psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I38	R:R:V42	4.61	No	No	0	3	5
2	R:R:I38	R:R:N278	4.25	No	No	0	3	3
3	R:R:I282	R:R:I38	5.89	No	No	0	4	3
4	R:R:A39	R:R:E41	4.53	No	No	0	4	4
5	R:R:F43	R:R:S89	3.96	No	No	0	6	6
6	R:R:F43	R:R:T93	9.08	No	No	0	6	6
7	R:R:F43	R:R:M285	9.95	No	No	0	6	6
8	R:R:I94	R:R:L44	4.28	No	No	0	5	5
9	R:R:L46	R:R:V289	4.47	No	No	0	6	6
10	R:R:G47	R:R:S86	3.71	No	No	0	6	8
11	R:R:I49	R:R:V289	4.61	No	No	0	5	6
12	R:R:N54	R:R:S50	4.47	Yes	No	0	9	8
13	R:R:S50	R:R:S86	6.52	No	No	1	8	8
14	R:R:S288	R:R:S50	6.52	No	No	1	9	8
15	R:R:I55	R:R:L51	5.71	No	No	0	5	6
16	R:R:L51	R:R:M87	11.31	No	No	0	6	5
17	R:R:E53	R:R:V289	4.28	No	No	0	8	6
18	R:R:E53	R:R:P292	4.72	No	No	0	8	9
19	R:R:E53	R:R:L293	3.98	No	No	0	8	6
20	R:R:A79	R:R:N54	4.69	No	Yes	0	9	9
21	R:R:D82	R:R:N54	6.73	Yes	Yes	0	9	9
22	R:R:N54	R:R:P292	6.52	Yes	No	0	9	9
23	R:R:F306	R:R:L56	4.87	No	No	0	6	7
24	R:R:C76	R:R:I58	4.91	No	Yes	0	7	8
25	R:R:I61	R:R:Y72	4.84	No	Yes	3	8	8
26	R:R:I61	R:R:M302	4.37	No	Yes	3	8	8
27	R:R:L67	R:R:N64	6.87	Yes	No	0	9	7
28	R:R:N64	R:R:T305	7.31	No	No	0	7	7
29	R:R:H68	R:R:K65	6.55	No	No	0	8	6
30	R:R:L67	R:R:Y72	10.55	Yes	Yes	3	9	8
31	R:R:E301	R:R:L67	5.3	Yes	Yes	3	7	9
32	R:R:L67	R:R:M302	8.48	Yes	Yes	3	9	8
33	R:R:S69	R:R:Y72	6.36	No	Yes	0	7	8
34	R:R:P70	R:R:Y150	4.17	No	Yes	5	6	8
35	R:R:M154	R:R:P70	5.03	No	No	5	7	6
36	R:R:P70	R:R:S159	7.13	No	No	0	6	7
37	R:R:M71	R:R:Y72	3.59	No	Yes	0	9	8
38	R:R:D139	R:R:M71	5.54	No	No	0	9	9
39	R:R:M71	R:R:R140	6.2	No	Yes	0	9	9
40	R:R:S299	R:R:Y72	7.63	No	Yes	3	8	8
41	R:R:E301	R:R:Y72	4.49	Yes	Yes	3	7	8
42	R:R:M302	R:R:Y72	4.79	Yes	Yes	3	8	8
43	R:R:F73	R:R:S159	7.93	No	No	0	4	7
44	R:R:A135	R:R:F74	8.32	No	Yes	0	7	8
45	R:R:D139	R:R:F74	7.17	No	Yes	0	9	8
46	R:R:F74	R:R:I163	3.77	Yes	No	0	8	8
47	R:R:S132	R:R:S77	6.52	No	No	0	8	9
48	R:R:I163	R:R:S77	4.64	No	No	0	8	9
49	R:R:S77	R:R:W167	4.94	No	Yes	0	9	9
50	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
51	R:R:L78	R:R:S132	4.5	Yes	No	0	9	8
52	R:R:L133	R:R:L78	4.15	No	Yes	1	8	9
53	R:R:D291	R:R:L78	6.79	Yes	Yes	1	9	9
54	R:R:D82	R:R:S129	4.42	Yes	No	0	9	9
55	R:R:D82	R:R:S288	10.31	Yes	No	1	9	9
56	R:R:D291	R:R:D82	6.65	Yes	Yes	1	9	9
57	R:R:L84	R:R:S125	6.01	No	No	0	6	6
58	R:R:S288	R:R:S86	4.89	No	No	1	9	8
59	R:R:I122	R:R:S88	4.64	No	No	0	5	6
60	R:R:I122	R:R:S89	6.19	No	No	0	5	6
61	R:R:E92	R:R:I96	6.83	Yes	No	2	6	4
62	R:R:E92	R:R:F118	18.66	Yes	Yes	0	6	6
63	R:R:D119	R:R:E92	7.8	Yes	Yes	2	4	6
64	L:L:M4	R:R:E92	4.06	No	Yes	2	0	6
65	I:I:?1	R:R:E92	7.31	No	Yes	2	0	6
66	R:R:L99	R:R:T95	4.42	No	No	0	2	4
67	R:R:F118	R:R:T95	5.19	Yes	No	0	6	4
68	R:R:I96	R:R:N100	4.25	No	No	0	4	3
69	L:L:M4	R:R:I96	8.75	No	No	2	0	4
70	R:R:N101	R:R:Y97	6.98	No	No	0	4	4
71	R:R:H103	R:R:L98	3.86	No	No	0	3	4
72	R:R:L99	R:R:V111	5.96	No	No	0	2	3
