psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D26	8.86	Yes	No	1	0	4
2	L:L:?1	R:R:W28	7.44	Yes	No	1	0	2
3	L:L:?1	R:R:F29	28.92	Yes	Yes	1	0	2
4	L:L:?1	R:R:K34	7.53	Yes	Yes	1	0	3
5	L:L:?1	R:R:Y95	7.65	Yes	Yes	1	0	5
6	L:L:?1	R:R:N99	5.7	Yes	Yes	1	0	4
7	L:L:?1	R:R:D187	15.3	Yes	No	1	0	5
8	L:L:?1	R:R:T188	5.25	Yes	Yes	1	0	3
9	L:L:?1	R:R:Y268	4.87	Yes	Yes	1	0	5
10	L:L:?1	R:R:R272	15.14	Yes	Yes	1	0	3
11	L:L:?1	R:R:K289	6.7	Yes	Yes	1	0	5
12	L:L:?1	R:R:R292	7.93	Yes	Yes	1	0	6
13	R:R:K179	R:R:L25	9.87	No	No	0	3	4
14	R:R:D26	R:R:W28	4.47	No	No	1	4	2
15	R:R:C27	R:R:C278	7.28	No	No	0	9	8
16	R:R:F29	R:R:Y268	7.22	Yes	Yes	1	2	5
17	R:R:F29	R:R:L281	8.53	Yes	No	0	2	3
18	R:R:F29	R:R:N282	4.83	Yes	No	0	2	3
19	R:R:F29	R:R:N285	9.67	Yes	No	1	2	4
20	R:R:D30	R:R:N282	8.08	No	No	0	3	3
21	R:R:D30	R:R:V286	4.38	No	No	0	3	1
22	R:R:F33	R:R:V286	5.24	No	No	0	5	1
23	R:R:F35	R:R:K34	6.2	Yes	Yes	1	4	3
24	R:R:K34	R:R:L38	5.64	Yes	Yes	1	3	6
25	R:R:K34	R:R:Y95	7.17	Yes	Yes	1	3	5
26	R:R:K34	R:R:N99	4.2	Yes	Yes	1	3	4
27	R:R:K289	R:R:K34	12.93	Yes	Yes	1	5	3
28	R:R:F35	R:R:H98	15.84	Yes	No	0	4	3
29	R:R:F35	R:R:N99	10.87	Yes	Yes	1	4	4
30	R:R:L37	R:R:S41	4.5	No	No	0	5	5
31	R:R:L38	R:R:Y42	12.89	Yes	Yes	1	6	8
32	R:R:L38	R:R:Y95	10.55	Yes	Yes	1	6	5
33	R:R:P293	R:R:S41	7.13	No	No	0	5	5
34	R:R:I92	R:R:Y42	4.84	No	Yes	0	6	8
35	R:R:Y42	R:R:Y95	5.96	Yes	Yes	1	8	5
36	R:R:R292	R:R:Y42	5.14	Yes	Yes	1	6	8
37	R:R:S296	R:R:Y42	7.63	No	Yes	0	7	8
38	R:R:S296	R:R:V45	4.85	No	No	0	7	7
39	R:R:C300	R:R:V45	5.12	No	No	0	8	7
40	R:R:F46	R:R:L50	4.87	No	No	0	7	6
41	R:R:F46	R:R:P89	7.22	No	No	0	7	9
42	R:R:C300	R:R:L48	4.76	No	No	0	8	6
43	R:R:L50	R:R:V85	5.96	No	No	0	6	6
44	R:R:L52	R:R:V304	4.47	No	No	0	7	7
45	R:R:D81	R:R:N53	10.77	Yes	No	0	9	9
46	R:R:N53	R:R:P303	11.4	No	No	0	9	9
47	R:R:F60	R:R:T56	5.19	Yes	No	5	7	8
48	R:R:L307	R:R:T56	7.37	No	No	5	7	8
49	R:R:F75	R:R:L57	4.87	Yes	No	0	6	7
50	R:R:L57	R:R:T82	4.42	No	No	0	7	7
51	R:R:F62	R:R:W58	8.02	No	No	0	4	4
52	R:R:L59	R:R:R63	17.01	No	Yes	0	8	4
53	R:R:F60	R:R:P66	4.33	Yes	No	0	7	6
54	R:R:F60	R:R:M74	4.98	Yes	No	0	7	8
55	R:R:F60	R:R:F75	7.5	Yes	Yes	0	7	6
56	R:R:F60	R:R:L307	6.09	Yes	No	5	7	7
57	R:R:F62	R:R:I61	7.54	No	No	0	4	3
58	R:R:L64	R:R:R63	14.58	No	Yes	0	5	4
59	R:R:R315	R:R:R63	12.79	No	Yes	0	4	4
60	R:R:Q319	R:R:R63	22.2	No	Yes	0	4	4
61	R:R:R65	R:R:W67	9	No	No	0	5	7
62	R:R:T72	R:R:W67	8.49	No	No	0	6	7
63	R:R:F75	R:R:W67	7.02	Yes	No	0	6	7
64	R:R:A69	R:R:H132	7.32	No	No	0	7	8
65	R:R:H132	R:R:T70	6.85	No	No	0	8	7
66	R:R:A152	R:R:T72	5.03	No	No	0	7	6
67	R:R:I129	R:R:Y73	4.84	No	Yes	0	8	7
68	R:R:H132	R:R:Y73	7.62	No	Yes	0	8	7
69	R:R:A152	R:R:Y73	5.34	No	Yes	0	7	7
70	R:R:M74	R:R:Y306	4.79	No	No	0	8	9
71	R:R:F125	R:R:H76	12.44	Yes	No	2	7	9
