Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:S1 3.9975420
2L:L:Q3 5.27400
3L:L:L4 4.5425420
4L:L:R8 4.135420
5L:L:K11 6.015400
6L:L:D25 5.255470
7L:L:M27 5.764520
8L:L:R38 8.605400
9L:L:R39 6.57470
10L:L:F53 7.734570
11L:L:C56 4.63420
12L:L:L63 3.235400
13L:L:Q66 4.065480
14L:L:H67 6.0875400
15L:L:R77 8.77710
16R:R:P22 6.8375494
17R:R:S26 4.18448
18R:R:L30 2.98446
19R:R:L38 4.0275407
20R:R:V44 4.8175439
21R:R:W46 3.865436
22R:R:V47 3.42333638
23R:R:I59 3.278506
24R:R:W60 5.40667608
25R:R:L62 3.186508
26R:R:H63 6.475408
27R:R:L64 4.74833619
28R:R:D68 7.214519
29R:R:L75 3.1925409
30R:R:W88 6.04559
31R:R:Y90 5.63457
32R:R:V103 3.7675415
33R:R:C130 4.1675467
34R:R:R134 7.185669
35R:R:M153 5.565418
36R:R:Y160 4.84254108
37R:R:R161 7.334518
38R:R:F164 5.022583
39R:R:Y174 9.245417
40R:R:R340 3.422519
41R:R:F345 7.165419
42R:R:P348 3.474519
43R:R:Y356 5.488509
44R:R:V360 3.535406
45R:R:F386 5.476519
46R:R:W390 5.57719
47R:R:T391 4.3175406
48R:R:Y393 9.575419
49R:R:H394 7.65419
50R:R:F396 3.725404
51R:R:L413 4.144117
52R:R:N427 7.1375419
53R:R:N431 7.7519
54R:R:Y435 5.72167619
55R:R:F442 5.728539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:L63 L:L:Y59 17.01654.69YesNo000
2L:L:C49 L:L:I43 11.04031.64NoNo000
3L:L:F53 L:L:I43 12.59737.54YesNo000
4L:L:F53 L:L:R39 17.124411.76YesYes700
5L:L:N30 L:L:R39 39.80637.23NoYes000
6L:L:N30 L:L:R33 42.727613.26NoNo000
7L:L:R33 R:R:E406 44.13049.3NoNo001
8R:R:D404 R:R:E406 45.57952.6NoNo041
9R:R:D404 R:R:P405 58.31814.83NoNo044
10L:L:R69 R:R:P405 63.86784.32NoNo004
11L:L:Q66 L:L:R69 65.24243.5YesNo000
12L:L:L63 L:L:Q66 21.15572.66YesYes000
13L:L:M32 L:L:R39 14.17233.72NoYes000
14L:L:R65 R:R:D404 12.558816.68NoNo004
15L:L:H67 R:R:F164 11.69559.05YesYes003
16L:L:Q66 R:R:K175 40.62335.42YesNo805
17L:L:R77 R:R:R161 95.37783.2YesYes108
18R:R:K96 R:R:R161 99.62232.48NoYes088
19R:R:K96 R:R:R92 98.99548.66NoNo081
20R:R:E162 R:R:R92 94.46318.14NoNo051
21R:R:E162 R:R:F164 52.97143.5NoYes853
22R:R:F396 R:R:W416 37.78172YesNo047
23R:R:F396 R:R:L399 46.49162.44YesNo049
24R:R:I395 R:R:L399 47.33432.85NoNo059
25R:R:I395 R:R:T391 48.17193.04NoYes056
26R:R:F345 R:R:T391 43.92497.78YesYes096
27R:R:F345 R:R:H394 44.772713.58YesYes199
28R:R:H394 R:R:Y393 35.53098.71YesYes199
29L:L:R77 R:R:Y393 10022.64YesYes109
30R:R:C95 R:R:W88 14.31369.14NoYes099
31R:R:C172 R:R:C95 15.29777.28NoNo089
32R:R:C172 R:R:R161 16.27662.79NoYes088
33R:R:V419 R:R:W416 27.95417.36NoNo057
