0	5	3
335	L:L:A50	L:L:L15	1.58	No	No	0	0	0
336	R:R:I228	R:R:V257	1.54	No	No	0	4	7
337	L:L:C51	L:L:Q13	1.53	Yes	No	0	0	0
338	L:L:K71	L:L:S72	1.53	No	No	0	0	0
339	R:R:A194	R:R:Q193	1.52	No	No	0	4	2
340	R:R:K248	R:R:V252	1.52	No	No	0	7	6
341	L:L:K60	L:L:V59	1.52	No	No	0	0	0
342	R:R:L94	R:R:S97	1.5	No	No	0	7	6
343	R:R:L117	R:R:S114	1.5	No	No	0	5	7
344	R:R:G251	R:R:R250	1.5	No	No	0	5	6
345	R:R:L312	R:R:S315	1.5	No	Yes	0	6	7
346	L:L:G47	L:L:R48	1.5	No	No	0	0	0
347	R:R:L105	R:R:V104	1.49	No	No	0	4	7
348	R:R:L146	R:R:V142	1.49	No	No	0	7	9
349	R:R:L146	R:R:V147	1.49	No	Yes	0	7	8
350	R:R:N199	R:R:S184	1.49	No	No	0	4	4
351	R:R:L317	R:R:V256	1.49	No	Yes	0	6	7
352	R:R:L273	R:R:V269	1.49	No	No	0	6	5
353	R:R:N293	R:R:V44	1.48	No	No	0	4	4
354	R:R:L221	R:R:T217	1.47	No	No	0	4	4
355	R:R:G327	R:R:Y326	1.45	No	No	0	4	4
356	R:R:F109	R:R:P110	1.44	Yes	No	0	4	4
357	R:R:F134	R:R:P223	1.44	No	Yes	0	6	9
358	R:R:Q330	R:R:S331	1.44	No	No	0	5	5
359	R:R:I98	R:R:L101	1.43	No	No	0	4	9
360	R:R:Q193	R:R:V187	1.43	No	No	0	2	2
361	L:L:L67	L:L:M66	1.41	No	No	0	0	0
362	R:R:L59	R:R:L63	1.38	No	No	0	4	3
363	R:R:E35	R:R:L34	1.33	No	No	0	3	2
364	R:R:L320	R:R:Q323	1.33	No	No	0	6	4
365	R:R:S285	R:R:Y287	1.27	No	No	0	4	2
366	R:R:K157	R:R:W154	1.16	No	Yes	0	6	5
367	R:R:H75	R:R:R78	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L54	3.1675	4	0	7
2	R:R:N61	5.465	4	2	9
3	R:R:L85	3.7325	4	9	6
4	R:R:I89	5.63	4	2	9
5	R:R:N92	5.8625	4	2	8
6	R:R:F109	4.6425	4	0	4
7	R:R:I122	7.795	4	3	6
8	R:R:Y125	5.7775	4	0	6
9	R:R:Y126	5.008	5	3	5
10	R:R:L127	4.4725	4	10	5
11	R:R:Y128	7.4075	4	2	9
12	R:R:Y130	4.5875	4	0	8
13	R:R:L131	6.3275	4	0	7
14	R:R:D132	7.46	4	2	9
15	R:R:Y144	5.9425	4	0	8
16	R:R:V147	2.765	4	0	8
17	R:R:W154	7.2125	4	0	5
18	R:R:W169	6.835	4	10	9
19	R:R:R183	8.72	4	3	6
20	R:R:D188	6.0025	4	1	1
21	R:R:P189	3.665	4	1	2
22	R:R:Y197	6.195	4	1	4
23	R:R:W207	8.088	5	6	4
24	R:R:R208	5.865	4	1	4
25	R:R:R212	6.458	5	1	5
26	R:R:P223	3.0425	4	0	9
27	R:R:F230	6.0325	4	0	8
28	R:R:Y231	8.282	5	12	9
29	R:R:W235	7.1675	4	0	5
30	R:R:V256	4.2425	4	0	7
31	R:R:F260	5.81	4	11	9
32	R:R:F263	5.4575	4	0	8
33	R:R:F265	8.585	4	13	5
34	R:R:Y267	9.5575	4	0	7
