Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.875475
2A:A:S44 3.69469
3A:A:H188 7.33413
4A:A:F191 8.6475475
5A:A:F196 7.036577
6A:A:K197 10.8525416
7A:A:F199 7.324515
8A:A:Q204 4.87419
9A:A:S206 4.385418
10A:A:R208 4.1675409
11A:A:K210 7.15667619
12A:A:W211 5.158519
13A:A:H213 5.825418
14A:A:C214 3.99417
15A:A:F215 4.91833619
16A:A:I221 5.494228
17A:A:R242 94179
18A:A:W258 6.154515
19A:A:F267 6.41469
20A:A:L268 4.3354138
21A:A:I278 3.685406
22A:A:L283 3.36407
23A:A:Y287 3.16407
24A:A:E318 6.4845244
25A:A:Y320 7.26507
26A:A:T321 6.44254135
27A:A:T324 7.26469
28A:A:N331 4.8525468
29A:A:F336 5.006578
30A:A:F354 4.618505
31B:B:L7 3.9275408
32B:B:Q13 3.285401
33B:B:L14 5.4575408
34B:B:I18 4.346507
35B:B:D27 7.16754268
36B:B:L30 5.83754115
37B:B:T34 3.725405
38B:B:I37 4.1175492
39B:B:V40 4.35167693
40B:B:M45 4.975404
41B:B:H54 8.18714729
42B:B:Y59 7.3975418
43B:B:W63 6.255627
44B:B:V71 4.7425488
45B:B:D76 4.79529
46B:B:L79 4.8125487
47B:B:I80 9.3428
48B:B:I81 3.826587
49B:B:W82 9.02875829
50B:B:N88 5.8354217
51B:B:K89 6.45714729
52B:B:H91 5.6325405
53B:B:I93 4.8825407
54B:B:L95 4.894588
55B:B:W99 7.20167619
56B:B:M101 3.5875419
57B:B:Y105 4.5875886
58B:B:N110 7.15254104
59B:B:Y111 5.875104
60B:B:N119 3.71409
61B:B:Y124 5.8125406
62B:B:L126 3.44485
63B:B:T128 2.91754103
64B:B:H142 6.75649
65B:B:Y145 4.83286718
66B:B:F151 5.415409
67B:B:T159 4.69833649
68B:B:S160 5.2456
69B:B:D163 7.7375449
70B:B:T165 4.732547
71B:B:C166 3.6975458
72B:B:W169 9.33548
73B:B:F180 5.6625457
74B:B:H183 7.972559
75B:B:D186 5.196519
76B:B:V187 5.7775459
77B:B:F199 5.85167659
78B:B:S201 4.6075459
79B:B:C204 4.355417
80B:B:K209 10.595456
81B:B:L210 5.935405
82B:B:W211 6.26667658
83B:B:D212 8.57254199
84B:B:Q220 7.0575417
85B:B:F222 7.57418
86B:B:H225 8.90286719
87B:B:D228 5.976519
88B:B:I232 5.405418
89B:B:F234 5.76405
90B:B:F235 6.746156
91B:B:P236 6.73754157
92B:B:F241 7.845416
93B:B:T243 4.59718
94B:B:D246 4.67419
95B:B:D247 6.186519
96B:B:T249 5.2875416
97B:B:R251 7.75667618
98B:B:F253 7.028516
99B:B:L261 3.4554115
100B:B:M262 5.3754114
101B:B:Y264 6.348505
102B:B:I273 5.44754126
103B:B:F278 5.913336157
104B:B:R283 6.44699
105B:B:L285 5.325406
106B:B:Y289 6.66127
107B:B:D290 10.09406
108B:B:N295 6.514126
109B:B:V296 3.12405
110B:B:K301 3.9125405
111B:B:L308 7.145407
112B:B:H311 9.275409
113B:B:M325 5.44425
114B:B:T329 5.3625408
115B:B:W332 11.5229719
116B:B:F335 5.1354284
117B:B:L336 4.0775427
118B:B:W339 7.365279
119B:B:N340 5.575429
120G:G:K20 5.2925406
121G:G:Y40 6.29254156
122G:G:D48 6.162599
123G:G:L51 3.338596
124G:G:N59 6.8725429
125G:G:P60 8.315429
126G:G:F61 4.845828
127R:R:R8 5402
128R:R:M18 4.646535
129R:R:L22 6.065437
130R:R:Y53 6.78407
131R:R:F55 6.11406
132R:R:N56 6.88254169
133R:R:Y74 8.575435
134R:R:Y75 8.532535
135R:R:R79 6.61435
136R:R:W81 7.915638
137R:R:I103 5.285408
138R:R:F105 7.2985167
139R:R:R113 4.195409
140R:R:Y114 6.176209
141R:R:K116 4.848336148
142R:R:V118 6.13754207
143R:R:W140 7.40254169
144R:R:F168 6.71434
