Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R42 6.6125429
2A:A:N50 5.534126
3A:A:K53 5.165409
4A:A:T55 3.655409
5A:A:F212 7.285409
6A:A:H220 9.8525427
7A:A:F222 9.354527
8A:A:Q227 4.9375429
9A:A:R231 7.7675429
10A:A:K233 8.26529
11A:A:W234 6.616529
12A:A:F238 8.825429
13A:A:Y253 7.64254248
14A:A:D272 6.925428
15A:A:F273 7.115239
16A:A:W281 8.73665
17A:A:F290 4.95409
18A:A:Q294 8.205476
19A:A:L296 5.61754126
20A:A:F315 8.11786
21A:A:Y318 8.61586
22A:A:P321 3.865405
23A:A:E330 5.635403
24A:A:R336 12.0925485
25A:A:Y339 5.4875473
26A:A:F340 11.94487
27A:A:R342 7.9725474
28A:A:F345 8.62754238
29A:A:L346 4.892574
30A:A:Y358 6.905434
31A:A:Y360 6.498538
32A:A:F363 7.298575
33A:A:T364 6.7554169
34A:A:D368 7.2654169
35A:A:R374 7.82254164
36A:A:F376 4.82833638
37A:A:R380 4.9625437
38A:A:R385 7.78535
39A:A:Y391 10.47594
40B:B:L7 2.0125408
41B:B:R22 5.9925416
42B:B:V40 4.4125173
43B:B:R48 5.114147
44B:B:H54 9.5245109
45B:B:K57 11.6275469
46B:B:Y59 10.4775468
47B:B:M61 5.00754106
48B:B:W63 7.1456107
49B:B:D76 9.9175409
50B:B:I81 5.9725447
51B:B:W82 10.69176109
52B:B:K89 7.222509
53B:B:H91 7.0075445
54B:B:I93 5.405407
55B:B:L95 5.746548
56B:B:W99 8.78571729
57B:B:Y105 4.718546
58B:B:Y111 6.125404
59B:B:C114 5.375448
60B:B:N119 4.255429
61B:B:C121 4.1354118
62B:B:I123 4.725406
63B:B:Y124 5.21167646
64B:B:E138 5.1075446
65B:B:Y145 6.69728
66B:B:F151 6.376509
67B:B:T159 6.76254119
68B:B:D163 6.155409
69B:B:C166 4.235418
70B:B:W169 8.664297118
71B:B:T173 5.4625405
72B:B:F180 7.198517
73B:B:H183 7.29833619
74B:B:D186 6.1225429
75B:B:V187 4.426519
76B:B:L190 6.13415
77B:B:F199 5.91833619
78B:B:S201 3.9475419
79B:B:C204 5.276527
80B:B:D205 6.125419
81B:B:K209 13.46416
82B:B:W211 8.16167618
83B:B:Q220 8.078517
84B:B:F222 9.0225418
85B:B:H225 9.516676279
86B:B:D228 10.75429
87B:B:I232 5.7975418
88B:B:F235 7.208577186
89B:B:F241 7.21833616
90B:B:D247 8.8125279
91B:B:R251 11.525408
92B:B:F253 7.2275416
93B:B:D258 8.476517
94B:B:M262 5.0325404
95B:B:Y264 6.395405
96B:B:R283 9.85179
97B:B:L286 5.034257
98B:B:Y289 5.8725197
99B:B:C294 4.2025455
100B:B:N295 7.0485196
101B:B:V296 3.82754255
102B:B:W297 10.164198
103B:B:L300 5.35254176
104B:B:K301 7.014297175
105B:B:R304 10.1154195
106B:B:L308 10.9375457
107B:B:H311 8.78333659
108B:B:R314 13.27568
109B:B:G324 3.1975409
110B:B:M325 5.266145
111B:B:T329 6.0875458
112B:B:W332 11.35769
113B:B:F335 6.6404
114B:B:K337 8.3675456
115B:B:W339 11.28559
116B:B:N340 5.5654149
117G:G:L19 4.175409
118G:G:E22 4.104519
119G:G:I25 5.29412
120G:G:Y40 6.0854186
121G:G:D48 8.0275409
122G:G:L51 4.685406
123G:G:N59 5.965149
124G:G:F61 5.711437148
125R:R:F43 3.832506
126R:R:S50 4.1356158
127R:R:N54 6.483336159