34R:R:L25 R:R:V419 27.01887.45NoNo055
35R:R:I29 R:R:L25 26.08364.28NoNo075
36R:R:A422 R:R:I29 25.14843.25NoNo087
37R:R:A422 R:R:L30 23.16233.15NoYes486
38R:R:L30 R:R:S425 18.77393YesNo068
39R:R:L75 R:R:S425 17.77453YesNo098
40R:R:W390 R:R:Y393 71.90213.86YesYes199
41R:R:N427 R:R:W390 59.80839.04YesYes199
42R:R:N427 R:R:N431 61.8156.81YesYes199
43R:R:D68 R:R:N431 32.91810.77YesYes199
44R:R:D68 R:R:N41 35.05566.73YesNo099
45R:R:N41 R:R:P432 25.7478.15NoNo099
46R:R:P432 R:R:V44 24.66023.53NoYes099
47R:R:F442 R:R:V44 21.79549.18YesYes399
48R:R:F442 R:R:V47 15.87326.55YesYes398
49R:R:L64 R:R:N431 12.92366.87YesYes199
50R:R:L112 R:R:L64 15.13322.77NoYes099
51R:R:N431 R:R:Y435 23.02615.81YesYes199
52R:R:I116 R:R:Y435 15.75763.63NoYes099
53R:R:I116 R:R:W60 21.72865.87NoYes098
54R:R:D119 R:R:W60 11.299810.05NoYes098
55R:R:D119 R:R:R134 10.200111.91NoYes099
56R:R:C154 R:R:V103 10.46483.42NoYes085
57R:R:R340 R:R:Y393 22.64843.09YesYes199
58R:R:F386 R:R:W390 18.37577.02YesYes199
59R:R:F386 R:R:M352 15.25658.71YesNo098
60R:R:M352 R:R:S117 14.66054.6NoNo089
61R:R:S117 R:R:Y356 12.25567.63NoYes099
62R:R:C355 R:R:S117 13.08295.16NoNo099
63R:R:C121 R:R:C355 11.9197.28NoNo099
64R:R:C121 R:R:F358 10.754.19NoNo096
65R:R:L387 R:R:T391 16.41792.95NoYes066
66R:R:L387 R:R:V383 14.28022.98NoNo068
67R:R:V382 R:R:Y435 11.99873.79NoYes089
68L:L:K11 L:L:Y59 15.526315.53YesNo000
69L:L:Q66 R:R:F164 41.22454.68YesYes803
70R:R:E162 R:R:K175 41.14495.4NoNo855
71R:R:H394 R:R:W390 13.06243.17YesYes199
72R:R:V383 R:R:Y356 13.74323.79NoYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Q3 R:R:T165 2.83 0 Yes No 0 4 0 1
L:L:Q3 R:R:D167 6.53 0 Yes No 0 3 0 1
L:L:R33 R:R:E406 9.3 0 No No 0 1 0 1
L:L:R65 R:R:D404 16.68 0 No No 0 4 0 1
L:L:Q66 R:R:F164 4.68 8 Yes Yes 0 3 0 1
L:L:Q66 R:R:K175 5.42 8 Yes No 0 5 0 1
L:L:H67 R:R:F164 9.05 0 Yes Yes 0 3 0 1
L:L:H67 R:R:T166 5.48 0 Yes No 0 1 0 1
L:L:R69 R:R:P405 4.32 0 No No 0 4 0 1
L:L:A70 R:R:F164 4.16 0 No Yes 0 3 0 1
L:L:H72 R:R:M414 5.25 0 No No 0 2 0 1
L:L:G74 R:R:H418 3.18 0 No No 0 4 0 1
L:L:L75 R:R:H81 12.86 5 No No 0 7 0 1
L:L:L75 R:R:W88 3.42 5 No Yes 0 9 0 1
L:L:A76 R:R:I421 4.87 0 No No 0 4 0 1
L:L:R77 R:R:R161 3.2 1 Yes Yes 0 8 0 1
L:L:R77 R:R:Y174 3.09 1 Yes Yes 0 7 0 1
L:L:R77 R:R:Y393 22.64 1 Yes Yes 0 9 0 1
L:L:R77 R:R:G397 6 1 Yes No 0 8 0 1
L:L:R77 R:R:D417 19.06 1 Yes No 0 8 0 1
L:L:R77 R:R:I421 3.76 1 Yes No 0 4 0 1
R:R:L82 R:R:S26 7.51 4 No Yes 7 8 2 2
