psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A9	R:R:F164	8.32	No	No	0	0	3
2	L:L:L12	L:L:S10	3	No	No	0	0	0
3	L:L:S10	R:R:G173	3.71	No	No	0	0	1
4	L:L:K11	R:R:G86	5.23	No	No	5	0	7
5	L:L:K11	R:R:R171	6.19	No	No	5	0	1
6	L:L:L12	L:L:R16	7.29	No	Yes	0	0	0
7	L:L:L14	R:R:I98	2.85	Yes	Yes	2	0	8
8	L:L:L14	R:R:P99	4.93	Yes	Yes	2	0	8
9	L:L:L14	R:R:I102	2.85	Yes	No	0	0	8
10	L:L:A15	R:R:M106	3.22	No	No	0	0	9
11	L:L:R16	R:R:Y393	20.58	Yes	Yes	1	0	9
12	L:L:R16	R:R:G397	3	Yes	No	0	0	8
13	L:L:R16	R:R:D417	13.1	Yes	No	1	0	8
14	L:L:R16	R:R:I421	7.52	Yes	No	1	0	4
15	R:R:N19	R:R:W18	15.82	No	No	0	1	1
16	R:R:E20	R:R:V23	8.56	No	Yes	0	4	4
17	R:R:P21	R:R:P22	5.84	No	No	0	6	4
18	R:R:P22	R:R:S415	5.34	No	No	6	4	5
19	R:R:P22	R:R:W416	22.97	No	No	6	4	7
20	R:R:S26	R:R:V23	3.23	No	Yes	4	8	4
21	R:R:M27	R:R:V23	3.04	Yes	Yes	4	6	4
22	R:R:L82	R:R:V23	4.47	Yes	Yes	4	7	4
23	R:R:I29	R:R:L25	7.14	No	No	0	7	5
24	R:R:M27	R:R:S26	4.6	Yes	No	4	6	8
25	R:R:L82	R:R:S26	4.5	Yes	No	4	7	8
26	R:R:L79	R:R:M27	2.83	Yes	Yes	0	6	6
27	R:R:L82	R:R:M27	2.83	Yes	Yes	4	7	6
28	R:R:A422	R:R:I29	3.25	No	No	0	8	7
29	R:R:L30	R:R:L75	9.69	No	No	0	6	9
30	R:R:L30	R:R:L79	4.15	No	Yes	0	6	6
31	R:R:L79	R:R:S31	3	Yes	No	0	6	7
32	R:R:F34	R:R:L38	14.61	No	No	0	7	7
33	R:R:F34	R:R:P76	4.33	No	No	0	7	9
34	R:R:F433	R:R:L36	3.65	No	No	0	6	8
35	R:R:L38	R:R:L73	2.77	No	No	0	7	8
36	R:R:D68	R:R:N41	6.73	Yes	Yes	0	9	9
37	R:R:L69	R:R:N41	2.75	No	Yes	0	7	9
38	R:R:C72	R:R:N41	4.72	No	Yes	0	8	9
39	R:R:N41	R:R:P432	8.15	Yes	No	0	9	9
40	R:R:L43	R:R:V47	2.98	No	No	0	8	8
41	R:R:T65	R:R:V44	6.35	No	Yes	0	9	9
42	R:R:A436	R:R:V44	3.39	No	Yes	7	8	9
43	R:R:F442	R:R:V44	5.24	Yes	Yes	7	9	9
44	R:R:L45	R:R:T65	2.95	No	No	0	8	9
45	R:R:L50	R:R:W46	5.69	No	No	0	4	6
46	R:R:S449	R:R:W46	6.18	No	No	0	9	6
47	R:R:F442	R:R:V47	10.49	Yes	No	0	9	8
48	R:R:A48	R:R:F442	2.77	No	Yes	0	7	9
49	R:R:F442	R:R:M52	4.98	Yes	No	0	9	9
50	R:R:R54	R:R:T58	5.17	No	No	0	7	8
51	R:R:L62	R:R:R54	3.64	No	No	0	8	7
52	R:R:T55	R:R:T58	6.28	No	No	0	9	8
53	R:R:V56	R:R:W60	3.68	No	Yes	0	8	8
54	R:R:R134	R:R:V56	9.15	Yes	No	0	9	8
55	R:R:I59	R:R:T58	3.04	Yes	No	0	6	8
56	R:R:H63	R:R:I59	2.65	Yes	Yes	0	8	6
57	R:R:I59	R:R:V136	3.07	Yes	No	0	6	7
58	R:R:A139	R:R:I59	4.87	No	Yes	0	7	6
59	R:R:C140	R:R:I59	4.91	No	Yes	0	4	6
60	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
61	R:R:I116	R:R:W60	3.52	No	Yes	0	9	8
62	R:R:D119	R:R:W60	7.82	No	Yes	0	9	8
63	R:R:I142	R:R:W60	3.52	No	Yes	0	5	8
64	R:R:C143	R:R:W60	5.22	No	Yes	0	8	8
65	R:R:H63	R:R:L112	2.57	Yes	No	0	8	9
66	R:R:C143	R:R:H63	14.74	No	Yes	0	8	8
67	R:R:H63	R:R:W147	7.41	Yes	Yes	0	8	9
68	R:R:D68	R:R:L64	4.07	Yes	No	0	9	9
69	R:R:L113	R:R:L64	4.15	No	No	0	8	9
