psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I38	R:R:N278	5.66	No	No	0	3	3
2	R:R:A39	R:R:E41	4.53	No	No	0	4	4
3	R:R:F43	R:R:V40	3.93	Yes	No	0	6	4
4	R:R:F43	R:R:T93	5.19	Yes	No	0	6	6
5	R:R:F43	R:R:L281	3.65	Yes	No	0	6	3
6	R:R:F43	R:R:I282	3.77	Yes	No	0	6	4
7	R:R:N54	R:R:S50	4.47	Yes	Yes	1	9	8
8	R:R:D82	R:R:S50	5.89	Yes	Yes	1	9	8
9	R:R:S50	R:R:S86	4.89	Yes	Yes	1	8	8
10	R:R:M285	R:R:S50	3.07	Yes	Yes	1	6	8
11	R:R:S288	R:R:S50	3.26	Yes	Yes	1	9	8
12	R:R:S50	R:R:V289	3.23	Yes	No	0	8	6
13	R:R:L51	R:R:M83	4.24	No	No	0	6	7
14	R:R:L51	R:R:M87	4.24	No	No	0	6	5
15	R:R:A79	R:R:N54	3.13	No	Yes	0	9	9
16	R:R:D82	R:R:N54	14.81	Yes	Yes	1	9	9
17	R:R:M83	R:R:N54	7.01	No	Yes	0	7	9
18	R:R:N54	R:R:P292	6.52	Yes	No	0	9	9
19	R:R:F306	R:R:L56	7.31	No	No	0	6	7
20	R:R:A296	R:R:V57	3.39	No	No	0	8	9
21	R:R:M302	R:R:V57	3.04	No	No	0	8	9
22	R:R:C76	R:R:I58	3.27	No	No	0	7	8
23	R:R:A79	R:R:I58	3.25	No	No	0	9	8
24	R:R:A60	R:R:T305	3.36	No	No	0	8	7
25	R:R:I61	R:R:L67	4.28	Yes	Yes	4	8	9
26	R:R:I61	R:R:Y72	4.84	Yes	Yes	4	8	8
27	R:R:C76	R:R:I61	3.27	No	Yes	0	7	8
28	R:R:I309	R:R:K63	7.27	No	No	0	7	5
29	R:R:N64	R:R:N66	8.17	No	No	0	7	6
30	R:R:L67	R:R:N64	12.36	Yes	No	0	9	7
31	R:R:N64	R:R:T305	8.77	No	No	0	7	7
32	R:R:H68	R:R:K65	20.96	No	No	0	8	6
33	R:R:L67	R:R:Y72	9.38	Yes	Yes	4	9	8
34	R:R:E301	R:R:L67	5.3	No	Yes	4	7	9
35	R:R:F73	R:R:H68	6.79	No	No	0	4	8
36	R:R:P70	R:R:S69	3.56	Yes	No	0	6	7
37	R:R:S69	R:R:Y72	6.36	No	Yes	0	7	8
38	R:R:P70	R:R:Y150	4.17	Yes	Yes	5	6	8
39	R:R:M154	R:R:P70	3.35	No	Yes	5	7	6
40	R:R:P70	R:R:S159	5.34	Yes	Yes	0	6	7
41	R:R:D139	R:R:M71	4.16	No	No	0	9	9
42	R:R:M71	R:R:R140	4.96	No	Yes	0	9	9
43	R:R:S299	R:R:Y72	5.09	No	Yes	0	8	8
44	R:R:E301	R:R:Y72	4.49	No	Yes	4	7	8
45	R:R:F73	R:R:S159	6.61	No	Yes	0	4	7
46	R:R:A135	R:R:F74	8.32	No	Yes	0	7	8
47	R:R:D139	R:R:F74	4.78	No	Yes	0	9	8
48	R:R:F74	R:R:I162	5.02	Yes	No	0	8	6
49	R:R:F74	R:R:I163	3.77	Yes	No	0	8	8
50	R:R:S132	R:R:S77	3.26	No	Yes	6	8	9
51	R:R:I163	R:R:S77	9.29	No	Yes	0	8	9
52	R:R:S77	R:R:W167	6.18	Yes	Yes	0	9	9
53	R:R:L78	R:R:S132	6.01	No	No	0	9	8
54	R:R:L133	R:R:L78	4.15	No	No	0	8	9
55	R:R:V80	R:R:W167	3.68	No	Yes	0	5	9
56	R:R:D82	R:R:S86	4.42	Yes	Yes	1	9	8
