psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R69	R:R:D404	13.1	Yes	No	0	0	4
2	L:L:R69	R:R:P405	7.21	Yes	No	0	0	4
3	L:L:A70	R:R:K175	8.03	No	No	0	0	5
4	L:L:S71	R:R:M414	6.13	No	No	0	0	2
5	L:L:K72	R:R:Q85	12.2	Yes	No	0	0	5
6	L:L:K72	R:R:G86	3.49	Yes	No	7	0	7
7	L:L:K72	R:R:R171	11.14	Yes	Yes	7	0	1
8	L:L:L73	L:L:R77	10.93	No	Yes	0	0	0
9	L:L:G74	R:R:H418	3.18	No	Yes	0	0	4
10	L:L:L75	R:R:S78	6.01	No	No	0	0	8
11	L:L:L75	R:R:H81	12.86	No	No	0	0	7
12	L:L:L75	R:R:I102	2.85	No	Yes	0	0	8
13	L:L:A76	R:R:M106	3.22	No	Yes	0	0	9
14	L:L:A76	R:R:I421	3.25	No	No	0	0	4
15	L:L:R77	R:R:Y393	7.2	Yes	Yes	3	0	9
16	L:L:R77	R:R:D417	15.48	Yes	No	3	0	8
17	L:L:R77	R:R:I421	3.76	Yes	No	3	0	4
18	R:R:E20	R:R:W18	21.81	Yes	No	4	4	1
19	R:R:V23	R:R:W18	9.81	Yes	No	4	4	1
20	R:R:Q85	R:R:W18	13.14	No	No	0	5	1
21	R:R:E20	R:R:P22	3.14	Yes	Yes	0	4	4
22	R:R:E20	R:R:V23	8.56	Yes	Yes	4	4	4
23	R:R:P21	R:R:P22	5.84	No	Yes	0	6	4
24	R:R:P22	R:R:S415	3.56	Yes	No	0	4	5
25	R:R:P22	R:R:W416	8.11	Yes	No	0	4	7
26	R:R:L82	R:R:V23	7.45	Yes	Yes	4	7	4
27	R:R:H418	R:R:V23	4.15	Yes	Yes	4	4	4
28	R:R:I24	R:R:M27	2.92	No	No	0	7	6
29	R:R:L82	R:R:S26	3	Yes	No	0	7	8
30	R:R:S26	R:R:V419	3.23	No	No	0	8	5
31	R:R:I29	R:R:T33	3.04	No	Yes	0	7	8
32	R:R:A422	R:R:I29	4.87	No	No	0	8	7
33	R:R:L30	R:R:T33	5.9	Yes	Yes	5	6	8
34	R:R:L30	R:R:L75	13.84	Yes	Yes	5	6	9
35	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
36	R:R:L30	R:R:S425	3	Yes	No	0	6	8
37	R:R:L79	R:R:S31	3	No	No	0	6	7
38	R:R:L75	R:R:T33	2.95	Yes	Yes	5	9	8
39	R:R:C429	R:R:T33	3.38	No	Yes	0	9	8
40	R:R:F34	R:R:L35	6.09	No	No	0	7	6
41	R:R:F34	R:R:L38	7.31	No	No	0	7	7
42	R:R:C429	R:R:L36	6.35	No	No	0	9	8
43	R:R:G37	R:R:N41	5.09	No	Yes	0	9	9
44	R:R:L38	R:R:P39	3.28	No	No	0	7	7
45	R:R:G40	R:R:P432	4.06	No	Yes	0	9	9
46	R:R:D68	R:R:N41	5.39	Yes	Yes	0	9	9
47	R:R:L69	R:R:N41	5.49	No	Yes	0	7	9
48	R:R:C72	R:R:N41	6.3	No	Yes	0	8	9
49	R:R:N41	R:R:P432	8.15	Yes	Yes	0	9	9
50	R:R:A446	R:R:L43	4.73	No	No	0	8	8
51	R:R:T65	R:R:V44	7.93	No	Yes	0	9	9
52	R:R:P432	R:R:V44	3.53	Yes	Yes	0	9	9
53	R:R:A436	R:R:V44	5.09	No	Yes	8	8	9
54	R:R:F442	R:R:V44	3.93	Yes	Yes	8	9	9
55	R:R:L45	R:R:T65	2.95	No	No	0	8	9
56	R:R:L50	R:R:W46	6.83	No	No	0	4	6
57	R:R:F442	R:R:V47	6.55	Yes	Yes	0	9	8
58	R:R:K445	R:R:V47	7.59	No	Yes	0	7	8
59	R:R:A48	R:R:L62	3.15	No	No	0	7	8
60	R:R:A48	R:R:F442	5.55	No	Yes	0	7	9
61	R:R:G49	R:R:R54	4.5	No	No	9	7	7
62	R:R:G49	R:R:L62	3.42	No	No	9	7	8
63	R:R:K445	R:R:K51	5.75	No	No	0	7	9
64	R:R:M52	R:R:T58	6.02	No	No	0	9	8
65	R:R:D441	R:R:M52	4.16	No	No	0	7	9
66	R:R:K445	R:R:M52	8.64	No	No	0	7	9
67	R:R:L62	R:R:R54	4.86	No	No	9	8	7
68	R:R:N57	R:R:T55	10.24	No	No	10	8	9
69	R:R:T55	R:R:T58	4.71	No	No	10	9	8
70	R:R:V56	R:R:W60	3.68	Yes	Yes	0	8	8
71	R:R:R134	R:R:V56	7.85	Yes	Yes	0	9	8
72	R:R:V136	R:R:V56	3.21	No	Yes	0	7	8
73	R:R:A139	R:R:V56	5.09	No	Yes	0	7	8
74	R:R:N57	R:R:T58	4.39	No	No	10	8	8
75	R:R:H63	R:R:I59	3.98	No	No	0	8	6
