psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S1	L:L:V2	3.23	Yes	No	2	0	0
2	L:L:L4	L:L:S1	4.5	Yes	Yes	2	0	0
3	L:L:R8	L:L:S1	3.95	Yes	Yes	2	0	0
4	L:L:E29	L:L:S1	4.31	No	Yes	0	0	0
5	L:L:L4	L:L:V2	4.47	Yes	No	2	0	0
6	L:L:E6	L:L:Q3	7.65	No	Yes	0	0	0
7	L:L:K7	L:L:Q3	4.07	No	Yes	0	0	0
8	L:L:Q3	R:R:T165	2.83	Yes	No	0	0	4
9	L:L:Q3	R:R:D167	6.53	Yes	No	0	0	3
10	L:L:L4	L:L:L63	2.77	Yes	Yes	0	0	0
11	L:L:H67	L:L:L4	6.43	Yes	Yes	0	0	0
12	L:L:R8	L:L:T5	3.88	Yes	No	0	0	0
13	L:L:K7	L:L:L63	2.82	No	Yes	0	0	0
14	L:L:M27	L:L:R8	6.2	Yes	Yes	2	0	0
15	L:L:I60	L:L:R8	2.51	No	Yes	2	0	0
16	L:L:K11	L:L:M27	4.32	Yes	Yes	0	0	0
17	L:L:D55	L:L:K11	2.77	No	Yes	0	0	0
18	L:L:K11	L:L:Y59	15.53	Yes	No	0	0	0
19	L:L:K17	L:L:V12	6.07	No	No	0	0	0
20	L:L:P16	L:L:Y15	9.74	No	No	0	0	0
21	L:L:C22	L:L:L19	6.35	No	No	0	0	0
22	L:L:C22	L:L:C49	7.28	No	No	0	0	0
23	L:L:C23	L:L:M27	3.24	No	Yes	2	0	0
24	L:L:C23	L:L:C56	7.28	No	Yes	2	0	0
25	L:L:D25	L:L:G26	6.71	Yes	No	7	0	0
26	L:L:D25	L:L:R39	3.57	Yes	Yes	7	0	0
27	L:L:D25	L:L:F53	8.36	Yes	Yes	7	0	0
28	L:L:F53	L:L:G26	4.52	Yes	No	7	0	0
29	L:L:C56	L:L:M27	4.86	Yes	Yes	2	0	0
30	L:L:I60	L:L:M27	10.2	No	Yes	2	0	0
31	L:L:N30	L:L:R33	13.26	No	No	0	0	0
32	L:L:N30	L:L:R39	7.23	No	Yes	0	0	0
33	L:L:F34	L:L:M32	7.46	No	No	0	0	0
34	L:L:M32	L:L:R39	3.72	No	Yes	0	0	0
35	L:L:F42	L:L:M32	3.73	No	No	0	0	0
36	L:L:R33	R:R:E406	9.3	No	No	0	0	1
37	L:L:F34	L:L:R38	17.1	No	Yes	0	0	0
38	L:L:C36	L:L:L54	4.76	No	No	0	0	0
39	L:L:C36	L:L:C57	7.28	No	No	0	0	0
40	L:L:L54	L:L:Q37	10.65	No	No	0	0	0
41	L:L:R38	L:L:R41	10.66	Yes	No	0	0	0
42	L:L:F42	L:L:R38	5.34	No	Yes	0	0	0
43	L:L:F53	L:L:R39	11.76	Yes	Yes	7	0	0
44	L:L:F53	L:L:T40	6.49	Yes	No	0	0	0
45	L:L:F53	L:L:I43	7.54	Yes	No	0	0	0
46	L:L:C56	L:L:D55	4.67	Yes	No	0	0	0
47	L:L:E62	L:L:N58	5.26	No	No	0	0	0
48	L:L:L63	L:L:Y59	4.69	Yes	No	0	0	0
49	L:L:R65	L:L:T61	6.47	No	No	0	0	0
50	L:L:E62	L:L:R65	4.65	No	No	0	0	0
51	L:L:L63	L:L:Q66	2.66	Yes	Yes	0	0	0
52	L:L:H67	L:L:R64	3.39	Yes	No	0	0	0
53	L:L:A68	L:L:R64	4.15	No	No	0	0	0
54	L:L:R65	R:R:D404	16.68	No	No	0	0	4
55	L:L:Q66	L:L:R69	3.5	Yes	No	0	0	0
56	L:L:Q66	R:R:F164	4.68	Yes	Yes	8	0	3
57	L:L:Q66	R:R:K175	5.42	Yes	No	8	0	5
58	L:L:H67	R:R:F164	9.05	Yes	Yes	0	0	3
59	L:L:H67	R:R:T166	5.48	Yes	No	0	0	1
60	L:L:R69	R:R:P405	4.32	No	No	0	0	4
61	L:L:A70	R:R:F164	4.16	No	Yes	0	0	3
62	L:L:H72	L:L:S71	8.37	No	No	0	0	0
63	L:L:H72	R:R:M414	5.25	No	No	0	0	2
64	L:L:L73	L:L:R77	3.64	No	Yes	0	0	0
65	L:L:G74	R:R:H418	3.18	No	No	0	0	4
66	L:L:L75	R:R:H81	12.86	No	No	5	0	7
67	L:L:L75	R:R:W88	3.42	No	Yes	5	0	9
68	L:L:A76	R:R:I421	4.87	No	No	0	0	4
69	L:L:R77	R:R:R161	3.2	Yes	Yes	1	0	8
70	L:L:R77	R:R:Y174	3.09	Yes	Yes	1	0	7
71	L:L:R77	R:R:Y393	22.64	Yes	Yes	1	0	9
72	L:L:R77	R:R:G397	6	Yes	No	0	0	8
73	L:L:R77	R:R:D417	19.06	Yes	No	1	0	8
74	L:L:R77	R:R:I421	3.76	Yes	No	1	0	4
75	R:R:I24	R:R:W18	7.05	No	No	0	7	1
76	R:R:N19	R:R:Q85	3.96	No	No	0	1	5
77	R:R:E20	R:R:P22	3.14	No	Yes	9	4	4
78	R:R:E20	R:R:V23	4.28	No	No	0	4	4
79	R:R:E20	R:R:S415	5.75	No	No	9	4	5
80	R:R:P21	R:R:P22	5.84	No	Yes	0	6	4
81	R:R:P22	R:R:S415	8.91	Yes	No	9	4	5
82	R:R:P22	R:R:W416	9.46	Yes	No	0	4	7
83	R:R:L82	R:R:V23	2.98	No	No	0	7	4
84	R:R:I24	R:R:M27	2.92	No	No	0	7	6
85	R:R:I29	R:R:L25	4.28	No	No	0	7	5
86	R:R:L25	R:R:V419	7.45	No	No	0	5	5
87	R:R:L30	R:R:S26	3	Yes	Yes	4	6	8
88	R:R:L82	R:R:S26	7.51	No	Yes	4	7	8
89	R:R:H418	R:R:S26	2.79	No	Yes	4	4	8
90	R:R:A422	R:R:S26	3.42	No	Yes	4	8	8
91	R:R:L79	R:R:M27	2.83	No	No	0	6	6
92	R:R:A422	R:R:I29	3.25	No	No	0	8	7
93	R:R:L30	R:R:L79	2.77	Yes	No	0	6	6
94	R:R:A422	R:R:L30	3.15	No	Yes	4	8	6
95	R:R:L30	R:R:S425	3	Yes	No	0	6	8
96	R:R:L75	R:R:T33	2.95	Yes	No	0	9	8
97	R:R:C429	R:R:T33	5.07	No	No	0	9	8
98	R:R:F34	R:R:L38	8.53	No	Yes	0	7	7
99	R:R:F34	R:R:L75	3.65	No	Yes	0	7	9
100	R:R:F34	R:R:P76	5.78	No	No	0	7	9
101	R:R:C429	R:R:G37	3.92	No	No	0	9	9
102	R:R:C72	R:R:L38	3.17	No	Yes	0	8	7
