psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C6	R:R:R8	5.57	No	Yes	0	6	2
2	R:R:C157	R:R:C6	7.28	No	No	0	3	6
3	R:R:C252	R:R:C7	7.28	No	No	0	7	6
4	R:R:Q159	R:R:R8	3.5	No	Yes	0	3	2
5	R:R:E160	R:R:R8	6.98	No	Yes	0	2	2
6	R:R:R8	R:R:S164	3.95	Yes	No	0	2	4
7	R:R:G11	R:R:I9	3.53	No	No	0	4	4
8	R:R:E10	R:R:R79	5.82	No	Yes	0	4	5
9	R:R:E10	R:R:H257	4.92	No	No	0	4	4
10	R:R:D12	R:R:G11	3.35	No	No	0	4	4
11	R:R:D12	R:R:T13	13.01	No	No	0	4	3
12	R:R:Q16	R:R:T13	7.09	No	No	0	3	3
13	R:R:I14	R:R:M18	5.83	No	Yes	0	4	5
14	R:R:I262	R:R:V17	3.07	No	No	0	5	5
15	R:R:M18	R:R:P19	3.35	Yes	No	0	5	6
16	R:R:L22	R:R:M18	4.24	Yes	Yes	1	7	5
17	R:R:M18	R:R:Y75	7.18	Yes	Yes	1	5	5
18	R:R:P19	R:R:P20	5.84	No	No	0	6	4
19	R:R:L76	R:R:P19	3.28	No	No	0	3	6
20	R:R:L22	R:R:L68	4.15	Yes	No	0	7	8
21	R:R:L22	R:R:T72	8.84	Yes	No	0	7	7
22	R:R:L22	R:R:Y75	7.03	Yes	Yes	1	7	5
23	R:R:A25	R:R:M272	4.83	No	No	0	7	8
24	R:R:F26	R:R:V27	7.87	No	No	0	7	6
25	R:R:F26	R:R:M65	7.46	No	No	0	7	6
26	R:R:L28	R:R:M272	8.48	No	No	0	5	8
27	R:R:G29	R:R:N33	3.39	No	No	0	8	9
28	R:R:A30	R:R:M65	4.83	No	No	0	5	6
29	R:R:G32	R:R:V35	3.68	No	No	0	7	5
30	R:R:D61	R:R:N33	5.39	No	No	0	9	9
31	R:R:N33	R:R:P275	13.03	No	No	0	9	9
32	R:R:A58	R:R:L37	3.15	No	No	0	8	8
33	R:R:F62	R:R:L37	4.87	No	No	0	7	8
34	R:R:G39	R:R:H43	4.77	No	No	0	8	5
35	R:R:F40	R:R:L54	4.87	No	No	0	7	8
36	R:R:F40	R:R:F55	10.72	No	Yes	0	7	6
37	R:R:F42	R:R:H43	7.92	No	No	0	4	5
38	R:R:M44	R:R:S284	9.2	No	No	0	6	6
39	R:R:T51	R:R:W47	3.64	No	No	0	8	6
40	R:R:K48	R:R:P49	8.36	No	No	0	7	7
41	R:R:D112	R:R:S50	8.83	No	No	4	8	7
42	R:R:K116	R:R:S50	6.12	No	No	4	8	7
43	R:R:V52	R:R:Y53	7.57	No	Yes	0	7	7
44	R:R:N56	R:R:V52	4.43	Yes	No	0	9	7
45	R:R:V108	R:R:Y53	8.83	No	Yes	0	6	7
46	R:R:D112	R:R:Y53	8.05	No	Yes	0	8	7
47	R:R:F55	R:R:N56	6.04	Yes	Yes	0	6	9
48	R:R:F55	R:R:V59	5.24	Yes	No	0	6	5
49	R:R:F105	R:R:N56	9.67	Yes	Yes	5	7	9
50	R:R:N56	R:R:V136	7.39	Yes	No	5	9	7
51	R:R:F105	R:R:L57	6.09	Yes	No	0	7	9
52	R:R:L106	R:R:L57	4.15	No	No	0	8	9
53	R:R:D274	R:R:L57	5.43	Yes	No	0	9	9
54	R:R:D61	R:R:S271	5.89	No	No	0	9	9
55	R:R:D274	R:R:D61	3.99	Yes	No	0	9	9
56	R:R:F62	R:R:M65	4.98	No	No	0	7	6
57	R:R:L63	R:R:M97	11.31	No	No	0	7	6
58	R:R:L64	R:R:L68	4.15	No	No	0	7	8
59	R:R:L64	R:R:N98	19.22	No	No	0	7	8
60	R:R:L64	R:R:S271	3	No	No	0	7	9
61	R:R:C67	R:R:T94	6.76	No	No	0	6	4
