psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G27	L:L:S24	3.71	No	No	0	5	5
2	L:L:S24	R:R:N305	2.98	No	No	0	5	4
3	L:L:S24	R:R:Y308	7.63	No	Yes	0	5	4
4	L:L:D25	R:R:W114	4.47	Yes	Yes	1	6	6
5	L:L:D25	R:R:F133	5.97	Yes	Yes	1	6	5
6	L:L:D25	R:R:Y136	14.94	Yes	Yes	1	6	6
7	L:L:D25	R:R:Y308	3.45	Yes	Yes	1	6	4
8	L:L:A28	R:R:K57	4.82	No	Yes	0	7	4
9	L:L:Q29	L:L:S54	5.78	Yes	No	4	5	6
10	L:L:C57	L:L:Q29	6.1	Yes	Yes	4	9	5
11	L:L:Q29	R:R:S202	7.22	Yes	No	4	5	1
12	L:L:Q29	R:R:Q206	10.24	Yes	No	4	5	5
13	L:L:D30	R:R:L47	10.86	No	Yes	0	7	4
14	L:L:C31	L:L:C57	7.28	No	Yes	0	9	9
15	L:L:C31	R:R:K50	3.23	No	No	0	9	3
16	L:L:A61	L:L:C32	3.61	No	No	0	9	9
17	L:L:C32	L:L:L63	3.17	No	Yes	6	9	8
18	L:L:C32	L:L:C75	7.28	No	No	6	9	9
19	L:L:L33	R:R:C48	7.94	No	No	0	8	6
20	L:L:L33	R:R:S301	9.01	No	No	0	8	3
21	L:L:K34	R:R:E45	6.75	No	No	0	5	2
22	L:L:K34	R:R:S296	7.65	No	No	0	5	1
23	L:L:I59	L:L:Y35	6.04	No	No	0	5	7
24	L:L:D77	L:L:Y35	24.14	Yes	No	0	8	7
25	L:L:S36	R:R:F44	3.96	No	No	0	6	2
26	L:L:S36	R:R:E45	4.31	No	No	0	6	2
27	L:L:R38	R:R:F44	10.69	No	No	0	5	2
28	L:L:K39	L:L:W82	16.24	No	Yes	0	3	8
29	L:L:I40	L:L:P41	3.39	No	Yes	0	7	7
30	L:L:F64	L:L:I40	3.77	No	No	0	9	7
31	L:L:I40	L:L:W82	7.05	No	Yes	0	7	8
32	L:L:P41	L:L:V44	5.3	Yes	No	0	7	4
33	L:L:R46	L:L:R67	11.73	No	No	0	3	5
34	L:L:K92	L:L:R46	4.95	No	No	0	4	3
35	L:L:P96	L:L:S47	7.13	No	No	0	4	7
36	L:L:I62	L:L:Y48	3.63	No	Yes	3	8	9
37	L:L:F64	L:L:Y48	3.09	No	Yes	0	9	9
38	L:L:M87	L:L:Y48	17.96	No	Yes	3	6	9
39	L:L:L90	L:L:Y48	8.21	No	Yes	0	7	9
40	L:L:R49	R:R:S203	9.22	No	No	0	5	2
41	L:L:C57	L:L:Q51	3.05	Yes	No	0	9	9
42	L:L:E52	R:R:Q200	8.92	No	No	0	5	3
43	L:L:P53	L:L:P60	11.69	No	No	0	5	5
44	L:L:P53	R:R:E215	3.14	No	No	0	5	6
45	L:L:C57	L:L:S54	3.44	Yes	No	4	9	6
46	L:L:S54	R:R:S211	4.89	No	No	0	6	4
47	L:L:G56	L:L:L55	3.42	No	No	0	6	7
48	L:L:L55	R:R:L212	5.54	No	No	0	7	5
49	L:L:I59	L:L:S58	3.1	No	No	0	5	5
50	L:L:S58	R:R:N290	7.45	No	No	0	5	3
51	L:L:I59	L:L:P60	3.39	No	No	0	5	5
52	L:L:P60	R:R:V217	3.53	No	No	0	5	2
53	L:L:I62	L:L:P78	6.77	No	No	0	8	8
54	L:L:I62	L:L:M87	5.83	No	No	3	8	6
55	L:L:C75	L:L:L63	6.35	No	Yes	6	9	8
56	L:L:L63	R:R:L47	12.46	Yes	Yes	6	8	4
57	L:L:F64	L:L:L86	7.31	No	No	0	9	5
58	L:L:L65	L:L:P66	4.93	No	No	0	4	9
59	L:L:P66	L:L:Q71	4.74	No	Yes	0	9	5
60	L:L:E73	L:L:P66	3.14	No	No	0	6	9
61	L:L:K68	L:L:Q71	9.49	No	Yes	0	5	5
62	L:L:K68	R:R:D30	5.53	No	No	0	5	4
63	L:L:K68	R:R:I33	13.09	No	No	0	5	5
64	L:L:Q71	L:L:S70	8.66	Yes	No	0	5	6
65	L:L:Q71	R:R:Y41	19.16	Yes	Yes	0	5	8
66	L:L:A72	R:R:Y41	4	No	Yes	0	3	8
67	L:L:E73	R:R:L47	5.3	No	Yes	0	6	4
68	L:L:L74	R:R:Y41	3.52	No	Yes	0	6	8
69	L:L:L74	R:R:S46	3	No	No	0	6	4
70	L:L:C75	R:R:L47	3.17	No	Yes	6	9	4
71	L:L:A76	L:L:V83	3.39	No	Yes	0	8	9
72	L:L:D77	L:L:P78	6.44	Yes	No	0	8	8
73	L:L:D77	L:L:K79	5.53	Yes	No	0	8	4
74	L:L:D77	L:L:E80	15.59	Yes	No	0	8	4
75	L:L:E80	L:L:W82	15.27	No	Yes	3	4	8
76	L:L:E80	L:L:V83	5.7	No	Yes	3	4	9
77	L:L:V83	L:L:W82	11.03	Yes	Yes	3	9	8
78	L:L:M87	L:L:V83	3.04	No	Yes	3	6	9
79	L:L:K92	L:L:P94	16.73	No	No	0	4	2
80	L:L:P94	L:L:T93	3.5	No	No	0	2	3
81	L:L:P96	L:L:S95	3.56	No	No	0	4	2
82	R:R:D35	R:R:Y32	4.6	No	No	0	6	7
83	R:R:G34	R:R:I33	3.53	No	No	7	5	5
84	R:R:I33	R:R:T38	9.12	No	No	7	5	5
85	R:R:G34	R:R:T38	3.64	No	No	7	5	5
86	R:R:D40	R:R:Y41	3.45	No	Yes	0	6	8
87	R:R:D40	R:R:T42	14.45	No	No	0	6	4
88	R:R:C298	R:R:C48	7.28	No	No	0	5	6
89	R:R:K50	R:R:V53	3.04	No	No	0	3	4
90	R:R:K50	R:R:N305	5.6	No	No	0	3	4
91	R:R:K51	R:R:R54	4.95	No	No	0	3	4
92	R:R:E205	R:R:K51	10.8	No	No	0	4	3
93	R:R:K57	R:R:V53	3.04	Yes	No	0	4	4
94	R:R:K302	R:R:V53	4.55	No	No	0	3	4
95	R:R:R209	R:R:R54	3.2	No	No	0	4	4
96	R:R:F56	R:R:F60	8.57	Yes	Yes	1	4	5
97	R:R:F56	R:R:I306	20.09	Yes	No	0	4	2
98	R:R:D309	R:R:F56	5.97	No	Yes	1	5	4
99	R:R:F56	R:R:V310	3.93	Yes	No	1	4	5
100	R:R:K57	R:R:L61	7.05	Yes	Yes	1	4	6
101	R:R:D309	R:R:K57	13.83	No	Yes	1	5	4
102	R:R:F60	R:R:M64	8.71	Yes	No	1	5	5
103	R:R:F60	R:R:V310	7.87	Yes	No	1	5	5
104	R:R:F60	R:R:S313	6.61	Yes	No	1	5	5
105	R:R:L61	R:R:Y65	3.52	Yes	Yes	1	6	7
106	R:R:D309	R:R:L61	5.43	No	Yes	1	5	6
107	R:R:A119	R:R:P62	3.74	No	No	0	4	6
108	R:R:M64	R:R:S313	6.13	No	No	1	5	5
109	R:R:L111	R:R:Y65	9.38	Yes	Yes	1	8	7
110	R:R:Y312	R:R:Y65	2.98	Yes	Yes	1	5	7
111	R:R:S313	R:R:Y65	5.09	No	Yes	1	5	7
112	R:R:C316	R:R:Y65	6.72	No	Yes	1	7	7
113	R:R:C316	R:R:I68	4.91	No	No	0	7	6
114	R:R:I68	R:R:V317	3.07	No	No	0	6	5
115	R:R:C69	R:R:L73	4.76	No	No	0	6	5
116	R:R:C320	R:R:V71	3.42	No	Yes	0	7	5
117	R:R:C320	R:R:G72	3.92	No	No	0	7	8
118	R:R:I105	R:R:L73	5.71	No	No	0	7	5
119	R:R:L108	R:R:L73	4.15	No	No	0	5	5
120	R:R:A101	R:R:N76	4.69	No	No	0	9	9
121	R:R:D104	R:R:N76	14.81	No	No	0	9	9
122	R:R:N76	R:R:P323	14.66	No	No	0	9	9
123	R:R:F341	R:R:L78	3.65	No	No	0	5	6
124	R:R:A101	R:R:V79	3.39	No	No	0	9	9
125	R:R:I84	R:R:V80	3.07	No	No	0	2	7
126	R:R:L340	R:R:L81	9.69	No	No	0	5	3
127	R:R:L337	R:R:T82	7.37	No	No	0	6	6
128	R:R:L340	R:R:T82	5.9	No	No	0	5	6
129	R:R:L89	R:R:Y83	4.69	No	No	0	7	7
130	R:R:D94	R:R:Y83	9.2	No	No	0	8	7
