psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F3	R:R:G173	4.52	No	No	0	0	1
2	L:L:K4	R:R:L333	5.64	No	Yes	0	0	3
3	L:L:P5	R:R:R171	10.09	No	No	0	0	1
4	L:L:M6	L:L:P7	3.35	Yes	No	0	0	0
5	L:L:M6	L:L:R10	3.72	Yes	Yes	0	0	0
6	L:L:M6	R:R:Y174	11.97	Yes	No	0	0	7
7	L:L:M6	R:R:L333	4.24	Yes	Yes	0	0	3
8	L:L:P7	R:R:D417	6.44	No	Yes	1	0	8
9	L:L:P7	R:R:I421	3.39	No	Yes	1	0	4
10	L:L:?9	L:L:L8	4.22	Yes	Yes	1	0	0
11	L:L:L8	R:R:H81	9	Yes	Yes	1	0	7
12	L:L:L8	R:R:W88	5.69	Yes	Yes	1	0	9
13	L:L:L8	R:R:I98	4.28	Yes	Yes	1	0	8
14	L:L:L8	R:R:P99	6.57	Yes	No	1	0	8
15	L:L:L8	R:R:I102	4.28	Yes	Yes	1	0	8
16	L:L:?9	L:L:R10	6.18	Yes	Yes	1	0	0
17	L:L:?9	R:R:I102	4.36	Yes	Yes	1	0	8
18	L:L:?9	R:R:M106	4.31	Yes	No	1	0	9
19	L:L:?9	R:R:Y393	7.15	Yes	Yes	1	0	9
20	L:L:?9	R:R:I421	5.81	Yes	Yes	1	0	4
21	L:L:R10	R:R:R340	6.4	Yes	Yes	1	0	9
22	L:L:R10	R:R:Y393	14.4	Yes	Yes	1	0	9
23	L:L:R10	R:R:D417	17.87	Yes	Yes	1	0	8
24	L:L:R10	R:R:I421	7.52	Yes	Yes	1	0	4
25	R:R:E20	R:R:W18	5.45	No	No	0	4	1
26	R:R:Q85	R:R:W18	3.29	No	No	0	5	1
27	R:R:I24	R:R:N19	9.91	No	No	0	7	1
28	R:R:E20	R:R:V23	5.7	No	No	0	4	4
29	R:R:P21	R:R:P22	5.84	No	No	0	6	4
30	R:R:P22	R:R:S415	3.56	No	No	0	4	5
31	R:R:P22	R:R:W416	9.46	No	No	0	4	7
32	R:R:I24	R:R:V28	3.07	No	No	0	7	6
33	R:R:I29	R:R:L25	4.28	No	No	0	7	5
34	R:R:L25	R:R:V419	7.45	No	No	0	5	5
35	R:R:L82	R:R:S26	3	No	No	0	7	8
36	R:R:S26	R:R:V419	3.23	No	No	0	8	5
37	R:R:A422	R:R:S26	3.42	No	No	0	8	8
38	R:R:A422	R:R:I29	3.25	No	No	0	8	7
39	R:R:L30	R:R:L75	8.3	Yes	Yes	0	6	9
40	R:R:L30	R:R:S78	3	Yes	No	0	6	8
41	R:R:L30	R:R:L79	8.3	Yes	No	0	6	6
42	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
43	R:R:L79	R:R:S31	3	No	No	0	6	7
44	R:R:L32	R:R:L36	4.15	No	No	0	6	8
45	R:R:L75	R:R:T33	4.42	Yes	No	0	9	8
46	R:R:A426	R:R:T33	3.36	No	No	0	8	8
47	R:R:C429	R:R:T33	5.07	No	No	0	9	8
48	R:R:F34	R:R:L38	3.65	No	No	0	7	7
49	R:R:F34	R:R:L75	4.87	No	Yes	0	7	9
50	R:R:F34	R:R:P76	7.22	No	No	0	7	9
51	R:R:L38	R:R:P39	3.28	No	No	0	7	7
52	R:R:D68	R:R:N41	8.08	Yes	Yes	0	9	9
53	R:R:N41	R:R:P432	11.4	Yes	No	0	9	9
54	R:R:T65	R:R:V44	4.76	No	Yes	0	9	9
55	R:R:A436	R:R:V44	3.39	No	Yes	0	8	9
56	R:R:L50	R:R:W46	6.83	No	No	0	4	6
57	R:R:S449	R:R:W46	4.94	No	No	0	9	6
58	R:R:K51	R:R:V47	3.04	No	Yes	3	9	8
59	R:R:M52	R:R:V47	4.56	Yes	Yes	3	9	8
60	R:R:K445	R:R:V47	3.04	Yes	Yes	3	7	8
61	R:R:S449	R:R:V47	3.23	No	Yes	3	9	8
62	R:R:K445	R:R:K51	21.55	Yes	No	3	7	9
63	R:R:K51	R:R:S449	6.12	No	No	3	9	9
64	R:R:M52	R:R:T58	3.01	Yes	No	0	9	8
65	R:R:F442	R:R:M52	7.46	Yes	Yes	0	9	9
66	R:R:K445	R:R:M52	7.2	Yes	Yes	3	7	9
67	R:R:I59	R:R:R54	3.76	No	No	0	6	7
68	R:R:T55	R:R:T58	4.71	No	No	0	9	8