62	R:R:D73	R:R:F70	5.97	No	No	0	3	6
63	R:R:F70	R:R:F83	8.57	No	No	0	6	7
64	R:R:R71	R:R:Y74	6.17	No	Yes	1	6	5
65	R:R:R71	R:R:Y75	15.43	No	Yes	1	6	5
66	R:R:L95	R:R:R71	3.64	No	No	0	6	6
67	R:R:D73	R:R:L76	4.07	No	No	0	3	3
68	R:R:Y74	R:R:Y75	9.93	Yes	Yes	1	5	5
69	R:R:R79	R:R:Y74	13.38	Yes	Yes	1	5	5
70	R:R:W81	R:R:Y74	4.82	Yes	Yes	1	8	5
71	R:R:R79	R:R:Y75	3.09	Yes	Yes	1	5	5
72	R:R:A162	R:R:R79	4.15	No	Yes	0	3	5
73	R:R:H80	R:R:V163	4.15	No	No	0	5	5
74	R:R:F83	R:R:W81	6.01	No	Yes	0	7	8
75	R:R:C88	R:R:W81	7.84	No	Yes	1	9	8
76	R:R:L156	R:R:W81	3.42	No	Yes	0	5	8
77	R:R:V163	R:R:W81	11.03	No	Yes	0	5	8
78	R:R:C165	R:R:W81	14.37	No	Yes	1	9	8
79	R:R:D85	R:R:I86	7	No	No	0	3	3
80	R:R:D85	R:R:N154	12.12	No	No	0	3	4
81	R:R:D85	R:R:L156	6.79	No	No	0	3	5
82	R:R:I86	R:R:P87	6.77	No	No	0	3	6
83	R:R:I86	R:R:R89	13.78	No	No	0	3	6
84	R:R:C88	R:R:L92	3.17	No	No	1	9	6
85	R:R:C165	R:R:C88	7.28	No	No	1	9	9
86	R:R:L151	R:R:R89	3.64	No	No	0	5	6
87	R:R:N154	R:R:R89	3.62	No	No	0	4	6
88	R:R:G91	R:R:V90	3.68	No	No	0	6	5
89	R:R:H155	R:R:L92	9	No	No	1	4	6
90	R:R:L92	R:R:S167	3	No	No	1	6	4
91	R:R:F93	R:R:I144	3.77	No	No	0	5	4
92	R:R:F93	R:R:T147	6.49	No	No	0	5	6
93	R:R:F93	R:R:L151	20.7	No	No	0	5	5
94	R:R:L95	R:R:Y268	4.69	No	No	0	6	7
95	R:R:M97	R:R:W140	9.31	No	No	0	6	9
96	R:R:F181	R:R:R99	8.55	Yes	No	0	5	8
97	R:R:R99	R:R:T267	3.88	No	Yes	0	8	8
98	R:R:I103	R:R:S102	3.1	Yes	No	0	8	9
99	R:R:I103	R:R:P188	3.39	Yes	No	0	8	9
100	R:R:F229	R:R:I103	3.77	No	Yes	0	9	8
101	R:R:I103	R:R:Y233	10.88	Yes	Yes	0	8	9
102	R:R:F105	R:R:V136	3.93	Yes	No	5	7	7
103	R:R:F105	R:R:W140	14.03	Yes	No	0	7	9
104	R:R:L106	R:R:Y278	3.52	No	Yes	0	8	9
105	R:R:P188	R:R:T107	3.5	No	No	0	9	7
106	R:R:I191	R:R:T107	3.04	No	No	0	6	7
107	R:R:I192	R:R:T107	3.04	No	No	0	8	7
108	R:R:R113	R:R:V109	3.92	No	No	0	9	9
109	R:R:D112	R:R:K116	4.15	No	No	4	8	8
110	R:R:R113	R:R:Y278	6.17	No	Yes	0	9	9
111	R:R:F115	R:R:Y114	6.19	No	Yes	0	5	9
112	R:R:V118	R:R:Y114	11.36	Yes	Yes	3	7	9
113	R:R:H119	R:R:Y114	4.36	No	Yes	3	7	9
114	R:R:C195	R:R:Y114	6.72	No	Yes	0	8	9
115	R:R:K198	R:R:Y114	5.97	Yes	Yes	3	4	9
116	R:R:F115	R:R:V124	3.93	No	No	0	5	5
117	R:R:I199	R:R:V117	6.14	No	No	0	8	8
118	R:R:H119	R:R:V118	6.92	No	Yes	3	7	7
119	R:R:K198	R:R:V118	3.04	Yes	Yes	3	4	7
120	R:R:S202	R:R:V118	3.23	No	Yes	0	5	7
121	R:R:H122	R:R:V124	9.69	No	No	0	4	5