72	R:R:C156	R:R:H76	16.22	No	No	2	8	9
73	R:R:H76	R:R:W160	6.35	No	Yes	2	9	9
74	R:R:D81	R:R:L77	6.79	Yes	No	4	9	9
75	R:R:L126	R:R:L77	4.15	No	No	4	8	9
76	R:R:D302	R:R:L77	12.21	Yes	No	4	9	9
77	R:R:L79	R:R:L83	4.15	No	No	0	6	7
78	R:R:L79	R:R:W160	5.69	No	Yes	0	6	9
79	R:R:C121	R:R:S80	5.16	No	Yes	2	7	8
80	R:R:S122	R:R:S80	4.89	No	Yes	0	9	8
81	R:R:F125	R:R:S80	6.61	Yes	Yes	2	7	8
82	R:R:S80	R:R:W160	6.18	Yes	Yes	2	8	9
83	R:R:D81	R:R:S299	4.42	Yes	No	0	9	9
84	R:R:D302	R:R:D81	9.31	Yes	Yes	4	9	9
85	R:R:L83	R:R:N118	8.24	No	Yes	0	7	8
86	R:R:F115	R:R:Y84	14.44	No	Yes	0	6	7
87	R:R:N118	R:R:Y84	5.81	Yes	Yes	0	8	7
88	R:R:L119	R:R:Y84	8.21	No	Yes	0	8	7
89	R:R:S296	R:R:Y84	6.36	No	Yes	0	7	7
90	R:R:S299	R:R:Y84	5.09	No	Yes	0	9	7
91	R:R:L114	R:R:S87	4.5	No	No	0	5	6
92	R:R:L88	R:R:L91	4.15	No	No	0	8	6
93	R:R:I92	R:R:L88	4.28	No	No	0	6	8
94	R:R:T90	R:R:W101	9.7	No	Yes	3	6	8
95	R:R:F103	R:R:T90	5.19	No	No	3	7	6
96	R:R:T90	R:R:V111	4.76	No	No	0	6	6
97	R:R:L91	R:R:R112	8.5	No	Yes	0	6	5
98	R:R:P102	R:R:Y93	4.17	No	No	0	2	4
99	R:R:F103	R:R:Y93	6.19	No	No	0	7	4
100	R:R:Y94	R:R:Y95	4.96	Yes	Yes	0	5	5
101	R:R:N99	R:R:Y94	11.63	Yes	Yes	0	4	5
102	R:R:W101	R:R:Y94	7.72	Yes	Yes	0	8	5
103	R:R:R112	R:R:Y94	4.12	Yes	Yes	0	5	5
104	R:R:R292	R:R:Y95	6.17	Yes	Yes	1	6	5
105	R:R:L184	R:R:N99	4.12	No	Yes	0	3	4
106	R:R:H100	R:R:P102	6.1	No	No	0	4	2
107	R:R:H100	R:R:T182	13.69	No	No	0	4	1
108	R:R:F103	R:R:W101	5.01	No	Yes	3	7	8
109	R:R:I107	R:R:W101	4.7	No	Yes	0	6	8
110	R:R:C108	R:R:W101	7.84	No	Yes	3	9	8
111	R:R:C185	R:R:W101	13.06	No	Yes	3	9	8
112	R:R:K109	R:R:T105	4.5	No	No	0	7	3
113	R:R:T105	R:R:T176	4.71	No	No	0	3	5
114	R:R:C108	R:R:C185	7.28	No	No	3	9	9
115	R:R:R112	R:R:V174	6.54	Yes	No	0	5	5
116	R:R:C185	R:R:R112	4.18	No	Yes	0	9	5
117	R:R:D187	R:R:R112	20.25	No	Yes	0	5	5
118	R:R:F113	R:R:W117	12.03	No	Yes	0	6	5
119	R:R:F113	R:R:L171	8.53	No	No	0	6	5
120	R:R:L114	R:R:N118	8.24	No	Yes	0	5	8
121	R:R:F115	R:R:Y116	11.35	No	No	0	6	4
122	R:R:N170	R:R:Y116	4.65	No	No	0	3	4
123	R:R:R265	R:R:Y116	12.35	Yes	No	0	5	4
124	R:R:N118	R:R:W117	4.52	Yes	Yes	0	8	5
125	R:R:W117	R:R:W160	10.31	Yes	Yes	0	5	9
126	R:R:V163	R:R:W117	6.13	No	Yes	0	8	5
127	R:R:A164	R:R:W117	5.19	No	Yes	0	4	5
128	R:R:M205	R:R:Y120	4.79	Yes	Yes	1	5	7
129	R:R:L208	R:R:Y120	7.03	Yes	Yes	0	6	7
130	R:R:H262	R:R:Y120	6.53	Yes	Yes	1	8	7
131	R:R:R265	R:R:Y120	4.12	Yes	Yes	1	5	7
132	R:R:C121	R:R:W160	7.84	No	Yes	2	7	9
133	R:R:F258	R:R:V123	7.87	No	No	0	9	8
134	R:R:L124	R:R:V159	5.96	No	No	0	6	7
135	R:R:L124	R:R:P212	6.57	No	No	0	6	9
136	R:R:C156	R:R:F125	6.98	No	Yes	2	8	7
137	R:R:F125	R:R:V159	9.18	Yes	No	0	7	7
138	R:R:F125	R:R:W160	12.03	Yes	Yes	2	7	9
139	R:R:F254	R:R:L126	4.87	No	No	0	9	8
140	R:R:D302	R:R:L126	6.79	Yes	No	4	9	8
141	R:R:P212	R:R:T127	6.99	No	No	0	9	7
