psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P39	4.91	Yes	No	1	0	8
2	L:L:?1	R:R:S42	5.61	Yes	No	1	0	9
3	L:L:?1	R:R:M43	3.17	Yes	Yes	0	0	8
4	L:L:?1	R:R:H88	7.69	Yes	Yes	1	0	9
5	L:L:?1	R:R:G92	5.12	Yes	No	1	0	9
6	L:L:?1	R:R:V95	11.14	Yes	No	1	0	9
7	L:L:?1	R:R:Y99	5.26	Yes	Yes	1	0	9
8	L:L:?1	R:R:M117	14.8	Yes	No	0	0	9
9	L:L:?1	R:R:G121	3.84	Yes	No	0	0	7
10	L:L:?1	R:R:T186	4.41	Yes	No	1	0	9
11	L:L:?1	R:R:W187	5.11	Yes	Yes	1	0	9
12	L:L:?1	R:R:F334	5.46	Yes	Yes	1	0	8
13	L:L:?1	R:R:V337	6.68	Yes	No	1	0	8
14	L:L:?1	R:R:R338	9.08	Yes	No	1	0	9
15	L:L:?1	R:R:S341	11.23	Yes	No	1	0	8
16	L:L:?1	R:R:Q344	8.96	Yes	Yes	1	0	9
17	R:R:P36	R:R:Y99	4.17	No	Yes	0	6	9
18	R:R:L38	R:R:R338	10.93	No	No	0	6	9
19	R:R:P39	R:R:V95	3.53	No	No	1	8	9
20	R:R:P39	R:R:Y99	8.34	No	Yes	1	8	9
21	R:R:F41	R:R:L45	4.87	No	No	0	4	7
22	R:R:F41	R:R:W342	5.01	No	No	0	4	5
23	R:R:S341	R:R:S42	3.26	No	No	1	8	9
24	R:R:I345	R:R:S42	4.64	Yes	No	1	9	9
25	R:R:M43	R:R:T44	3.01	Yes	No	0	8	6
26	R:R:G46	R:R:H88	7.94	No	Yes	1	9	9
27	R:R:G46	R:R:I345	7.05	No	Yes	1	9	9
28	R:R:P348	R:R:S49	7.13	No	No	0	9	9
29	R:R:S49	R:R:W349	9.88	No	No	0	9	9
30	R:R:D84	R:R:N50	6.73	Yes	Yes	0	9	9
31	R:R:L85	R:R:N50	4.12	No	Yes	0	9	9
32	R:R:H88	R:R:N50	5.1	Yes	Yes	0	9	9
33	R:R:N50	R:R:P348	8.15	Yes	No	0	9	9
34	R:R:L51	R:R:L85	4.15	No	No	0	5	9
35	R:R:L52	R:R:Q361	3.99	No	No	0	5	6
36	R:R:A53	R:R:L81	3.15	No	No	0	9	8
37	R:R:L54	R:R:L81	6.92	No	No	0	8	8
38	R:R:L56	R:R:Q361	7.99	No	No	0	8	6
39	R:R:L57	R:R:V77	4.47	No	No	0	9	8
40	R:R:I352	R:R:L57	5.71	No	No	0	9	9
41	R:R:Q59	R:R:R360	10.51	No	Yes	0	4	4
42	R:R:A61	R:R:R65	5.53	No	No	2	6	5
43	R:R:A61	R:R:L74	3.15	No	Yes	2	6	7
44	R:R:R360	R:R:R63	4.26	Yes	No	0	4	6
45	R:R:L74	R:R:R65	6.07	Yes	No	2	7	5
46	R:R:R68	R:R:V151	7.85	No	No	0	5	5
47	R:R:A70	R:R:L74	3.15	No	Yes	0	6	7
48	R:R:E134	R:R:T72	5.64	Yes	No	0	9	7
49	R:R:T72	R:R:V149	3.17	No	No	0	7	6
50	R:R:A154	R:R:T72	5.03	No	No	0	7	7
51	R:R:F73	R:R:L74	4.87	Yes	Yes	2	9	7
52	R:R:F73	R:R:V77	7.87	Yes	No	0	9	8
53	R:R:E134	R:R:F73	4.66	Yes	Yes	2	9	9
54	R:R:F73	R:R:R135	10.69	Yes	No	2	9	9
55	R:R:L75	R:R:R155	9.72	No	No	0	7	6
56	R:R:F76	R:R:M131	4.98	No	Yes	0	9	9
57	R:R:F76	R:R:L158	10.96	No	No	0	9	7
58	R:R:M131	R:R:V77	3.04	Yes	No	0	9	8
59	R:R:L127	R:R:S79	3	Yes	No	0	7	7
60	R:R:L158	R:R:S79	4.5	No	No	0	7	7
61	R:R:D84	R:R:L80	8.14	Yes	Yes	1	9	9
62	R:R:L127	R:R:L80	8.3	Yes	Yes	0	7	9
63	R:R:D347	R:R:L80	5.43	Yes	Yes	1	9	9
64	R:R:C123	R:R:T83	3.38	No	No	0	8	9
65	R:R:D84	R:R:P124	3.22	Yes	No	1	9	8