131	R:R:L98	R:R:Y83	28.13	No	No	0	6	7
132	R:R:F86	R:R:Y85	8.25	Yes	Yes	5	5	4
133	R:R:K339	R:R:Y85	5.97	No	Yes	5	4	4
134	R:R:L340	R:R:Y85	8.21	No	Yes	0	5	4
135	R:R:D343	R:R:Y85	12.64	No	Yes	0	4	4
136	R:R:F86	R:R:R88	6.41	Yes	Yes	5	5	6
137	R:R:D336	R:R:F86	8.36	No	Yes	5	5	5
138	R:R:F86	R:R:K339	6.2	Yes	No	5	5	4
139	R:R:D94	R:R:R88	9.53	No	Yes	0	8	6
140	R:R:K332	R:R:R88	12.38	No	Yes	0	7	6
141	R:R:D336	R:R:R88	14.29	No	Yes	5	5	6
142	R:R:L89	R:R:T95	2.95	No	No	0	7	5
143	R:R:K176	R:R:L89	8.46	No	No	0	3	7
144	R:R:T91	R:R:T93	3.14	No	No	0	7	7
145	R:R:M92	R:R:Y96	5.99	Yes	Yes	2	6	7
146	R:R:D153	R:R:M92	13.86	No	Yes	0	8	6
147	R:R:M92	R:R:V171	4.56	Yes	No	0	6	6
148	R:R:M92	R:R:S175	7.67	Yes	No	2	6	8
149	R:R:D153	R:R:T93	11.56	No	No	0	8	7
150	R:R:D94	R:R:F333	4.78	No	No	0	8	8
151	R:R:S175	R:R:T95	4.8	No	No	0	8	5
152	R:R:L146	R:R:Y96	3.52	Yes	Yes	0	8	7
153	R:R:C149	R:R:Y96	14.79	No	Yes	0	6	7
154	R:R:I150	R:R:Y96	4.84	No	Yes	2	8	7
155	R:R:S175	R:R:Y96	3.82	No	Yes	2	8	7
156	R:R:S178	R:R:Y96	5.09	No	Yes	0	5	7
157	R:R:A327	R:R:L97	3.15	No	No	0	7	7
158	R:R:F333	R:R:L97	4.87	No	No	0	8	7
159	R:R:L146	R:R:N99	4.12	Yes	No	0	8	9
160	R:R:C179	R:R:N99	12.6	No	No	0	7	9
161	R:R:L100	R:R:L146	5.54	No	Yes	0	9	8
162	R:R:L100	R:R:L147	4.15	No	No	0	9	8
163	R:R:L106	R:R:V102	2.98	No	No	0	6	5
164	R:R:A103	R:R:S142	3.42	No	No	0	8	6
165	R:R:D104	R:R:L108	8.14	No	No	0	9	5
166	R:R:C319	R:R:D104	6.22	No	No	0	8	9
167	R:R:L106	R:R:S139	6.01	No	No	0	6	8
168	R:R:L106	R:R:W183	3.42	No	No	0	6	9
169	R:R:F107	R:R:L111	6.09	Yes	Yes	1	6	8
170	R:R:F107	R:R:Y136	4.13	Yes	Yes	1	6	6
171	R:R:F107	R:R:S139	5.28	Yes	No	0	6	8
172	R:R:F107	R:R:F140	7.5	Yes	Yes	1	6	7
173	R:R:F107	R:R:Y312	4.13	Yes	Yes	1	6	5
174	R:R:L111	R:R:T110	2.95	Yes	Yes	1	8	6
175	R:R:T110	R:R:W114	4.85	Yes	Yes	1	6	6
176	R:R:I132	R:R:T110	3.04	Yes	Yes	1	5	6
177	R:R:T110	R:R:Y136	6.24	Yes	Yes	1	6	6
178	R:R:C316	R:R:L111	6.35	No	Yes	1	7	8
179	R:R:F113	R:R:F124	11.79	Yes	Yes	1	6	7
180	R:R:F113	R:R:F128	6.43	Yes	No	1	6	5
181	R:R:F113	R:R:I132	5.02	Yes	Yes	1	6	5
182	R:R:I132	R:R:W114	4.7	Yes	Yes	1	5	6
183	R:R:F133	R:R:W114	8.02	Yes	Yes	1	5	6
184	R:R:W114	R:R:Y136	9.65	Yes	Yes	1	6	6
185	R:R:K120	R:R:Y116	3.58	No	No	0	4	3
186	R:R:F124	R:R:Y116	7.22	Yes	No	0	7	3
187	R:R:R209	R:R:S117	5.27	No	No	0	4	5
188	R:R:K120	R:R:S121	3.06	No	No	0	4	5
189	R:R:F124	R:R:W122	9.02	Yes	Yes	0	7	9
190	R:R:G125	R:R:W122	4.22	No	Yes	0	7	9
191	R:R:L199	R:R:W122	4.56	No	Yes	0	4	9
192	R:R:M208	R:R:W122	10.47	No	Yes	0	5	9
193	R:R:C210	R:R:W122	3.92	No	Yes	0	9	9
194	R:R:F124	R:R:F128	7.5	Yes	No	1	7	5
195	R:R:H127	R:R:V126	4.15	No	No	0	1	2
196	R:R:K130	R:R:V126	4.55	No	No	0	7	2
197	R:R:L199	R:R:V126	4.47	No	No	0	4	2
198	R:R:F128	R:R:I132	3.77	No	Yes	1	5	5
199	R:R:C129	R:R:S197	3.44	No	No	0	9	5
200	R:R:C129	R:R:C210	7.28	No	No	0	9	9
201	R:R:K130	R:R:S197	6.12	No	No	0	7	5
202	R:R:I135	R:R:L131	7.14	No	No	0	4	4
203	R:R:E193	R:R:F133	5.83	Yes	Yes	1	4	5
204	R:R:F133	R:R:L212	10.96	Yes	No	0	5	5
205	R:R:K137	R:R:Y136	13.14	Yes	Yes	1	5	6
206	R:R:Q227	R:R:Y136	3.38	Yes	Yes	1	5	6
207	R:R:Y136	R:R:Y312	11.91	Yes	Yes	1	6	5
208	R:R:F141	R:R:K137	3.72	Yes	Yes	0	7	5
209	R:R:K137	R:R:S190	3.06	Yes	No	0	5	7
210	R:R:E193	R:R:K137	21.6	Yes	Yes	1	4	5
211	R:R:I223	R:R:K137	4.36	No	Yes	1	4	5
212	R:R:K137	R:R:Q227	5.42	Yes	Yes	1	5	5
213	R:R:M138	R:R:T187	7.53	No	No	0	5	3
214	R:R:M138	R:R:S190	4.6	No	No	0	5	7
215	R:R:F140	R:R:F141	3.22	Yes	Yes	0	7	7
216	R:R:F140	R:R:Q227	12.88	Yes	Yes	1	7	5
217	R:R:F140	R:R:Y312	4.13	Yes	Yes	1	7	5
218	R:R:F140	R:R:R318	3.21	Yes	Yes	0	7	9
219	R:R:F141	R:R:L189	7.31	Yes	No	0	7	5
220	R:R:F141	R:R:I230	6.28	Yes	Yes	0	7	4
221	R:R:S142	R:R:W183	13.59	No	No	0	6	9
222	R:R:L145	R:R:M144	8.48	No	Yes	0	5	7
223	R:R:I230	R:R:M144	7.29	Yes	Yes	8	4	7
224	R:R:G231	R:R:M144	6.99	No	Yes	8	5	7
225	R:R:M144	R:R:P235	6.71	Yes	No	0	7	9
226	R:R:I182	R:R:L145	7.14	Yes	No	0	6	5
227	R:R:L145	R:R:L185	4.15	No	No	0	5	4
228	R:R:I182	R:R:L146	4.28	Yes	Yes	0	6	8
229	R:R:L147	R:R:N322	9.61	No	No	2	8	9
230	R:R:L147	R:R:Y326	9.38	No	Yes	2	8	9
231	R:R:C149	R:R:L148	3.17	No	No	0	6	7
232	R:R:A238	R:R:L148	3.15	No	No	0	7	7
233	R:R:C149	R:R:I182	4.91	No	Yes	0	6	6
234	R:R:I150	R:R:R154	6.26	No	No	2	8	9
235	R:R:I150	R:R:Y326	6.04	No	Yes	2	8	9
236	R:R:M239	R:R:S151	7.67	Yes	No	2	7	9
237	R:R:C242	R:R:S151	3.44	No	No	0	7	9
238	R:R:S151	R:R:Y243	8.9	No	Yes	2	9	8
239	R:R:C242	R:R:I152	3.27	No	No	0	7	5
240	R:R:R154	R:R:Y243	8.23	No	Yes	2	9	8
241	R:R:R154	R:R:Y326	7.2	No	Yes	2	9	9
242	R:R:V159	R:R:Y155	8.83	Yes	No	0	7	8
243	R:R:V159	R:R:V245	6.41	Yes	No	0	7	3
244	R:R:I246	R:R:V159	3.07	No	Yes	0	8	7
245	R:R:T249	R:R:V159	7.93	No	Yes	0	5	7
246	R:R:Q160	R:R:S163	5.78	No	No	0	6	4
247	R:R:H165	R:R:R168	7.9	No	No	0	5	7
248	R:R:H167	R:R:R166	12.41	No	No	0	3	4
249	R:R:H167	R:R:R170	18.05	No	No	0	3	5
250	R:R:K176	R:R:L172	7.05	No	No	0	3	2
251	R:R:I182	R:R:S178	3.1	Yes	No	0	6	5
252	R:R:I191	R:R:P192	3.39	No	No	0	4	8
253	R:R:E193	R:R:P192	3.14	Yes	No	0	4	8
254	R:R:E193	R:R:I223	10.93	Yes	No	1	4	4