57	R:R:D82	R:R:S288	8.83	Yes	Yes	1	9	9
58	R:R:L84	R:R:S125	4.5	No	No	0	6	6
59	R:R:S125	R:R:V85	6.46	No	No	0	6	8
60	R:R:M285	R:R:S86	6.13	Yes	Yes	1	6	8
61	R:R:S288	R:R:S86	4.89	Yes	Yes	1	9	8
62	R:R:M87	R:R:W91	4.65	No	Yes	0	5	7
63	R:R:M121	R:R:S88	6.13	No	No	0	5	6
64	R:R:I122	R:R:S88	9.29	No	No	0	5	6
65	R:R:L281	R:R:S89	3	No	No	0	3	6
66	R:R:M285	R:R:S89	6.13	Yes	No	0	6	6
67	R:R:A90	R:R:W91	3.89	No	Yes	0	6	7
68	R:R:I94	R:R:W91	14.09	No	Yes	0	5	7
69	R:R:F118	R:R:W91	10.02	Yes	Yes	0	6	7
70	R:R:E92	R:R:I96	5.47	No	No	0	6	4
71	R:R:N101	R:R:Y97	20.93	No	No	0	4	4
72	R:R:L98	R:R:N101	4.12	No	No	7	4	4
73	R:R:H103	R:R:L98	3.86	No	No	7	3	4
74	R:R:L99	R:R:N100	8.24	No	No	0	2	3
75	R:R:H103	R:R:N101	7.65	No	No	7	3	4
76	R:R:H103	R:R:K102	7.86	No	No	0	3	2
77	R:R:F110	R:R:I106	13.82	Yes	No	0	3	5
78	R:R:F110	R:R:I114	3.77	Yes	No	0	3	4
79	R:R:H113	R:R:R112	20.31	No	No	0	4	3
80	R:R:D115	R:R:D119	5.32	No	No	0	8	4
81	R:R:I178	R:R:N116	9.91	No	No	0	4	4
82	R:R:F118	R:R:V117	3.93	Yes	No	0	6	4
83	R:R:F118	R:R:M121	4.98	Yes	No	0	6	5
84	R:R:I178	R:R:S120	6.19	No	No	0	4	5
85	R:R:C123	R:R:F177	13.97	No	No	0	5	4
86	R:R:G174	R:R:I124	3.53	No	No	0	6	4
87	R:R:V126	R:R:W251	7.36	No	Yes	0	6	7
88	R:R:C170	R:R:V127	5.12	No	No	0	7	6
89	R:R:M193	R:R:V127	3.04	No	No	0	4	6
90	R:R:A128	R:R:W167	5.19	No	Yes	0	7	9
91	R:R:F194	R:R:M130	7.46	Yes	No	8	7	7
92	R:R:M130	R:R:W251	3.49	No	Yes	8	7	7
93	R:R:C131	R:R:M197	4.86	No	No	0	5	7
94	R:R:L133	R:R:Y295	4.69	No	Yes	0	8	9
95	R:R:L134	R:R:M197	4.24	No	No	0	7	7
96	R:R:I136	R:R:R140	6.26	No	Yes	2	9	9
97	R:R:I136	R:R:Y295	3.63	No	Yes	2	9	9
98	R:R:D139	R:R:Y150	5.75	No	Yes	0	9	8
99	R:R:R140	R:R:Y205	6.17	Yes	Yes	2	9	9
100	R:R:R140	R:R:Y295	5.14	Yes	Yes	2	9	9
101	R:R:F145	R:R:Y141	20.63	Yes	Yes	9	7	8
102	R:R:L204	R:R:Y141	9.38	Yes	Yes	0	7	8
103	R:R:H207	R:R:Y141	11.98	No	Yes	9	5	8
104	R:R:M208	R:R:Y141	3.59	No	Yes	0	9	8
105	R:R:T143	R:R:Y150	8.74	No	Yes	0	9	8
106	R:R:F145	R:R:I144	6.28	Yes	No	0	7	9
107	R:R:F145	R:R:H207	19.23	Yes	No	9	7	5
108	R:R:F145	R:R:L211	7.31	Yes	No	0	7	5
109	R:R:H152	R:R:R149	11.28	No	No	0	4	5
110	R:R:H151	R:R:Y150	6.53	No	Yes	0	4	8
111	R:R:M154	R:R:Y150	7.18	No	Yes	5	7	8
112	R:R:R158	R:R:T155	3.88	No	No	0	6	8
