psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?0	L:L:?1	21.38	Yes	Yes	1	0	0
2	L:L:?0	R:R:V111	4.46	Yes	No	0	0	3
3	L:L:?0	R:R:D115	16.26	Yes	Yes	1	0	8
4	L:L:?1	L:L:D2	8.91	Yes	No	1	0	0
5	L:L:?1	R:R:T95	5.53	Yes	No	0	0	4
6	L:L:?1	R:R:I96	14.72	Yes	No	0	0	4
7	L:L:?1	R:R:D115	16.54	Yes	Yes	1	0	8
8	L:L:D2	L:L:P3	4.83	No	No	1	0	0
9	L:L:D2	L:L:K7	9.68	No	Yes	1	0	0
10	L:L:K7	L:L:P3	6.69	Yes	No	1	0	0
11	L:L:P3	R:R:I96	5.08	No	No	0	0	4
12	L:L:?4	L:L:R5	11.69	Yes	Yes	1	0	0
13	L:L:?4	L:L:W6	6.39	Yes	Yes	0	0	0
14	L:L:?4	R:R:E92	6.37	Yes	Yes	1	0	6
15	L:L:?4	R:R:D119	8.7	Yes	Yes	1	0	4
16	L:L:?4	R:R:I122	17.17	Yes	No	0	0	5
17	L:L:?4	R:R:V126	5.97	Yes	No	0	0	6
18	L:L:?4	R:R:F254	11.72	Yes	Yes	0	0	5
19	L:L:?4	R:R:L281	4.44	Yes	No	0	0	3
20	I:I:?1	L:L:?4	8.16	Yes	Yes	1	0	0
21	L:L:R5	R:R:N116	4.82	Yes	No	0	0	4
22	L:L:R5	R:R:D119	19.06	Yes	Yes	1	0	4
23	L:L:R5	R:R:I178	7.52	Yes	No	0	0	4
24	L:L:R5	R:R:S181	9.22	Yes	No	0	0	2
25	I:I:?1	L:L:R5	4.47	Yes	Yes	1	0	0
26	L:L:W6	R:R:S181	6.18	Yes	No	0	0	2
27	L:L:W6	R:R:I187	10.57	Yes	No	0	0	5
28	L:L:W6	R:R:L258	4.56	Yes	No	0	0	4
29	L:L:?8	L:L:K7	10.47	No	Yes	0	0	0
30	L:L:K7	R:R:F277	19.85	Yes	Yes	0	0	4
31	L:L:?8	R:R:H257	6.36	No	Yes	0	0	4
32	R:R:I282	R:R:V42	9.22	No	No	0	4	5
33	R:R:F43	R:R:T93	12.97	Yes	No	0	6	6
34	R:R:F43	R:R:N278	7.25	Yes	No	0	6	3
35	R:R:F43	R:R:L281	4.87	Yes	No	0	6	3
36	R:R:F43	R:R:I282	11.3	Yes	No	0	6	4
37	R:R:F43	R:R:M285	4.98	Yes	No	0	6	6
38	R:R:I49	R:R:V289	6.14	No	No	0	5	6
39	R:R:S50	R:R:S86	6.52	No	No	0	8	8
40	R:R:E53	R:R:V289	5.7	No	No	0	8	6
41	R:R:E53	R:R:P292	12.58	No	No	0	8	9
42	R:R:E53	R:R:F297	4.66	No	No	0	8	6
43	R:R:D82	R:R:N54	9.42	Yes	No	0	9	9
44	R:R:N54	R:R:P292	8.15	No	No	0	9	9
45	R:R:I55	R:R:M83	4.37	No	No	0	5	7
46	R:R:F306	R:R:L56	8.53	Yes	No	0	6	7
47	R:R:A296	R:R:V57	5.09	No	No	0	8	9
48	R:R:C76	R:R:I58	4.91	No	No	0	7	8
49	R:R:I58	R:R:V80	4.61	No	No	0	8	5
50	R:R:C76	R:R:I61	9.82	No	No	0	7	8
51	R:R:I309	R:R:K63	4.36	No	No	0	7	5
52	R:R:N64	R:R:N66	12.26	Yes	No	2	7	6
53	R:R:L67	R:R:N64	12.36	No	Yes	2	9	7
54	R:R:N64	R:R:T305	4.39	Yes	No	0	7	7
55	R:R:L67	R:R:N66	5.49	No	No	2	9	6
56	R:R:L67	R:R:Y72	11.72	No	Yes	2	9	8
57	R:R:F73	R:R:H68	10.18	No	No	0	4	8
58	R:R:P70	R:R:S69	7.13	No	No	0	6	7
59	R:R:D139	R:R:P70	4.83	Yes	No	0	9	6
60	R:R:P70	R:R:S159	7.13	No	No	0	6	7
61	R:R:D139	R:R:M71	8.32	Yes	No	0	9	9
62	R:R:M71	R:R:R140	11.17	No	Yes	0	9	9
63	R:R:S299	R:R:Y72	6.36	No	Yes	2	8	8
64	R:R:E301	R:R:Y72	11.22	No	Yes	2	7	8
65	R:R:M302	R:R:Y72	11.97	No	Yes	2	8	8
66	R:R:F73	R:R:S159	6.61	No	No	0	4	7
67	R:R:A135	R:R:F74	9.71	No	Yes	0	7	8
68	R:R:D139	R:R:F74	5.97	Yes	Yes	0	9	8
