psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I38	R:R:V42	4.61	No	No	0	3	5
2	R:R:I38	R:R:N278	4.25	No	No	0	3	3
3	R:R:I282	R:R:I38	5.89	No	No	0	4	3
4	R:R:A39	R:R:E41	4.53	No	No	0	4	4
5	R:R:F43	R:R:S89	3.96	No	No	0	6	6
6	R:R:F43	R:R:T93	9.08	No	No	0	6	6
7	R:R:F43	R:R:M285	9.95	No	No	0	6	6
8	R:R:I94	R:R:L44	4.28	No	No	0	5	5
9	R:R:L46	R:R:V289	4.47	No	No	0	6	6
10	R:R:G47	R:R:S86	3.71	No	No	0	6	8
11	R:R:I49	R:R:V289	4.61	No	No	0	5	6
12	R:R:N54	R:R:S50	4.47	Yes	No	0	9	8
13	R:R:S50	R:R:S86	6.52	No	No	1	8	8
14	R:R:S288	R:R:S50	6.52	No	No	1	9	8
15	R:R:I55	R:R:L51	5.71	No	No	0	5	6
16	R:R:L51	R:R:M87	11.31	No	No	0	6	5
17	R:R:E53	R:R:V289	4.28	No	No	0	8	6
18	R:R:E53	R:R:P292	4.72	No	No	0	8	9
19	R:R:E53	R:R:L293	3.98	No	No	0	8	6
20	R:R:A79	R:R:N54	4.69	No	Yes	0	9	9
21	R:R:D82	R:R:N54	6.73	Yes	Yes	0	9	9
22	R:R:N54	R:R:P292	6.52	Yes	No	0	9	9
23	R:R:F306	R:R:L56	4.87	No	No	0	6	7
24	R:R:C76	R:R:I58	4.91	No	Yes	0	7	8
25	R:R:I61	R:R:Y72	4.84	No	Yes	3	8	8
26	R:R:I61	R:R:M302	4.37	No	Yes	3	8	8
27	R:R:L67	R:R:N64	6.87	Yes	No	0	9	7
28	R:R:N64	R:R:T305	7.31	No	No	0	7	7
29	R:R:H68	R:R:K65	6.55	No	No	0	8	6
30	R:R:L67	R:R:Y72	10.55	Yes	Yes	3	9	8
31	R:R:E301	R:R:L67	5.3	Yes	Yes	3	7	9
32	R:R:L67	R:R:M302	8.48	Yes	Yes	3	9	8
33	R:R:S69	R:R:Y72	6.36	No	Yes	0	7	8
34	R:R:P70	R:R:Y150	4.17	No	Yes	5	6	8
35	R:R:M154	R:R:P70	5.03	No	No	5	7	6
36	R:R:P70	R:R:S159	7.13	No	No	0	6	7
37	R:R:M71	R:R:Y72	3.59	No	Yes	0	9	8
38	R:R:D139	R:R:M71	5.54	No	No	0	9	9
39	R:R:M71	R:R:R140	6.2	No	Yes	0	9	9
40	R:R:S299	R:R:Y72	7.63	No	Yes	3	8	8
41	R:R:E301	R:R:Y72	4.49	Yes	Yes	3	7	8
42	R:R:M302	R:R:Y72	4.79	Yes	Yes	3	8	8
43	R:R:F73	R:R:S159	7.93	No	No	0	4	7
44	R:R:A135	R:R:F74	8.32	No	Yes	0	7	8
45	R:R:D139	R:R:F74	7.17	No	Yes	0	9	8
46	R:R:F74	R:R:I163	3.77	Yes	No	0	8	8
47	R:R:S132	R:R:S77	6.52	No	No	0	8	9
48	R:R:I163	R:R:S77	4.64	No	No	0	8	9
49	R:R:S77	R:R:W167	4.94	No	Yes	0	9	9
50	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
51	R:R:L78	R:R:S132	4.5	Yes	No	0	9	8
52	R:R:L133	R:R:L78	4.15	No	Yes	1	8	9
53	R:R:D291	R:R:L78	6.79	Yes	Yes	1	9	9
54	R:R:D82	R:R:S129	4.42	Yes	No	0	9	9
55	R:R:D82	R:R:S288	10.31	Yes	No	1	9	9
56	R:R:D291	R:R:D82	6.65	Yes	Yes	1	9	9
57	R:R:L84	R:R:S125	6.01	No	No	0	6	6
58	R:R:S288	R:R:S86	4.89	No	No	1	9	8
59	R:R:I122	R:R:S88	4.64	No	No	0	5	6
60	R:R:I122	R:R:S89	6.19	No	No	0	5	6
61	R:R:E92	R:R:I96	6.83	Yes	No	2	6	4
62	R:R:E92	R:R:F118	18.66	Yes	Yes	0	6	6
63	R:R:D119	R:R:E92	7.8	Yes	Yes	2	4	6
64	L:L:M4	R:R:E92	4.06	No	Yes	2	0	6
65	I:I:?1	R:R:E92	7.31	No	Yes	2	0	6
66	R:R:L99	R:R:T95	4.42	No	No	0	2	4
67	R:R:F118	R:R:T95	5.19	Yes	No	0	6	4
68	R:R:I96	R:R:N100	4.25	No	No	0	4	3
69	L:L:M4	R:R:I96	8.75	No	No	2	0	4
70	R:R:N101	R:R:Y97	6.98	No	No	0	4	4
71	R:R:H103	R:R:L98	3.86	No	No	0	3	4