142	R:R:T127	R:R:T216	6.28	No	No	0	7	8
143	R:R:I129	R:R:Y306	7.25	No	No	0	8	9
144	R:R:S130	R:R:T216	9.59	No	No	0	9	8
145	R:R:S130	R:R:Y220	6.36	No	Yes	0	9	8
146	R:R:R133	R:R:Y220	8.23	No	Yes	0	9	8
147	R:R:R133	R:R:Y306	7.2	No	No	0	9	9
148	R:R:C138	R:R:Y134	6.72	No	Yes	7	7	8
149	R:R:H139	R:R:Y134	9.8	Yes	Yes	7	6	8
150	R:R:C219	R:R:Y134	6.72	No	Yes	0	8	8
151	R:R:L222	R:R:Y134	7.03	No	Yes	0	4	8
152	R:R:C138	R:R:H139	7.37	No	Yes	7	7	6
153	R:R:H139	R:R:R142	7.9	Yes	No	0	6	5
154	R:R:R142	R:R:R145	7.46	No	No	0	5	4
155	R:R:R142	R:R:W146	11	No	No	0	5	4
156	R:R:L154	R:R:R150	6.07	No	No	0	2	4
157	R:R:L208	R:R:V163	4.47	Yes	No	0	6	8
158	R:R:L167	R:R:V204	4.47	No	No	0	7	5
159	R:R:F200	R:R:P169	10.11	Yes	No	0	4	8
160	R:R:F200	R:R:N170	8.46	Yes	No	0	4	3
161	R:R:F173	R:R:T189	14.27	Yes	No	1	5	5
162	R:R:E193	R:R:F173	4.66	No	Yes	1	4	5
163	R:R:F173	R:R:H196	9.05	Yes	No	0	5	3
164	R:R:F173	R:R:Y197	10.32	Yes	Yes	1	5	4
165	R:R:F173	R:R:F200	9.65	Yes	Yes	1	5	4
166	R:R:R190	R:R:T175	11.64	No	No	0	4	4
167	R:R:H186	R:R:S177	8.37	No	No	0	3	1
168	R:R:R190	R:R:S177	9.22	No	No	0	4	1
169	R:R:L184	R:R:T181	5.9	No	No	0	3	5
170	R:R:H186	R:R:L184	7.71	No	No	0	3	3
171	R:R:D187	R:R:R292	5.96	No	Yes	1	5	6
172	R:R:F194	R:R:T188	9.08	No	Yes	1	2	3
173	R:R:T188	R:R:Y197	7.49	Yes	Yes	1	3	4
174	R:R:R272	R:R:T188	5.17	Yes	Yes	1	3	3
175	R:R:E193	R:R:T189	5.64	No	No	1	4	5
176	R:R:T189	R:R:Y197	4.99	No	Yes	1	5	4
177	R:R:E192	R:R:R190	11.63	No	No	0	4	4
178	R:R:F194	R:R:R272	14.97	No	Yes	1	2	3
179	R:R:D195	R:R:L273	5.43	No	No	0	1	1
180	R:R:F200	R:R:Y197	6.19	Yes	Yes	1	4	4
181	R:R:S201	R:R:Y197	8.9	No	Yes	0	5	4
182	R:R:L273	R:R:V198	8.94	No	No	0	1	2
183	R:R:F200	R:R:V204	5.24	Yes	No	0	4	5
184	R:R:S201	R:R:Y269	5.09	No	No	0	5	5
185	R:R:L208	R:R:V204	4.47	Yes	No	0	6	5
186	R:R:H262	R:R:M205	5.25	Yes	Yes	1	8	5
187	R:R:M205	R:R:R265	9.93	Yes	Yes	1	5	5
188	R:R:C213	R:R:F209	11.17	No	Yes	0	6	8
189	R:R:F209	R:R:H262	29.41	Yes	Yes	0	8	8
190	R:R:L217	R:R:L251	4.15	No	No	0	5	8
191	R:R:M223	R:R:Y220	8.38	No	Yes	6	8	8
192	R:R:I247	R:R:Y220	7.25	No	Yes	6	7	8
193	R:R:V250	R:R:Y220	5.05	No	Yes	0	8	8
194	R:R:L251	R:R:Y220	5.86	No	Yes	0	8	8
195	R:R:L222	R:R:R225	4.86	No	No	0	4	2
196	R:R:I247	R:R:M223	7.29	No	No	6	7	8
197	R:R:L227	R:R:S243	4.5	No	No	0	8	8
198	R:R:L244	R:R:Y228	4.69	No	No	0	6	4
199	R:R:L231	R:R:Q229	7.99	No	No	0	3	5
200	R:R:T246	R:R:T309	4.71	No	Yes	0	8	6
201	R:R:L305	R:R:V250	5.96	No	No	0	8	8
202	R:R:L305	R:R:V253	4.47	No	No	0	8	7
203	R:R:F254	R:R:F258	7.5	No	No	0	9	9
204	R:R:C257	R:R:N298	9.45	No	No	0	9	9
205	R:R:F258	R:R:N298	14.5	No	No	0	9	9
206	R:R:F261	R:R:H262	11.31	Yes	Yes	1	6	8
207	R:R:F261	R:R:R265	5.34	Yes	Yes	1	6	5
208	R:R:F261	R:R:Y288	8.25	Yes	Yes	1	6	4
