psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R71	21.46	Yes	Yes	1	0	6
2	L:L:?1	R:R:Y75	5.75	Yes	Yes	1	0	5
3	L:L:?1	R:R:L95	17.66	Yes	No	1	0	6
4	L:L:?1	R:R:R99	5.96	Yes	No	0	0	8
5	L:L:?1	R:R:E166	7.8	Yes	Yes	1	0	4
6	L:L:?1	R:R:H261	7.57	Yes	Yes	1	0	5
7	L:L:?1	R:R:Y268	13.81	Yes	No	1	0	7
8	R:R:C157	R:R:C6	7.28	No	No	0	3	6
9	R:R:C6	R:R:Q159	7.63	No	No	0	6	3
10	R:R:C7	R:R:E171	7.6	No	No	0	6	1
11	R:R:C252	R:R:C7	7.28	No	No	0	7	6
12	R:R:C252	R:R:I9	4.91	No	No	0	7	4
13	R:R:H257	R:R:I9	9.28	No	No	0	4	4
14	R:R:D12	R:R:T13	7.23	No	No	0	4	3
15	R:R:T13	R:R:V17	4.76	No	No	0	3	5
16	R:R:G258	R:R:I14	3.53	No	No	0	1	4
17	R:R:R78	R:R:S15	6.59	No	No	0	3	5
18	R:R:M18	R:R:P19	5.03	Yes	No	0	5	6
19	R:R:L22	R:R:M18	9.9	No	Yes	0	7	5
20	R:R:M18	R:R:Y75	10.78	Yes	Yes	1	5	5
21	R:R:I262	R:R:M18	4.37	No	Yes	1	5	5
22	R:R:M18	R:R:S265	6.13	Yes	Yes	1	5	5
23	R:R:P19	R:R:P20	5.84	No	No	0	6	4
24	R:R:F26	R:R:L68	6.09	No	No	2	7	8
25	R:R:F26	R:R:P69	14.45	No	No	2	7	9
26	R:R:L28	R:R:M272	11.31	No	No	0	5	8
27	R:R:G29	R:R:N33	5.09	No	Yes	2	8	9
28	R:R:G29	R:R:M65	5.24	No	Yes	2	8	6
29	R:R:G32	R:R:P275	4.06	Yes	No	0	7	9
30	R:R:D61	R:R:N33	10.77	No	Yes	0	9	9
31	R:R:M65	R:R:N33	4.21	Yes	Yes	2	6	9
32	R:R:N33	R:R:P275	6.52	Yes	No	0	9	9
33	R:R:A36	R:R:Y279	5.34	No	Yes	0	8	7
34	R:R:F55	R:R:L37	6.09	Yes	No	0	6	8
35	R:R:C38	R:R:F42	12.57	No	No	0	4	4
36	R:R:G39	R:R:Y279	4.35	No	Yes	0	8	7
37	R:R:F40	R:R:M44	3.73	Yes	No	4	7	6
38	R:R:F40	R:R:L54	3.65	Yes	No	0	7	8
39	R:R:F40	R:R:F55	7.5	Yes	Yes	0	7	6
40	R:R:F40	R:R:Y279	14.44	Yes	Yes	4	7	7
41	R:R:M44	R:R:Y279	4.79	No	Yes	4	6	7
42	R:R:M44	R:R:S284	4.6	No	No	0	6	6
43	R:R:K45	R:R:T46	7.51	No	No	0	6	6
44	R:R:F55	R:R:W47	12.03	Yes	No	0	6	6
45	R:R:K48	R:R:P49	15.06	No	No	0	7	7
46	R:R:D112	R:R:S50	8.83	No	No	0	8	7
47	R:R:N56	R:R:V52	4.43	Yes	No	0	9	7
48	R:R:A132	R:R:V52	3.39	No	No	0	8	7
49	R:R:V108	R:R:Y53	8.83	No	No	0	6	7
50	R:R:D112	R:R:Y53	6.9	No	No	0	8	7
51	R:R:A132	R:R:Y53	4	No	No	0	8	7
52	R:R:L54	R:R:Y278	4.69	No	Yes	0	8	9
53	R:R:F55	R:R:N56	3.62	Yes	Yes	0	6	9
54	R:R:F55	R:R:V59	7.87	Yes	No	0	6	5
55	R:R:F105	R:R:N56	8.46	Yes	Yes	5	7	9
56	R:R:N56	R:R:V136	11.82	Yes	No	5	9	7
57	R:R:F105	R:R:L57	4.87	Yes	No	0	7	9
58	R:R:L106	R:R:L57	5.54	No	No	0	8	9
59	R:R:D61	R:R:S271	5.89	No	No	0	9	9
60	R:R:D274	R:R:D61	3.99	No	No	0	9	9
61	R:R:F62	R:R:I66	3.77	No	No	0	7	5
62	R:R:L63	R:R:N98	6.87	No	Yes	0	7	8
63	R:R:L64	R:R:N98	6.87	No	Yes	0	7	8
64	R:R:L68	R:R:M65	7.07	No	Yes	2	8	6
65	R:R:C67	R:R:T94	5.07	No	No	1	6	4
