psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G22	R:R:Y136	4.35	No	Yes	0	4	6
2	L:L:D25	L:L:T23	11.56	No	No	2	4	4
3	L:L:T23	R:R:S211	4.8	No	No	2	4	4
4	L:L:N24	R:R:K57	8.39	Yes	Yes	1	6	4
5	L:L:N24	R:R:N305	6.81	Yes	No	0	6	4
6	L:L:N24	R:R:Y308	9.3	Yes	Yes	1	6	4
7	L:L:N24	R:R:D309	12.12	Yes	No	1	6	5
8	L:L:D25	R:R:R209	15.48	No	Yes	2	4	4
9	L:L:D25	R:R:S211	4.42	No	No	2	4	4
10	L:L:A26	R:R:K50	4.82	No	Yes	0	7	3
11	L:L:E27	R:R:S202	8.62	No	Yes	2	5	1
12	L:L:E27	R:R:S204	5.75	No	No	0	5	6
13	L:L:E27	R:R:R209	12.79	No	Yes	2	5	4
14	L:L:D28	R:R:R54	8.34	No	Yes	0	6	4
15	L:L:C29	L:L:L31	3.17	No	No	7	9	7
16	L:L:C29	L:L:C55	7.28	No	No	7	9	9
17	L:L:C29	R:R:K50	3.23	No	Yes	0	9	3
18	L:L:C30	L:L:S32	3.44	Yes	No	0	9	5
19	L:L:C30	L:L:L50	3.17	Yes	No	4	9	4
20	L:L:C30	L:L:P58	3.77	Yes	No	4	9	4
21	L:L:C30	L:L:C71	7.28	Yes	No	4	9	9
22	L:L:C30	R:R:L47	3.17	Yes	No	4	9	4
23	L:L:C55	L:L:L31	3.17	No	No	7	9	7
24	L:L:S32	R:R:E45	4.31	No	No	0	5	2
25	L:L:P73	L:L:V33	3.53	Yes	No	0	7	7
26	L:L:L70	L:L:T34	7.37	Yes	No	0	7	5
27	L:L:K36	L:L:Q35	5.42	No	No	0	4	4
28	L:L:L70	L:L:P37	4.93	Yes	Yes	0	7	4
29	L:L:P37	L:L:W78	5.4	Yes	Yes	0	4	9
30	L:L:I82	L:L:P37	3.39	No	Yes	0	7	4
31	L:L:I38	L:L:P39	3.39	Yes	No	0	7	8
32	L:L:I38	L:L:I42	4.42	Yes	No	0	7	4
33	L:L:I38	R:R:F44	5.02	Yes	Yes	0	7	2
34	L:L:R85	L:L:Y41	12.35	No	No	0	4	3
35	L:L:L86	L:L:Y41	7.03	No	No	0	8	3
36	L:L:I42	L:L:T64	4.56	No	Yes	0	4	9
37	L:L:I42	L:L:L65	2.85	No	No	0	4	4
38	L:L:F62	L:L:V43	5.24	Yes	No	0	9	8
39	L:L:T64	L:L:V43	3.17	Yes	No	0	9	8
40	L:L:L86	L:L:V43	4.47	No	No	0	8	8
41	L:L:R44	L:L:T89	3.88	No	No	0	3	3
42	L:L:H47	L:L:N45	3.83	No	No	0	4	5
43	L:L:F46	L:L:T63	19.46	No	No	0	8	4
44	L:L:F62	L:L:Y48	3.09	Yes	No	0	9	3
45	L:L:I83	L:L:Y48	13.3	Yes	No	0	5	3
46	L:L:K52	L:L:L49	2.82	Yes	No	0	6	9
47	L:L:L50	L:L:P58	19.7	No	No	4	4	4
48	L:L:L50	L:L:V61	7.45	No	No	4	4	8
49	L:L:I51	L:L:K52	2.91	No	Yes	0	2	6
50	L:L:I51	L:L:V57	3.07	No	No	0	2	5
51	L:L:K52	R:R:S202	3.06	Yes	Yes	0	6	1
52	L:L:K52	R:R:S203	4.59	Yes	No	0	6	2
53	L:L:D53	R:R:Q200	6.53	Yes	No	2	5	3
54	L:L:D53	R:R:S202	7.36	Yes	Yes	2	5	1
55	L:L:D53	R:R:R209	13.1	Yes	Yes	2	5	4
56	L:L:D53	R:R:I213	12.59	Yes	No	2	5	4
57	L:L:C55	L:L:R56	6.96	No	No	0	9	4
58	L:L:R56	R:R:N290	3.62	No	No	0	4	3
59	L:L:C71	L:L:P58	3.77	No	No	4	9	4
60	L:L:A59	L:L:P74	5.61	No	No	0	9	7
61	L:L:F62	L:L:V60	10.49	Yes	No	0	9	7
62	L:L:V60	L:L:V79	3.21	No	No	0	7	9
63	L:L:I83	L:L:V60	3.07	Yes	No	0	5	7
64	L:L:Q69	L:L:V61	4.3	Yes	No	4	6	8
65	L:L:V61	R:R:L47	4.47	No	No	4	8	4
66	L:L:F62	L:L:L70	6.09	Yes	Yes	0	9	7
67	L:L:F62	L:L:I82	5.02	Yes	No	0	9	7
68	L:L:Q69	L:L:T63	18.43	Yes	No	0	6	4
69	L:L:R68	L:L:T64	5.17	No	Yes	0	5	9
70	L:L:R68	R:R:F44	6.41	No	Yes	0	5	2
71	L:L:Q69	R:R:S46	2.89	Yes	No	0	6	4
72	L:L:Q69	R:R:L47	9.32	Yes	No	4	6	4
73	L:L:L70	R:R:F44	6.09	Yes	Yes	0	7	2
74	L:L:P73	L:L:Q76	7.9	Yes	Yes	0	7	3
75	L:L:P77	L:L:Q76	3.16	No	Yes	6	3	3
76	L:L:Q76	L:L:W78	30.67	Yes	Yes	6	3	9
77	L:L:Q76	L:L:V79	12.89	Yes	No	6	3	9
78	L:L:P77	L:L:W78	4.05	No	Yes	6	3	9
79	L:L:V79	L:L:W78	4.9	No	Yes	6	9	9
80	L:L:Q84	L:L:R81	5.84	No	No	0	4	4
81	L:L:R81	L:L:R85	3.2	No	No	0	4	4
82	L:L:I82	L:L:L86	4.28	No	No	0	7	8
83	L:L:S90	L:L:T89	3.2	No	No	0	3	3
84	R:R:F44	R:R:T42	3.89	Yes	No	0	2	4
85	R:R:C48	R:R:K50	9.7	No	Yes	0	6	3
86	R:R:C298	R:R:C48	7.28	No	No	0	5	6
87	R:R:K50	R:R:V53	3.04	Yes	No	0	3	4
88	R:R:K50	R:R:S301	3.06	Yes	No	0	3	3
89	R:R:K50	R:R:N305	4.2	Yes	No	0	3	4
90	R:R:D52	R:R:V53	2.92	No	No	8	3	4
91	R:R:D52	R:R:K302	13.83	No	No	8	3	3
92	R:R:K302	R:R:V53	7.59	No	No	8	3	4
93	R:R:F56	R:R:F60	7.5	No	Yes	0	4	5
94	R:R:F56	R:R:I306	13.82	No	No	0	4	2
95	R:R:D309	R:R:F56	3.58	No	No	0	5	4
96	R:R:K57	R:R:L61	4.23	Yes	Yes	1	4	6
97	R:R:A118	R:R:K57	3.21	No	Yes	1	5	4
98	R:R:D309	R:R:K57	8.3	No	Yes	1	5	4
99	R:R:F60	R:R:L61	3.65	Yes	Yes	1	5	6
100	R:R:F60	R:R:M64	4.98	Yes	Yes	1	5	5
101	R:R:F60	R:R:V310	5.24	Yes	No	0	5	5
102	R:R:F60	R:R:S313	6.61	Yes	No	1	5	5
103	R:R:L61	R:R:Y65	11.72	Yes	No	0	6	7
104	R:R:A118	R:R:L61	3.15	No	Yes	1	5	6
105	R:R:I67	R:R:M64	2.92	No	Yes	0	5	5
106	R:R:I68	R:R:M64	10.2	No	Yes	0	6	5
107	R:R:M64	R:R:S313	6.13	Yes	No	1	5	5
108	R:R:A115	R:R:Y65	4	No	No	0	7	7
109	R:R:Y312	R:R:Y65	6.95	Yes	No	0	5	7
110	R:R:C316	R:R:I68	3.27	Yes	No	0	7	6
111	R:R:C69	R:R:L111	3.17	No	No	0	6	8
112	R:R:C69	R:R:P112	3.77	No	No	0	6	9
113	R:R:C320	R:R:V71	5.12	No	No	0	7	5
114	R:R:L109	R:R:L73	4.15	No	No	0	4	5
115	R:R:L74	R:R:L78	4.15	No	No	0	4	6
116	R:R:A101	R:R:N76	4.69	No	Yes	0	9	9
117	R:R:D104	R:R:N76	12.12	No	Yes	9	9	9
118	R:R:I105	R:R:N76	4.25	No	Yes	0	7	9
119	R:R:N76	R:R:P323	9.77	Yes	No	9	9	9
120	R:R:L97	R:R:V79	4.47	No	No	0	7	9
121	R:R:A101	R:R:V79	3.39	No	No	0	9	9
122	R:R:F333	R:R:T82	3.89	Yes	Yes	5	8	6
123	R:R:D336	R:R:T82	2.89	No	Yes	0	5	6
124	R:R:L337	R:R:T82	5.9	No	Yes	5	6	6
125	R:R:L340	R:R:T82	5.9	No	Yes	0	5	6
126	R:R:L89	R:R:Y83	3.52	No	No	0	7	7
127	R:R:D94	R:R:Y83	10.34	No	No	0	8	7