73	R:R:F110	R:R:I106	5.02	No	No	0	3	5
74	L:L:Y2	R:R:D108	4.6	Yes	No	0	0	2
75	R:R:N116	R:R:R112	4.82	No	No	0	4	3
76	L:L:Y2	R:R:R112	8.23	Yes	No	0	0	3
77	R:R:D115	R:R:N116	6.73	Yes	No	2	8	4
78	R:R:D115	R:R:D119	10.65	Yes	Yes	2	8	4
79	L:L:Y2	R:R:D115	10.34	Yes	Yes	0	0	8
80	L:L:M4	R:R:D115	8.32	No	Yes	2	0	8
81	L:L:R8	R:R:D115	5.96	Yes	Yes	2	0	8
82	I:I:?1	R:R:D115	7.49	No	Yes	2	0	8
83	L:L:R8	R:R:N116	6.03	Yes	No	2	0	4
84	R:R:D119	R:R:I178	4.2	Yes	Yes	2	4	4
85	L:L:F7	R:R:D119	7.17	No	Yes	0	0	4
86	L:L:R8	R:R:D119	20.25	Yes	Yes	2	0	4
87	I:I:?1	R:R:D119	9.98	No	Yes	2	0	4
88	L:L:F7	R:R:I122	20.09	No	No	0	0	5
89	R:R:C123	R:R:G174	3.92	No	No	0	5	6
90	R:R:C123	R:R:F177	4.19	No	Yes	0	5	4
91	R:R:I124	R:R:T171	4.56	No	No	0	4	3
92	R:R:V126	R:R:W251	8.58	No	Yes	0	6	7
93	R:R:C170	R:R:V127	6.83	No	No	0	7	6
94	R:R:A128	R:R:W167	9.08	No	Yes	0	7	9
95	R:R:A128	R:R:C170	3.61	No	No	0	7	7
96	R:R:F194	R:R:M130	4.98	Yes	No	0	7	7
97	R:R:M130	R:R:M197	4.33	No	No	0	7	7
98	R:R:C131	R:R:I166	4.91	No	No	0	5	6
99	R:R:D291	R:R:L133	6.79	Yes	No	1	9	8
100	R:R:L133	R:R:Y295	4.69	No	Yes	1	8	9
101	R:R:L134	R:R:M197	11.31	No	No	0	7	7
102	R:R:L134	R:R:L200	6.92	No	No	0	7	5
103	R:R:I136	R:R:R140	5.01	No	Yes	1	9	9
104	R:R:I136	R:R:Y295	6.04	No	Yes	1	9	9
105	R:R:D139	R:R:Y150	6.9	No	Yes	0	9	8
106	R:R:R140	R:R:Y205	9.26	Yes	No	0	9	9
107	R:R:R140	R:R:Y295	7.2	Yes	Yes	1	9	9
108	R:R:F145	R:R:Y141	18.57	Yes	No	7	7	8
109	R:R:L204	R:R:Y141	7.03	Yes	No	0	7	8
110	R:R:H207	R:R:Y141	7.62	No	No	7	5	8
111	R:R:V142	R:R:Y150	3.79	No	Yes	0	6	8
112	R:R:T143	R:R:Y150	8.74	No	Yes	0	9	8
113	R:R:F145	R:R:I144	7.54	Yes	No	0	7	9
114	R:R:F145	R:R:H207	16.97	Yes	No	7	7	5
115	R:R:F145	R:R:L211	3.65	Yes	No	0	7	5
116	R:R:H152	R:R:R149	10.16	No	No	0	4	5
117	R:R:H151	R:R:Y150	8.71	No	Yes	0	4	8
118	R:R:M154	R:R:Y150	4.79	No	Yes	5	7	8
119	R:R:R158	R:R:T155	3.88	No	No	0	6	8
120	R:R:I166	R:R:W167	4.7	No	Yes	0	6	9
121	R:R:C173	R:R:F169	8.38	No	No	0	4	4
122	R:R:C173	R:R:F177	4.19	No	Yes	0	4	4
123	R:R:F177	R:R:V186	7.87	Yes	No	0	4	4
124	R:R:F177	R:R:L190	4.87	Yes	No	0	4	5
125	L:L:R8	R:R:I178	16.28	Yes	Yes	2	0	4
126	L:L:W9	R:R:I178	4.7	Yes	Yes	2	0	4
127	R:R:E182	R:R:S181	5.75	No	No	0	4	2
128	L:L:R8	R:R:S181	10.54	Yes	No	2	0	2
129	L:L:W9	R:R:S181	4.94	Yes	No	2	0	2
130	R:R:S183	R:R:Y185	6.36	No	No	0	4	1
131	R:R:I187	R:R:L258	5.71	No	No	0	5	4
132	R:R:I187	R:R:L262	5.71	No	No	0	5	3
133	L:L:W9	R:R:I187	5.87	Yes	No	0	0	5
134	R:R:L188	R:R:L262	4.15	No	No	8	4	3
135	R:R:F255	R:R:L190	3.65	No	No	0	5	5
136	L:L:W9	R:R:L190	6.83	Yes	No	0	0	5
137	R:R:F195	R:R:I191	3.77	No	No	0	4	4
138	R:R:I191	R:R:T259	4.56	No	No	0	4	4
139	R:R:F194	R:R:F195	7.5	Yes	No	0	7	4
140	R:R:F194	R:R:L198	3.65	Yes	No	6	7	6
141	R:R:F194	R:R:F247	5.36	Yes	Yes	6	7	8
142	R:R:F194	R:R:F255	23.58	Yes	No	0	7	5
143	R:R:F247	R:R:L198	4.87	Yes	No	6	8	6