69	R:R:F74	R:R:I162	6.28	Yes	No	0	8	6
70	R:R:F74	R:R:I163	5.02	Yes	No	0	8	8
71	R:R:I136	R:R:V75	4.61	No	No	0	9	8
72	R:R:S132	R:R:S77	6.52	No	No	0	8	9
73	R:R:I163	R:R:S77	4.64	No	No	0	8	9
74	R:R:S77	R:R:W167	6.18	No	Yes	0	9	9
75	R:R:D82	R:R:L78	8.14	Yes	No	5	9	9
76	R:R:D291	R:R:L78	6.79	Yes	No	5	9	9
77	R:R:V80	R:R:W167	6.13	No	Yes	0	5	9
78	R:R:D82	R:R:S129	7.36	Yes	No	0	9	9
79	R:R:D82	R:R:S288	8.83	Yes	No	0	9	9
80	R:R:D291	R:R:D82	5.32	Yes	Yes	5	9	9
81	R:R:L84	R:R:S125	6.01	No	No	0	6	6
82	R:R:V126	R:R:V85	4.81	No	No	0	6	8
83	R:R:M121	R:R:S88	7.67	No	No	0	5	6
84	R:R:I122	R:R:S88	9.29	No	No	0	5	6
85	R:R:I122	R:R:S89	9.29	No	No	0	5	6
86	R:R:E92	R:R:F118	7	Yes	Yes	0	6	6
87	R:R:D119	R:R:E92	9.09	Yes	Yes	1	4	6
88	I:I:?1	R:R:E92	7.31	Yes	Yes	1	0	6
89	R:R:F118	R:R:T95	6.49	Yes	No	0	6	4
90	R:R:N101	R:R:Y97	6.98	No	No	0	4	4
91	R:R:L99	R:R:V111	4.47	No	No	0	2	3
92	R:R:H103	R:R:N101	11.48	No	No	0	3	4
93	R:R:F118	R:R:I114	5.02	Yes	No	0	6	4
94	R:R:D115	R:R:D119	11.98	Yes	Yes	1	8	4
95	I:I:?1	R:R:D115	7.49	Yes	Yes	1	0	8
96	I:I:?1	R:R:D119	7.49	Yes	Yes	1	0	4
97	R:R:I175	R:R:S120	6.19	No	No	0	3	5
98	R:R:C123	R:R:F177	5.59	No	Yes	0	5	4
99	R:R:I124	R:R:T171	6.08	No	No	0	4	3
100	R:R:G174	R:R:I124	5.29	No	No	0	6	4
101	R:R:A128	R:R:W167	7.78	No	Yes	0	7	9
102	R:R:M130	R:R:M197	5.78	No	No	0	7	7
103	R:R:M130	R:R:W251	9.31	No	Yes	0	7	7
104	R:R:C131	R:R:I166	6.55	No	No	0	5	6
105	R:R:D291	R:R:L133	8.14	Yes	No	0	9	8
106	R:R:L133	R:R:Y295	9.38	No	Yes	0	8	9
107	R:R:L134	R:R:M197	7.07	No	No	0	7	7
108	R:R:L134	R:R:L200	6.92	No	No	0	7	5
109	R:R:I136	R:R:Y295	7.25	No	Yes	0	9	9
110	R:R:D139	R:R:Y150	6.9	Yes	Yes	0	9	8
111	R:R:R140	R:R:Y205	6.17	Yes	Yes	4	9	9
112	R:R:R140	R:R:Y295	5.14	Yes	Yes	4	9	9
113	R:R:F145	R:R:Y141	21.66	Yes	No	3	7	8
114	R:R:L204	R:R:Y141	7.03	No	No	3	7	8
115	R:R:H207	R:R:Y141	7.62	No	No	3	5	8
116	R:R:T143	R:R:Y150	9.99	No	Yes	0	9	8
117	R:R:F145	R:R:H207	15.84	Yes	No	3	7	5
118	R:R:H152	R:R:R149	10.16	No	No	0	4	5
119	R:R:H151	R:R:Y150	5.44	No	Yes	0	4	8
120	R:R:M154	R:R:Y150	4.79	No	Yes	0	7	8
121	R:R:M154	R:R:R158	6.2	No	No	0	7	6
122	R:R:C173	R:R:F169	6.98	No	No	0	4	4
123	R:R:F177	R:R:V186	6.55	Yes	No	0	4	4
124	R:R:E182	R:R:S181	7.19	No	No	0	4	2
125	R:R:S183	R:R:Y185	5.09	No	No	0	4	1
126	R:R:T184	R:R:Y185	4.99	No	No	0	3	1
127	R:R:I187	R:R:L262	8.56	No	No	0	5	3
128	R:R:F195	R:R:I191	6.28	No	No	0	4	4
129	R:R:I191	R:R:L258	5.71	No	No	0	4	4
130	R:R:I191	R:R:T259	4.56	No	No	0	4	4
131	R:R:F194	R:R:F195	6.43	Yes	No	0	7	4
132	R:R:F194	R:R:L198	6.09	Yes	No	0	7	6
133	R:R:F194	R:R:W251	8.02	Yes	Yes	6	7	7