66	R:R:D84	R:R:Q344	7.83	Yes	Yes	1	9	9
67	R:R:D347	R:R:D84	6.65	Yes	Yes	1	9	9
68	R:R:A86	R:R:F120	5.55	No	Yes	0	6	8
69	R:R:G87	R:R:P91	4.06	No	No	0	8	7
70	R:R:F120	R:R:G87	9.03	Yes	No	0	8	8
71	R:R:H88	R:R:I345	5.3	Yes	Yes	1	9	9
72	R:R:I90	R:R:P91	6.77	No	No	5	7	7
73	R:R:C116	R:R:I90	3.27	No	No	5	5	7
74	R:R:C116	R:R:P91	5.65	No	No	5	5	7
75	R:R:G92	R:R:V95	3.68	No	No	1	9	9
76	R:R:L113	R:R:L94	5.54	No	No	0	8	7
77	R:R:L98	R:R:P105	6.57	No	Yes	0	7	5
78	R:R:T186	R:R:Y99	17.48	No	Yes	1	9	9
79	R:R:G108	R:R:H111	3.18	No	No	0	2	4
80	R:R:C110	R:R:L181	6.35	No	No	0	9	4
81	R:R:C110	R:R:C188	3.64	No	No	0	9	9
82	R:R:H111	R:R:Y179	3.27	No	Yes	0	4	6
83	R:R:C188	R:R:L113	4.76	No	No	0	9	8
84	R:R:G114	R:R:Y179	7.24	No	Yes	0	7	6
85	R:R:C188	R:R:G114	3.92	No	No	0	9	7
86	R:R:G115	R:R:Y179	4.35	No	Yes	0	7	6
87	R:R:V118	R:R:Y179	6.31	No	Yes	0	8	6
88	R:R:I190	R:R:V118	3.07	Yes	No	0	8	8
89	R:R:F119	R:R:F120	9.65	Yes	Yes	0	8	8
90	R:R:A165	R:R:F119	4.16	No	Yes	0	8	8
91	R:R:F119	R:R:L166	8.53	Yes	No	0	8	5
92	R:R:L122	R:R:V168	2.98	No	No	0	7	7
93	R:R:C123	R:R:L127	3.17	No	Yes	0	8	7
94	R:R:P124	R:R:Q344	9.47	No	Yes	1	8	9
95	R:R:L125	R:R:W310	17.08	No	Yes	0	7	9
96	R:R:L126	R:R:V161	7.45	No	No	0	7	5
97	R:R:L127	R:R:V161	2.98	Yes	No	0	7	5
98	R:R:G128	R:R:M131	3.49	No	Yes	0	8	9
99	R:R:M131	R:R:Y351	9.58	Yes	Yes	0	9	8
100	R:R:A132	R:R:N222	4.69	No	Yes	0	9	9
101	R:R:E134	R:R:R135	5.82	Yes	No	2	9	9
102	R:R:E134	R:R:H145	4.92	Yes	No	0	9	9
103	R:R:Q298	R:R:R135	9.35	No	No	0	8	9
104	R:R:C136	R:R:C221	3.64	No	No	0	7	8
105	R:R:C136	R:R:L224	3.17	No	No	0	7	5
106	R:R:C136	R:R:S225	3.44	No	No	0	7	9
107	R:R:G138	R:R:V137	3.68	No	No	0	9	7
108	R:R:G138	R:R:H145	9.53	No	No	0	9	9
109	R:R:L229	R:R:V139	2.98	Yes	No	0	9	8
110	R:R:L144	R:R:R141	3.64	No	Yes	0	5	6
111	R:R:L144	R:R:R148	3.64	No	No	0	5	4
112	R:R:L171	R:R:V168	5.96	Yes	No	0	8	7
113	R:R:L170	R:R:L173	4.15	No	No	0	6	4
114	R:R:L171	R:R:V176	4.47	Yes	No	0	8	6
115	R:R:L171	R:R:L203	5.54	Yes	Yes	0	8	6
116	R:R:P172	R:R:Y179	15.3	No	Yes	0	9	6
117	R:R:L203	R:R:P172	3.28	Yes	No	0	6	9
118	R:R:R199	R:R:V176	6.54	No	No	0	3	6
119	R:R:G177	R:R:R178	3	No	Yes	3	8	3
120	R:R:G177	R:R:Q200	3.29	No	Yes	3	8	4
121	R:R:G177	R:R:L203	3.42	No	Yes	0	8	6
122	R:R:E180	R:R:R178	9.3	No	Yes	3	5	3
123	R:R:G191	R:R:R178	4.5	No	Yes	3	5	3
124	R:R:G196	R:R:R178	6	No	Yes	0	3	3
125	R:R:Q200	R:R:R178	5.84	Yes	Yes	3	4	3
126	R:R:E180	R:R:G191	6.55	No	No	3	5	5
127	R:R:Q182	R:R:W187	20.81	No	Yes	1	9	9
128	R:R:F189	R:R:Q182	4.68	Yes	No	1	9	9