144	R:R:L200	R:R:L204	4.15	No	Yes	0	5	7
145	R:R:L201	R:R:Y205	4.69	No	No	0	8	9
146	R:R:F247	R:R:L201	8.53	Yes	No	0	8	8
147	R:R:L244	R:R:V202	4.47	Yes	No	0	7	5
148	R:R:L243	R:R:Y205	5.86	Yes	No	0	8	9
149	R:R:F209	R:R:R213	7.48	Yes	No	0	6	5
150	R:R:F209	R:R:V240	3.93	Yes	No	0	6	8
151	R:R:H215	R:R:L211	3.86	No	No	0	7	5
152	R:R:K217	R:R:R213	3.71	No	No	0	5	5
153	R:R:R213	R:R:S233	6.59	No	No	0	5	6
154	R:R:H215	R:R:T214	5.48	No	No	0	7	5
155	R:R:H215	R:R:R218	4.51	No	No	0	7	5
156	R:R:R231	R:R:V216	3.92	No	No	0	4	6
157	R:R:A220	R:R:R231	6.91	No	No	0	4	4
158	R:R:I294	R:R:L243	4.28	Yes	Yes	1	9	8
159	R:R:L243	R:R:Y295	8.21	Yes	Yes	1	8	9
160	R:R:M290	R:R:V246	9.13	No	No	0	6	6
161	R:R:F247	R:R:W251	5.01	Yes	Yes	0	8	7
162	R:R:C250	R:R:N287	6.3	No	No	0	8	9
163	R:R:I284	R:R:W251	11.74	No	Yes	0	7	7
164	R:R:N287	R:R:W251	16.95	No	Yes	0	9	7
165	R:R:P253	R:R:Y280	6.95	No	Yes	0	9	5
166	R:R:L283	R:R:P253	4.93	No	No	0	7	9
167	R:R:F254	R:R:F255	8.57	Yes	No	0	5	5
168	R:R:F254	R:R:L258	6.09	Yes	No	0	5	4
169	R:R:F254	R:R:F277	5.36	Yes	Yes	0	5	4
170	R:R:F254	R:R:I284	6.28	Yes	No	0	5	7
171	R:R:F273	R:R:L256	3.65	No	No	0	4	4
172	R:R:H257	R:R:M261	3.94	Yes	No	0	4	4
173	R:R:H257	R:R:M274	11.82	Yes	No	0	4	1
174	R:R:F277	R:R:H257	14.71	Yes	Yes	0	4	4
175	R:R:H257	R:R:Y280	6.53	Yes	Yes	0	4	5
176	R:R:L260	R:R:S263	4.5	Yes	No	4	3	4
177	R:R:C264	R:R:L260	4.76	Yes	Yes	4	3	3
178	R:R:C270	R:R:L260	4.76	No	Yes	4	2	3
179	R:R:F273	R:R:L260	3.65	No	Yes	0	4	3
180	R:R:C264	R:R:S263	5.16	Yes	No	4	3	4
181	R:R:C264	R:R:C270	7.28	Yes	No	4	3	2
182	R:R:P265	R:R:Q266	11.05	No	No	0	2	1
183	R:R:F273	R:R:Y280	15.47	No	Yes	0	4	5
184	R:R:H276	R:R:Y280	7.62	No	Yes	0	3	5
185	R:R:F277	R:R:L281	6.09	Yes	No	0	4	3
186	L:L:G10	R:R:F277	9.03	No	Yes	0	0	4
187	L:L:H6	R:R:N278	12.75	No	No	0	0	3
188	R:R:D291	R:R:N287	10.77	Yes	No	0	9	9
189	R:R:I294	R:R:Y295	7.25	Yes	Yes	1	9	9
190	R:R:F297	R:R:F306	17.15	No	No	0	6	6
191	R:R:E301	R:R:S299	5.75	Yes	No	3	7	8
192	R:R:Q300	R:R:R303	5.84	No	No	0	5	9
193	R:R:F306	R:R:M302	7.46	No	Yes	0	6	8
194	R:R:E308	R:R:K304	4.05	No	No	0	5	5
195	L:L:E5	L:L:K11	5.4	No	No	0	0	0
196	L:L:F7	L:L:W9	7.02	No	Yes	0	0	0
197	L:L:R8	L:L:W9	14.99	Yes	Yes	2	0	0
198	L:L:K11	L:L:P12	5.02	No	No	0	0	0
199	R:R:A79	R:R:V57	3.39	No	No	0	9	9
200	R:R:A296	R:R:V57	3.39	No	No	0	8	9
201	R:R:F73	R:R:H68	3.39	No	No	0	4	8
202	R:R:F110	R:R:H113	3.39	No	No	0	3	4
203	R:R:A60	R:R:T305	3.36	No	No	0	8	7
204	R:R:L222	R:R:P223	3.28	No	No	0	3	2
205	R:R:A79	R:R:I58	3.25	No	Yes	0	9	8
206	R:R:S125	R:R:V85	3.23	No	No	0	6	8
207	R:R:S183	R:R:V186	3.23	No	No	0	4	4
208	R:R:S233	R:R:V216	3.23	No	No	0	6	6
209	R:R:T93	R:R:V40	3.17	No	No	0	6	4
210	R:R:C286	R:R:L46	3.17	No	No	0	5	6
211	L:L:P12	R:R:Q266	3.16	No	No	0	0	1
212	R:R:A137	R:R:L204	3.15	No	Yes	0	9	7