128	R:R:L98	R:R:Y83	19.93	No	No	0	6	7
129	R:R:F86	R:R:Y85	9.28	Yes	No	10	5	4
130	R:R:K339	R:R:Y85	8.36	No	No	10	4	4
131	R:R:L340	R:R:Y85	5.86	No	No	0	5	4
132	R:R:F86	R:R:R88	12.83	Yes	No	0	5	6
133	R:R:D336	R:R:F86	16.72	No	Yes	0	5	5
134	R:R:F86	R:R:K339	7.44	Yes	No	10	5	4
135	R:R:K87	R:R:L89	4.23	No	No	0	6	7
136	R:R:K90	R:R:R88	11.14	No	No	0	6	6
137	R:R:D94	R:R:R88	3.57	No	No	0	8	6
138	R:R:T91	R:R:T93	3.14	No	No	0	7	7
139	R:R:M92	R:R:Y96	11.97	Yes	Yes	1	6	7
140	R:R:D153	R:R:M92	13.86	No	Yes	0	8	6
141	R:R:M92	R:R:S175	7.67	Yes	No	1	6	8
142	R:R:D153	R:R:T93	10.12	No	No	0	8	7
143	R:R:S175	R:R:T95	4.8	No	No	0	8	5
144	R:R:C149	R:R:Y96	9.41	No	Yes	1	6	7
145	R:R:I150	R:R:Y96	4.84	No	Yes	1	8	7
146	R:R:S175	R:R:Y96	8.9	No	Yes	1	8	7
147	R:R:S178	R:R:Y96	5.09	No	Yes	1	5	7
148	R:R:A327	R:R:L97	4.73	No	No	5	7	7
149	R:R:F333	R:R:L97	4.87	Yes	No	5	8	7
150	R:R:L146	R:R:N99	4.12	Yes	No	0	8	9
151	R:R:C179	R:R:N99	11.02	No	No	0	7	9
152	R:R:N99	R:R:W183	3.39	No	Yes	0	9	9
153	R:R:L100	R:R:L146	5.54	No	Yes	0	9	8
154	R:R:L100	R:R:L147	5.54	No	Yes	0	9	8
155	R:R:A103	R:R:S142	3.42	No	No	0	8	6
156	R:R:C319	R:R:D104	7.78	No	No	0	8	9
157	R:R:D104	R:R:P323	3.22	No	No	9	9	9
158	R:R:I105	R:R:L109	2.85	No	No	0	7	4
159	R:R:L106	R:R:S139	4.5	No	No	0	6	8
160	R:R:F107	R:R:L111	8.53	Yes	No	1	6	8
161	R:R:F107	R:R:Y136	6.19	Yes	Yes	1	6	6
162	R:R:F107	R:R:S139	5.28	Yes	No	0	6	8
163	R:R:F107	R:R:F140	5.36	Yes	Yes	1	6	7
164	R:R:F107	R:R:Y312	4.13	Yes	Yes	1	6	5
165	R:R:C316	R:R:F107	2.79	Yes	Yes	1	7	6
166	R:R:C319	R:R:F107	2.79	No	Yes	0	8	6
167	R:R:I132	R:R:T110	3.04	Yes	No	0	5	6
168	R:R:I135	R:R:T110	3.04	No	No	0	4	6
169	R:R:T110	R:R:Y136	3.75	No	Yes	0	6	6
170	R:R:C316	R:R:L111	4.76	Yes	No	1	7	8
171	R:R:F113	R:R:F124	9.65	No	Yes	3	6	7
172	R:R:F113	R:R:F128	6.43	No	No	3	6	5
173	R:R:F113	R:R:I132	7.54	No	Yes	3	6	5
174	R:R:W114	R:R:W122	14.99	No	Yes	3	6	9
175	R:R:I132	R:R:W114	4.7	Yes	No	3	5	6
176	R:R:F133	R:R:W114	9.02	Yes	No	0	5	6
177	R:R:K120	R:R:Y116	4.78	No	No	0	4	3
178	R:R:S117	R:R:W122	12.36	No	Yes	0	5	9
179	R:R:M208	R:R:S121	3.07	No	No	0	5	5
180	R:R:F124	R:R:W122	15.03	Yes	Yes	3	7	9
181	R:R:C129	R:R:W122	5.22	No	Yes	3	9	9
182	R:R:I132	R:R:W122	5.87	Yes	Yes	3	5	9
183	R:R:C210	R:R:W122	5.22	No	Yes	3	9	9
184	R:R:F124	R:R:F128	9.65	Yes	No	3	7	5
185	R:R:K130	R:R:V126	3.04	No	No	0	7	2
186	R:R:F128	R:R:I132	7.54	No	Yes	3	5	5
187	R:R:C129	R:R:C210	7.28	No	No	3	9	9
188	R:R:I135	R:R:L131	7.14	No	No	0	4	4
189	R:R:E193	R:R:F133	4.66	Yes	Yes	0	4	5
190	R:R:F133	R:R:S197	11.89	Yes	No	0	5	5
191	R:R:F133	R:R:L212	8.53	Yes	No	0	5	5
192	R:R:K137	R:R:Y136	16.72	Yes	Yes	0	5	6
193	R:R:Y136	R:R:Y312	5.96	Yes	Yes	1	6	5
194	R:R:F141	R:R:K137	9.93	Yes	Yes	0	7	5
195	R:R:K137	R:R:S190	3.06	Yes	No	0	5	7
196	R:R:E193	R:R:K137	17.55	Yes	Yes	0	4	5
197	R:R:K137	R:R:Q227	10.85	Yes	No	0	5	5
198	R:R:M138	R:R:W183	4.65	Yes	Yes	0	5	9
199	R:R:A186	R:R:M138	3.22	No	Yes	0	7	5
200	R:R:M138	R:R:T187	4.52	Yes	No	0	5	3
201	R:R:M138	R:R:S190	3.07	Yes	No	0	5	7
202	R:R:F140	R:R:F141	4.29	Yes	Yes	1	7	7
203	R:R:F140	R:R:M144	4.98	Yes	Yes	1	7	7
204	R:R:F140	R:R:Q227	4.68	Yes	No	0	7	5
205	R:R:F140	R:R:G231	3.01	Yes	No	1	7	5
206	R:R:F141	R:R:L189	10.96	Yes	No	1	7	5
207	R:R:F141	R:R:I230	5.02	Yes	No	1	7	4
208	R:R:S142	R:R:W183	12.36	No	Yes	0	6	9
209	R:R:G143	R:R:L146	3.42	No	Yes	0	9	8
210	R:R:G231	R:R:M144	3.49	No	Yes	1	5	7
211	R:R:M144	R:R:P235	5.03	Yes	No	0	7	9
212	R:R:M144	R:R:R318	9.93	Yes	Yes	1	7	9
213	R:R:I182	R:R:L145	4.28	Yes	No	0	6	5
214	R:R:L145	R:R:L185	4.15	No	No	0	5	4
215	R:R:I182	R:R:L146	5.71	Yes	Yes	0	6	8
216	R:R:L147	R:R:R318	7.29	Yes	Yes	1	8	9
217	R:R:L147	R:R:N322	5.49	Yes	No	1	8	9
218	R:R:L147	R:R:Y326	7.03	Yes	Yes	1	8	9
219	R:R:I152	R:R:L148	2.85	No	No	0	5	7
220	R:R:C149	R:R:S178	3.44	No	No	1	6	5
221	R:R:C149	R:R:I182	4.91	No	Yes	1	6	6
222	R:R:I150	R:R:R154	3.76	No	No	1	8	9
223	R:R:I150	R:R:Y326	4.84	No	Yes	1	8	9
224	R:R:M239	R:R:S151	7.67	No	No	1	7	9
225	R:R:C242	R:R:S151	3.44	No	No	0	7	9
226	R:R:S151	R:R:Y243	3.82	No	Yes	1	9	8
227	R:R:C242	R:R:I152	3.27	No	No	0	7	5
228	R:R:R154	R:R:Y243	8.23	No	Yes	1	9	8
229	R:R:R154	R:R:Y326	6.17	No	Yes	1	9	9
230	R:R:V159	R:R:Y155	12.62	No	Yes	12	7	8
231	R:R:V245	R:R:Y155	6.31	No	Yes	12	3	8
232	R:R:I158	R:R:I246	4.42	No	Yes	0	8	8
233	R:R:V159	R:R:V245	6.41	No	No	12	7	3
234	R:R:T249	R:R:V159	6.35	No	No	0	5	7
235	R:R:Q160	R:R:S163	5.78	No	No	0	6	4
236	R:R:H167	R:R:R166	4.51	No	No	0	3	4
237	R:R:I182	R:R:S178	3.1	Yes	No	1	6	5
238	R:R:I230	R:R:L189	4.28	No	No	1	4	5
239	R:R:I191	R:R:P192	3.39	No	No	0	4	8
240	R:R:I191	R:R:L195	2.85	No	No	0	4	3
241	R:R:E193	R:R:P192	3.14	Yes	No	11	4	8
242	R:R:I223	R:R:P192	5.08	No	No	11	4	8
243	R:R:E193	R:R:I223	6.83	Yes	No	11	4	4
244	R:R:L195	R:R:Y196	3.52	No	No	0	3	4
245	R:R:T214	R:R:Y196	12.48	No	No	13	5	4
246	R:R:A219	R:R:Y196	4	No	No	13	3	4
247	R:R:D198	R:R:Q200	6.53	No	No	2	4	3