66	R:R:C67	R:R:L95	4.76	No	No	1	6	6
67	R:R:C67	R:R:N98	4.72	No	Yes	1	6	8
68	R:R:L68	R:R:P69	6.57	No	No	2	8	9
69	R:R:R71	R:R:Y74	5.14	Yes	Yes	1	6	5
70	R:R:R71	R:R:Y75	13.38	Yes	Yes	1	6	5
71	R:R:E166	R:R:R71	4.65	Yes	Yes	1	4	6
72	R:R:D73	R:R:R77	3.57	No	No	0	3	4
73	R:R:Y74	R:R:Y75	3.97	Yes	Yes	1	5	5
74	R:R:R79	R:R:Y74	10.29	No	Yes	0	5	5
75	R:R:W81	R:R:Y74	3.86	Yes	Yes	0	8	5
76	R:R:S164	R:R:Y74	5.09	No	Yes	0	4	5
77	R:R:E166	R:R:Y74	16.83	Yes	Yes	1	4	5
78	R:R:H261	R:R:Y75	10.89	Yes	Yes	1	5	5
79	R:R:L76	R:R:R77	4.86	No	No	0	3	4
80	R:R:R77	R:R:W81	4	No	Yes	0	4	8
81	R:R:H80	R:R:V163	8.3	No	No	0	5	5
82	R:R:F83	R:R:W81	9.02	Yes	Yes	0	7	8
83	R:R:C88	R:R:W81	5.22	No	Yes	0	9	8
84	R:R:F83	R:R:P87	10.11	Yes	No	0	7	6
85	R:R:D85	R:R:I86	5.6	No	No	0	3	3
86	R:R:D85	R:R:R89	5.96	No	No	0	3	6
87	R:R:I86	R:R:P87	3.39	No	No	0	3	6
88	R:R:C165	R:R:C88	7.28	No	No	6	9	9
89	R:R:N154	R:R:R89	8.44	No	No	0	4	6
90	R:R:F93	R:R:M97	4.98	Yes	Yes	1	5	6
91	R:R:F93	R:R:T147	5.19	Yes	No	1	5	6
92	R:R:F93	R:R:L150	3.65	Yes	No	0	5	5
93	R:R:F93	R:R:L151	18.27	Yes	No	0	5	5
94	R:R:N98	R:R:T94	4.39	Yes	No	1	8	4
95	R:R:L95	R:R:Y268	5.86	No	No	1	6	7
96	R:R:M97	R:R:N98	4.21	Yes	Yes	1	6	8
97	R:R:M97	R:R:W140	3.49	Yes	Yes	0	6	9
98	R:R:M97	R:R:T147	6.02	Yes	No	1	6	6
99	R:R:E184	R:R:R99	5.82	No	No	0	5	8
100	R:R:E184	R:R:I103	5.47	No	Yes	0	5	8
101	R:R:I103	R:R:P188	3.39	Yes	No	0	8	9
102	R:R:I103	R:R:Y233	8.46	Yes	Yes	0	8	9
103	R:R:F105	R:R:V136	3.93	Yes	No	5	7	7
104	R:R:F105	R:R:W140	12.03	Yes	Yes	0	7	9
105	R:R:D274	R:R:L106	4.07	No	No	0	9	8
106	R:R:L106	R:R:Y278	4.69	No	Yes	0	8	9
107	R:R:P188	R:R:T107	5.25	No	No	0	9	7
108	R:R:R113	R:R:V109	5.23	No	No	0	9	9
109	R:R:A110	R:R:C195	3.61	No	Yes	0	9	8
110	R:R:D112	R:R:K116	11.06	No	No	0	8	8
111	R:R:F115	R:R:Y114	5.16	No	Yes	0	5	9
112	R:R:V118	R:R:Y114	10.09	No	Yes	7	7	9
113	R:R:H119	R:R:Y114	7.62	No	Yes	7	7	9
114	R:R:C195	R:R:Y114	4.03	Yes	Yes	0	8	9
115	R:R:K198	R:R:Y114	9.55	Yes	Yes	0	4	9
116	R:R:F115	R:R:V124	5.24	No	No	0	5	5
117	R:R:K116	R:R:N125	5.6	No	No	0	8	3
118	R:R:H119	R:R:V118	11.07	No	No	7	7	7
119	R:R:S202	R:R:V118	4.85	No	No	0	5	7
120	R:R:H121	R:R:P120	4.58	No	No	0	6	7
121	R:R:H122	R:R:V124	11.07	No	No	0	4	5
122	R:R:I127	R:R:V131	6.14	No	No	0	7	4
123	R:R:R130	R:R:S128	3.95	No	No	0	4	6
124	R:R:V143	R:R:W140	3.68	No	Yes	0	7	9
125	R:R:L150	R:R:Y149	8.21	No	Yes	0	5	7
126	R:R:W176	R:R:Y149	14.47	No	Yes	8	5	7
127	R:R:H177	R:R:Y149	13.07	Yes	Yes	0	5	7
128	R:R:M180	R:R:Y149	3.59	No	Yes	8	4	7