129	R:R:P184	R:R:Y183	12.52	No	No	0	9	4
130	R:R:Q330	R:R:Y183	14.65	No	No	0	3	4
131	R:R:P184	R:R:W187	9.46	No	Yes	1	9	9
132	R:R:F334	R:R:P184	17.34	Yes	No	1	8	9
133	R:R:F189	R:R:W187	5.01	Yes	Yes	1	9	9
134	R:R:F334	R:R:W187	8.02	Yes	Yes	1	8	9
135	R:R:V337	R:R:W187	9.81	No	Yes	1	8	9
136	R:R:F189	R:R:I190	8.79	Yes	Yes	0	9	8
137	R:R:F189	R:R:M313	3.73	Yes	Yes	0	9	8
138	R:R:I190	R:R:L203	11.42	Yes	Yes	0	8	6
139	R:R:F207	R:R:I190	3.77	No	Yes	0	9	8
140	R:R:L192	R:R:V317	2.98	No	No	0	8	7
141	R:R:A320	R:R:L192	4.73	No	No	0	7	8
142	R:R:G193	R:R:P194	4.06	No	No	0	4	3
143	R:R:G193	R:R:S326	3.71	No	No	0	4	1
144	R:R:R199	R:R:W198	15.99	No	No	0	3	2
145	R:R:L202	R:R:W198	3.42	No	No	0	5	2
146	R:R:A204	R:R:Q200	3.03	No	Yes	0	7	4
147	R:R:F207	R:R:L314	3.65	No	Yes	0	9	8
148	R:R:F207	R:R:V317	3.93	No	No	0	9	7
149	R:R:A208	R:R:V317	3.39	No	No	0	8	7
150	R:R:G211	R:R:L314	5.13	No	Yes	0	7	8
151	R:R:L212	R:R:L314	4.15	No	Yes	0	7	8
152	R:R:L215	R:R:W310	3.42	No	Yes	0	7	9
153	R:R:C307	R:R:L219	4.76	No	No	0	6	6
154	R:R:L299	R:R:N222	4.12	No	Yes	0	9	9
155	R:R:M303	R:R:N222	4.21	No	Yes	0	9	9
156	R:R:M303	R:R:T223	4.52	No	No	0	9	5
157	R:R:D292	R:R:L229	5.43	No	Yes	0	9	9
158	R:R:L229	R:R:V296	4.47	Yes	No	0	9	8
159	R:R:L230	R:R:W234	4.56	No	No	0	5	5
160	R:R:R231	R:R:W234	3	No	No	0	5	5
161	R:R:R233	R:R:R236	4.26	Yes	No	0	7	6
162	R:R:R233	R:R:R289	3.2	Yes	No	0	7	7
163	R:R:D292	R:R:R233	11.91	No	Yes	0	9	7
164	R:R:R235	R:R:W234	3	No	No	0	7	5
165	R:R:R235	R:R:R239	3.2	No	No	0	7	4
166	R:R:E294	R:R:R355	10.47	No	No	0	8	9
167	R:R:E294	R:R:Q356	10.19	No	No	0	8	7
168	R:R:L299	R:R:M295	7.07	No	No	0	9	9
169	R:R:I302	R:R:Q298	5.49	Yes	No	0	9	8
170	R:R:Q298	R:R:R355	19.86	No	No	0	8	9
171	R:R:M303	R:R:V300	3.04	No	No	0	9	7
172	R:R:I302	R:R:V350	3.07	Yes	Yes	1	9	8
173	R:R:I302	R:R:Y351	19.34	Yes	Yes	1	9	8
174	R:R:L346	R:R:V305	4.47	No	No	0	8	8
175	R:R:V305	R:R:V350	3.21	No	Yes	0	8	8
176	R:R:C309	R:R:I308	4.91	No	No	0	9	7
177	R:R:C309	R:R:N343	7.87	No	Yes	0	9	9
178	R:R:L314	R:R:W310	6.83	Yes	Yes	0	8	9
179	R:R:N343	R:R:W310	11.3	Yes	Yes	1	9	9
180	R:R:Q344	R:R:W310	8.76	Yes	Yes	1	9	9
181	R:R:P312	R:R:S311	3.56	No	No	0	9	7
182	R:R:L333	R:R:M313	4.24	No	Yes	0	8	8
183	R:R:A336	R:R:M313	3.22	No	Yes	0	7	8
184	R:R:M313	R:R:V337	4.56	Yes	No	0	8	8
185	R:R:L316	R:R:P332	3.28	Yes	No	0	6	3
186	R:R:L319	R:R:W324	11.39	No	No	0	4	3
187	R:R:L335	R:R:R331	7.29	No	No	0	4	4
188	R:R:F334	R:R:R338	17.1	Yes	No	1	8	9
189	R:R:I345	R:R:W342	4.7	Yes	No	0	9	5
190	R:R:N343	R:R:Q344	7.92	Yes	Yes	1	9	9
