Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P22 6.8254134
2R:R:L30 6.78754186
3R:R:T33 4.0525408
4R:R:N41 4.5075409
5R:R:V47 4.895408
6R:R:I59 3.84406
7R:R:W60 5.00333608
8R:R:L64 6.4665119
9R:R:D68 6.9965119
10R:R:L75 7.374189
11R:R:Q87 7.9075406
12R:R:W88 10.14254229
13R:R:I98 7.2485228
14R:R:T114 3.5525408
15R:R:I116 5.8154119
16R:R:S117 3.3825409
17R:R:R120 5.9025119
18R:R:V123 5.85754125
19R:R:R134 7.64754129
20R:R:W147 4.69409
21R:R:I336 4.265407
22R:R:T337 4.095407
23R:R:R340 5.70754239
24R:R:P348 4.005409
25R:R:Y356 5.2175409
26R:R:R367 5.316676146
27R:R:F386 5.94754249
28R:R:W390 6.094297249
29R:R:T403 5.74162
30R:R:L413 6.6545167
31R:R:W416 5.8685137
32R:R:N431 9.55754119
33R:R:Y435 6.7325119
34R:R:F442 6.075199
35R:R:K445 6.045407
36A:A:V34 5.8465104
37A:A:L38 5.22498
38A:A:K46 3.3375499
39A:A:T48 2.922509
40A:A:I49 3.7325497
41A:A:L195 4.92754104
42A:A:F197 7.113336107
43A:A:R198 10.086516
44A:A:F200 9.354516
45A:A:Q205 4.566519
46A:A:K211 6.055619
47A:A:W212 5.03833619
48A:A:F216 5.46571719
49A:A:D227 8.7654178
50A:A:F251 8.302867269
51A:A:F259 8.3375404
52A:A:F260 6.514519
53A:A:T263 4.26418
54A:A:L267 5.064269
55A:A:F268 4.838599
56A:A:L269 5.2975408
57A:A:N270 4.5825499
58A:A:K271 6.9485179
59A:A:F275 6.5645278
60A:A:P283 4.28405
61A:A:F308 6.625268
62A:A:Y320 7.3365148
63A:A:T324 8.9775499
64A:A:Q333 4.114105
65A:A:F336 5.847108
66A:A:V339 4.7254108
67A:A:I342 4.9675406
68A:A:L348 4.3875408
69A:A:R349 6.444144
70A:A:Y354 9.5025405
71B:B:L4 2.3925404
72B:B:L14 5.11408
73B:B:I18 4.075427
74B:B:R22 6.396526
75B:B:V40 4.87167653
76B:B:L51 7.88439
77B:B:H54 9.67333639
78B:B:Y59 8.912518
79B:B:M61 8.2725436
80B:B:W63 7.186537
81B:B:R68 10.36254315
82B:B:L70 9.4025435
83B:B:D76 6.212539
84B:B:K78 6.6125408
85B:B:I80 9.0875438
86B:B:I81 4.56167677
87B:B:W82 7.85875839
88B:B:K89 6.64539
89B:B:H91 4.436575
90B:B:L95 6.234578
91B:B:W99 7.37857719
92B:B:Y105 4.47876
93B:B:N110 7.91444
94B:B:Y111 5.976544
95B:B:I123 4.84333646
96B:B:Y124 5.18576
97B:B:L126 4.12575
98B:B:V133 5.79474
99B:B:H142 8.586549
100B:B:Y145 6.20286718
101B:B:C149 3.46333648
102B:B:F151 4.89833649
103B:B:Q156 8.6075405
104B:B:I157 4.62447
105B:B:T159 4.31167649
106B:B:S160 5.1975486
107B:B:D163 8.038549
108B:B:C166 4.076588
109B:B:W169 8.09667648
110B:B:F180 6.872587
111B:B:H183 9.126589
112B:B:D186 5.686519
113B:B:V187 7.28489
114B:B:M188 4.115418
115B:B:L190 5.6375485
116B:B:F199 8.81589
117B:B:V200 5.93426
118B:B:S201 5.834589
119B:B:C204 5.9275417
120B:B:D205 7.1525409
121B:B:K209 6.642586
122B:B:L210 5.0625425
123B:B:W211 8.31167688
124B:B:Q220 7.178527
125B:B:F222 7.2425428
126B:B:H225 8.12333629
127B:B:I232 5.61528
128B:B:F234 5.92405
129B:B:F235 8.10571756
130B:B:N237 6.434555
131B:B:F241 6.03286726
132B:B:T243 6.96528
133B:B:T249 4.755426
134B:B:R251 10.1225428
135B:B:F253 7.96526
136B:B:R256 10.05459
137B:B:D258 11.6025427
138B:B:Q259 4.525406