129	R:R:C165	R:R:L156	6.35	No	No	0	9	5
130	R:R:C157	R:R:S164	3.44	No	No	0	3	4
131	R:R:E160	R:R:T161	9.88	No	No	0	2	5
132	R:R:E166	R:R:H261	9.85	Yes	Yes	1	4	5
133	R:R:H177	R:R:S167	5.58	Yes	No	0	5	4
134	R:R:F168	R:R:H177	11.31	Yes	Yes	0	4	5
135	R:R:F168	R:R:F181	12.86	Yes	Yes	3	4	5
136	R:R:F168	R:R:R240	16.03	Yes	Yes	3	4	5
137	R:R:F168	R:R:L264	3.65	Yes	No	0	4	6
138	R:R:F243	R:R:M170	9.95	Yes	No	0	4	3
139	R:R:H257	R:R:M170	10.51	No	No	0	4	3
140	R:R:A173	R:R:L244	4.73	No	Yes	0	3	5
141	R:R:G175	R:R:N174	5.09	No	No	0	3	3
142	R:R:H177	R:R:N174	6.38	Yes	No	0	5	3
143	R:R:M180	R:R:W176	9.31	No	No	8	4	5
144	R:R:D178	R:R:Q182	3.92	No	Yes	0	4	5
145	R:R:D178	R:R:R240	15.48	No	Yes	3	4	5
146	R:R:D178	R:R:L244	12.21	No	Yes	3	4	5
147	R:R:E184	R:R:F181	5.83	No	Yes	0	5	5
148	R:R:F181	R:R:S236	5.28	Yes	No	0	5	6
149	R:R:F181	R:R:R240	4.28	Yes	Yes	3	5	5
150	R:R:F186	R:R:Q182	3.51	No	Yes	0	5	5
151	R:R:Q182	R:R:V237	5.73	Yes	No	0	5	8
152	R:R:L241	R:R:Q182	3.99	No	Yes	0	5	5
153	R:R:F185	R:R:F186	5.36	Yes	No	0	8	5
154	R:R:F185	R:R:L189	7.31	Yes	Yes	0	8	6
155	R:R:F185	R:R:F229	5.36	Yes	No	0	8	9
156	R:R:F185	R:R:L234	3.65	Yes	No	0	8	5
157	R:R:F185	R:R:V237	9.18	Yes	No	0	8	8
158	R:R:M187	R:R:P188	8.39	No	No	0	5	9
159	R:R:L189	R:R:L193	5.54	Yes	No	0	6	4
160	R:R:I230	R:R:L189	7.14	No	Yes	0	6	6
161	R:R:F194	R:R:K198	12.41	No	Yes	0	5	4
162	R:R:K198	R:R:W201	3.48	Yes	No	0	4	3
163	R:R:T219	R:R:V200	6.35	No	No	0	6	5
164	R:R:S202	R:R:W201	6.18	No	No	0	5	3
165	R:R:R205	R:R:W201	10	No	No	0	4	3
166	R:R:R204	R:R:T219	10.35	No	No	0	4	6
167	R:R:L209	R:R:M215	4.24	Yes	No	0	2	7
168	R:R:Q212	R:R:R214	10.51	No	No	0	3	4
169	R:R:F221	R:R:K217	7.44	No	No	0	8	7
170	R:R:F221	R:R:S281	9.25	No	No	0	8	7
171	R:R:V225	R:R:Y278	11.36	No	Yes	0	8	9
172	R:R:F229	R:R:Y233	5.16	No	Yes	0	9	9
173	R:R:I230	R:R:L234	4.28	No	No	0	6	5
174	R:R:T267	R:R:Y233	8.74	No	Yes	0	8	9
175	R:R:N270	R:R:Y233	13.96	No	Yes	0	9	9
176	R:R:S236	R:R:T267	4.8	No	No	0	6	8
177	R:R:A239	R:R:T263	5.03	No	No	0	4	7
178	R:R:F243	R:R:R240	11.76	Yes	Yes	3	4	5
179	R:R:L244	R:R:R240	6.07	Yes	Yes	3	5	5
180	R:R:F243	R:R:L244	3.65	Yes	Yes	3	4	5
181	R:R:T246	R:R:W245	6.06	No	No	0	3	4
182	R:R:P248	R:R:V247	3.53	No	No	0	1	3
183	R:R:D253	R:R:P254	11.27	No	No	0	2	2
184	R:R:D253	R:R:V256	8.76	No	No	0	2	3
185	R:R:H257	R:R:H261	16.72	No	Yes	0	4	5
186	R:R:I262	R:R:S265	4.64	No	Yes	1	5	5
187	R:R:M269	R:R:M272	5.78	No	No	0	4	8
188	R:R:D274	R:R:N270	12.12	No	No	0	9	9
189	R:R:F280	R:R:L276	3.65	No	No	0	7	6