134	R:R:F194	R:R:F255	18.22	Yes	No	6	7	5
135	R:R:F247	R:R:L198	7.31	No	No	0	8	6
136	R:R:L200	R:R:L204	6.92	No	No	3	5	7
137	R:R:L201	R:R:Y205	4.69	No	Yes	0	8	9
138	R:R:F247	R:R:L201	6.09	No	No	0	8	8
139	R:R:L244	R:R:V202	8.94	No	No	0	7	5
140	R:R:L243	R:R:Y205	5.86	No	Yes	4	8	9
141	R:R:Y205	R:R:Y295	4.96	Yes	Yes	4	9	9
142	R:R:F209	R:R:R213	5.34	Yes	No	0	6	5
143	R:R:L211	R:R:T214	4.42	No	No	0	5	5
144	R:R:R213	R:R:S233	9.22	No	No	0	5	6
145	R:R:H215	R:R:R218	6.77	No	No	0	7	5
146	R:R:I294	R:R:M242	8.75	No	No	0	9	6
147	R:R:M242	R:R:R298	4.96	No	No	0	6	8
148	R:R:L243	R:R:Y295	4.69	No	Yes	4	8	9
149	R:R:M290	R:R:V246	4.56	No	No	0	6	6
150	R:R:I294	R:R:V246	6.14	No	No	0	9	6
151	R:R:F247	R:R:W251	14.03	No	Yes	0	8	7
152	R:R:C250	R:R:N287	7.87	No	No	0	8	9
153	R:R:F255	R:R:W251	6.01	No	Yes	6	5	7
154	R:R:I284	R:R:W251	5.87	No	Yes	0	7	7
155	R:R:N287	R:R:W251	14.69	No	Yes	0	9	7
156	R:R:P253	R:R:Y280	5.56	No	Yes	0	9	5
157	R:R:L283	R:R:P253	4.93	No	No	0	7	9
158	R:R:F254	R:R:L258	9.74	Yes	No	0	5	4
159	R:R:F254	R:R:F277	6.43	Yes	Yes	0	5	4
160	R:R:F254	R:R:I284	6.28	Yes	No	0	5	7
161	R:R:H257	R:R:M274	7.88	Yes	No	0	4	1
162	R:R:F277	R:R:H257	9.05	Yes	Yes	0	4	4
163	R:R:H257	R:R:Y280	4.36	Yes	Yes	0	4	5
164	R:R:L260	R:R:S263	4.5	Yes	No	0	3	4
165	R:R:C264	R:R:L260	4.76	No	Yes	8	3	3
166	R:R:C270	R:R:L260	4.76	No	Yes	8	2	3
167	R:R:F273	R:R:L260	6.09	No	Yes	0	4	3
168	R:R:C264	R:R:C270	7.28	No	No	8	3	2
169	R:R:P265	R:R:Q266	9.47	No	No	0	2	1
170	R:R:N267	R:R:Y269	4.65	No	No	0	3	4
171	R:R:C270	R:R:N267	6.3	No	No	0	2	3
172	R:R:L268	R:R:R272	6.07	No	No	0	4	4
173	R:R:R272	R:R:Y269	5.14	No	No	0	4	4
174	R:R:F273	R:R:Y280	16.5	No	Yes	0	4	5
175	R:R:H276	R:R:Y280	4.36	No	Yes	0	3	5
176	R:R:F277	R:R:L281	14.61	Yes	No	0	4	3
177	R:R:M279	R:R:Y280	4.79	No	Yes	0	4	5
178	R:R:D291	R:R:N287	13.46	Yes	No	0	9	9
179	R:R:F297	R:R:L293	6.09	No	No	0	6	6
180	R:R:I294	R:R:Y295	6.04	No	Yes	0	9	9
181	R:R:F297	R:R:F306	7.5	No	Yes	0	6	6
182	R:R:E301	R:R:S299	11.5	No	No	2	7	8
183	R:R:M302	R:R:S299	4.6	No	No	2	8	8
184	R:R:F306	R:R:M302	4.98	Yes	No	0	6	8
185	R:R:E308	R:R:K304	5.4	No	No	0	5	5
186	R:R:G37	R:R:Y97	4.35	No	No	0	4	4
187	R:R:M83	R:R:M87	4.33	No	No	0	7	5
188	R:R:I106	R:R:L99	4.28	No	No	0	5	2
189	R:R:L51	R:R:M87	4.24	No	No	0	6	5
190	R:R:C173	R:R:F177	4.19	No	Yes	0	4	4
191	R:R:A60	R:R:F306	4.16	No	Yes	0	8	6
192	R:R:F118	R:R:W91	4.01	Yes	No	0	6	7
193	R:R:A137	R:R:Y205	4	No	Yes	0	9	9
194	R:R:F209	R:R:V240	3.93	Yes	No	0	6	8
195	R:R:C123	R:R:G174	3.92	No	No	0	5	6
196	R:R:V142	R:R:Y146	3.79	No	No	0	6	6
197	R:R:F110	R:R:I106	3.77	No	No	0	3	5
198	R:R:F145	R:R:I144	3.77	Yes	No	0	7	9