35	R:R:H268	5.625	4	0	9
36	R:R:D274	7.6025	4	1	5
37	R:R:L301	4.945	4	0	5
38	R:R:Y306	6.805	4	11	9
39	R:R:V310	7.0325	4	0	9
40	R:R:Y314	5.5025	4	0	9
41	R:R:S315	5.245	4	5	7
42	R:R:F321	7.085	4	5	8
43	L:L:E6	5.61333	6	1	0
44	L:L:R8	6.846	5	1	0
45	L:L:H19	4.89	5	7	0
46	L:L:K29	4.32	4	1	0
47	L:L:P33	4.2575	4	1	0
48	L:L:I41	4.655	4	1	0
49	L:L:C51	5.12	4	1	0
50	L:L:N53	5.81	4	4	0
51	L:L:S56	5.278	5	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I18	L:L:I23	11.4444	2.94	No	No	0	0	0
2	L:L:A50	L:L:L15	17.8845	1.58	No	No	0	0	0
3	L:L:A50	L:L:I18	16.2806	1.62	No	No	0	0	0
4	L:L:L15	R:R:V36	19.4861	5.96	No	No	0	0	3
5	R:R:E40	R:R:V38	11.4444	4.28	No	No	0	4	4
6	R:R:V36	R:R:V38	21.081	1.6	No	No	0	3	4
7	L:L:C51	R:R:V38	33.679	5.12	Yes	No	0	0	4
8	L:L:E6	R:R:R208	12.7906	10.47	Yes	Yes	1	0	4
9	R:R:R208	R:R:Y197	59.5963	5.14	Yes	Yes	1	4	4
10	R:R:V186	R:R:Y197	26.3832	6.31	No	Yes	1	1	4
11	R:R:D188	R:R:V186	25.9755	2.92	Yes	No	1	1	1
12	R:R:D188	R:R:P189	48.8733	3.22	Yes	Yes	1	1	2
13	L:L:K29	R:R:P189	42.6751	3.35	Yes	Yes	1	0	2
14	L:L:I41	L:L:K29	39.6712	2.91	Yes	Yes	1	0	0
15	L:L:C51	L:L:I41	36.6292	6.55	Yes	Yes	1	0	0
16	L:L:L7	R:R:Y197	29.5641	10.55	No	Yes	0	0	4
17	L:L:L7	R:R:D188	26.0024	5.43	No	Yes	0	0	1
18	R:R:E198	R:R:R208	70.7406	4.65	No	Yes	0	5	4
19	R:R:E198	R:R:R183	74.2888	11.63	No	Yes	0	5	6
20	R:R:I122	R:R:R183	75.5387	16.28	Yes	Yes	3	6	6
21	L:L:V3	R:R:Y125	22.2011	5.05	No	Yes	0	0	6
22	R:R:S300	R:R:Y125	11.5922	3.82	No	Yes	0	7	6
23	L:L:A1	R:R:Y125	10.7007	6.67	No	Yes	0	0	6
24	R:R:I122	R:R:Y126	70.0349	3.63	Yes	Yes	3	6	5
25	R:R:S176	R:R:Y126	96.4451	2.54	No	Yes	0	7	5
26	R:R:L127	R:R:S176	97.135	6.01	Yes	No	0	5	7
27	R:R:L127	R:R:W169	99.4221	4.56	Yes	Yes	10	5	9
28	R:R:L131	R:R:W169	100	13.67	Yes	Yes	0	7	9
29	R:R:L131	R:R:N92	83.5088	5.49	Yes	Yes	0	7	8
30	R:R:N92	R:R:Y128	20.7383	6.98	Yes	Yes	2	8	9
31	R:R:N61	R:R:Y128	18.3549	3.49	Yes	Yes	2	9	9
32	R:R:I89	R:R:N92	15.8237	4.25	Yes	Yes	2	9	8
33	R:R:I89	R:R:P311	31.5264	5.08	Yes	No	0	9	9
34	R:R:N65	R:R:P311	39.3284	4.89	No	No	0	9	9
35	R:R:L131	R:R:S135	16.6458	3	Yes	No	0	7	7
36	R:R:I89	R:R:S135	16.8205	6.19	Yes	No	0	9	7
37	R:R:N61	R:R:N65	17.7165	6.81	Yes	No	0	9	9