145R:R:M170 5.596533
146R:R:H177 10.93435
147R:R:F181 5.37667635
148R:R:K198 4.73254204
149R:R:L209 4.6454242
150R:R:I222 3.446507
151R:R:Y233 7.0025409
152R:R:V237 8.435438
153R:R:R240 8.08167635
154R:R:S250 3.3725432
155R:R:D253 3.7175402
156R:R:H261 6.3125435
157R:R:F266 3.62254297
158R:R:T267 5.2275408
159R:R:M269 3.885404
160R:R:D274 6.7825409
161R:R:Y278 6.324509
162R:R:S282 2.7675408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I222 R:R:R113 47.91232.51YesYes079
2A:A:L353 R:R:I222 48.14157.14NoYes077
3A:A:L348 A:A:L353 48.37564.15NoNo097
4A:A:F354 A:A:L348 50.76663.65YesNo059
5A:A:F354 R:R:M215 51.80582.49YesNo057
6R:R:L209 R:R:M215 52.03445.65YesNo027
7A:A:E318 R:R:L209 51.89535.3YesYes2442
8A:A:E318 A:A:Y320 52.643514.59YesYes047
9A:A:F334 A:A:Y320 54.16454.13NoYes037
10A:A:F334 A:A:H322 54.27457.92NoNo039
11A:A:H322 A:A:T324 54.15342.74NoYes699
12A:A:I49 A:A:T324 54.16654.56NoYes679
13A:A:C224 A:A:I49 57.89011.64NoNo677
14A:A:C224 A:A:S44 55.25935.16NoYes679
15A:A:A41 A:A:S44 56.00311.71NoYes079
16A:A:A41 A:A:S246 56.09471.71NoNo079
17A:A:S246 A:A:V225 56.18966.46NoNo097
18A:A:F307 A:A:V225 56.28613.93NoNo087
19A:A:F250 A:A:F307 56.3837.5NoNo098
20A:A:F223 A:A:F250 57.559715NoNo099
21A:A:F223 A:A:L249 66.3747.31NoNo099
22A:A:L249 A:A:R208 66.45473.64NoYes099
23A:A:R208 A:A:W211 66.24994YesYes099
24A:A:S206 A:A:W211 37.62624.94YesYes189
25A:A:S206 B:B:D186 52.20435.89YesYes189
26B:B:C204 B:B:D186 68.19173.11YesYes179
27B:B:C204 B:B:D228 84.33876.22YesYes179
28B:B:D228 B:B:D246 41.12695.32YesYes199
29B:B:D246 B:B:G272 59.32815.03YesNo094
30B:B:D290 B:B:G272 59.14943.35YesNo064
31B:B:C271 B:B:D290 93.6056.22NoYes056
32B:B:C271 B:B:Y289 92.98414.03NoYes057
33B:B:N295 B:B:Y289 69.97738.14YesYes1267
34B:B:N295 B:B:V307 69.31492.96YesNo1263
35B:B:G306 B:B:V307 69.02991.84NoNo043
36B:B:G306 B:B:V296 68.70181.84NoYes045
37B:B:L308 B:B:V296 57.35532.98YesYes075
38B:B:L308 B:B:M45 40.72189.9YesYes074
39B:B:M45 B:B:N340 37.51182.8YesYes049
40B:B:N340 G:G:F61 32.60593.62YesYes298
41B:B:S84 G:G:F61 15.62823.96NoYes058
42A:A:F215 A:A:W211 19.47484.01YesYes199
43A:A:F215 B:B:W99 16.93765.01YesYes199
44B:B:Q75 B:B:W99 17.28828.76NoYes199
45B:B:Q75 B:B:Y59 16.798411.27NoYes198
46B:B:W332 B:B:Y59 23.29132.89YesYes198
47B:B:R314 B:B:W332 29.604719.99NoYes189
48B:B:D290 B:B:R314 36.531925.01YesNo068
49B:B:H62 B:B:Y105 51.51743.27NoYes066
50B:B:H62 B:B:R150 52.43137.9NoNo066
51B:B:C148 B:B:R150 53.34515.57NoNo066
52B:B:C148 B:B:T102 54.25873.38NoNo068
53B:B:C149 B:B:T102 55.1725.07NoNo088
54B:B:C149 B:B:T159 56.07243.38NoYes489
55B:B:H142 B:B:T159 86.0325.48YesYes499
56B:B:H142 B:B:S161 47.564915.34YesNo499
57B:B:D163 B:B:S161 48.01127.36YesNo499
58B:B:D163 B:B:G144 98.26373.35YesNo098
59B:B:G144 B:B:N119 98.69813.39NoYes089
60A:A:Q204 B:B:N119 1006.6YesYes099
61A:A:Q204 A:A:S206 15.38912.89YesYes198
62B:B:H142 B:B:T165 47.59762.74YesYes497
63B:B:D163 B:B:T165 49.38313.01YesYes497
64A:A:Q204 B:B:Y145 73.34074.51YesYes198