69	R:R:R134	R:R:V56	7.85	Yes	No	0	9	8
70	R:R:N57	R:R:R134	3.62	No	Yes	0	8	9
71	R:R:I59	R:R:V136	3.07	No	No	0	6	7
72	R:R:A139	R:R:I59	4.87	No	No	0	7	6
73	R:R:I116	R:R:W60	3.52	No	Yes	0	9	8
74	R:R:D119	R:R:W60	13.4	No	Yes	0	9	8
75	R:R:A139	R:R:W60	5.19	No	Yes	0	7	8
76	R:R:I142	R:R:W60	7.05	No	Yes	0	5	8
77	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
78	R:R:F442	R:R:F61	4.29	Yes	No	0	9	8
79	R:R:C143	R:R:H63	17.69	No	No	0	8	8
80	R:R:H63	R:R:W147	7.41	No	Yes	0	8	9
81	R:R:D68	R:R:L64	5.43	Yes	Yes	2	9	9
82	R:R:L64	R:R:S109	3	Yes	No	2	9	9
83	R:R:L113	R:R:L64	5.54	No	Yes	2	8	9
84	R:R:L64	R:R:N431	5.49	Yes	Yes	2	9	9
85	R:R:L64	R:R:Y435	3.52	Yes	Yes	2	9	9
86	R:R:L66	R:R:W147	4.56	No	Yes	0	4	9
87	R:R:A67	R:R:N105	4.69	No	No	0	9	9
88	R:R:A67	R:R:W147	3.89	No	Yes	0	9	9
89	R:R:D68	R:R:S109	5.89	Yes	No	2	9	9
90	R:R:D68	R:R:S428	4.42	Yes	No	0	9	9
91	R:R:D68	R:R:N431	8.08	Yes	Yes	2	9	9
92	R:R:L70	R:R:N105	4.12	No	No	0	6	9
93	R:R:C71	R:R:N105	6.3	No	No	0	8	9
94	R:R:C71	R:R:S425	3.44	No	No	0	8	8
95	R:R:C71	R:R:S428	6.89	No	No	0	8	9
96	R:R:I102	R:R:S74	4.64	Yes	No	0	8	9
97	R:R:L75	R:R:S425	3	Yes	No	0	9	8
98	R:R:F77	R:R:I98	10.05	No	Yes	0	8	8
99	R:R:L82	R:R:S78	3	No	No	0	7	8
100	R:R:G86	R:R:H81	3.18	No	Yes	1	7	7
101	R:R:H81	R:R:W88	7.41	Yes	Yes	1	7	9
102	R:R:H81	R:R:R171	5.64	Yes	No	1	7	1
103	R:R:H418	R:R:L82	7.71	No	No	0	4	7
104	R:R:L84	R:R:P89	3.28	Yes	No	0	8	8
105	R:R:G86	R:R:R171	3	No	No	1	7	1
106	R:R:H169	R:R:Q87	11.13	No	No	0	3	6
107	R:R:P89	R:R:W88	5.4	No	Yes	1	8	9
108	R:R:W88	R:R:Y90	7.72	Yes	No	1	9	7
109	R:R:C95	R:R:W88	13.06	No	Yes	1	9	9
110	R:R:I98	R:R:W88	4.7	Yes	Yes	1	8	9
111	R:R:P89	R:R:Y90	4.17	No	No	1	8	7
112	R:R:L94	R:R:Y90	8.21	No	No	0	8	7
113	R:R:K96	R:R:R92	9.9	No	No	0	8	1
114	R:R:F93	R:R:L97	4.87	No	No	0	4	6
115	R:R:C95	R:R:I163	3.27	No	No	1	9	6
116	R:R:C172	R:R:C95	7.28	No	No	1	8	9
117	R:R:F158	R:R:K96	9.93	No	No	0	8	8
118	R:R:K96	R:R:R161	3.71	No	No	0	8	8
119	R:R:I98	R:R:P99	11.85	Yes	No	1	8	8
120	R:R:I102	R:R:I98	5.89	Yes	Yes	1	8	8
121	R:R:P99	R:R:R161	5.76	No	No	0	8	8
122	R:R:S100	R:R:V157	3.23	No	No	0	8	9
123	R:R:C154	R:R:V103	3.42	No	No	0	8	5
124	R:R:R340	R:R:V103	3.92	Yes	No	0	9	5
125	R:R:C154	R:R:L104	3.17	No	No	0	8	8
126	R:R:M106	R:R:W390	5.82	No	Yes	1	9	9
127	R:R:M106	R:R:Y393	3.59	No	Yes	1	9	9
128	R:R:F107	R:R:M153	7.46	Yes	Yes	1	8	8
129	R:R:F107	R:R:R340	7.48	Yes	Yes	1	8	9
130	R:R:F107	R:R:G344	3.01	Yes	No	0	8	9
131	R:R:F107	R:R:Y393	5.16	Yes	Yes	1	8	9
132	R:R:A108	R:R:W147	5.19	No	Yes	0	9	9
133	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
134	R:R:F386	R:R:V110	5.24	Yes	No	1	9	9
135	R:R:V110	R:R:W390	8.58	No	Yes	1	9	9