103	R:R:L38	R:R:L73	2.77	Yes	No	0	7	8
104	R:R:D68	R:R:N41	6.73	Yes	No	0	9	9
105	R:R:L69	R:R:N41	2.75	No	No	0	7	9
106	R:R:N41	R:R:P432	8.15	No	No	0	9	9
107	R:R:G42	R:R:L69	3.42	No	No	0	6	7
108	R:R:L43	R:R:V47	2.98	No	Yes	0	8	8
109	R:R:I450	R:R:L43	7.14	No	No	0	4	8
110	R:R:T65	R:R:V44	3.17	No	Yes	0	9	9
111	R:R:P432	R:R:V44	3.53	No	Yes	0	9	9
112	R:R:A436	R:R:V44	3.39	No	Yes	3	8	9
113	R:R:F442	R:R:V44	9.18	Yes	Yes	3	9	9
114	R:R:L45	R:R:L62	2.77	No	Yes	0	8	8
115	R:R:L45	R:R:T65	7.37	No	No	0	8	9
116	R:R:L45	R:R:L69	4.15	No	No	0	8	7
117	R:R:K51	R:R:W46	3.48	No	Yes	3	9	6
118	R:R:S449	R:R:W46	6.18	No	Yes	3	9	6
119	R:R:I453	R:R:W46	3.52	No	Yes	0	7	6
120	R:R:K51	R:R:V47	3.04	No	Yes	3	9	8
121	R:R:M52	R:R:V47	3.04	No	Yes	3	9	8
122	R:R:F442	R:R:V47	6.55	Yes	Yes	3	9	8
123	R:R:S449	R:R:V47	3.23	No	Yes	3	9	8
124	R:R:A48	R:R:L62	3.15	No	Yes	0	7	8
125	R:R:G49	R:R:L62	3.42	No	Yes	0	7	8
126	R:R:K51	R:R:S449	6.12	No	No	3	9	9
127	R:R:F442	R:R:M52	2.49	Yes	No	3	9	9
128	R:R:K445	R:R:M52	7.2	No	No	0	7	9
129	R:R:I59	R:R:R54	2.51	Yes	No	0	6	7
130	R:R:L62	R:R:R54	3.64	Yes	No	0	8	7
131	R:R:T55	R:R:T58	6.28	No	No	0	9	8
132	R:R:R134	R:R:V56	14.38	Yes	No	0	9	8
133	R:R:N57	R:R:R134	3.62	No	Yes	0	8	9
134	R:R:L62	R:R:T58	2.95	Yes	No	0	8	8
135	R:R:H63	R:R:I59	2.65	Yes	Yes	0	8	6
136	R:R:I59	R:R:V136	3.07	Yes	No	0	6	7
137	R:R:A139	R:R:I59	3.25	No	Yes	0	7	6
138	R:R:C140	R:R:I59	4.91	No	Yes	0	4	6
139	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
140	R:R:I116	R:R:W60	5.87	No	Yes	0	9	8
141	R:R:D119	R:R:W60	10.05	No	Yes	0	9	8
142	R:R:A139	R:R:W60	3.89	No	Yes	0	7	8
143	R:R:I142	R:R:W60	3.52	No	Yes	0	5	8
144	R:R:C143	R:R:W60	5.22	No	Yes	0	8	8
145	R:R:A436	R:R:F61	4.16	No	No	0	8	8
146	R:R:H63	R:R:L112	2.57	Yes	No	0	8	9
147	R:R:C143	R:R:H63	13.27	No	Yes	0	8	8
148	R:R:H63	R:R:W147	7.41	Yes	No	0	8	9
149	R:R:D68	R:R:L64	6.79	Yes	Yes	1	9	9
150	R:R:L64	R:R:S109	3	Yes	No	1	9	9
151	R:R:L112	R:R:L64	2.77	No	Yes	0	9	9
152	R:R:L113	R:R:L64	5.54	No	Yes	1	8	9
153	R:R:L64	R:R:N431	6.87	Yes	Yes	1	9	9
154	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
155	R:R:A67	R:R:W147	2.59	No	No	0	9	9
156	R:R:D68	R:R:S109	4.42	Yes	No	1	9	9
157	R:R:D68	R:R:S428	7.36	Yes	No	0	9	9
158	R:R:D68	R:R:N431	10.77	Yes	Yes	1	9	9
159	R:R:L70	R:R:N105	13.73	No	No	0	6	9
160	R:R:C71	R:R:S428	5.16	No	No	0	8	9
161	R:R:C72	R:R:L75	3.17	No	Yes	0	8	9
162	R:R:I102	R:R:S74	3.1	No	No	0	8	9
163	R:R:L75	R:R:S425	3	Yes	No	0	9	8
164	R:R:G86	R:R:H81	4.77	No	No	0	7	7
165	R:R:H81	R:R:W88	5.29	No	Yes	5	7	9
166	R:R:H418	R:R:L82	5.14	No	No	4	4	7
167	R:R:L84	R:R:Q87	3.99	No	No	0	8	6
168	R:R:G86	R:R:R171	4.5	No	No	0	7	1
169	R:R:H169	R:R:Q87	19.78	No	No	0	3	6
170	R:R:Q87	R:R:R171	5.84	No	No	0	6	1
171	R:R:P89	R:R:W88	2.7	No	Yes	5	8	9
172	R:R:W88	R:R:Y90	9.65	Yes	Yes	5	9	7
173	R:R:C95	R:R:W88	9.14	No	Yes	0	9	9
174	R:R:P89	R:R:Y90	5.56	No	Yes	5	8	7
175	R:R:L94	R:R:Y90	5.86	No	Yes	0	8	7
176	R:R:K96	R:R:R92	8.66	No	No	0	8	1
177	R:R:E162	R:R:R92	8.14	No	No	0	5	1
178	R:R:I163	R:R:R92	3.76	No	No	0	6	1
179	R:R:F93	R:R:L97	3.65	No	No	0	4	6
180	R:R:C172	R:R:C95	7.28	No	No	0	8	9
181	R:R:F158	R:R:K96	2.48	No	No	0	8	8
182	R:R:K96	R:R:R161	2.48	No	Yes	0	8	8
183	R:R:L97	R:R:S100	4.5	No	No	0	6	8
184	R:R:I101	R:R:L97	2.85	No	No	0	5	6
185	R:R:I98	R:R:P99	3.39	No	No	0	8	8
186	R:R:P99	R:R:R161	8.65	No	Yes	0	8	8
187	R:R:I101	R:R:N105	4.25	No	No	0	5	9
188	R:R:I102	R:R:M106	2.92	No	No	0	8	9
189	R:R:F107	R:R:V103	2.62	No	Yes	1	8	5
190	R:R:C154	R:R:V103	3.42	No	Yes	0	8	5
191	R:R:V103	R:R:V157	6.41	Yes	No	0	5	9
192	R:R:R340	R:R:V103	2.62	Yes	Yes	1	9	5
193	R:R:L104	R:R:N105	2.75	No	No	0	8	9
194	R:R:F151	R:R:L104	3.65	No	No	0	5	8
195	R:R:C154	R:R:L104	4.76	No	No	0	8	8
196	R:R:M106	R:R:W390	4.65	No	Yes	0	9	9
197	R:R:F107	R:R:M153	11.2	No	Yes	1	8	8
198	R:R:F107	R:R:R340	6.41	No	Yes	1	8	9
199	R:R:A108	R:R:W147	5.19	No	No	0	9	9