76	R:R:C140	R:R:I59	3.27	No	No	0	4	6
77	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
78	R:R:I116	R:R:W60	3.52	Yes	Yes	0	9	8
79	R:R:D119	R:R:W60	10.05	No	Yes	0	9	8
80	R:R:I142	R:R:W60	3.52	No	Yes	0	5	8
81	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
82	R:R:F61	R:R:I116	3.77	No	Yes	0	8	9
83	R:R:F442	R:R:F61	10.72	Yes	No	0	9	8
84	R:R:C143	R:R:H63	14.74	No	No	0	8	8
85	R:R:H63	R:R:W147	7.41	No	Yes	0	8	9
86	R:R:D68	R:R:L64	5.43	Yes	Yes	1	9	9
87	R:R:L64	R:R:S109	3	Yes	Yes	1	9	9
88	R:R:L112	R:R:L64	4.15	No	Yes	0	9	9
89	R:R:L113	R:R:L64	5.54	Yes	Yes	1	8	9
90	R:R:L64	R:R:N431	5.49	Yes	Yes	1	9	9
91	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
92	R:R:A67	R:R:W147	3.89	No	Yes	0	9	9
93	R:R:D68	R:R:S109	7.36	Yes	Yes	1	9	9
94	R:R:D68	R:R:S428	5.89	Yes	No	0	9	9
95	R:R:D68	R:R:N431	12.12	Yes	Yes	1	9	9
96	R:R:L69	R:R:L73	4.15	No	No	0	7	8
97	R:R:I101	R:R:L70	2.85	Yes	No	0	5	6
98	R:R:L70	R:R:N105	5.49	No	No	0	6	9
99	R:R:C71	R:R:N105	11.02	No	No	0	8	9
100	R:R:C71	R:R:M106	3.24	No	Yes	0	8	9
101	R:R:C71	R:R:S428	6.89	No	No	0	8	9
102	R:R:I101	R:R:S74	6.19	Yes	No	2	5	9
103	R:R:I102	R:R:S74	4.64	Yes	No	2	8	9
104	R:R:L75	R:R:P76	4.93	Yes	No	0	9	9
105	R:R:F77	R:R:Y90	8.25	No	Yes	0	8	7
106	R:R:F77	R:R:I98	13.82	No	Yes	0	8	8
107	R:R:H81	R:R:R171	30.47	No	Yes	0	7	1
108	R:R:H418	R:R:L82	6.43	Yes	Yes	4	4	7
109	R:R:H418	R:R:Q85	4.95	Yes	No	0	4	5
110	R:R:G86	R:R:R171	9.01	No	Yes	7	7	1
111	R:R:H169	R:R:Q87	24.73	No	No	0	3	6
112	R:R:P89	R:R:W88	6.76	No	Yes	2	8	9
113	R:R:W88	R:R:Y90	19.29	Yes	Yes	2	9	7
114	R:R:L94	R:R:W88	3.42	Yes	Yes	2	8	9
115	R:R:C95	R:R:W88	9.14	Yes	Yes	2	9	9
116	R:R:I98	R:R:W88	3.52	Yes	Yes	2	8	9
117	R:R:I163	R:R:W88	3.52	No	Yes	0	6	9
118	R:R:C172	R:R:W88	7.84	No	Yes	2	8	9
119	R:R:P89	R:R:Y90	18.08	No	Yes	2	8	7
120	R:R:L94	R:R:Y90	12.89	Yes	Yes	2	8	7
121	R:R:K96	R:R:R92	3.71	No	No	0	8	1
122	R:R:I98	R:R:L94	2.85	Yes	Yes	2	8	8
123	R:R:C95	R:R:P99	3.77	Yes	No	2	9	8
124	R:R:C95	R:R:R161	4.18	Yes	Yes	2	9	8
125	R:R:C172	R:R:C95	7.28	No	Yes	2	8	9
126	R:R:F158	R:R:K96	11.17	No	No	0	8	8
127	R:R:I98	R:R:P99	10.16	Yes	No	2	8	8
128	R:R:I102	R:R:I98	4.42	Yes	Yes	2	8	8
129	R:R:P99	R:R:R161	15.85	No	Yes	2	8	8
130	R:R:C154	R:R:S100	3.44	Yes	No	0	8	8
131	R:R:S100	R:R:V157	3.23	No	No	0	8	9
132	R:R:I101	R:R:I102	2.94	Yes	Yes	2	5	8
133	R:R:C154	R:R:V103	5.12	Yes	No	0	8	5
134	R:R:R340	R:R:V103	5.23	No	No	0	9	5
135	R:R:L104	R:R:W147	4.56	No	Yes	0	8	9
136	R:R:C154	R:R:L104	4.76	Yes	No	0	8	8
137	R:R:M106	R:R:W390	6.98	Yes	Yes	3	9	9
138	R:R:M106	R:R:Y393	4.79	Yes	Yes	3	9	9
139	R:R:F107	R:R:R340	12.83	No	No	0	8	9
140	R:R:A108	R:R:W147	7.78	No	Yes	0	9	9
141	R:R:L113	R:R:S109	3	Yes	Yes	1	8	9
142	R:R:N431	R:R:S109	4.47	Yes	Yes	1	9	9
143	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
144	R:R:V110	R:R:W390	6.13	No	Yes	0	9	9
145	R:R:F111	R:R:V343	3.93	Yes	No	0	8	4
146	R:R:I146	R:R:L112	4.28	No	No	0	8	9
147	R:R:L113	R:R:N431	6.87	Yes	Yes	1	8	9