190	R:R:V277	R:R:Y278	5.05	No	Yes	0	8	9
191	R:R:P283	R:R:S282	3.56	No	No	0	5	8
192	R:R:S282	R:R:S284	4.89	No	No	0	8	6
193	R:R:E10	R:R:G11	3.27	No	No	0	4	4
194	R:R:S128	R:R:V131	3.23	No	No	0	6	4
195	R:R:F70	R:R:F83	3.22	No	Yes	0	6	7
196	R:R:A213	R:R:K216	3.21	No	No	0	3	4
197	R:R:S236	R:R:T263	3.2	No	No	0	6	7
198	R:R:C232	R:R:N270	3.15	No	No	0	9	9
199	R:R:I222	R:R:S196	3.1	No	No	0	7	8
200	R:R:I199	R:R:V117	3.07	No	No	0	8	8
201	R:R:I222	R:R:V200	3.07	No	No	0	7	5
202	R:R:I23	R:R:T72	3.04	No	No	0	5	7
203	R:R:M272	R:R:V24	3.04	No	No	0	8	5
204	R:R:I191	R:R:T107	3.04	No	No	0	6	7
205	R:R:I192	R:R:T107	3.04	No	No	0	8	7
206	R:R:G11	R:R:R79	3	No	No	0	4	5
207	R:R:L21	R:R:S265	3	No	Yes	0	4	5
208	R:R:L234	R:R:S238	3	No	No	0	5	6
209	R:R:L31	R:R:V27	2.98	No	No	0	4	6
210	R:R:L54	R:R:V109	2.98	No	No	0	8	9
211	R:R:L139	R:R:V104	2.98	No	No	0	7	6
212	R:R:C88	R:R:H155	2.95	No	No	6	9	4
213	R:R:C165	R:R:H155	2.95	No	No	6	9	4
214	R:R:I14	R:R:I262	2.94	No	No	0	4	5
215	R:R:I199	R:R:I222	2.94	No	No	0	8	7
216	R:R:A123	R:R:H122	2.93	No	No	0	5	4
217	R:R:I144	R:R:M97	2.92	No	Yes	0	4	6
218	R:R:I135	R:R:L139	2.85	No	No	0	6	7
219	R:R:L21	R:R:M269	2.83	No	No	0	4	4
220	R:R:L260	R:R:M170	2.83	No	No	0	4	3
221	R:R:G101	R:R:W140	2.81	No	Yes	0	7	9
222	R:R:C41	R:R:F42	2.79	No	No	0	4	4
223	R:R:A30	R:R:F26	2.77	No	No	0	5	7
224	R:R:A58	R:R:F40	2.77	No	Yes	0	8	7
225	R:R:A60	R:R:F105	2.77	No	Yes	0	8	7
226	R:R:A82	R:R:F83	2.77	No	Yes	0	3	7
227	R:R:E171	R:R:I169	2.73	No	No	0	1	4
228	L:L:?1	R:R:L92	2.72	Yes	No	0	0	6
229	R:R:F243	R:R:S250	2.64	Yes	No	0	4	2
230	R:R:F266	R:R:S265	2.64	No	Yes	0	7	5
231	R:R:F243	R:R:V256	2.62	Yes	No	0	4	3
232	R:R:F197	R:R:K198	2.48	No	Yes	0	1	4
233	R:R:E153	R:R:H155	2.46	No	No	0	4	4
234	R:R:F62	R:R:L37	2.44	No	No	0	7	8
235	R:R:T51	R:R:W47	2.43	No	No	0	8	6
236	R:R:L209	R:R:R206	2.43	Yes	No	0	2	5
237	R:R:I199	R:R:Y114	2.42	No	Yes	0	8	9
238	R:R:I179	R:R:W176	2.35	No	No	0	4	5
239	R:R:F42	R:R:H43	2.26	No	No	0	4	5
240	R:R:C38	R:R:G39	1.96	No	No	0	4	8
241	R:R:C137	R:R:G134	1.96	No	No	0	5	2
242	R:R:A132	R:R:P49	1.87	No	No	0	8	7
243	R:R:G32	R:R:V35	1.84	Yes	No	0	7	5
244	R:R:G91	R:R:V90	1.84	No	No	0	6	5
245	R:R:G101	R:R:V104	1.84	No	No	0	7	6
246	R:R:G91	R:R:T94	1.82	No	No	0	6	4
247	R:R:A111	R:R:C195	1.81	No	Yes	0	6	8
248	R:R:P19	R:R:T72	1.75	No	No	0	6	7
249	R:R:P69	R:R:T72	1.75	No	No	0	9	7
250	R:R:P235	R:R:T263	1.75	No	No	0	9	7
251	R:R:G32	R:R:L31	1.71	Yes	No	0	7	4
252	R:R:G34	R:R:L37	1.71	No	No	0	4	8
253	R:R:G146	R:R:L145	1.71	No	No	0	4	3