199	R:R:F177	R:R:M193	3.73	Yes	No	0	4	4
200	R:R:G47	R:R:S50	3.71	No	No	0	6	8
201	R:R:G37	R:R:V40	3.68	No	No	0	4	4
202	R:R:F145	R:R:L211	3.65	Yes	No	0	7	5
203	R:R:F177	R:R:L190	3.65	Yes	No	0	4	5
204	R:R:C131	R:R:C170	3.64	No	No	0	5	7
205	R:R:G245	R:R:T248	3.64	No	No	0	5	5
206	R:R:I153	R:R:Y146	3.63	No	No	0	6	6
207	R:R:A128	R:R:C170	3.61	No	No	0	7	7
208	R:R:P292	R:R:V57	3.53	No	No	0	9	9
209	L:L:W6	R:R:M261	3.49	Yes	No	0	0	4
210	L:L:W6	R:R:L190	3.42	Yes	No	0	0	5
211	R:R:C170	R:R:V127	3.42	No	No	0	7	6
212	R:R:A79	R:R:V57	3.39	No	No	0	9	9
213	R:R:L222	R:R:P223	3.28	No	No	0	3	2
214	R:R:S288	R:R:S86	3.26	No	No	0	9	8
215	R:R:S125	R:R:V85	3.23	No	No	0	6	8
216	R:R:R157	R:R:R158	3.2	No	No	7	4	6
217	R:R:C286	R:R:L46	3.17	No	No	0	5	6
218	R:R:I178	R:R:S120	3.1	No	No	0	4	5
219	R:R:M274	R:R:S271	3.07	No	No	0	1	1
220	R:R:F209	R:R:G236	3.01	Yes	No	0	6	8
221	R:R:K63	R:R:T305	3	No	No	0	5	7
222	R:R:L51	R:R:V48	2.98	No	No	0	6	5
223	R:R:L244	R:R:V240	2.98	No	No	0	7	8
224	R:R:L262	R:R:T184	2.95	No	No	0	3	3
225	R:R:Q235	R:R:V238	2.87	No	No	0	8	6
226	R:R:E41	R:R:V40	2.85	No	No	0	4	4
227	R:R:I94	R:R:L44	2.85	No	No	0	5	5
228	R:R:I282	R:R:L46	2.85	No	No	0	4	6
229	R:R:I94	R:R:L98	2.85	No	No	0	5	4
230	R:R:I175	R:R:L179	2.85	No	No	0	3	3
231	R:R:I206	R:R:L210	2.85	No	No	0	4	3
232	R:R:Q235	R:R:T239	2.83	No	No	0	8	9
233	R:R:M83	R:R:N54	2.8	No	No	0	7	9
234	R:R:K102	R:R:N101	2.8	No	No	0	2	4
235	R:R:C189	R:R:F177	2.79	No	Yes	0	4	4
236	R:R:A156	R:R:F73	2.77	No	No	0	2	4
237	R:R:L104	R:R:L99	2.77	No	No	0	5	2
238	R:R:A109	R:R:R112	2.77	No	No	0	2	3
239	R:R:L201	R:R:L244	2.77	No	No	0	8	7
240	R:R:A237	R:R:F209	2.77	No	Yes	0	7	6
241	R:R:E308	R:R:K63	2.7	No	No	0	5	5
242	R:R:R213	R:R:V216	2.62	No	No	0	5	6
243	R:R:A81	R:R:W167	2.59	No	Yes	0	8	9
244	R:R:H103	R:R:L98	2.57	No	No	0	3	4
245	R:R:V142	R:R:Y150	2.52	No	Yes	0	6	8
246	R:R:M208	R:R:R140	2.48	No	Yes	0	9	9
247	R:R:F209	R:R:L210	2.44	Yes	No	0	6	3
248	R:R:F273	R:R:L256	2.44	No	No	0	4	4
249	R:R:I94	R:R:W91	2.35	No	No	0	5	7
250	R:R:A164	R:R:G165	1.95	No	No	0	4	4
251	R:R:A168	R:R:G165	1.95	No	No	0	3	4
252	R:R:C264	R:R:P265	1.88	No	No	0	3	2
253	R:R:A252	R:R:P253	1.87	No	No	0	5	9
254	R:R:G160	R:R:S159	1.86	No	No	0	1	7
255	R:R:G59	R:R:V62	1.84	No	No	0	4	3
256	L:L:?0	R:R:R112	1.82	Yes	No	0	0	3
257	R:R:G172	R:R:T171	1.82	No	No	0	3	3
258	R:R:G236	R:R:T239	1.82	No	No	0	8	9
259	R:R:G59	R:R:I58	1.76	No	No	0	4	8
260	R:R:C250	R:R:V249	1.71	No	No	0	8	5
261	R:R:A252	R:R:T248	1.68	No	No	0	5	5
262	R:R:V138	R:R:V142	1.6	No	No	0	7	6
263	R:R:A225	R:R:L222	1.58	No	No	0	4	3
264	R:R:M121	R:R:V117	1.52	No	No	0	5	4