200	R:R:P348	R:R:V110	3.53	Yes	No	1	9	9
201	R:R:F386	R:R:V110	3.93	Yes	No	1	9	9
202	R:R:V110	R:R:W390	7.36	No	Yes	1	9	9
203	R:R:F111	R:R:V149	3.93	No	No	0	8	4
204	R:R:F111	R:R:M153	2.49	No	Yes	1	8	8
205	R:R:F111	R:R:V343	2.62	No	No	1	8	4
206	R:R:I146	R:R:L112	5.71	No	No	0	8	9
207	R:R:L113	R:R:N431	8.24	No	Yes	1	8	9
208	R:R:L113	R:R:Y435	12.89	No	Yes	1	8	9
209	R:R:P348	R:R:T114	5.25	Yes	No	0	9	8
210	R:R:I351	R:R:T114	4.56	No	No	0	6	8
211	R:R:I116	R:R:R120	5.01	No	No	0	9	9
212	R:R:I116	R:R:Y435	3.63	No	Yes	0	9	9
213	R:R:M352	R:R:S117	4.6	No	No	0	8	9
214	R:R:C355	R:R:S117	5.16	No	No	0	9	9
215	R:R:S117	R:R:Y356	7.63	No	Yes	0	9	9
216	R:R:I351	R:R:L118	4.28	No	No	0	6	8
217	R:R:D119	R:R:R134	11.91	No	Yes	0	9	9
218	R:R:R120	R:R:Y356	8.23	No	Yes	0	9	9
219	R:R:C121	R:R:C355	7.28	No	No	0	9	9
220	R:R:C121	R:R:F358	4.19	No	No	0	9	6
221	R:R:L122	R:R:W129	6.83	No	No	6	7	6
222	R:R:C130	R:R:L122	4.76	Yes	No	6	7	7
223	R:R:C130	R:R:V123	5.12	Yes	No	6	7	5
224	R:R:R134	R:R:V123	6.54	Yes	No	6	9	5
225	R:R:I359	R:R:V124	4.61	No	No	0	9	9
226	R:R:R362	R:R:V124	2.62	No	No	0	7	9
227	R:R:F125	R:R:K126	9.93	No	No	0	6	6
228	R:R:F125	R:R:F358	8.57	No	No	0	6	6
229	R:R:C130	R:R:W129	2.61	Yes	No	6	7	6
230	R:R:H133	R:R:W129	15.87	No	No	0	8	6
231	R:R:C130	R:R:R134	4.18	Yes	Yes	6	7	9
232	R:R:H133	R:R:N132	2.55	No	No	0	8	8
233	R:R:M138	R:R:R134	2.48	No	Yes	0	6	9
234	R:R:I142	R:R:M138	4.37	No	No	0	5	6
235	R:R:I142	R:R:I146	2.94	No	No	0	5	8
236	R:R:F151	R:R:I155	3.77	No	No	0	5	5
237	R:R:M153	R:R:R340	2.48	Yes	Yes	1	8	9
238	R:R:M153	R:R:V343	6.09	Yes	No	1	8	4
239	R:R:I155	R:R:P156	3.39	No	No	0	5	9
240	R:R:P156	R:R:Y160	2.78	No	Yes	0	9	8
241	R:R:I336	R:R:P156	10.16	No	No	0	7	9
242	R:R:V157	R:R:Y174	3.79	No	Yes	0	9	7
243	R:R:V159	R:R:Y160	7.57	No	Yes	0	4	8
244	R:R:T331	R:R:Y160	6.24	No	Yes	10	4	8
245	R:R:P332	R:R:Y160	2.78	No	Yes	10	4	8
246	R:R:C172	R:R:R161	2.79	No	Yes	0	8	8
247	R:R:R161	R:R:Y174	19.55	Yes	Yes	1	8	7
248	R:R:E162	R:R:F164	3.5	No	Yes	8	5	3
249	R:R:E162	R:R:K175	5.4	No	No	8	5	5
250	R:R:I163	R:R:N170	2.83	No	No	0	6	4
251	R:R:F164	R:R:K175	3.72	Yes	No	8	3	5
252	R:R:N170	R:R:T165	4.39	No	No	0	4	4
253	R:R:H169	R:R:N168	19.13	No	No	0	3	5
254	R:R:L333	R:R:Y174	10.55	No	Yes	0	3	7
255	R:R:P332	R:R:T331	3.5	No	No	10	4	4
256	R:R:L333	R:R:L401	4.15	No	No	0	3	7
257	R:R:I336	R:R:R340	2.51	No	Yes	0	7	9
258	R:R:L401	R:R:T337	5.9	No	No	0	7	7
259	R:R:R340	R:R:Y393	3.09	Yes	Yes	1	9	9
260	R:R:F345	R:R:L341	3.65	Yes	No	1	9	6
261	R:R:L341	R:R:L346	2.77	No	No	1	6	8
262	R:R:H394	R:R:L341	5.14	Yes	No	1	9	6
263	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
264	R:R:F345	R:R:L346	3.65	Yes	No	1	9	8
265	R:R:F345	R:R:T391	7.78	Yes	Yes	0	9	6
266	R:R:F345	R:R:H394	13.58	Yes	Yes	1	9	9
267	R:R:F386	R:R:P348	2.89	Yes	Yes	1	9	9
268	R:R:I353	R:R:S349	3.1	No	No	0	5	4
269	R:R:L387	R:R:S349	6.01	No	No	0	6	4
270	R:R:F386	R:R:M352	8.71	Yes	No	0	9	8
271	R:R:I353	R:R:V383	3.07	No	No	0	5	8
272	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
273	R:R:V382	R:R:Y356	3.79	No	Yes	0	8	9
274	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
275	R:R:F358	R:R:R362	7.48	No	No	0	6	7
276	R:R:Q364	R:R:V360	4.3	No	Yes	0	5	6
277	R:R:F376	R:R:V360	6.55	No	Yes	0	4	6
278	R:R:F361	R:R:R365	9.62	No	No	0	4	4
279	R:R:F368	R:R:R367	8.55	No	No	0	5	6
280	R:R:K370	R:R:Q372	4.07	No	No	0	7	5
281	R:R:Q372	R:R:T375	5.67	No	No	0	5	7
282	R:R:R377	R:R:S373	3.95	No	No	0	5	4
283	R:R:K374	R:R:V378	3.04	No	No	0	9	8
284	R:R:F376	R:R:V380	7.87	No	No	0	4	3
285	R:R:L438	R:R:V378	2.98	No	No	0	7	8
286	R:R:V382	R:R:Y435	3.79	No	Yes	0	8	9
287	R:R:L387	R:R:V383	2.98	No	No	0	6	8
288	R:R:L434	R:R:V385	4.47	No	No	0	9	7
289	R:R:F386	R:R:W390	7.02	Yes	Yes	1	9	9
290	R:R:F386	R:R:N427	4.83	Yes	Yes	1	9	9
291	R:R:L387	R:R:T391	2.95	No	Yes	0	6	6
292	R:R:C389	R:R:N427	7.87	No	Yes	0	9	9
293	R:R:W390	R:R:Y393	3.86	Yes	Yes	1	9	9