72	R:R:L99	R:R:V111	5.96	No	No	0	2	3
73	R:R:F110	R:R:I106	5.02	No	No	0	3	5
74	L:L:Y2	R:R:D108	4.6	Yes	No	0	0	2
75	R:R:N116	R:R:R112	4.82	No	No	0	4	3
76	L:L:Y2	R:R:R112	8.23	Yes	No	0	0	3
77	R:R:D115	R:R:N116	6.73	Yes	No	2	8	4
78	R:R:D115	R:R:D119	10.65	Yes	Yes	2	8	4
79	L:L:Y2	R:R:D115	10.34	Yes	Yes	0	0	8
80	L:L:M4	R:R:D115	8.32	No	Yes	2	0	8
81	L:L:R8	R:R:D115	5.96	Yes	Yes	2	0	8
82	I:I:?1	R:R:D115	7.49	No	Yes	2	0	8
83	L:L:R8	R:R:N116	6.03	Yes	No	2	0	4
84	R:R:D119	R:R:I178	4.2	Yes	Yes	2	4	4
85	L:L:F7	R:R:D119	7.17	No	Yes	0	0	4
86	L:L:R8	R:R:D119	20.25	Yes	Yes	2	0	4
87	I:I:?1	R:R:D119	9.98	No	Yes	2	0	4
88	L:L:F7	R:R:I122	20.09	No	No	0	0	5
89	R:R:C123	R:R:G174	3.92	No	No	0	5	6
90	R:R:C123	R:R:F177	4.19	No	Yes	0	5	4
91	R:R:I124	R:R:T171	4.56	No	No	0	4	3
92	R:R:V126	R:R:W251	8.58	No	Yes	0	6	7
93	R:R:C170	R:R:V127	6.83	No	No	0	7	6
94	R:R:A128	R:R:W167	9.08	No	Yes	0	7	9
95	R:R:A128	R:R:C170	3.61	No	No	0	7	7
96	R:R:F194	R:R:M130	4.98	Yes	No	0	7	7
97	R:R:M130	R:R:M197	4.33	No	No	0	7	7
98	R:R:C131	R:R:I166	4.91	No	No	0	5	6
99	R:R:D291	R:R:L133	6.79	Yes	No	1	9	8
100	R:R:L133	R:R:Y295	4.69	No	Yes	1	8	9
101	R:R:L134	R:R:M197	11.31	No	No	0	7	7
102	R:R:L134	R:R:L200	6.92	No	No	0	7	5
103	R:R:I136	R:R:R140	5.01	No	Yes	1	9	9
104	R:R:I136	R:R:Y295	6.04	No	Yes	1	9	9
105	R:R:D139	R:R:Y150	6.9	No	Yes	0	9	8
106	R:R:R140	R:R:Y205	9.26	Yes	No	0	9	9
107	R:R:R140	R:R:Y295	7.2	Yes	Yes	1	9	9
108	R:R:F145	R:R:Y141	18.57	Yes	No	7	7	8
109	R:R:L204	R:R:Y141	7.03	Yes	No	0	7	8
110	R:R:H207	R:R:Y141	7.62	No	No	7	5	8
111	R:R:V142	R:R:Y150	3.79	No	Yes	0	6	8
112	R:R:T143	R:R:Y150	8.74	No	Yes	0	9	8
113	R:R:F145	R:R:I144	7.54	Yes	No	0	7	9
114	R:R:F145	R:R:H207	16.97	Yes	No	7	7	5
115	R:R:F145	R:R:L211	3.65	Yes	No	0	7	5
116	R:R:H152	R:R:R149	10.16	No	No	0	4	5
117	R:R:H151	R:R:Y150	8.71	No	Yes	0	4	8
118	R:R:M154	R:R:Y150	4.79	No	Yes	5	7	8
119	R:R:R158	R:R:T155	3.88	No	No	0	6	8
120	R:R:I166	R:R:W167	4.7	No	Yes	0	6	9
121	R:R:C173	R:R:F169	8.38	No	No	0	4	4
122	R:R:C173	R:R:F177	4.19	No	Yes	0	4	4
123	R:R:F177	R:R:V186	7.87	Yes	No	0	4	4
124	R:R:F177	R:R:L190	4.87	Yes	No	0	4	5
125	L:L:R8	R:R:I178	16.28	Yes	Yes	2	0	4
126	L:L:W9	R:R:I178	4.7	Yes	Yes	2	0	4
127	R:R:E182	R:R:S181	5.75	No	No	0	4	2
128	L:L:R8	R:R:S181	10.54	Yes	No	2	0	2
129	L:L:W9	R:R:S181	4.94	Yes	No	2	0	2
130	R:R:S183	R:R:Y185	6.36	No	No	0	4	1
131	R:R:I187	R:R:L258	5.71	No	No	0	5	4
132	R:R:I187	R:R:L262	5.71	No	No	0	5	3
133	L:L:W9	R:R:I187	5.87	Yes	No	0	0	5
134	R:R:L188	R:R:L262	4.15	No	No	8	4	3
135	R:R:F255	R:R:L190	3.65	No	No	0	5	5
136	L:L:W9	R:R:L190	6.83	Yes	No	0	0	5
137	R:R:F195	R:R:I191	3.77	No	No	0	4	4
138	R:R:I191	R:R:T259	4.56	No	No	0	4	4
139	R:R:F194	R:R:F195	7.5	Yes	No	0	7	4
140	R:R:F194	R:R:L198	3.65	Yes	No	6	7	6
141	R:R:F194	R:R:F247	5.36	Yes	Yes	6	7	8