213	R:R:C264	R:R:N267	3.15	Yes	No	0	3	3
214	R:R:I58	R:R:V80	3.07	Yes	No	0	8	5
215	R:R:I61	R:R:V75	3.07	No	No	0	8	8
216	R:R:I136	R:R:V75	3.07	No	No	0	9	8
217	R:R:I153	R:R:V142	3.07	No	No	0	6	6
218	R:R:I294	R:R:V246	3.07	Yes	No	0	9	6
219	R:R:M274	R:R:S271	3.07	No	No	0	1	1
220	R:R:F209	R:R:G236	3.01	Yes	No	0	6	8
221	R:R:L204	R:R:V138	2.98	Yes	No	0	7	7
222	R:R:L244	R:R:V240	2.98	Yes	No	0	7	8
223	R:R:L188	R:R:T184	2.95	No	No	8	4	3
224	R:R:L262	R:R:T184	2.95	No	No	8	3	3
225	R:R:L243	R:R:T239	2.95	Yes	No	0	8	9
226	R:R:A109	R:R:H113	2.93	No	No	0	2	4
227	R:R:I144	R:R:M208	2.92	No	No	0	9	9
228	R:R:I294	R:R:M242	2.92	Yes	No	0	9	6
229	R:R:Q235	R:R:V238	2.87	No	No	0	8	6
230	R:R:I106	R:R:L104	2.85	No	No	0	5	5
231	R:R:I206	R:R:L210	2.85	No	No	0	4	3
232	R:R:I219	R:R:L222	2.85	No	No	0	5	3
233	R:R:L51	R:R:M83	2.83	No	No	0	6	7
234	R:R:C189	R:R:F177	2.79	No	Yes	0	4	4
235	R:R:H276	R:R:S275	2.79	No	No	0	3	2
236	R:R:A252	R:R:F194	2.77	No	Yes	0	5	7
237	R:R:L201	R:R:L244	2.77	No	Yes	0	8	7
238	L:L:H6	R:R:T93	2.74	No	No	0	0	6
239	R:R:N64	R:R:N66	2.72	No	No	0	7	6
240	R:R:H276	R:R:M279	2.63	No	No	0	3	4
241	R:R:F177	R:R:V176	2.62	Yes	No	0	4	5
242	R:R:A81	R:R:W167	2.59	No	Yes	0	8	9
243	R:R:H103	R:R:N101	2.55	No	No	0	3	4
244	R:R:F74	R:R:I162	2.51	Yes	No	0	8	6
245	R:R:F118	R:R:I114	2.51	Yes	No	0	6	4
246	R:R:F118	R:R:M121	2.49	Yes	No	0	6	5
247	R:R:F177	R:R:M193	2.49	Yes	No	0	4	4
248	R:R:M242	R:R:R298	2.48	No	No	0	6	8
249	R:R:F209	R:R:L210	2.44	Yes	No	0	6	3
250	R:R:I153	R:R:Y146	2.42	No	No	0	6	6
251	R:R:I124	R:R:W167	2.35	No	Yes	0	4	9
252	R:R:L179	R:R:Y180	2.34	No	No	0	3	3
253	R:R:M87	R:R:W91	2.33	No	No	0	5	7
254	R:R:L84	R:R:W167	2.28	No	Yes	0	6	9
255	R:R:R272	R:R:Y269	2.06	No	No	0	4	4
256	R:R:F118	R:R:W91	2	Yes	No	0	6	7
257	R:R:A164	R:R:G165	1.95	No	No	0	4	4
258	R:R:C264	R:R:P265	1.88	Yes	No	0	3	2
259	R:R:G160	R:R:S159	1.86	No	No	0	1	7
260	R:R:G172	R:R:T171	1.82	No	No	0	3	3
261	R:R:G245	R:R:T248	1.82	No	No	0	5	5
262	R:R:G59	R:R:K63	1.74	No	No	0	4	5
263	R:R:G245	R:R:L244	1.71	No	Yes	0	5	7
264	R:R:A39	R:R:V42	1.7	No	No	0	4	5
265	R:R:G236	R:R:Q235	1.64	No	No	0	8	8
266	R:R:C311	R:R:I310	1.64	No	No	0	6	5
267	R:R:A90	R:R:L44	1.58	No	No	0	6	5
268	R:R:I124	R:R:S120	1.55	No	No	0	4	5
269	R:R:I175	R:R:S120	1.55	No	No	0	3	5
270	R:R:I178	R:R:S120	1.55	Yes	No	0	4	5
271	R:R:I58	R:R:V62	1.54	Yes	No	0	8	3
272	R:R:I49	R:R:T45	1.52	No	No	0	5	3
273	R:R:M121	R:R:V117	1.52	No	No	0	5	4
274	R:R:I309	R:R:T305	1.52	No	No	0	7	7
275	R:R:M234	R:R:T232	1.51	No	No	0	5	5
276	R:R:L200	R:R:S203	1.5	No	No	0	5	4
277	R:R:L44	R:R:V40	1.49	No	No	0	5	4
278	R:R:L52	R:R:V48	1.49	No	No	0	5	5
279	L:L:S3	R:R:N100	1.49	No	No	0	0	3
280	R:R:I309	R:R:K63	1.45	No	No	0	7	5
281	R:R:I94	R:R:L98	1.43	No	No	0	5	4
282	R:R:I175	R:R:L179	1.43	No	No	0	3	3
283	R:R:Q235	R:R:T232	1.42	No	No	0	8	5