70	R:R:L66	R:R:L70	2.77	No	No	0	4	6
71	R:R:A67	R:R:W147	3.89	No	Yes	0	9	9
72	R:R:D68	R:R:S109	5.89	Yes	No	0	9	9
73	R:R:D68	R:R:S428	8.83	Yes	No	0	9	9
74	R:R:D68	R:R:N431	10.77	Yes	No	0	9	9
75	R:R:L69	R:R:L73	6.92	No	No	0	7	8
76	R:R:L70	R:R:N105	6.87	No	No	0	6	9
77	R:R:C71	R:R:S428	3.44	No	No	0	8	9
78	R:R:F77	R:R:S74	2.64	No	No	0	8	9
79	R:R:I102	R:R:S74	4.64	No	No	0	8	9
80	R:R:L75	R:R:S425	3	No	No	0	9	8
81	R:R:F77	R:R:Y90	4.13	No	Yes	0	8	7
82	R:R:F77	R:R:I98	2.51	No	Yes	0	8	8
83	R:R:A80	R:R:Y90	2.67	No	Yes	0	5	7
84	R:R:G86	R:R:H81	3.18	No	No	0	7	7
85	R:R:H418	R:R:L82	3.86	No	Yes	0	4	7
86	R:R:L84	R:R:Q87	2.66	No	Yes	9	8	6
87	R:R:L84	R:R:P89	3.28	No	No	9	8	8
88	R:R:G86	R:R:R171	3	No	No	5	7	1
89	R:R:P89	R:R:Q87	14.21	No	Yes	9	8	6
90	R:R:H169	R:R:Q87	9.89	No	Yes	0	3	6
91	R:R:N170	R:R:Q87	3.96	No	Yes	0	4	6
92	R:R:W88	R:R:Y90	5.79	Yes	Yes	0	9	7
93	R:R:C95	R:R:W88	5.22	No	Yes	2	9	9
94	R:R:I98	R:R:W88	4.7	Yes	Yes	2	8	9
95	R:R:I163	R:R:W88	3.52	Yes	Yes	2	6	9
96	R:R:P89	R:R:Y90	2.78	No	Yes	0	8	7
97	R:R:G91	R:R:R92	3	No	No	0	9	1
98	R:R:I163	R:R:R92	2.51	Yes	No	0	6	1
99	R:R:F93	R:R:K96	3.72	No	No	0	4	8
100	R:R:C95	R:R:I163	3.27	No	Yes	2	9	6
101	R:R:C172	R:R:C95	7.28	No	No	0	8	9
102	R:R:I101	R:R:L97	2.85	No	No	0	5	6
103	R:R:F158	R:R:L97	4.87	No	No	0	8	6
104	R:R:I98	R:R:P99	3.39	Yes	Yes	2	8	8
105	R:R:P99	R:R:V157	3.53	Yes	No	0	8	9
106	R:R:P99	R:R:R161	11.53	Yes	No	0	8	8
107	R:R:C154	R:R:S100	3.44	No	No	0	8	8
108	R:R:F107	R:R:V103	2.62	No	No	1	8	5
109	R:R:C154	R:R:V103	3.42	No	No	0	8	5
110	R:R:R340	R:R:V103	5.23	Yes	No	1	9	5
111	R:R:C154	R:R:L104	4.76	No	No	0	8	8
112	R:R:M106	R:R:W390	5.82	No	Yes	0	9	9
113	R:R:F107	R:R:M153	3.73	No	No	0	8	8
114	R:R:F107	R:R:R340	8.55	No	Yes	1	8	9
115	R:R:A108	R:R:W147	3.89	No	Yes	0	9	9
116	R:R:P348	R:R:V110	3.53	Yes	No	1	9	9
117	R:R:F386	R:R:V110	2.62	Yes	No	1	9	9
118	R:R:V110	R:R:W390	4.9	No	Yes	1	9	9
119	R:R:F111	R:R:I146	2.51	Yes	No	0	8	8
120	R:R:F111	R:R:V149	2.62	Yes	No	0	8	4
121	R:R:F111	R:R:V343	2.62	Yes	No	0	8	4
122	R:R:F111	R:R:G344	3.01	Yes	No	1	8	9
123	R:R:F111	R:R:P348	2.89	Yes	Yes	1	8	9
124	R:R:I146	R:R:L112	4.28	No	No	0	8	9
125	R:R:L113	R:R:N431	4.12	No	No	0	8	9
126	R:R:L113	R:R:Y435	7.03	No	Yes	0	8	9
127	R:R:P348	R:R:T114	3.5	Yes	No	0	9	8
128	R:R:I351	R:R:T114	4.56	No	No	0	6	8
129	R:R:I116	R:R:R120	3.76	No	No	8	9	9
130	R:R:I116	R:R:Y435	4.84	No	Yes	8	9	9
131	R:R:M352	R:R:S117	4.6	No	No	0	8	9
132	R:R:S117	R:R:Y356	6.36	No	Yes	0	9	9
133	R:R:I351	R:R:L118	4.28	No	No	0	6	8
134	R:R:C355	R:R:L118	3.17	No	No	0	9	8
135	R:R:D119	R:R:R134	11.91	No	Yes	0	9	9
136	R:R:R120	R:R:Y356	9.26	No	Yes	0	9	9
137	R:R:R120	R:R:Y435	6.17	No	Yes	8	9	9