255	R:R:L195	R:R:Y196	8.21	No	No	0	3	4
256	R:R:T214	R:R:Y196	14.98	No	No	0	5	4
257	R:R:A219	R:R:Y196	5.34	No	No	0	3	4
258	R:R:I213	R:R:Q200	5.49	No	No	0	4	3
259	R:R:Q206	R:R:S202	10.11	No	No	4	5	1
260	R:R:Q206	R:R:R209	16.35	No	No	0	5	4
261	R:R:H216	R:R:T214	4.11	No	No	0	2	5
262	R:R:F220	R:R:T214	7.78	No	No	0	4	5
263	R:R:E218	R:R:H216	4.92	No	No	0	1	2
264	R:R:I221	R:R:V225	3.07	Yes	No	0	2	4
265	R:R:I221	R:R:T287	6.08	Yes	No	0	2	4
266	R:R:F291	R:R:I221	5.02	No	Yes	0	1	2
267	R:R:Q224	R:R:T287	7.09	No	No	0	5	4
268	R:R:N290	R:R:Q224	3.96	No	No	0	3	5
269	R:R:V225	R:R:V229	3.21	No	No	0	4	4
270	R:R:Q227	R:R:Y279	12.4	Yes	Yes	1	5	6
271	R:R:Q227	R:R:Y312	4.51	Yes	Yes	1	5	5
272	R:R:F232	R:R:M228	3.73	Yes	No	9	8	5
273	R:R:M228	R:R:N280	7.01	No	No	9	5	8
274	R:R:G231	R:R:I230	3.53	No	Yes	8	5	4
275	R:R:I230	R:R:V234	3.07	Yes	No	0	4	5
276	R:R:F232	R:R:L233	6.09	Yes	No	0	8	4
277	R:R:F232	R:R:L236	3.65	Yes	No	0	8	6
278	R:R:F232	R:R:Q276	7.03	Yes	No	0	8	8
279	R:R:F232	R:R:L277	3.65	Yes	No	0	8	5
280	R:R:F232	R:R:N280	16.92	Yes	No	9	8	8
281	R:R:P235	R:R:V234	3.53	No	No	0	9	5
282	R:R:L236	R:R:S240	3	No	No	0	6	4
283	R:R:F272	R:R:L236	7.31	No	No	0	9	6
284	R:R:M239	R:R:Y243	5.99	Yes	Yes	2	7	8
285	R:R:F272	R:R:M239	8.71	No	Yes	0	9	7
286	R:R:M239	R:R:Y326	3.59	Yes	Yes	2	7	9
287	R:R:C242	R:R:F241	4.19	No	No	0	7	3
288	R:R:F241	R:R:V245	5.24	No	No	0	3	3
289	R:R:I265	R:R:Y243	10.88	No	Yes	0	7	8
290	R:R:V268	R:R:Y243	5.05	No	Yes	0	8	8
291	R:R:V269	R:R:Y243	3.79	No	Yes	0	7	8
292	R:R:Y243	R:R:Y326	5.96	Yes	Yes	2	8	9
293	R:R:R248	R:R:V245	3.92	No	No	0	4	3
294	R:R:I247	R:R:I262	5.89	No	No	0	4	5
295	R:R:A261	R:R:L250	4.73	No	No	0	7	8
296	R:R:A253	R:R:N255	3.13	No	No	0	3	4
297	R:R:E257	R:R:F256	3.5	No	No	0	5	3
298	R:R:N259	R:R:R258	3.62	No	No	0	5	6
299	R:R:I329	R:R:V264	6.14	No	No	0	6	7
300	R:R:L325	R:R:V268	7.45	Yes	No	0	7	8
301	R:R:I273	R:R:V269	3.07	No	No	0	5	7
302	R:R:L325	R:R:V271	4.47	Yes	No	0	7	6
303	R:R:F275	R:R:V274	5.24	No	No	0	7	5
304	R:R:F275	R:R:V317	5.24	No	No	0	7	5
305	R:R:F275	R:R:R318	3.21	No	Yes	0	7	9
306	R:R:Q276	R:R:R318	18.69	No	Yes	0	8	9
307	R:R:P278	R:R:T311	3.5	No	No	0	9	6
308	R:R:V283	R:R:Y279	8.83	No	Yes	0	5	6
309	R:R:Y279	R:R:Y308	13.9	Yes	Yes	1	6	4
310	R:R:T311	R:R:Y279	8.74	No	Yes	0	6	6
311	R:R:Y279	R:R:Y312	27.8	Yes	Yes	1	6	5
312	R:R:Q286	R:R:V282	5.73	No	Yes	1	5	5
313	R:R:A307	R:R:V282	3.39	No	Yes	0	5	5
314	R:R:V282	R:R:Y308	3.79	Yes	Yes	1	5	4
315	R:R:T311	R:R:V282	7.93	No	Yes	0	6	5
316	R:R:A285	R:R:L304	3.15	No	No	0	5	6
317	R:R:Q286	R:R:Y308	13.53	No	Yes	1	5	4
318	R:R:N292	R:R:T294	11.7	No	No	0	2	3
319	R:R:S295	R:R:T294	4.8	No	No	0	1	3
320	R:R:L300	R:R:T297	2.95	No	No	0	3	5
321	R:R:E299	R:R:K302	14.85	No	No	0	5	3
322	R:R:Y308	R:R:Y312	3.97	Yes	Yes	1	4	5
323	R:R:C319	R:R:R318	5.57	No	Yes	0	8	9
324	R:R:N322	R:R:R318	8.44	No	Yes	0	9	9
325	R:R:L325	R:R:V321	2.98	Yes	No	0	7	6
326	R:R:N322	R:R:Y326	5.81	No	Yes	2	9	9
327	R:R:F324	R:R:F328	13.93	No	No	0	6	7
328	R:R:F328	R:R:L337	6.09	No	No	0	7	6
329	R:R:N335	R:R:V331	4.43	No	No	0	5	5
330	R:R:D336	R:R:F333	3.58	No	No	0	5	8
331	R:R:F338	R:R:R334	3.21	No	No	0	4	8
332	R:R:I247	R:R:I265	2.94	No	No	0	4	7
333	R:R:N36	R:R:T37	2.92	No	No	0	6	5
334	L:L:P41	R:R:F44	2.89	Yes	No	0	7	2
335	R:R:F113	R:R:P112	2.89	Yes	No	0	6	9
336	L:L:P96	L:L:R46	2.88	No	No	0	4	3
337	R:R:K339	R:R:K342	2.87	No	No	0	4	5
338	R:R:I191	R:R:L195	2.85	No	No	0	4	3
339	R:R:I247	R:R:L251	2.85	No	No	0	4	5
340	R:R:I293	R:R:N292	2.83	No	No	0	3	2
341	R:R:D52	R:R:K302	2.77	No	No	0	3	3
342	R:R:D198	R:R:K130	2.77	No	No	0	4	7
343	R:R:A226	R:R:F141	2.77	No	Yes	0	3	7
344	R:R:L300	R:R:L304	2.77	No	No	0	3	6
345	R:R:D343	R:R:L344	2.71	No	No	0	4	4
346	R:R:A315	R:R:Y279	2.67	No	Yes	1	8	6
347	R:R:A315	R:R:Y312	2.67	No	Yes	1	8	5
348	L:L:L63	L:L:Q51	2.66	Yes	No	0	8	9
349	R:R:R201	R:R:S203	2.64	No	No	0	1	2
350	R:R:F324	R:R:V71	2.62	No	Yes	0	6	5
351	R:R:R334	R:R:V331	2.62	No	No	0	8	5
352	R:R:Q224	R:R:Q286	2.56	No	No	0	5	5
353	R:R:V156	R:R:Y155	2.52	No	No	0	6	8
354	L:L:L63	L:L:R49	2.43	Yes	No	0	8	5
355	L:L:L65	L:L:R69	2.43	No	No	0	4	5
356	R:R:L250	R:R:R258	2.43	No	No	0	8	6
357	L:L:G26	L:L:G27	2.11	No	No	0	6	5
358	R:R:A103	R:R:G143	1.95	No	No	0	8	9
359	R:R:A115	R:R:P62	1.87	No	No	0	7	6
360	L:L:P41	R:R:V39	1.77	Yes	No	0	7	5
361	R:R:G181	R:R:I184	1.76	No	No	0	2	4
362	R:R:G330	R:R:I329	1.76	No	No	0	8	6
363	R:R:G75	R:R:L74	1.71	No	No	0	7	4
364	R:R:G75	R:R:L78	1.71	No	No	0	7	6
365	R:R:A207	R:R:S121	1.71	No	No	0	1	5
366	R:R:A186	R:R:S142	1.71	No	No	0	7	6
367	R:R:G281	R:R:L284	1.71	No	No	0	6	5
368	R:R:A101	R:R:V80	1.7	No	No	0	9	7
369	R:R:A164	R:R:V156	1.7	No	No	0	5	6
370	R:R:L61	R:R:P62	1.64	Yes	No	0	6	6
371	R:R:L314	R:R:P278	1.64	No	No	0	7	9
372	R:R:S121	R:R:V123	1.62	No	No	0	5	2
373	L:L:A42	L:L:K43	1.61	No	No	0	2	4
374	R:R:A118	R:R:K57	1.61	No	Yes	0	5	4
375	R:R:A134	R:R:M138	1.61	No	No	0	5	5
376	L:L:V44	L:L:V45	1.6	No	No	0	4	8
377	R:R:V264	R:R:V268	1.6	No	No	0	7	8
378	R:R:V270	R:R:V274	1.6	No	No	0	4	5
379	L:L:C31	L:L:L33	1.59	No	No	0	9	8