142	R:R:F194	R:R:F255	23.58	Yes	No	0	7	5
143	R:R:F247	R:R:L198	4.87	Yes	No	6	8	6
144	R:R:L200	R:R:L204	4.15	No	Yes	0	5	7
145	R:R:L201	R:R:Y205	4.69	No	No	0	8	9
146	R:R:F247	R:R:L201	8.53	Yes	No	0	8	8
147	R:R:L244	R:R:V202	4.47	Yes	No	0	7	5
148	R:R:L243	R:R:Y205	5.86	Yes	No	0	8	9
149	R:R:F209	R:R:R213	7.48	Yes	No	0	6	5
150	R:R:F209	R:R:V240	3.93	Yes	No	0	6	8
151	R:R:H215	R:R:L211	3.86	No	No	0	7	5
152	R:R:K217	R:R:R213	3.71	No	No	0	5	5
153	R:R:R213	R:R:S233	6.59	No	No	0	5	6
154	R:R:H215	R:R:T214	5.48	No	No	0	7	5
155	R:R:H215	R:R:R218	4.51	No	No	0	7	5
156	R:R:R231	R:R:V216	3.92	No	No	0	4	6
157	R:R:A220	R:R:R231	6.91	No	No	0	4	4
158	R:R:I294	R:R:L243	4.28	Yes	Yes	1	9	8
159	R:R:L243	R:R:Y295	8.21	Yes	Yes	1	8	9
160	R:R:M290	R:R:V246	9.13	No	No	0	6	6
161	R:R:F247	R:R:W251	5.01	Yes	Yes	0	8	7
162	R:R:C250	R:R:N287	6.3	No	No	0	8	9
163	R:R:I284	R:R:W251	11.74	No	Yes	0	7	7
164	R:R:N287	R:R:W251	16.95	No	Yes	0	9	7
165	R:R:P253	R:R:Y280	6.95	No	Yes	0	9	5
166	R:R:L283	R:R:P253	4.93	No	No	0	7	9
167	R:R:F254	R:R:F255	8.57	Yes	No	0	5	5
168	R:R:F254	R:R:L258	6.09	Yes	No	0	5	4
169	R:R:F254	R:R:F277	5.36	Yes	Yes	0	5	4
170	R:R:F254	R:R:I284	6.28	Yes	No	0	5	7
171	R:R:F273	R:R:L256	3.65	No	No	0	4	4
172	R:R:H257	R:R:M261	3.94	Yes	No	0	4	4
173	R:R:H257	R:R:M274	11.82	Yes	No	0	4	1
174	R:R:F277	R:R:H257	14.71	Yes	Yes	0	4	4
175	R:R:H257	R:R:Y280	6.53	Yes	Yes	0	4	5
176	R:R:L260	R:R:S263	4.5	Yes	No	4	3	4
177	R:R:C264	R:R:L260	4.76	Yes	Yes	4	3	3
178	R:R:C270	R:R:L260	4.76	No	Yes	4	2	3
179	R:R:F273	R:R:L260	3.65	No	Yes	0	4	3
180	R:R:C264	R:R:S263	5.16	Yes	No	4	3	4
181	R:R:C264	R:R:C270	7.28	Yes	No	4	3	2
182	R:R:P265	R:R:Q266	11.05	No	No	0	2	1
183	R:R:F273	R:R:Y280	15.47	No	Yes	0	4	5
184	R:R:H276	R:R:Y280	7.62	No	Yes	0	3	5
185	R:R:F277	R:R:L281	6.09	Yes	No	0	4	3
186	L:L:G10	R:R:F277	9.03	No	Yes	0	0	4
187	L:L:H6	R:R:N278	12.75	No	No	0	0	3
188	R:R:D291	R:R:N287	10.77	Yes	No	0	9	9
189	R:R:I294	R:R:Y295	7.25	Yes	Yes	1	9	9
190	R:R:F297	R:R:F306	17.15	No	No	0	6	6
191	R:R:E301	R:R:S299	5.75	Yes	No	3	7	8
192	R:R:Q300	R:R:R303	5.84	No	No	0	5	9
193	R:R:F306	R:R:M302	7.46	No	Yes	0	6	8
194	R:R:E308	R:R:K304	4.05	No	No	0	5	5
195	L:L:E5	L:L:K11	5.4	No	No	0	0	0
196	L:L:F7	L:L:W9	7.02	No	Yes	0	0	0
197	L:L:R8	L:L:W9	14.99	Yes	Yes	2	0	0
198	L:L:K11	L:L:P12	5.02	No	No	0	0	0
199	R:R:A79	R:R:V57	3.39	No	No	0	9	9
200	R:R:A296	R:R:V57	3.39	No	No	0	8	9
201	R:R:F73	R:R:H68	3.39	No	No	0	4	8
202	R:R:F110	R:R:H113	3.39	No	No	0	3	4
203	R:R:A60	R:R:T305	3.36	No	No	0	8	7
204	R:R:L222	R:R:P223	3.28	No	No	0	3	2
205	R:R:A79	R:R:I58	3.25	No	Yes	0	9	8
206	R:R:S125	R:R:V85	3.23	No	No	0	6	8
207	R:R:S183	R:R:V186	3.23	No	No	0	4	4
208	R:R:S233	R:R:V216	3.23	No	No	0	6	6
209	R:R:T93	R:R:V40	3.17	No	No	0	6	4