191	R:R:D347	R:R:N343	4.04	Yes	Yes	1	9	9
192	R:R:D347	R:R:Y351	3.45	Yes	Yes	1	9	8
193	R:R:L353	R:R:W349	13.67	No	No	0	8	9
194	R:R:V350	R:R:Y351	3.79	Yes	Yes	1	8	8
195	R:R:Q361	R:R:R364	9.35	No	No	0	6	6
196	R:R:L362	R:R:L366	6.92	No	No	0	4	5
197	R:R:L227	R:R:T223	2.95	No	No	0	4	5
198	R:R:A290	R:R:H291	2.93	No	No	0	6	7
199	R:R:I40	R:R:M43	2.92	No	Yes	0	7	8
200	R:R:P332	R:R:R331	2.88	No	No	0	3	4
201	R:R:L96	R:R:M43	2.83	No	Yes	0	8	8
202	R:R:I302	R:R:N222	2.83	Yes	Yes	0	9	9
203	R:R:L229	R:R:M295	2.83	Yes	No	0	9	9
204	R:R:L353	R:R:L52	2.77	No	No	0	8	5
205	R:R:L353	R:R:L56	2.77	No	No	0	8	8
206	R:R:L80	R:R:L81	2.77	Yes	No	0	9	8
207	R:R:R153	R:R:S150	2.64	No	No	0	5	7
208	R:R:R141	R:R:V137	2.62	Yes	No	0	6	7
209	R:R:R155	R:R:V151	2.62	No	No	0	6	5
210	R:R:F120	R:R:T83	2.59	Yes	No	0	8	9
211	R:R:R141	R:R:T140	2.59	Yes	No	0	6	8
212	R:R:A340	R:R:W310	2.59	No	Yes	0	9	9
213	R:R:F112	R:R:I90	2.51	No	No	0	5	7
214	R:R:L94	R:R:R97	2.43	No	No	0	7	7
215	R:R:L96	R:R:R97	2.43	No	No	0	8	7
216	R:R:L354	R:R:R355	2.43	No	No	0	7	9
217	R:R:R175	R:R:R199	2.13	No	No	0	6	3
218	R:R:R360	R:R:R364	2.13	Yes	No	4	4	6
219	R:R:G107	R:R:G108	2.11	No	No	0	1	2
220	R:R:G196	R:R:G197	2.11	No	No	0	3	4
221	R:R:G322	R:R:G323	2.11	No	No	0	4	6
222	R:R:C129	R:R:G130	1.96	Yes	No	0	5	9
223	R:R:A101	R:R:G102	1.95	No	No	0	4	5
224	R:R:P194	R:R:P195	1.95	No	No	0	3	3
225	R:R:A204	R:R:G205	1.95	No	No	0	7	4
226	R:R:C110	R:R:P105	1.88	No	Yes	0	9	5
227	R:R:A104	R:R:P105	1.87	No	Yes	0	4	5
228	R:R:A109	R:R:P105	1.87	No	Yes	0	6	5
229	R:R:A336	R:R:P312	1.87	No	No	0	7	9
230	R:R:G205	R:R:V321	1.84	No	No	0	4	5
231	R:R:G226	R:R:V296	1.84	No	No	0	7	8
232	R:R:G297	R:R:V300	1.84	No	No	0	6	7
233	R:R:G301	R:R:V300	1.84	No	No	0	5	7
234	R:R:G301	R:R:V304	1.84	No	No	0	5	5
235	R:R:G301	R:R:V350	1.84	No	Yes	0	5	8
236	R:R:A214	R:R:C129	1.81	No	Yes	0	7	5
237	R:R:A217	R:R:C129	1.81	No	Yes	0	5	5
238	R:R:A132	R:R:C221	1.81	No	No	0	9	8
239	R:R:A132	R:R:A218	1.79	No	No	0	9	8
240	R:R:A208	R:R:A318	1.79	No	No	0	8	5
241	R:R:P36	R:R:S35	1.78	No	No	0	6	6
242	R:R:C307	R:R:S311	1.72	No	No	0	6	7
243	R:R:A37	R:R:S35	1.71	No	No	0	5	6
244	R:R:C129	R:R:V133	1.71	Yes	No	0	5	7
245	R:R:C221	R:R:V133	1.71	No	No	0	8	7
246	R:R:G211	R:R:L210	1.71	No	No	0	7	5
247	R:R:A47	R:R:V89	1.7	No	No	0	7	6
248	R:R:A71	R:R:V151	1.7	No	No	0	7	5
249	R:R:A174	R:R:V176	1.7	No	No	0	4	6
250	R:R:L339	R:R:P312	1.64	No	No	0	6	9
251	R:R:S325	R:R:S328	1.63	No	No	7	2	4
252	R:R:V164	R:R:V168	1.6	No	No	0	4	7
253	R:R:V293	R:R:V296	1.6	No	No	0	6	8