128R:R:I61 3.48254138
129R:R:N64 8.3354137
130R:R:L67 7.834139
131R:R:P70 4.1054286
132R:R:Y72 6.0325138
133R:R:F74 5.4725408
134R:R:S77 5.074299
135R:R:D82 8.48754159
136R:R:S86 5.08254158
137R:R:W91 8.1625407
138R:R:F110 5.3725403
139R:R:F118 5.38406
140R:R:R140 9.444599
141R:R:Y141 11.395438
142R:R:F145 11.102537
143R:R:Y150 5.8156288
144R:R:S159 4.3425407
145R:R:W167 4.41409
146R:R:F194 10.595407
147R:R:L204 4.1525407
148R:R:Y205 5.076599
149R:R:F209 4.03406
150R:R:L211 4.8475435
151R:R:H215 6.91437
152R:R:V240 2.8575408
153R:R:W251 7.696507
154R:R:F254 6.7225405
155R:R:H257 8.37404
156R:R:C264 5.4454213
157R:R:Y280 8.51405
158R:R:M285 4.6425156
159R:R:S288 5.77754159
160R:R:Y295 4.88833699
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:W82 1004.23YesYes1099
2B:B:H54 B:B:S74 47.71589.76YesNo099
3B:B:D76 B:B:S74 47.63210.31YesNo099
4B:B:D76 B:B:L55 43.252813.57YesNo096
5A:A:Y37 B:B:L55 42.60645.86NoNo046
6A:A:R42 A:A:Y37 42.42812.35YesNo094
7R:R:F145 R:R:L211 16.53947.31YesYes375
8R:R:F145 R:R:I144 16.30066.28YesNo079
9A:A:Y391 R:R:I144 17.78653.63YesNo049
10A:A:Y391 R:R:T143 40.2058.74YesNo049
11R:R:T143 R:R:Y150 41.08568.74NoYes098
12R:R:P70 R:R:Y150 67.33784.17YesYes2868
13R:R:P70 R:R:S159 93.12565.34YesYes067
14R:R:F73 R:R:S159 93.42096.61NoYes047
15R:R:F73 R:R:H68 93.51876.79NoNo048
16R:R:H68 R:R:K65 93.616120.96NoNo086
17B:B:F335 R:R:K65 93.71329.93YesNo046
18B:B:D333 B:B:F335 93.3777.17NoYes094
19B:B:D333 B:B:H311 93.115712.61NoYes599
20B:B:H311 B:B:T329 92.86086.85YesYes598
21B:B:L308 B:B:T329 92.59224.42YesYes578
22B:B:L308 B:B:M45 94.48615.65YesNo074
23B:B:M45 B:B:V296 94.66313.04NoYes045
24B:B:L286 B:B:V296 94.74655.96YesYes2575
25B:B:L286 B:B:V327 95.09954.47YesNo076
26B:B:V320 B:B:V327 95.18573.21NoNo076
27B:B:S277 B:B:V320 95.27163.23NoNo057
28B:B:G319 B:B:S277 95.35713.71NoNo055
29B:B:G319 B:B:M61 95.44233.49NoYes056
30B:B:L70 B:B:M61 65.80324.24NoYes1056
31B:B:L70 B:B:W82 97.18234.56NoYes1059
32A:A:F222 A:A:R42 20.96047.48YesYes279
33B:B:H54 B:B:I58 53.013310.61YesNo099
34B:B:I58 B:B:S316 52.91943.1NoNo099
35B:B:S316 B:B:W332 52.82584.94NoYes099
36B:B:W332 B:B:Y59 47.94897.72YesYes698
37B:B:Q75 B:B:Y59 19.565722.55NoYes098
38B:B:Q75 B:B:W99 19.45968.76NoYes099
39A:A:R42 B:B:W99 21.28834YesYes299
40A:A:F238 B:B:W99 38.637811.02YesYes299
41A:A:F222 A:A:F238 20.09783.22YesYes279
42A:A:C237 B:B:Y59 28.49248.06NoYes088
43A:A:C237 B:B:M101 28.35124.86NoNo089
44B:B:M101 B:B:Y145 28.03234.79NoYes098
45A:A:W234 B:B:Y145 19.55936.75YesYes298
46A:A:R231 A:A:W234 74.87458YesYes299
47A:A:F238 A:A:W234 56.88224.01YesYes299
48A:A:D295 A:A:L296 11.76365.43NoYes096
49A:A:C365 A:A:D295 14.36244.67NoNo089