210	R:R:C286	R:R:L46	3.17	No	No	0	5	6
211	L:L:P12	R:R:Q266	3.16	No	No	0	0	1
212	R:R:A137	R:R:L204	3.15	No	Yes	0	9	7
213	R:R:C264	R:R:N267	3.15	Yes	No	0	3	3
214	R:R:I58	R:R:V80	3.07	Yes	No	0	8	5
215	R:R:I61	R:R:V75	3.07	No	No	0	8	8
216	R:R:I136	R:R:V75	3.07	No	No	0	9	8
217	R:R:I153	R:R:V142	3.07	No	No	0	6	6
218	R:R:I294	R:R:V246	3.07	Yes	No	0	9	6
219	R:R:M274	R:R:S271	3.07	No	No	0	1	1
220	R:R:F209	R:R:G236	3.01	Yes	No	0	6	8
221	R:R:L204	R:R:V138	2.98	Yes	No	0	7	7
222	R:R:L244	R:R:V240	2.98	Yes	No	0	7	8
223	R:R:L188	R:R:T184	2.95	No	No	8	4	3
224	R:R:L262	R:R:T184	2.95	No	No	8	3	3
225	R:R:L243	R:R:T239	2.95	Yes	No	0	8	9
226	R:R:A109	R:R:H113	2.93	No	No	0	2	4
227	R:R:I144	R:R:M208	2.92	No	No	0	9	9
228	R:R:I294	R:R:M242	2.92	Yes	No	0	9	6
229	R:R:Q235	R:R:V238	2.87	No	No	0	8	6
230	R:R:I106	R:R:L104	2.85	No	No	0	5	5
231	R:R:I206	R:R:L210	2.85	No	No	0	4	3
232	R:R:I219	R:R:L222	2.85	No	No	0	5	3
233	R:R:L51	R:R:M83	2.83	No	No	0	6	7
234	R:R:C189	R:R:F177	2.79	No	Yes	0	4	4
235	R:R:H276	R:R:S275	2.79	No	No	0	3	2
236	R:R:A252	R:R:F194	2.77	No	Yes	0	5	7
237	R:R:L201	R:R:L244	2.77	No	Yes	0	8	7
238	L:L:H6	R:R:T93	2.74	No	No	0	0	6
239	R:R:N64	R:R:N66	2.72	No	No	0	7	6
240	R:R:H276	R:R:M279	2.63	No	No	0	3	4
241	R:R:F177	R:R:V176	2.62	Yes	No	0	4	5
242	R:R:A81	R:R:W167	2.59	No	Yes	0	8	9
243	R:R:H103	R:R:N101	2.55	No	No	0	3	4
244	R:R:F74	R:R:I162	2.51	Yes	No	0	8	6
245	R:R:F118	R:R:I114	2.51	Yes	No	0	6	4
246	R:R:F118	R:R:M121	2.49	Yes	No	0	6	5
247	R:R:F177	R:R:M193	2.49	Yes	No	0	4	4
248	R:R:M242	R:R:R298	2.48	No	No	0	6	8
249	R:R:F209	R:R:L210	2.44	Yes	No	0	6	3
250	R:R:I153	R:R:Y146	2.42	No	No	0	6	6
251	R:R:I124	R:R:W167	2.35	No	Yes	0	4	9
252	R:R:L179	R:R:Y180	2.34	No	No	0	3	3
253	R:R:M87	R:R:W91	2.33	No	No	0	5	7
254	R:R:L84	R:R:W167	2.28	No	Yes	0	6	9
255	R:R:R272	R:R:Y269	2.06	No	No	0	4	4
256	R:R:F118	R:R:W91	2	Yes	No	0	6	7
257	R:R:A164	R:R:G165	1.95	No	No	0	4	4
258	R:R:C264	R:R:P265	1.88	Yes	No	0	3	2
259	R:R:G160	R:R:S159	1.86	No	No	0	1	7
260	R:R:G172	R:R:T171	1.82	No	No	0	3	3
261	R:R:G245	R:R:T248	1.82	No	No	0	5	5
262	R:R:G59	R:R:K63	1.74	No	No	0	4	5
263	R:R:G245	R:R:L244	1.71	No	Yes	0	5	7
264	R:R:A39	R:R:V42	1.7	No	No	0	4	5
265	R:R:G236	R:R:Q235	1.64	No	No	0	8	8
266	R:R:C311	R:R:I310	1.64	No	No	0	6	5
267	R:R:A90	R:R:L44	1.58	No	No	0	6	5
268	R:R:I124	R:R:S120	1.55	No	No	0	4	5
269	R:R:I175	R:R:S120	1.55	No	No	0	3	5
270	R:R:I178	R:R:S120	1.55	Yes	No	0	4	5
271	R:R:I58	R:R:V62	1.54	Yes	No	0	8	3
272	R:R:I49	R:R:T45	1.52	No	No	0	5	3
273	R:R:M121	R:R:V117	1.52	No	No	0	5	4
274	R:R:I309	R:R:T305	1.52	No	No	0	7	7
275	R:R:M234	R:R:T232	1.51	No	No	0	5	5
276	R:R:L200	R:R:S203	1.5	No	No	0	5	4
277	R:R:L44	R:R:V40	1.49	No	No	0	5	4
278	R:R:L52	R:R:V48	1.49	No	No	0	5	5
279	L:L:S3	R:R:N100	1.49	No	No	0	0	3