113	R:R:G160	R:R:S159	3.71	No	Yes	0	1	7
114	R:R:C173	R:R:F169	8.38	No	No	0	4	4
115	R:R:F177	R:R:I178	5.02	No	No	0	4	4
116	R:R:S183	R:R:Y180	10.17	No	No	0	4	3
117	R:R:E182	R:R:S181	7.19	No	No	0	4	2
118	R:R:S183	R:R:V186	4.85	No	No	0	4	4
119	R:R:I191	R:R:T259	7.6	No	No	0	4	4
120	R:R:M193	R:R:M197	4.33	No	No	0	4	7
121	R:R:F194	R:R:F195	5.36	Yes	No	0	7	4
122	R:R:F194	R:R:W251	3.01	Yes	Yes	8	7	7
123	R:R:F194	R:R:F255	26.79	Yes	No	0	7	5
124	R:R:F247	R:R:L198	4.87	No	No	0	8	6
125	R:R:L200	R:R:L204	4.15	No	Yes	0	5	7
126	R:R:L201	R:R:Y205	3.52	No	Yes	0	8	9
127	R:R:F247	R:R:L201	8.53	No	No	0	8	8
128	R:R:L244	R:R:V202	4.47	No	No	0	7	5
129	R:R:L243	R:R:Y205	5.86	No	Yes	2	8	9
130	R:R:L244	R:R:Y205	5.86	No	Yes	0	7	9
131	R:R:Y205	R:R:Y295	3.97	Yes	Yes	2	9	9
132	R:R:F209	R:R:R213	6.41	Yes	No	0	6	5
133	R:R:F209	R:R:G236	3.01	Yes	No	0	6	8
134	R:R:F209	R:R:V240	3.93	Yes	No	0	6	8
135	R:R:H215	R:R:L211	5.14	No	No	0	7	5
136	R:R:R213	R:R:S233	6.59	No	No	0	5	6
137	R:R:A220	R:R:R231	6.91	No	No	0	4	4
138	R:R:L222	R:R:P223	4.93	No	No	0	3	2
139	R:R:M234	R:R:V238	3.04	No	No	0	5	6
140	R:R:M242	R:R:T239	4.52	No	No	0	6	9
141	R:R:I294	R:R:L243	4.28	No	No	2	9	8
142	R:R:L243	R:R:Y295	5.86	No	Yes	2	8	9
143	R:R:F247	R:R:W251	8.02	No	Yes	0	8	7
144	R:R:C250	R:R:N287	9.45	No	No	0	8	9
145	R:R:I284	R:R:W251	10.57	No	Yes	0	7	7
146	R:R:N287	R:R:W251	9.04	No	Yes	0	9	7
147	R:R:P253	R:R:Y280	5.56	No	Yes	0	9	5
148	R:R:F254	R:R:F255	5.36	Yes	No	0	5	5
149	R:R:F254	R:R:L258	10.96	Yes	No	0	5	4
150	R:R:F254	R:R:F277	4.29	Yes	No	0	5	4
151	R:R:F254	R:R:I284	6.28	Yes	No	0	5	7
152	R:R:L256	R:R:T259	4.42	No	No	0	4	4
153	R:R:F273	R:R:L256	8.53	No	No	0	4	4
154	R:R:H257	R:R:L258	3.86	Yes	No	0	4	4
155	R:R:H257	R:R:M274	10.51	Yes	No	0	4	1
156	R:R:F277	R:R:H257	15.84	No	Yes	0	4	4
157	R:R:H257	R:R:Y280	3.27	Yes	Yes	0	4	5
158	R:R:L260	R:R:S263	3	Yes	No	3	3	4
159	R:R:C264	R:R:L260	4.76	Yes	Yes	3	3	3
160	R:R:C270	R:R:L260	3.17	No	Yes	3	2	3
161	R:R:F273	R:R:L260	6.09	No	Yes	0	4	3
162	R:R:C264	R:R:S263	3.44	Yes	No	3	3	4
163	R:R:C264	R:R:N267	6.3	Yes	No	3	3	3
164	R:R:C264	R:R:C270	7.28	Yes	No	3	3	2
165	R:R:P265	R:R:Q266	6.32	No	No	0	2	1
166	R:R:C270	R:R:N267	6.3	No	No	3	2	3
167	R:R:R272	R:R:Y269	4.12	No	No	0	4	4