254	R:R:G190	R:R:L189	1.71	No	Yes	0	3	6
255	R:R:A226	R:R:S196	1.71	No	No	0	7	8
256	R:R:A100	R:R:V143	1.7	No	No	0	6	7
257	R:R:D12	R:R:G11	1.68	No	No	0	4	4
258	R:R:A96	R:R:T147	1.68	No	No	0	5	6
259	R:R:A123	R:R:T126	1.68	No	No	0	5	4
260	R:R:C195	R:R:I191	1.64	Yes	No	0	8	6
261	R:R:A25	R:R:M65	1.61	No	Yes	0	7	6
262	R:R:V224	R:R:V228	1.6	No	No	0	6	7
263	R:R:S250	R:R:T246	1.6	No	No	0	2	3
264	R:R:T129	R:R:V52	1.59	No	No	0	3	7
265	R:R:I103	R:R:S102	1.55	Yes	No	0	8	9
266	R:R:I127	R:R:V124	1.54	No	No	0	7	5
267	R:R:I135	R:R:V131	1.54	No	No	0	6	4
268	R:R:I144	R:R:V148	1.54	No	No	0	4	3
269	R:R:H119	R:R:P120	1.53	No	No	0	7	7
270	R:R:F280	R:R:G32	1.51	No	Yes	0	7	7
271	R:R:F83	R:R:G84	1.51	Yes	No	0	7	8
272	R:R:L203	R:R:V117	1.49	No	No	0	8	8
273	R:R:L152	R:R:V148	1.49	No	No	0	3	3
274	R:R:L273	R:R:V228	1.49	No	No	0	7	7
275	R:R:L273	R:R:V277	1.49	No	No	0	7	8
276	R:R:I227	R:R:I230	1.47	No	No	0	4	6
277	R:R:D253	R:R:S255	1.47	No	No	0	2	4
278	R:R:I179	R:R:L183	1.43	No	No	0	4	4
279	R:R:L203	R:R:L209	1.38	No	Yes	0	8	2
280	R:R:L209	R:R:Q212	1.33	Yes	No	0	2	3
281	R:R:R220	R:R:V224	1.31	No	No	0	5	6
282	R:R:Q207	R:R:Q208	1.28	No	No	0	4	3
283	R:R:T246	R:R:Y242	1.25	No	No	0	3	4
284	R:R:V163	R:R:W81	1.23	No	Yes	0	5	8
285	R:R:Q159	R:R:R8	1.17	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.3412	8	1	0
2	R:R:M18	7.242	5	1	5
3	R:R:G32	2.28	4	0	7
4	R:R:N33	6.6475	4	2	9
5	R:R:F40	6.418	5	4	7
6	R:R:F55	7.422	5	0	6
7	R:R:N56	7.0825	4	5	9
8	R:R:M65	4.5325	4	2	6
9	R:R:R71	11.1575	4	1	6
10	R:R:Y74	7.53	6	1	5
11	R:R:Y75	8.954	5	1	5
12	R:R:W81	4.666	5	0	8
13	R:R:F83	5.326	5	0	7
14	R:R:F93	8.0225	4	1	5
15	R:R:M97	4.324	5	1	6
16	R:R:N98	5.412	5	1	8
17	R:R:I103	4.7175	4	0	8
18	R:R:F105	6.412	5	5	7
19	R:R:Y114	6.47833	6	7	9
20	R:R:W140	5.5025	4	0	9
21	R:R:Y149	9.835	4	8	7
22	R:R:E166	9.7825	4	1	4
23	R:R:F168	10.9625	4	3	4
24	R:R:H177	9.085	4	0	5
25	R:R:F181	7.0625	4	3	5
26	R:R:Q182	4.2875	4	0	5
27	R:R:F185	6.172	5	0	8
28	R:R:L189	5.425	4	0	6
29	R:R:C195	2.7725	4	0	8
30	R:R:K198	6.98	4	0	4
31	R:R:L209	2.345	4	0	2
32	R:R:Y233	9.08	4	0	9
33	R:R:R240	10.724	5	3	5
34	R:R:F243	6.124	5	3	4
35	R:R:L244	6.665	4	3	5
36	R:R:H261	11.2575	4	1	5
37	R:R:S265	4.1025	4	1	5
38	R:R:Y278	6.4475	4	0	9
39	R:R:Y279	7.23	4	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R71	43.1416	21.46	Yes	Yes	1	0	6
2	R:R:R71	R:R:Y74	42.0503	5.14	Yes	Yes	1	6	5
3	R:R:S164	R:R:Y74	24.6854	5.09	No	Yes	0	4	5
4	R:R:C157	R:R:S164	19.7786	3.44	No	No	0	3	4
5	L:L:?1	R:R:Y75	64.6487	5.75	Yes	Yes	1	0	5