280	R:R:I309	R:R:K63	1.45	No	No	0	7	5
281	R:R:I94	R:R:L98	1.43	No	No	0	5	4
282	R:R:I175	R:R:L179	1.43	No	No	0	3	3
283	R:R:Q235	R:R:T232	1.42	No	No	0	8	5
284	R:R:A156	R:R:F73	1.39	No	No	0	2	4
285	R:R:A237	R:R:F209	1.39	No	Yes	0	7	6
286	R:R:L104	R:R:L98	1.38	No	No	0	5	4
287	R:R:L104	R:R:L99	1.38	No	No	0	5	2
288	R:R:R157	R:R:T155	1.29	No	No	0	4	8
289	R:R:E301	R:R:Q300	1.27	Yes	No	0	7	5
290	L:L:S1	L:L:Y2	1.27	No	Yes	0	0	0
291	R:R:I219	R:R:R231	1.25	No	No	0	5	4
292	R:R:M154	R:R:R158	1.24	No	No	0	7	6
293	R:R:L268	R:R:R272	1.21	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N54	5.6025	4	0	9
2	R:R:I58	3.1925	4	0	8
3	R:R:L67	7.8	4	3	9
4	R:R:Y72	6.03571	7	3	8
5	R:R:F74	5.4425	4	0	8
6	R:R:L78	5.895	4	1	9
7	R:R:D82	7.25	5	1	9
8	R:R:E92	8.932	5	2	6
9	R:R:D115	8.24833	6	2	8
10	R:R:F118	6.17	5	0	6
11	R:R:D119	10.0083	6	2	4
12	R:R:R140	6.9175	4	1	9
13	R:R:F145	11.6825	4	7	7
14	R:R:Y150	6.18333	6	5	8
15	R:R:W167	4.32333	6	0	9
16	R:R:F177	4.14571	7	0	4
17	R:R:I178	6.6825	4	2	4
18	R:R:F194	7.97333	6	6	7
19	R:R:L204	4.3275	4	0	7
20	R:R:F209	3.65	5	0	6
21	R:R:L243	5.325	4	1	8
22	R:R:L244	2.9825	4	0	7
23	R:R:F247	5.9425	4	6	8
24	R:R:W251	10.57	4	0	7
25	R:R:F254	6.575	4	0	5
26	R:R:H257	9.25	4	0	4
27	R:R:L260	4.4175	4	4	3
28	R:R:C264	4.446	5	4	3
29	R:R:F277	8.7975	4	0	4
30	R:R:Y280	9.1425	4	0	5
31	R:R:D291	7.75	4	1	9
32	R:R:I294	4.38	4	1	9
33	R:R:Y295	6.678	5	1	9
34	R:R:E301	4.2025	4	3	7
35	R:R:M302	6.275	4	3	8
36	L:L:Y2	6.11	4	0	0
37	L:L:R8	12.3417	6	2	0
38	L:L:W9	7.39167	6	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F43	R:R:T93	29.1121	9.08	No	No	0	6	6
2	L:L:H6	R:R:T93	18.5169	2.74	No	No	0	0	6
3	L:L:H6	R:R:N278	15.899	12.75	No	No	0	0	3
4	R:R:I38	R:R:N278	13.3613	4.25	No	No	0	3	3
5	R:R:F43	R:R:S89	33.9281	3.96	No	No	0	6	6
6	R:R:I122	R:R:S89	36.3423	6.19	No	No	0	5	6
7	L:L:F7	R:R:I122	41.1768	20.09	No	No	0	0	5
8	L:L:F7	R:R:D119	33.6318	7.17	No	Yes	0	0	4
9	R:R:D119	R:R:I178	50.7471	4.2	Yes	Yes	2	4	4
10	R:R:I178	R:R:S120	52.5624	1.55	Yes	No	0	4	5
11	R:R:I124	R:R:S120	49.7962	1.55	No	No	0	4	5
12	R:R:I124	R:R:W167	47.8143	2.35	No	Yes	0	4	9
13	R:R:S77	R:R:W167	48.1847	4.94	No	Yes	0	9	9
14	R:R:S132	R:R:S77	29.7049	6.52	No	No	0	8	9
15	R:R:L78	R:R:S132	29.9271	4.5	Yes	No	0	9	8
16	R:R:D82	R:R:L78	25.5557	8.14	Yes	Yes	1	9	9
17	R:R:D82	R:R:N54	43.023	6.73	Yes	Yes	0	9	9
18	R:R:N54	R:R:P292	20.8385	6.52	Yes	No	0	9	9
19	R:R:E53	R:R:P292	18.2761	4.72	No	No	0	8	9
20	R:R:E53	R:R:V289	13.1143	4.28	No	No	0	8	6
21	L:L:F7	L:L:W9	57.6871	7.02	No	Yes	0	0	0
22	L:L:W9	R:R:I178	45.1531	4.7	Yes	Yes	2	0	4
23	L:L:W9	R:R:I187	34.9099	5.87	Yes	No	0	0	5
24	R:R:I187	R:R:L258	33.8232	5.71	No	No	0	5	4
25	R:R:F254	R:R:L258	34.4406	6.09	Yes	No	0	5	4
26	R:R:F254	R:R:I284	39.1887	6.28	Yes	No	0	5	7
