Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 3.855455
2A:A:L37 8.6675419
3A:A:I49 5.205427
4A:A:Q52 4.425429
5A:A:F191 9.1575455
6A:A:L194 6.555454
7A:A:K197 7.92416
8A:A:M198 3.7825407
9A:A:F199 5.982515
10A:A:Q204 6.6025419
11A:A:K210 5.85619
12A:A:W211 6.20333619
13A:A:H213 6.974118
14A:A:F215 6.93619
15A:A:I221 6.525418
16A:A:F223 7.24509
17A:A:V225 4.845407
18A:A:Y230 5.908336138
19A:A:F250 8.08409
20A:A:W258 9.201676115
21A:A:F259 5.6325419
22A:A:I265 3.7875428
23A:A:F267 4.308529
24A:A:N269 5.53429
25A:A:K270 5.66254199
26A:A:F274 7.0785139
27A:A:Y287 5.94833687
28A:A:Y290 9.8875487
29A:A:Y296 4.805404
30A:A:Y302 10.1475486
31A:A:N311 5.044208
32A:A:Y320 7.35857727
33A:A:H322 8.1475429
34A:A:F323 3.5275404
35A:A:T324 5.8425429
36A:A:F334 8.3025423
37A:A:F336 5.84667658
38A:A:V339 3.2975458
39A:A:I344 3.95456
40A:A:G352 1.8175408
41A:A:F354 9.1225405
42B:B:L14 3.8375408
43B:B:V40 3.055163
44B:B:R48 6.73447
45B:B:H54 7.171437109
46B:B:Y59 10.5465118
47B:B:W63 7.21667647
48B:B:S74 5.934109
49B:B:D76 5.59254109
50B:B:I80 9.22754108
51B:B:W82 12.64254109
52B:B:N88 5.9125407
53B:B:K89 6.588336109
54B:B:L95 6.09478
55B:B:W99 7.84719
56B:B:Y105 3.91506
57B:B:Y111 5.2775404
58B:B:Y124 6.382576
59B:B:E130 5.5725403
60B:B:V133 4.65474
61B:B:Y145 7.06833618
62B:B:L146 4.42517
63B:B:F151 5.248509
64B:B:L152 3.656503
65B:B:S161 6.325419
66B:B:W169 11.4175418
67B:B:F180 7.665127
68B:B:H183 6.6754129
69B:B:D186 6.235419
70B:B:V187 5.04754129
71B:B:M188 5.2075418
72B:B:L190 3.2405
73B:B:F199 5.9654129
74B:B:V200 6.9275436
75B:B:C204 5.9125417
76B:B:W211 8.8345128
77B:B:R219 8.344175
78B:B:F222 7.975438
79B:B:H225 11.68539
80B:B:D228 7.2225419
81B:B:I229 5.07437
82B:B:I232 5.55438
83B:B:F234 5.17333635
84B:B:F235 4.843336146
85B:B:P236 5.66754147
86B:B:F241 5.49833636
87B:B:D246 6.545419
88B:B:R251 6.77714738
89B:B:F253 6.67667636
90B:B:D254 3.7525409
91B:B:R256 6.335409
92B:B:M262 5.8454234
93B:B:Y264 5.4285235
94B:B:F278 6.5525147
95B:B:L284 4.0745165
96B:B:Y289 7.506507
97B:B:D290 7.465406
98B:B:L300 3.955226
99B:B:H311 6.995499
100B:B:L318 4.4725406
101B:B:T329 5.5325408
102B:B:W332 10.12867119
103B:B:D333 9.415499
104B:B:W339 7.7865249
105B:B:N340 7.96449
106R:R:L38 4.6175467
107R:R:N41 5.30333669
108R:R:W46 5.5675496
109R:R:W60 5.11833608
110R:R:H63 7.2875408
111R:R:D68 7.02167669
112R:R:L75 5.9654279
113R:R:W88 9.65254159
114R:R:Y90 6.04254157
115R:R:C95 4.90754159
116R:R:K96 7.4354288
117R:R:I98 4.105408
118R:R:I102 4.5625408
119R:R:F107 7.1575408
120R:R:F111 4.6875408
121R:R:R120 7.76409
122R:R:R134 4.5175409
123R:R:R161 8.125408
124R:R:H169 12.06754183