138	R:R:C121	R:R:C355	5.46	No	No	0	9	9
139	R:R:C121	R:R:F358	4.19	No	Yes	0	9	6
140	R:R:K126	R:R:L122	2.82	No	No	0	6	7
141	R:R:C130	R:R:L122	4.76	No	No	0	7	7
142	R:R:R134	R:R:V123	5.23	Yes	No	0	9	5
143	R:R:F358	R:R:V124	2.62	Yes	No	10	6	9
144	R:R:R362	R:R:V124	3.92	No	No	10	7	9
145	R:R:F125	R:R:K126	6.2	No	No	0	6	6
146	R:R:F125	R:R:F358	7.5	No	Yes	0	6	6
147	R:R:C130	R:R:W129	2.61	No	No	0	7	6
148	R:R:H133	R:R:W129	19.04	No	No	0	8	6
149	R:R:C130	R:R:R134	4.18	No	Yes	0	7	9
150	R:R:H133	R:R:N132	6.38	No	No	0	8	8
151	R:R:M138	R:R:R134	6.2	No	Yes	0	6	9
152	R:R:I142	R:R:M138	2.92	No	No	0	5	6
153	R:R:F151	R:R:I155	2.51	No	No	0	5	5
154	R:R:I155	R:R:P156	3.39	No	No	0	5	9
155	R:R:I336	R:R:P156	3.39	No	No	0	7	9
156	R:R:V157	R:R:Y174	2.52	No	No	0	9	7
157	R:R:V159	R:R:Y160	7.57	No	No	0	4	8
158	R:R:F176	R:R:Y160	9.28	Yes	No	3	4	8
159	R:R:P332	R:R:Y160	6.95	No	No	3	4	8
160	R:R:C172	R:R:R161	6.96	No	No	0	8	8
161	R:R:R161	R:R:Y174	18.52	No	No	0	8	7
162	R:R:E162	R:R:F164	11.66	No	No	0	5	3
163	R:R:E162	R:R:K175	10.8	No	No	0	5	5
164	R:R:I163	R:R:N170	7.08	Yes	No	0	6	4
165	R:R:F164	R:R:G173	3.01	No	No	0	3	1
166	R:R:D167	R:R:T166	5.78	No	No	0	3	1
167	R:R:H169	R:R:R171	5.64	No	No	0	3	1
168	R:R:F176	R:R:Y174	14.44	Yes	No	0	4	7
169	R:R:F176	R:R:P330	7.22	Yes	No	3	4	2
170	R:R:F176	R:R:P332	8.67	Yes	No	3	4	4
171	R:R:F176	R:R:L333	15.83	Yes	No	3	4	3
172	R:R:F176	R:R:I336	2.51	Yes	No	0	4	7
173	R:R:P330	R:R:V329	3.53	No	No	0	2	3
174	R:R:L333	R:R:P330	6.57	No	No	3	3	2
175	R:R:P332	R:R:T331	3.5	No	No	0	4	4
176	R:R:L333	R:R:L401	2.77	No	No	0	3	7
177	R:R:L401	R:R:V334	2.98	No	No	0	7	4
178	R:R:I336	R:R:R340	3.76	No	Yes	0	7	9
179	R:R:L401	R:R:T337	4.42	No	No	0	7	7
180	R:R:R340	R:R:Y393	5.14	Yes	Yes	1	9	9
181	R:R:L341	R:R:L346	2.77	No	No	0	6	8
182	R:R:H394	R:R:L341	2.57	No	No	0	9	6
183	R:R:G344	R:R:P348	4.06	No	Yes	1	9	9
184	R:R:F345	R:R:T391	5.19	No	Yes	0	9	6
185	R:R:F345	R:R:H394	19.23	No	No	0	9	9
186	R:R:M352	R:R:V383	3.04	No	No	0	8	8
187	R:R:F386	R:R:M352	4.98	Yes	No	0	9	8
188	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
189	R:R:V382	R:R:Y356	3.79	Yes	Yes	0	8	9
190	R:R:V383	R:R:Y356	5.05	No	Yes	0	8	9
191	R:R:F358	R:R:R362	12.83	Yes	No	10	6	7
192	R:R:Q364	R:R:V360	4.3	No	Yes	0	5	6
193	R:R:F376	R:R:V360	2.62	No	Yes	0	4	6
194	R:R:F361	R:R:R365	10.69	No	No	0	4	4
195	R:R:F368	R:R:R367	14.97	No	No	0	5	6
196	R:R:K370	R:R:Q372	4.07	No	No	0	7	5
197	R:R:Q372	R:R:T375	4.25	No	No	0	5	7
198	R:R:R377	R:R:S373	3.95	No	No	0	5	4
199	R:R:K374	R:R:V378	3.04	No	No	0	9	8
200	R:R:F376	R:R:V380	5.24	No	No	0	4	3
201	R:R:V382	R:R:Y435	3.79	Yes	Yes	0	8	9
202	R:R:F430	R:R:V385	3.93	No	No	0	7	7
203	R:R:L434	R:R:V385	4.47	No	No	0	9	7