380	R:R:A134	R:R:L194	1.58	No	No	0	5	4
381	R:R:A267	R:R:L325	1.58	No	Yes	0	5	7
382	L:L:E52	L:L:P53	1.57	No	No	0	5	5
383	R:R:A289	R:R:N290	1.56	No	No	0	3	3
384	R:R:I135	R:R:S139	1.55	No	No	0	4	8
385	R:R:I67	R:R:V71	1.54	No	Yes	0	5	5
386	R:R:A157	R:R:D153	1.54	No	No	0	8	8
387	R:R:I266	R:R:V270	1.54	No	No	0	4	4
388	R:R:I221	R:R:T222	1.52	Yes	No	0	2	1
389	R:R:K263	R:R:V264	1.52	No	No	0	5	7
390	R:R:L300	R:R:S301	1.5	No	No	0	3	3
391	R:R:G330	R:R:R334	1.5	No	No	0	8	8
392	R:R:L43	R:R:V39	1.49	No	No	0	4	5
393	R:R:I158	R:R:I246	1.47	No	No	0	8	8
394	R:R:K260	R:R:K263	1.44	No	No	0	7	5
395	R:R:I105	R:R:L109	1.43	No	No	0	7	4
396	R:R:Q252	R:R:T249	1.42	No	No	0	5	5
397	R:R:K51	R:R:N55	1.4	No	No	0	3	5
398	R:R:H167	R:R:V171	1.38	No	No	0	3	6
399	L:L:E52	L:L:K50	1.35	No	No	0	5	4
400	L:L:L86	L:L:Q85	1.33	No	No	0	5	4
401	L:L:R67	L:L:V45	1.31	No	No	0	5	8
402	R:R:F70	R:R:V71	1.31	No	Yes	0	5	5
403	R:R:E299	R:R:Q303	1.27	No	No	0	5	3
404	L:L:K43	L:L:R67	1.24	No	No	0	4	5
405	L:L:H89	L:L:Q85	1.24	No	No	0	4	4
406	R:R:F341	R:R:L337	1.22	No	No	0	5	6
407	L:L:L81	L:L:W82	1.14	No	Yes	0	1	8
408	R:R:Q160	R:R:Y155	1.13	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:D25	7.2075	4	1	6
2	L:L:Q29	7.335	4	4	5
3	L:L:P41	3.3375	4	0	7
4	L:L:Y48	8.2225	4	3	9
5	L:L:C57	4.9675	4	4	9
6	L:L:L63	5.414	5	6	8
7	L:L:Q71	10.5125	4	0	5
8	L:L:D77	12.925	4	0	8
9	L:L:W82	10.146	5	3	8
10	L:L:V83	5.79	4	3	9
11	R:R:Y41	7.5325	4	0	8
12	R:R:L47	7.9475	4	6	4
13	R:R:F56	9.64	4	1	4
14	R:R:K57	6.07	5	1	4
15	R:R:F60	7.94	4	1	5
16	R:R:L61	4.41	4	1	6
17	R:R:Y65	5.538	5	1	7
18	R:R:V71	2.2225	4	0	5
19	R:R:Y85	8.7675	4	5	4
20	R:R:F86	7.305	4	5	5
21	R:R:R88	10.6525	4	5	6
22	R:R:M92	8.02	4	2	6
23	R:R:Y96	6.34167	6	2	7
24	R:R:F107	5.426	5	1	6
25	R:R:T110	4.27	4	1	6
26	R:R:L111	6.1925	4	1	8
27	R:R:F113	6.5325	4	1	6
28	R:R:W114	6.338	5	1	6
29	R:R:W122	6.438	5	0	9
30	R:R:F124	8.8825	4	1	7
31	R:R:I132	4.1325	4	1	5
32	R:R:F133	7.695	4	1	5
33	R:R:Y136	9.05571	7	1	6
34	R:R:K137	8.55	6	1	5
35	R:R:F140	6.188	5	1	7
36	R:R:F141	4.66	5	0	7
37	R:R:M144	7.3675	4	8	7
38	R:R:L146	4.365	4	0	8
39	R:R:V159	6.56	4	0	7
40	R:R:I182	4.8575	4	0	6
41	R:R:E193	10.375	4	1	4
42	R:R:I221	3.9225	4	0	2
43	R:R:Q227	7.718	5	1	5
44	R:R:I230	5.0425	4	8	4
45	R:R:F232	6.845	6	9	8
46	R:R:M239	6.49	4	2	7
47	R:R:Y243	6.97143	7	2	8
48	R:R:Y279	12.39	6	1	6
49	R:R:V282	5.21	4	1	5
50	R:R:Y308	7.71167	6	1	4
51	R:R:Y312	7.7625	8	1	5
52	R:R:R318	7.824	5	0	9
53	R:R:L325	4.12	4	0	7
54	R:R:Y326	6.33	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S24	R:R:N305	24.0466	2.98	No	No	0	5	4
2	L:L:S24	R:R:Y308	25.268	7.63	No	Yes	0	5	4
3	L:L:D25	R:R:Y308	12.4448	3.45	Yes	Yes	1	6	4
4	R:R:Y308	R:R:Y312	34.457	3.97	Yes	Yes	1	4	5
5	R:R:Y136	R:R:Y312	19.7763	11.91	Yes	Yes	1	6	5
6	R:R:K50	R:R:N305	23.6559	5.6	No	No	0	3	4
7	L:L:C31	R:R:K50	24.2645	3.23	No	No	0	9	3
8	L:L:C31	L:L:C57	20.193	7.28	No	Yes	0	9	9
9	L:L:L63	R:R:L47	10.3186	12.46	Yes	Yes	6	8	4
10	L:L:L63	L:L:Q51	13.9199	2.66	Yes	No	0	8	9
11	L:L:C57	L:L:Q51	14.4189	3.05	Yes	No	0	9	9
12	R:R:Q286	R:R:Y308	30.805	13.53	No	Yes	1	5	4
13	R:R:Q224	R:R:Q286	30.8571	2.56	No	No	0	5	5
14	R:R:N290	R:R:Q224	28.0262	3.96	No	No	0	3	5
15	L:L:S58	R:R:N290	27.1927	7.45	No	No	0	5	3
16	L:L:I59	L:L:S58	26.7719	3.1	No	No	0	5	5
17	L:L:I59	L:L:Y35	22.8566	6.04	No	No	0	5	7
18	L:L:D77	L:L:Y35	22.4138	24.14	Yes	No	0	8	7
19	L:L:D77	L:L:E80	16.9454	15.59	Yes	No	0	8	4
20	L:L:E80	L:L:W82	14.9289	15.27	No	Yes	3	4	8
21	L:L:I40	L:L:W82	13.5991	7.05	No	Yes	0	7	8
22	L:L:I40	L:L:P41	11.27	3.39	No	Yes	0	7	7
23	R:R:F140	R:R:Y312	50.3414	4.13	Yes	Yes	1	7	5
24	R:R:F140	R:R:R318	100	3.21	Yes	Yes	0	7	9
25	R:R:C319	R:R:R318	11.832	5.57	No	Yes	0	8	9
26	R:R:C319	R:R:D104	10.9382	6.22	No	No	0	8	9
27	R:R:N322	R:R:R318	83.9813	8.44	No	Yes	0	9	9
28	R:R:N322	R:R:Y326	79.855	5.81	No	Yes	2	9	9
29	R:R:I150	R:R:Y326	42.4917	6.04	No	Yes	2	8	9
30	R:R:I150	R:R:Y96	45.2938	4.84	No	Yes	2	8	7
31	R:R:S175	R:R:Y96	37.6388	3.82	No	Yes	2	8	7
32	R:R:S175	R:R:T95	37.0713	4.8	No	No	0	8	5
33	R:R:L89	R:R:T95	36.0568	2.95	No	No	0	7	5
34	R:R:L89	R:R:Y83	32.997	4.69	No	No	0	7	7
35	R:R:D94	R:R:Y83	30.9434	9.2	No	No	0	8	7
36	R:R:D94	R:R:R88	25.6381	9.53	No	Yes	0	8	6
37	R:R:F86	R:R:R88	22.4906	6.41	Yes	Yes	5	5	6
38	R:R:F86	R:R:Y85	19.4102	8.25	Yes	Yes	5	5	4
39	R:R:L340	R:R:Y85	16.2929	8.21	No	Yes	0	5	4
40	R:R:L340	R:R:T82	14.1543	5.9	No	No	0	5	6
41	R:R:L337	R:R:T82	13.0809	7.37	No	No	0	6	6
42	R:R:F141	R:R:I230	10.7915	6.28	Yes	Yes	0	7	4
43	R:R:I182	R:R:L145	10.4269	7.14	Yes	No	0	6	5
44	R:R:T110	R:R:Y136	25.2886	6.24	Yes	Yes	1	6	6
45	R:R:I132	R:R:W114	31.8277	4.7	Yes	Yes	1	5	6
46	R:R:F113	R:R:I132	32.7393	5.02	Yes	Yes	1	6	5
47	R:R:F113	R:R:F124	29.3395	11.79	Yes	Yes	1	6	7
48	R:R:F128	R:R:I132	31.0161	3.77	No	Yes	1	5	5
49	R:R:F124	R:R:F128	29.3162	7.5	Yes	No	1	7	5
50	R:R:F124	R:R:Y116	17.3334	7.22	Yes	No	0	7	3
51	R:R:K120	R:R:Y116	13.8719	3.58	No	No	0	4	3
52	R:R:K120	R:R:S121	10.4077	3.06	No	No	0	4	5
53	R:R:F124	R:R:W122	38.0446	9.02	Yes	Yes	0	7	9