148	R:R:L113	R:R:Y435	15.24	Yes	Yes	1	8	9
149	R:R:P348	R:R:T114	6.99	Yes	No	0	9	8
150	R:R:I351	R:R:T114	4.56	No	No	0	6	8
151	R:R:I116	R:R:R120	7.52	Yes	No	1	9	9
152	R:R:I116	R:R:Y435	3.63	Yes	Yes	1	9	9
153	R:R:L118	R:R:S117	3	No	Yes	1	8	9
154	R:R:M352	R:R:S117	4.6	No	Yes	1	8	9
155	R:R:C355	R:R:S117	5.16	No	Yes	1	9	9
156	R:R:S117	R:R:Y356	3.82	Yes	Yes	1	9	9
157	R:R:I351	R:R:L118	4.28	No	No	0	6	8
158	R:R:C355	R:R:L118	3.17	No	No	1	9	8
159	R:R:D119	R:R:V123	5.84	No	No	6	9	5
160	R:R:D119	R:R:R134	14.29	No	Yes	6	9	9
161	R:R:R120	R:R:Y356	8.23	No	Yes	1	9	9
162	R:R:R120	R:R:Y435	4.12	No	Yes	1	9	9
163	R:R:C121	R:R:C355	7.28	No	No	0	9	9
164	R:R:C121	R:R:I359	3.27	No	No	0	9	9
165	R:R:C130	R:R:L122	4.76	No	No	0	7	7
166	R:R:C130	R:R:V123	3.42	No	No	6	7	5
167	R:R:R134	R:R:V123	6.54	Yes	No	6	9	5
168	R:R:I128	R:R:P127	5.08	No	No	0	7	9
169	R:R:H133	R:R:W129	20.1	No	No	0	8	6
170	R:R:C130	R:R:R134	5.57	No	Yes	6	7	9
171	R:R:H133	R:R:N132	3.83	No	No	0	8	8
172	R:R:G137	R:R:N135	3.39	No	No	0	5	5
173	R:R:I142	R:R:M138	2.92	No	No	0	5	6
174	R:R:I142	R:R:I146	2.94	No	No	0	5	8
175	R:R:M153	R:R:V343	4.56	No	No	0	8	4
176	R:R:I155	R:R:P156	5.08	No	No	0	5	9
177	R:R:F158	R:R:I155	5.02	No	No	0	8	5
178	R:R:R161	R:R:V157	3.92	Yes	No	0	8	9
179	R:R:Y160	R:R:Y174	4.96	No	No	0	8	7
180	R:R:C172	R:R:R161	4.18	No	Yes	2	8	8
181	R:R:R161	R:R:Y174	10.29	Yes	No	0	8	7
182	R:R:I163	R:R:N170	4.25	No	No	0	6	4
183	R:R:F164	R:R:T165	6.49	No	No	0	3	4
184	R:R:F164	R:R:T166	9.08	No	No	0	3	1
185	R:R:H169	R:R:N168	8.93	No	No	0	3	5
186	R:R:G173	R:R:Y174	2.9	No	No	0	1	7
187	R:R:P332	R:R:T331	5.25	No	No	0	4	4
188	R:R:L333	R:R:V334	2.98	No	No	0	3	4
189	R:R:I338	R:R:V334	3.07	No	No	0	6	4
190	R:R:L401	R:R:V334	7.45	No	No	0	7	4
191	R:R:L401	R:R:T337	4.42	No	No	0	7	7
192	R:R:R340	R:R:Y393	6.17	No	Yes	0	9	9
193	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
194	R:R:F345	R:R:T391	3.89	No	No	0	9	6
195	R:R:F345	R:R:H394	19.23	No	Yes	0	9	9
196	R:R:L347	R:R:P348	3.28	No	Yes	0	7	9
197	R:R:I351	R:R:L347	4.28	No	No	0	6	7
198	R:R:M352	R:R:Y356	7.18	No	Yes	1	8	9
199	R:R:M352	R:R:Y435	3.59	No	Yes	1	8	9
200	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
201	R:R:V382	R:R:Y356	5.05	Yes	Yes	1	8	9
202	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
203	R:R:F358	R:R:S357	5.28	No	No	0	6	6
204	R:R:M363	R:R:V360	9.13	No	No	0	7	6
205	R:R:F361	R:R:Q364	9.37	No	No	0	4	5
206	R:R:R362	R:R:R365	11.73	No	No	0	7	4
207	R:R:F368	R:R:R362	6.41	No	No	0	5	7
208	R:R:M363	R:R:Q372	12.23	No	No	0	7	5
209	R:R:M363	R:R:T375	13.55	No	No	0	7	7
210	R:R:Q364	R:R:R365	5.84	No	No	0	5	4
211	R:R:G366	R:R:R365	3	No	No	0	2	4
212	R:R:K370	R:R:R367	14.85	No	No	0	7	6
213	R:R:K370	R:R:S371	9.18	No	No	0	7	7
214	R:R:K374	R:R:S371	6.12	No	No	0	9	7
215	R:R:F376	R:R:V380	9.18	No	No	0	4	3
216	R:R:R377	R:R:V380	5.23	No	No	0	5	3
217	R:R:R377	R:R:V381	6.54	No	No	0	5	7
218	R:R:L438	R:R:V378	2.98	No	No	0	7	8