254	R:R:S325	R:R:T327	1.6	No	No	7	2	2
255	R:R:S328	R:R:T327	1.6	No	No	7	4	2
256	R:R:T44	R:R:V48	1.59	No	No	0	6	5
257	R:R:A47	R:R:L85	1.58	No	No	0	7	9
258	R:R:A82	R:R:L54	1.58	No	No	0	6	8
259	R:R:A357	R:R:L56	1.58	No	No	0	6	8
260	R:R:A78	R:R:L57	1.58	No	No	0	7	9
261	R:R:A60	R:R:L64	1.58	No	No	0	8	3
262	R:R:A70	R:R:L64	1.58	No	No	0	6	3
263	R:R:A154	R:R:L75	1.58	No	No	0	7	7
264	R:R:A93	R:R:L94	1.58	No	No	0	9	7
265	R:R:A106	R:R:L181	1.58	No	No	0	5	4
266	R:R:A336	R:R:L316	1.58	No	Yes	0	7	6
267	R:R:A201	R:R:Q200	1.52	No	Yes	0	5	4
268	R:R:L210	R:R:S209	1.5	No	No	0	5	5
269	R:R:L215	R:R:S306	1.5	No	No	0	7	9
270	R:R:L219	R:R:S306	1.5	No	No	0	6	9
271	R:R:L212	R:R:V315	1.49	No	No	0	7	7
272	R:R:L224	R:R:V220	1.49	No	No	0	5	3
273	R:R:P142	R:R:R141	1.44	No	Yes	0	8	6
274	R:R:A157	R:R:F76	1.39	No	No	0	6	9
275	R:R:A169	R:R:F119	1.39	No	Yes	0	8	8
276	R:R:A101	R:R:R103	1.38	No	No	0	4	3
277	R:R:L171	R:R:L206	1.38	Yes	No	0	8	4
278	R:R:A228	R:R:R231	1.38	No	No	0	7	5
279	R:R:A288	R:R:R233	1.38	No	Yes	0	5	7
280	R:R:L316	R:R:L319	1.38	Yes	No	6	6	4
281	R:R:L316	R:R:L329	1.38	Yes	No	6	6	2
282	R:R:L319	R:R:L329	1.38	No	No	6	4	2
283	R:R:L329	R:R:L333	1.38	No	No	0	2	8
284	R:R:A34	R:R:Y99	1.33	No	Yes	0	3	9
285	R:R:R235	R:R:S238	1.32	No	No	0	7	4
286	R:R:L363	R:R:R360	1.21	No	Yes	4	2	4
287	R:R:L363	R:R:R364	1.21	No	No	4	2	6
288	R:R:R65	R:R:R66	1.07	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.02937	16	1	0
2	R:R:M43	2.9825	4	0	8
3	R:R:N50	6.025	4	0	9
4	R:R:F73	7.0225	4	2	9
5	R:R:L74	4.31	4	2	7
6	R:R:L80	6.16	4	1	9
7	R:R:D84	6.514	5	1	9
8	R:R:H88	6.5075	4	1	9
9	R:R:Y99	7.316	5	1	9
10	R:R:P105	3.0475	4	0	5
11	R:R:F119	5.9325	4	0	8
12	R:R:F120	6.705	4	0	8
13	R:R:L127	4.3625	4	0	7
14	R:R:C129	1.8225	4	0	5
15	R:R:M131	5.2725	4	0	9
16	R:R:E134	5.26	4	2	9
17	R:R:R141	2.5725	4	0	6
18	R:R:L171	4.3375	4	0	8
19	R:R:R178	5.728	5	3	3
20	R:R:Y179	7.294	5	0	6
21	R:R:W187	9.70333	6	1	9
22	R:R:F189	5.5525	4	1	9
23	R:R:I190	6.7625	4	0	8
24	R:R:Q200	3.42	4	3	4
25	R:R:L203	5.915	4	0	6
26	R:R:N222	3.9625	4	0	9
27	R:R:L229	3.9275	4	0	9
28	R:R:R233	5.1875	4	0	7
29	R:R:I302	7.6825	4	1	9
30	R:R:W310	8.33	6	1	9
31	R:R:M313	3.9375	4	0	8
32	R:R:L314	4.94	4	0	8
33	R:R:L316	1.905	4	6	6
34	R:R:F334	11.98	4	1	8
35	R:R:N343	7.7825	4	1	9
36	R:R:Q344	8.588	5	1	9
37	R:R:I345	5.4225	4	1	9
38	R:R:D347	4.8925	4	1	9
39	R:R:V350	2.9775	4	1	8
40	R:R:Y351	9.04	4	1	8
41	R:R:R360	4.5275	4	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H88	13.0936	7.69	Yes	Yes	1	0	9