38	R:R:C90	R:R:N65	51.2522	4.72	No	No	0	8	9
39	R:R:C90	R:R:V68	31.8982	1.71	No	No	0	8	9
40	R:R:S315	R:R:V68	10.1048	3.23	Yes	No	5	7	9
41	R:R:F321	R:R:V68	20.1469	2.62	Yes	No	5	8	9
42	R:R:F321	R:R:I71	15.2681	7.54	Yes	No	5	8	6
43	R:R:C90	R:R:L87	18.6999	3.17	No	No	0	8	6
44	R:R:I71	R:R:L328	13.6195	2.85	No	No	0	6	6
45	R:R:L328	R:R:Y70	11.9573	3.52	No	No	0	6	4
46	R:R:K74	R:R:Y70	10.2639	13.14	No	No	0	4	4
47	R:R:A79	R:R:F72	10.2661	4.16	No	No	0	5	6
48	R:R:F72	R:R:L87	11.9618	10.96	No	No	0	6	6
49	R:R:R143	R:R:V139	11.0367	3.92	No	No	0	9	8
50	R:R:R143	R:R:Y314	29.8822	3.09	No	Yes	0	9	9
51	R:R:V310	R:R:Y314	52.1751	2.52	Yes	Yes	0	9	9
52	R:R:D132	R:R:V310	49.3616	10.22	Yes	Yes	0	9	9
53	R:R:D132	R:R:N92	48.4253	6.73	Yes	Yes	2	9	8
54	R:R:C95	R:R:L127	22.2862	3.17	No	Yes	0	6	5
55	R:R:C95	R:R:F124	21.4484	2.79	No	No	0	6	4
56	R:R:F124	R:R:L120	12.8242	6.09	No	No	0	4	4
57	R:R:L117	R:R:L120	11.9372	5.54	No	No	0	5	4
58	R:R:Y126	R:R:Y130	12.4636	5.96	Yes	Yes	0	5	8
59	R:R:R208	R:R:R212	12.4255	3.2	Yes	Yes	1	4	5
60	R:R:H268	R:R:S215	11.0994	2.79	Yes	No	0	9	6
61	R:R:V310	R:R:Y306	13.2118	10.09	Yes	Yes	0	9	9
62	R:R:R143	R:R:Y231	19.8535	6.17	No	Yes	0	9	9
63	R:R:S140	R:R:Y231	23.7713	6.36	No	Yes	12	9	9
64	R:R:F230	R:R:S140	22.6334	6.61	Yes	No	0	8	9
65	R:R:V256	R:R:Y314	21.6366	10.09	Yes	Yes	0	7	9
66	R:R:V256	R:R:Y231	19.4122	3.79	Yes	Yes	0	7	9
67	R:R:A148	R:R:Y144	10.9112	5.34	No	Yes	0	7	8
68	R:R:F230	R:R:Y144	16.2045	4.13	Yes	Yes	0	8	8
69	R:R:I253	R:R:Y231	10.9112	15.71	No	Yes	0	7	9
70	R:R:S215	R:R:Y130	11.4533	3.82	No	Yes	0	6	8
71	L:L:V3	R:R:Y126	15.4608	7.57	No	Yes	3	0	5
72	R:R:P311	R:R:V310	10.2325	5.3	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H19	R:R:C30	2.95	7	Yes	No	0	4	0	1
L:L:C22	R:R:C30	7.28	7	No	No	0	4	0	1
L:L:H19	R:R:N31	3.83	7	Yes	No	0	6	0	1
R:R:F32	R:R:S33	5.28	0	No	No	3	6	1	2
L:L:I18	R:R:F32	15.07	0	No	No	0	3	0	1
L:L:N46	R:R:L34	5.49	0	No	No	0	2	0	1
L:L:R48	R:R:E35	13.96	0	No	No	0	3	0	1
L:L:L15	R:R:V36	5.96	0	No	No	0	3	0	1
R:R:E40	R:R:V38	4.28	0	No	No	4	4	1	1
L:L:C51	R:R:V38	5.12	1	Yes	No	0	4	0	1
R:R:C39	R:R:R289	4.18	0	No	No	8	3	2	1
R:R:E40	R:R:M41	10.83	0	No	No	4	2	1	2