54	R:R:L199	R:R:W122	17.3183	4.56	No	Yes	0	4	9
55	R:R:C210	R:R:W122	10.3926	3.92	No	Yes	0	9	9
56	R:R:L199	R:R:V126	13.8596	4.47	No	No	0	4	2
57	R:R:M239	R:R:Y326	16.164	3.59	Yes	Yes	2	7	9
58	R:R:M239	R:R:S151	14.1022	7.67	Yes	No	2	7	9
59	R:R:Y243	R:R:Y326	32.0662	5.96	Yes	Yes	2	8	9
60	R:R:S151	R:R:Y243	15.8789	8.9	No	Yes	2	9	8
61	R:R:C242	R:R:S151	28.129	3.44	No	No	0	7	9
62	R:R:C242	R:R:F241	24.4139	4.19	No	No	0	7	3
63	R:R:F241	R:R:V245	22.5523	5.24	No	No	0	3	3
64	R:R:V159	R:R:V245	18.8208	6.41	Yes	No	0	7	3
65	R:R:V268	R:R:Y243	14.0775	5.05	No	Yes	0	8	8
66	R:R:F107	R:R:Y136	18.2971	4.13	Yes	Yes	1	6	6
67	R:R:F107	R:R:F140	26.8527	7.5	Yes	Yes	1	6	7
68	R:R:Q227	R:R:Y136	17.2964	3.38	Yes	Yes	1	5	6
69	R:R:F140	R:R:Q227	21.8504	12.88	Yes	Yes	1	7	5
70	R:R:F141	R:R:K137	10.6435	3.72	Yes	Yes	0	7	5
71	R:R:W114	R:R:Y136	27.2859	9.65	Yes	Yes	1	6	6
72	R:R:I132	R:R:T110	33.5988	3.04	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S24	R:R:N305	2.98	0	No	No	5	4	0	1
L:L:S24	R:R:Y308	7.63	0	No	Yes	5	4	0	1
L:L:D25	R:R:W114	4.47	1	Yes	Yes	6	6	0	1
L:L:D25	R:R:F133	5.97	1	Yes	Yes	6	5	0	1
L:L:D25	R:R:Y136	14.94	1	Yes	Yes	6	6	0	1
L:L:D25	R:R:Y308	3.45	1	Yes	Yes	6	4	0	1
L:L:A28	R:R:K57	4.82	0	No	Yes	7	4	0	1
L:L:Q29	R:R:S202	7.22	4	Yes	No	5	1	0	1
L:L:Q29	R:R:Q206	10.24	4	Yes	No	5	5	0	1
L:L:D30	R:R:L47	10.86	0	No	Yes	7	4	0	1
L:L:C31	R:R:K50	3.23	0	No	No	9	3	0	1
L:L:L33	R:R:C48	7.94	0	No	No	8	6	0	1
L:L:L33	R:R:S301	9.01	0	No	No	8	3	0	1
L:L:K34	R:R:E45	6.75	0	No	No	5	2	0	1
L:L:K34	R:R:S296	7.65	0	No	No	5	1	0	1
L:L:S36	R:R:F44	3.96	0	No	No	6	2	0	1
L:L:S36	R:R:E45	4.31	0	No	No	6	2	0	1
L:L:R38	R:R:F44	10.69	0	No	No	5	2	0	1
L:L:R49	R:R:S203	9.22	0	No	No	5	2	0	1
L:L:E52	R:R:Q200	8.92	0	No	No	5	3	0	1
L:L:P53	R:R:E215	3.14	0	No	No	5	6	0	1
L:L:S54	R:R:S211	4.89	4	No	No	6	4	0	1
L:L:L55	R:R:L212	5.54	0	No	No	7	5	0	1
L:L:S58	R:R:N290	7.45	0	No	No	5	3	0	1
L:L:P60	R:R:V217	3.53	0	No	No	5	2	0	1
L:L:L63	R:R:L47	12.46	6	Yes	Yes	8	4	0	1
L:L:K68	R:R:D30	5.53	0	No	No	5	4	0	1
L:L:K68	R:R:I33	13.09	0	No	No	5	5	0	1
L:L:Q71	R:R:Y41	19.16	0	Yes	Yes	5	8	0	1
L:L:A72	R:R:Y41	4	0	No	Yes	3	8	0	1
L:L:E73	R:R:L47	5.3	0	No	Yes	6	4	0	1
L:L:L74	R:R:Y41	3.52	0	No	Yes	6	8	0	1
L:L:L74	R:R:S46	3	0	No	No	6	4	0	1
L:L:C75	R:R:L47	3.17	6	No	Yes	9	4	0	1
R:R:G34	R:R:I33	3.53	7	No	No	5	5	2	1
R:R:I33	R:R:T38	9.12	7	No	No	5	5	1	2
R:R:G34	R:R:T38	3.64	7	No	No	5	5	2	2
R:R:D40	R:R:Y41	3.45	0	No	Yes	6	8	2	1
R:R:C298	R:R:C48	7.28	0	No	No	5	6	2	1
R:R:K50	R:R:V53	3.04	0	No	No	3	4	1	2
R:R:K50	R:R:N305	5.6	0	No	No	3	4	1	1
R:R:K57	R:R:V53	3.04	1	Yes	No	4	4	1	2
R:R:K57	R:R:L61	7.05	1	Yes	Yes	4	6	1	2
R:R:D309	R:R:K57	13.83	1	No	Yes	5	4	2	1
R:R:D309	R:R:L61	5.43	1	No	Yes	5	6	2	2
R:R:F107	R:R:Y136	4.13	1	Yes	Yes	6	6	2	1
R:R:F107	R:R:Y312	4.13	1	Yes	Yes	6	5	2	2
R:R:T110	R:R:W114	4.85	1	Yes	Yes	6	6	2	1
R:R:I132	R:R:T110	3.04	1	Yes	Yes	5	6	2	2
R:R:T110	R:R:Y136	6.24	1	Yes	Yes	6	6	2	1
R:R:I132	R:R:W114	4.7	1	Yes	Yes	5	6	2	1
R:R:F133	R:R:W114	8.02	1	Yes	Yes	5	6	1	1
R:R:W114	R:R:Y136	9.65	1	Yes	Yes	6	6	1	1
R:R:E193	R:R:F133	5.83	1	Yes	Yes	4	5	2	1
R:R:F133	R:R:L212	10.96	1	Yes	No	5	5	1	1
R:R:K137	R:R:Y136	13.14	1	Yes	Yes	5	6	2	1
R:R:Q227	R:R:Y136	3.38	1	Yes	Yes	5	6	2	1
R:R:Y136	R:R:Y312	11.91	1	Yes	Yes	6	5	1	2
R:R:E193	R:R:K137	21.6	1	Yes	Yes	4	5	2	2
R:R:K137	R:R:Q227	5.42	1	Yes	Yes	5	5	2	2
R:R:I213	R:R:Q200	5.49	0	No	No	4	3	2	1
R:R:Q206	R:R:S202	10.11	4	No	No	5	1	1	1
R:R:Q206	R:R:R209	16.35	4	No	No	5	4	1	2
R:R:N290	R:R:Q224	3.96	0	No	No	3	5	1	2
R:R:Q227	R:R:Y279	12.4	1	Yes	Yes	5	6	2	2
R:R:Q227	R:R:Y312	4.51	1	Yes	Yes	5	5	2	2
R:R:Y279	R:R:Y308	13.9	1	Yes	Yes	6	4	2	1
R:R:Y279	R:R:Y312	27.8	1	Yes	Yes	6	5	2	2
R:R:Q286	R:R:V282	5.73	1	No	Yes	5	5	2	2
R:R:V282	R:R:Y308	3.79	1	Yes	Yes	5	4	2	1
R:R:Q286	R:R:Y308	13.53	1	No	Yes	5	4	2	1
R:R:Y308	R:R:Y312	3.97	1	Yes	Yes	4	5	1	2
L:L:P41	R:R:F44	2.89	0	Yes	No	7	2	0	1
R:R:R201	R:R:S203	2.64	0	No	No	1	2	2	1
R:R:Q224	R:R:Q286	2.56	0	No	No	5	5	2	2
L:L:P41	R:R:V39	1.77	0	Yes	No	7	5	0	1
R:R:A118	R:R:K57	1.61	0	No	Yes	5	4	2	1
R:R:A289	R:R:N290	1.56	0	No	No	3	3	2	1
R:R:L300	R:R:S301	1.5	0	No	No	3	3	2	1
R:R:L43	R:R:V39	1.49	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KO4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	362
Number of Links	408
Number of Hubs	54
Number of Links mediated by Hubs	195
Number of Communities	9
Number of Nodes involved in Communities	72
Number of Links involved in Communities	105

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	128864
Length Of Smallest Path	3
Average Path Length	15.8167
Length of Longest Path	42
Minimum Path Strength	1.275
Average Path Strength	6.20611
Maximum Path Strength	19.865
Minimum Path Correlation	0.7
Average Path Correlation	0.959548
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	62.6085
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.6991