122	R:R:N125	R:R:T126	4.39	No	No	0	3	4
123	R:R:I127	R:R:V131	9.22	No	No	0	7	4
124	R:R:S128	R:R:V131	3.23	No	No	0	6	4
125	R:R:V143	R:R:W140	3.68	No	No	0	7	9
126	R:R:L150	R:R:Y149	8.21	No	No	0	5	7
127	R:R:H155	R:R:L150	3.86	No	No	0	4	5
128	R:R:H155	R:R:S167	15.34	No	No	1	4	4
129	R:R:V158	R:R:V163	3.21	No	No	0	1	5
130	R:R:E166	R:R:F168	3.5	No	Yes	2	4	4
131	R:R:E166	R:R:M170	8.12	No	Yes	2	4	3
132	R:R:E166	R:R:H261	13.54	No	No	2	4	5
133	R:R:F168	R:R:M170	6.22	Yes	Yes	2	4	3
134	R:R:F168	R:R:F181	6.43	Yes	Yes	2	4	5
135	R:R:F168	R:R:R240	10.69	Yes	Yes	2	4	5
136	R:R:A173	R:R:I169	6.5	No	No	2	3	4
137	R:R:H177	R:R:I169	25.19	Yes	No	2	5	4
138	R:R:I169	R:R:R240	7.52	No	Yes	2	4	5
139	R:R:L260	R:R:M170	7.07	No	Yes	2	4	3
140	R:R:H261	R:R:M170	3.94	No	Yes	2	5	3
141	R:R:A173	R:R:H177	5.85	No	Yes	2	3	5
142	R:R:H177	R:R:R240	10.16	Yes	Yes	2	5	5
143	R:R:E184	R:R:M180	5.41	No	No	0	5	4
144	R:R:F181	R:R:S236	3.96	Yes	No	2	5	6
145	R:R:F181	R:R:V237	6.55	Yes	Yes	2	5	8
146	R:R:F181	R:R:R240	4.28	Yes	Yes	2	5	5
147	R:R:F186	R:R:Q182	14.05	No	No	0	5	5
148	R:R:Q182	R:R:V237	4.3	No	Yes	0	5	8
149	R:R:F185	R:R:F186	8.57	No	No	0	8	5
150	R:R:F185	R:R:Y233	5.16	No	Yes	0	8	9
151	R:R:F185	R:R:V237	19.66	No	Yes	0	8	8
152	R:R:M187	R:R:P188	3.35	No	No	0	5	9
153	R:R:F229	R:R:L189	4.87	No	No	0	9	6
154	R:R:I230	R:R:L189	8.56	No	No	0	6	6
155	R:R:F194	R:R:K198	4.96	No	Yes	0	5	4
156	R:R:I222	R:R:S196	3.1	Yes	No	0	7	8
157	R:R:F197	R:R:K198	4.96	No	Yes	0	1	4
158	R:R:T219	R:R:V200	6.35	No	No	0	6	5
159	R:R:R205	R:R:W201	9	No	No	0	4	3
160	R:R:L203	R:R:M215	9.9	No	No	0	8	7
161	R:R:L209	R:R:R206	3.64	No	No	0	2	5
162	R:R:L209	R:R:Q212	3.99	No	No	0	2	3
163	R:R:L209	R:R:M215	5.65	No	No	0	2	7
164	R:R:K216	R:R:R220	3.71	No	No	0	4	5
165	R:R:F221	R:R:K217	4.96	No	No	0	8	7
166	R:R:F221	R:R:S281	13.21	No	No	0	8	7
167	R:R:V225	R:R:Y278	10.09	No	Yes	0	8	9
168	R:R:C232	R:R:M269	3.24	No	Yes	0	9	4
169	R:R:C232	R:R:N270	4.72	No	No	0	9	9
170	R:R:T267	R:R:Y233	4.99	Yes	Yes	0	8	9
171	R:R:N270	R:R:Y233	6.98	No	Yes	0	9	9
172	R:R:L234	R:R:P235	3.28	No	No	0	5	9
173	R:R:L234	R:R:S238	3	No	No	0	5	6
174	R:R:P235	R:R:T263	5.25	No	No	0	9	7
175	R:R:S236	R:R:V237	3.23	No	Yes	2	6	8
176	R:R:S236	R:R:T267	3.2	No	Yes	0	6	8
177	R:R:F243	R:R:R240	8.55	No	Yes	0	4	5
178	R:R:L244	R:R:R240	7.29	No	Yes	0	5	5
179	R:R:T246	R:R:Y242	4.99	No	No	0	3	4