168	R:R:F273	R:R:Y280	16.5	No	Yes	0	4	5
169	R:R:H276	R:R:S275	6.97	No	No	0	3	2
170	R:R:H276	R:R:M279	6.57	No	No	0	3	4
171	R:R:H276	R:R:Y280	8.71	No	Yes	0	3	5
172	R:R:M279	R:R:N278	9.82	No	No	0	4	3
173	R:R:M285	R:R:S288	6.13	Yes	Yes	1	6	9
174	R:R:D291	R:R:N287	10.77	No	No	0	9	9
175	R:R:L293	R:R:M290	4.24	No	No	0	6	6
176	R:R:D291	R:R:P292	3.22	No	No	0	9	9
177	R:R:I294	R:R:Y295	6.04	No	Yes	2	9	9
178	R:R:F297	R:R:R303	13.9	No	No	0	6	9
179	R:R:R298	R:R:R303	4.26	No	No	0	8	9
180	R:R:Q300	R:R:R303	11.68	No	No	0	5	9
181	R:R:F306	R:R:K307	8.69	No	No	0	6	5
182	R:R:L46	R:R:V289	2.98	No	No	0	6	6
183	R:R:L134	R:R:V138	2.98	No	No	0	7	7
184	R:R:L244	R:R:V240	2.98	No	No	0	7	8
185	R:R:N54	R:R:V57	2.96	Yes	No	0	9	9
186	R:R:L198	R:R:T248	2.95	No	No	0	6	5
187	R:R:L211	R:R:T214	2.95	No	No	0	5	5
188	R:R:I55	R:R:M83	2.92	No	No	0	5	7
189	R:R:M130	R:R:M193	2.89	No	No	0	7	4
190	R:R:M261	R:R:M274	2.89	No	No	0	4	1
191	R:R:I94	R:R:L98	2.85	No	No	0	5	4
192	R:R:A107	R:R:F110	2.77	No	Yes	0	6	3
193	R:R:A252	R:R:F194	2.77	No	Yes	0	5	7
194	R:R:A237	R:R:F209	2.77	No	Yes	0	7	6
195	R:R:E308	R:R:K63	2.7	No	No	0	5	5
196	R:R:N267	R:R:Q266	2.64	No	No	0	3	1
197	R:R:F43	R:R:V42	2.62	Yes	No	0	6	5
198	R:R:F177	R:R:V186	2.62	No	No	0	4	4
199	R:R:A81	R:R:W167	2.59	No	Yes	0	8	9
200	R:R:F118	R:R:T95	2.59	Yes	No	0	6	4
201	R:R:V142	R:R:Y150	2.52	No	Yes	0	6	8
202	R:R:M208	R:R:R140	2.48	No	Yes	0	9	9
203	R:R:F297	R:R:L293	2.44	No	No	0	6	6
204	R:R:I153	R:R:Y146	2.42	No	No	0	6	6
205	R:R:F145	R:R:Y146	2.06	Yes	No	0	7	6
206	R:R:C123	R:R:G174	1.96	No	No	0	5	6
207	R:R:A164	R:R:G165	1.95	No	No	0	4	4
208	R:R:A168	R:R:G165	1.95	No	No	0	3	4
209	R:R:G172	R:R:T171	1.82	No	No	0	3	3
210	R:R:G245	R:R:T248	1.82	No	No	0	5	5
211	R:R:G172	R:R:I175	1.76	No	No	0	3	3
212	R:R:G47	R:R:M285	1.75	No	Yes	0	6	6
213	R:R:A81	R:R:S129	1.71	No	No	0	8	9
214	R:R:A156	R:R:S159	1.71	No	Yes	0	2	7
215	R:R:C250	R:R:V246	1.71	No	No	0	8	6
216	R:R:A296	R:R:V75	1.7	No	No	0	8	8
217	R:R:G236	R:R:Q235	1.64	No	No	0	8	8
218	R:R:C311	R:R:I310	1.64	No	No	0	6	5
219	R:R:S125	R:R:S88	1.63	No	No	0	6	6
220	R:R:A60	R:R:I309	1.62	No	No	0	8	7
221	R:R:V176	R:R:V186	1.6	No	No	0	5	4
222	R:R:C189	R:R:L188	1.59	No	No	0	4	4
