Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:M6 5.82400
2L:L:L8 5.67333610
3L:L:?9 5.33833610
4L:L:R10 8.22714710
5R:R:L30 5.6875406
6R:R:N41 6.2875409
7R:R:V44 3.5275409
8R:R:V47 3.114538
9R:R:M52 5.5575439
10R:R:W60 5.945608
11R:R:L64 4.596529
12R:R:D68 6.38529
13R:R:L75 5.1475409
14R:R:H81 6.3075417
15R:R:L84 2.275408
16R:R:W88 7.33619
17R:R:I98 6.61833618
18R:R:I102 4.7925418
19R:R:F107 5.7775418
20R:R:F111 4.2125418
21R:R:C130 4.1675447
22R:R:R134 6.82549
23R:R:W147 4.492509
24R:R:M153 5.49418
25R:R:L333 4.6125453
26R:R:R340 5.538519
27R:R:P348 3.1825409
28R:R:Y356 6.118509
29R:R:M363 6.12407
30R:R:V378 3.3625408
31R:R:V382 3.325408
32R:R:F386 4.97419
33R:R:W390 6.45719
34R:R:Y393 6.88625819
35R:R:H394 8.4325419
36R:R:T403 2.75462
37R:R:L413 4.272567
38R:R:D417 8.3725418
39R:R:I421 5.58414
40R:R:N431 7.978529
41R:R:Y435 6.235629
42R:R:F442 4.665409
43R:R:K445 8.2875437
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:M6 R:R:Y174 16.748311.97YesNo007
2R:R:R161 R:R:Y174 14.126913.38NoNo087
3R:R:P99 R:R:R161 23.45645.76NoNo088
4L:L:L8 R:R:P99 22.99996.57YesNo108
5L:L:M6 L:L:R10 23.40123.72YesYes000
6L:L:R10 R:R:D417 13.390517.87YesYes108
7L:L:L8 R:R:W88 42.09715.69YesYes109
8L:L:?9 R:R:M106 36.79914.31YesNo109
9L:L:R10 R:R:Y393 30.91214.4YesYes109
10R:R:W390 R:R:Y393 75.67844.82YesYes199
11R:R:N427 R:R:W390 1007.91NoYes099
12R:R:N427 R:R:N431 99.182710.9NoYes099
13R:R:D68 R:R:N431 60.21878.08YesYes299
14R:R:D68 R:R:S428 51.40094.42YesNo099
15R:R:C71 R:R:S428 49.91356.89NoNo089
16R:R:C71 R:R:S425 47.76333.44NoNo088
17R:R:L75 R:R:S425 46.08083YesNo098
18R:R:L30 R:R:L75 38.08038.3YesYes069
19R:R:A422 R:R:L30 28.76923.15NoYes086
20R:R:A422 R:R:S26 24.03813.42NoNo088
21R:R:S26 R:R:V419 22.63913.23NoNo085
22R:R:V419 R:R:W416 21.15177.36NoNo057
23R:R:P22 R:R:W416 19.56859.46NoNo047
24R:R:P89 R:R:W88 28.96065.4NoYes189
25R:R:L84 R:R:P89 27.36283.28YesNo088
26R:R:A83 R:R:L84 14.87061.58NoYes058
27R:R:A83 R:R:M27 13.03711.61NoNo056
28R:R:I24 R:R:M27 11.19621.46NoNo076
29R:R:N431 R:R:Y435 61.52575.81YesYes299
30R:R:V382 R:R:Y435 16.0236.31YesYes089
31R:R:V381 R:R:V382 10.98271.6NoYes078
32R:R:D68 R:R:N41 30.0328.08YesYes099
33R:R:N41 R:R:T65 22.18992.92YesNo099
34R:R:L45 R:R:T65 14.27412.95NoNo089
35R:R:L45 R:R:L62 12.68732.77NoNo088
36R:R:G49 R:R:L62 11.1411.71NoNo078
37R:R:I116 R:R:Y435 58.60617.25NoYes299
38R:R:I116 R:R:W60 64.98663.52NoYes098
39R:R:D119 R:R:W60 53.29713.4NoYes098
40R:R:D119 R:R:R134 37.528111.91NoYes499
41R:R:N57 R:R:R134 22.68333.62NoYes089
42R:R:N57 R:R:T55 21.29522.92NoNo089
43R:R:T55 R:R:T58 18.51924.71NoNo098
44R:R:M52 R:R:T58 15.82423.01YesNo098
45R:R:C143 R:R:W60 12.45543.92NoYes088
46R:R:C143 R:R:H63 11.39517.69NoNo088
47R:R:C71 R:R:N105 12.89726.3NoNo089
48R:R:A67 R:R:N105 10.46724.69NoNo099
49R:R:H63 R:R:W147 10.39737.41NoYes089
50R:R:K96 R:R:R161 33.11733.71NoNo088
51R:R:F158 R:R:K96 25.58459.93NoNo088