125R:R:R171 7.1454181
126R:R:P348 3.5925409
127R:R:Y356 4.1275409
128R:R:F368 9.3925425
129R:R:W390 9.135409
130R:R:T403 3.795402
131R:R:W416 3.65607
132R:R:I421 3.465404
133R:R:Y435 4.748569
134R:R:F442 4.466509
135R:R:K445 4.2625497
136G:G:V16 1.8825407
137G:G:Y40 8.60754146
138G:G:D48 6.1509
139G:G:L51 3.1225166
140G:G:N59 5.158549
141G:G:P60 7.0275449
142G:G:F61 5.46848
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I19 B:B:K89 57.48398.72NoYes099
2A:A:I19 A:A:R15 56.87816.26NoNo095
3A:A:R15 B:B:H91 56.76963.39NoNo055
4B:B:H54 B:B:I80 29.96713.26YesYes1098
5B:B:I80 B:B:K89 29.73364.36YesYes1089
6B:B:H54 B:B:W82 30.53573.17YesYes1099
7B:B:K89 B:B:W82 33.060111.6YesYes1099
8B:B:H54 B:B:I58 60.48747.95YesNo1099
9B:B:I58 B:B:S316 61.40983.1NoNo099
10B:B:S316 B:B:W332 69.81414.94NoYes099
11B:B:N313 B:B:W332 88.45496.78NoYes079
12B:B:N313 B:B:S331 93.60772.98NoNo079
13B:B:D333 B:B:S331 90.654810.31YesNo999
14B:B:D312 B:B:D333 1006.65NoYes959
15B:B:D312 R:R:K445 99.58835.53NoYes957
16R:R:K445 R:R:V47 98.62623.04YesNo078
17R:R:F442 R:R:V47 97.7556.55YesNo098
18R:R:F442 R:R:V44 96.69839.18YesNo099
19R:R:T65 R:R:V44 96.5217.93NoNo099
20R:R:N41 R:R:T65 96.16535.85YesNo099
21R:R:D68 R:R:N41 91.72756.73YesYes699
22R:R:D68 R:R:L64 82.89359.5YesNo699
23R:R:L64 R:R:Y435 82.4383.52NoYes699
24R:R:R120 R:R:Y435 80.56878.23YesYes099
25R:R:I116 R:R:R120 78.05037.52NoYes099
26R:R:I116 R:R:W60 77.83827.05NoYes098
27R:R:I142 R:R:W60 42.67144.7NoYes058
28B:B:W332 B:B:Y59 37.130518.33YesYes1198
29B:B:Q75 B:B:Y59 37.307813.53NoYes098
30B:B:Q75 B:B:W99 37.52715.48NoYes099
31R:R:D119 R:R:W60 36.76013.35NoYes098
32R:R:D119 R:R:R134 36.48983.57NoYes099
33A:A:N347 R:R:R134 35.99013.62NoYes089
34A:A:I343 A:A:N347 35.44634.25NoNo078
35A:A:I343 A:A:V339 34.90113.07NoYes078
36A:A:L36 A:A:V339 16.4332.98NoYes578
37A:A:L36 A:A:M198 16.26894.24NoYes077
38A:A:N256 A:A:W258 10.71049.04NoYes085
39A:A:F259 A:A:N256 10.55194.83YesNo098
40A:A:F259 A:A:I221 10.15458.79YesYes198
41A:A:F215 B:B:W99 21.742911.02YesYes199
42A:A:F223 A:A:L249 30.19484.87YesNo099
43A:A:F215 A:A:W211 21.45425.01YesYes199
44A:A:R208 A:A:W211 21.36876NoYes099
45A:A:L249 A:A:R208 21.06334.86NoNo099
46B:B:L117 B:B:W99 21.119110.25NoYes099
47A:A:W211 B:B:L117 20.99364.56YesNo099
48A:A:F223 A:A:V225 10.77793.93YesYes097
49A:A:I222 A:A:M198 14.05172.92NoYes077
50A:A:F267 A:A:I222 13.75845.02YesNo097
51A:A:F336 A:A:L194 16.04464.87YesYes584
52A:A:W211 B:B:Y145 20.01757.72YesYes198
53A:A:F223 A:A:L266 10.08544.87YesNo099
54B:B:R314 B:B:W332 20.45715.99NoYes1189
55A:A:F336 A:A:T340 11.26437.78YesNo586
56A:A:I344 A:A:T340 10.06523.04YesNo566