223	R:R:T248	R:R:V249	1.59	No	No	0	5	5
224	R:R:A137	R:R:L201	1.58	No	No	0	9	8
225	R:R:A137	R:R:L204	1.58	No	Yes	0	9	7
226	R:R:I166	R:R:S77	1.55	No	Yes	6	6	9
227	R:R:I166	R:R:S132	1.55	No	No	6	6	8
228	R:R:I49	R:R:V289	1.54	No	No	0	5	6
229	R:R:I58	R:R:V62	1.54	No	No	0	8	3
230	R:R:I61	R:R:V62	1.54	Yes	No	0	8	3
231	R:R:I206	R:R:V202	1.54	No	No	0	4	5
232	R:R:I206	R:R:V240	1.54	No	No	0	4	8
233	R:R:I49	R:R:T45	1.52	No	No	0	5	3
234	R:R:I114	R:R:T95	1.52	No	No	0	4	4
235	R:R:M290	R:R:V246	1.52	No	No	0	6	6
236	R:R:M234	R:R:T232	1.51	No	No	0	5	5
237	R:R:L204	R:R:S203	1.5	Yes	No	0	7	4
238	R:R:L44	R:R:V40	1.49	No	No	0	5	4
239	R:R:L190	R:R:V127	1.49	No	No	0	5	6
240	R:R:D119	R:R:S120	1.47	No	No	0	4	5
241	R:R:D108	R:R:V111	1.46	No	No	0	2	3
242	R:R:I187	R:R:M261	1.46	No	No	0	5	4
243	R:R:I309	R:R:L56	1.43	No	No	0	7	7
244	R:R:I187	R:R:L262	1.43	No	No	0	5	3
245	R:R:I206	R:R:L210	1.43	No	No	0	4	3
246	R:R:I96	R:R:N100	1.42	No	No	0	4	3
247	R:R:Q235	R:R:T232	1.42	No	No	0	8	5
248	R:R:E92	R:R:T93	1.41	No	No	0	6	6
249	R:R:E53	R:R:I49	1.37	No	No	0	8	5
250	R:R:R272	R:R:S275	1.32	No	No	0	4	2
251	R:R:R231	R:R:V216	1.31	No	No	0	4	6
252	R:R:R157	R:R:T155	1.29	No	No	0	4	8
253	R:R:S183	R:R:Y185	1.27	No	No	0	4	1
254	R:R:F306	R:R:I310	1.26	No	No	0	6	5
255	R:R:I153	R:R:R149	1.25	No	No	0	6	5
256	R:R:T184	R:R:Y185	1.25	No	No	0	3	1
257	R:R:L179	R:R:Y180	1.17	No	No	0	3	3
258	R:R:F110	R:R:H113	1.13	Yes	No	0	3	4
259	R:R:H215	R:R:R218	1.13	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F43	3.832	5	0	6
2	R:R:S50	4.135	6	1	8
3	R:R:N54	6.48333	6	1	9
4	R:R:I61	3.4825	4	4	8
5	R:R:L67	7.83	4	4	9
6	R:R:P70	4.105	4	5	6
7	R:R:Y72	6.032	5	4	8
8	R:R:F74	5.4725	4	0	8
9	R:R:S77	5.07	4	6	9
10	R:R:D82	8.4875	4	1	9
11	R:R:S86	5.0825	4	1	8
12	R:R:W91	8.1625	4	0	7
13	R:R:F110	5.3725	4	0	3
14	R:R:F118	5.38	4	0	6
15	R:R:R140	5.002	5	2	9
16	R:R:Y141	11.395	4	9	8
17	R:R:F145	11.102	5	9	7
18	R:R:Y150	5.815	6	5	8
19	R:R:S159	4.3425	4	0	7
20	R:R:W167	4.41	4	0	9
21	R:R:F194	9.078	5	8	7
22	R:R:L204	4.1525	4	0	7
23	R:R:Y205	5.076	5	2	9
24	R:R:F209	4.03	4	0	6
25	R:R:W251	6.915	6	8	7
26	R:R:F254	6.7225	4	0	5
27	R:R:H257	8.37	4	0	4
28	R:R:L260	4.255	4	3	3
29	R:R:C264	5.445	4	3	3
30	R:R:Y280	8.51	4	0	5