139B:B:M262 3.3775404
140B:B:Y264 7.3125405
141B:B:R283 7.74559
142B:B:L285 6.29406
143B:B:Y289 8.6156157
144B:B:C294 4.016565
145B:B:N295 10.84254156
146B:B:W297 9.994158
147B:B:D298 8.93459
148B:B:V307 4.0254153
149B:B:H311 8.892569
150B:B:L318 4.30571766
151B:B:M325 5.775405
152B:B:V327 3.7975466
153B:B:T329 6.2075468
154B:B:W332 7.93833619
155B:B:D333 6.4175469
156B:B:F335 6.12404
157B:B:L336 4.9675437
158B:B:K337 10.185466
159B:B:W339 9.416569
160G:G:L19 3.108529
161G:G:E22 5.255429
162G:G:L37 4.395457
163G:G:Y40 8.24456
164G:G:D48 8.0275409
165G:G:F61 5.8075438
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:V419 R:R:W416 16.99043.68NoYes057
2R:R:L25 R:R:V419 16.38624.47NoNo055
3R:R:I29 R:R:L25 15.78197.14NoNo075
4R:R:A422 R:R:I29 15.17743.25NoNo087
5R:R:A422 R:R:L30 12.75723.15NoYes086
6R:R:F396 R:R:W416 21.2145.01NoYes047
7R:R:C420 R:R:F396 27.2314.19NoNo064
8R:R:C420 R:R:Y393 27.83164.03NoNo069
9R:R:W390 R:R:Y393 29.63234.82YesNo099
10R:R:F386 R:R:W390 22.38825.01YesYes2499
11R:R:F386 R:R:M352 24.148311.2YesNo098
12R:R:M352 R:R:S117 24.33593.07NoYes089
13R:R:S117 R:R:Y356 26.49863.82YesYes099
14R:R:R120 R:R:Y356 27.25549.26YesYes099
15A:A:L353 R:R:R120 87.12073.64NoYes069
16A:A:L348 A:A:L353 87.57294.15YesNo086
17A:A:L348 A:A:Y354 89.06764.69YesYes085
18A:A:Y354 R:R:F368 87.86989.28YesNo055
19A:A:I344 R:R:F368 88.18115.02NoNo075
20A:A:I344 R:R:P127 89.03915.08NoNo079
21A:A:I343 R:R:P127 89.18193.39NoNo089
22A:A:I343 A:A:V339 89.46193.07NoYes088
23A:A:L36 A:A:V339 92.59724.47NoYes1078
24A:A:I223 A:A:L36 98.54395.71NoNo077
25A:A:I223 A:A:L38 49.39624.28NoYes078
26A:A:K46 A:A:L38 49.53744.23YesYes998
27A:A:C225 A:A:K46 49.84743.23NoYes979
28A:A:C225 A:A:I49 49.8813.27NoYes977
29A:A:I49 A:A:T48 99.53513.04YesYes079
30A:A:G45 A:A:T48 99.4795.46NoYes099
31A:A:G45 A:A:K271 99.46443.49NoYes099
32A:A:K271 A:A:L274 99.20164.23YesNo1796
33A:A:D273 A:A:L274 1006.79NoNo096
34A:A:C325 A:A:D273 99.96414.67NoNo079
35A:A:C325 A:A:K272 99.927412.93NoNo075
36A:A:K272 A:A:Y297 99.908710.75NoNo053
37A:A:F275 A:A:Y297 99.85163.09YesNo083
38A:A:F275 A:A:L228 98.65488.53YesNo2787
39A:A:L228 A:A:L269 98.71896.92NoYes078
40A:A:L267 A:A:L269 97.87364.15YesYes098
41A:A:F251 A:A:L267 97.46146.09YesYes2699
42A:A:F224 A:A:F251 98.039617.15NoYes099
43A:A:F224 A:A:L250 97.97966.09NoNo099
44A:A:L250 A:A:R209 97.94923.64NoNo099
45A:A:L39 A:A:R209 97.91943.64NoNo099
46A:A:L37 A:A:L39 85.28355.54NoNo099
47A:A:F216 A:A:L37 85.25099.74YesNo099
48A:A:C215 A:A:F216 44.784.19NoYes169
49A:A:C215 B:B:Y59 44.53514.03NoYes168
50B:B:W332 B:B:Y59 45.30387.72YesYes198
51B:B:S316 B:B:W332 46.06014.94NoYes099
52B:B:C317 B:B:S316 45.93673.44NoNo079
53B:B:C317 B:B:M61 45.69433.24NoYes076
54B:B:M61 B:B:W63 34.21075.82YesYes367
55B:B:T321 B:B:W63 34.66299.7NoYes377
56B:B:D323 B:B:T321 34.33837.23NoNo377
57B:B:D323 B:B:M325 34.43968.32NoYes075
58B:B:M325 G:G:P49 47.84245.03YesNo057