248	R:R:D198	R:R:I213	4.2	No	No	2	4	4
249	R:R:L199	R:R:M208	2.83	No	No	0	4	5
250	R:R:C210	R:R:L199	7.94	No	No	0	9	4
251	R:R:I213	R:R:Q200	6.86	No	No	2	4	3
252	R:R:R209	R:R:S202	10.54	Yes	Yes	2	4	1
253	R:R:E205	R:R:Q206	3.82	No	No	0	4	5
254	R:R:R209	R:R:S211	6.59	Yes	No	2	4	4
255	R:R:F220	R:R:L212	6.09	No	No	0	4	5
256	R:R:I223	R:R:L212	5.71	No	No	0	4	5
257	R:R:A219	R:R:T214	5.03	No	No	13	3	5
258	R:R:E215	R:R:H216	9.85	No	No	0	6	2
259	R:R:F291	R:R:I221	3.77	No	No	0	1	2
260	R:R:Q224	R:R:V283	2.87	No	No	0	5	5
261	R:R:Q224	R:R:T287	11.34	No	No	0	5	4
262	R:R:Q227	R:R:Y279	10.15	No	Yes	0	5	6
263	R:R:M228	R:R:N280	2.8	No	No	0	5	8
264	R:R:L284	R:R:M228	4.24	No	No	0	5	5
265	R:R:I230	R:R:V229	4.61	No	No	0	4	4
266	R:R:F232	R:R:L233	3.65	Yes	No	0	8	4
267	R:R:F232	R:R:L236	3.65	Yes	No	0	8	6
268	R:R:F232	R:R:Q276	3.51	Yes	No	0	8	8
269	R:R:F232	R:R:L277	3.65	Yes	No	0	8	5
270	R:R:F232	R:R:N280	13.29	Yes	No	0	8	8
271	R:R:P235	R:R:V234	3.53	No	No	0	9	5
272	R:R:F272	R:R:L236	8.53	Yes	No	0	9	6
273	R:R:I273	R:R:L236	7.14	No	No	0	5	6
274	R:R:M239	R:R:Y243	7.18	No	Yes	1	7	8
275	R:R:F272	R:R:M239	7.46	Yes	No	1	9	7
276	R:R:I246	R:R:Y243	3.63	Yes	Yes	1	8	8
277	R:R:I265	R:R:Y243	12.09	No	Yes	1	7	8
278	R:R:V268	R:R:Y243	5.05	No	Yes	0	8	8
279	R:R:V269	R:R:Y243	5.05	No	Yes	0	7	8
280	R:R:R248	R:R:V245	3.92	No	No	0	4	3
281	R:R:I246	R:R:L250	2.85	Yes	Yes	0	8	8
282	R:R:I246	R:R:I265	2.94	Yes	No	1	8	7
283	R:R:I247	R:R:L251	2.85	No	No	1	4	5
284	R:R:I247	R:R:I262	4.42	No	No	1	4	5
285	R:R:I247	R:R:I265	8.83	No	No	1	4	7
286	R:R:I262	R:R:L250	4.28	No	Yes	0	5	8
287	R:R:I262	R:R:L251	2.85	No	No	1	5	5
288	R:R:E257	R:R:F256	9.33	No	No	0	5	3
289	R:R:E257	R:R:R258	5.82	No	No	0	5	6
290	R:R:K263	R:R:N259	5.6	No	No	0	5	5
291	R:R:K260	R:R:V264	3.04	No	No	0	7	7
292	R:R:I329	R:R:V264	7.68	No	No	0	6	7
293	R:R:L325	R:R:V268	5.96	No	No	0	7	8
294	R:R:I273	R:R:V269	3.07	No	No	0	5	7
295	R:R:L325	R:R:V271	4.47	No	No	0	7	6
296	R:R:F272	R:R:Q276	11.71	Yes	No	1	9	8
297	R:R:F272	R:R:R318	6.41	Yes	Yes	1	9	9
298	R:R:F275	R:R:V274	3.93	Yes	No	0	7	5
299	R:R:F275	R:R:L314	3.65	Yes	No	0	7	7
300	R:R:F275	R:R:V317	7.87	Yes	No	0	7	5
301	R:R:F275	R:R:V321	3.93	Yes	No	0	7	6
302	R:R:Q276	R:R:R318	14.02	No	Yes	1	8	9
303	R:R:P278	R:R:T311	3.5	No	No	0	9	6
304	R:R:L314	R:R:P278	3.28	No	No	0	7	9
305	R:R:V283	R:R:Y279	8.83	No	Yes	1	5	6
306	R:R:Y279	R:R:Y308	12.91	Yes	Yes	1	6	4
307	R:R:T311	R:R:Y279	4.99	No	Yes	0	6	6
308	R:R:Y279	R:R:Y312	15.89	Yes	Yes	1	6	5
309	R:R:A315	R:R:Y279	4	No	Yes	0	8	6
310	R:R:A307	R:R:V282	3.39	No	No	0	5	5
311	R:R:V282	R:R:Y308	3.79	No	Yes	0	5	4
312	R:R:T311	R:R:V282	7.93	No	No	0	6	5
313	R:R:V283	R:R:Y308	5.05	No	Yes	1	5	4
314	R:R:Q286	R:R:Y308	12.4	No	Yes	0	5	4
315	R:R:L300	R:R:S296	6.01	No	No	0	3	1
316	R:R:L300	R:R:T297	2.95	No	No	0	3	5
317	R:R:L300	R:R:L304	4.15	No	No	0	3	6
318	R:R:C316	R:R:Y312	6.72	Yes	Yes	1	7	5
319	R:R:C320	R:R:V317	3.42	No	No	0	7	5
320	R:R:N322	R:R:R318	13.26	No	Yes	1	9	9
321	R:R:N322	R:R:Y326	6.98	No	Yes	1	9	9
322	R:R:F324	R:R:F328	7.5	No	No	0	6	7
323	R:R:A327	R:R:F333	4.16	No	Yes	5	7	8
324	R:R:F328	R:R:L337	7.31	No	No	0	7	6
325	R:R:G330	R:R:K332	3.49	No	No	0	8	7
326	R:R:F333	R:R:L337	6.09	Yes	No	5	8	6
327	R:R:N335	R:R:R334	3.62	No	No	0	5	8
328	R:R:K339	R:R:K342	8.62	No	No	0	4	5
329	L:L:A26	R:R:R54	2.77	No	Yes	0	7	4
330	L:L:D28	R:R:K50	2.77	No	Yes	0	6	3
331	R:R:L108	R:R:L73	2.77	No	No	0	5	5
332	R:R:L340	R:R:L81	2.77	No	No	0	5	3
333	R:R:D198	R:R:K130	2.77	No	No	0	4	7
334	R:R:H216	R:R:T214	2.74	No	No	0	2	5
335	R:R:C242	R:R:Y155	2.69	No	Yes	0	7	8
336	R:R:R54	R:R:S204	2.64	Yes	No	0	4	6
337	R:R:R166	R:R:V162	2.62	No	No	0	4	6
338	L:L:R66	L:L:T64	2.59	No	Yes	0	5	9
339	R:R:E299	R:R:Q303	2.55	No	No	0	5	3
340	R:R:V102	R:R:W183	2.45	No	Yes	0	5	9
341	R:R:N255	R:R:R258	2.41	No	No	0	4	6
342	R:R:Q252	R:R:R248	2.34	No	No	0	5	4
343	R:R:Q160	R:R:Y155	2.25	No	Yes	0	6	8
344	R:R:G75	R:R:P323	2.03	No	No	0	7	9
345	R:R:C320	R:R:G72	1.96	No	No	0	7	8
346	L:L:P73	L:L:P74	1.95	Yes	No	0	7	7
347	L:L:A72	L:L:P73	1.87	No	Yes	0	9	7
348	R:R:A119	R:R:P62	1.87	No	No	0	4	6
349	R:R:G181	R:R:V180	1.84	No	No	0	2	3
350	L:L:G67	L:L:T63	1.82	No	No	0	5	4
351	L:L:G67	L:L:T64	1.82	No	Yes	0	5	9
352	L:L:G40	L:L:I38	1.76	No	Yes	0	1	7
353	R:R:G181	R:R:I184	1.76	No	No	0	2	4
354	R:R:G330	R:R:I329	1.76	No	No	0	8	6
355	R:R:G75	R:R:L74	1.71	No	No	0	7	4
356	R:R:A207	R:R:S202	1.71	No	Yes	0	1	1
357	R:R:A207	R:R:S204	1.71	No	No	0	1	6
358	R:R:G281	R:R:L284	1.71	No	No	0	6	5
359	R:R:A289	R:R:S296	1.71	No	No	0	3	1
360	L:L:A59	L:L:V57	1.7	No	No	0	9	5
361	R:R:A101	R:R:V80	1.7	No	No	0	9	7
362	R:R:A164	R:R:V156	1.7	No	No	0	5	6
363	L:L:K36	L:L:P37	1.67	No	Yes	0	4	4
364	R:R:L61	R:R:P62	1.64	Yes	No	0	6	6
365	R:R:S296	R:R:S301	1.63	No	No	0	1	3
366	R:R:A157	R:R:I158	1.62	No	No	0	8	8
367	R:R:A119	R:R:K120	1.61	No	No	0	4	4
368	R:R:V225	R:R:V229	1.6	No	No	0	4	4
369	R:R:V264	R:R:V268	1.6	No	No	0	7	8