6	R:R:Y74	R:R:Y75	58.5471	3.97	Yes	Yes	1	5	5
7	L:L:?1	R:R:E166	43.3328	7.8	Yes	Yes	1	0	4
8	R:R:E166	R:R:Y74	50.1274	16.83	Yes	Yes	1	4	5
9	R:R:C157	R:R:C6	14.8558	7.28	No	No	0	3	6
10	R:R:H257	R:R:H261	29.8072	16.72	No	Yes	0	4	5
11	R:R:H257	R:R:I9	12.4184	9.28	No	No	0	4	4
12	R:R:R79	R:R:Y74	29.5762	10.29	No	Yes	0	5	5
13	R:R:G11	R:R:R79	24.6854	3	No	No	0	4	5
14	R:R:D12	R:R:G11	14.8558	1.68	No	No	0	4	4
15	R:R:M18	R:R:Y75	36.9285	10.78	Yes	Yes	1	5	5
16	R:R:M18	R:R:P19	17.9544	5.03	Yes	No	0	5	6
17	R:R:P19	R:R:T72	15.2302	1.75	No	No	0	6	7
18	R:R:P69	R:R:T72	13.5734	1.75	No	No	0	9	7
19	R:R:L68	R:R:P69	11.6457	6.57	No	No	2	8	9
20	R:R:M18	R:R:S265	14.8319	6.13	Yes	Yes	1	5	5
21	R:R:L21	R:R:S265	10.8252	3	No	Yes	0	4	5
22	R:R:L68	R:R:M65	14.8001	7.07	No	Yes	2	8	6
23	R:R:M65	R:R:N33	16.3295	4.21	Yes	Yes	2	6	9
24	L:L:?1	R:R:R99	100	5.96	Yes	No	0	0	8
25	R:R:E184	R:R:R99	99.7212	5.82	No	No	0	5	8
26	R:R:E184	R:R:I103	95.9216	5.47	No	Yes	0	5	8
27	R:R:I103	R:R:Y233	64.2026	8.46	Yes	Yes	0	8	9
28	R:R:N270	R:R:Y233	64.2743	13.96	No	Yes	0	9	9
29	R:R:D274	R:R:N270	61.9006	12.12	No	No	0	9	9
30	R:R:D274	R:R:D61	31.4163	3.99	No	No	0	9	9
31	R:R:D61	R:R:N33	27.306	10.77	No	Yes	0	9	9
32	R:R:N33	R:R:P275	16.3852	6.52	Yes	No	0	9	9
33	R:R:G32	R:R:P275	14.0911	4.06	Yes	No	0	7	9
34	L:L:?1	R:R:L95	70.5114	17.66	Yes	No	1	0	6
35	R:R:C67	R:R:L95	69.9379	4.76	No	No	1	6	6
36	R:R:C67	R:R:N98	63.8681	4.72	No	Yes	1	6	8
37	R:R:M97	R:R:N98	64.5611	4.21	Yes	Yes	1	6	8
38	R:R:M97	R:R:W140	71.1168	3.49	Yes	Yes	0	6	9
39	R:R:F105	R:R:W140	66.8632	12.03	Yes	Yes	0	7	9
40	R:R:F105	R:R:N56	61.4227	8.46	Yes	Yes	5	7	9
41	R:R:F55	R:R:N56	38.2348	3.62	Yes	Yes	0	6	9
42	R:R:F40	R:R:F55	25.4182	7.5	Yes	Yes	0	7	6
43	R:R:F40	R:R:Y279	17.9863	14.44	Yes	Yes	4	7	7
44	R:R:F55	R:R:L37	11.7253	6.09	Yes	No	0	6	8
45	R:R:G39	R:R:Y279	13.2547	4.35	No	Yes	0	8	7
46	R:R:C38	R:R:G39	10.6341	1.96	No	No	0	4	8
47	R:R:F40	R:R:M44	10.1083	3.73	Yes	No	4	7	6
48	R:R:D274	R:R:L106	57.1451	4.07	No	No	0	9	8
49	R:R:L106	R:R:Y278	41.4131	4.69	No	Yes	0	8	9
50	R:R:L54	R:R:Y278	25.5616	4.69	No	Yes	0	8	9
51	R:R:N56	R:R:V52	26.7883	4.43	Yes	No	0	9	7
52	R:R:A132	R:R:V52	21.9771	3.39	No	No	0	8	7
53	R:R:A132	R:R:Y53	14.6248	4	No	No	0	8	7
54	R:R:F105	R:R:L57	23.2754	4.87	Yes	No	0	7	9
55	R:R:W81	R:R:Y74	95.6349	3.86	Yes	Yes	0	8	5
56	R:R:R77	R:R:W81	14.8558	4	No	Yes	0	4	8
57	R:R:F83	R:R:W81	44.1533	9.02	Yes	Yes	0	7	8
58	R:R:F83	R:R:P87	24.6854	10.11	Yes	No	0	7	6
59	R:R:I86	R:R:P87	19.7786	3.39	No	No	0	3	6