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • chemokine (C-C motif) ligand 21 binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-C motif chemokine 19 receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine (C-C motif) ligand 19 binding • C-C motif chemokine 21 receptor activity • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • dendritic cell differentiation • mature conventional dendritic cell differentiation • leukocyte differentiation • cell surface receptor signaling pathway • CCL19-activated CCR7 signaling pathway • response to cytokine • response to chemokine • chemokine (C-C motif) ligand 19 signaling pathway • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • C-C chemokine receptor CCR7 signaling pathway • thymic T cell selection • cell activation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • T cell differentiation in thymus • T cell activation • immune system process • negative thymic T cell selection • T cell differentiation • negative T cell selection • T cell selection • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • positive regulation of biological process • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component organization • pseudopodium assembly • cellular component assembly • positive regulation of cell projection organization • cellular component organization or biogenesis • positive regulation of cellular process • plasma membrane bounded cell projection organization • positive regulation of cellular component biogenesis • regulation of cell projection organization • regulation of cell projection assembly • regulation of cellular component biogenesis • regulation of plasma membrane bounded cell projection assembly • positive regulation of pseudopodium assembly • regulation of pseudopodium assembly • cell projection assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • pseudopodium organization • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • positive regulation of cell-matrix adhesion • cell adhesion • cell-matrix adhesion • positive regulation of cell-substrate adhesion • regulation of cell-matrix adhesion • cell chemotaxis • chemotaxis • dendritic cell chemotaxis • response to external stimulus • leukocyte migration • dendritic cell migration • myeloid dendritic cell chemotaxis • taxis • mononuclear cell migration • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • regulation of biosynthetic process • regulation of type II interferon production • type II interferon production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • cytokine production • regulation of cytokine production • metabolic process • regulation of macromolecule biosynthetic process • regulation of multicellular organismal process • macromolecule metabolic process • regulation of metabolic process • regulation of humoral immune response • humoral immune response • immune response • positive regulation of response to stimulus • positive regulation of humoral immune response • regulation of response to stimulus • positive regulation of immune response • regulation of immune response • regulation of immune system process • positive regulation of immune system process • positive regulation of cell communication • immune response-regulating cell surface receptor signaling pathway • positive regulation of signal transduction • positive regulation of T cell receptor signaling pathway • regulation of antigen receptor-mediated signaling pathway • regulation of signal transduction • immune response-activating signaling pathway • immune response-regulating signaling pathway • regulation of signaling • immune response-activating cell surface receptor signaling pathway • regulation of T cell receptor signaling pathway • T cell receptor signaling pathway • regulation of cell communication • antigen receptor-mediated signaling pathway • activation of immune response • positive regulation of antigen receptor-mediated signaling pathway • positive regulation of signaling • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • CCL21-activated CCR7 signaling pathway • chemokine (C-C motif) ligand 21 signaling pathway • regulation of localization • import into cell • transport • vesicle-mediated transport • localization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of transport • endocytosis • receptor-mediated endocytosis • lymphocyte migration into lymphoid organs • lymphocyte migration • lymphocyte migration into lymph node • ruffle organization • phospholipase C/protein kinase C signal transduction • positive regulation of phospholipase C/protein kinase C signal transduction • positive regulation of locomotion • regulation of cell motility • regulation of locomotion • positive regulation of cell motility • regulation of leukocyte activation • regulation of cell activation • positive regulation of leukocyte cell-cell adhesion • positive regulation of T cell costimulation • leukocyte cell-cell adhesion • positive regulation of cell-cell adhesion • positive regulation of lymphocyte activation • positive regulation of cell activation • cell-cell adhesion • positive regulation of leukocyte activation • regulation of cell-cell adhesion • positive regulation of T cell activation • regulation of T cell costimulation • regulation of T cell activation • lymphocyte costimulation • regulation of leukocyte cell-cell adhesion • positive regulation of multicellular organismal process • T cell costimulation • regulation of lymphocyte activation • regulation of interleukin-1 production • interleukin-1 production • regulation of interleukin-1 beta production • interleukin-1 beta production • response to nitric oxide • regulation of small GTPase mediated signal transduction • Rac protein signal transduction • regulation of Rac protein signal transduction • positive regulation of Rac protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of dendritic cell chemotaxis • regulation of response to external stimulus • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of response to external stimulus • regulation of cell migration • positive regulation of mononuclear cell migration • regulation of mononuclear cell migration • regulation of dendritic cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • regulation of Cdc42 protein signal transduction • regulation of Rho protein signal transduction • Rho protein signal transduction • Cdc42 protein signal transduction • positive regulation of acute inflammatory response to antigenic stimulus • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • positive regulation of acute inflammatory response • inflammatory response to antigenic stimulus • positive regulation of hypersensitivity • positive regulation of inflammatory response • response to stress • regulation of response to stress • acute inflammatory response • hypersensitivity • regulation of hypersensitivity • defense response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • positive regulation of inflammatory response to antigenic stimulus • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • regulation of interleukin-12 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • interleukin-12 production • positive regulation of interleukin-12 production • positive regulation of gene expression • positive regulation of cytokine production • positive regulation of neutrophil chemotaxis • neutrophil migration • granulocyte migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • regulation of granulocyte chemotaxis • positive regulation of neutrophil migration • granulocyte chemotaxis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • regulation of dendritic cell dendrite assembly • dendritic cell dendrite assembly • regulation of leukocyte apoptotic process • dendritic cell apoptotic process • negative regulation of dendritic cell apoptotic process • negative regulation of programmed cell death • leukocyte apoptotic process • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of cellular process • regulation of dendritic cell apoptotic process • apoptotic process • programmed cell death • positive regulation of immunological synapse formation • immunological synapse formation • cell-cell recognition • regulation of immunological synapse formation • cell recognition • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of cellular component size • regulation of protein-containing complex assembly • positive regulation of protein-containing complex assembly • positive regulation of protein polymerization • protein-containing complex assembly • actin filament-based process • regulation of actin filament polymerization • protein polymerization • actin polymerization or depolymerization • regulation of actin filament organization • actin cytoskeleton organization • actin filament polymerization • protein-containing complex organization • positive regulation of cytoskeleton organization • regulation of actin polymerization or depolymerization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of organelle organization • organelle organization • regulation of protein polymerization • regulation of actin filament length • regulation of actin cytoskeleton organization • regulation of supramolecular fiber organization • supramolecular fiber organization • positive regulation of actin filament polymerization • cytoskeleton organization • regulation of anatomical structure size • calcium ion transmembrane import into cytosol • monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • transmembrane transport • release of sequestered calcium ion into cytosol • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • filopodium assembly • regulation of filopodium assembly • positive regulation of filopodium assembly • establishment of lymphocyte polarity • establishment of T cell polarity • establishment or maintenance of cell polarity • establishment of cell polarity • negative regulation of interleukin-12 