219	R:R:V381	R:R:V382	3.21	No	Yes	1	7	8
220	R:R:L434	R:R:V381	2.98	Yes	No	1	9	7
221	R:R:L434	R:R:V382	5.96	Yes	Yes	1	9	8
222	R:R:V382	R:R:Y435	5.05	Yes	Yes	1	8	9
223	R:R:L387	R:R:V383	2.98	No	No	0	6	8
224	R:R:F430	R:R:V385	5.24	No	No	0	7	7
225	R:R:L434	R:R:V385	4.47	Yes	No	0	9	7
226	R:R:F386	R:R:L387	6.09	No	No	0	9	6
227	R:R:F386	R:R:W390	7.02	No	Yes	0	9	9
228	R:R:L387	R:R:T391	2.95	No	No	0	6	6
229	R:R:C389	R:R:N427	9.45	No	No	0	9	9
230	R:R:W390	R:R:Y393	6.75	Yes	Yes	3	9	9
231	R:R:H394	R:R:W390	6.35	Yes	Yes	3	9	9
232	R:R:A424	R:R:W390	3.89	No	Yes	3	9	9
233	R:R:N427	R:R:W390	12.43	No	Yes	0	9	9
234	R:R:P392	R:R:T391	5.25	No	No	0	9	6
235	R:R:H394	R:R:Y393	5.44	Yes	Yes	3	9	9
236	R:R:A424	R:R:Y393	4	No	Yes	3	9	9
237	R:R:I395	R:R:L399	4.28	No	No	0	5	9
238	R:R:F396	R:R:L413	8.53	No	No	0	4	7
239	R:R:C420	R:R:F396	9.78	No	No	0	6	4
240	R:R:L399	R:R:L413	4.15	No	No	0	9	7
241	R:R:M414	R:R:P405	6.71	No	No	0	2	4
242	R:R:P408	R:R:T407	3.5	No	No	0	4	7
243	R:R:G410	R:R:T407	3.64	No	No	0	3	7
244	R:R:L409	R:R:L413	8.3	No	No	0	3	7
245	R:R:K411	R:R:S415	4.59	No	No	0	2	5
246	R:R:T412	R:R:W416	4.85	No	No	0	6	7
247	R:R:D417	R:R:I421	7	No	No	3	8	4
248	R:R:N427	R:R:N431	10.9	No	Yes	0	9	9
249	R:R:F433	R:R:L437	4.87	No	No	0	6	7
250	R:R:L434	R:R:Y435	7.03	Yes	Yes	1	9	9
251	R:R:A436	R:R:F442	6.93	No	Yes	8	8	9
252	R:R:D441	R:R:F442	9.55	No	Yes	0	7	9
253	R:R:K444	R:R:Q448	13.56	No	No	0	5	7
254	R:R:L82	R:R:M27	2.83	Yes	No	0	7	6
255	R:R:M138	R:R:N135	2.8	No	No	0	6	5
256	R:R:C121	R:R:F358	2.79	No	No	0	9	6
257	R:R:C429	R:R:F430	2.79	No	No	0	9	7
258	R:R:L30	R:R:L79	2.77	Yes	No	5	6	6
259	R:R:L32	R:R:L36	2.77	No	No	0	6	8
260	R:R:L66	R:R:L70	2.77	No	No	0	4	6
261	R:R:L75	R:R:L79	2.77	Yes	No	5	9	6
262	R:R:A150	R:R:F111	2.77	No	Yes	0	9	8
263	R:R:A426	R:R:F430	2.77	No	No	0	8	7
264	R:R:D167	R:R:N168	2.69	No	No	0	3	5
265	L:L:R69	R:R:S400	2.64	Yes	No	0	0	2
266	R:R:N132	R:R:Q131	2.64	No	No	0	8	9
267	R:R:F345	R:R:S349	2.64	No	Yes	0	9	4
268	R:R:F386	R:R:S349	2.64	No	Yes	0	9	4
269	R:R:F111	R:R:V149	2.62	Yes	No	0	8	4
270	R:R:R362	R:R:V124	2.62	No	No	0	7	9
271	R:R:F376	R:R:V360	2.62	No	No	0	4	6
272	R:R:H394	R:R:L341	2.57	Yes	No	0	9	6
273	R:R:Q364	R:R:Q372	2.56	No	No	0	5	5
274	R:R:I163	R:R:R92	2.51	No	No	0	6	1
275	R:R:F125	R:R:K126	2.48	No	No	0	6	6
276	R:R:F34	R:R:L75	2.44	No	Yes	0	7	9
277	R:R:L437	R:R:R443	2.43	No	No	0	7	9
278	R:R:K126	R:R:W129	2.32	No	No	0	6	6
279	R:R:L122	R:R:W129	2.28	No	No	0	7	6
280	R:R:F107	R:R:F111	2.14	No	Yes	0	8	8
281	R:R:F396	R:R:W416	2	No	No	0	4	7
282	R:R:C143	R:R:G144	1.96	No	No	0	8	5
283	R:R:G397	R:R:S400	1.86	No	No	0	8	2
284	R:R:G410	R:R:T403	1.82	No	No	0	3	2
285	R:R:G42	R:R:L69	1.71	No	No	0	6	7
286	R:R:G49	R:R:L50	1.71	No	No	0	7	4
287	R:R:G91	R:R:L94	1.71	No	Yes	0	9	8
288	R:R:G410	R:R:L409	1.71	No	No	0	3	3
289	R:R:A446	R:R:V47	1.7	No	Yes	0	8	8
290	R:R:A384	R:R:V380	1.7	No	No	0	5	3
291	R:R:I336	R:R:P156	1.69	No	No	0	7	9