31	R:R:M285	4.642	5	1	6
32	R:R:S288	5.7775	4	1	9
33	R:R:Y295	4.88833	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F43	R:R:L281	22.315	3.65	Yes	No	0	6	3
2	R:R:L281	R:R:S89	24.4742	3	No	No	0	3	6
3	R:R:M285	R:R:S89	26.6094	6.13	Yes	No	0	6	6
4	R:R:M285	R:R:S50	30.3821	3.07	Yes	Yes	1	6	8
5	R:R:N54	R:R:S50	46.5484	4.47	Yes	Yes	1	9	8
6	R:R:N54	R:R:P292	95.9705	6.52	Yes	No	0	9	9
7	R:R:D291	R:R:P292	96.1711	3.22	No	No	0	9	9
8	R:R:D291	R:R:N287	96.4601	10.77	No	No	0	9	9
9	R:R:N287	R:R:W251	100	9.04	No	Yes	0	9	7
10	R:R:I284	R:R:W251	93.8915	10.57	No	Yes	0	7	7
11	R:R:F254	R:R:I284	92.7838	6.28	Yes	No	0	5	7
12	R:R:F254	R:R:L258	48.8843	10.96	Yes	No	0	5	4
13	R:R:H257	R:R:L258	47.4233	3.86	Yes	No	0	4	4
14	R:R:H257	R:R:Y280	78.8249	3.27	Yes	Yes	0	4	5
15	R:R:H276	R:R:Y280	24.8836	8.71	No	Yes	0	3	5
16	R:R:H276	R:R:M279	10.7561	6.57	No	No	0	3	4
17	R:R:F254	R:R:F277	48.8441	4.29	Yes	No	0	5	4
18	R:R:F277	R:R:H257	47.4233	15.84	No	Yes	0	4	4
19	R:R:F43	R:R:T93	11.318	5.19	Yes	No	0	6	6
20	R:R:S50	R:R:V289	11.31	3.23	Yes	No	0	8	6
21	R:R:M83	R:R:N54	56.6463	7.01	No	Yes	0	7	9
22	R:R:L51	R:R:M83	52.8415	4.24	No	No	0	6	7
23	R:R:L51	R:R:M87	50.9151	4.24	No	No	0	6	5
24	R:R:A79	R:R:N54	70.3163	3.13	No	Yes	0	9	9
25	R:R:F306	R:R:L56	12.5462	7.31	No	No	0	6	7
26	R:R:I309	R:R:L56	15.6446	1.43	No	No	0	7	7
27	R:R:A60	R:R:I309	24.8435	1.62	No	No	0	8	7
28	R:R:A60	R:R:T305	27.8777	3.36	No	No	0	8	7
29	R:R:N64	R:R:T305	30.8958	8.77	No	No	0	7	7
30	R:R:L67	R:R:N64	36.8839	12.36	Yes	No	0	9	7
31	R:R:I61	R:R:L67	33.9621	4.28	Yes	Yes	4	8	9
32	R:R:C76	R:R:I61	33.9862	3.27	No	Yes	0	7	8
33	R:R:C76	R:R:I58	34.532	3.27	No	No	0	7	8
34	R:R:A79	R:R:I58	69.5136	3.25	No	No	0	9	8
35	R:R:I61	R:R:V62	33.9862	1.54	Yes	No	0	8	3
36	R:R:I58	R:R:V62	34.532	1.54	No	No	0	8	3
37	R:R:I61	R:R:Y72	32.2764	4.84	Yes	Yes	4	8	8
38	R:R:P70	R:R:S159	14.1997	5.34	Yes	Yes	0	6	7
39	R:R:P70	R:R:Y150	34.2992	4.17	Yes	Yes	5	6	8
40	R:R:D139	R:R:Y150	35.5755	5.75	No	Yes	0	9	8
41	R:R:D139	R:R:M71	27.7412	4.16	No	No	0	9	9
42	R:R:M71	R:R:R140	28.8891	4.96	No	Yes	0	9	9
43	R:R:R140	R:R:Y205	26.5773	6.17	Yes	Yes	2	9	9
44	R:R:L201	R:R:Y205	58.5568	3.52	No	Yes	0	8	9
45	R:R:F247	R:R:L201	77.1954	8.53	No	No	0	8	8