209	R:R:A295	R:R:F261	8.32	No	Yes	0	8	6
210	R:R:T264	R:R:V287	4.76	No	No	0	5	4
211	R:R:T264	R:R:T291	14.13	No	No	0	5	6
212	R:R:R265	R:R:Y269	15.43	Yes	No	0	5	5
213	R:R:R265	R:R:Y288	13.38	Yes	Yes	1	5	4
214	R:R:Y268	R:R:Y269	4.96	Yes	No	0	5	5
215	R:R:R272	R:R:Y268	17.49	Yes	Yes	1	3	5
216	R:R:V284	R:R:Y268	7.57	Yes	Yes	0	5	5
217	R:R:N285	R:R:Y268	9.3	No	Yes	1	4	5
218	R:R:Y268	R:R:Y288	9.93	Yes	Yes	1	5	4
219	R:R:D277	R:R:V280	4.38	No	No	0	5	1
220	R:R:K289	R:R:N285	11.19	Yes	No	1	5	4
221	R:R:K289	R:R:Y288	5.97	Yes	Yes	1	5	4
222	R:R:R292	R:R:Y288	5.14	Yes	Yes	1	6	4
223	R:R:K289	R:R:R292	6.19	Yes	Yes	1	5	6
224	R:R:D302	R:R:N298	10.77	Yes	No	0	9	9
225	R:R:L308	R:R:Y313	16.41	No	No	0	7	8
226	R:R:T309	R:R:Y313	4.99	Yes	No	0	6	8
227	R:R:D311	R:R:R315	8.34	No	No	0	4	4
228	R:R:K312	R:R:R315	17.33	No	No	0	6	4
229	R:R:C128	R:R:Y73	4.03	No	Yes	0	7	7
230	R:R:R242	R:R:T309	3.88	No	Yes	0	7	6
231	R:R:F75	R:R:I61	3.77	Yes	No	0	6	3
232	R:R:T264	R:R:Y288	3.75	No	Yes	0	5	4
233	R:R:A96	R:R:P39	3.74	No	No	0	4	5
234	R:R:A71	R:R:P66	3.74	No	No	0	8	6
235	R:R:A235	R:R:P232	3.74	No	Yes	0	3	3
236	R:R:F60	R:R:K312	3.72	Yes	No	0	7	6
237	R:R:G49	R:R:V85	3.68	No	No	0	8	6
238	R:R:G165	R:R:V168	3.68	No	No	0	5	4
239	R:R:P169	R:R:V168	3.53	No	No	0	8	4
240	R:R:P212	R:R:V211	3.53	No	No	0	9	5
241	R:R:P260	R:R:V259	3.53	No	Yes	0	9	5
242	R:R:E31	R:R:F35	3.5	No	Yes	0	3	4
243	R:R:C219	R:R:S130	3.44	No	No	0	8	9
244	R:R:L135	R:R:W146	3.42	No	No	0	6	4
245	R:R:C108	R:R:T176	3.38	No	No	0	9	5
246	R:R:L38	R:R:P293	3.28	Yes	No	0	6	5
247	R:R:L52	R:R:P303	3.28	No	No	0	7	9
248	R:R:S237	R:R:S239	3.26	No	No	0	4	5
249	R:R:S299	R:R:V85	3.23	No	No	0	9	6
250	R:R:T127	R:R:V215	3.17	No	No	0	7	6
251	R:R:C166	R:R:L167	3.17	No	No	0	5	7
252	R:R:C166	R:R:L208	3.17	No	Yes	0	5	6
253	R:R:T182	R:R:V183	3.17	No	No	0	1	4
254	R:R:A71	R:R:D68	3.09	No	No	0	8	7
255	R:R:I263	R:R:V259	3.07	No	Yes	0	5	5
256	R:R:I267	R:R:V284	3.07	No	Yes	0	5	5
257	R:R:K179	R:R:S177	3.06	No	No	0	3	1
258	R:R:H186	R:R:P191	3.05	No	No	0	3	3
259	R:R:F209	R:R:G210	3.01	Yes	No	0	8	4
260	R:R:G147	R:R:R148	3	No	Yes	0	7	7
261	R:R:L37	R:R:V290	2.98	No	No	0	5	6
262	R:R:L135	R:R:V131	2.98	No	No	0	6	7
263	R:R:L222	R:R:V218	2.98	No	No	0	4	4
264	R:R:L301	R:R:V253	2.98	No	No	0	6	7
265	R:R:N178	R:R:V183	2.96	No	No	0	2	4
266	R:R:I137	R:R:M223	2.92	No	No	0	8	8
267	R:R:G180	R:R:W28	2.81	No	No	0	2	2
268	R:R:G104	R:R:W101	2.81	No	Yes	0	7	8
269	R:R:C138	R:R:R226	2.79	No	No	0	7	5
270	R:R:P39	R:R:Y95	2.78	No	Yes	0	5	5
271	R:R:L227	R:R:L244	2.77	No	No	0	8	6
272	R:R:L59	R:R:Q316	2.66	No	No	0	8	5
273	R:R:L320	R:R:Q316	2.66	No	No	0	4	5
274	R:R:F46	R:R:V47	2.62	No	No	0	7	5
275	R:R:F172	R:R:V168	2.62	No	No	0	4	4
276	R:R:F194	R:R:V198	2.62	No	No	0	2	2
277	R:R:F209	R:R:V259	2.62	Yes	Yes	0	8	5