284	R:R:A156	R:R:F73	1.39	No	No	0	2	4
285	R:R:A237	R:R:F209	1.39	No	Yes	0	7	6
286	R:R:L104	R:R:L98	1.38	No	No	0	5	4
287	R:R:L104	R:R:L99	1.38	No	No	0	5	2
288	R:R:R157	R:R:T155	1.29	No	No	0	4	8
289	R:R:E301	R:R:Q300	1.27	Yes	No	0	7	5
290	L:L:S1	L:L:Y2	1.27	No	Yes	0	0	0
291	R:R:I219	R:R:R231	1.25	No	No	0	5	4
292	R:R:M154	R:R:R158	1.24	No	No	0	7	6
293	R:R:L268	R:R:R272	1.21	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N54	5.6025	4	0	9
2	R:R:I58	3.1925	4	0	8
3	R:R:L67	7.8	4	3	9
4	R:R:Y72	6.03571	7	3	8
5	R:R:F74	5.4425	4	0	8
6	R:R:L78	5.895	4	1	9
7	R:R:D82	7.25	5	1	9
8	R:R:E92	8.932	5	2	6
9	R:R:D115	8.24833	6	2	8
10	R:R:F118	6.17	5	0	6
11	R:R:D119	10.0083	6	2	4
12	R:R:R140	6.9175	4	1	9
13	R:R:F145	11.6825	4	7	7
14	R:R:Y150	6.18333	6	5	8
15	R:R:W167	4.32333	6	0	9
16	R:R:F177	4.14571	7	0	4
17	R:R:I178	6.6825	4	2	4
18	R:R:F194	7.97333	6	6	7
19	R:R:L204	4.3275	4	0	7
20	R:R:F209	3.65	5	0	6
21	R:R:L243	5.325	4	1	8
22	R:R:L244	2.9825	4	0	7
23	R:R:F247	5.9425	4	6	8
24	R:R:W251	10.57	4	0	7
25	R:R:F254	6.575	4	0	5
26	R:R:H257	9.25	4	0	4
27	R:R:L260	4.4175	4	4	3
28	R:R:C264	4.446	5	4	3
29	R:R:F277	8.7975	4	0	4
30	R:R:Y280	9.1425	4	0	5
31	R:R:D291	7.75	4	1	9
32	R:R:I294	4.38	4	1	9
33	R:R:Y295	6.678	5	1	9
34	R:R:E301	4.2025	4	3	7
35	R:R:M302	6.275	4	3	8
36	L:L:Y2	6.11	4	0	0
37	L:L:R8	12.3417	6	2	0
38	L:L:W9	7.39167	6	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F43	R:R:T93	29.1121	9.08	No	No	0	6	6
2	L:L:H6	R:R:T93	18.5169	2.74	No	No	0	0	6
3	L:L:H6	R:R:N278	15.899	12.75	No	No	0	0	3
4	R:R:I38	R:R:N278	13.3613	4.25	No	No	0	3	3
5	R:R:F43	R:R:S89	33.9281	3.96	No	No	0	6	6
6	R:R:I122	R:R:S89	36.3423	6.19	No	No	0	5	6
7	L:L:F7	R:R:I122	41.1768	20.09	No	No	0	0	5
8	L:L:F7	R:R:D119	33.6318	7.17	No	Yes	0	0	4
9	R:R:D119	R:R:I178	50.7471	4.2	Yes	Yes	2	4	4
10	R:R:I178	R:R:S120	52.5624	1.55	Yes	No	0	4	5
11	R:R:I124	R:R:S120	49.7962	1.55	No	No	0	4	5
12	R:R:I124	R:R:W167	47.8143	2.35	No	Yes	0	4	9
13	R:R:S77	R:R:W167	48.1847	4.94	No	Yes	0	9	9
14	R:R:S132	R:R:S77	29.7049	6.52	No	No	0	8	9
15	R:R:L78	R:R:S132	29.9271	4.5	Yes	No	0	9	8
16	R:R:D82	R:R:L78	25.5557	8.14	Yes	Yes	1	9	9
17	R:R:D82	R:R:N54	43.023	6.73	Yes	Yes	0	9	9
18	R:R:N54	R:R:P292	20.8385	6.52	Yes	No	0	9	9
19	R:R:E53	R:R:P292	18.2761	4.72	No	No	0	8	9
20	R:R:E53	R:R:V289	13.1143	4.28	No	No	0	8	6
21	L:L:F7	L:L:W9	57.6871	7.02	No	Yes	0	0	0
22	L:L:W9	R:R:I178	45.1531	4.7	Yes	Yes	2	0	4
23	L:L:W9	R:R:I187	34.9099	5.87	Yes	No	0	0	5
24	R:R:I187	R:R:L258	33.8232	5.71	No	No	0	5	4
25	R:R:F254	R:R:L258	34.4406	6.09	Yes	No	0	5	4
26	R:R:F254	R:R:I284	39.1887	6.28	Yes	No	0	5	7
27	R:R:I284	R:R:W251	38.2378	11.74	No	Yes	0	7	7
28	R:R:N287	R:R:W251	37.7686	16.95	No	Yes	0	9	7
29	R:R:D291	R:R:N287	33.4218	10.77	Yes	No	0	9	9
30	R:R:D291	R:R:D82	32.2302	6.65	Yes	Yes	1	9	9
31	L:L:W9	R:R:L190	96.4683	6.83	Yes	No	0	0	5