57B:B:H91 B:B:V90 28.35076.92NoNo055
58B:B:I81 B:B:V90 28.10256.14NoNo075
59B:B:I81 B:B:V71 27.85533.07NoNo078
60B:B:V71 B:B:Y105 27.3993.79NoYes086
61B:B:H62 B:B:Y105 60.91643.27NoYes066
62B:B:H62 B:B:R150 60.45445.64NoNo066
63B:B:C148 B:B:R150 59.9925.57NoNo066
64B:B:C148 B:B:L190 59.52923.17NoYes065
65B:B:F199 B:B:L190 52.35213.65YesYes095
66B:B:F199 B:B:W211 46.65169.02YesYes1298
67B:B:C218 B:B:W211 45.01457.84NoYes058
68B:B:C218 B:B:K209 44.06684.85NoNo056
69B:B:K209 B:B:T221 43.59249.01NoNo067
70B:B:T221 G:G:E22 43.11764.23NoNo079
71G:G:E22 G:G:I25 42.64262.73NoNo092
72B:B:Q220 G:G:I25 42.16724.12NoNo072
73B:B:D258 B:B:Q220 13.511311.75NoNo077
74B:B:D258 B:B:R22 12.014213.1NoNo2176
75B:B:I18 B:B:R22 11.52546.26NoNo076
76B:B:I18 G:G:L19 10.53042.85NoNo079
77B:B:H91 B:B:V133 28.66874.15NoYes054
78B:B:L126 B:B:V133 35.52012.98NoYes054
79B:B:L126 B:B:V112 35.27175.96NoNo058
80B:B:V112 B:B:Y105 35.02363.79NoYes086
81B:B:F222 B:B:Q220 28.71655.86YesNo087
82B:B:D290 B:B:R314 22.292719.06YesNo068
83B:B:C271 B:B:D290 25.32043.11NoYes056
84B:B:C271 B:B:Y289 30.53354.03NoYes057
85B:B:W297 B:B:Y289 24.95939.65NoYes087
86B:B:W297 B:B:Y264 24.2567.72NoYes085
87B:B:L285 B:B:Y264 20.72943.52NoYes065
88B:B:F278 B:B:L285 19.964613.4YesNo076
89B:B:N237 G:G:Y40 14.917916.28NoYes056
90B:B:N237 B:B:N239 14.13588.17NoNo052
91B:B:N239 B:B:R256 13.35347.23NoYes029
92B:B:H311 B:B:T329 12.27588.21YesYes098
93B:B:C317 B:B:S316 10.04773.44NoNo079
94B:B:S97 B:B:W99 10.90783.71NoYes089
95B:B:E138 B:B:I120 10.19924.1NoNo066
96B:B:D118 B:B:I120 10.61148.4NoNo096
97B:B:G162 B:B:Y145 16.29245.79NoYes198
98B:B:G162 B:B:S161 16.01693.71NoYes199
99B:B:H142 B:B:S161 12.1269.76NoYes199
100B:B:H142 B:B:W169 11.847612.7NoYes198
101B:B:L139 B:B:W169 10.553115.94NoYes098
102B:B:F222 B:B:F241 18.82077.5YesYes386
103R:R:I142 R:R:I146 40.02452.94NoNo058
104R:R:F111 R:R:I146 39.75795.02YesNo088
105R:R:F107 R:R:F111 38.95619.65YesYes088
106R:R:F107 R:R:R340 34.62796.41YesNo089
107R:R:R340 R:R:Y393 34.35456.17NoNo099
108R:R:I421 R:R:Y393 26.25323.63YesNo049
109R:R:I421 R:R:S78 25.14073.1YesNo048
110R:R:I102 R:R:S78 24.85569.29YesNo088
111R:R:I102 R:R:I98 23.71192.94YesYes088
112R:R:I98 R:R:P99 11.11885.08YesNo088
113R:R:H81 R:R:P99 10.82456.1NoNo078
114R:R:I98 R:R:L94 12.02037.14YesNo088
115R:R:L94 R:R:W88 10.8249.11NoYes1589
116R:R:C95 R:R:W88 10.54715.22YesYes1599
117R:R:C95 R:R:H81 10.52922.95YesNo1597
118R:R:C95 R:R:R161 19.88344.18YesYes098
119R:R:K96 R:R:R161 10.89173.71YesYes088
120B:B:D118 B:B:S97 10.75464.42NoNo098
121B:B:D333 B:B:H311 10.1937.56YesYes999
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HK3