65B:B:D186 B:B:Y145 16.33268.05YesYes198
66B:B:M188 B:B:Y145 39.43594.79NoYes188
67B:B:C204 B:B:M188 16.32193.24YesNo178
68A:A:K210 B:B:M188 23.143210.08YesNo198
69A:A:K210 B:B:D228 16.43418.3YesYes199
70B:B:M101 B:B:Y145 21.52584.79YesYes198
71A:A:C214 B:B:M101 21.13563.24YesYes179
72A:A:C214 A:A:H213 14.32772.95YesYes178
73A:A:F223 A:A:L266 10.55253.65NoNo099
74B:B:D246 B:B:S227 11.79612.94YesNo196
75B:B:D247 B:B:S227 71.34622.94YesNo196
76B:B:D247 B:B:H225 53.71066.3YesYes199
77B:B:H225 B:B:T243 36.24886.85YesYes198
78B:B:F241 B:B:T243 16.27112.59YesYes168
79B:B:F222 B:B:F241 16.109710.72YesYes186
80B:B:D258 B:B:F222 60.54167.17NoYes178
81B:B:D258 B:B:R22 59.934213.1NoNo076
82B:B:I18 B:B:R22 59.1843.76YesNo076
83B:B:I18 B:B:Q17 22.97675.49YesNo074
84B:B:L14 B:B:Q17 22.21392.66YesNo084
85B:B:L14 B:B:Q13 16.10357.99YesYes081
86B:B:F253 B:B:T243 16.27287.78YesYes168
87B:B:F222 B:B:F253 48.2155.36YesYes186
88B:B:H225 B:B:R251 16.801320.31YesYes198
89B:B:F253 B:B:R251 32.48213.21YesYes168
90B:B:D247 B:B:T249 17.149811.56YesYes196
91B:B:R251 B:B:T249 16.79793.88YesYes186
92B:B:I18 G:G:E22 34.39445.47YesNo079
93B:B:R49 G:G:F61 12.89735.34NoYes078
94B:B:L51 B:B:W82 10.309522.78NoYes299
95B:B:L51 B:B:T87 11.78122.95NoNo095
96B:B:H311 B:B:S331 11.887216.74YesNo099
97B:B:D333 B:B:S331 10.40157.36NoNo099
98B:B:L70 B:B:W82 10.69496.83NoYes259
99B:B:S84 B:B:W63 12.79444.94NoYes057
100B:B:I157 B:B:T159 28.59653.04NoYes079
101B:B:I157 B:B:I171 27.67722.94NoNo076
102B:B:I123 B:B:I171 20.3155.89NoNo066
103B:B:V71 B:B:Y105 29.45756.31YesYes886
104B:B:L79 B:B:V71 27.63534.47YesYes878
105B:B:L79 B:B:L95 12.90094.15YesYes878
106B:B:I93 B:B:L79 11.05914.28YesYes077
107B:B:L126 B:B:Y105 12.88793.52YesYes856
108B:B:L126 B:B:V133 11.97522.98YesNo054
109B:B:I93 B:B:V133 11.06734.61YesNo074
110B:B:I93 B:B:Y124 18.43347.25YesYes076
111B:B:S122 B:B:Y124 22.11915.09NoYes086
112B:B:E138 B:B:S122 19.35495.75NoNo068
113B:B:E138 B:B:I120 13.8268.2NoNo066
114B:B:I123 B:B:Y111 12.93953.63NoYes064
115G:G:E22 G:G:Q18 33.63472.55NoNo099
116B:B:C218 G:G:Q18 32.87489.16NoNo059
117B:B:C218 B:B:K209 10.704811.32NoYes556
118B:B:C218 B:B:W211 21.40973.92NoYes558
119B:B:F199 B:B:W211 10.725912.03YesYes598
120B:B:W297 B:B:Y289 21.34647.72NoYes087
121B:B:W297 B:B:Y264 21.28639.65NoYes085
122B:B:L285 B:B:Y264 10.37778.21YesYes065
123R:R:R113 R:R:Y278 41.3136.17YesYes099
124R:R:D274 R:R:Y278 35.2978.05YesYes099
125R:R:D274 R:R:D61 30.24523.99YesNo099
126R:R:D61 R:R:S271 29.85295.89NoNo099
127R:R:L64 R:R:S271 29.7093NoNo079
128R:R:L64 R:R:L68 29.42214.15NoNo078
129R:R:L22 R:R:L68 29.13624.15YesNo078
130R:R:L22 R:R:Y75 15.61027.03YesYes375
131R:R:R71 R:R:Y75 10.860815.43NoYes365
132R:R:L95 R:R:R71 11.15383.64NoNo066
133R:R:L95 R:R:Y268 10.99434.69NoNo067
134R:R:L264 R:R:Y268 10.835214.07NoNo067
135R:R:L264 R:R:T267 10.67728.84NoYes068
136R:R:T267 R:R:Y233 11.17594.99YesYes089
137R:R:L22 R:R:M18 13.24024.24YesYes375
138R:R:H261 R:R:M18 12.05872.63YesYes355
139R:R:F105 R:R:L57 10.29086.09YesNo079