278	R:R:A54	R:R:W58	2.59	No	No	0	4	4
279	R:R:F110	R:R:L114	2.44	No	No	0	5	5
280	R:R:L151	R:R:R148	2.43	No	Yes	0	3	7
281	R:R:L155	R:R:Y73	2.34	No	Yes	0	6	7
282	R:R:G233	R:R:P232	2.03	No	Yes	0	3	3
283	R:R:A143	R:R:G136	1.95	No	No	0	5	8
284	R:R:A152	R:R:G153	1.95	No	No	0	7	3
285	R:R:A224	R:R:G221	1.95	No	No	0	5	4
286	R:R:A54	R:R:P55	1.87	No	No	0	4	6
287	R:R:G310	R:R:T309	1.82	No	Yes	0	8	6
288	R:R:G206	R:R:M205	1.75	No	Yes	0	4	5
289	R:R:G136	R:R:L135	1.71	No	No	0	8	6
290	R:R:A255	R:R:V259	1.7	No	Yes	0	6	5
291	R:R:A271	R:R:V284	1.7	No	Yes	0	1	5
292	R:R:A276	R:R:V280	1.7	No	No	0	2	1
293	R:R:D311	R:R:G310	1.68	No	No	0	4	8
294	R:R:L231	R:R:P232	1.64	No	Yes	0	3	3
295	R:R:L294	R:R:P260	1.64	No	No	0	7	9
296	R:R:A224	R:R:I247	1.62	No	No	0	5	7
297	R:R:V249	R:R:V253	1.6	No	No	0	6	7
298	R:R:V280	R:R:V284	1.6	No	Yes	0	1	5
299	R:R:A78	R:R:L57	1.58	No	No	0	8	7
300	R:R:A224	R:R:L244	1.58	No	No	0	5	6
301	R:R:P230	R:R:Q229	1.58	No	No	0	5	5
302	R:R:P230	R:R:Q236	1.58	No	No	0	5	3
303	R:R:C278	R:R:N282	1.57	No	No	0	8	3
304	R:R:I283	R:R:V287	1.54	No	No	0	3	4
305	R:R:H139	R:R:P140	1.53	Yes	No	0	6	8
306	R:R:I267	R:R:T266	1.52	No	No	0	5	5
307	R:R:L48	R:R:V44	1.49	No	No	0	6	5
308	R:R:L294	R:R:V256	1.49	No	No	0	7	5
309	R:R:A97	R:R:H100	1.46	No	No	0	5	4
310	R:R:P149	R:R:R148	1.44	No	Yes	0	4	7
311	R:R:P232	R:R:R240	1.44	Yes	No	0	3	6
312	R:R:Q236	R:R:S234	1.44	No	No	0	3	4
313	R:R:I36	R:R:L37	1.43	No	No	0	5	5
314	R:R:D32	R:R:I36	1.4	No	No	0	3	5
315	R:R:L50	R:R:L86	1.38	No	No	0	6	4
316	R:R:L141	R:R:L144	1.38	No	No	0	6	5
317	R:R:L151	R:R:L155	1.38	No	No	0	3	6
318	R:R:L157	R:R:L161	1.38	No	No	0	3	4
319	R:R:L207	R:R:L208	1.38	No	Yes	0	4	6
320	R:R:D195	R:R:H199	1.26	No	No	0	1	3
321	R:R:L231	R:R:R226	1.21	No	No	0	3	5
322	R:R:L227	R:R:R240	1.21	No	No	0	8	6
323	R:R:Q319	R:R:R318	1.17	No	No	0	4	4
324	R:R:R148	R:R:R150	1.07	Yes	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.1075	12	1	0
2	R:R:F29	11.834	5	1	2
3	R:R:K34	7.27833	6	1	3
4	R:R:F35	9.1025	4	1	4
5	R:R:L38	8.09	4	1	6
6	R:R:Y42	7.292	5	1	8
7	R:R:F60	5.30167	6	5	7
8	R:R:R63	16.645	4	0	4
9	R:R:Y73	4.834	5	0	7
10	R:R:F75	5.79	4	0	6
11	R:R:S80	5.71	4	2	8
12	R:R:D81	7.8225	4	4	9
13	R:R:Y84	7.982	5	0	7
14	R:R:Y94	7.1075	4	0	5
15	R:R:Y95	6.46286	7	1	5
16	R:R:N99	7.304	5	1	4
17	R:R:W101	7.26286	7	3	8
18	R:R:R112	8.718	5	0	5
19	R:R:W117	7.636	5	0	5
20	R:R:N118	6.7025	4	0	8
21	R:R:Y120	5.6175	4	1	7
22	R:R:F125	9.448	5	2	7
23	R:R:Y134	7.5675	4	7	8
24	R:R:H139	6.65	4	7	6
25	R:R:R148	1.985	4	0	7
26	R:R:W160	8.06667	6	2	9
27	R:R:F173	9.59	5	1	5
28	R:R:T188	6.7475	4	1	3
29	R:R:Y197	7.578	5	1	4
30	R:R:F200	7.93	5	1	4
31	R:R:M205	5.43	4	1	5
32	R:R:L208	4.104	5	0	6
33	R:R:F209	11.5525	4	0	8
34	R:R:Y220	6.855	6	6	8
35	R:R:P232	2.2125	4	0	3
36	R:R:V259	2.73	4	0	5