production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • regulation of dendritic cell antigen processing and presentation • positive regulation of dendritic cell antigen processing and presentation • positive regulation of antigen processing and presentation • antigen processing and presentation • regulation of antigen processing and presentation • dendritic cell antigen processing and presentation • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • cell surface • external side of plasma membrane • mitochondrion • CCR chemokine receptor binding • signaling receptor binding • CCR7 chemokine receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • molecular function activator activity • signaling receptor activator activity • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • mesangial cell-matrix adhesion • regulation of lymphocyte migration • positive regulation of lymphocyte migration • positive regulation of T cell migration • regulation of T cell migration • T cell migration • eosinophil chemotaxis • eosinophil migration • positive regulation of glycoprotein metabolic process • positive regulation of protein metabolic process • carbohydrate derivative metabolic process • regulation of primary metabolic process • protein metabolic process • regulation of glycoprotein biosynthetic process • positive regulation of glycoprotein biosynthetic process • carbohydrate derivative biosynthetic process • regulation of protein metabolic process • glycoprotein biosynthetic process • primary metabolic process • glycoprotein metabolic process • regulation of glycoprotein metabolic process • negative regulation of locomotion • regulation of leukocyte adhesion to vascular endothelial cell • negative regulation of cell adhesion • leukocyte tethering or rolling • negative regulation of leukocyte tethering or rolling • negative regulation of cellular extravasation • cellular extravasation • negative regulation of cell migration • negative regulation of leukocyte adhesion to vascular endothelial cell • regulation of leukocyte tethering or rolling • negative regulation of leukocyte migration • negative regulation of leukocyte cell-cell adhesion • negative regulation of immune system process • leukocyte adhesion to vascular endothelial cell • negative regulation of cell-cell adhesion • negative regulation of cell motility • regulation of cellular extravasation • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell adhesion mediated by integrin • regulation of cell adhesion mediated by integrin • cell adhesion mediated by integrin • negative regulation of dendritic cell dendrite assembly • negative regulation of plasma membrane bounded cell projection assembly • negative regulation of cell projection organization • negative regulation of cellular component organization • regulation of myeloid dendritic cell chemotaxis • positive regulation of myeloid dendritic cell chemotaxis • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • positive regulation of T cell chemotaxis • regulation of lymphocyte chemotaxis • regulation of T cell chemotaxis • lymphocyte chemotaxis • positive regulation of lymphocyte chemotaxis • T cell chemotaxis
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	CCL21
UniProt	O00585
Sequence	>9KO4_nogp_Chain_L S D G G A Q D C C L K Y S Q R K I P A K V V R S Y R K Q E P S L G C S I P A I L F L P R K R S Q A E L C A D P K E L W V Q Q L M Q H L D K T P S P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P32248
Sequence	>9KO4_nogp_Chain_R D D Y I G D N T T V D Y T L F E S L C S K K D V R N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F K R L K T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K S W V F G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q A V S A H R H R A R V L L I S K L S C V G I W I L A T V L S I P E L L Y S D L Q R S S S E Q A M R C S L I T E H V E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A R N F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F N I T S S T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K F R N D L F K L F K D L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6QZH	A	Protein	Chemokine	CCR7	Homo sapiens	-	PubChem 136165388; Na	-	2.1	2019-09-04	doi.org/10.1016/j.cell.2019.07.028
	9KO2	A	Protein	Chemokine	CCR7	Homo sapiens	CCL19	-	Gi1/β1	2.98	2025-11-26	To be published
	9KO2 (No Gprot)	A	Protein	Chemokine	CCR7	Homo sapiens	CCL19	-		2.98	2025-11-26	To be published
	9KO4	A	Protein	Chemokine	CCR7	Homo sapiens	CCL21	-	Gi1/β1/γ2	3.3	2025-11-26	To be published
	9KO4 (No Gprot)	A	Protein	Chemokine	CCR7	Homo sapiens	CCL21	-		3.3	2025-11-26	To be published
	9KO6	A	Protein	Chemokine	CCR7	Homo sapiens	CCL19	-	-	3.3	2025-11-26	To be published
	9L16	A	Protein	Chemokine	CCR7	Homo sapiens	CCL21	-	-	3.5	2025-12-17	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KO4_nogp.zip

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