370	R:R:V270	R:R:V274	1.6	No	No	0	4	5
371	R:R:A134	R:R:L194	1.58	No	No	0	5	4
372	R:R:A238	R:R:L148	1.58	No	No	0	7	7
373	R:R:A261	R:R:L250	1.58	No	Yes	0	7	8
374	R:R:A285	R:R:L304	1.58	No	No	0	5	6
375	R:R:A253	R:R:N255	1.56	No	No	0	3	4
376	R:R:I152	R:R:V156	1.54	No	No	0	5	6
377	R:R:I184	R:R:V188	1.54	No	No	0	4	4
378	R:R:I266	R:R:V270	1.54	No	No	0	4	4
379	R:R:M92	R:R:V171	1.52	Yes	No	0	6	6
380	R:R:I221	R:R:T222	1.52	No	No	0	2	1
381	R:R:F124	R:R:G125	1.51	Yes	No	0	7	7
382	R:R:K176	R:R:T95	1.5	No	No	0	3	5
383	R:R:L284	R:R:V288	1.49	No	No	0	5	4
384	R:R:N335	R:R:V331	1.48	No	No	0	5	5
385	R:R:I63	R:R:I67	1.47	No	No	0	5	5
386	R:R:L172	R:R:T95	1.47	No	No	0	2	5
387	R:R:I84	R:R:L81	1.43	No	No	0	2	3
388	R:R:K130	R:R:L194	1.41	No	No	0	7	4
389	R:R:E218	R:R:T222	1.41	No	No	0	1	1
390	R:R:E299	R:R:T297	1.41	No	No	0	5	5
391	R:R:A226	R:R:F141	1.39	No	Yes	0	3	7
392	R:R:H127	R:R:V126	1.38	No	No	0	1	2
393	R:R:H167	R:R:V171	1.38	No	No	0	3	6
394	L:L:E80	L:L:I83	1.37	No	Yes	0	5	5
395	L:L:I83	L:L:Q87	1.37	Yes	No	0	5	5
396	R:R:L250	R:R:N255	1.37	Yes	No	0	8	4
397	L:L:H47	L:L:L49	1.29	No	No	0	4	9
398	L:L:K52	R:R:R201	1.24	Yes	No	0	6	1
399	R:R:K51	R:R:R54	1.24	No	Yes	0	3	4
400	R:R:H165	R:R:R168	1.13	No	No	0	5	7
401	R:R:F328	R:R:R334	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:N24	9.155	4	1	6
2	L:L:C30	4.166	5	4	9
3	L:L:P37	3.8475	4	0	4
4	L:L:I38	3.6475	4	0	7
5	L:L:K52	2.924	5	0	6
6	L:L:D53	9.895	4	2	5
7	L:L:F62	5.986	5	0	9
8	L:L:T64	3.462	5	0	9
9	L:L:Q69	8.735	4	4	6
10	L:L:L70	6.12	4	0	7
11	L:L:P73	3.8125	4	0	7
12	L:L:Q76	13.655	4	6	3
13	L:L:W78	11.255	4	6	9
14	L:L:I83	4.7775	4	0	5
15	R:R:F44	5.3525	4	0	2
16	R:R:K50	4.40286	7	0	3
17	R:R:R54	3.7475	4	0	4
18	R:R:K57	6.0325	4	1	4
19	R:R:F60	5.596	5	1	5
20	R:R:L61	4.878	5	1	6
21	R:R:M64	6.0575	4	1	5
22	R:R:N76	7.7075	4	9	9
23	R:R:T82	4.645	4	5	6
24	R:R:F86	11.5675	4	10	5
25	R:R:M92	8.755	4	1	6
26	R:R:Y96	8.042	5	1	7
27	R:R:F107	5.01	7	1	6
28	R:R:W122	9.78167	6	3	9
29	R:R:F124	8.96	4	3	7
30	R:R:I132	5.738	5	3	5
31	R:R:F133	8.525	4	0	5
32	R:R:Y136	7.394	5	1	6
33	R:R:K137	11.622	5	0	5
34	R:R:M138	3.865	4	0	5
35	R:R:F140	4.464	5	1	7
36	R:R:F141	6.318	5	1	7
37	R:R:M144	5.8575	4	1	7
38	R:R:L146	4.6975	4	0	8
39	R:R:L147	6.3375	4	1	8
40	R:R:Y155	5.9675	4	12	8
41	R:R:I182	4.5	4	1	6
42	R:R:W183	5.7125	4	0	9
43	R:R:E193	8.045	4	11	4
44	R:R:S202	6.258	5	2	1
45	R:R:R209	11.7	5	2	4
46	R:R:F232	5.55	5	0	8
47	R:R:Y243	6.43571	7	1	8
48	R:R:I246	3.46	4	1	8
49	R:R:L250	2.52	4	0	8
50	R:R:F272	8.5275	4	1	9
51	R:R:F275	4.845	4	0	7
52	R:R:Y279	9.46167	6	1	6
53	R:R:Y308	8.69	5	1	4
54	R:R:Y312	7.93	5	1	5
55	R:R:C316	4.385	4	1	7
56	R:R:R318	10.182	5	1	9
57	R:R:Y326	6.255	4	1	9
58	R:R:F333	4.7525	4	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E27	R:R:R209	11.2114	12.79	No	Yes	2	5	4
2	L:L:E27	R:R:S204	55.3979	5.75	No	No	0	5	6
3	R:R:R54	R:R:S204	100	2.64	Yes	No	0	4	6
4	L:L:D28	R:R:R54	50.3972	8.34	No	Yes	0	6	4
5	L:L:D28	R:R:K50	50.5127	2.77	No	Yes	0	6	3
6	R:R:K50	R:R:N305	99.7063	4.2	Yes	No	0	3	4
7	L:L:N24	R:R:N305	99.6212	6.81	Yes	No	0	6	4
8	L:L:N24	R:R:Y308	91.4009	9.3	Yes	Yes	1	6	4
9	R:R:Y279	R:R:Y308	85.5243	12.91	Yes	Yes	1	6	4
10	R:R:Y279	R:R:Y312	27.8015	15.89	Yes	Yes	1	6	5
11	L:L:A26	R:R:R54	50.3972	2.77	No	Yes	0	7	4
12	L:L:A26	R:R:K50	50.5127	4.82	No	Yes	0	7	3
13	L:L:E27	R:R:S202	43.7137	8.62	No	Yes	2	5	1
14	R:R:A207	R:R:S204	44.2035	1.71	No	No	0	1	6
15	R:R:A207	R:R:S202	43.7182	1.71	No	Yes	0	1	1
16	L:L:Q69	L:L:T63	13.2389	18.43	Yes	No	0	6	4
17	L:L:G67	L:L:T63	15.6247	1.82	No	No	0	5	4
18	L:L:G67	L:L:T64	16.8149	1.82	No	Yes	0	5	9
19	L:L:T64	L:L:V43	21.3553	3.17	Yes	No	0	9	8
20	L:L:F62	L:L:V43	22.3807	5.24	Yes	No	0	9	8
21	L:L:F62	L:L:V60	24.4486	10.49	Yes	No	0	9	7
22	L:L:V60	L:L:V79	30.0789	3.21	No	No	0	7	9
23	L:L:Q76	L:L:V79	31.1374	12.89	Yes	No	6	3	9
24	L:L:P73	L:L:Q76	56.4278	7.9	Yes	Yes	0	7	3
25	L:L:P73	L:L:P74	59.7432	1.95	Yes	No	0	7	7
26	L:L:A59	L:L:P74	60.8447	5.61	No	No	0	9	7
27	L:L:A59	L:L:V57	61.9444	1.7	No	No	0	9	5
28	L:L:I51	L:L:V57	63.0424	3.07	No	No	0	2	5
29	L:L:I51	L:L:K52	64.1385	2.91	No	Yes	0	2	6
30	L:L:K52	R:R:S202	70.6528	3.06	Yes	Yes	0	6	1
31	L:L:Q76	L:L:W78	23.0506	30.67	Yes	Yes	6	3	9
32	L:L:P37	L:L:W78	22.0852	5.4	Yes	Yes	0	4	9
33	L:L:L70	L:L:P37	11.7774	4.93	Yes	Yes	0	7	4
34	L:L:D53	R:R:S202	17.6639	7.36	Yes	Yes	2	5	1
35	L:L:D53	R:R:Q200	12.2046	6.53	Yes	No	2	5	3
36	L:L:D53	R:R:I213	12.2046	12.59	Yes	No	2	5	4
37	R:R:P278	R:R:T311	10.2245	3.5	No	No	0	9	6
38	R:R:C319	R:R:F107	22.1309	2.79	No	Yes	0	8	6
39	R:R:C319	R:R:D104	21.6267	7.78	No	No	0	8	9
40	R:R:D104	R:R:N76	18.9535	12.12	No	Yes	9	9	9
41	R:R:A101	R:R:N76	16.4862	4.69	No	Yes	0	9	9
42	R:R:A101	R:R:V79	15.4366	3.39	No	No	0	9	9
43	R:R:L97	R:R:V79	14.9091	4.47	No	No	0	7	9
44	R:R:F333	R:R:L97	13.8264	4.87	Yes	No	5	8	7
45	R:R:F140	R:R:M144	50.9435	4.98	Yes	Yes	1	7	7
46	R:R:M144	R:R:R318	49.8025	9.93	Yes	Yes	1	7	9