L:L:K49	R:R:E40	6.75	0	No	No	0	4	0	1
R:R:L100	R:R:L54	2.77	0	No	Yes	8	7	2	1
R:R:E103	R:R:L54	3.98	8	No	Yes	6	7	2	1
R:R:L301	R:R:L54	2.77	0	Yes	Yes	5	7	2	1
L:L:A1	R:R:L54	3.15	0	No	Yes	0	7	0	1
R:R:A102	R:R:E121	3.02	0	No	No	7	5	2	1
R:R:E121	R:R:I122	8.2	0	No	Yes	5	6	1	1
L:L:S2	R:R:E121	5.75	0	No	No	0	5	0	1
R:R:I122	R:R:Y126	3.63	3	Yes	Yes	6	5	1	1
R:R:I122	R:R:R183	16.28	3	Yes	Yes	6	6	1	2
L:L:V3	R:R:I122	3.07	3	No	Yes	0	6	0	1
R:R:V129	R:R:Y125	7.57	0	No	Yes	7	6	2	1
R:R:S300	R:R:Y125	3.82	0	No	Yes	7	6	1	1
L:L:A1	R:R:Y125	6.67	0	No	Yes	0	6	0	1
L:L:V3	R:R:Y125	5.05	3	No	Yes	0	6	0	1
R:R:Y126	R:R:Y130	5.96	3	Yes	Yes	5	8	1	2
R:R:S176	R:R:Y126	2.54	0	No	Yes	7	5	2	1
R:R:A179	R:R:Y126	5.34	0	No	Yes	5	5	2	1
L:L:V3	R:R:Y126	7.57	3	No	Yes	0	5	0	1
R:R:V129	R:R:Y130	5.05	0	No	Yes	7	8	2	2
R:R:E198	R:R:R183	11.63	0	No	Yes	5	6	2	2
R:R:D188	R:R:V186	2.92	1	Yes	No	1	1	1	1
R:R:V186	R:R:Y197	6.31	1	No	Yes	1	4	1	1
L:L:P33	R:R:V186	5.3	1	Yes	No	0	1	0	1
R:R:D188	R:R:P189	3.22	1	Yes	Yes	1	2	1	1
R:R:D188	R:R:K192	12.44	1	Yes	No	1	5	1	2
L:L:L7	R:R:D188	5.43	0	No	Yes	0	1	0	1
R:R:K192	R:R:P189	3.35	1	No	Yes	5	2	2	1
L:L:Q10	R:R:P189	4.74	1	No	Yes	0	2	0	1
L:L:K29	R:R:P189	3.35	1	Yes	Yes	0	2	0	1
R:R:R208	R:R:Y197	5.14	1	Yes	Yes	4	4	1	1
L:L:L7	R:R:Y197	10.55	0	No	Yes	0	4	0	1
L:L:P33	R:R:Y197	2.78	1	Yes	Yes	0	4	0	1
R:R:E198	R:R:R208	4.65	0	No	Yes	5	4	2	1
L:L:P33	R:R:N199	4.89	1	Yes	No	0	4	0	1
R:R:R208	R:R:R212	3.2	1	Yes	Yes	4	5	1	1
L:L:E6	R:R:R208	10.47	1	Yes	Yes	0	4	0	1
R:R:N271	R:R:R212	8.44	0	No	Yes	5	5	2	1
R:R:D274	R:R:R212	9.53	1	Yes	Yes	5	5	1	1
R:R:R212	R:R:T275	6.47	1	Yes	No	5	5	1	2
L:L:E6	R:R:R212	4.65	1	Yes	Yes	0	5	0	1
R:R:L296	R:R:N271	2.75	0	No	No	4	5	1	2
R:R:D274	R:R:R278	8.34	1	Yes	No	5	4	1	1
R:R:D274	R:R:I292	4.2	1	Yes	No	5	5	1	2
L:L:R8	R:R:D274	8.34	1	Yes	Yes	0	5	0	1
L:L:E6	R:R:R278	4.65	1	Yes	No	0	4	0	1
L:L:R8	R:R:R278	3.2	1	Yes	No	0	4	0	1
R:R:D284	R:R:R280	7.15	0	No	No	1	2	1	2
L:L:L12	R:R:D284	13.57	0	No	No	0	1	0	1
L:L:R8	R:R:R289	9.6	1	Yes	No	0	3	0	1
L:L:L12	R:R:R289	3.64	0	No	No	0	3	0	1
L:L:E6	R:R:N293	2.63	1	Yes	No	0	4	0	1
L:L:R8	R:R:N293	8.44	1	Yes	No	0	4	0	1
L:L:E6	R:R:L296	6.63	1	Yes	No	0	4	0	1