136	R:R:F111	R:R:V149	3.93	Yes	No	0	8	4
137	R:R:F111	R:R:M153	6.22	Yes	Yes	1	8	8
138	R:R:F111	R:R:V343	3.93	Yes	No	1	8	4
139	R:R:I146	R:R:L112	4.28	No	No	0	8	9
140	R:R:L113	R:R:N431	9.61	No	Yes	2	8	9
141	R:R:L113	R:R:Y435	9.38	No	Yes	2	8	9
142	R:R:P348	R:R:T114	3.5	Yes	No	0	9	8
143	R:R:I351	R:R:T114	4.56	No	No	0	6	8
144	R:R:I116	R:R:R120	5.01	No	No	2	9	9
145	R:R:I116	R:R:Y435	7.25	No	Yes	2	9	9
146	R:R:M352	R:R:S117	6.13	No	No	0	8	9
147	R:R:C355	R:R:S117	6.89	No	No	0	9	9
148	R:R:S117	R:R:Y356	5.09	No	Yes	0	9	9
149	R:R:I351	R:R:L118	4.28	No	No	0	6	8
150	R:R:C355	R:R:L118	3.17	No	No	0	9	8
151	R:R:D119	R:R:V123	4.38	No	No	4	9	5
152	R:R:D119	R:R:R134	11.91	No	Yes	4	9	9
153	R:R:R120	R:R:Y356	11.32	No	Yes	0	9	9
154	R:R:R120	R:R:Y435	5.14	No	Yes	2	9	9
155	R:R:C121	R:R:F125	4.19	No	No	0	9	6
156	R:R:C121	R:R:C355	7.28	No	No	0	9	9
157	R:R:C121	R:R:I359	3.27	No	No	0	9	9
158	R:R:C130	R:R:L122	4.76	Yes	No	0	7	7
159	R:R:C130	R:R:V123	5.12	Yes	No	4	7	5
160	R:R:R134	R:R:V123	6.54	Yes	No	4	9	5
161	R:R:F125	R:R:V124	3.93	No	No	0	6	9
162	R:R:F125	R:R:F358	4.29	No	No	0	6	6
163	R:R:H133	R:R:W129	17.98	No	No	0	8	6
164	R:R:C130	R:R:R134	4.18	Yes	Yes	4	7	9
165	R:R:H133	R:R:N132	7.65	No	No	0	8	8
166	R:R:I142	R:R:M138	4.37	No	No	0	5	6
167	R:R:M153	R:R:R340	3.72	Yes	Yes	1	8	9
168	R:R:M153	R:R:V343	4.56	Yes	No	1	8	4
169	R:R:I155	R:R:P156	5.08	No	No	0	5	9
170	R:R:I336	R:R:P156	5.08	No	No	0	7	9
171	R:R:I336	R:R:V157	3.07	No	No	0	7	9
172	R:R:V159	R:R:Y160	7.57	No	No	0	4	8
173	R:R:R161	R:R:Y174	13.38	No	No	0	8	7
174	R:R:C172	R:R:I163	4.91	No	No	1	8	6
175	R:R:P332	R:R:T331	3.5	No	No	0	4	4
176	R:R:L333	R:R:T337	4.42	Yes	No	5	3	7
177	R:R:L333	R:R:L401	4.15	Yes	No	5	3	7
178	R:R:L401	R:R:T337	5.9	No	No	5	7	7
179	R:R:R340	R:R:Y393	6.17	Yes	Yes	1	9	9
180	R:R:H394	R:R:L341	3.86	Yes	No	0	9	6
181	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
182	R:R:F345	R:R:T391	9.08	No	No	0	9	6
183	R:R:F345	R:R:H394	15.84	No	Yes	0	9	9
184	R:R:F386	R:R:M352	4.98	Yes	No	0	9	8
185	R:R:I353	R:R:V383	3.07	No	No	0	5	8
186	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	9
187	R:R:V382	R:R:Y356	3.79	Yes	Yes	0	8	9
188	R:R:V383	R:R:Y356	5.05	No	Yes	0	8	9
189	R:R:Q372	R:R:V360	4.3	No	No	0	5	6
190	R:R:F376	R:R:V360	7.87	No	No	0	4	6
191	R:R:R362	R:R:R365	10.66	No	No	0	7	4
192	R:R:F368	R:R:R362	4.28	No	No	0	5	7
193	R:R:F368	R:R:M363	9.95	No	Yes	0	5	7
194	R:R:M363	R:R:S371	3.07	Yes	No	0	7	7
195	R:R:M363	R:R:Q372	5.44	Yes	No	0	7	5
196	R:R:M363	R:R:T375	6.02	Yes	No	0	7	7
197	R:R:Q364	R:R:Q372	7.68	No	No	0	5	5
198	R:R:F368	R:R:R367	7.48	No	No	0	5	6
199	R:R:K374	R:R:V378	6.07	No	Yes	0	9	8
200	R:R:L438	R:R:V378	4.47	No	Yes	0	7	8