37	R:R:F261	8.305	4	1	6
38	R:R:H262	13.125	4	1	8
39	R:R:R265	10.0917	6	1	5
40	R:R:Y268	8.76286	7	1	5
41	R:R:R272	13.1925	4	1	3
42	R:R:V284	3.485	4	0	5
43	R:R:Y288	7.73667	6	1	4
44	R:R:K289	8.596	5	1	5
45	R:R:R292	6.08833	6	1	6
46	R:R:D302	9.77	4	4	9
47	R:R:T309	3.85	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N99	21.36	5.7	Yes	Yes	1	0	4
2	R:R:L184	R:R:N99	34.2918	4.12	No	Yes	0	3	4
3	R:R:H186	R:R:L184	27.4881	7.71	No	No	0	3	3
4	R:R:H186	R:R:S177	20.6568	8.37	No	No	0	3	1
5	L:L:?1	R:R:F29	11.8752	28.92	Yes	Yes	1	0	2
6	R:R:F29	R:R:N282	14.6707	4.83	Yes	No	0	2	3
7	R:R:K34	R:R:L38	10.1535	5.64	Yes	Yes	1	3	6
8	L:L:?1	R:R:Y95	20.7192	7.65	Yes	Yes	1	0	5
9	R:R:Y42	R:R:Y95	42.5884	5.96	Yes	Yes	1	8	5
10	L:L:?1	R:R:R292	17.3485	7.93	Yes	Yes	1	0	6
11	R:R:R292	R:R:Y42	22.2365	5.14	Yes	Yes	1	6	8
12	R:R:S296	R:R:Y42	75.8825	7.63	No	Yes	0	7	8
13	R:R:S296	R:R:Y84	75.0165	6.36	No	Yes	0	7	7
14	R:R:S299	R:R:Y84	31.2294	5.09	No	Yes	0	9	7
15	R:R:D81	R:R:S299	20.7815	4.42	Yes	No	0	9	9
16	R:R:N118	R:R:Y84	70.9218	5.81	Yes	Yes	0	8	7
17	R:R:N118	R:R:W117	67.7971	4.52	Yes	Yes	0	8	5
18	R:R:W117	R:R:W160	100	10.31	Yes	Yes	0	5	9
19	R:R:F125	R:R:W160	95.7322	12.03	Yes	Yes	2	7	9
20	R:R:F125	R:R:V159	96.0024	9.18	Yes	No	0	7	7
21	R:R:L124	R:R:V159	95.4065	5.96	No	No	0	6	7
22	R:R:L124	R:R:P212	94.8038	6.57	No	No	0	6	9
23	R:R:P212	R:R:T127	93.5774	6.99	No	No	0	9	7
24	R:R:T127	R:R:T216	92.3234	6.28	No	No	0	7	8
25	R:R:S130	R:R:T216	91.686	9.59	No	No	0	9	8
26	R:R:S130	R:R:Y220	72.5326	6.36	No	Yes	0	9	8
27	R:R:R133	R:R:Y220	57.7753	8.23	No	Yes	0	9	8
28	R:R:R133	R:R:Y306	56.8331	7.2	No	No	0	9	9
29	R:R:M74	R:R:Y306	39.0377	4.79	No	No	0	8	9
30	R:R:F60	R:R:M74	37.9638	4.98	Yes	No	0	7	8
31	R:R:F60	R:R:F75	13.4721	7.5	Yes	Yes	0	7	6
32	R:R:F60	R:R:K312	19.6557	3.72	Yes	No	0	7	6
33	R:R:K312	R:R:R315	18.5471	17.33	No	No	0	6	4
34	R:R:I129	R:R:Y306	19.0633	7.25	No	No	0	8	9
35	R:R:I129	R:R:Y73	17.9063	4.84	No	Yes	0	8	7
36	R:R:Y268	R:R:Y269	10.8394	4.96	Yes	No	0	5	5
37	R:R:R265	R:R:Y269	11.2932	15.43	Yes	No	0	5	5
38	R:R:Y268	R:R:Y288	13.3059	9.93	Yes	Yes	1	5	4
39	R:R:R265	R:R:Y288	16.9086	13.38	Yes	Yes	1	5	4
40	R:R:Y94	R:R:Y95	23.778	4.96	Yes	Yes	0	5	5
41	R:R:W101	R:R:Y94	19.7457	7.72	Yes	Yes	0	8	5
42	R:R:N99	R:R:Y94	10.6107	11.63	Yes	Yes	0	4	5
43	L:L:?1	R:R:T188	10.3336	5.25	Yes	Yes	1	0	3
44	R:R:T188	R:R:Y197	10.2955	7.49	Yes	Yes	1	3	4
45	R:R:F200	R:R:V204	10.4167	5.24	Yes	No	0	4	5
46	R:R:L208	R:R:V204	10.4237	4.47	Yes	No	0	6	5
47	R:R:L208	R:R:V163	37.1185	4.47	Yes	No	0	6	8
48	R:R:R265	R:R:Y120	23.6741	4.12	Yes	Yes	1	5	7
49	R:R:L208	R:R:Y120	28.7941	7.03	Yes	Yes	0	6	7
50	R:R:C219	R:R:S130	27.8311	3.44	No	No	0	8	9
51	R:R:C219	R:R:Y134	26.7018	6.72	No	Yes	0	8	8
52	R:R:C138	R:R:Y134	11.2308	6.72	No	Yes	7	7	8