2	L:L:?1	R:R:M43	23.6151	3.17	Yes	Yes	0	0	8
3	R:R:H88	R:R:N50	13.8332	5.1	Yes	Yes	0	9	9
4	R:R:N50	R:R:P348	21.0335	8.15	Yes	No	0	9	9
5	R:R:P348	R:R:S49	19.9637	7.13	No	No	0	9	9
6	R:R:S49	R:R:W349	18.8846	9.88	No	No	0	9	9
7	L:L:?1	R:R:Q344	65.1798	8.96	Yes	Yes	1	0	9
8	R:R:D84	R:R:Q344	43.709	7.83	Yes	Yes	1	9	9
9	R:R:L353	R:R:W349	17.7962	13.67	No	No	0	8	9
10	R:R:D84	R:R:L80	18.7497	8.14	Yes	Yes	1	9	9
11	R:R:D347	R:R:D84	39.0762	6.65	Yes	Yes	1	9	9
12	R:R:D347	R:R:Y351	100	3.45	Yes	Yes	1	9	8
13	R:R:M131	R:R:Y351	37.6343	9.58	Yes	Yes	0	9	8
14	R:R:M131	R:R:V77	35.1133	3.04	Yes	No	0	9	8
15	R:R:N343	R:R:Q344	26.5129	7.92	Yes	Yes	1	9	9
16	R:R:D347	R:R:N343	58.9702	4.04	Yes	Yes	1	9	9
17	R:R:Q361	R:R:R364	11.3959	9.35	No	No	0	6	6
18	R:R:F73	R:R:V77	30.3503	7.87	Yes	No	0	9	8
19	R:R:F73	R:R:L74	10.3772	4.87	Yes	Yes	2	9	7
20	R:R:E134	R:R:F73	21.1498	4.66	Yes	Yes	2	9	9
21	R:R:E134	R:R:T72	20.2568	5.64	Yes	No	0	9	7
22	R:R:A154	R:R:T72	15.6519	5.03	No	No	0	7	7
23	R:R:A154	R:R:L75	13.0657	1.58	No	No	0	7	7
24	R:R:L75	R:R:R155	10.4703	9.72	No	No	0	7	6
25	R:R:I302	R:R:Y351	57.4585	19.34	Yes	Yes	1	9	8
26	R:R:I302	R:R:Q298	30.2107	5.49	Yes	No	0	9	8
27	R:R:Q298	R:R:R135	24.4476	9.35	No	No	0	8	9
28	R:R:E134	R:R:R135	21.7824	5.82	Yes	No	2	9	9
29	R:R:L127	R:R:L80	26.7129	8.3	Yes	Yes	0	7	9
30	R:R:C123	R:R:L127	21.9685	3.17	No	Yes	0	8	7
31	R:R:C123	R:R:T83	20.3219	3.38	No	No	0	8	9
32	R:R:F120	R:R:T83	18.666	2.59	Yes	No	0	8	9
33	R:R:L96	R:R:M43	17.3589	2.83	No	Yes	0	8	8
34	R:R:L96	R:R:R97	16.0147	2.43	No	No	0	8	7
35	R:R:L94	R:R:R97	14.5914	2.43	No	No	0	7	7
36	R:R:L113	R:R:L94	12.1168	5.54	No	No	0	8	7
37	R:R:C188	R:R:L113	11.0098	4.76	No	No	0	9	8
38	R:R:C110	R:R:C188	14.6798	3.64	No	No	0	9	9
39	L:L:?1	R:R:W187	20.4335	5.11	Yes	Yes	1	0	9
40	R:R:F189	R:R:W187	16.0147	5.01	Yes	Yes	1	9	9
41	R:R:F189	R:R:I190	19.0427	8.79	Yes	Yes	0	9	8
42	R:R:I190	R:R:V118	14.1262	3.07	Yes	No	0	8	8
43	R:R:V118	R:R:Y179	12.9773	6.31	No	Yes	0	8	6
44	R:R:I190	R:R:L203	30.6619	11.42	Yes	Yes	0	8	6
45	R:R:L171	R:R:L203	15.6565	5.54	Yes	Yes	0	8	6
46	R:R:Q344	R:R:W310	12.1448	8.76	Yes	Yes	1	9	9
47	R:R:I302	R:R:N222	36.5412	2.83	Yes	Yes	0	9	9
48	R:R:A132	R:R:N222	16.9636	4.69	No	Yes	0	9	9
49	R:R:E134	R:R:H145	20.7963	4.92	Yes	No	0	9	9
50	R:R:A132	R:R:C221	14.2286	1.81	No	No	0	9	8
51	R:R:G138	R:R:H145	18.2288	9.53	No	No	0	9	9
52	R:R:G138	R:R:V137	15.6519	3.68	No	No	0	9	7
53	R:R:R141	R:R:V137	13.0657	2.62	Yes	No	0	6	7
54	R:R:G177	R:R:L203	15.7031	3.42	No	Yes	0	8	6
55	L:L:?1	R:R:V337	19.9172	6.68	Yes	No	1	0	8