27	R:R:I284	R:R:W251	38.2378	11.74	No	Yes	0	7	7
28	R:R:N287	R:R:W251	37.7686	16.95	No	Yes	0	9	7
29	R:R:D291	R:R:N287	33.4218	10.77	Yes	No	0	9	9
30	R:R:D291	R:R:D82	32.2302	6.65	Yes	Yes	1	9	9
31	L:L:W9	R:R:L190	96.4683	6.83	Yes	No	0	0	5
32	R:R:F255	R:R:L190	100	3.65	No	No	0	5	5
33	R:R:F254	R:R:F255	51.4078	8.57	Yes	No	0	5	5
34	R:R:F194	R:R:F255	86.6757	23.58	Yes	No	0	7	5
35	R:R:F194	R:R:F247	76.6732	5.36	Yes	Yes	6	7	8
36	R:R:F247	R:R:W251	35.1877	5.01	Yes	Yes	0	8	7
37	R:R:D82	R:R:S288	10.1939	10.31	Yes	No	1	9	9
38	R:R:D119	R:R:E92	85.731	7.8	Yes	Yes	2	4	6
39	R:R:E92	R:R:F118	74.5369	18.66	Yes	Yes	0	6	6
40	R:R:F118	R:R:W91	18.3564	2	Yes	No	0	6	7
41	R:R:M87	R:R:W91	14.7135	2.33	No	No	0	5	7
42	R:R:L51	R:R:M87	11.0521	11.31	No	No	0	6	5
43	R:R:A79	R:R:N54	18.2761	4.69	No	Yes	0	9	9
44	R:R:M71	R:R:Y72	35.9657	3.59	No	Yes	0	9	8
45	R:R:M71	R:R:R140	52.0005	6.2	No	Yes	0	9	9
46	R:R:R140	R:R:Y205	46.0361	9.26	Yes	No	0	9	9
47	R:R:L201	R:R:Y205	59.5147	4.69	No	No	0	8	9
48	R:R:F247	R:R:L201	84.8049	8.53	Yes	No	0	8	8
49	R:R:A79	R:R:I58	10.5149	3.25	No	Yes	0	9	8
50	R:R:L67	R:R:Y72	15.5532	10.55	Yes	Yes	3	9	8
51	R:R:L67	R:R:N64	14.1269	6.87	Yes	No	0	9	7
52	R:R:N64	R:R:T305	10.1507	7.31	No	No	0	7	7
53	R:R:P70	R:R:S159	12.9229	7.13	No	No	0	6	7
54	R:R:P70	R:R:Y150	14.8617	4.17	No	Yes	5	6	8
55	R:R:D139	R:R:Y150	35.4717	6.9	No	Yes	0	9	8
56	R:R:D139	R:R:F74	27.2783	7.17	No	Yes	0	9	8
57	R:R:F74	R:R:I163	27.6118	3.77	Yes	No	0	8	8
58	R:R:I163	R:R:S77	28.2539	4.64	No	No	0	8	9
59	R:R:L133	R:R:L78	15.9422	4.15	No	Yes	1	8	9
60	R:R:D291	R:R:L133	11.7375	6.79	Yes	No	1	9	8
61	R:R:E92	R:R:I96	10.6076	6.83	Yes	No	2	6	4
62	R:R:L104	R:R:L98	16.041	1.38	No	No	0	5	4
63	R:R:L104	R:R:L99	33.2366	1.38	No	No	0	5	2
64	R:R:L99	R:R:T95	40.0531	4.42	No	No	0	2	4
65	R:R:H103	R:R:L98	11.0521	3.86	No	No	0	3	4
66	R:R:F110	R:R:I106	11.0521	5.02	No	No	0	3	5
67	R:R:I106	R:R:L104	14.7135	2.85	No	No	0	5	5
68	L:L:R8	R:R:D119	24.9815	20.25	Yes	Yes	2	0	4
69	L:L:R8	L:L:W9	36.0706	14.99	Yes	Yes	2	0	0
70	R:R:F177	R:R:L190	22.4994	4.87	Yes	No	0	4	5
71	R:R:F194	R:R:M130	31.6189	4.98	Yes	No	0	7	7
72	R:R:M130	R:R:M197	29.853	4.33	No	No	0	7	7
73	R:R:R140	R:R:Y295	17.3191	7.2	Yes	Yes	1	9	9
74	R:R:L243	R:R:Y205	14.1763	5.86	Yes	No	0	8	9
75	R:R:L134	R:R:M197	28.0748	11.31	No	No	0	7	7
76	R:R:L134	R:R:L200	26.2843	6.92	No	No	0	7	5
77	R:R:F145	R:R:Y141	13.3613	18.57	Yes	No	7	7	8
78	R:R:L204	R:R:Y141	17.1462	7.03	Yes	No	0	7	8
79	R:R:L200	R:R:L204	22.6661	4.15	No	Yes	0	5	7
80	R:R:L201	R:R:L244	51.346	2.77	No	Yes	0	8	7
81	R:R:F209	R:R:V240	40.6952	3.93	Yes	No	0	6	8
82	R:R:L244	R:R:V240	42.8501	2.98	Yes	No	0	7	8
83	R:R:F209	R:R:R213	20.8323	7.48	Yes	No	0	6	5
84	R:R:R213	R:R:S233	16.2571	6.59	No	No	0	5	6
85	R:R:S233	R:R:V216	14.0652	3.23	No	No	0	6	6