52R:R:F158 R:R:S100 17.98532.64NoNo088
53R:R:S100 R:R:V157 15.43763.23NoNo089
54R:R:F386 R:R:W390 23.02576.01YesYes199
55R:R:F386 R:R:M352 20.16134.98YesNo098
56R:R:M352 R:R:S117 19.81526.13NoNo089
57R:R:C355 R:R:S117 31.01146.89NoNo099
58R:R:S117 R:R:Y356 21.47935.09NoYes099
59R:R:D119 R:R:V123 14.53924.38NoNo495
60R:R:C121 R:R:C355 28.33847.28NoNo099
61R:R:C121 R:R:F125 25.44464.19NoNo096
62R:R:C130 R:R:V123 13.11815.12YesNo475
63R:R:C130 R:R:R134 13.94654.18YesYes479
64R:R:F125 R:R:V124 21.04493.93NoNo069
65R:R:C130 R:R:W129 15.10992.61YesNo076
66R:R:I336 R:R:V157 12.88243.07NoNo079
67R:R:I336 R:R:P156 10.31995.08NoNo079
68R:R:R362 R:R:V124 19.55752.62NoNo079
69R:R:F368 R:R:R362 16.69314.28NoNo057
70R:R:F368 R:R:M363 12.28239.95NoYes057
71R:R:D417 R:R:F396 15.09523.58YesNo084
72R:R:F396 R:R:L413 11.69326.09NoYes047
73L:L:?9 L:L:L8 73.63874.22YesYes100
74L:L:?9 R:R:Y393 41.89467.15YesYes109
75R:R:M106 R:R:W390 37.14155.82NoYes199
76R:R:D68 R:R:L64 12.74255.43YesYes299
77R:R:L64 R:R:Y435 13.14023.52YesYes299
78R:R:R120 R:R:Y356 11.840511.32NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F3 R:R:G173 4.52 0 No No 0 1 0 1
L:L:K4 R:R:L333 5.64 0 No Yes 0 3 0 1
L:L:P5 R:R:R171 10.09 0 No No 0 1 0 1
L:L:M6 R:R:Y174 11.97 0 Yes No 0 7 0 1
L:L:M6 R:R:L333 4.24 0 Yes Yes 0 3 0 1
L:L:P7 R:R:D417 6.44 1 No Yes 0 8 0 1
L:L:P7 R:R:I421 3.39 1 No Yes 0 4 0 1
L:L:L8 R:R:H81 9 1 Yes Yes 0 7 0 1
L:L:L8 R:R:W88 5.69 1 Yes Yes 0 9 0 1
L:L:L8 R:R:I98 4.28 1 Yes Yes 0 8 0 1
L:L:L8 R:R:P99 6.57 1 Yes No 0 8 0 1
L:L:L8 R:R:I102 4.28 1 Yes Yes 0 8 0 1
L:L:?9 R:R:I102 4.36 1 Yes Yes 0 8 0 1
L:L:?9 R:R:M106 4.31 1 Yes No 0 9 0 1
L:L:?9 R:R:Y393 7.15 1 Yes Yes 0 9 0 1
L:L:?9 R:R:I421 5.81 1 Yes Yes 0 4 0 1
L:L:R10 R:R:R340 6.4 1 Yes Yes 0 9 0 1
L:L:R10 R:R:Y393 14.4 1 Yes Yes 0 9 0 1
L:L:R10 R:R:D417 17.87 1 Yes Yes 0 8 0 1
L:L:R10 R:R:I421 7.52 1 Yes Yes 0 4 0 1
R:R:I102 R:R:S74 4.64 1 Yes No 8 9 1 2
R:R:F77 R:R:I98 10.05 0 No Yes 8 8 2 1
R:R:G86 R:R:H81 3.18 1 No Yes 7 7 2 1
R:R:H81 R:R:W88 7.41 1 Yes Yes 7 9 1 1
R:R:H81 R:R:R171 5.64 1 Yes No 7 1 1 1
R:R:G86 R:R:R171 3 1 No No 7 1 2 1
R:R:P89 R:R:W88 5.4 1 No Yes 8 9 2 1
R:R:W88 R:R:Y90 7.72 1 Yes No 9 7 1 2
R:R:C95 R:R:W88 13.06 1 No Yes 9 9 2 1
R:R:I98 R:R:W88 4.7 1 Yes Yes 8 9 1 1
R:R:P89 R:R:Y90 4.17 1 No No 8 7 2 2
R:R:I98 R:R:P99 11.85 1 Yes No 8 8 1 1
R:R:I102 R:R:I98 5.89 1 Yes Yes 8 8 1 1
R:R:P99 R:R:R161 5.76 1 No No 8 8 1 2
R:R:R340 R:R:V103 3.92 1 Yes No 9 5 1 2
R:R:M106 R:R:W390 5.82 1 No Yes 9 9 1 2
R:R:M106 R:R:Y393 3.59 1 No Yes 9 9 1 1
R:R:F107 R:R:M153 7.46 1 Yes Yes 8 8 2 2
R:R:F107 R:R:R340 7.48 1 Yes Yes 8 9 2 1
R:R:F107 R:R:Y393 5.16 1 Yes Yes 8 9 2 1
R:R:M153 R:R:R340 3.72 1 Yes Yes 8 9 2 1
R:R:R161 R:R:Y174 13.38 0 No No 8 7 2 1
R:R:L333 R:R:T337 4.42 5 Yes No 3 7 1 2
R:R:L333 R:R:L401 4.15 5 Yes No 3 7 1 2
R:R:L401 R:R:T337 5.9 5 No No 7 7 2 2
R:R:R340 R:R:Y393 6.17 1 Yes Yes 9 9 1 1