204	R:R:F386	R:R:L387	3.65	Yes	Yes	0	9	6
205	R:R:F386	R:R:W390	7.02	Yes	Yes	1	9	9
206	R:R:L387	R:R:T391	2.95	Yes	Yes	0	6	6
207	R:R:C389	R:R:N427	7.87	No	No	0	9	9
208	R:R:C389	R:R:F430	2.79	No	No	0	9	7
209	R:R:W390	R:R:Y393	6.75	Yes	Yes	1	9	9
210	R:R:A424	R:R:W390	7.78	No	Yes	1	9	9
211	R:R:N427	R:R:W390	5.65	No	Yes	0	9	9
212	R:R:P392	R:R:T391	3.5	No	Yes	0	9	6
213	R:R:I395	R:R:T391	3.04	No	Yes	0	5	6
214	R:R:L423	R:R:P392	3.28	No	No	0	8	9
215	R:R:H394	R:R:Y393	6.53	No	Yes	0	9	9
216	R:R:A424	R:R:Y393	2.67	No	Yes	1	9	9
217	R:R:F396	R:R:L413	7.31	No	Yes	0	4	7
218	R:R:C420	R:R:F396	8.38	No	No	0	6	4
219	R:R:L399	R:R:L413	2.77	No	Yes	0	9	7
220	R:R:M414	R:R:S400	4.6	No	No	0	2	2
221	R:R:L413	R:R:T403	4.42	Yes	No	0	7	2
222	R:R:D404	R:R:P405	8.05	No	No	11	4	4
223	R:R:D404	R:R:E406	9.09	No	No	11	4	1
224	R:R:D404	R:R:T407	4.34	No	No	0	4	7
225	R:R:E406	R:R:P405	6.29	No	No	11	1	4
226	R:R:P408	R:R:T407	3.5	No	No	0	4	7
227	R:R:K411	R:R:P408	5.02	No	No	0	2	4
228	R:R:G410	R:R:L409	3.42	No	No	0	3	3
229	R:R:L409	R:R:L413	2.77	No	Yes	0	3	7
230	R:R:S415	R:R:W416	3.71	No	No	6	5	7
231	R:R:D417	R:R:I421	2.8	No	No	1	8	4
232	R:R:N427	R:R:N431	6.81	No	No	0	9	9
233	R:R:C429	R:R:F430	8.38	No	No	0	9	7
234	R:R:A436	R:R:F442	2.77	No	Yes	7	8	9
235	R:R:F442	R:R:L437	7.31	Yes	No	0	9	7
236	R:R:K444	R:R:Q448	5.42	No	No	0	5	7
237	R:R:K445	R:R:Q448	2.71	No	No	0	7	7
238	R:R:I450	R:R:L454	2.85	No	No	0	4	8
239	R:R:F158	R:R:K96	2.48	No	No	0	8	8
240	R:R:M363	R:R:R362	2.48	No	No	0	7	7
241	R:R:K374	R:R:R377	2.48	No	No	0	9	5
242	R:R:V419	R:R:W416	2.45	No	No	0	5	7
243	R:R:L66	R:R:W147	2.28	No	Yes	0	4	9
244	R:R:F61	R:R:Y435	2.06	No	Yes	0	8	9
245	R:R:G37	R:R:P39	2.03	No	No	0	9	7
246	R:R:G40	R:R:P39	2.03	No	No	0	9	7
247	R:R:G40	R:R:P432	2.03	No	No	0	9	9
248	R:R:A48	R:R:G49	1.95	No	No	0	7	7
249	R:R:C420	R:R:P392	1.88	No	No	0	6	9
250	R:R:A108	R:R:A150	1.79	No	No	0	9	9
251	R:R:P432	R:R:V44	1.77	No	Yes	0	9	9
252	L:L:G13	L:L:L12	1.71	No	No	0	0	0
253	R:R:G49	R:R:L50	1.71	No	No	0	7	4
254	R:R:G137	R:R:N135	1.7	No	No	0	5	5
255	R:R:A379	R:R:V360	1.7	No	Yes	0	7	6
256	R:R:I24	R:R:P21	1.69	No	No	0	7	6
257	R:R:C429	R:R:T33	1.69	No	No	0	9	8
258	R:R:I128	R:R:P127	1.69	No	No	0	7	9
259	R:R:A426	R:R:T33	1.68	No	No	0	8	8
260	R:R:K126	R:R:P127	1.67	No	No	0	6	9
261	R:R:L75	R:R:P76	1.64	No	No	0	9	9
262	R:R:L79	R:R:P76	1.64	Yes	No	0	6	9
263	R:R:C121	R:R:I359	1.64	No	No	0	9	9
264	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
265	R:R:G452	R:R:Q451	1.64	No	No	0	6	6
266	R:R:S349	R:R:V350	1.62	No	No	0	4	4
267	R:R:V342	R:R:V343	1.6	No	No	0	6	4
268	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
269	R:R:V381	R:R:V382	1.6	No	Yes	0	7	8