46	R:R:F247	R:R:W251	80.7272	8.02	No	Yes	0	8	7
47	R:R:P70	R:R:S69	34.9334	3.56	Yes	No	0	6	7
48	R:R:D139	R:R:F74	18.165	4.78	No	Yes	0	9	8
49	R:R:F74	R:R:I163	11.5669	3.77	Yes	No	0	8	8
50	R:R:Y205	R:R:Y295	17.7717	3.97	Yes	Yes	2	9	9
51	R:R:L133	R:R:Y295	15.9978	4.69	No	Yes	0	8	9
52	R:R:L133	R:R:L78	14.2398	4.15	No	No	0	8	9
53	R:R:L78	R:R:S132	12.7709	6.01	No	No	0	9	8
54	R:R:S132	R:R:S77	10.0417	3.26	No	Yes	6	8	9
55	R:R:S77	R:R:W167	14.8017	6.18	Yes	Yes	0	9	9
56	R:R:M87	R:R:W91	48.9725	4.65	No	Yes	0	5	7
57	R:R:F118	R:R:W91	32.8383	10.02	Yes	Yes	0	6	7
58	R:R:F118	R:R:M121	13.6057	4.98	Yes	No	0	6	5
59	R:R:M121	R:R:S88	11.3903	6.13	No	No	0	5	6
60	R:R:I94	R:R:W91	13.6218	14.09	No	Yes	0	5	7
61	R:R:I94	R:R:L98	11.3903	2.85	No	No	0	5	4
62	R:R:F110	R:R:I114	11.3903	3.77	Yes	No	0	3	4
63	R:R:I114	R:R:T95	13.6137	1.52	No	No	0	4	4
64	R:R:F118	R:R:T95	15.7489	2.59	Yes	No	0	6	4
65	R:R:M130	R:R:M193	19.8908	2.89	No	No	0	7	4
66	R:R:M130	R:R:W251	17.7637	3.49	No	Yes	8	7	7
67	R:R:M193	R:R:M197	10.0738	4.33	No	No	0	4	7
68	R:R:F145	R:R:Y141	18.9035	20.63	Yes	Yes	9	7	8
69	R:R:L204	R:R:Y141	16.3188	9.38	Yes	Yes	0	7	8
70	R:R:A137	R:R:L204	19.0641	1.58	No	Yes	0	9	7
71	R:R:A137	R:R:L201	20.7256	1.58	No	No	0	9	8
72	R:R:M208	R:R:R140	10.8123	2.48	No	Yes	0	9	9
73	R:R:F273	R:R:L256	10.7481	8.53	No	No	0	4	4
74	R:R:F273	R:R:Y280	48.9806	16.5	No	Yes	0	4	5
75	R:R:L244	R:R:Y205	28.7125	5.86	No	Yes	0	7	9
76	R:R:F209	R:R:V240	16.5596	3.93	Yes	No	0	6	8
77	R:R:L244	R:R:V240	21.6969	2.98	No	No	0	7	8
78	R:R:C250	R:R:N287	16.1743	9.45	No	No	0	8	9
79	R:R:H257	R:R:M274	14.3121	10.51	Yes	No	0	4	1
80	R:R:F273	R:R:L260	35.3106	6.09	No	Yes	0	4	3
81	R:R:C264	R:R:L260	14.1515	4.76	Yes	Yes	3	3	3
82	R:R:C270	R:R:L260	14.1596	3.17	No	Yes	3	2	3
83	R:R:C264	R:R:N267	10.6598	6.3	Yes	No	3	3	3
84	R:R:C270	R:R:N267	10.6357	6.3	No	No	3	2	3
85	R:R:N267	R:R:Q266	14.2158	2.64	No	No	0	3	1
86	R:R:H276	R:R:S275	10.7561	6.97	No	No	0	3	2
87	R:R:C250	R:R:V246	14.2077	1.71	No	No	0	8	6
88	R:R:M290	R:R:V246	12.2251	1.52	No	No	0	6	6
89	R:R:L293	R:R:M290	10.2264	4.24	No	No	0	6	6
90	R:R:M261	R:R:M274	10.7561	2.89	No	No	0	4	1
91	R:R:S69	R:R:Y72	35.0056	6.36	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9K3H_nogp