201	R:R:V382	R:R:Y435	6.31	Yes	Yes	0	8	9
202	R:R:L434	R:R:V385	4.47	No	No	0	9	7
203	R:R:F386	R:R:L387	3.65	Yes	No	0	9	6
204	R:R:F386	R:R:W390	6.01	Yes	Yes	1	9	9
205	R:R:C389	R:R:N427	11.02	No	No	0	9	9
206	R:R:W390	R:R:Y393	4.82	Yes	Yes	1	9	9
207	R:R:H394	R:R:W390	4.23	Yes	Yes	1	9	9
208	R:R:A424	R:R:W390	7.78	No	Yes	1	9	9
209	R:R:N427	R:R:W390	7.91	No	Yes	0	9	9
210	R:R:P392	R:R:T391	3.5	No	No	0	9	6
211	R:R:I395	R:R:T391	3.04	No	No	0	5	6
212	R:R:C420	R:R:P392	3.77	No	No	0	6	9
213	R:R:H394	R:R:Y393	9.8	Yes	Yes	1	9	9
214	R:R:A424	R:R:Y393	4	No	Yes	1	9	9
215	R:R:F396	R:R:L413	6.09	No	Yes	0	4	7
216	R:R:D417	R:R:F396	3.58	Yes	No	0	8	4
217	R:R:C420	R:R:F396	8.38	No	No	0	6	4
218	R:R:G410	R:R:T403	3.64	No	Yes	6	3	2
219	R:R:L413	R:R:T403	4.42	Yes	Yes	6	7	2
220	R:R:D404	R:R:P405	12.88	No	No	7	4	4
221	R:R:D404	R:R:E406	5.2	No	No	7	4	1
222	R:R:E406	R:R:P405	4.72	No	No	7	1	4
223	R:R:M414	R:R:P405	3.35	No	No	0	2	4
224	R:R:P408	R:R:T407	3.5	No	No	0	4	7
225	R:R:G410	R:R:L413	5.13	No	Yes	6	3	7
226	R:R:K411	R:R:S415	7.65	No	No	0	2	5
227	R:R:V419	R:R:W416	7.36	No	No	0	5	7
228	R:R:D417	R:R:I421	5.6	Yes	Yes	1	8	4
229	R:R:A426	R:R:F430	4.16	No	No	0	8	7
230	R:R:N427	R:R:N431	10.9	No	Yes	0	9	9
231	R:R:N431	R:R:Y435	5.81	Yes	Yes	2	9	9
232	R:R:F442	R:R:G439	4.52	Yes	No	0	9	9
233	R:R:K440	R:R:R443	7.43	No	No	0	7	9
234	R:R:K440	R:R:K444	5.75	No	No	0	7	5
235	R:R:K444	R:R:Q448	8.14	No	No	0	5	7
236	R:R:I450	R:R:Q451	4.12	No	No	0	4	6
237	R:R:L43	R:R:V44	2.98	No	Yes	0	8	9
238	R:R:L437	R:R:V44	2.98	No	Yes	0	7	9
239	R:R:L401	R:R:V334	2.98	No	No	0	7	4
240	R:R:L45	R:R:T65	2.95	No	No	0	8	9
241	R:R:L413	R:R:T412	2.95	Yes	No	0	7	6
242	R:R:I101	R:R:I98	2.94	No	Yes	0	5	8
243	R:R:I142	R:R:I146	2.94	No	No	0	5	8
244	R:R:N41	R:R:T65	2.92	Yes	No	0	9	9
245	R:R:N57	R:R:T55	2.92	No	No	0	8	9
246	R:R:G173	R:R:Y174	2.9	No	No	0	1	7
247	R:R:F433	R:R:P432	2.89	No	No	0	6	9
248	R:R:K411	R:R:M414	2.88	No	No	0	2	2
249	R:R:I163	R:R:N170	2.83	No	No	0	6	4
250	R:R:K126	R:R:L122	2.82	No	No	0	6	7
251	R:R:L45	R:R:L62	2.77	No	No	0	8	8
252	R:R:L69	R:R:L73	2.77	No	No	0	7	8
253	R:R:A150	R:R:F111	2.77	No	Yes	0	9	8
254	R:R:L341	R:R:L346	2.77	No	No	0	6	8
255	R:R:L399	R:R:L413	2.77	No	Yes	0	9	7
256	R:R:L69	R:R:N41	2.75	No	Yes	0	7	9
257	R:R:L84	R:R:Q87	2.66	Yes	No	0	8	6
258	R:R:F158	R:R:S100	2.64	No	No	0	8	8
259	R:R:R362	R:R:V124	2.62	No	No	0	7	9
260	R:R:F430	R:R:V385	2.62	No	No	0	7	7
261	R:R:C130	R:R:W129	2.61	Yes	No	0	7	6
262	R:R:A115	R:R:W60	2.59	No	Yes	0	7	8
263	R:R:D167	R:R:H169	2.52	No	No	0	3	3
264	R:R:D441	R:R:F442	2.39	No	Yes	0	7	9
265	L:L:F3	R:R:F164	2.14	No	No	0	0	3
266	R:R:G40	R:R:P39	2.03	No	No	0	9	7