294	R:R:H394	R:R:W390	3.17	Yes	Yes	1	9	9
295	R:R:A424	R:R:W390	3.89	No	Yes	0	9	9
296	R:R:N427	R:R:W390	9.04	Yes	Yes	1	9	9
297	R:R:P392	R:R:T391	3.5	No	Yes	0	9	6
298	R:R:I395	R:R:T391	3.04	No	Yes	0	5	6
299	R:R:L423	R:R:P392	4.93	No	No	0	8	9
300	R:R:H394	R:R:Y393	8.71	Yes	Yes	1	9	9
301	R:R:I395	R:R:L399	2.85	No	No	0	5	9
302	R:R:F396	R:R:L413	4.87	Yes	Yes	0	4	7
303	R:R:C420	R:R:F396	5.59	No	Yes	0	6	4
304	R:R:L413	R:R:S400	4.5	Yes	No	0	7	2
305	R:R:L409	R:R:T403	2.95	No	No	11	3	2
306	R:R:L413	R:R:T403	4.42	Yes	No	11	7	2
307	R:R:D404	R:R:P405	4.83	No	No	0	4	4
308	R:R:D404	R:R:E406	2.6	No	No	0	4	1
309	R:R:L409	R:R:L413	2.77	No	Yes	11	3	7
310	R:R:V419	R:R:W416	7.36	No	No	0	5	7
311	R:R:D417	R:R:I421	2.8	No	No	1	8	4
312	R:R:N427	R:R:N431	6.81	Yes	Yes	1	9	9
313	R:R:N431	R:R:Y435	5.81	Yes	Yes	1	9	9
314	R:R:F433	R:R:L437	3.65	No	No	0	6	7
315	R:R:L434	R:R:Y435	4.69	No	Yes	0	9	9
316	R:R:A436	R:R:F442	5.55	No	Yes	3	8	9
317	R:R:F442	R:R:L437	4.87	Yes	No	0	9	7
318	R:R:F396	R:R:L399	2.44	Yes	No	0	4	9
319	R:R:F430	R:R:L434	2.44	No	No	0	7	9
320	L:L:D25	L:L:R28	2.38	Yes	No	0	0	0
321	R:R:L50	R:R:W46	2.28	No	Yes	0	4	6
322	R:R:G40	R:R:P39	2.03	No	No	0	9	7
323	R:R:F396	R:R:W416	2	Yes	No	0	4	7
324	R:R:C143	R:R:G144	1.96	No	No	0	8	5
325	R:R:A369	R:R:G366	1.95	No	No	0	5	2
326	R:R:A335	R:R:P332	1.87	No	No	0	5	4
327	L:L:G13	L:L:V12	1.84	No	No	0	0	0
328	R:R:G410	R:R:T403	1.82	No	No	0	3	2
329	R:R:G410	R:R:T407	1.82	No	No	0	3	7
330	R:R:A108	R:R:A150	1.79	No	No	0	9	9
331	R:R:P330	R:R:V329	1.77	No	No	0	2	3
332	R:R:P408	R:R:T407	1.75	No	No	0	4	7
333	L:L:C23	L:L:V52	1.71	No	No	2	0	0
334	L:L:C56	L:L:V52	1.71	Yes	No	2	0	0
335	L:L:L73	R:R:G173	1.71	No	No	0	0	1
336	R:R:G37	R:R:L36	1.71	No	No	0	9	8
337	R:R:C145	R:R:V149	1.71	No	No	0	6	4
338	R:R:A446	R:R:V47	1.7	No	Yes	0	8	8
339	R:R:G137	R:R:N135	1.7	No	No	0	5	5
340	R:R:A379	R:R:V360	1.7	No	Yes	0	7	6
341	L:L:C57	L:L:T61	1.69	No	No	0	0	0
342	R:R:I128	R:R:P127	1.69	No	No	0	7	9
343	R:R:A426	R:R:T33	1.68	No	No	0	8	8
344	R:R:M414	R:R:P405	1.68	No	No	0	2	4
345	R:R:K126	R:R:P127	1.67	No	No	0	6	9
346	L:L:C49	L:L:I43	1.64	No	No	0	0	0
347	R:R:L38	R:R:P39	1.64	Yes	No	0	7	7
348	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
349	R:R:G452	R:R:Q451	1.64	No	No	0	6	6
350	L:L:N30	L:L:P31	1.63	No	No	0	0	0
351	R:R:V148	R:R:V152	1.6	No	No	0	5	5
352	R:R:V378	R:R:V382	1.6	No	No	0	8	8
353	R:R:V381	R:R:V385	1.6	No	No	0	7	7
354	R:R:T337	R:R:V398	1.59	No	No	0	7	7
355	R:R:T339	R:R:V343	1.59	No	No	0	8	4
356	R:R:T375	R:R:V360	1.59	No	Yes	0	7	6
357	R:R:I353	R:R:S357	1.55	No	No	0	5	6
358	R:R:I338	R:R:V334	1.54	No	No	0	6	4
359	R:R:I338	R:R:V342	1.54	No	No	0	6	6
360	R:R:M363	R:R:V124	1.52	No	No	0	7	9
361	L:L:L75	R:R:S78	1.5	No	No	0	0	8
362	R:R:L32	R:R:S31	1.5	No	No	0	6	7
363	R:R:L32	R:R:V28	1.49	No	No	0	6	6
364	R:R:L401	R:R:V334	1.49	No	No	0	7	4
365	R:R:L346	R:R:V342	1.49	No	No	0	8	6
366	R:R:L402	R:R:V398	1.49	No	No	0	5	7
367	R:R:L409	R:R:T412	1.47	No	No	0	3	6
368	R:R:G91	R:R:Y90	1.45	No	Yes	0	9	7
369	L:L:K11	L:L:K14	1.44	Yes	No	0	0	0
370	R:R:I450	R:R:L454	1.43	No	No	0	4	8
371	R:R:M138	R:R:N135	1.4	No	No	0	6	5
372	R:R:L66	R:R:L70	1.38	No	No	0	4	6
373	R:R:K444	R:R:Q448	1.36	No	No	0	5	7
374	L:L:E18	L:L:L19	1.33	No	No	0	0	0
375	L:L:R38	L:L:S35	1.32	Yes	No	0	0	0
376	R:R:F77	R:R:I98	1.26	No	No	0	8	8
377	R:R:L438	R:R:R443	1.21	No	No	0	7	9
378	L:L:K51	L:L:Y15	1.19	No	No	0	0	0
379	L:L:E24	L:L:R20	1.16	No	No	0	0	0
380	L:L:E24	L:L:R28	1.16	No	No	0	0	0
381	L:L:E18	L:L:Y15	1.12	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:S1	3.9975	4	2	0
2	L:L:Q3	5.27	4	0	0
3	L:L:L4	4.5425	4	2	0
4	L:L:R8	4.135	4	2	0
5	L:L:K11	6.015	4	0	0
6	L:L:D25	5.255	4	7	0
7	L:L:M27	5.764	5	2	0
8	L:L:R38	8.605	4	0	0
9	L:L:R39	6.57	4	7	0
10	L:L:F53	7.734	5	7	0
11	L:L:C56	4.63	4	2	0
12	L:L:L63	3.235	4	0	0
13	L:L:Q66	4.065	4	8	0
14	L:L:H67	6.0875	4	0	0
15	L:L:R77	8.77	7	1	0