R:R:H418 R:R:S26 2.79 4 No Yes 4 8 1 2
R:R:G86 R:R:H81 4.77 0 No No 7 7 2 1
R:R:H81 R:R:W88 5.29 5 No Yes 7 9 1 1
R:R:H418 R:R:L82 5.14 4 No No 4 7 1 2
R:R:P89 R:R:W88 2.7 5 No Yes 8 9 2 1
R:R:W88 R:R:Y90 9.65 5 Yes Yes 9 7 1 2
R:R:C95 R:R:W88 9.14 0 No Yes 9 9 2 1
R:R:P89 R:R:Y90 5.56 5 No Yes 8 7 2 2
R:R:C172 R:R:C95 7.28 0 No No 8 9 2 2
R:R:K96 R:R:R161 2.48 0 No Yes 8 8 2 1
R:R:P99 R:R:R161 8.65 0 No Yes 8 8 2 1
R:R:V157 R:R:Y174 3.79 0 No Yes 9 7 2 1
R:R:C172 R:R:R161 2.79 0 No Yes 8 8 2 1
R:R:R161 R:R:Y174 19.55 1 Yes Yes 8 7 1 1
R:R:E162 R:R:F164 3.5 8 No Yes 5 3 2 1
R:R:E162 R:R:K175 5.4 8 No No 5 5 2 1
R:R:F164 R:R:K175 3.72 8 Yes No 3 5 1 1
R:R:N170 R:R:T165 4.39 0 No No 4 4 2 1
R:R:L333 R:R:Y174 10.55 0 No Yes 3 7 2 1
R:R:R340 R:R:Y393 3.09 1 Yes Yes 9 9 2 1
R:R:W390 R:R:Y393 3.86 1 Yes Yes 9 9 2 1
R:R:H394 R:R:W390 3.17 1 Yes Yes 9 9 2 2
R:R:H394 R:R:Y393 8.71 1 Yes Yes 9 9 2 1
R:R:D404 R:R:P405 4.83 0 No No 4 4 1 1
R:R:D404 R:R:E406 2.6 0 No No 4 1 1 1
R:R:D417 R:R:I421 2.8 1 No No 8 4 1 1
L:L:L73 R:R:G173 1.71 0 No No 0 1 0 1
R:R:M414 R:R:P405 1.68 0 No No 2 4 1 1
L:L:L75 R:R:S78 1.5 5 No No 0 8 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8HK2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.48
Number of Linked Nodes 336
Number of Links 381
Number of Hubs 55
Number of Links mediated by Hubs 208
Number of Communities 11
Number of Nodes involved in Communities 76
Number of Links involved in Communities 102
Path Summary
Number Of Nodes in MetaPath 73
Number Of Links MetaPath 72
Number of Shortest Paths 80129
Length Of Smallest Path 3
Average Path Length 16.5453
Length of Longest Path 41
Minimum Path Strength 1.155
Average Path Strength 5.97895
Maximum Path Strength 20.85
Minimum Path Correlation 0.7
Average Path Correlation 0.950804
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 55.9434
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.1117
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8HK2_nogp_Chain_R
WNEPPVILS MVILSLTFL LGLPGNGLV LWVAGLKMQ RTVNTIWFL 
HLTLADLLC CLSLPFSLA HLALQGQWP YGRFLCKLI PSIIVLNMF 
ASVFLLTAI SLDRCLVVF KPIWCQNHR NVGMACSIC GCIWVVAFV 
MCIPVFVYR EIFTTDNHN RCGYKVPTP LVAITITRL VVGFLLPSV 
IMIACYSFI VFRMQRGRF AKSQSKTFR VAVVVVAVF LVCWTPYHI 
FGVLSLLTD PETPLGKTL MSWDHVCIA LASANSCFN PFLYALLGK 
DFRKKARQS IQGIL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HK2_nogp.zip



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