267	R:R:C72	R:R:G37	1.96	No	No	0	8	9
268	R:R:C429	R:R:G37	1.96	No	No	0	9	9
269	R:R:C140	R:R:G137	1.96	No	No	0	4	5
270	R:R:G49	R:R:L50	1.71	No	No	0	7	4
271	R:R:G49	R:R:L62	1.71	No	No	0	7	8
272	R:R:G91	R:R:L94	1.71	No	No	0	9	8
273	R:R:C389	R:R:V388	1.71	No	No	0	9	6
274	R:R:A446	R:R:V47	1.7	No	Yes	0	8	8
275	R:R:A48	R:R:T58	1.68	No	No	0	7	8
276	R:R:A335	R:R:T331	1.68	No	No	0	5	4
277	R:R:K126	R:R:P127	1.67	No	No	0	6	9
278	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
279	R:R:L423	R:R:P392	1.64	No	No	0	8	9
280	R:R:L409	R:R:P408	1.64	No	No	0	3	4
281	R:R:S349	R:R:V350	1.62	No	No	0	4	4
282	R:R:A83	R:R:M27	1.61	No	No	0	5	6
283	R:R:V378	R:R:V382	1.6	Yes	Yes	0	8	8
284	R:R:V381	R:R:V382	1.6	No	Yes	0	7	8
285	R:R:V381	R:R:V385	1.6	No	No	0	7	7
286	R:R:A80	R:R:L84	1.58	No	Yes	0	5	8
287	R:R:A83	R:R:L84	1.58	No	Yes	0	5	8
288	R:R:E20	R:R:P21	1.57	No	No	0	4	6
289	R:R:I155	R:R:V152	1.54	No	No	0	5	5
290	R:R:I338	R:R:V334	1.54	No	No	0	6	4
291	R:R:I338	R:R:V398	1.54	No	No	0	6	7
292	L:L:R10	R:R:G397	1.5	Yes	No	0	0	8
293	R:R:L387	R:R:S349	1.5	No	No	0	6	4
294	R:R:G366	R:R:R367	1.5	No	No	0	2	6
295	R:R:L32	R:R:V28	1.49	No	No	0	6	6
296	R:R:L402	R:R:T403	1.47	No	Yes	0	5	2
297	R:R:L409	R:R:T403	1.47	No	Yes	0	3	2
298	R:R:I24	R:R:M27	1.46	No	No	0	7	6
299	R:R:N170	R:R:T165	1.46	No	No	0	4	4
300	R:R:D167	R:R:T166	1.45	No	No	0	3	1
301	R:R:Q53	R:R:T55	1.42	No	No	0	6	9
302	R:R:G144	R:R:W147	1.41	No	Yes	0	5	9
303	R:R:L32	R:R:L35	1.38	No	No	0	6	6
304	R:R:K445	R:R:Q448	1.36	Yes	No	0	7	7
305	R:R:D167	R:R:N168	1.35	No	No	0	3	5
306	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
307	R:R:F376	R:R:V380	1.31	No	No	0	4	3
308	R:R:R377	R:R:V378	1.31	No	Yes	0	5	8
309	R:R:F151	R:R:I155	1.26	No	No	0	5	5
310	R:R:T331	R:R:Y160	1.25	No	No	0	4	8
311	R:R:F158	R:R:L97	1.22	No	No	0	8	6
312	R:R:I128	R:R:W129	1.17	No	No	0	7	6
313	R:R:E162	R:R:R92	1.16	No	No	0	5	1
314	R:R:F358	R:R:F361	1.07	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M6	5.82	4	0	0
2	L:L:L8	5.67333	6	1	0
3	L:L:?9	5.33833	6	1	0
4	L:L:R10	8.22714	7	1	0
5	R:R:L30	5.6875	4	0	6
6	R:R:N41	6.2875	4	0	9
7	R:R:V44	3.5275	4	0	9
8	R:R:V47	3.114	5	3	8
9	R:R:M52	5.5575	4	3	9
10	R:R:W60	5.945	6	0	8
11	R:R:L64	4.596	5	2	9
12	R:R:D68	6.38	5	2	9
13	R:R:L75	5.1475	4	0	9
14	R:R:H81	6.3075	4	1	7
15	R:R:L84	2.275	4	0	8
16	R:R:W88	7.33	6	1	9
17	R:R:I98	6.61833	6	1	8
18	R:R:I102	4.7925	4	1	8
19	R:R:F107	5.7775	4	1	8
20	R:R:F111	4.2125	4	1	8
21	R:R:C130	4.1675	4	4	7
22	R:R:R134	6.82	5	4	9
23	R:R:W147	4.492	5	0	9
24	R:R:M153	5.49	4	1	8
25	R:R:L333	4.6125	4	5	3
26	R:R:R340	5.538	5	1	9
27	R:R:P348	3.1825	4	0	9
28	R:R:Y356	6.118	5	0	9