16	R:R:P22	6.8375	4	9	4
17	R:R:S26	4.18	4	4	8
18	R:R:L30	2.98	4	4	6
19	R:R:L38	4.0275	4	0	7
20	R:R:V44	4.8175	4	3	9
21	R:R:W46	3.865	4	3	6
22	R:R:V47	3.42333	6	3	8
23	R:R:I59	3.278	5	0	6
24	R:R:W60	5.40667	6	0	8
25	R:R:L62	3.186	5	0	8
26	R:R:H63	6.475	4	0	8
27	R:R:L64	4.74833	6	1	9
28	R:R:D68	7.214	5	1	9
29	R:R:L75	3.1925	4	0	9
30	R:R:W88	6.04	5	5	9
31	R:R:Y90	5.63	4	5	7
32	R:R:V103	3.7675	4	1	5
33	R:R:C130	4.1675	4	6	7
34	R:R:R134	7.185	6	6	9
35	R:R:M153	5.565	4	1	8
36	R:R:Y160	4.8425	4	10	8
37	R:R:R161	7.334	5	1	8
38	R:R:F164	5.022	5	8	3
39	R:R:Y174	9.245	4	1	7
40	R:R:R340	3.422	5	1	9
41	R:R:F345	7.165	4	1	9
42	R:R:P348	3.474	5	1	9
43	R:R:Y356	5.488	5	0	9
44	R:R:V360	3.535	4	0	6
45	R:R:F386	5.476	5	1	9
46	R:R:W390	5.57	7	1	9
47	R:R:T391	4.3175	4	0	6
48	R:R:Y393	9.575	4	1	9
49	R:R:H394	7.65	4	1	9
50	R:R:F396	3.725	4	0	4
51	R:R:L413	4.14	4	11	7
52	R:R:N427	7.1375	4	1	9
53	R:R:N431	7.7	5	1	9
54	R:R:Y435	5.72167	6	1	9
55	R:R:F442	5.728	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L63	L:L:Y59	17.0165	4.69	Yes	No	0	0	0
2	L:L:C49	L:L:I43	11.0403	1.64	No	No	0	0	0
3	L:L:F53	L:L:I43	12.5973	7.54	Yes	No	0	0	0
4	L:L:F53	L:L:R39	17.1244	11.76	Yes	Yes	7	0	0
5	L:L:N30	L:L:R39	39.8063	7.23	No	Yes	0	0	0
6	L:L:N30	L:L:R33	42.7276	13.26	No	No	0	0	0
7	L:L:R33	R:R:E406	44.1304	9.3	No	No	0	0	1
8	R:R:D404	R:R:E406	45.5795	2.6	No	No	0	4	1
9	R:R:D404	R:R:P405	58.3156	4.83	No	No	0	4	4
10	L:L:R69	R:R:P405	63.8653	4.32	No	No	0	0	4
11	L:L:Q66	L:L:R69	65.2398	3.5	Yes	No	0	0	0
12	L:L:L63	L:L:Q66	21.1531	2.66	Yes	Yes	0	0	0
13	L:L:M32	L:L:R39	14.1723	3.72	No	Yes	0	0	0
14	L:L:R65	R:R:D404	12.5562	16.68	No	No	0	0	4
15	L:L:H67	R:R:F164	11.6955	9.05	Yes	Yes	0	0	3
16	L:L:Q66	R:R:K175	40.6233	5.42	Yes	No	8	0	5
17	L:L:R77	R:R:R161	95.3778	3.2	Yes	Yes	1	0	8
18	R:R:K96	R:R:R161	99.6223	2.48	No	Yes	0	8	8
19	R:R:K96	R:R:R92	98.9954	8.66	No	No	0	8	1
20	R:R:E162	R:R:R92	94.4631	8.14	No	No	0	5	1
21	R:R:E162	R:R:F164	52.9714	3.5	No	Yes	8	5	3
22	R:R:F396	R:R:W416	37.7817	2	Yes	No	0	4	7
23	R:R:F396	R:R:L399	46.4916	2.44	Yes	No	0	4	9
24	R:R:I395	R:R:L399	47.3343	2.85	No	No	0	5	9
25	R:R:I395	R:R:T391	48.1719	3.04	No	Yes	0	5	6
26	R:R:F345	R:R:T391	43.9249	7.78	Yes	Yes	0	9	6
27	R:R:F345	R:R:H394	44.7727	13.58	Yes	Yes	1	9	9
28	R:R:H394	R:R:Y393	35.5309	8.71	Yes	Yes	1	9	9
29	L:L:R77	R:R:Y393	100	22.64	Yes	Yes	1	0	9
30	R:R:C95	R:R:W88	14.3136	9.14	No	Yes	0	9	9
31	R:R:C172	R:R:C95	15.2977	7.28	No	No	0	8	9
32	R:R:C172	R:R:R161	16.2766	2.79	No	Yes	0	8	8
33	R:R:V419	R:R:W416	27.9541	7.36	No	No	0	5	7
34	R:R:L25	R:R:V419	27.0188	7.45	No	No	0	5	5
35	R:R:I29	R:R:L25	26.0836	4.28	No	No	0	7	5
36	R:R:A422	R:R:I29	25.1484	3.25	No	No	0	8	7
37	R:R:A422	R:R:L30	23.1623	3.15	No	Yes	4	8	6
38	R:R:L30	R:R:S425	18.7739	3	Yes	No	0	6	8
39	R:R:L75	R:R:S425	17.7745	3	Yes	No	0	9	8
40	R:R:W390	R:R:Y393	71.9021	3.86	Yes	Yes	1	9	9
41	R:R:N427	R:R:W390	59.8083	9.04	Yes	Yes	1	9	9
42	R:R:N427	R:R:N431	61.815	6.81	Yes	Yes	1	9	9
43	R:R:D68	R:R:N431	32.918	10.77	Yes	Yes	1	9	9
44	R:R:D68	R:R:N41	35.0556	6.73	Yes	No	0	9	9
45	R:R:N41	R:R:P432	25.747	8.15	No	No	0	9	9
46	R:R:P432	R:R:V44	24.6602	3.53	No	Yes	0	9	9
47	R:R:F442	R:R:V44	21.7954	9.18	Yes	Yes	3	9	9
48	R:R:F442	R:R:V47	15.8732	6.55	Yes	Yes	3	9	8
49	R:R:L64	R:R:N431	12.9236	6.87	Yes	Yes	1	9	9
50	R:R:L112	R:R:L64	15.1332	2.77	No	Yes	0	9	9
51	R:R:N431	R:R:Y435	23.0261	5.81	Yes	Yes	1	9	9
52	R:R:I116	R:R:Y435	15.7576	3.63	No	Yes	0	9	9
53	R:R:I116	R:R:W60	21.7286	5.87	No	Yes	0	9	8
54	R:R:D119	R:R:W60	11.2998	10.05	No	Yes	0	9	8
55	R:R:D119	R:R:R134	10.2001	11.91	No	Yes	0	9	9
56	R:R:C154	R:R:V103	10.4648	3.42	No	Yes	0	8	5
57	R:R:R340	R:R:Y393	22.6484	3.09	Yes	Yes	1	9	9
58	R:R:F386	R:R:W390	18.3757	7.02	Yes	Yes	1	9	9
59	R:R:F386	R:R:M352	15.2565	8.71	Yes	No	0	9	8
60	R:R:M352	R:R:S117	14.6605	4.6	No	No	0	8	9
61	R:R:S117	R:R:Y356	12.2556	7.63	No	Yes	0	9	9