32	R:R:F255	R:R:L190	100	3.65	No	No	0	5	5
33	R:R:F254	R:R:F255	51.4078	8.57	Yes	No	0	5	5
34	R:R:F194	R:R:F255	86.6757	23.58	Yes	No	0	7	5
35	R:R:F194	R:R:F247	76.6732	5.36	Yes	Yes	6	7	8
36	R:R:F247	R:R:W251	35.1877	5.01	Yes	Yes	0	8	7
37	R:R:D82	R:R:S288	10.1939	10.31	Yes	No	1	9	9
38	R:R:D119	R:R:E92	85.731	7.8	Yes	Yes	2	4	6
39	R:R:E92	R:R:F118	74.5369	18.66	Yes	Yes	0	6	6
40	R:R:F118	R:R:W91	18.3564	2	Yes	No	0	6	7
41	R:R:M87	R:R:W91	14.7135	2.33	No	No	0	5	7
42	R:R:L51	R:R:M87	11.0521	11.31	No	No	0	6	5
43	R:R:A79	R:R:N54	18.2761	4.69	No	Yes	0	9	9
44	R:R:M71	R:R:Y72	35.9657	3.59	No	Yes	0	9	8
45	R:R:M71	R:R:R140	52.0005	6.2	No	Yes	0	9	9
46	R:R:R140	R:R:Y205	46.0361	9.26	Yes	No	0	9	9
47	R:R:L201	R:R:Y205	59.5147	4.69	No	No	0	8	9
48	R:R:F247	R:R:L201	84.8049	8.53	Yes	No	0	8	8
49	R:R:A79	R:R:I58	10.5149	3.25	No	Yes	0	9	8
50	R:R:L67	R:R:Y72	15.5532	10.55	Yes	Yes	3	9	8
51	R:R:L67	R:R:N64	14.1269	6.87	Yes	No	0	9	7
52	R:R:N64	R:R:T305	10.1507	7.31	No	No	0	7	7
53	R:R:P70	R:R:S159	12.9229	7.13	No	No	0	6	7
54	R:R:P70	R:R:Y150	14.8617	4.17	No	Yes	5	6	8
55	R:R:D139	R:R:Y150	35.4717	6.9	No	Yes	0	9	8
56	R:R:D139	R:R:F74	27.2783	7.17	No	Yes	0	9	8
57	R:R:F74	R:R:I163	27.6118	3.77	Yes	No	0	8	8
58	R:R:I163	R:R:S77	28.2539	4.64	No	No	0	8	9
59	R:R:L133	R:R:L78	15.9422	4.15	No	Yes	1	8	9
60	R:R:D291	R:R:L133	11.7375	6.79	Yes	No	1	9	8
61	R:R:E92	R:R:I96	10.6076	6.83	Yes	No	2	6	4
62	R:R:L104	R:R:L98	16.041	1.38	No	No	0	5	4
63	R:R:L104	R:R:L99	33.2366	1.38	No	No	0	5	2
64	R:R:L99	R:R:T95	40.0531	4.42	No	No	0	2	4
65	R:R:H103	R:R:L98	11.0521	3.86	No	No	0	3	4
66	R:R:F110	R:R:I106	11.0521	5.02	No	No	0	3	5
67	R:R:I106	R:R:L104	14.7135	2.85	No	No	0	5	5
68	L:L:R8	R:R:D119	24.9815	20.25	Yes	Yes	2	0	4
69	L:L:R8	L:L:W9	36.0706	14.99	Yes	Yes	2	0	0
70	R:R:F177	R:R:L190	22.4994	4.87	Yes	No	0	4	5
71	R:R:F194	R:R:M130	31.6189	4.98	Yes	No	0	7	7
72	R:R:M130	R:R:M197	29.853	4.33	No	No	0	7	7
73	R:R:R140	R:R:Y295	17.3191	7.2	Yes	Yes	1	9	9
74	R:R:L243	R:R:Y205	14.1763	5.86	Yes	No	0	8	9
75	R:R:L134	R:R:M197	28.0748	11.31	No	No	0	7	7
76	R:R:L134	R:R:L200	26.2843	6.92	No	No	0	7	5
77	R:R:F145	R:R:Y141	13.3613	18.57	Yes	No	7	7	8
78	R:R:L204	R:R:Y141	17.1462	7.03	Yes	No	0	7	8
79	R:R:L200	R:R:L204	22.6661	4.15	No	Yes	0	5	7
80	R:R:L201	R:R:L244	51.346	2.77	No	Yes	0	8	7
81	R:R:F209	R:R:V240	40.6952	3.93	Yes	No	0	6	8
82	R:R:L244	R:R:V240	42.8501	2.98	Yes	No	0	7	8
83	R:R:F209	R:R:R213	20.8323	7.48	Yes	No	0	6	5
84	R:R:R213	R:R:S233	16.2571	6.59	No	No	0	5	6
85	R:R:S233	R:R:V216	14.0652	3.23	No	No	0	6	6
86	R:R:R231	R:R:V216	11.756	3.92	No	No	0	4	6
87	R:R:F254	R:R:F277	78.0748	5.36	Yes	Yes	0	5	4
88	R:R:F277	R:R:H257	69.2517	14.71	Yes	Yes	0	4	4
89	R:R:H257	R:R:Y280	57.0758	6.53	Yes	Yes	0	4	5
90	R:R:F273	R:R:Y280	38.4416	15.47	No	Yes	0	4	5