270	R:R:C429	R:R:L36	1.59	No	No	0	9	8
271	R:R:T337	R:R:V398	1.59	No	No	0	7	7
272	R:R:T375	R:R:V360	1.59	No	Yes	0	7	6
273	R:R:A83	R:R:L84	1.58	No	No	0	5	8
274	R:R:A446	R:R:L437	1.58	No	No	0	8	7
275	R:R:E20	R:R:P21	1.57	No	No	0	4	6
276	R:R:I353	R:R:S357	1.55	No	No	0	5	6
277	R:R:I29	R:R:V419	1.54	No	No	0	7	5
278	R:R:I338	R:R:V334	1.54	No	No	0	6	4
279	R:R:I338	R:R:V342	1.54	No	No	0	6	6
280	R:R:K445	R:R:V47	1.52	No	No	0	7	8
281	L:L:L14	R:R:S78	1.5	Yes	No	0	0	8
282	R:R:L30	R:R:S78	1.5	No	No	0	6	8
283	R:R:L387	R:R:S349	1.5	Yes	No	0	6	4
284	R:R:L25	R:R:V28	1.49	No	No	0	5	6
285	R:R:L32	R:R:V28	1.49	No	No	0	6	6
286	R:R:L438	R:R:V378	1.49	No	No	0	7	8
287	R:R:L402	R:R:V398	1.49	No	No	0	5	7
288	R:R:D417	R:R:S400	1.47	No	No	0	8	2
289	R:R:L409	R:R:T407	1.47	No	No	0	3	7
290	R:R:N57	R:R:T55	1.46	No	No	0	8	9
291	R:R:K445	R:R:K51	1.44	No	No	0	7	9
292	R:R:I353	R:R:L387	1.43	No	Yes	0	5	6
293	R:R:I101	R:R:N105	1.42	No	No	0	5	9
294	R:R:M138	R:R:N135	1.4	No	No	0	6	5
295	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
296	R:R:F93	R:R:L94	1.22	No	No	0	4	8
297	R:R:L437	R:R:R443	1.21	No	No	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L14	3.0325	4	2	0
2	L:L:R16	10.298	5	1	0
3	R:R:V23	4.825	4	4	4
4	R:R:M27	3.325	4	4	6
5	R:R:N41	5.5875	4	0	9
6	R:R:V44	4.1875	4	7	9
7	R:R:I59	3.708	5	0	6
8	R:R:W60	4.60833	6	0	8
9	R:R:H63	6.8425	4	0	8
10	R:R:D68	7.258	5	0	9
11	R:R:L79	2.905	4	0	6
12	R:R:L82	3.915	4	4	7
13	R:R:Q87	7.68	4	9	6
14	R:R:W88	4.8075	4	2	9
15	R:R:Y90	3.8425	4	0	7
16	R:R:I98	3.3625	4	2	8
17	R:R:P99	5.845	4	2	8
18	R:R:F111	2.73	5	1	8
19	R:R:R134	7.334	5	0	9
20	R:R:W147	4.3675	4	0	9
21	R:R:I163	4.095	4	2	6
22	R:R:F176	9.65833	6	3	4
23	R:R:R340	5.67	4	1	9
24	R:R:P348	3.124	5	1	9
25	R:R:Y356	5.692	5	0	9
26	R:R:F358	6.785	4	10	6
27	R:R:V360	2.5525	4	0	6
28	R:R:V382	2.695	4	0	8
29	R:R:F386	4.5675	4	1	9
30	R:R:L387	2.3825	4	0	6
31	R:R:W390	6.32	6	1	9
32	R:R:T391	3.67	4	0	6
33	R:R:Y393	8.334	5	1	9
34	R:R:L413	4.3175	4	0	7
35	R:R:Y435	4.778	5	8	9
36	R:R:F442	5.59333	6	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L12	L:L:S10	11.7158	3	No	No	0	0	0
2	L:L:L12	L:L:R16	15.1819	7.29	No	Yes	0	0	0
3	L:L:R16	R:R:Y393	25.9696	20.58	Yes	Yes	1	0	9
4	R:R:R340	R:R:Y393	99.0261	5.14	Yes	Yes	1	9	9
5	R:R:I336	R:R:R340	95.5371	3.76	No	Yes	0	7	9
6	R:R:F176	R:R:I336	93.4345	2.51	Yes	No	0	4	7
7	R:R:F176	R:R:Y174	100	14.44	Yes	No	0	4	7
8	R:R:R161	R:R:Y174	63.4317	18.52	No	No	0	8	7
9	R:R:C172	R:R:R161	28.0435	6.96	No	No	0	8	8
10	R:R:C172	R:R:C95	26.4222	7.28	No	No	0	8	9
11	R:R:C95	R:R:I163	16.6313	3.27	No	Yes	2	9	6
12	R:R:I163	R:R:N170	16.2933	7.08	Yes	No	0	6	4
13	R:R:N170	R:R:Q87	14.4085	3.96	No	Yes	0	4	6