180	R:R:F243	R:R:V247	3.93	No	No	0	4	3
181	R:R:S249	R:R:T246	3.2	No	No	0	1	3
182	R:R:S250	R:R:T246	3.2	No	No	0	2	3
183	R:R:P248	R:R:V247	3.53	No	No	0	1	3
184	R:R:S250	R:R:V247	3.23	No	No	0	2	3
185	R:R:D253	R:R:S250	4.42	Yes	No	0	2	2
186	R:R:D253	R:R:V256	7.3	Yes	No	0	2	3
187	R:R:H261	R:R:L260	5.14	No	No	2	5	4
188	R:R:L264	R:R:T267	8.84	No	Yes	0	6	8
189	R:R:L264	R:R:Y268	14.07	No	No	0	6	7
190	R:R:F266	R:R:S265	5.28	No	No	0	7	5
191	R:R:F266	R:R:M269	3.73	No	Yes	0	7	4
192	R:R:M269	R:R:M272	4.33	Yes	No	0	4	8
193	R:R:L273	R:R:M269	4.24	No	Yes	0	7	4
194	R:R:D274	R:R:P275	9.66	Yes	No	0	9	9
195	R:R:D274	R:R:Y278	8.05	Yes	Yes	0	9	9
196	R:R:F280	R:R:L276	6.09	No	No	0	7	6
197	R:R:V277	R:R:Y278	3.79	No	Yes	0	8	9
198	R:R:S282	R:R:S284	4.89	No	No	0	8	6
199	R:R:L31	R:R:V27	2.98	No	No	0	4	6
200	R:R:L139	R:R:V104	2.98	No	No	0	7	6
201	R:R:L273	R:R:V228	2.98	No	No	0	7	7
202	R:R:L63	R:R:T94	2.95	No	No	0	7	4
203	R:R:I199	R:R:I222	2.94	No	Yes	0	8	7
204	R:R:F266	R:R:P235	2.89	No	No	0	7	9
205	R:R:I135	R:R:L139	2.85	No	No	0	6	7
206	R:R:K116	R:R:N125	2.8	No	No	0	8	3
207	R:R:A60	R:R:F105	2.77	No	Yes	0	8	7
208	R:R:A132	R:R:Y53	2.67	No	Yes	0	8	7
209	R:R:Q207	R:R:Q208	2.56	No	No	0	4	3
210	R:R:S282	R:R:Y279	2.54	No	No	0	8	7
211	R:R:D178	R:R:H177	2.52	No	Yes	0	4	5
212	R:R:F26	R:R:I23	2.51	No	No	0	7	5
213	R:R:I222	R:R:R113	2.51	Yes	No	0	7	9
214	R:R:F181	R:R:M180	2.49	Yes	No	0	5	4
215	R:R:F55	R:R:L37	2.44	Yes	No	0	6	8
216	R:R:I199	R:R:Y114	2.42	No	Yes	0	8	9
217	R:R:Q212	R:R:R214	2.34	No	No	0	3	4
218	R:R:F197	R:R:W201	2	No	No	0	1	3
219	R:R:C38	R:R:G39	1.96	No	No	0	4	8
220	R:R:W176	R:R:Y149	1.93	No	No	0	5	7
221	R:R:A36	R:R:P275	1.87	No	No	0	8	9
222	R:R:G101	R:R:V104	1.84	No	No	0	7	6
223	R:R:G101	R:R:V143	1.84	No	No	0	7	7
224	R:R:G91	R:R:T94	1.82	No	No	0	6	4
225	R:R:P49	R:R:S50	1.78	No	No	0	7	7
226	R:R:P283	R:R:S282	1.78	No	No	0	5	8
227	R:R:G258	R:R:I14	1.76	No	No	0	1	4
228	R:R:G175	R:R:I179	1.76	No	No	0	3	4
229	R:R:G32	R:R:L31	1.71	No	No	0	7	4
230	R:R:G146	R:R:L145	1.71	No	No	0	4	3
231	R:R:G190	R:R:L189	1.71	No	No	0	3	6
232	R:R:A100	R:R:V143	1.7	No	No	0	6	7
233	R:R:G175	R:R:N174	1.7	No	No	0	3	3
234	R:R:I127	R:R:P49	1.69	No	No	0	7	7
235	R:R:A96	R:R:T147	1.68	No	No	0	5	6
236	R:R:A123	R:R:T126	1.68	No	No	0	5	4
237	R:R:A162	R:R:T161	1.68	No	No	0	3	5
238	R:R:A239	R:R:T263	1.68	No	No	0	4	7