91	R:R:F273	R:R:L260	32.1314	3.65	No	Yes	0	4	3
92	R:R:C264	R:R:L260	22.487	4.76	Yes	Yes	4	3	3
93	R:R:C264	R:R:P265	16.1398	1.88	Yes	No	0	3	2
94	R:R:P265	R:R:Q266	12.9044	11.05	No	No	0	2	1
95	R:R:F209	R:R:G236	11.6449	3.01	Yes	No	0	6	8
96	R:R:F118	R:R:T95	43.4613	5.19	Yes	No	0	6	4
97	R:R:D139	R:R:M71	35.2494	5.54	No	No	0	9	9
98	R:R:L133	R:R:Y295	26.4942	4.69	No	Yes	1	8	9
99	L:L:R8	R:R:D115	11.6449	5.96	Yes	Yes	2	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I38	R:R:N278	4.25	0	No	No	3	3	2	1
R:R:F43	R:R:S89	3.96	0	No	No	6	6	2	2
R:R:F43	R:R:T93	9.08	0	No	No	6	6	2	1
R:R:I122	R:R:S88	4.64	0	No	No	5	6	1	2
R:R:I122	R:R:S89	6.19	0	No	No	5	6	1	2
R:R:E92	R:R:I96	6.83	2	Yes	No	6	4	1	1
R:R:E92	R:R:F118	18.66	2	Yes	Yes	6	6	1	2
R:R:D119	R:R:E92	7.8	2	Yes	Yes	4	6	1	1
L:L:M4	R:R:E92	4.06	2	No	Yes	0	6	0	1
I:I:?1	R:R:E92	7.31	2	No	Yes	0	6	2	1
R:R:I96	R:R:N100	4.25	2	No	No	4	3	1	1
L:L:M4	R:R:I96	8.75	2	No	No	0	4	0	1
L:L:Y2	R:R:D108	4.6	0	Yes	No	0	2	0	1
R:R:N116	R:R:R112	4.82	2	No	No	4	3	1	1
L:L:Y2	R:R:R112	8.23	0	Yes	No	0	3	0	1
R:R:D115	R:R:N116	6.73	2	Yes	No	8	4	1	1
R:R:D115	R:R:D119	10.65	2	Yes	Yes	8	4	1	1
L:L:Y2	R:R:D115	10.34	0	Yes	Yes	0	8	0	1
L:L:M4	R:R:D115	8.32	2	No	Yes	0	8	0	1
L:L:R8	R:R:D115	5.96	2	Yes	Yes	0	8	0	1
I:I:?1	R:R:D115	7.49	2	No	Yes	0	8	2	1
L:L:R8	R:R:N116	6.03	2	Yes	No	0	4	0	1
R:R:D119	R:R:I178	4.2	2	Yes	Yes	4	4	1	1
L:L:F7	R:R:D119	7.17	0	No	Yes	0	4	0	1
L:L:R8	R:R:D119	20.25	2	Yes	Yes	0	4	0	1
I:I:?1	R:R:D119	9.98	2	No	Yes	0	4	2	1
L:L:F7	R:R:I122	20.09	0	No	No	0	5	0	1
R:R:F177	R:R:L190	4.87	0	Yes	No	4	5	2	1
L:L:R8	R:R:I178	16.28	2	Yes	Yes	0	4	0	1
L:L:W9	R:R:I178	4.7	2	Yes	Yes	0	4	0	1
R:R:E182	R:R:S181	5.75	0	No	No	4	2	2	1
L:L:R8	R:R:S181	10.54	2	Yes	No	0	2	0	1
L:L:W9	R:R:S181	4.94	2	Yes	No	0	2	0	1
R:R:I187	R:R:L258	5.71	0	No	No	5	4	1	2
R:R:I187	R:R:L262	5.71	0	No	No	5	3	1	2
L:L:W9	R:R:I187	5.87	2	Yes	No	0	5	0	1
R:R:F255	R:R:L190	3.65	0	No	No	5	5	2	1
L:L:W9	R:R:L190	6.83	2	Yes	No	0	5	0	1
R:R:F254	R:R:F255	8.57	0	Yes	No	5	5	2	2
R:R:F254	R:R:L258	6.09	0	Yes	No	5	4	2	2
R:R:F254	R:R:F277	5.36	0	Yes	Yes	5	4	2	1
R:R:F277	R:R:H257	14.71	0	Yes	Yes	4	4	1	2
R:R:P265	R:R:Q266	11.05	0	No	No	2	1	2	1
R:R:F277	R:R:L281	6.09	0	Yes	No	4	3	1	2
L:L:G10	R:R:F277	9.03	0	No	Yes	0	4	0	1
L:L:H6	R:R:N278	12.75	0	No	No	0	3	0	1
R:R:T93	R:R:V40	3.17	0	No	No	6	4	1	2
L:L:P12	R:R:Q266	3.16	0	No	No	0	1	0	1
L:L:H6	R:R:T93	2.74	0	No	No	0	6	0	1
R:R:I178	R:R:S120	1.55	2	Yes	No	4	5	1	2
L:L:S3	R:R:N100	1.49	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8INR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	265
Number of Links	293
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	53197
Length Of Smallest Path	3
Average Path Length	13.1125
Length of Longest Path	27
Minimum Path Strength	1.38
Average Path Strength	6.80396