47	R:R:L147	R:R:R318	13.5318	7.29	Yes	Yes	1	8	9
48	R:R:I150	R:R:Y326	16.0814	4.84	No	Yes	1	8	9
49	R:R:I150	R:R:Y96	15.9444	4.84	No	Yes	1	8	7
50	R:R:T110	R:R:Y136	10.8756	3.75	No	Yes	0	6	6
51	R:R:E193	R:R:K137	11.2857	17.55	Yes	Yes	0	4	5
52	R:R:D198	R:R:Q200	10.4663	6.53	No	No	2	4	3
53	R:R:D198	R:R:K130	17.4489	2.77	No	No	0	4	7
54	R:R:D198	R:R:I213	10.4663	4.2	No	No	2	4	4
55	R:R:K137	R:R:Q227	16.9277	10.85	Yes	No	0	5	5
56	R:R:F272	R:R:R318	22.8563	6.41	Yes	Yes	1	9	9
57	R:R:F272	R:R:M239	21.4628	7.46	Yes	No	1	9	7
58	R:R:M239	R:R:Y243	12.9685	7.18	No	Yes	1	7	8
59	R:R:F107	R:R:Y312	19.2776	4.13	Yes	Yes	1	6	5
60	R:R:Q227	R:R:Y279	56.9544	10.15	No	Yes	0	5	6
61	R:R:F140	R:R:Q227	43.2569	4.68	Yes	No	0	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G22	R:R:Y136	4.35	0	No	Yes	4	6	0	1
L:L:T23	R:R:S211	4.8	2	No	No	4	4	0	1
L:L:N24	R:R:K57	8.39	1	Yes	Yes	6	4	0	1
L:L:N24	R:R:N305	6.81	1	Yes	No	6	4	0	1
L:L:N24	R:R:Y308	9.3	1	Yes	Yes	6	4	0	1
L:L:N24	R:R:D309	12.12	1	Yes	No	6	5	0	1
L:L:D25	R:R:R209	15.48	2	No	Yes	4	4	0	1
L:L:D25	R:R:S211	4.42	2	No	No	4	4	0	1
L:L:A26	R:R:K50	4.82	0	No	Yes	7	3	0	1
L:L:E27	R:R:S202	8.62	2	No	Yes	5	1	0	1
L:L:E27	R:R:S204	5.75	2	No	No	5	6	0	1
L:L:E27	R:R:R209	12.79	2	No	Yes	5	4	0	1
L:L:D28	R:R:R54	8.34	0	No	Yes	6	4	0	1
L:L:C29	R:R:K50	3.23	7	No	Yes	9	3	0	1
L:L:C30	R:R:L47	3.17	4	Yes	No	9	4	0	1
L:L:S32	R:R:E45	4.31	0	No	No	5	2	0	1
L:L:I38	R:R:F44	5.02	0	Yes	Yes	7	2	0	1
L:L:K52	R:R:S202	3.06	0	Yes	Yes	6	1	0	1
L:L:K52	R:R:S203	4.59	0	Yes	No	6	2	0	1
L:L:D53	R:R:Q200	6.53	2	Yes	No	5	3	0	1
L:L:D53	R:R:S202	7.36	2	Yes	Yes	5	1	0	1
L:L:D53	R:R:R209	13.1	2	Yes	Yes	5	4	0	1
L:L:D53	R:R:I213	12.59	2	Yes	No	5	4	0	1
L:L:R56	R:R:N290	3.62	0	No	No	4	3	0	1
L:L:V61	R:R:L47	4.47	4	No	No	8	4	0	1
L:L:R68	R:R:F44	6.41	0	No	Yes	5	2	0	1
L:L:Q69	R:R:S46	2.89	4	Yes	No	6	4	0	1
L:L:Q69	R:R:L47	9.32	4	Yes	No	6	4	0	1
L:L:L70	R:R:F44	6.09	0	Yes	Yes	7	2	0	1
R:R:F44	R:R:T42	3.89	0	Yes	No	2	4	1	2
R:R:C48	R:R:K50	9.7	0	No	Yes	6	3	2	1
R:R:K50	R:R:V53	3.04	0	Yes	No	3	4	1	2
R:R:K50	R:R:S301	3.06	0	Yes	No	3	3	1	2
R:R:K50	R:R:N305	4.2	0	Yes	No	3	4	1	1
R:R:D309	R:R:F56	3.58	1	No	No	5	4	1	2
R:R:K57	R:R:L61	4.23	1	Yes	Yes	4	6	1	2
R:R:A118	R:R:K57	3.21	1	No	Yes	5	4	2	1
R:R:D309	R:R:K57	8.3	1	No	Yes	5	4	1	1
R:R:A118	R:R:L61	3.15	1	No	Yes	5	6	2	2
R:R:F107	R:R:Y136	6.19	1	Yes	Yes	6	6	2	1
R:R:F107	R:R:Y312	4.13	1	Yes	Yes	6	5	2	2
R:R:T110	R:R:Y136	3.75	0	No	Yes	6	6	2	1
R:R:K137	R:R:Y136	16.72	0	Yes	Yes	5	6	2	1
R:R:Y136	R:R:Y312	5.96	1	Yes	Yes	6	5	1	2
R:R:D198	R:R:Q200	6.53	2	No	No	4	3	2	1
R:R:D198	R:R:I213	4.2	2	No	No	4	4	2	1
R:R:I213	R:R:Q200	6.86	2	No	No	4	3	1	1
R:R:R209	R:R:S202	10.54	2	Yes	Yes	4	1	1	1
R:R:R209	R:R:S211	6.59	2	Yes	No	4	4	1	1
R:R:V283	R:R:Y279	8.83	1	No	Yes	5	6	2	2
R:R:Y279	R:R:Y308	12.91	1	Yes	Yes	6	4	2	1
R:R:Y279	R:R:Y312	15.89	1	Yes	Yes	6	5	2	2
R:R:V282	R:R:Y308	3.79	0	No	Yes	5	4	2	1
R:R:V283	R:R:Y308	5.05	1	No	Yes	5	4	2	1
R:R:Q286	R:R:Y308	12.4	0	No	Yes	5	4	2	1
L:L:A26	R:R:R54	2.77	0	No	Yes	7	4	0	1
L:L:D28	R:R:K50	2.77	0	No	Yes	6	3	0	1
R:R:R54	R:R:S204	2.64	0	Yes	No	4	6	1	1
R:R:A207	R:R:S202	1.71	0	No	Yes	1	1	2	1
R:R:A207	R:R:S204	1.71	0	No	No	1	6	2	1
L:L:K52	R:R:R201	1.24	0	Yes	No	6	1	0	1
R:R:K51	R:R:R54	1.24	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KO2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.79
Number of Linked Nodes	339
Number of Links	401
Number of Hubs	58
Number of Links mediated by Hubs	221
Number of Communities	13
Number of Nodes involved in Communities	99
Number of Links involved in Communities	132

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	159912
Length Of Smallest Path	3
Average Path Length	20.9393
Length of Longest Path	46
Minimum Path Strength	1.37
Average Path Strength	6.08957
Maximum Path Strength	19.285
Minimum Path Correlation	0.7
Average Path Correlation	0.952477
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	49.8076
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.1895
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • CCR chemokine receptor binding • signaling receptor binding • CCR7 chemokine receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • CCR10 chemokine receptor binding • molecular function activator activity • signaling receptor activator activity • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • dendritic cell differentiation • mature conventional dendritic cell differentiation • leukocyte differentiation • cell surface receptor signaling pathway • CCL19-activated CCR7 signaling pathway • response to cytokine • response to chemokine • chemokine (C-C motif) ligand 19 signaling pathway • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • C-C chemokine receptor CCR7 signaling pathway • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • cell chemotaxis • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • myeloid