239	R:R:C7	R:R:I9	1.64	No	No	0	6	4
240	R:R:L21	R:R:P20	1.64	No	No	0	4	4
241	R:R:L68	R:R:P69	1.64	No	No	0	8	9
242	R:R:A110	R:R:I192	1.62	No	No	0	9	8
243	R:R:S164	R:R:V158	1.62	No	No	0	4	1
244	R:R:A226	R:R:I192	1.62	No	No	0	7	8
245	R:R:S281	R:R:V277	1.62	No	No	0	7	8
246	R:R:D253	R:R:P254	1.61	Yes	No	0	2	2
247	R:R:T13	R:R:V17	1.59	No	No	0	3	5
248	R:R:T231	R:R:V228	1.59	No	No	0	6	7
249	R:R:A226	R:R:L193	1.58	No	No	0	7	4
250	R:R:I14	R:R:S15	1.55	No	No	0	4	5
251	R:R:I262	R:R:S265	1.55	No	No	0	5	5
252	R:R:I222	R:R:V200	1.54	Yes	No	0	7	5
253	R:R:A251	R:R:D253	1.54	No	Yes	0	2	2
254	R:R:H119	R:R:P120	1.53	No	No	0	7	7
255	R:R:H121	R:R:P120	1.53	No	No	0	6	7
256	R:R:F83	R:R:G84	1.51	No	No	0	7	8
257	R:R:K45	R:R:T46	1.5	No	No	0	6	6
258	R:R:K48	R:R:T51	1.5	No	No	0	7	8
259	R:R:K216	R:R:T219	1.5	No	No	0	4	6
260	R:R:L151	R:R:V148	1.49	No	No	0	5	3
261	R:R:L152	R:R:V148	1.49	No	No	0	3	3
262	R:R:I227	R:R:M223	1.46	No	No	0	4	5
263	R:R:I66	R:R:L63	1.43	No	No	0	5	7
264	R:R:L183	R:R:M187	1.41	No	No	0	4	5
265	R:R:D178	R:R:I179	1.4	No	No	0	4	4
266	R:R:A82	R:R:R77	1.38	No	No	0	3	4
267	R:R:L142	R:R:L145	1.38	No	No	0	4	3
268	R:R:R130	R:R:S128	1.32	No	No	0	4	6
269	R:R:F221	R:R:V224	1.31	No	No	0	8	6
270	R:R:T129	R:R:W47	1.21	No	No	0	3	6
271	R:R:L76	R:R:R77	1.21	No	No	0	3	4
272	R:R:K45	R:R:W47	1.16	No	No	0	6	6
273	R:R:L241	R:R:W245	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R8	5	4	0	2
2	R:R:M18	5.15	4	1	5
3	R:R:L22	6.065	4	1	7
4	R:R:Y53	6.78	4	0	7
5	R:R:F55	6.11	4	0	6
6	R:R:N56	6.8825	4	5	9
7	R:R:Y74	8.575	4	1	5
8	R:R:Y75	8.532	5	1	5
9	R:R:R79	6.61	4	1	5
10	R:R:W81	7.915	6	1	8
11	R:R:I103	5.285	4	0	8
12	R:R:F105	7.298	5	5	7
13	R:R:Y114	6.17	6	3	9
14	R:R:V118	6.1375	4	3	7
15	R:R:F168	6.71	4	2	4
16	R:R:M170	6.3375	4	2	3
17	R:R:H177	10.93	4	2	5
18	R:R:F181	5.37667	6	2	5
19	R:R:K198	4.7325	4	3	4
20	R:R:I222	2.5225	4	0	7
21	R:R:Y233	7.0025	4	0	9
22	R:R:V237	8.435	4	2	8
23	R:R:R240	8.08167	6	2	5
24	R:R:D253	3.7175	4	0	2
25	R:R:T267	5.2275	4	0	8
26	R:R:M269	3.885	4	0	4
27	R:R:D274	6.7825	4	0	9
28	R:R:Y278	6.324	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T13	R:R:V17	11.3509	1.59	No	No	0	3	5
2	R:R:I262	R:R:V17	12.9308	3.07	No	No	0	5	5
3	R:R:I262	R:R:S265	14.5001	1.55	No	No	0	5	5
4	R:R:F266	R:R:S265	16.0587	5.28	No	No	0	7	5
5	R:R:F266	R:R:M269	25.1882	3.73	No	Yes	0	7	4