50A:A:C365 A:A:Q294 15.01124.58NoYes086
51A:A:F363 A:A:Q294 17.598311.71YesYes756
52A:A:F363 A:A:R342 19.52758.55YesYes754
53A:A:L346 A:A:R342 22.11937.29YesYes744
54A:A:C359 A:A:L346 56.43623.17NoYes054
55A:A:C359 A:A:L289 58.88894.76NoNo059
56A:A:F273 A:A:L289 59.43167.31YesNo2399
57A:A:F246 A:A:F273 69.54528.57NoYes099
58A:A:D272 A:A:F246 73.35047.17YesNo089
59A:A:D272 A:A:R231 74.095111.91YesYes289
60A:A:L346 R:R:P223 33.02773.28YesNo742
61A:A:D343 R:R:P223 32.39763.22NoNo032
62A:A:D343 A:A:Y318 31.758213.79NoYes036
63A:A:F315 A:A:Y318 14.27793.09YesYes866
64A:A:D331 A:A:R333 13.02533.57NoNo045
65A:A:D331 A:A:L302 10.4234.07NoNo042
66R:R:D139 R:R:Y150 25.88875.75NoYes098
67R:R:D139 R:R:M71 23.27524.16NoNo099
68R:R:M71 R:R:R140 22.92884.96NoYes999
69A:A:Y391 R:R:R140 23.593524.69YesYes949
70R:R:R140 R:R:Y205 43.75786.17YesYes999
71B:B:L70 B:B:W63 31.405411.39NoYes1057
72B:B:T321 B:B:W63 55.969112.13NoYes077
73B:B:G324 B:B:T321 55.6213.64YesNo097
74B:B:G324 G:G:P49 54.38164.06YesNo097
75G:G:D48 G:G:P49 55.40334.83YesNo097
76G:G:D48 G:G:L51 54.85828.14YesYes096
77B:B:R283 G:G:L51 54.12646.07YesYes096
78B:B:L300 B:B:R283 51.20584.86YesYes1769
79B:B:L300 G:G:C41 51.18276.35YesNo067
80B:B:F235 G:G:C41 50.99312.79YesNo067
81B:B:F235 B:B:F278 46.734310.72YesNo067
82B:B:F278 B:B:L285 46.338815.83NoNo076
83B:B:L285 B:B:Y264 45.94184.69NoYes065
84B:B:M262 B:B:Y264 41.89562.39YesYes045
85B:B:M262 B:B:T29 40.65453.01YesNo043
86B:B:Q32 B:B:T29 40.2382.83NoNo013
87B:B:A28 B:B:Q32 40.02923.03NoNo041
88B:B:A28 B:B:D27 39.82014.63NoNo048
89B:B:D27 G:G:K29 39.400811.06NoNo084
90G:G:K29 G:G:V30 38.98013.04NoNo048
91B:B:Q259 G:G:V30 38.76932.87NoNo068
92B:B:Q259 B:B:R22 38.55814.67NoYes066
93B:B:R22 G:G:E22 26.39845.82YesYes169
94B:B:D258 B:B:R22 10.6165.96YesYes176
95B:B:T221 G:G:E22 18.9964.23NoYes179
96B:B:K209 B:B:T221 10.898516.52YesNo167
97R:R:P70 R:R:S69 27.84063.56YesNo067
98R:R:S69 R:R:Y72 27.62316.36NoYes078
99R:R:L201 R:R:Y205 35.97813.52NoYes089
100R:R:F247 R:R:L201 37.33658.53NoNo088
101R:R:F247 R:R:W251 35.46618.02NoYes087
102R:R:I284 R:R:W251 25.692310.57NoYes077
103R:R:F254 R:R:I284 25.28166.28YesNo057
104R:R:F254 R:R:L258 12.290910.96YesNo054
105R:R:H257 R:R:L258 11.8723.86YesNo044
106R:R:H257 R:R:Y280 19.52383.27YesYes045
107R:R:F254 R:R:F277 12.29094.29YesNo054
108R:R:F277 R:R:H257 11.87215.84NoYes044
109R:R:I61 R:R:Y72 24.05344.84YesYes1388
110R:R:C76 R:R:I61 12.34123.27NoYes078
111R:R:C76 R:R:I58 12.14853.27NoNo078
112R:R:A79 R:R:I58 23.90573.25NoNo098
113R:R:A79 R:R:N54 23.53393.13NoYes099
114R:R:I61 R:R:V62 12.34121.54YesNo083
115R:R:I58 R:R:V62 12.14851.54NoNo083
116R:R:M83 R:R:N54 11.65527.01NoYes079