14	R:R:H169	R:R:Q87	15.0043	9.89	No	Yes	0	3	6
15	R:R:H169	R:R:R171	12.0252	5.64	No	No	0	3	1
16	R:R:V157	R:R:Y174	35.7491	2.52	No	No	0	9	7
17	R:R:P99	R:R:V157	34.6376	3.53	Yes	No	0	8	9
18	L:L:L14	R:R:P99	29.3383	4.93	Yes	Yes	2	0	8
19	R:R:P99	R:R:R161	34.735	11.53	Yes	No	0	8	8
20	R:R:I98	R:R:P99	38.2355	3.39	Yes	Yes	2	8	8
21	R:R:W390	R:R:Y393	90.5127	6.75	Yes	Yes	1	9	9
22	L:L:L14	R:R:S78	41.1	1.5	Yes	No	0	0	8
23	R:R:L30	R:R:S78	40.3609	1.5	No	No	0	6	8
24	R:R:L30	R:R:L79	29.5331	4.15	No	Yes	0	6	6
25	R:R:L79	R:R:M27	44.6004	2.83	Yes	Yes	0	6	6
26	R:R:M27	R:R:V23	34.1793	3.04	Yes	Yes	4	6	4
27	R:R:E20	R:R:V23	31.8247	8.56	No	Yes	0	4	4
28	R:R:E20	R:R:P21	29.2352	1.57	No	No	0	4	6
29	R:R:P21	R:R:P22	24.0218	5.84	No	No	0	6	4
30	R:R:P22	R:R:W416	18.7224	22.97	No	No	6	4	7
31	R:R:V419	R:R:W416	16.1157	2.45	No	No	0	5	7
32	R:R:I29	R:R:V419	13.4575	1.54	No	No	0	7	5
33	R:R:L30	R:R:L75	12.4893	9.69	No	No	0	6	9
34	R:R:N427	R:R:W390	62.0968	5.65	No	Yes	0	9	9
35	R:R:N427	R:R:N431	59.0604	6.81	No	No	0	9	9
36	R:R:D68	R:R:N431	61.375	10.77	Yes	No	0	9	9
37	R:R:D68	R:R:N41	85.815	6.73	Yes	Yes	0	9	9
38	R:R:L69	R:R:N41	58.0865	2.75	No	Yes	0	7	9
39	R:R:L69	R:R:L73	56.9121	6.92	No	No	0	7	8
40	R:R:L38	R:R:L73	55.7548	2.77	No	No	0	7	8
41	R:R:F34	R:R:L38	54.9642	14.61	No	No	0	7	7
42	R:R:F34	R:R:P76	54.3054	4.33	No	No	0	7	9
43	R:R:C389	R:R:N427	17.7313	7.87	No	No	0	9	9
44	R:R:C389	R:R:F430	15.8064	2.79	No	No	0	9	7
45	R:R:N41	R:R:P432	55.9553	8.15	Yes	No	0	9	9
46	R:R:P432	R:R:V44	47.018	1.77	No	Yes	0	9	9
47	R:R:F442	R:R:V44	37.7943	5.24	Yes	Yes	7	9	9
48	R:R:F442	R:R:V47	14.6949	10.49	Yes	No	0	9	8
49	R:R:A48	R:R:F442	12.0596	2.77	No	Yes	0	7	9
50	R:R:V110	R:R:W390	37.3131	4.9	No	Yes	1	9	9
51	R:R:P348	R:R:V110	46.8691	3.53	Yes	No	1	9	9
52	R:R:F111	R:R:P348	29.5675	2.89	Yes	Yes	1	8	9
53	R:R:F111	R:R:I146	36.511	2.51	Yes	No	0	8	8
54	R:R:I146	R:R:L112	35.159	4.28	No	No	0	8	9
55	R:R:H63	R:R:L112	34.5918	2.57	Yes	No	0	8	9
56	R:R:H63	R:R:I59	22.3718	2.65	Yes	Yes	0	8	6
57	R:R:I59	R:R:T58	12.5408	3.04	Yes	No	0	6	8
58	R:R:L113	R:R:N431	58.711	4.12	No	No	0	8	9
59	R:R:L113	R:R:Y435	87.9519	7.03	No	Yes	0	8	9
60	R:R:I116	R:R:Y435	61.8848	4.84	No	Yes	8	9	9
61	R:R:I116	R:R:W60	73.0851	3.52	No	Yes	0	9	8
62	R:R:V56	R:R:W60	23.2999	3.68	No	Yes	0	8	8
63	R:R:R134	R:R:V56	21.375	9.15	Yes	No	0	9	8
64	R:R:D119	R:R:W60	23.2942	7.82	No	Yes	0	9	8
65	R:R:D119	R:R:R134	21.4895	11.91	No	Yes	0	9	9
66	R:R:C143	R:R:H63	30.3753	14.74	No	Yes	0	8	8
67	R:R:C143	R:R:W60	31.0341	5.22	No	Yes	0	8	8
68	R:R:H63	R:R:W147	32.0195	7.41	Yes	Yes	0	8	9
69	R:R:D68	R:R:L64	31.9278	4.07	Yes	No	0	9	9
70	R:R:L113	R:R:L64	31.9966	4.15	No	No	0	8	9
71	R:R:L66	R:R:W147	22.3718	2.28	No	Yes	0	4	9