140A:A:Q204 A:A:W211 13.30665.48YesYes199
141B:B:R49 B:B:T87 12.15193.88NoNo075
142B:B:L70 B:B:W63 11.05049.11NoYes257
143B:B:D228 B:B:S227 59.69845.89YesNo196
144B:B:M262 B:B:Y264 10.68087.18YesYes045
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9J8Z
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic acid
SubType HCA1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.36
Date 2025-04-02
D.O.I. To be published
Net Summary
Imin 2.55
Number of Linked Nodes 848
Number of Links 1019
Number of Hubs 162
Number of Links mediated by Hubs 591
Number of Communities 29
Number of Nodes involved in Communities 249
Number of Links involved in Communities 356
Path Summary
Number Of Nodes in MetaPath 145
Number Of Links MetaPath 144
Number of Shortest Paths 1856061
Length Of Smallest Path 3
Average Path Length 33.7848
Length of Longest Path 78
Minimum Path Strength 1.215
Average Path Strength 5.75399
Maximum Path Strength 27.98
Minimum Path Correlation 0.7
Average Path Correlation 0.986342
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 43.9209
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.2703
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • negative regulation of catabolic process   • lipid catabolic process   • catabolic process   • regulation of lipid metabolic process   • negative regulation of metabolic process   • negative regulation of biological process   • primary metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • regulation of primary metabolic process   • negative regulation of cellular process   • metabolic process   • regulation of metabolic process   • negative regulation of lipid metabolic process   • negative regulation of lipid catabolic process   • lipid metabolic process   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>9J8Z_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVNRMHESM KLFDSICNN KWFTDTSII LFLNKKDLF 
EEKIKKSPL TICYPEYAG SNTYEEAAA YIQCQFEDL NKRKDTKEI 
YTHFTCTDT KNVQFVFDA VTDVIIKNN LKDCGLFAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9J8Z_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9J8Z_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9BXC0
Sequence
>9J8Z_Chain_R
CCRIEGDTI SQVMPPLLI VAFVLGALG NGVALCGFC FHMKTWKPS 
TVYLFNLAV ADFLLMICL PFRTDYYLR RRHWAFGDI PCRVGLFTL 
AMNRAGSIV FLTVVAADR YFKVVHPHH AVNTISTRV AAGIVCTLW 
ALVILGTVY LLLENHLCV QETAVSCES FIMESANGW HDIMFQLEF 
FMPLGIILF CSFKIVWSL RRRQQLARQ ARMKKATRF IMVVAIVFI 
TCYLPSVSA RLYFLWTVP SSACDPSVH GALHITLSF TYMNSMLDP 
LVYYFSSPS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IZDAAlicarboxylic acidHydroxycarboxylic acidHCA1Homo sapiensCHBA-Gi1/β1/γ23.162025-04-02To be published
9IZD (No Gprot) AAlicarboxylic acidHydroxycarboxylic acidHCA1Homo sapiensCHBA-3.162025-04-02To be published
9J8Z (No Gprot) AAlicarboxylic acidHydroxycarboxylic acidHCA1Homo sapiens--3.362025-04-02To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9J8Z.zip



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