R:R:L301	R:R:S300	3	0	Yes	No	5	7	2	1
L:L:A4	R:R:S300	3.42	0	No	No	0	7	0	1
R:R:V36	R:R:V38	1.6	0	No	No	3	4	1	1
R:R:N199	R:R:S184	1.49	0	No	No	4	4	1	2
R:R:N293	R:R:V44	1.48	1	No	No	4	4	1	2
R:R:E35	R:R:L34	1.33	0	No	No	3	2	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EJC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.54
Number of Linked Nodes	334
Number of Links	367
Number of Hubs	51
Number of Links mediated by Hubs	178
Number of Communities	13
Number of Nodes involved in Communities	67
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	74467
Length Of Smallest Path	3
Average Path Length	17.9533
Length of Longest Path	43
Minimum Path Strength	1.475
Average Path Strength	5.76907
Maximum Path Strength	19.655
Minimum Path Correlation	0.7
Average Path Correlation	0.949991
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	54.5285
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.7788
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q98146
Sequence	>9EJC_nogp_Chain_R C N F S L E V S V C E M T T V V P Y T W N V G I L S L I F L I N V L G N G L V T Y I F C K H R S R A G A I D I L L L G I C L N S L C L S I S L L A E V L M F L F P N I I S T G L C R L E I F F Y Y L Y V Y L D I F S V V C V S L V R Y L L V A Y S T R S W P K K Q S L G W V L T S A A W L I A L V L S G D A C R H R S R V V D P V S K Q A M C Y E N A G N M T A D W R L H V R T V S V T A G F L L P L A L L I L F Y A L T W C V V R R T K L Q A R R K V R G V I V A V V V L F F V F C F P Y H V L N L L D T L L R R R W I R D S C Y T R G L I N V G L A V T S L L Q A L Y S A V V P L I Y S C L G S L F R Q R M Y G L F Q S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9EJC	A	Other	Uclassified	ORF74	Human gammaherpesvirus 8	CXCL1	-	Gi1/β1/γ2	2.98	2025-09-03	doi.org/10.1038/s41467-025-63457-4
	9EJC (No Gprot)	A	Other	Uclassified	ORF74	Human gammaherpesvirus 8	CXCL1	-		2.98	2025-09-03	doi.org/10.1038/s41467-025-63457-4
	8W1A	A	Other	Uclassified	ORF74	Human gammaherpesvirus 8	-	-	-	2.89	2025-08-27	To be published

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Download 9EJC_nogp.zip

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