72	R:R:L66	R:R:L70	19.9313	2.77	No	No	0	4	6
73	R:R:L70	R:R:N105	17.4792	6.87	No	No	0	6	9
74	R:R:F77	R:R:I98	25.4082	2.51	No	Yes	0	8	8
75	R:R:F77	R:R:Y90	19.5932	4.13	No	Yes	0	8	7
76	R:R:I98	R:R:W88	28.3414	4.7	Yes	Yes	2	8	9
77	R:R:W88	R:R:Y90	26.7488	5.79	Yes	Yes	0	9	7
78	R:R:P89	R:R:Y90	30.4898	2.78	No	Yes	0	8	7
79	R:R:L84	R:R:P89	16.0928	3.28	No	No	9	8	8
80	R:R:I101	R:R:N105	15.0158	1.42	No	No	0	5	9
81	R:R:I101	R:R:L97	12.5408	2.85	No	No	0	5	6
82	R:R:F158	R:R:L97	10.0544	4.87	No	No	0	8	6
83	R:R:F386	R:R:W390	37.3761	7.02	Yes	Yes	1	9	9
84	R:R:F111	R:R:V343	17.7084	2.62	Yes	No	0	8	4
85	R:R:P348	R:R:T114	18.0349	3.5	Yes	No	0	9	8
86	R:R:I351	R:R:T114	16.4537	4.56	No	No	0	6	8
87	R:R:F386	R:R:M352	41.1859	4.98	Yes	No	0	9	8
88	R:R:M352	R:R:S117	20.3495	4.6	No	No	0	8	9
89	R:R:S117	R:R:Y356	20.8479	6.36	No	Yes	0	9	9
90	R:R:R120	R:R:Y356	22.2572	9.26	No	Yes	0	9	9
91	R:R:M352	R:R:V383	20.3495	3.04	No	No	0	8	8
92	R:R:V383	R:R:Y356	20.8135	5.05	No	Yes	0	8	9
93	R:R:I351	R:R:L118	14.9126	4.28	No	No	0	6	8
94	R:R:C355	R:R:L118	13.4059	3.17	No	No	0	9	8
95	R:R:C121	R:R:C355	11.9622	5.46	No	No	0	9	9
96	R:R:C130	R:R:R134	35.7605	4.18	No	Yes	0	7	9
97	R:R:C130	R:R:L122	15.7949	4.76	No	No	0	7	7
98	R:R:C130	R:R:W129	16.6772	2.61	No	No	0	7	6
99	R:R:H133	R:R:W129	12.5236	19.04	No	No	0	8	6
100	R:R:F176	R:R:L333	22.177	15.83	Yes	No	3	4	3
101	R:R:L333	R:R:L401	21.2432	2.77	No	No	0	3	7
102	R:R:L401	R:R:V334	16.6142	2.98	No	No	0	7	4
103	R:R:H394	R:R:Y393	21.1515	6.53	No	Yes	0	9	9
104	R:R:F345	R:R:H394	16.0298	19.23	No	No	0	9	9
105	R:R:F345	R:R:T391	15.3595	5.19	No	Yes	0	9	6
106	R:R:A379	R:R:Y356	29.8138	4	No	Yes	0	7	9
107	R:R:V382	R:R:Y356	20.3724	3.79	Yes	Yes	0	8	9
108	R:R:V382	R:R:Y435	20.8536	3.79	Yes	Yes	0	8	9
109	R:R:A379	R:R:V360	26.0899	1.7	No	Yes	0	7	6
110	R:R:T375	R:R:V360	11.1028	1.59	No	Yes	0	7	6
111	R:R:V378	R:R:V382	17.1298	1.6	No	Yes	0	8	8
112	R:R:K374	R:R:V378	10.5987	3.04	No	No	0	9	8
113	R:R:F386	R:R:L387	31.7216	3.65	Yes	Yes	0	9	6
114	R:R:P392	R:R:T391	32.4721	3.5	No	Yes	0	9	6
115	R:R:C420	R:R:P392	28.267	1.88	No	No	0	6	9
116	R:R:C420	R:R:F396	26.1472	8.38	No	No	0	6	4
117	R:R:F396	R:R:L413	24.016	7.31	No	Yes	0	4	7
118	R:R:L409	R:R:L413	17.7313	2.77	No	Yes	0	3	7
119	R:R:L409	R:R:T407	13.3658	1.47	No	No	0	3	7
120	R:R:V342	R:R:V343	17.1584	1.6	No	No	0	6	4
121	R:R:I338	R:R:V334	16.385	1.54	No	No	0	6	4
122	R:R:I338	R:R:V342	16.6886	1.54	No	No	0	6	6
123	L:L:L14	R:R:I98	18.4303	2.85	Yes	Yes	2	0	8
124	R:R:L75	R:R:P76	13.658	1.64	No	No	0	9	9
125	R:R:L79	R:R:P76	40.6359	1.64	Yes	No	0	6	9
126	R:R:L387	R:R:T391	23.0879	2.95	Yes	Yes	0	6	6
127	R:R:K126	R:R:L122	11.8591	2.82	No	No	0	6	7