PDB Summary
PDB	9K3H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	245
Number of Links	259
Number of Hubs	33
Number of Links mediated by Hubs	123
Number of Communities	9
Number of Nodes involved in Communities	36
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	32604
Length Of Smallest Path	3
Average Path Length	13.9874
Length of Longest Path	29
Minimum Path Strength	1.26
Average Path Strength	5.8699
Maximum Path Strength	17.125
Minimum Path Correlation	0.7
Average Path Correlation	0.944858
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	59.8129
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.1855
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P33032
Sequence	>9K3H_nogp_Chain_R I A V E V F L T L G V I S L L E N I L V I G A I V K N K N L H S P M Y F F V C S L A V A D M L V S M S S A W E T I T I Y L L N N K H L V I A D A F V R H I D N V F D S M I C I S V V A S M C S L L A I A V D R Y V T I F Y A L R Y H H I M T A R R S G A I I A G I W A F C T G C G I V F I L Y S E S T Y V I L C L I S M F F A M L F L L V S L Y I H M F L L A R T H V K R I A A L P G A S R T S M Q G A V T V T M L L G V F T V C W A P F F L H L T L M L S C P Q N L Y C S R F M S H F N M Y L I L I M C N S V M D P L I Y A F R S Q E M R K T F K E I I C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8INR	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.73	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8INR (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	α-MSH	Ca		2.73	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOD	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca	chim(NtGi1-Gs)/β1/γ2	2.59	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOD (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	PG-901	Ca		2.59	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	9K3H	A	Peptide	Melanocortin	MC₅	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.86	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3H (No Gprot)	A	Peptide	Melanocortin	MC₅	Homo sapiens	-	-		2.86	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K3H_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.