265	R:R:M234	R:R:T232	1.51	No	No	0	5	5
266	R:R:L200	R:R:S203	1.5	No	No	3	5	4
267	R:R:L204	R:R:S203	1.5	No	No	3	7	4
268	R:R:K217	R:R:T214	1.5	No	No	0	5	5
269	R:R:L46	R:R:T45	1.47	No	No	0	6	3
270	R:R:I310	R:R:K307	1.45	No	No	0	5	5
271	R:R:K304	R:R:K307	1.44	No	No	0	5	5
272	R:R:I219	R:R:L222	1.43	No	No	0	5	3
273	R:R:I96	R:R:N100	1.42	No	No	0	4	3
274	R:R:K65	R:R:N64	1.4	No	Yes	0	6	7
275	R:R:H276	R:R:S275	1.39	No	No	0	3	2
276	R:R:L51	R:R:L52	1.38	No	No	0	6	5
277	R:R:H215	R:R:T214	1.37	No	No	0	7	5
278	R:R:K304	R:R:Q300	1.36	No	No	0	5	5
279	R:R:R157	R:R:T155	1.29	No	No	7	4	8
280	R:R:R158	R:R:T155	1.29	No	No	7	6	8
281	R:R:V186	R:R:Y180	1.26	No	No	0	4	3
282	R:R:K307	R:R:R303	1.24	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?0	10.98	4	1	0
2	L:L:?1	13.416	5	1	0
3	L:L:?4	8.95667	9	1	0
4	L:L:R5	9.46333	6	1	0
5	L:L:W6	5.76833	6	0	0
6	L:L:K7	11.6725	4	1	0
7	R:R:F43	8.274	5	0	6
8	R:R:N64	7.6025	4	2	7
9	R:R:Y72	10.3175	4	2	8
10	R:R:F74	6.745	4	0	8
11	R:R:D82	7.814	5	5	9
12	R:R:E92	7.4425	4	1	6
13	R:R:D115	13.0675	4	1	8
14	R:R:F118	5.63	4	0	6
15	R:R:D119	11.264	5	1	4
16	R:R:D139	6.505	4	0	9
17	R:R:R140	6.24	4	4	9
18	R:R:F145	11.23	4	3	7
19	R:R:Y150	5.928	5	0	8
20	R:R:W167	5.67	4	0	9
21	R:R:F177	4.41667	6	0	4
22	R:R:F194	9.69	4	6	7
23	R:R:Y205	5.136	5	4	9
24	R:R:F209	3.498	5	0	6
25	R:R:W251	9.655	6	6	7
26	R:R:F254	8.5425	4	0	5
27	R:R:H257	6.9125	4	0	4
28	R:R:L260	5.0275	4	8	3
29	R:R:F277	12.485	4	0	4
30	R:R:Y280	7.114	5	0	5
31	R:R:D291	8.4275	4	5	9
32	R:R:Y295	6.24333	6	4	9
33	R:R:F306	6.2925	4	0	6
34	I:I:?1	6.984	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?0	R:R:D115	14.6229	16.26	Yes	Yes	1	0	8
2	R:R:D115	R:R:D119	10.0776	11.98	Yes	Yes	1	8	4
3	L:L:?4	R:R:D119	10.3962	8.7	Yes	Yes	1	0	4
4	I:I:?1	R:R:D115	10.0821	7.49	Yes	Yes	1	0	8
5	I:I:?1	L:L:?4	10.45	8.16	Yes	Yes	1	0	0
6	L:L:?4	L:L:W6	27.5452	6.39	Yes	Yes	0	0	0
7	L:L:?4	R:R:F254	65.2847	11.72	Yes	Yes	0	0	5
8	L:L:?4	R:R:L281	17.6426	4.44	Yes	No	0	0	3
9	L:L:W6	R:R:I187	10.6968	10.57	Yes	No	0	0	5
10	L:L:W6	R:R:L258	19.0649	4.56	Yes	No	0	0	4
11	R:R:F254	R:R:L258	19.7066	9.74	Yes	No	0	5	4
12	R:R:F277	R:R:H257	35.2358	9.05	Yes	Yes	0	4	4
13	R:R:F43	R:R:L281	16.7272	4.87	Yes	No	0	6	3
14	R:R:F254	R:R:I284	100	6.28	Yes	No	0	5	7
15	R:R:I284	R:R:W251	99.9551	5.87	No	Yes	0	7	7
16	R:R:N287	R:R:W251	48.9254	14.69	No	Yes	0	9	7
17	R:R:D291	R:R:N287	47.6062	13.46	Yes	No	0	9	9
18	R:R:D291	R:R:D82	51.3169	5.32	Yes	Yes	5	9	9
19	R:R:D82	R:R:N54	45.3179	9.42	Yes	No	0	9	9
20	R:R:N54	R:R:P292	37.6856	8.15	No	No	0	9	9
21	R:R:E53	R:R:P292	33.1269	12.58	No	No	0	8	9
22	R:R:E53	R:R:F297	29.6137	4.66	No	No	0	8	6