128	R:R:F386	R:R:V110	10.8966	2.62	Yes	No	1	9	9
129	R:R:I116	R:R:R120	12.5294	3.76	No	No	8	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:A9	R:R:F164	8.32	0	No	No	0	3	0	1
L:L:S10	R:R:G173	3.71	0	No	No	0	1	0	1
L:L:K11	R:R:G86	5.23	5	No	No	0	7	0	1
L:L:K11	R:R:R171	6.19	5	No	No	0	1	0	1
L:L:L14	R:R:I98	2.85	2	Yes	Yes	0	8	0	1
L:L:L14	R:R:P99	4.93	2	Yes	Yes	0	8	0	1
L:L:L14	R:R:I102	2.85	2	Yes	No	0	8	0	1
L:L:A15	R:R:M106	3.22	0	No	No	0	9	0	1
L:L:R16	R:R:Y393	20.58	1	Yes	Yes	0	9	0	1
L:L:R16	R:R:G397	3	1	Yes	No	0	8	0	1
L:L:R16	R:R:D417	13.1	1	Yes	No	0	8	0	1
L:L:R16	R:R:I421	7.52	1	Yes	No	0	4	0	1
R:R:F77	R:R:S74	2.64	0	No	No	8	9	2	2
R:R:I102	R:R:S74	4.64	0	No	No	8	9	1	2
R:R:F77	R:R:I98	2.51	0	No	Yes	8	8	2	1
R:R:G86	R:R:H81	3.18	5	No	No	7	7	1	2
R:R:G86	R:R:R171	3	5	No	No	7	1	1	1
R:R:I98	R:R:W88	4.7	2	Yes	Yes	8	9	1	2
R:R:I98	R:R:P99	3.39	2	Yes	Yes	8	8	1	1
R:R:P99	R:R:V157	3.53	2	Yes	No	8	9	1	2
R:R:P99	R:R:R161	11.53	2	Yes	No	8	8	1	2
R:R:M106	R:R:W390	5.82	0	No	Yes	9	9	1	2
R:R:E162	R:R:F164	11.66	0	No	No	5	3	2	1
R:R:F164	R:R:G173	3.01	0	No	No	3	1	1	1
R:R:H169	R:R:R171	5.64	0	No	No	3	1	2	1
R:R:R340	R:R:Y393	5.14	1	Yes	Yes	9	9	2	1
R:R:W390	R:R:Y393	6.75	1	Yes	Yes	9	9	2	1
R:R:A424	R:R:W390	7.78	1	No	Yes	9	9	2	2
R:R:H394	R:R:Y393	6.53	0	No	Yes	9	9	2	1
R:R:A424	R:R:Y393	2.67	1	No	Yes	9	9	2	1
R:R:D417	R:R:I421	2.8	1	No	No	8	4	1	1
L:L:L14	R:R:S78	1.5	2	Yes	No	0	8	0	1
R:R:L30	R:R:S78	1.5	0	No	No	6	8	2	1
R:R:D417	R:R:S400	1.47	1	No	No	8	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IA8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.51
Number of Linked Nodes	268
Number of Links	297
Number of Hubs	36
Number of Links mediated by Hubs	138
Number of Communities	11
Number of Nodes involved in Communities	50
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	130
Number Of Links MetaPath	129
Number of Shortest Paths	58621
Length Of Smallest Path	3
Average Path Length	14.592
Length of Longest Path	36
Minimum Path Strength	1.395
Average Path Strength	5.49544
Maximum Path Strength	16.84
Minimum Path Correlation	0.7
Average Path Correlation	0.927858
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	48.8506
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.7715
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8IA8_nogp_Chain_R W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y K F G V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	10.1016/j.cell.2023.09.020
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	10.1038/s41589-023-01339-w
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	10.1038/s41589-023-01339-w

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