6	R:R:C232	R:R:M269	35.3568	3.24	No	Yes	0	9	4
7	R:R:C232	R:R:N270	36.767	4.72	No	No	0	9	9
8	R:R:N270	R:R:Y233	38.1667	6.98	No	Yes	0	9	9
9	R:R:T267	R:R:Y233	53.3772	4.99	Yes	Yes	0	8	9
10	R:R:L264	R:R:T267	99.0192	8.84	No	Yes	0	6	8
11	R:R:L264	R:R:Y268	99.3638	14.07	No	No	0	6	7
12	R:R:L95	R:R:Y268	99.6978	4.69	No	No	0	6	7
13	R:R:L95	R:R:R71	100	3.64	No	No	0	6	6
14	R:R:R71	R:R:Y74	28.9948	6.17	No	Yes	1	6	5
15	R:R:W81	R:R:Y74	51.3731	4.82	Yes	Yes	1	8	5
16	R:R:V163	R:R:W81	12.7346	11.03	No	Yes	0	5	8
17	R:R:Y74	R:R:Y75	25.1776	9.93	Yes	Yes	1	5	5
18	R:R:L22	R:R:Y75	87.9758	7.03	Yes	Yes	1	7	5
19	R:R:L22	R:R:L68	93.866	4.15	Yes	No	0	7	8
20	R:R:L64	R:R:L68	93.0707	4.15	No	No	0	7	8
21	R:R:L64	R:R:S271	92.2331	3	No	No	0	7	9
22	R:R:D61	R:R:S271	91.7983	5.89	No	No	0	9	9
23	R:R:D274	R:R:D61	88.4689	3.99	Yes	No	0	9	9
24	R:R:D274	R:R:L57	64.6856	5.43	Yes	No	0	9	9
25	R:R:F105	R:R:L57	72.092	6.09	Yes	No	0	7	9
26	R:R:F105	R:R:N56	52.4494	9.67	Yes	Yes	5	7	9
27	R:R:F55	R:R:N56	22.9721	6.04	Yes	Yes	0	6	9
28	R:R:F55	R:R:L37	17.1297	2.44	Yes	No	0	6	8
29	R:R:F62	R:R:L37	14.235	4.87	No	No	0	7	8
30	R:R:F62	R:R:M65	12.7187	4.98	No	No	0	7	6
31	R:R:N56	R:R:V52	31.6668	4.43	Yes	No	0	9	7
32	R:R:V52	R:R:Y53	30.2513	7.57	No	Yes	0	7	7
33	R:R:D112	R:R:Y53	25.9463	8.05	No	Yes	0	8	7
34	R:R:D112	R:R:S50	18.418	8.83	No	No	4	8	7
35	R:R:P49	R:R:S50	17.1615	1.78	No	No	0	7	7
36	R:R:L106	R:R:L57	10.4496	4.15	No	No	0	8	9
37	R:R:D274	R:R:Y278	41.634	8.05	Yes	Yes	0	9	9
38	R:R:L106	R:R:Y278	10.2905	3.52	No	Yes	0	8	9
39	R:R:F105	R:R:W140	21.7951	14.03	Yes	No	0	7	9
40	R:R:M97	R:R:W140	11.1441	9.31	No	No	0	6	9
41	R:R:L156	R:R:W81	28.2632	3.42	No	Yes	0	5	8
42	R:R:D85	R:R:L156	27.1392	6.79	No	No	0	3	5
43	R:R:D85	R:R:I86	13.6306	7	No	No	0	3	3
44	R:R:D85	R:R:N154	12.2681	12.12	No	No	0	3	4
45	R:R:I86	R:R:R89	10.9904	13.78	No	No	0	3	6
46	R:R:N154	R:R:R89	10.9479	3.62	No	No	0	4	6
47	R:R:L151	R:R:R89	19.2185	3.64	No	No	0	5	6
48	R:R:F93	R:R:L151	11.0434	20.7	No	No	0	5	5
49	R:R:R99	R:R:T267	35.1712	3.88	No	Yes	0	8	8
50	R:R:F181	R:R:R99	34.201	8.55	Yes	No	0	5	8
51	R:R:S236	R:R:T267	37.0904	3.2	No	Yes	0	6	8
52	R:R:F181	R:R:S236	34.2488	3.96	Yes	No	2	5	6
53	R:R:I103	R:R:Y233	23.6931	10.88	Yes	Yes	0	8	9
54	R:R:I103	R:R:P188	14.5001	3.39	Yes	No	0	8	9
55	R:R:R113	R:R:Y278	39.9852	6.17	No	Yes	0	9	9