53	R:R:H139	R:R:Y134	10.9364	9.8	Yes	Yes	7	6	8
54	R:R:R190	R:R:S177	10.3578	9.22	No	No	0	4	1
55	R:R:F209	R:R:H262	12.374	29.41	Yes	Yes	0	8	8
56	R:R:I247	R:R:Y220	10.2851	7.25	No	Yes	6	7	8
57	R:R:C138	R:R:R226	10.4687	2.79	No	No	0	7	5
58	R:R:V284	R:R:Y268	14.6188	7.57	Yes	Yes	0	5	5
59	R:R:V163	R:R:W117	37.0215	6.13	No	Yes	0	8	5
60	R:R:K34	R:R:N99	13.3301	4.2	Yes	Yes	1	3	4
61	R:R:L38	R:R:Y42	12.4294	12.89	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D26	8.86	1	Yes	No	0	4	0	1
L:L:?1	R:R:W28	7.44	1	Yes	No	0	2	0	1
L:L:?1	R:R:F29	28.92	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:K34	7.53	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y95	7.65	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N99	5.7	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:D187	15.3	1	Yes	No	0	5	0	1
L:L:?1	R:R:T188	5.25	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y268	4.87	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R272	15.14	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:K289	6.7	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R292	7.93	1	Yes	Yes	0	6	0	1
R:R:D26	R:R:W28	4.47	1	No	No	4	2	1	1
R:R:F29	R:R:Y268	7.22	1	Yes	Yes	2	5	1	1
R:R:F29	R:R:L281	8.53	1	Yes	No	2	3	1	2
R:R:F29	R:R:N282	4.83	1	Yes	No	2	3	1	2
R:R:F29	R:R:N285	9.67	1	Yes	No	2	4	1	2
R:R:F35	R:R:K34	6.2	1	Yes	Yes	4	3	2	1
R:R:K34	R:R:L38	5.64	1	Yes	Yes	3	6	1	2
R:R:K34	R:R:Y95	7.17	1	Yes	Yes	3	5	1	1
R:R:K34	R:R:N99	4.2	1	Yes	Yes	3	4	1	1
R:R:K289	R:R:K34	12.93	1	Yes	Yes	5	3	1	1
R:R:F35	R:R:N99	10.87	1	Yes	Yes	4	4	2	1
R:R:L38	R:R:Y42	12.89	1	Yes	Yes	6	8	2	2
R:R:L38	R:R:Y95	10.55	1	Yes	Yes	6	5	2	1
R:R:Y42	R:R:Y95	5.96	1	Yes	Yes	8	5	2	1
R:R:R292	R:R:Y42	5.14	1	Yes	Yes	6	8	1	2
R:R:Y94	R:R:Y95	4.96	0	Yes	Yes	5	5	2	1
R:R:N99	R:R:Y94	11.63	1	Yes	Yes	4	5	1	2
R:R:R112	R:R:Y94	4.12	0	Yes	Yes	5	5	2	2
R:R:R292	R:R:Y95	6.17	1	Yes	Yes	6	5	1	1
R:R:L184	R:R:N99	4.12	0	No	Yes	3	4	2	1
R:R:D187	R:R:R112	20.25	1	No	Yes	5	5	1	2
R:R:D187	R:R:R292	5.96	1	No	Yes	5	6	1	1
R:R:F194	R:R:T188	9.08	1	No	Yes	2	3	2	1
R:R:T188	R:R:Y197	7.49	1	Yes	Yes	3	4	1	2
R:R:R272	R:R:T188	5.17	1	Yes	Yes	3	3	1	1
R:R:F194	R:R:R272	14.97	1	No	Yes	2	3	2	1
R:R:Y268	R:R:Y269	4.96	1	Yes	No	5	5	1	2
R:R:R272	R:R:Y268	17.49	1	Yes	Yes	3	5	1	1
R:R:V284	R:R:Y268	7.57	0	Yes	Yes	5	5	2	1
R:R:N285	R:R:Y268	9.3	1	No	Yes	4	5	2	1
R:R:Y268	R:R:Y288	9.93	1	Yes	Yes	5	4	1	2
R:R:K289	R:R:N285	11.19	1	Yes	No	5	4	1	2
R:R:K289	R:R:Y288	5.97	1	Yes	Yes	5	4	1	2
R:R:R292	R:R:Y288	5.14	1	Yes	Yes	6	4	1	2
R:R:K289	R:R:R292	6.19	1	Yes	Yes	5	6	1	1
R:R:G180	R:R:W28	2.81	0	No	No	2	2	2	1
R:R:P39	R:R:Y95	2.78	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K0K_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.11