dendritic cell chemotaxis • immune system process • mononuclear cell migration • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • interleukin-1 production • regulation of interleukin-1 beta production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of interleukin-1 beta production • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of interleukin-1 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • interleukin-1 beta production • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • regulation of signaling • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • regulation of cell communication • positive regulation of signaling • regulation of cellular component organization • cell projection organization • regulation of cell projection assembly • regulation of cell projection organization • regulation of cellular component biogenesis • cellular component biogenesis • cellular component organization • cellular component assembly • cellular component organization or biogenesis • cell projection assembly • regulation of localization • import into cell • positive regulation of cellular component organization • transport • vesicle-mediated transport • localization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of transport • endocytosis • receptor-mediated endocytosis • eosinophil chemotaxis • granulocyte migration • eosinophil migration • granulocyte chemotaxis • phospholipase C/protein kinase C signal transduction • positive regulation of phospholipase C/protein kinase C signal transduction • regulation of leukocyte activation • regulation of cell activation • positive regulation of leukocyte cell-cell adhesion • lymphocyte activation • leukocyte cell-cell adhesion • leukocyte activation • positive regulation of cell-cell adhesion • positive regulation of lymphocyte activation • positive regulation of cell activation • cell adhesion • cell-cell adhesion • T cell activation • positive regulation of leukocyte activation • regulation of immune system process • regulation of cell-cell adhesion • positive regulation of immune system process • positive regulation of T cell activation • positive regulation of cell adhesion • regulation of cell adhesion • cell activation • regulation of T cell activation • lymphocyte costimulation • regulation of leukocyte cell-cell adhesion • T cell costimulation • regulation of lymphocyte activation • regulation of cell motility • positive regulation of cell motility • positive regulation of cell population proliferation • lymphocyte proliferation • regulation of leukocyte proliferation • positive regulation of lymphocyte proliferation • positive regulation of T cell proliferation • regulation of cell population proliferation • mononuclear cell proliferation • positive regulation of leukocyte proliferation • leukocyte proliferation • positive regulation of mononuclear cell proliferation • T cell proliferation • regulation of lymphocyte proliferation • regulation of T cell proliferation • regulation of mononuclear cell proliferation • response to nitric oxide • regulation of small GTPase mediated signal transduction • Rac protein signal transduction • regulation of Rac protein signal transduction • positive regulation of Rac protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • immune response • regulation of Cdc42 protein signal transduction • regulation of Rho protein signal transduction • Rho protein signal transduction • Cdc42 protein signal transduction • positive regulation of glycoprotein metabolic process • positive regulation of protein metabolic process • carbohydrate derivative metabolic process • regulation of primary metabolic process • protein metabolic process • regulation of glycoprotein biosynthetic process • positive regulation of glycoprotein biosynthetic process • carbohydrate derivative biosynthetic process • regulation of protein metabolic process • glycoprotein biosynthetic process • primary metabolic process • glycoprotein metabolic process • regulation of glycoprotein metabolic process • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • regulation of alpha-beta T cell activation • positive regulation of T cell differentiation • regulation of cell development • positive regulation of immune response • regulation of T-helper cell differentiation • alpha-beta T cell activation • positive regulation of CD4-positive, alpha-beta T cell differentiation • T-helper cell differentiation • positive regulation of cell development • T-helper 1 type immune response • regulation of T-helper 1 type immune response • immune effector process • regulation of T-helper 1 cell differentiation • positive regulation of alpha-beta T cell differentiation • regulation of developmental process • CD4-positive, alpha-beta T cell differentiation • positive regulation of T-helper cell differentiation • regulation of T cell differentiation • alpha-beta T cell differentiation • T cell activation involved in immune response • positive regulation of cell differentiation • leukocyte activation involved in immune response • positive regulation of immune effector process • regulation of CD4-positive, alpha-beta T cell activation • regulation of immune effector process • regulation of leukocyte differentiation • regulation of cell differentiation • lymphocyte differentiation • cell activation involved in immune response • positive regulation of T-helper 1 cell differentiation • positive regulation of developmental process • T cell differentiation • regulation of adaptive immune response • positive regulation of alpha-beta T cell activation • regulation of immune response • regulation of CD4-positive, alpha-beta T cell differentiation • regulation of alpha-beta T cell differentiation • positive regulation of CD4-positive, alpha-beta T cell activation • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • alpha-beta T cell activation involved in immune response • positive regulation of hemopoiesis • CD4-positive, alpha-beta T cell activation • lymphocyte activation involved in immune response • regulation of lymphocyte differentiation • regulation of multicellular organismal development • T cell differentiation involved in immune response • adaptive immune response • T-helper 1 cell differentiation • regulation of hemopoiesis • positive regulation of leukocyte differentiation • positive regulation of lymphocyte differentiation • regulation of interleukin-12 production • interleukin-12 production • positive regulation of interleukin-12 production • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • regulation of granulocyte chemotaxis • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • anatomical structure maturation • cell maturation • developmental maturation • regulation of leukocyte apoptotic process • dendritic cell apoptotic process • negative regulation of dendritic cell apoptotic process • negative regulation of programmed cell death • leukocyte apoptotic process • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of cellular process • regulation of dendritic cell apoptotic process • apoptotic process • programmed cell death • dendritic cell dendrite assembly • positive regulation of dendritic cell dendrite assembly • plasma membrane bounded cell projection assembly • positive regulation of cell projection organization • regulation of dendritic cell dendrite assembly • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • response to external biotic stimulus • calcium ion transmembrane import into cytosol • monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • transmembrane transport • release of sequestered calcium ion into cytosol • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • regulation of non-canonical NF-kappaB signal transduction • non-canonical NF-kappaB signal transduction • positive regulation of non-canonical NF-kappaB signal transduction • immunological synapse formation • cell-cell recognition • cell recognition • response to virus • establishment of lymphocyte polarity • establishment of T cell polarity • establishment or maintenance of cell polarity • establishment of cell polarity • inflammatory response • regulation of dendritic cell antigen processing and presentation • positive regulation of dendritic cell antigen processing and presentation • positive regulation of antigen processing and presentation • antigen processing and presentation • regulation of antigen processing and presentation • dendritic cell antigen processing and presentation • regulation of tumor necrosis factor production • positive regulation of tumor necrosis factor superfamily cytokine production • tumor necrosis factor superfamily cytokine production • positive regulation of tumor necrosis factor production • tumor necrosis factor production • regulation of tumor necrosis factor superfamily cytokine production • cellular response to virus • chemokine (C-C motif) ligand 21 binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-C motif chemokine 19 receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine (C-C motif) ligand 19 binding • C-C motif chemokine 21 receptor activity • thymic T cell selection • T cell differentiation in thymus • negative thymic T cell selection • negative T cell selection • T cell selection • pseudopodium assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • pseudopodium organization • regulation of cell-substrate adhesion • cell-substrate adhesion • positive regulation of cell-matrix adhesion • cell-matrix adhesion • positive regulation of cell-substrate adhesion • regulation of cell-matrix