292	R:R:D441	R:R:G439	1.68	No	No	0	7	9
293	R:R:K126	R:R:P127	1.67	No	No	0	6	9
294	R:R:G86	R:R:Q87	1.64	No	No	0	7	6
295	R:R:L437	R:R:P432	1.64	No	Yes	0	7	9
296	R:R:S449	R:R:V47	1.62	No	Yes	0	9	8
297	R:R:S349	R:R:V350	1.62	Yes	No	0	4	4
298	R:R:V148	R:R:V152	1.6	No	No	0	5	5
299	R:R:S371	R:R:T375	1.6	No	No	0	7	7
300	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
301	R:R:A83	R:R:L84	1.58	No	No	0	5	8
302	R:R:I353	R:R:V383	1.54	No	No	0	5	8
303	R:R:I395	R:R:V398	1.54	No	No	0	5	7
304	R:R:K374	R:R:S373	1.53	No	No	0	9	4
305	R:R:I336	R:R:T337	1.52	No	No	0	7	7
306	R:R:I338	R:R:T339	1.52	No	No	0	6	8
307	L:L:L73	L:L:S71	1.5	No	No	0	0	0
308	L:L:K72	R:R:T166	1.5	Yes	No	0	0	1
309	R:R:L346	R:R:S349	1.5	No	Yes	0	8	4
310	R:R:L32	R:R:V28	1.49	No	No	0	6	6
311	R:R:L423	R:R:V419	1.49	No	No	0	8	5
312	R:R:I101	R:R:L97	1.43	Yes	No	0	5	6
313	R:R:C154	R:R:F151	1.4	Yes	No	0	8	5
314	R:R:E162	R:R:K96	1.35	No	No	0	5	8
315	R:R:A80	R:R:Y90	1.33	No	Yes	0	5	7
316	R:R:E20	R:R:N19	1.31	Yes	No	0	4	1
317	R:R:V159	R:R:Y160	1.26	No	No	0	4	8
318	R:R:F164	R:R:K175	1.24	No	No	0	3	5
319	R:R:L84	R:R:R171	1.21	No	Yes	0	8	1
320	L:L:R69	L:L:Y68	1.03	Yes	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R69	5.995	4	0	0
2	L:L:K72	7.0825	4	7	0
3	L:L:R77	9.3425	4	3	0
4	R:R:E20	8.705	4	4	4
5	R:R:P22	5.1625	4	0	4
6	R:R:V23	7.4925	4	4	4
7	R:R:L30	5.732	5	5	6
8	R:R:T33	3.8175	4	5	8
9	R:R:N41	6.084	5	0	9
10	R:R:V44	5.12	4	8	9
11	R:R:V47	4.365	4	0	8
12	R:R:V56	4.9575	4	0	8
13	R:R:W60	4.76333	6	0	8
14	R:R:L64	4.52167	6	1	9
15	R:R:D68	7.238	5	1	9
16	R:R:L75	5.386	5	5	9
17	R:R:L82	4.9275	4	4	7
18	R:R:W88	7.64143	7	2	9
19	R:R:Y90	11.968	5	2	7
20	R:R:L94	5.2175	4	2	8
21	R:R:C95	6.0925	4	2	9
22	R:R:I98	6.954	5	2	8
23	R:R:I101	3.3525	4	2	5
24	R:R:I102	3.7125	4	2	8
25	R:R:M106	4.5575	4	3	9
26	R:R:S109	4.4575	4	1	9
27	R:R:F111	2.865	4	0	8
28	R:R:L113	7.6625	4	1	8
29	R:R:I116	4.61	4	1	9
30	R:R:S117	4.145	4	1	9
31	R:R:R134	8.5625	4	6	9
32	R:R:W147	5.91	4	0	9
33	R:R:C154	3.68	4	0	8
34	R:R:R161	7.684	5	2	8
35	R:R:R171	12.9575	4	7	1
36	R:R:P348	4.465	4	0	9
37	R:R:S349	2.1	4	0	4
38	R:R:Y356	5.345	6	1	9
39	R:R:V382	4.174	5	1	8
40	R:R:W390	7.07857	7	3	9
41	R:R:Y393	5.725	6	3	9
42	R:R:H394	8.3975	4	3	9
43	R:R:H418	4.6775	4	4	4
44	R:R:N431	7.97	5	1	9
45	R:R:P432	4.345	4	0	9
46	R:R:L434	5.11	4	1	9
47	R:R:Y435	6.02571	7	1	9
48	R:R:F442	7.205	6	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K72	R:R:R171	59.8652	11.14	Yes	Yes	7	0	1
2	R:R:H81	R:R:R171	72.0703	30.47	No	Yes	0	7	1
3	L:L:L75	R:R:H81	73.2803	12.86	No	No	0	0	7
4	L:L:L75	R:R:I102	75.8661	2.85	No	Yes	0	0	8
5	R:R:I101	R:R:I102	94.4693	2.94	Yes	Yes	2	5	8
6	R:R:I101	R:R:L70	97.37	2.85	Yes	No	0	5	6
7	R:R:L70	R:R:N105	99.127	5.49	No	No	0	6	9
8	R:R:C71	R:R:N105	100	11.02	No	No	0	8	9
9	R:R:C71	R:R:M106	32.6427	3.24	No	Yes	0	8	9
10	R:R:M106	R:R:Y393	15.0285	4.79	Yes	Yes	3	9	9
11	L:L:R77	R:R:Y393	35.1677	7.2	Yes	Yes	3	0	9