23	R:R:F297	R:R:F306	27.2266	7.5	No	Yes	0	6	6
24	R:R:F247	R:R:W251	57.7781	14.03	No	Yes	0	8	7
25	R:R:F247	R:R:L201	57.805	6.09	No	No	0	8	8
26	R:R:L201	R:R:Y205	49.0017	4.69	No	Yes	0	8	9
27	R:R:R140	R:R:Y205	36.694	6.17	Yes	Yes	4	9	9
28	R:R:M71	R:R:R140	45.4929	11.17	No	Yes	0	9	9
29	R:R:D139	R:R:M71	44.4968	8.32	Yes	No	0	9	9
30	R:R:D139	R:R:F74	23.8659	5.97	Yes	Yes	0	9	8
31	R:R:F74	R:R:I163	20.3123	5.02	Yes	No	0	8	8
32	R:R:I163	R:R:S77	19.1098	4.64	No	No	0	8	9
33	R:R:S77	R:R:W167	16.6779	6.18	No	Yes	0	9	9
34	R:R:F306	R:R:M302	23.5788	4.98	Yes	No	0	6	8
35	R:R:M302	R:R:Y72	19.7155	11.97	No	Yes	2	8	8
36	R:R:L67	R:R:Y72	17.2612	11.72	No	Yes	2	9	8
37	R:R:L67	R:R:N64	14.6543	12.36	No	Yes	2	9	7
38	R:R:N64	R:R:T305	12.1102	4.39	Yes	No	0	7	7
39	R:R:K63	R:R:T305	10.8	3	No	No	0	5	7
40	R:R:Y205	R:R:Y295	10.6834	4.96	Yes	Yes	4	9	9
41	R:R:D291	R:R:L133	21.5597	8.14	Yes	No	0	9	8
42	R:R:L133	R:R:Y295	20.8507	9.38	No	Yes	0	8	9
43	R:R:F118	R:R:W91	14.4928	4.01	Yes	No	0	6	7
44	R:R:I94	R:R:W91	13.214	2.35	No	No	0	5	7
45	R:R:I94	R:R:L98	10.7282	2.85	No	No	0	5	4
46	L:L:?0	R:R:V111	10.7372	4.46	Yes	No	0	0	3
47	L:L:W6	R:R:L190	27.1728	3.42	Yes	No	0	0	5
48	R:R:F177	R:R:L190	25.1851	3.65	Yes	No	0	4	5
49	R:R:C123	R:R:F177	10.6968	5.59	No	Yes	0	5	4
50	R:R:M130	R:R:W251	19.2938	9.31	No	Yes	0	7	7
51	R:R:M130	R:R:M197	18.0643	5.78	No	No	0	7	7
52	R:R:L134	R:R:M197	16.826	7.07	No	No	0	7	7
53	R:R:L134	R:R:L200	15.5786	6.92	No	No	0	7	5
54	R:R:D139	R:R:Y150	14.2101	6.9	Yes	Yes	0	9	8
55	R:R:L200	R:R:L204	13.0121	6.92	No	No	3	5	7
56	R:R:L204	R:R:Y141	11.7827	7.03	No	No	3	7	8
57	R:R:L201	R:R:L244	20.5725	2.77	No	No	0	8	7
58	R:R:L244	R:R:V240	17.7278	2.98	No	No	0	7	8
59	R:R:F209	R:R:V240	16.292	3.93	Yes	No	0	6	8
60	R:R:I294	R:R:Y295	10.5173	6.04	No	Yes	0	9	9
61	R:R:H257	R:R:Y280	31.6552	4.36	Yes	Yes	0	4	5
62	R:R:F273	R:R:Y280	18.5714	16.5	No	Yes	0	4	5
63	R:R:F273	R:R:L260	15.5651	6.09	No	Yes	0	4	3
64	R:R:E92	R:R:F118	17.0368	7	Yes	Yes	0	6	6
65	R:R:F254	R:R:F277	39.3189	6.43	Yes	Yes	0	5	4
66	R:R:F277	R:R:L281	15.601	14.61	Yes	No	0	4	3
67	L:L:?4	R:R:E92	16.8349	6.37	Yes	Yes	1	0	6
68	R:R:R140	R:R:Y295	10.6609	5.14	Yes	Yes	4	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?0	R:R:V111	4.46	1	Yes	No	0	3	0	1
L:L:?0	R:R:D115	16.26	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T95	5.53	1	Yes	No	0	4	0	1
L:L:?1	R:R:I96	14.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:D115	16.54	1	Yes	Yes	0	8	0	1
L:L:P3	R:R:I96	5.08	1	No	No	0	4	0	1
L:L:?4	R:R:E92	6.37	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:D119	8.7	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:I122	17.17	1	Yes	No	0	5	0	1