29	R:R:M363	6.12	4	0	7
30	R:R:V378	3.3625	4	0	8
31	R:R:V382	3.325	4	0	8
32	R:R:F386	4.97	4	1	9
33	R:R:W390	6.45	7	1	9
34	R:R:Y393	6.88625	8	1	9
35	R:R:H394	8.4325	4	1	9
36	R:R:T403	2.75	4	6	2
37	R:R:L413	4.272	5	6	7
38	R:R:D417	8.3725	4	1	8
39	R:R:I421	5.58	4	1	4
40	R:R:N431	7.978	5	2	9
41	R:R:Y435	6.235	6	2	9
42	R:R:F442	4.665	4	0	9
43	R:R:K445	8.2875	4	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M6	R:R:Y174	16.7483	11.97	Yes	No	0	0	7
2	R:R:R161	R:R:Y174	14.1269	13.38	No	No	0	8	7
3	R:R:P99	R:R:R161	23.4564	5.76	No	No	0	8	8
4	L:L:L8	R:R:P99	22.9999	6.57	Yes	No	1	0	8
5	L:L:M6	L:L:R10	23.4012	3.72	Yes	Yes	0	0	0
6	L:L:R10	R:R:D417	13.3905	17.87	Yes	Yes	1	0	8
7	L:L:L8	R:R:W88	42.0971	5.69	Yes	Yes	1	0	9
8	L:L:?9	R:R:M106	36.7991	4.31	Yes	No	1	0	9
9	L:L:R10	R:R:Y393	30.912	14.4	Yes	Yes	1	0	9
10	R:R:W390	R:R:Y393	75.6784	4.82	Yes	Yes	1	9	9
11	R:R:N427	R:R:W390	100	7.91	No	Yes	0	9	9
12	R:R:N427	R:R:N431	99.1827	10.9	No	Yes	0	9	9
13	R:R:D68	R:R:N431	60.2187	8.08	Yes	Yes	2	9	9
14	R:R:D68	R:R:S428	51.4009	4.42	Yes	No	0	9	9
15	R:R:C71	R:R:S428	49.9135	6.89	No	No	0	8	9
16	R:R:C71	R:R:S425	47.7633	3.44	No	No	0	8	8
17	R:R:L75	R:R:S425	46.0808	3	Yes	No	0	9	8
18	R:R:L30	R:R:L75	38.0803	8.3	Yes	Yes	0	6	9
19	R:R:A422	R:R:L30	28.7692	3.15	No	Yes	0	8	6
20	R:R:A422	R:R:S26	24.0381	3.42	No	No	0	8	8
21	R:R:S26	R:R:V419	22.6391	3.23	No	No	0	8	5
22	R:R:V419	R:R:W416	21.1517	7.36	No	No	0	5	7
23	R:R:P22	R:R:W416	19.5685	9.46	No	No	0	4	7
24	R:R:P89	R:R:W88	28.9606	5.4	No	Yes	1	8	9
25	R:R:L84	R:R:P89	27.3628	3.28	Yes	No	0	8	8
26	R:R:A83	R:R:L84	14.8706	1.58	No	Yes	0	5	8
27	R:R:A83	R:R:M27	13.0371	1.61	No	No	0	5	6
28	R:R:I24	R:R:M27	11.1962	1.46	No	No	0	7	6
29	R:R:N431	R:R:Y435	61.5257	5.81	Yes	Yes	2	9	9
30	R:R:V382	R:R:Y435	16.023	6.31	Yes	Yes	0	8	9
31	R:R:V381	R:R:V382	10.9827	1.6	No	Yes	0	7	8
32	R:R:D68	R:R:N41	30.032	8.08	Yes	Yes	0	9	9
33	R:R:N41	R:R:T65	22.1899	2.92	Yes	No	0	9	9
34	R:R:L45	R:R:T65	14.2741	2.95	No	No	0	8	9
35	R:R:L45	R:R:L62	12.6873	2.77	No	No	0	8	8
36	R:R:G49	R:R:L62	11.141	1.71	No	No	0	7	8
37	R:R:I116	R:R:Y435	58.6061	7.25	No	Yes	2	9	9
38	R:R:I116	R:R:W60	64.9866	3.52	No	Yes	0	9	8
39	R:R:D119	R:R:W60	53.297	13.4	No	Yes	0	9	8
40	R:R:D119	R:R:R134	37.5281	11.91	No	Yes	4	9	9
41	R:R:N57	R:R:R134	22.6833	3.62	No	Yes	0	8	9
42	R:R:N57	R:R:T55	21.2952	2.92	No	No	0	8	9
43	R:R:T55	R:R:T58	18.5192	4.71	No	No	0	9	8
44	R:R:M52	R:R:T58	15.8242	3.01	Yes	No	0	9	8
45	R:R:C143	R:R:W60	12.4554	3.92	No	Yes	0	8	8
46	R:R:C143	R:R:H63	11.395	17.69	No	No	0	8	8
47	R:R:C71	R:R:N105	12.8972	6.3	No	No	0	8	9
48	R:R:A67	R:R:N105	10.4672	4.69	No	No	0	9	9