56	R:R:I222	R:R:R113	37.1594	2.51	Yes	No	0	7	9
57	R:R:I199	R:R:I222	28.1518	2.94	No	Yes	0	8	7
58	R:R:I199	R:R:Y114	25.1246	2.42	No	Yes	0	8	9
59	R:R:F168	R:R:F181	14.9878	6.43	Yes	Yes	2	4	5
60	R:R:F181	R:R:R240	53.5044	4.28	Yes	Yes	2	5	5
61	R:R:H177	R:R:R240	15.9368	10.16	Yes	Yes	2	5	5
62	R:R:F243	R:R:R240	29.0955	8.55	No	Yes	0	4	5
63	R:R:F243	R:R:V247	26.503	3.93	No	No	0	4	3
64	R:R:S250	R:R:V247	21.2862	3.23	No	No	0	2	3
65	R:R:D253	R:R:S250	10.7253	4.42	Yes	No	0	2	2
66	R:R:D178	R:R:H177	10.7041	2.52	No	Yes	0	4	5
67	R:R:R71	R:R:Y75	71.3498	15.43	No	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9J8Z_nogp

PDB Summary
PDB	9J8Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	259
Number of Links	273
Number of Hubs	28
Number of Links mediated by Hubs	102
Number of Communities	5
Number of Nodes involved in Communities	34
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	39527
Length Of Smallest Path	3
Average Path Length	16.0239
Length of Longest Path	39
Minimum Path Strength	1.185
Average Path Strength	5.90388
Maximum Path Strength	14.115
Minimum Path Correlation	0.7
Average Path Correlation	0.926114
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.3609
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.5953
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC0
Sequence	>9J8Z_nogp_Chain_R C C R I E G D T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H M K T W K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R R R H W A F G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H P H H A V N T I S T R V A A G I V C T L W A L V I L G T V Y L L L E N H L C V Q E T A V S C E S F I M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q Q L A R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T V P S S A C D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZD	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	3.16	2025-04-02	To be published
	9IZD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	CHBA	-		3.16	2025-04-02	To be published
	9J8Z	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	3.36	2025-04-02	To be published
	9J8Z (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	-	-		3.36	2025-04-02	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9J8Z_nogp.zip

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