59G:G:D48 G:G:P49 47.40934.83YesNo097
60B:B:S279 G:G:D48 36.73638.83NoYes099
61B:B:S279 G:G:L50 36.5666.01NoNo099
62B:B:M45 G:G:L50 36.39575.65NoNo049
63B:B:L308 B:B:M45 29.61147.07NoNo074
64B:B:C294 B:B:L308 16.34454.76YesNo057
65B:B:C294 B:B:V315 10.62565.12YesNo657
66B:B:D333 B:B:H311 30.53545.04YesYes699
67B:B:D312 B:B:D333 30.49593.99NoYes059
68B:B:D312 R:R:K445 29.22746.91NoYes057
69R:R:K445 R:R:V47 20.34563.04YesYes078
70R:R:F442 R:R:V47 12.721911.8YesYes098
71R:R:N427 R:R:W390 45.79127.91NoYes099
72R:R:N427 R:R:N431 46.95486.81NoYes099
73R:R:L64 R:R:N431 23.664310.98YesYes1199
74R:R:L64 R:R:Y435 27.31233.52YesYes1199
75R:R:R120 R:R:Y435 50.56216.17YesYes1199
76R:R:L113 R:R:N431 23.548512.36NoYes1189
77R:R:L113 R:R:Y435 23.735211.72NoYes1189
78A:A:I223 A:A:I335 49.29284.42NoNo078
79A:A:F268 A:A:I335 49.33145.02YesNo098
80A:A:F268 A:A:N270 49.33793.62YesYes999
81A:A:I49 A:A:N270 49.69414.25YesYes979
82B:B:H311 B:B:T329 21.24116.85YesYes698
83B:B:L308 B:B:W339 13.106919.36NoYes079
84B:B:L318 B:B:T329 11.28364.42YesYes668
85G:G:D48 G:G:L51 10.43428.14YesNo096
86R:R:M106 R:R:W390 36.21688.14NoYes099
87R:R:F107 R:R:M106 35.62182.49NoNo089
88R:R:F107 R:R:R340 33.8168.55NoYes2389
89R:R:R340 R:R:V157 23.02112.62YesNo099
90R:R:S100 R:R:V157 20.61123.23NoNo089
91R:R:F158 R:R:S100 20.00822.64NoNo088
92R:R:F158 R:R:K96 19.40516.2NoNo088
93R:R:K96 R:R:R161 15.781921.04NoNo088
94R:R:C95 R:R:R161 13.96535.57NoNo098
95R:R:C95 R:R:W88 12.75727.84NoYes099
96R:R:I336 R:R:R340 10.33392.51YesYes079
97B:B:H62 B:B:Y105 19.34783.27NoYes066
98B:B:H62 B:B:R150 19.47813.54NoNo066
99B:B:C148 B:B:R150 19.87224.18NoNo066
100B:B:C148 B:B:L190 20.18574.76NoYes065
101B:B:L190 B:B:S160 10.02516.01YesYes856
102B:B:S147 B:B:S160 34.84883.26NoYes096
103B:B:M188 B:B:S147 34.91763.07YesNo089
104A:A:K211 B:B:M188 34.65974.32YesYes198
105A:A:K211 B:B:Y145 35.38833.58YesYes198
106A:A:W212 B:B:Y145 36.41953.86YesYes198
107A:A:F216 A:A:W212 41.52484.01YesYes199
108A:A:I254 A:A:L39 12.61174.28NoNo089
109A:A:F260 A:A:I254 12.61235.02YesNo098
110A:A:F260 A:A:N257 12.30567.25YesNo198
111A:A:F259 A:A:N257 14.43293.62YesNo048
112A:A:F259 A:A:K258 13.521213.65YesNo044
113A:A:K258 B:B:R314 13.34453.71NoNo048
114B:B:S160 B:B:V187 20.5378.08YesYes869
115B:B:H225 B:B:I229 13.05889.28YesNo297
116B:B:G202 B:B:I229 18.55385.29NoNo067
117B:B:G202 B:B:S201 29.86793.71NoYes069
118B:B:C166 B:B:S201 15.62833.44YesYes889
119B:B:C166 B:B:S160 16.10133.44YesYes886
120B:B:S201 B:B:V187 12.73744.85YesYes899
121B:B:W297 B:B:Y264 10.534913.5YesYes085
122B:B:W297 B:B:Y289 10.51318.68YesYes1587
123B:B:D291 B:B:Y289 12.444511.49NoYes087
124B:B:C271 B:B:D291 13.72174.67NoNo058
125B:B:C271 B:B:D290 13.86774.67NoNo056
126B:B:D290 B:B:R314 14.016129.78NoNo068
127B:B:M325 G:G:P60 15.71926.71YesNo059
128B:B:D66 B:B:R68 16.05673.57NoYes085
129B:B:R68 B:B:Y85 15.885518.52YesNo054
130B:B:D66 B:B:L69 16.06955.43NoNo085