49	R:R:H63	R:R:W147	10.3973	7.41	No	Yes	0	8	9
50	R:R:K96	R:R:R161	33.1173	3.71	No	No	0	8	8
51	R:R:F158	R:R:K96	25.5845	9.93	No	No	0	8	8
52	R:R:F158	R:R:S100	17.9853	2.64	No	No	0	8	8
53	R:R:S100	R:R:V157	15.4376	3.23	No	No	0	8	9
54	R:R:F386	R:R:W390	23.0257	6.01	Yes	Yes	1	9	9
55	R:R:F386	R:R:M352	20.1613	4.98	Yes	No	0	9	8
56	R:R:M352	R:R:S117	19.8152	6.13	No	No	0	8	9
57	R:R:C355	R:R:S117	31.0114	6.89	No	No	0	9	9
58	R:R:S117	R:R:Y356	21.4793	5.09	No	Yes	0	9	9
59	R:R:D119	R:R:V123	14.5392	4.38	No	No	4	9	5
60	R:R:C121	R:R:C355	28.3384	7.28	No	No	0	9	9
61	R:R:C121	R:R:F125	25.4446	4.19	No	No	0	9	6
62	R:R:C130	R:R:V123	13.1181	5.12	Yes	No	4	7	5
63	R:R:C130	R:R:R134	13.9465	4.18	Yes	Yes	4	7	9
64	R:R:F125	R:R:V124	21.0449	3.93	No	No	0	6	9
65	R:R:C130	R:R:W129	15.1099	2.61	Yes	No	0	7	6
66	R:R:I336	R:R:V157	12.8824	3.07	No	No	0	7	9
67	R:R:I336	R:R:P156	10.3199	5.08	No	No	0	7	9
68	R:R:R362	R:R:V124	19.5575	2.62	No	No	0	7	9
69	R:R:F368	R:R:R362	16.6931	4.28	No	No	0	5	7
70	R:R:F368	R:R:M363	12.2823	9.95	No	Yes	0	5	7
71	R:R:D417	R:R:F396	15.0952	3.58	Yes	No	0	8	4
72	R:R:F396	R:R:L413	11.6932	6.09	No	Yes	0	4	7
73	L:L:?9	L:L:L8	73.6387	4.22	Yes	Yes	1	0	0
74	L:L:?9	R:R:Y393	41.8946	7.15	Yes	Yes	1	0	9
75	R:R:M106	R:R:W390	37.1415	5.82	No	Yes	1	9	9
76	R:R:D68	R:R:L64	12.7425	5.43	Yes	Yes	2	9	9
77	R:R:L64	R:R:Y435	13.1402	3.52	Yes	Yes	2	9	9
78	R:R:R120	R:R:Y356	11.8405	11.32	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F3	R:R:G173	4.52	0	No	No	0	1	0	1
L:L:K4	R:R:L333	5.64	0	No	Yes	0	3	0	1
L:L:P5	R:R:R171	10.09	0	No	No	0	1	0	1
L:L:M6	R:R:Y174	11.97	0	Yes	No	0	7	0	1
L:L:M6	R:R:L333	4.24	0	Yes	Yes	0	3	0	1
L:L:P7	R:R:D417	6.44	1	No	Yes	0	8	0	1
L:L:P7	R:R:I421	3.39	1	No	Yes	0	4	0	1
L:L:L8	R:R:H81	9	1	Yes	Yes	0	7	0	1
L:L:L8	R:R:W88	5.69	1	Yes	Yes	0	9	0	1
L:L:L8	R:R:I98	4.28	1	Yes	Yes	0	8	0	1
L:L:L8	R:R:P99	6.57	1	Yes	No	0	8	0	1
L:L:L8	R:R:I102	4.28	1	Yes	Yes	0	8	0	1
L:L:?9	R:R:I102	4.36	1	Yes	Yes	0	8	0	1
L:L:?9	R:R:M106	4.31	1	Yes	No	0	9	0	1
L:L:?9	R:R:Y393	7.15	1	Yes	Yes	0	9	0	1
L:L:?9	R:R:I421	5.81	1	Yes	Yes	0	4	0	1
L:L:R10	R:R:R340	6.4	1	Yes	Yes	0	9	0	1
L:L:R10	R:R:Y393	14.4	1	Yes	Yes	0	9	0	1
L:L:R10	R:R:D417	17.87	1	Yes	Yes	0	8	0	1
L:L:R10	R:R:I421	7.52	1	Yes	Yes	0	4	0	1
R:R:I102	R:R:S74	4.64	1	Yes	No	8	9	1	2
R:R:F77	R:R:I98	10.05	0	No	Yes	8	8	2	1
R:R:G86	R:R:H81	3.18	1	No	Yes	7	7	2	1
R:R:H81	R:R:W88	7.41	1	Yes	Yes	7	9	1	1
R:R:H81	R:R:R171	5.64	1	Yes	No	7	1	1	1
R:R:G86	R:R:R171	3	1	No	No	7	1	2	1
R:R:P89	R:R:W88	5.4	1	No	Yes	8	9	2	1
R:R:W88	R:R:Y90	7.72	1	Yes	No	9	7	1	2
R:R:C95	R:R:W88	13.06	1	No	Yes	9	9	2	1
R:R:I98	R:R:W88	4.7	1	Yes	Yes	8	9	1	1