L:L:?4	R:R:V126	5.97	1	Yes	No	0	6	0	1
L:L:?4	R:R:F254	11.72	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:L281	4.44	1	Yes	No	0	3	0	1
I:I:?1	L:L:?4	8.16	1	Yes	Yes	0	0	1	0
L:L:R5	R:R:N116	4.82	1	Yes	No	0	4	0	1
L:L:R5	R:R:D119	19.06	1	Yes	Yes	0	4	0	1
L:L:R5	R:R:I178	7.52	1	Yes	No	0	4	0	1
L:L:R5	R:R:S181	9.22	1	Yes	No	0	2	0	1
I:I:?1	L:L:R5	4.47	1	Yes	Yes	0	0	1	0
L:L:W6	R:R:S181	6.18	0	Yes	No	0	2	0	1
L:L:W6	R:R:I187	10.57	0	Yes	No	0	5	0	1
L:L:W6	R:R:L258	4.56	0	Yes	No	0	4	0	1
L:L:K7	R:R:F277	19.85	1	Yes	Yes	0	4	0	1
L:L:?8	R:R:H257	6.36	0	No	Yes	0	4	0	1
R:R:F43	R:R:L281	4.87	0	Yes	No	6	3	2	1
R:R:V126	R:R:V85	4.81	0	No	No	6	8	1	2
R:R:I122	R:R:S88	9.29	0	No	No	5	6	1	2
R:R:I122	R:R:S89	9.29	0	No	No	5	6	1	2
R:R:E92	R:R:F118	7	1	Yes	Yes	6	6	1	2
R:R:D119	R:R:E92	9.09	1	Yes	Yes	4	6	1	1
I:I:?1	R:R:E92	7.31	1	Yes	Yes	0	6	1	1
R:R:F118	R:R:T95	6.49	0	Yes	No	6	4	2	1
R:R:L99	R:R:V111	4.47	0	No	No	2	3	2	1
R:R:D115	R:R:D119	11.98	1	Yes	Yes	8	4	1	1
I:I:?1	R:R:D115	7.49	1	Yes	Yes	0	8	1	1
I:I:?1	R:R:D119	7.49	1	Yes	Yes	0	4	1	1
R:R:E182	R:R:S181	7.19	0	No	No	4	2	2	1
R:R:I187	R:R:L262	8.56	0	No	No	5	3	1	2
R:R:I191	R:R:L258	5.71	0	No	No	4	4	2	1
R:R:F254	R:R:L258	9.74	0	Yes	No	5	4	1	1
R:R:F254	R:R:F277	6.43	0	Yes	Yes	5	4	1	1
R:R:F254	R:R:I284	6.28	0	Yes	No	5	7	1	2
R:R:H257	R:R:M274	7.88	0	Yes	No	4	1	1	2
R:R:F277	R:R:H257	9.05	0	Yes	Yes	4	4	1	1
R:R:H257	R:R:Y280	4.36	0	Yes	Yes	4	5	1	2
R:R:F277	R:R:L281	14.61	0	Yes	No	4	3	1	1
R:R:F177	R:R:L190	3.65	0	Yes	No	4	5	2	1
L:L:W6	R:R:M261	3.49	0	Yes	No	0	4	0	1
L:L:W6	R:R:L190	3.42	0	Yes	No	0	5	0	1
R:R:I178	R:R:S120	3.1	0	No	No	4	5	1	2
R:R:A109	R:R:R112	2.77	0	No	No	2	3	2	1
L:L:?0	R:R:R112	1.82	1	Yes	No	0	3	0	1
R:R:I96	R:R:N100	1.42	0	No	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IOD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.35
Number of Linked Nodes	258
Number of Links	282
Number of Hubs	34
Number of Links mediated by Hubs	132
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	43423
Length Of Smallest Path	3
Average Path Length	13.2116
Length of Longest Path	33
Minimum Path Strength	1.34
Average Path Strength	7.32878
Maximum Path Strength	18.05
Minimum Path Correlation	0.7
Average Path Correlation	0.935751
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	55.0046
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7134