62	R:R:C355	R:R:S117	13.0829	5.16	No	No	0	9	9
63	R:R:C121	R:R:C355	11.919	7.28	No	No	0	9	9
64	R:R:C121	R:R:F358	10.75	4.19	No	No	0	9	6
65	R:R:L387	R:R:T391	16.4179	2.95	No	Yes	0	6	6
66	R:R:L387	R:R:V383	14.2802	2.98	No	No	0	6	8
67	R:R:V382	R:R:Y435	11.9987	3.79	No	Yes	0	8	9
68	L:L:K11	L:L:Y59	15.5263	15.53	Yes	No	0	0	0
69	L:L:Q66	R:R:F164	41.2245	4.68	Yes	Yes	8	0	3
70	R:R:E162	R:R:K175	41.1449	5.4	No	No	8	5	5
71	R:R:H394	R:R:W390	13.0624	3.17	Yes	Yes	1	9	9
72	R:R:V383	R:R:Y356	13.7432	3.79	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q3	R:R:T165	2.83	0	Yes	No	0	4	0	1
L:L:Q3	R:R:D167	6.53	0	Yes	No	0	3	0	1
L:L:R33	R:R:E406	9.3	0	No	No	0	1	0	1
L:L:R65	R:R:D404	16.68	0	No	No	0	4	0	1
L:L:Q66	R:R:F164	4.68	8	Yes	Yes	0	3	0	1
L:L:Q66	R:R:K175	5.42	8	Yes	No	0	5	0	1
L:L:H67	R:R:F164	9.05	0	Yes	Yes	0	3	0	1
L:L:H67	R:R:T166	5.48	0	Yes	No	0	1	0	1
L:L:R69	R:R:P405	4.32	0	No	No	0	4	0	1
L:L:A70	R:R:F164	4.16	0	No	Yes	0	3	0	1
L:L:H72	R:R:M414	5.25	0	No	No	0	2	0	1
L:L:G74	R:R:H418	3.18	0	No	No	0	4	0	1
L:L:L75	R:R:H81	12.86	5	No	No	0	7	0	1
L:L:L75	R:R:W88	3.42	5	No	Yes	0	9	0	1
L:L:A76	R:R:I421	4.87	0	No	No	0	4	0	1
L:L:R77	R:R:R161	3.2	1	Yes	Yes	0	8	0	1
L:L:R77	R:R:Y174	3.09	1	Yes	Yes	0	7	0	1
L:L:R77	R:R:Y393	22.64	1	Yes	Yes	0	9	0	1
L:L:R77	R:R:G397	6	1	Yes	No	0	8	0	1
L:L:R77	R:R:D417	19.06	1	Yes	No	0	8	0	1
L:L:R77	R:R:I421	3.76	1	Yes	No	0	4	0	1
R:R:L82	R:R:S26	7.51	4	No	Yes	7	8	2	2
R:R:H418	R:R:S26	2.79	4	No	Yes	4	8	1	2
R:R:G86	R:R:H81	4.77	0	No	No	7	7	2	1
R:R:H81	R:R:W88	5.29	5	No	Yes	7	9	1	1
R:R:H418	R:R:L82	5.14	4	No	No	4	7	1	2
R:R:P89	R:R:W88	2.7	5	No	Yes	8	9	2	1
R:R:W88	R:R:Y90	9.65	5	Yes	Yes	9	7	1	2
R:R:C95	R:R:W88	9.14	0	No	Yes	9	9	2	1
R:R:P89	R:R:Y90	5.56	5	No	Yes	8	7	2	2
R:R:C172	R:R:C95	7.28	0	No	No	8	9	2	2
R:R:K96	R:R:R161	2.48	0	No	Yes	8	8	2	1
R:R:P99	R:R:R161	8.65	0	No	Yes	8	8	2	1
R:R:V157	R:R:Y174	3.79	0	No	Yes	9	7	2	1
R:R:C172	R:R:R161	2.79	0	No	Yes	8	8	2	1
R:R:R161	R:R:Y174	19.55	1	Yes	Yes	8	7	1	1
R:R:E162	R:R:F164	3.5	8	No	Yes	5	3	2	1
R:R:E162	R:R:K175	5.4	8	No	No	5	5	2	1
R:R:F164	R:R:K175	3.72	8	Yes	No	3	5	1	1
R:R:N170	R:R:T165	4.39	0	No	No	4	4	2	1
R:R:L333	R:R:Y174	10.55	0	No	Yes	3	7	2	1
R:R:R340	R:R:Y393	3.09	1	Yes	Yes	9	9	2	1
R:R:W390	R:R:Y393	3.86	1	Yes	Yes	9	9	2	1
R:R:H394	R:R:W390	3.17	1	Yes	Yes	9	9	2	2
R:R:H394	R:R:Y393	8.71	1	Yes	Yes	9	9	2	1
R:R:D404	R:R:P405	4.83	0	No	No	4	4	1	1
R:R:D404	R:R:E406	2.6	0	No	No	4	1	1	1
R:R:D417	R:R:I421	2.8	1	No	No	8	4	1	1
L:L:L73	R:R:G173	1.71	0	No	No	0	1	0	1
R:R:M414	R:R:P405	1.68	0	No	No	2	4	1	1
L:L:L75	R:R:S78	1.5	5	No	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HK2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.48
Number of Linked Nodes	336
Number of Links	381
Number of Hubs	55
Number of Links mediated by Hubs	208
Number of Communities	11
Number of Nodes involved in Communities	76
Number of Links involved in Communities	102

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	80128
Length Of Smallest Path	3
Average Path Length	16.5453
Length of Longest Path	41
Minimum Path Strength	1.155
Average Path Strength	5.97897
Maximum Path Strength	20.85
Minimum Path Correlation	0.7
Average Path Correlation	0.950849
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	55.9444
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1117