adhesion • regulation of type II interferon production • type II interferon production • regulation of humoral immune response • positive regulation of humoral immune response • immune response-regulating cell surface receptor signaling pathway • positive regulation of T cell receptor signaling pathway • regulation of antigen receptor-mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of T cell receptor signaling pathway • T cell receptor signaling pathway • antigen receptor-mediated signaling pathway • activation of immune response • positive regulation of antigen receptor-mediated signaling pathway • CCL21-activated CCR7 signaling pathway • chemokine (C-C motif) ligand 21 signaling pathway • lymphocyte migration into lymphoid organs • lymphocyte migration • lymphocyte migration into lymph node • ruffle organization • positive regulation of T cell costimulation • regulation of T cell costimulation • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal-level homeostasis • homeostasis of number of cells • positive regulation of dendritic cell chemotaxis • positive regulation of mononuclear cell migration • regulation of mononuclear cell migration • regulation of dendritic cell chemotaxis • positive regulation of acute inflammatory response to antigenic stimulus • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • positive regulation of acute inflammatory response • inflammatory response to antigenic stimulus • positive regulation of hypersensitivity • positive regulation of inflammatory response • regulation of response to stress • acute inflammatory response • hypersensitivity • regulation of hypersensitivity • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • positive regulation of inflammatory response to antigenic stimulus • positive regulation of defense response • regulation of acute inflammatory response • calcium-mediated signaling • positive regulation of immunological synapse formation • regulation of immunological synapse formation • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • regulation of protein-containing complex assembly • positive regulation of protein-containing complex assembly • positive regulation of protein polymerization • protein-containing complex assembly • actin filament-based process • regulation of actin filament polymerization • protein polymerization • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • actin filament polymerization • protein-containing complex organization • positive regulation of cytoskeleton organization • regulation of actin polymerization or depolymerization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of protein polymerization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • positive regulation of actin filament polymerization • cytoskeleton organization • regulation of anatomical structure size • filopodium assembly • regulation of filopodium assembly • positive regulation of filopodium assembly • negative regulation of interleukin-12 production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • cell surface • external side of plasma membrane • mitochondrion
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	CCL19
UniProt	Q99731
Sequence	>9KO2_nogp_Chain_L G T N D A E D C C L S V T Q K P I P G Y I V R N F H Y L L I K D G C R V P A V V F T T L R G R Q L C A P P D Q P W V E R I I Q R L Q R T S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P32248
Sequence	>9KO2_nogp_Chain_R T L F E S L C S K K D V R N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F K R L K T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K S W V F G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q A V S A H R H R A R V L L I S K L S C V G I W I L A T V L S I P E L L Y S D L Q R S S S E Q A M R C S L I T E H V E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A R N F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F S T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K F R N D L F K L F K D L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6QZH	A	Protein	Chemokine	CCR7	Homo sapiens	-	PubChem 136165388; Na	-	2.1	2019-09-04	doi.org/10.1016/j.cell.2019.07.028
	9KO2	A	Protein	Chemokine	CCR7	Homo sapiens	CCL19	-	Gi1/β1	2.98	2025-11-26	To be published
	9KO2 (No Gprot)	A	Protein	Chemokine	CCR7	Homo sapiens	CCL19	-		2.98	2025-11-26	To be published
	9KO4	A	Protein	Chemokine	CCR7	Homo sapiens	CCL21	-	Gi1/β1/γ2	3.3	2025-11-26	To be published
	9KO4 (No Gprot)	A	Protein	Chemokine	CCR7	Homo sapiens	CCL21	-		3.3	2025-11-26	To be published
	9KO6	A	Protein	Chemokine	CCR7	Homo sapiens	CCL19	-	-	3.3	2025-11-26	To be published
	9L16	A	Protein	Chemokine	CCR7	Homo sapiens	CCL21	-	-	3.5	2025-12-17	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KO2_nogp.zip

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