R:R:P89	R:R:Y90	4.17	1	No	No	8	7	2	2
R:R:I98	R:R:P99	11.85	1	Yes	No	8	8	1	1
R:R:I102	R:R:I98	5.89	1	Yes	Yes	8	8	1	1
R:R:P99	R:R:R161	5.76	1	No	No	8	8	1	2
R:R:R340	R:R:V103	3.92	1	Yes	No	9	5	1	2
R:R:M106	R:R:W390	5.82	1	No	Yes	9	9	1	2
R:R:M106	R:R:Y393	3.59	1	No	Yes	9	9	1	1
R:R:F107	R:R:M153	7.46	1	Yes	Yes	8	8	2	2
R:R:F107	R:R:R340	7.48	1	Yes	Yes	8	9	2	1
R:R:F107	R:R:Y393	5.16	1	Yes	Yes	8	9	2	1
R:R:M153	R:R:R340	3.72	1	Yes	Yes	8	9	2	1
R:R:R161	R:R:Y174	13.38	0	No	No	8	7	2	1
R:R:L333	R:R:T337	4.42	5	Yes	No	3	7	1	2
R:R:L333	R:R:L401	4.15	5	Yes	No	3	7	1	2
R:R:L401	R:R:T337	5.9	5	No	No	7	7	2	2
R:R:R340	R:R:Y393	6.17	1	Yes	Yes	9	9	1	1
R:R:W390	R:R:Y393	4.82	1	Yes	Yes	9	9	2	1
R:R:H394	R:R:W390	4.23	1	Yes	Yes	9	9	2	2
R:R:A424	R:R:W390	7.78	1	No	Yes	9	9	2	2
R:R:H394	R:R:Y393	9.8	1	Yes	Yes	9	9	2	1
R:R:A424	R:R:Y393	4	1	No	Yes	9	9	2	1
R:R:D417	R:R:F396	3.58	1	Yes	No	8	4	1	2
R:R:D417	R:R:I421	5.6	1	Yes	Yes	8	4	1	1
R:R:I101	R:R:I98	2.94	0	No	Yes	5	8	2	1
R:R:G173	R:R:Y174	2.9	0	No	No	1	7	1	1
L:L:F3	R:R:F164	2.14	0	No	No	0	3	0	1
L:L:R10	R:R:G397	1.5	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8I95_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	271
Number of Links	314
Number of Hubs	43
Number of Links mediated by Hubs	158
Number of Communities	7
Number of Nodes involved in Communities	56
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	61447
Length Of Smallest Path	3
Average Path Length	13.9421
Length of Longest Path	32
Minimum Path Strength	1.4
Average Path Strength	5.9042
Maximum Path Strength	16.135
Minimum Path Correlation	0.7
Average Path Correlation	0.925563
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.7371
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.2166
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • complement component C3a receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • G protein-coupled receptor activity • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • calcium-mediated signaling • intracellular vesicle • endomembrane system • specific granule membrane • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule • azurophil granule • primary lysosome • azurophil granule membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Ala
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8I95_nogp_Chain_R P W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	10.1016/j.cell.2023.09.020
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	10.1038/s41589-023-01339-w
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	10.1038/s41589-023-01339-w

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