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • response to stimulus • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of biological process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • response to chemical • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • biological regulation • positive regulation of leukocyte migration • regulation of chemotaxis • cellular response to chemical stimulus • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular process • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • system process • circulatory system process • blood circulation • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • specific granule membrane • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • specific granule membrane • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • peptidase activity • peptidase regulator activity • catalytic activity, acting on a protein • enzyme inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • molecular function inhibitor activity • endopeptidase activity • C5L2 anaphylatoxin chemotactic receptor binding • C5a anaphylatoxin chemotactic receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of signaling • neutral lipid metabolic process • neutral lipid biosynthetic process • regulation of triglyceride metabolic process • acylglycerol biosynthetic process • triglyceride metabolic process • triglyceride biosynthetic process • regulation of triglyceride biosynthetic process • glycerolipid biosynthetic process • glycerolipid metabolic process • acylglycerol metabolic process • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • lymphocyte mediated immunity • humoral immune response • complement activation • humoral immune response mediated by circulating immunoglobulin • positive regulation of immune response • leukocyte mediated immunity • regulation of immune system process • positive regulation of immune system process • complement activation, classical pathway • immune response • immunoglobulin mediated immune response • adaptive immune response • immune effector process • B cell mediated immunity • regulation of immune response • activation of immune response • cellular developmental process • cell development • developmental maturation • nervous system development • generation of neurons • neurogenesis • neuron differentiation • neuron remodeling • anatomical structure maturation • cell differentiation • neuron development • neuron maturation • cell maturation • B cell activation • cell activation • lymphocyte activation • leukocyte activation • regulation of humoral immune response • regulation of immune effector process • positive regulation of humoral immune response • positive regulation of complement activation • positive regulation of immune effector process • activation of membrane attack complex • positive regulation of activation of membrane attack complex • regulation of activation of membrane attack complex • regulation of complement activation • pattern specification process • regionalization • central nervous system development • vertebrate eye-specific patterning • import into cell • positive regulation of cellular component organization • transport • vesicle-mediated transport • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of transport • endocytosis • receptor-mediated endocytosis • biological process involved in interspecies interaction between organisms • complement activation, alternative pathway • response to biotic stimulus • innate immune response • response to external biotic stimulus • response to other organism • defense response • defense response to symbiont • response to external stimulus • defense response to other organism • epithelium development • oviduct development • reproductive system development • oviduct epithelium development • tube development • reproductive process • developmental process involved in reproduction • tissue development • reproductive structure development • positive regulation of macromolecule biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • positive regulation of membrane invagination • regulation of phagocytosis, engulfment • membrane invagination • phagocytosis • plasma membrane invagination • membrane organization • regulation of phagocytosis • phagocytosis, engulfment • positive regulation of phagocytosis • positive regulation of phagocytosis, engulfment • regulation of membrane invagination • cellular component disassembly • complement-mediated synapse pruning • cell junction organization • cell junction disassembly • synapse pruning • synapse organization • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • amyloid-beta clearance • lipid storage • lipid localization • positive regulation of lipid localization • regulation of lipid storage • regulation of lipid localization • nutrient storage • positive regulation of lipid storage • fatty acid metabolic process • oxoacid metabolic process • carboxylic acid metabolic process • monocarboxylic acid metabolic process • organic acid metabolic process • positive regulation of acute inflammatory response to antigenic stimulus • regulation of myeloid leukocyte mediated immunity • regulation of acute inflammatory response to antigenic stimulus • positive regulation of leukocyte mediated immunity • regulation of type IIa hypersensitivity • myeloid leukocyte mediated immunity • inflammatory response to antigenic stimulus • positive regulation of hypersensitivity • positive regulation of inflammatory response • positive regulation of adaptive immune response • regulation of type II hypersensitivity • positive regulation of immunoglobulin mediated immune response • hypersensitivity • regulation of adaptive immune response • regulation of inflammatory response • regulation of B cell mediated immunity • regulation of leukocyte mediated immunity • type II hypersensitivity • positive regulation of myeloid leukocyte mediated immunity • type IIa hypersensitivity • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • regulation of defense response • regulation of response to external stimulus • positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of lymphocyte mediated immunity • positive regulation of acute inflammatory response • positive regulation of B cell mediated immunity • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of response to external stimulus • regulation of immunoglobulin mediated immune response • regulation of response to stress • acute inflammatory response • regulation of hypersensitivity • regulation of inflammatory response to antigenic stimulus • acute inflammatory response to antigenic stimulus • positive regulation of inflammatory response to antigenic stimulus • positive regulation of type IIa hypersensitivity • regulation of lymphocyte mediated immunity • positive regulation of type II hypersensitivity • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • response to bacterium • complement-dependent cytotoxicity • cell killing • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • positive regulation of apoptotic cell clearance • apoptotic cell clearance • regulation of apoptotic cell clearance • hexose transmembrane transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • positive regulation of transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • endoplasmic reticulum lumen • endoplasmic reticulum • cell surface • cytoplasmic vesicle lumen • vacuolar lumen • vesicle lumen • secretory granule lumen • azurophil granule lumen • blood microparticle • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8HK2_nogp_Chain_R W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y K V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	10.1016/j.cell.2023.09.020
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	10.1016/j.cell.2023.09.020
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	10.1038/s41589-023-01339-w
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	10.1038/s41589-023-01339-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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