12	L:L:L73	L:L:R77	27.6535	10.93	No	Yes	0	0	0
13	L:L:L73	L:L:S71	24.808	1.5	No	No	0	0	0
14	L:L:S71	R:R:M414	21.6752	6.13	No	No	0	0	2
15	R:R:M414	R:R:P405	18.8132	6.71	No	No	0	2	4
16	L:L:R69	R:R:P405	15.6583	7.21	Yes	No	0	0	4
17	L:L:K72	R:R:Q85	52.2128	12.2	Yes	No	0	0	5
18	R:R:H418	R:R:Q85	15.139	4.95	Yes	No	0	4	5
19	R:R:Q85	R:R:W18	35.5876	13.14	No	No	0	5	1
20	R:R:E20	R:R:W18	32.278	21.81	Yes	No	4	4	1
21	R:R:E20	R:R:P22	29.8967	3.14	Yes	Yes	0	4	4
22	R:R:P22	R:R:W416	23.1118	8.11	Yes	No	0	4	7
23	R:R:H418	R:R:L82	10.2658	6.43	Yes	Yes	4	4	7
24	R:R:W390	R:R:Y393	41.4609	6.75	Yes	Yes	3	9	9
25	R:R:N427	R:R:W390	49.7486	12.43	No	Yes	0	9	9
26	R:R:N427	R:R:N431	51.9034	10.9	No	Yes	0	9	9
27	R:R:L64	R:R:N431	23.8356	5.49	Yes	Yes	1	9	9
28	R:R:L64	R:R:Y435	88.6403	3.52	Yes	Yes	1	9	9
29	R:R:L434	R:R:Y435	67.2579	7.03	Yes	Yes	1	9	9
30	R:R:L434	R:R:V385	42.1515	4.47	Yes	No	0	9	7
31	R:R:F430	R:R:V385	40.5934	5.24	No	No	0	7	7
32	R:R:C429	R:R:F430	37.1236	2.79	No	No	0	9	7
33	R:R:C429	R:R:T33	30.0514	3.38	No	Yes	0	9	8
34	R:R:L113	R:R:N431	23.0731	6.87	Yes	Yes	1	8	9
35	R:R:L113	R:R:Y435	24.0013	15.24	Yes	Yes	1	8	9
36	R:R:L75	R:R:T33	15.1113	2.95	Yes	Yes	5	9	8
37	R:R:C71	R:R:S428	82.5681	6.89	No	No	0	8	9
38	R:R:D68	R:R:S428	82.7725	5.89	Yes	No	0	9	9
39	R:R:D68	R:R:N41	36.1346	5.39	Yes	Yes	0	9	9
40	R:R:N41	R:R:P432	26.4214	8.15	Yes	Yes	0	9	9
41	R:R:P432	R:R:V44	21.0343	3.53	Yes	Yes	0	9	9
42	R:R:F442	R:R:V44	20.2111	3.93	Yes	Yes	8	9	9
43	R:R:F442	R:R:V47	13.4317	6.55	Yes	Yes	0	9	8
44	R:R:I116	R:R:Y435	75.634	3.63	Yes	Yes	1	9	9
45	R:R:F61	R:R:I116	32.4659	3.77	No	Yes	0	8	9
46	R:R:F442	R:R:F61	30.5984	10.72	Yes	No	0	9	8
47	R:R:A48	R:R:F442	13.5864	5.55	No	Yes	0	7	9
48	R:R:A48	R:R:L62	11.3487	3.15	No	No	0	7	8
49	R:R:D441	R:R:F442	13.4317	9.55	No	Yes	0	7	9
50	R:R:I116	R:R:W60	74.424	3.52	Yes	Yes	0	9	8
51	R:R:V56	R:R:W60	26.681	3.68	Yes	Yes	0	8	8
52	R:R:R134	R:R:V56	21.1006	7.85	Yes	Yes	0	9	8
53	R:R:D119	R:R:W60	43.7483	10.05	No	Yes	0	9	8
54	R:R:D119	R:R:R134	20.968	14.29	No	Yes	6	9	9
55	R:R:R340	R:R:Y393	27.5651	6.17	No	Yes	0	9	9
56	R:R:R340	R:R:V103	15.9401	5.23	No	No	0	9	5
57	R:R:C154	R:R:V103	15.4318	5.12	Yes	No	0	8	5
58	R:R:C154	R:R:L104	30.4105	4.76	Yes	No	0	8	8
59	R:R:L104	R:R:W147	30.4326	4.56	No	Yes	0	8	9
60	R:R:H63	R:R:W147	30.8636	7.41	No	Yes	0	8	9
61	R:R:C143	R:R:H63	31.6261	14.74	No	No	0	8	8
62	R:R:I102	R:R:I98	44.5881	4.42	Yes	Yes	2	8	8
63	R:R:I98	R:R:W88	26.4711	3.52	Yes	Yes	2	8	9
64	R:R:C154	R:R:S100	35.6594	3.44	Yes	No	0	8	8
65	R:R:S100	R:R:V157	34.7809	3.23	No	No	0	8	9
66	R:R:R161	R:R:V157	33.9024	3.92	Yes	No	0	8	9
67	R:R:C95	R:R:R161	11.0945	4.18	Yes	Yes	2	9	8
68	R:R:C95	R:R:W88	10.9896	9.14	Yes	Yes	2	9	9
69	R:R:C172	R:R:R161	11.1222	4.18	No	Yes	2	8	8
70	R:R:C172	R:R:W88	10.9343	7.84	No	Yes	2	8	9
71	R:R:I163	R:R:W88	35.0572	3.52	No	Yes	0	6	9
72	R:R:I163	R:R:R92	30.4602	2.51	No	No	0	6	1
73	R:R:K96	R:R:R92	28.1452	3.71	No	No	0	8	1