Maximum Path Strength	17.62
Minimum Path Correlation	0.7
Average Path Correlation	0.936584
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	54.1029
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1744
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body • melanocortin receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • hormone activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide signaling pathway • circulatory system process • regulation of blood pressure • blood circulation • regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • lipid localization • endocrine process • regulation of lipid localization • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • calcium-mediated signaling • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • glucose homeostasis • carbohydrate homeostasis • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen • identical protein binding • host cell surface binding • host cell surface receptor binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • hormone binding • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • membrane fusion • fusion of virus membrane with host plasma membrane • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • vesicle-mediated transport • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P33032
Sequence	>8INR_nogp_Chain_R I A V E V F L T L G V I S L L E N I L V I G A I V K N K N L H S P M Y F F V C S L A V A D M L V S M S S A W E T I T I Y L L N N K H L V I A D A F V R H I D N V F D S M I C I S V V A S M C S L L A I A V D R Y V T I F Y A L R Y H H I M T A R R S G A I I A G I W A F C T G C G I V F I L Y S E S T Y V I L C L I S M F F A M L F L L V S L Y I H M F L L A R T H V K R I A A L P G A S R T S M Q G A V T V T M L L G V F T V C W A P F F L H L T L M L S C P Q N L Y C S R F M S H F N M Y L I L I M C N S V M D P L I Y A F R S Q E M R K T F K E I I C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8INR	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.73	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8INR (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca		2.73	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOD	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca	chim(NtGi1-Gs)/β1/γ2	2.59	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOD (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca		2.59	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	9K3H	A	Peptide	Melanocortin	MC₅	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.86	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3H (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	-	-		2.86	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8INR_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.