60	R:R:D85	R:R:I86	14.8558	5.6	No	No	0	3	3
61	R:R:C88	R:R:W81	23.9366	5.22	No	Yes	0	9	8
62	R:R:F93	R:R:M97	17.0862	4.98	Yes	Yes	1	5	6
63	R:R:F93	R:R:L150	15.27	3.65	Yes	No	0	5	5
64	R:R:I103	R:R:P188	76.1431	3.39	Yes	No	0	8	9
65	R:R:P188	R:R:T107	72.2559	5.25	No	No	0	9	7
66	R:R:I191	R:R:T107	68.3368	3.04	No	No	0	6	7
67	R:R:C195	R:R:I191	66.3693	1.64	Yes	No	0	8	6
68	R:R:C195	R:R:Y114	60.658	4.03	Yes	Yes	0	8	9
69	R:R:F115	R:R:Y114	21.6345	5.16	No	Yes	0	5	9
70	R:R:K198	R:R:Y114	12.6016	9.55	Yes	Yes	0	4	9
71	R:R:F115	R:R:V124	20.1689	5.24	No	No	0	5	5
72	R:R:G101	R:R:W140	26.7246	2.81	No	Yes	0	7	9
73	R:R:G101	R:R:V104	24.8686	1.84	No	No	0	7	6
74	R:R:L139	R:R:V104	22.9887	2.98	No	No	0	7	6
75	R:R:I135	R:R:L139	21.1566	2.85	No	No	0	6	7
76	R:R:I135	R:R:V131	19.3405	1.54	No	No	0	6	4
77	R:R:I127	R:R:V131	15.4453	6.14	No	No	0	7	4
78	R:R:I127	R:R:V124	15.3258	1.54	No	No	0	7	5
79	R:R:E184	R:R:F181	43.4204	5.83	No	Yes	0	5	5
80	R:R:F168	R:R:F181	21.1327	12.86	Yes	Yes	3	4	5
81	R:R:F168	R:R:H177	27.1945	11.31	Yes	Yes	0	4	5
82	R:R:H177	R:R:Y149	20.6468	13.07	Yes	Yes	0	5	7
83	R:R:H257	R:R:M170	22.9568	10.51	No	No	0	4	3
84	R:R:F243	R:R:M170	23.5622	9.95	Yes	No	0	4	3
85	R:R:F181	R:R:R240	23.8888	4.28	Yes	Yes	3	5	5
86	R:R:D178	R:R:R240	18.2731	15.48	No	Yes	3	4	5
87	R:R:D178	R:R:Q182	22.2479	3.92	No	Yes	0	4	5
88	R:R:F181	R:R:S236	16.8074	5.28	Yes	No	0	5	6
89	R:R:F229	R:R:Y233	32.9775	5.16	No	Yes	0	9	9
90	R:R:F185	R:R:F229	30.8746	5.36	Yes	No	0	8	9
91	R:R:F185	R:R:L189	15.5727	7.31	Yes	Yes	0	8	6
92	R:R:F185	R:R:L234	12.4661	3.65	Yes	No	0	8	5
93	R:R:I199	R:R:Y114	34.252	2.42	No	Yes	0	8	9
94	R:R:I199	R:R:I222	14.9195	2.94	No	No	0	8	7
95	R:R:I199	R:R:V117	17.588	3.07	No	No	0	8	8
96	R:R:L203	R:R:V117	15.1346	1.49	No	No	0	8	8
97	R:R:L203	R:R:L209	12.6573	1.38	No	Yes	0	8	2
98	R:R:T267	R:R:Y233	14.9195	8.74	No	Yes	0	8	9
99	R:R:S236	R:R:T267	14.0991	4.8	No	No	0	6	8
100	R:R:F243	R:R:S250	11.5899	2.64	Yes	No	0	4	2
101	R:R:F243	R:R:V256	11.5899	2.62	Yes	No	0	4	3
102	R:R:V277	R:R:Y278	14.3699	5.05	No	Yes	0	8	9
103	R:R:L273	R:R:V277	11.5262	1.49	No	No	0	7	8
104	R:R:H261	R:R:Y75	14.123	10.89	Yes	Yes	1	5	5
105	R:R:F243	R:R:R240	24.6455	11.76	Yes	Yes	3	4	5
106	R:R:F40	R:R:L54	19.8821	3.65	Yes	No	0	7	8
107	R:R:L106	R:R:L57	22.8214	5.54	No	No	0	8	9
108	R:R:L150	R:R:Y149	14.3381	8.21	No	Yes	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R71	21.46	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y75	5.75	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L95	17.66	1	Yes	No	0	6	0	1