Number of Linked Nodes	276
Number of Links	324
Number of Hubs	47
Number of Links mediated by Hubs	175
Number of Communities	7
Number of Nodes involved in Communities	53
Number of Links involved in Communities	83

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	59265
Length Of Smallest Path	3
Average Path Length	15.2372
Length of Longest Path	35
Minimum Path Strength	1.255
Average Path Strength	7.13479
Maximum Path Strength	22.11
Minimum Path Correlation	0.7
Average Path Correlation	0.930065
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	55.9066
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3161
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled pyrimidinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled UTP receptor activity • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • cellular response to ATP • response to organophosphorus • response to ATP • response to purine-containing compound • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • localization • transepithelial chloride transport • transepithelial transport • transport • monoatomic anion transport • monoatomic ion transport • establishment of localization • chloride transport • inorganic anion transport • phospholipase C-activating G protein-coupled receptor signaling pathway • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UTP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UTP
Name	Uridine 5'-triphosphate
Synonyms	Uridine 5'-triphosphate Uridine triphosphate
Identifier
Formula	C9 H15 N2 O15 P3
Molecular Weight	484.141
SMILES
PubChem	6133
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	6
Total Bonds	45
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51582
Sequence	>9K0K_nogp_Chain_R L D C W F D E D F K F I L L P V S Y A V V F V L G L G L N A P T L W L F I F R L R P W D A T A T Y M F H L A L S D T L Y V L S L P T L I Y Y Y A A H N H W P F G T E I C K F V R F L F Y W N L Y C S V L F L T C I S V H R Y L G I C H P L R A L R W G R P R L A G L L C L A V W L V V A G C L V P N L F F V T T S N K G T T V L C H D T T R P E E F D H Y V H F S S A V M G L L F G V P C L V T L V C Y G L M A R R L Y Q P L P G S A Q S S S R L R S L R T I A V V L T V F A V C F V P F H I T R T I Y Y L A R L L E A D C R V L N I V N V V Y K V T R P L A S A N S C L D P V L Y L L T G D K Y R R Q L R Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K0K	A	Nucleotide	P2Y	P2Y₄	Homo sapiens	UTP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0K (No Gprot)	A	Nucleotide	P2Y	P2Y₄	Homo sapiens	UTP	-		3.14	2025-06-11	doi.org/10.1038/s41421-025-00797-x

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Download 9K0K_nogp.zip

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