86	R:R:R231	R:R:V216	11.756	3.92	No	No	0	4	6
87	R:R:F254	R:R:F277	78.0748	5.36	Yes	Yes	0	5	4
88	R:R:F277	R:R:H257	69.2517	14.71	Yes	Yes	0	4	4
89	R:R:H257	R:R:Y280	57.0758	6.53	Yes	Yes	0	4	5
90	R:R:F273	R:R:Y280	38.4416	15.47	No	Yes	0	4	5
91	R:R:F273	R:R:L260	32.1314	3.65	No	Yes	0	4	3
92	R:R:C264	R:R:L260	22.487	4.76	Yes	Yes	4	3	3
93	R:R:C264	R:R:P265	16.1398	1.88	Yes	No	0	3	2
94	R:R:P265	R:R:Q266	12.9044	11.05	No	No	0	2	1
95	R:R:F209	R:R:G236	11.6449	3.01	Yes	No	0	6	8
96	R:R:F118	R:R:T95	43.4613	5.19	Yes	No	0	6	4
97	R:R:D139	R:R:M71	35.2494	5.54	No	No	0	9	9
98	R:R:L133	R:R:Y295	26.4942	4.69	No	Yes	1	8	9
99	L:L:R8	R:R:D115	11.6449	5.96	Yes	Yes	2	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I38	R:R:N278	4.25	0	No	No	3	3	2	1
R:R:F43	R:R:S89	3.96	0	No	No	6	6	2	2
R:R:F43	R:R:T93	9.08	0	No	No	6	6	2	1
R:R:I122	R:R:S88	4.64	0	No	No	5	6	1	2
R:R:I122	R:R:S89	6.19	0	No	No	5	6	1	2
R:R:E92	R:R:I96	6.83	2	Yes	No	6	4	1	1
R:R:E92	R:R:F118	18.66	2	Yes	Yes	6	6	1	2
R:R:D119	R:R:E92	7.8	2	Yes	Yes	4	6	1	1
L:L:M4	R:R:E92	4.06	2	No	Yes	0	6	0	1
I:I:?1	R:R:E92	7.31	2	No	Yes	0	6	2	1
R:R:I96	R:R:N100	4.25	2	No	No	4	3	1	1
L:L:M4	R:R:I96	8.75	2	No	No	0	4	0	1
L:L:Y2	R:R:D108	4.6	0	Yes	No	0	2	0	1
R:R:N116	R:R:R112	4.82	2	No	No	4	3	1	1
L:L:Y2	R:R:R112	8.23	0	Yes	No	0	3	0	1
R:R:D115	R:R:N116	6.73	2	Yes	No	8	4	1	1
R:R:D115	R:R:D119	10.65	2	Yes	Yes	8	4	1	1
L:L:Y2	R:R:D115	10.34	0	Yes	Yes	0	8	0	1
L:L:M4	R:R:D115	8.32	2	No	Yes	0	8	0	1
L:L:R8	R:R:D115	5.96	2	Yes	Yes	0	8	0	1
I:I:?1	R:R:D115	7.49	2	No	Yes	0	8	2	1
L:L:R8	R:R:N116	6.03	2	Yes	No	0	4	0	1
R:R:D119	R:R:I178	4.2	2	Yes	Yes	4	4	1	1
L:L:F7	R:R:D119	7.17	0	No	Yes	0	4	0	1
L:L:R8	R:R:D119	20.25	2	Yes	Yes	0	4	0	1
I:I:?1	R:R:D119	9.98	2	No	Yes	0	4	2	1
L:L:F7	R:R:I122	20.09	0	No	No	0	5	0	1
R:R:F177	R:R:L190	4.87	0	Yes	No	4	5	2	1
L:L:R8	R:R:I178	16.28	2	Yes	Yes	0	4	0	1
L:L:W9	R:R:I178	4.7	2	Yes	Yes	0	4	0	1
R:R:E182	R:R:S181	5.75	0	No	No	4	2	2	1
L:L:R8	R:R:S181	10.54	2	Yes	No	0	2	0	1
L:L:W9	R:R:S181	4.94	2	Yes	No	0	2	0	1
R:R:I187	R:R:L258	5.71	0	No	No	5	4	1	2
R:R:I187	R:R:L262	5.71	0	No	No	5	3	1	2
L:L:W9	R:R:I187	5.87	2	Yes	No	0	5	0	1
R:R:F255	R:R:L190	3.65	0	No	No	5	5	2	1
L:L:W9	R:R:L190	6.83	2	Yes	No	0	5	0	1
R:R:F254	R:R:F255	8.57	0	Yes	No	5	5	2	2
R:R:F254	R:R:L258	6.09	0	Yes	No	5	4	2	2
R:R:F254	R:R:F277	5.36	0	Yes	Yes	5	4	2	1
R:R:F277	R:R:H257	14.71	0	Yes	Yes	4	4	1	2
R:R:P265	R:R:Q266	11.05	0	No	No	2	1	2	1
R:R:F277	R:R:L281	6.09	0	Yes	No	4	3	1	2
L:L:G10	R:R:F277	9.03	0	No	Yes	0	4	0	1
L:L:H6	R:R:N278	12.75	0	No	No	0	3	0	1
R:R:T93	R:R:V40	3.17	0	No	No	6	4	1	2
L:L:P12	R:R:Q266	3.16	0	No	No	0	1	0	1
L:L:H6	R:R:T93	2.74	0	No	No	0	6	0	1
R:R:I178	R:R:S120	1.55	2	Yes	No	4	5	1	2