74	R:R:F158	R:R:K96	23.482	11.17	No	No	0	8	8
75	R:R:F107	R:R:R340	17.2827	12.83	No	No	0	8	9
76	R:R:V110	R:R:W390	13.5367	6.13	No	Yes	0	9	9
77	R:R:P348	R:R:V110	10.9675	3.53	Yes	No	0	9	9
78	R:R:F107	R:R:F111	14.4428	2.14	No	Yes	0	8	8
79	R:R:F386	R:R:W390	13.7853	7.02	No	Yes	0	9	9
80	R:R:F386	R:R:L387	13.0781	6.09	No	No	0	9	6
81	R:R:L387	R:R:V383	14.5864	2.98	No	No	0	6	8
82	R:R:V383	R:R:Y356	15.3876	3.79	No	Yes	0	8	9
83	R:R:R120	R:R:Y356	12.8239	8.23	No	Yes	1	9	9
84	R:R:I351	R:R:L118	12.2824	4.28	No	No	0	6	8
85	R:R:S117	R:R:Y356	11.6747	3.82	Yes	Yes	1	9	9
86	R:R:M352	R:R:Y435	15.5368	3.59	No	Yes	1	8	9
87	R:R:C355	R:R:S117	11.5144	5.16	No	Yes	1	9	9
88	R:R:D119	R:R:V123	21.2056	5.84	No	No	6	9	5
89	R:R:C121	R:R:C355	11.1774	7.28	No	No	0	9	9
90	R:R:C130	R:R:R134	38.7259	5.57	No	Yes	6	7	9
91	R:R:C130	R:R:V123	19.3326	3.42	No	No	6	7	5
92	R:R:C130	R:R:L122	52.3068	4.76	No	No	0	7	7
93	R:R:L122	R:R:W129	46.5385	2.28	No	No	0	7	6
94	R:R:K126	R:R:W129	23.3549	2.32	No	No	0	6	6
95	R:R:K126	R:R:P127	11.6968	1.67	No	No	0	6	9
96	R:R:H133	R:R:W129	17.5314	20.1	No	No	0	8	6
97	R:R:H133	R:R:N132	11.6968	3.83	No	No	0	8	8
98	R:R:F158	R:R:I155	21.1338	5.02	No	No	0	8	5
99	R:R:I155	R:R:P156	18.7745	5.08	No	No	0	5	9
100	R:R:I336	R:R:P156	16.3987	1.69	No	No	0	7	9
101	R:R:I336	R:R:T337	14.2494	1.52	No	No	0	7	7
102	R:R:L401	R:R:T337	11.857	4.42	No	No	0	7	7
103	R:R:V382	R:R:Y356	12.6416	5.05	Yes	Yes	1	8	9
104	R:R:V382	R:R:Y435	35.8528	5.05	Yes	Yes	1	8	9
105	R:R:V381	R:R:V382	37.3446	3.21	No	Yes	1	7	8
106	R:R:R377	R:R:V381	67.059	6.54	No	No	0	5	7
107	R:R:R377	R:R:V380	63.766	5.23	No	No	0	5	3
108	R:R:F376	R:R:V380	57.1468	9.18	No	No	0	4	3
109	R:R:F376	R:R:V360	53.8151	2.62	No	No	0	4	6
110	R:R:M363	R:R:V360	50.9089	9.13	No	No	0	7	6
111	R:R:L434	R:R:V381	32.7808	2.98	Yes	No	1	9	7
112	R:R:M363	R:R:Q372	27.2446	12.23	No	No	0	7	5
113	R:R:Q364	R:R:Q372	23.8135	2.56	No	No	0	5	5
114	R:R:Q364	R:R:R365	16.9291	5.84	No	No	0	5	4
115	R:R:R362	R:R:R365	10.0006	11.73	No	No	0	7	4
116	R:R:M363	R:R:T375	20.8409	13.55	No	No	0	7	7
117	R:R:S371	R:R:T375	17.3988	1.6	No	No	0	7	7
118	R:R:F396	R:R:W416	19.642	2	No	No	0	4	7
119	R:R:F396	R:R:L413	16.2937	8.53	No	No	0	4	7
120	R:R:D68	R:R:L64	67.5286	5.43	Yes	Yes	1	9	9
121	R:R:M106	R:R:W390	18.4817	6.98	Yes	Yes	3	9	9
122	R:R:M352	R:R:S117	12.4316	4.6	No	Yes	1	8	9
123	R:R:L118	R:R:S117	10.3763	3	No	Yes	1	8	9
124	R:R:C143	R:R:W60	32.6316	3.92	No	Yes	0	8	8
125	R:R:I116	R:R:R120	11.4426	7.52	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R69	R:R:D404	13.1	0	Yes	No	0	4	0	1
L:L:R69	R:R:P405	7.21	0	Yes	No	0	4	0	1
L:L:A70	R:R:K175	8.03	0	No	No	0	5	0	1
L:L:S71	R:R:M414	6.13	0	No	No	0	2	0	1
L:L:K72	R:R:Q85	12.2	7	Yes	No	0	5	0	1
L:L:K72	R:R:G86	3.49	7	Yes	No	0	7	0	1
L:L:K72	R:R:R171	11.14	7	Yes	Yes	0	1	0	1
L:L:G74	R:R:H418	3.18	0	No	Yes	0	4	0	1
L:L:L75	R:R:S78	6.01	0	No	No	0	8	0	1
L:L:L75	R:R:H81	12.86	0	No	No	0	7	0	1