R:R:W390 R:R:Y393 4.82 1 Yes Yes 9 9 2 1
R:R:H394 R:R:W390 4.23 1 Yes Yes 9 9 2 2
R:R:A424 R:R:W390 7.78 1 No Yes 9 9 2 2
R:R:H394 R:R:Y393 9.8 1 Yes Yes 9 9 2 1
R:R:A424 R:R:Y393 4 1 No Yes 9 9 2 1
R:R:D417 R:R:F396 3.58 1 Yes No 8 4 1 2
R:R:D417 R:R:I421 5.6 1 Yes Yes 8 4 1 1
R:R:I101 R:R:I98 2.94 0 No Yes 5 8 2 1
R:R:G173 R:R:Y174 2.9 0 No No 1 7 1 1
L:L:F3 R:R:F164 2.14 0 No No 0 3 0 1
L:L:R10 R:R:G397 1.5 1 Yes No 0 8 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8I95_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3
Number of Linked Nodes 271
Number of Links 314
Number of Hubs 43
Number of Links mediated by Hubs 158
Number of Communities 7
Number of Nodes involved in Communities 56
Number of Links involved in Communities 84
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 61447
Length Of Smallest Path 3
Average Path Length 13.9421
Length of Longest Path 32
Minimum Path Strength 1.4
Average Path Strength 5.9042
Maximum Path Strength 16.135
Minimum Path Correlation 0.7
Average Path Correlation 0.925558
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 48.7165
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.2166
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDAL
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeDAL
NameD-Alanine
SynonymsD-Alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8I95_nogp_Chain_R
PWNEPPVIL SMVILSLTF LLGLPGNGL VLWVAGLKM QRTVNTIWF 
LHLTLADLL CCLSLPFSL AHLALQGQW PYGRFLCKL IPSIIVLNM 
FASVFLLTA ISLDRCLVV FKPIWCQNH RNVGMACSI CGCIWVVAF 
VMCIPVFVY REIFTTDNH NRCGYTPLV AITITRLVV GFLLPSVIM 
IACYSFIVF RMQRGRFAK SQSKTFRVA VVVVAVFLV CWTPYHIFG 
VLSLLTDPE TPLGKTLMS WDHVCIALA SANSCFNPF LYALLGKDF 
RKKARQSIQ G


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KVP (No Gprot) APeptideComplement PeptideC3aBHomo sapiensSB290157-2.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP67-3.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZ8 (No Gprot) APeptideComplement PeptideC3aBMus musculusEP67-3.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9KZK (No Gprot) APeptideComplement PeptideC3aBMus musculusC3a (fragment)-3.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9L0H (No Gprot) APeptideComplement PeptideC3aBMus musculusJR14a-3.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9UMJ (No Gprot) APeptideComplement PeptideC3aBMus musculusEP54-3.382025-11-2610.1101/2025.05.26.656101
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWF (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KUT (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-3.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV6 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-2.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KV8 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-3.172025-11-2610.1101/2025.05.26.656101




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