L:L:S3	R:R:N100	1.49	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8INR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	265
Number of Links	293
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	53197
Length Of Smallest Path	3
Average Path Length	13.1125
Length of Longest Path	27
Minimum Path Strength	1.38
Average Path Strength	6.80396
Maximum Path Strength	17.62
Minimum Path Correlation	0.7
Average Path Correlation	0.936582
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	54.1393
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1744
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • cellular component organization • membrane fusion • fusion of virus membrane with host plasma membrane • cellular process • cellular component organization or biogenesis • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • localization • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • metabolic process • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • membrane • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide signaling pathway • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of localization • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • cell-cell signaling • endocrine process • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • membrane-bounded organelle • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • D2 dopamine receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • amide transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • nucleus • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P33032
Sequence	>8INR_nogp_Chain_R I A V E V F L T L G V I S L L E N I L V I G A I V K N K N L H S P M Y F F V C S L A V A D M L V S M S S A W E T I T I Y L L N N K H L V I A D A F V R H I D N V F D S M I C I S V V A S M C S L L A I A V D R Y V T I F Y A L R Y H H I M T A R R S G A I I A G I W A F C T G C G I V F I L Y S E S T Y V I L C L I S M F F A M L F L L V S L Y I H M F L L A R T H V K R I A A L P G A S R T S M Q G A V T V T M L L G V F T V C W A P F F L H L T L M L S C P Q N L Y C S R F M S H F N M Y L I L I M C N S V M D P L I Y A F R S Q E M R K T F K E I I C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOD	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca	chim(NtGi1-Gs)/β1/γ2	2.59	2023-09-20	10.1038/s41421-023-00586-4
	8IOD (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca		2.59	2023-09-20	10.1038/s41421-023-00586-4
	8INR	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.73	2023-09-20	10.1038/s41421-023-00586-4
	8INR (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca		2.73	2023-09-20	10.1038/s41421-023-00586-4

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Download 8INR_nogp.zip

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