L:L:?1	R:R:R99	5.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:E166	7.8	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H261	7.57	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y268	13.81	1	Yes	No	0	7	0	1
R:R:M18	R:R:Y75	10.78	1	Yes	Yes	5	5	2	1
R:R:C67	R:R:L95	4.76	1	No	No	6	6	2	1
R:R:R71	R:R:Y74	5.14	1	Yes	Yes	6	5	1	2
R:R:R71	R:R:Y75	13.38	1	Yes	Yes	6	5	1	1
R:R:E166	R:R:R71	4.65	1	Yes	Yes	4	6	1	1
R:R:Y74	R:R:Y75	3.97	1	Yes	Yes	5	5	2	1
R:R:E166	R:R:Y74	16.83	1	Yes	Yes	4	5	1	2
R:R:H261	R:R:Y75	10.89	1	Yes	Yes	5	5	1	1
R:R:L95	R:R:Y268	5.86	1	No	No	6	7	1	1
R:R:E184	R:R:R99	5.82	0	No	No	5	8	2	1
R:R:E166	R:R:H261	9.85	1	Yes	Yes	4	5	1	1
R:R:H257	R:R:H261	16.72	0	No	Yes	4	5	2	1
L:L:?1	R:R:L92	2.72	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	264
Number of Links	285
Number of Hubs	39
Number of Links mediated by Hubs	140
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	109
Number Of Links MetaPath	108
Number of Shortest Paths	46287
Length Of Smallest Path	3
Average Path Length	12.2144
Length of Longest Path	24
Minimum Path Strength	1.355
Average Path Strength	6.42242
Maximum Path Strength	19.56
Minimum Path Correlation	0.7
Average Path Correlation	0.923219
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	50.9921
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5396
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC0
Sequence	>9IZD_nogp_Chain_R C C R I E G D T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H M K T W K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R R R H W A F G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H P H H A V N T I S T R V A A G I V C T L W A L V I L G T V Y L L L E N H L C V Q E T A V S C E S F I M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q Q L A R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T V P S S A C D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZD	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	3.16	2025-04-02	To be published
	9IZD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	CHBA	-		3.16	2025-04-02	To be published
	9J8Z	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	3.36	2025-04-02	To be published
	9J8Z (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₁	Homo sapiens	-	-		3.36	2025-04-02	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9IZD_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.