131B:B:L69 B:B:Y105 15.51957.03NoYes756
132B:B:F199 B:B:L190 11.63597.31YesYes895
133B:B:G202 B:B:S189 10.87093.71NoNo067
134B:B:I232 B:B:S189 10.42966.19YesNo087
135B:B:Y85 G:G:P60 15.197615.3NoNo049
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8I97
Class A
SubFamily Peptide
Type Complement peptide
SubType C3A
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-10-18
D.O.I. 10.1016/j.cell.2023.09.020
Net Summary
Imin 3.04
Number of Linked Nodes 826
Number of Links 1006
Number of Hubs 165
Number of Links mediated by Hubs 609
Number of Communities 31
Number of Nodes involved in Communities 258
Number of Links involved in Communities 373
Path Summary
Number Of Nodes in MetaPath 136
Number Of Links MetaPath 135
Number of Shortest Paths 1540272
Length Of Smallest Path 3
Average Path Length 44.0795
Length of Longest Path 83
Minimum Path Strength 1.19
Average Path Strength 6.04334
Maximum Path Strength 17.225
Minimum Path Correlation 0.7
Average Path Correlation 0.981333
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 33.3108
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.6759
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8I97_Chain_R
NEPPVILSM VILSLTFLL GLPGNGLVL WVAGLKMQR TVNTIWFLH 
LTLADLLCC LSLPFSLAH LALQGQWPY GRFLCKLIP SIIVLNMFA 
SVFLLTAIS LDRCLVVFK PIWCQNHRN VGMACSICG CIWVVAFVM 
CIPVFVYRE IFTTDNHNR CGYTPLVAI TITRLVVGF LLPSVIMIA 
CYSFIVFRM QRGRFAKSQ SKTFRVAVV VVAVFLVCW TPYHIFGVL 
SLLTDPETP LGKTLMSWD HVCIALASA NSCFNPFLY ALLGKDFRK 
KARQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>8I97_Chain_A
SAEERAALE RSKAIEKNL KEDGISAAK DVKLLLLGA DNSGKSTIV 
KQMKITGIV ETHFTFKNL HFRLFDVGG QRSERKKWI HCFEDVTAI 
IFCVDLSDR MHESLMLFD SICNNKFFI DTSIILFLN KKDLFGEKI 
KKSPLTICF PEYTGPNTY EDAAAYIQA QFESKNRSP NKEIYCHMT 
CATDTNNAQ VIFDAVTDI IIANNLRGC GLY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8I97_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8I97_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement peptideC3aBHomo sapiensC3a anaphylatoxin-Gi1/&β;1/&γ;22.92023-05-1010.1038/s41589-023-01339-w
8HK3APeptideComplement peptideC3aBHomo sapiens--Gi1/&β;1/&γ;23.22023-05-1010.1038/s41589-023-01339-w
8I95APeptideComplement peptideC3aBHomo sapiensEP54-Go/&β;1/&γ;22.882023-10-1810.1016/j.cell.2023.09.020
8I9AAPeptideComplement peptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.572023-10-1810.1016/j.cell.2023.09.020
8I9LAPeptideComplement peptideC3aBHomo sapiensC3a anaphylatoxin-Go/&β;1/&γ;23.182023-10-1810.1016/j.cell.2023.09.020
8I9SAPeptideComplement peptideC3aBHomo sapiens--Go/&β;1/&γ;23.262023-10-1810.1016/j.cell.2023.09.020
8IA8APeptideComplement peptideC3aBHomo sapiensE7 peptide-Gi1/&β;1/&γ;22.862023-05-24To be published
8J6DAPeptideComplement peptideC3aBHomo sapiensEP141-Go/&β;1/&γ;23.12023-10-1810.1016/j.cell.2023.09.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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