Class A
SubFamily Peptide
Type Complement peptide
SubType C3A
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.2
Date 2023-05-10
D.O.I. 10.1038/s41589-023-01339-w
Net Summary
Imin 2.95
Number of Linked Nodes 854
Number of Links 987
Number of Hubs 142
Number of Links mediated by Hubs 538
Number of Communities 28
Number of Nodes involved in Communities 202
Number of Links involved in Communities 273
Path Summary
Number Of Nodes in MetaPath 122
Number Of Links MetaPath 121
Number of Shortest Paths 994491
Length Of Smallest Path 3
Average Path Length 33.6144
Length of Longest Path 77
Minimum Path Strength 1.21
Average Path Strength 6.19724
Maximum Path Strength 19.06
Minimum Path Correlation 0.7
Average Path Correlation 0.97732
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 44.0153
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.1151
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HK3_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLAEDEE MNRMHESMK LFDSICNNK WFTDTSIIL 
FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN 
KRKDTKEIY THFTCSTDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8HK3_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8HK3_Chain_R
WNEPPVILS MVILSLTFL LGLPGNGLV LWVAGLKMQ RTVNTIWFL 
HLTLADLLC CLSLPFSLA HLALQGQWP YGRFLCKLI PSIIVLNMF 
ASVFLLTAI SLDRCLVVF KPIWCQNHR NVGMACSIC GCIWVVAFV 
MCIPVFVYR EIFTTDNHN RCGYKFPTP LVAITITRL VVGFLLPSV 
IMIACYSFI VFRMQRGRF AKSQSKTFR VAVVVVAVF LVCWTPYHI 
FGVLSLLTD PETPLGKTL MSWDHVCIA LASANSCFN PFLYALLGK 
DFRKKARQS IQGIL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8HK3_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement peptideC3aBHomo sapiensC3a anaphylatoxin-Gi1/&β;1/&γ;22.92023-05-1010.1038/s41589-023-01339-w
8I95APeptideComplement peptideC3aBHomo sapiensEP54-Go/&β;1/&γ;22.882023-10-1810.1016/j.cell.2023.09.020
8I97APeptideComplement peptideC3aBHomo sapiens--Go/&β;1/&γ;23.12023-10-1810.1016/j.cell.2023.09.020
8I9AAPeptideComplement peptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.572023-10-1810.1016/j.cell.2023.09.020
8I9LAPeptideComplement peptideC3aBHomo sapiensC3a anaphylatoxin-Go/&β;1/&γ;23.182023-10-1810.1016/j.cell.2023.09.020
8I9SAPeptideComplement peptideC3aBHomo sapiens--Go/&β;1/&γ;23.262023-10-1810.1016/j.cell.2023.09.020
8IA8APeptideComplement peptideC3aBHomo sapiensE7 peptide-Gi1/&β;1/&γ;22.862023-05-24To be published
8J6DAPeptideComplement peptideC3aBHomo sapiensEP141-Go/&β;1/&γ;23.12023-10-1810.1016/j.cell.2023.09.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HK3.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.