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • identical protein binding • host cell surface binding • host cell surface receptor binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • hormone binding • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • cellular component organization • membrane fusion • fusion of virus membrane with host plasma membrane • cellular component organization or biogenesis • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • localization • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • metabolic process • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACE
PDB Residues	L:L:?0
Environment Details	Open EMBL-EBI Page
Code	ACE
Name	ACETYL GROUP
Synonyms
Identifier
Formula	C2 H4 O
Molecular Weight	44.053
SMILES
PubChem	177
Formal Charge	0
Total Atoms	7
Total Chiral Atoms	0
Total Bonds	6
Total Aromatic Bonds	0


Code	NLE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	4J2
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	4J2
Name	(2R)-2-amino-3-(naphthalen-2-yl)propanoic acid
Synonyms
Identifier
Formula	C13 H13 N O2
Molecular Weight	215.248
SMILES
PubChem	2733661
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	30
Total Aromatic Bonds	11


Code	NH2
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P33032
Sequence	>8IOD_nogp_Chain_R G I A V E V F L T L G V I S L L E N I L V I G A I V K N K N L H S P M Y F F V C S L A V A D M L V S M S S A W E T I T I Y L L N N K H L V I A D A F V R H I D N V F D S M I C I S V V A S M C S L L A I A V D R Y V T I F Y A L R Y H H I M T A R R S G A I I A G I W A F C T G C G I V F I L Y S E S T Y V I L C L I S M F F A M L F L L V S L Y I H M F L L A R T H V K R I A A L P G A T S M Q G A V T V T M L L G V F T V C W A P F F L H L T L M L S C P Q N L Y C S R F M S H F N M Y L I L I M C N S V M D P L I Y A F R S Q E M R K T F K E I I C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8INR	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.73	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8INR (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca		2.73	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOD	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca	chim(NtGi1-Gs)/β1/γ2	2.59	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOD (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca		2.59	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	9K3H	A	Peptide	Melanocortin	MC₅	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.86	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3H (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	-	-		2.86	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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