56	R:R:M313	R:R:V337	19.3311	4.56	Yes	No	0	8	8
57	R:R:F207	R:R:I190	30.8666	3.77	No	Yes	0	9	8
58	R:R:L314	R:R:W310	38.3692	6.83	Yes	Yes	0	8	9
59	R:R:F207	R:R:L314	34.0434	3.65	No	Yes	0	9	8
60	R:R:A336	R:R:M313	15.717	3.22	No	Yes	0	7	8
61	R:R:L299	R:R:N222	16.2519	4.12	No	Yes	0	9	9
62	R:R:L299	R:R:M295	14.8751	7.07	No	No	0	9	9
63	R:R:L229	R:R:M295	13.6518	2.83	Yes	No	0	9	9
64	R:R:D84	R:R:N50	19.0474	6.73	Yes	Yes	0	9	9
65	R:R:D347	R:R:L80	15.0519	5.43	Yes	Yes	1	9	9
66	R:R:N343	R:R:W310	32.6201	11.3	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:P39	4.91	1	Yes	No	0	8	0	1
L:L:?1	R:R:S42	5.61	1	Yes	No	0	9	0	1
L:L:?1	R:R:M43	3.17	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:H88	7.69	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G92	5.12	1	Yes	No	0	9	0	1
L:L:?1	R:R:V95	11.14	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y99	5.26	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:M117	14.8	1	Yes	No	0	9	0	1
L:L:?1	R:R:G121	3.84	1	Yes	No	0	7	0	1
L:L:?1	R:R:T186	4.41	1	Yes	No	0	9	0	1
L:L:?1	R:R:W187	5.11	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F334	5.46	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V337	6.68	1	Yes	No	0	8	0	1
L:L:?1	R:R:R338	9.08	1	Yes	No	0	9	0	1
L:L:?1	R:R:S341	11.23	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q344	8.96	1	Yes	Yes	0	9	0	1
R:R:P36	R:R:Y99	4.17	0	No	Yes	6	9	2	1
R:R:L38	R:R:R338	10.93	0	No	No	6	9	2	1
R:R:P39	R:R:V95	3.53	1	No	No	8	9	1	1
R:R:P39	R:R:Y99	8.34	1	No	Yes	8	9	1	1
R:R:S341	R:R:S42	3.26	1	No	No	8	9	1	1
R:R:I345	R:R:S42	4.64	1	Yes	No	9	9	2	1
R:R:M43	R:R:T44	3.01	0	Yes	No	8	6	1	2
R:R:G46	R:R:H88	7.94	1	No	Yes	9	9	2	1
R:R:G46	R:R:I345	7.05	1	No	Yes	9	9	2	2
R:R:D84	R:R:N50	6.73	1	Yes	Yes	9	9	2	2
R:R:H88	R:R:N50	5.1	1	Yes	Yes	9	9	1	2
R:R:D84	R:R:P124	3.22	1	Yes	No	9	8	2	2
R:R:D84	R:R:Q344	7.83	1	Yes	Yes	9	9	2	1
R:R:H88	R:R:I345	5.3	1	Yes	Yes	9	9	1	2
R:R:G92	R:R:V95	3.68	1	No	No	9	9	1	1
R:R:T186	R:R:Y99	17.48	1	No	Yes	9	9	1	1
R:R:P124	R:R:Q344	9.47	1	No	Yes	8	9	2	1
R:R:Q182	R:R:W187	20.81	1	No	Yes	9	9	2	1
R:R:F189	R:R:Q182	4.68	1	Yes	No	9	9	2	2
R:R:P184	R:R:W187	9.46	1	No	Yes	9	9	2	1
R:R:F334	R:R:P184	17.34	1	Yes	No	8	9	1	2
R:R:F189	R:R:W187	5.01	1	Yes	Yes	9	9	2	1
R:R:F334	R:R:W187	8.02	1	Yes	Yes	8	9	1	1
R:R:V337	R:R:W187	9.81	1	No	Yes	8	9	1	1
R:R:F189	R:R:M313	3.73	1	Yes	Yes	9	8	2	2
R:R:N343	R:R:W310	11.3	1	Yes	Yes	9	9	2	2
R:R:Q344	R:R:W310	8.76	1	Yes	Yes	9	9	1	2
R:R:M313	R:R:V337	4.56	0	Yes	No	8	8	2	1