L:L:L75	R:R:I102	2.85	0	No	Yes	0	8	0	1
L:L:A76	R:R:M106	3.22	0	No	Yes	0	9	0	1
L:L:A76	R:R:I421	3.25	0	No	No	0	4	0	1
L:L:R77	R:R:Y393	7.2	3	Yes	Yes	0	9	0	1
L:L:R77	R:R:D417	15.48	3	Yes	No	0	8	0	1
L:L:R77	R:R:I421	3.76	3	Yes	No	0	4	0	1
R:R:V23	R:R:W18	9.81	4	Yes	No	4	1	2	2
R:R:Q85	R:R:W18	13.14	0	No	No	5	1	1	2
R:R:L82	R:R:V23	7.45	4	Yes	Yes	7	4	2	2
R:R:H418	R:R:V23	4.15	4	Yes	Yes	4	4	1	2
R:R:C71	R:R:M106	3.24	0	No	Yes	8	9	2	1
R:R:I101	R:R:S74	6.19	2	Yes	No	5	9	2	2
R:R:I102	R:R:S74	4.64	2	Yes	No	8	9	1	2
R:R:H81	R:R:R171	30.47	0	No	Yes	7	1	1	1
R:R:H418	R:R:L82	6.43	4	Yes	Yes	4	7	1	2
R:R:H418	R:R:Q85	4.95	4	Yes	No	4	5	1	1
R:R:G86	R:R:R171	9.01	7	No	Yes	7	1	1	1
R:R:I102	R:R:I98	4.42	2	Yes	Yes	8	8	1	2
R:R:I101	R:R:I102	2.94	2	Yes	Yes	5	8	2	1
R:R:M106	R:R:W390	6.98	3	Yes	Yes	9	9	1	2
R:R:M106	R:R:Y393	4.79	3	Yes	Yes	9	9	1	1
R:R:F164	R:R:T166	9.08	0	No	No	3	1	2	1
R:R:R340	R:R:Y393	6.17	0	No	Yes	9	9	2	1
R:R:W390	R:R:Y393	6.75	3	Yes	Yes	9	9	2	1
R:R:H394	R:R:W390	6.35	3	Yes	Yes	9	9	2	2
R:R:A424	R:R:W390	3.89	3	No	Yes	9	9	2	2
R:R:H394	R:R:Y393	5.44	3	Yes	Yes	9	9	2	1
R:R:A424	R:R:Y393	4	3	No	Yes	9	9	2	1
R:R:M414	R:R:P405	6.71	0	No	No	2	4	1	1
R:R:D417	R:R:I421	7	3	No	No	8	4	1	1
L:L:R69	R:R:S400	2.64	0	Yes	No	0	2	0	1
R:R:G397	R:R:S400	1.86	0	No	No	8	2	2	1
R:R:G86	R:R:Q87	1.64	7	No	No	7	6	1	2
L:L:K72	R:R:T166	1.5	7	Yes	No	0	1	0	1
R:R:F164	R:R:K175	1.24	0	No	No	3	5	2	1
R:R:L84	R:R:R171	1.21	0	No	Yes	8	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J6D_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	273
Number of Links	320
Number of Hubs	48
Number of Links mediated by Hubs	171
Number of Communities	10
Number of Nodes involved in Communities	61
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	126
Number Of Links MetaPath	125
Number of Shortest Paths	60752
Length Of Smallest Path	3
Average Path Length	14.8403
Length of Longest Path	36
Minimum Path Strength	1.395
Average Path Strength	6.35224
Maximum Path Strength	19.74
Minimum Path Correlation	0.7
Average Path Correlation	0.91969
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	42.712
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1908
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • complement component C3a receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • G protein-coupled receptor activity • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • calcium-mediated signaling • circulatory system process • blood circulation • intracellular vesicle • endomembrane system • specific granule membrane • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule • azurophil granule • primary lysosome • azurophil granule membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8J6D_nogp_Chain_R W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y K T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

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