117R:R:L51 R:R:M83 10.80054.24NoNo067
118R:R:L51 R:R:M87 10.37274.24NoNo065
119R:R:F273 R:R:Y280 11.90616.5NoYes045
120B:B:M61 B:B:W63 29.80825.82YesYes1067
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K3H
Class A
SubFamily Peptide
Type Melanocortin
SubType MC5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.86
Date 2025-08-06
D.O.I. doi.org/10.1016/j.str.2025.03.004
Net Summary
Imin 3.04
Number of Linked Nodes 850
Number of Links 1001
Number of Hubs 160
Number of Links mediated by Hubs 587
Number of Communities 30
Number of Nodes involved in Communities 224
Number of Links involved in Communities 316
Path Summary
Number Of Nodes in MetaPath 121
Number Of Links MetaPath 120
Number of Shortest Paths 940981
Length Of Smallest Path 3
Average Path Length 39.2143
Length of Longest Path 71
Minimum Path Strength 1.26
Average Path Strength 6.625
Maximum Path Strength 27
Minimum Path Correlation 0.71
Average Path Correlation 0.977305
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 39.6099
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.5971
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9K3H_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHTSGI 
FETKFQVDK VNFHMFDVG QRDERRKWI QCFNDVTAI IFVVSSYNR 
LQEALNFKS IWNNRWLRT ISVILFLNK QDLLAEKVL AGKSKIEDY 
FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR ISTASGDGR 
HYCYPHFTC VDTENRRFN DCRDIIQRM HLRQYELLL SADAVRSMD 
NYADDDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K3H_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9K3H_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP33032
Sequence
>9K3H_Chain_R
IAVEVFLTL GVISLLENI LVIGAIVKN KNLHSPMYF FVCSLAVAD 
MLVSMSSAW ETITIYLLN NKHLVIADA FVRHIDNVF DSMICISVV 
ASMCSLLAI AVDRYVTIF YALRYHHIM TARRSGAII AGIWAFCTG 
CGIVFILYS ESTYVILCL ISMFFAMLF LLVSLYIHM FLLARTHVK 
RIAALPGAS RTSMQGAVT VTMLLGVFT VCWAPFFLH LTLMLSCPQ 
NLYCSRFMS HFNMYLILI MCNSVMDPL IYAFRSQEM RKTFKEIIC 
C


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8INRAPeptideMelanocortinMC5Homo sapiensα-MSHCachim(NtGi1-Gs)/β1/γ22.732023-09-20doi.org/10.1038/s41421-023-00586-4
8INR (No Gprot) APeptideMelanocortinMC5Homo sapiensα-MSHCa2.732023-09-20doi.org/10.1038/s41421-023-00586-4
8IODAPeptideMelanocortinMC5Homo sapiensPG-901Cachim(NtGi1-Gs)/β1/γ22.592023-09-20doi.org/10.1038/s41421-023-00586-4
8IOD (No Gprot) APeptideMelanocortinMC5Homo sapiensPG-901Ca2.592023-09-20doi.org/10.1038/s41421-023-00586-4
9K3H (No Gprot) APeptideMelanocortinMC5Homo sapiens--2.862025-08-06doi.org/10.1016/j.str.2025.03.004




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K3H.zip



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