R:R:F334	R:R:R338	17.1	1	Yes	No	8	9	1	1
R:R:N343	R:R:Q344	7.92	1	Yes	Yes	9	9	2	1
R:R:I40	R:R:M43	2.92	0	No	Yes	7	8	2	1
R:R:L96	R:R:M43	2.83	0	No	Yes	8	8	2	1
R:R:A34	R:R:Y99	1.33	0	No	Yes	3	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M1H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	262
Number of Links	288
Number of Hubs	41
Number of Links mediated by Hubs	150
Number of Communities	7
Number of Nodes involved in Communities	51
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	41973
Length Of Smallest Path	3
Average Path Length	12.0583
Length of Longest Path	24
Minimum Path Strength	1.38
Average Path Strength	5.93235
Maximum Path Strength	17.22
Minimum Path Correlation	0.7
Average Path Correlation	0.930659
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	55.7255
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.0217
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • phospholipase C-activating G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • cell periphery • cellular anatomical structure • plasma membrane • membrane • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • regulation of circadian rhythm • glutamate receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • cellular response to ketone • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P2E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P2E
Name	Dinoprostone
Synonyms	Dinoprostona
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	5280360
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34995
Sequence	>9M1H_nogp_Chain_R A S P A L P I F S M T L G A V S N L L A L A L L A Q A A G R L R R R R S A A T F L L F V A S L L A T D L A G H V I P G A L V L R L Y T A G R A P A G G A C H F L G G C M V F F G L C P L L L G C G M A V E R C V G V T R P L L H A A R V S V A R A R L A L A A V A A V A L A V A L L P L A R V G R Y E L Q Y P G T W C F I G L G P P G G W R Q A L L A G L F A S L G L V A L L A A L V C N T L S G L A L L R A R W R R R S R R A R A H D V E M V G Q L V G I M V V S C I C W S P M L V L V A L A V G G W S S T S L Q R P L F L A V R L A S W N Q I L D P W V Y I L L R Q A V L R Q L L R L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9M1H	A	Lipid	Prostanoid	EP₁	Homo sapiens	Prostaglandin E2	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-04-09	To be published
	9M1H (No Gprot)	A	Lipid	Prostanoid	EP₁	Homo sapiens	Prostaglandin E2	-		2.55	2025-04-09	To be published

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