Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.846584
2A:A:L38 5.22498
3A:A:K46 3.3375499
4A:A:T48 2.945409
5A:A:I49 3.7325497
6A:A:L195 4.9275484
7A:A:H196 9.36413
8A:A:F197 7.11333687
9A:A:R198 10.802516
10A:A:F200 9.354516
11A:A:Q205 4.566519
12A:A:K211 7.564519
13A:A:W212 5.03833619
14A:A:F216 5.46571719
15A:A:D227 7.66254168
16A:A:F251 8.302867179
17A:A:F259 8.3375404
18A:A:F260 6.514519
19A:A:L267 5.064179
20A:A:F268 4.336599
21A:A:L269 5.2975408
22A:A:N270 6.045499
23A:A:K271 6.035169
24A:A:F275 6.5645188
25A:A:P283 4.28405
26A:A:F308 6.625178
27A:A:Y320 7.3365148
28A:A:Q333 4.11485
29A:A:F336 5.84788
30A:A:V339 4.725488
31A:A:L353 3.43406
32A:A:Y354 9.5025405
33B:B:L14 5.815408
34B:B:I18 3.09254217
35B:B:R19 4.82754214
36B:B:V40 4.924543
37B:B:M45 5.7625404
38B:B:L51 7.88439
39B:B:H54 8.45539
40B:B:Y59 8.912518
41B:B:M61 7.718536
42B:B:W63 7.636537
43B:B:R68 10.36254235
44B:B:S72 4.9075439
45B:B:K78 5.23408
46B:B:L79 4.81557
47B:B:I81 7.4475457
48B:B:W82 10.3257739
49B:B:T86 4.5954236
50B:B:K89 8.344539
51B:B:H91 4.17555
52B:B:L95 5.404558
53B:B:W99 7.37857719
54B:B:C103 3.4458
55B:B:Y105 4.92375856
56B:B:N110 7.91424
57B:B:Y111 5.976524
58B:B:I123 5.016526
59B:B:Y124 5.18556
60B:B:L126 4.08455
61B:B:V133 5.79454
62B:B:H142 9.356529
63B:B:Y145 6.20286718
64B:B:C149 3.46333628
65B:B:F151 5.124529
66B:B:Q156 8.6075405
67B:B:T159 4.31167629
68B:B:S160 5.1975466
69B:B:D163 8.038529
70B:B:C166 4.076568
71B:B:W169 8.09667628
72B:B:F180 6.872567
73B:B:H183 8.85569
74B:B:D186 5.686519
75B:B:V187 6.53469
76B:B:L190 5.6375465
77B:B:F199 8.965669
78B:B:V200 5.93476
79B:B:S201 5.51569
80B:B:C204 6.3175417
81B:B:D205 7.1525409
82B:B:K209 6.642566
83B:B:L210 5.0625475
84B:B:W211 8.31167668
85B:B:Q220 7.452577
86B:B:F222 7.2425478
87B:B:H225 8.81167679
88B:B:I229 8.6175477
89B:B:I232 5.914578
90B:B:F234 5.338505
91B:B:F235 6.83833646
92B:B:F241 6.17333676
93B:B:T243 9.3375478
94B:B:T249 4.755476
95B:B:R251 10.1225478
96B:B:F253 7.442576
97B:B:D254 4.6125409
98B:B:R256 8.7545249
99B:B:Q259 5.4025406
100B:B:Y264 6.384505
101B:B:R283 7.74549
102B:B:L284 4.3425445
103B:B:L285 5.926506
104B:B:L286 5.8275447
105B:B:Y289 8.045157
106B:B:D290 5.595406
107B:B:C294 4.2275405
108B:B:N295 10.84254156
109B:B:W297 9.994158
110B:B:D298 8.93449
111B:B:V307 4.224153
112B:B:H311 8.8925109
113B:B:R314 6.11418
114B:B:M325 5.775405
115B:B:W332 8.28167619
116B:B:D333 6.41754109
117B:B:F335 6.12404
118B:B:L336 5.742537
119B:B:K337 10.1854106
120B:B:W339 9.4165109
121G:G:L19 3.52754209
122G:G:Y40 9.1125446
123G:G:H44 7.7075406
124G:G:D48 7.29409
125G:G:F61 5.8075438
126R:R:L30 6.78754266
127R:R:T33 4.0525408
128R:R:N41 4.5075409
129R:R:V47 5.65254138
130R:R:I59 3.84406
131R:R:W60 5.00333608
132R:R:L64 6.4665129
133R:R:D68 6.9965129
134R:R:L75 7.374269
135R:R:W88 6.3275409
136R:R:I98 8.574288
137R:R:F107 5.29754298
138R:R:T114 3.5525408
139R:R:I116 5.8154129
140R:R:S117 3.3825409
141R:R:R120 5.9025129
142R:R:V123 5.85754115
143R:R:R134 7.64754119
144R:R:W147 4.69409
145R:R:I336 4.265407
146R:R:T337 4.095407
147R:R:R340 5.70754299
148R:R:P348 4.005409
149R:R:Y356 5.2175409
150R:R:R367 5.316676146
151R:R:F386 5.94754309
152R:R:W390 6.094297309
153R:R:L413 6.36507
154R:R:W416 5.8685257
155R:R:N431 9.55754129
156R:R:Y435 6.7325129
157R:R:F442 6.075139
158R:R:K445 6.5525137
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 69.40093.57NoYes085
2B:B:D66 B:B:L69 69.5445.43NoNo085
3B:B:L69 B:B:Y105 68.97917.03NoYes556
4R:R:I116 R:R:W60 10.69583.52YesYes098
5R:R:I116 R:R:R120 10.04156.26YesYes1299
6A:A:L353 R:R:R120 94.06283.64YesYes069
7A:A:L348 A:A:L353 96.14744.15NoYes086
8A:A:L348 A:A:Y354 96.46484.69NoYes085
9A:A:Y354 R:R:F368 95.86639.28YesNo055
10A:A:I344 R:R:F368 95.22335.02NoNo075
11A:A:I344 R:R:P127 96.13525.08NoNo079
12A:A:I343 R:R:P127 96.28693.39NoNo089
13A:A:I343 A:A:V339 96.17913.07NoYes088
14A:A:L36 A:A:V339 47.74854.47NoYes878
15A:A:I223 A:A:L36 47.83955.71NoNo077
16A:A:I223 A:A:L38 47.88224.28NoYes078
17A:A:K46 A:A:L38 47.97754.23YesYes998
18A:A:C225 A:A:K46 48.30373.23NoYes979
19A:A:C225 A:A:I49 48.33253.27NoYes977
20A:A:I49 A:A:T48 99.51433.04YesYes079
21A:A:G45 A:A:T48 99.4795.46NoYes099
22A:A:G45 A:A:K271 99.46673.49NoYes099
23A:A:K271 A:A:L274 99.23484.23YesNo1696
24A:A:D273 A:A:L274 1006.79NoNo096
25A:A:C325 A:A:D273 99.96854.67NoNo079
26A:A:C325 A:A:K272 99.93619.7NoNo075
27A:A:K272 A:A:Y297 99.919610.75NoNo053
28A:A:F275 A:A:Y297 99.90293.09YesNo083
29A:A:F275 A:A:L228 98.75478.53YesNo1887
30A:A:L228 A:A:L269 98.82676.92NoYes078
31A:A:L267 A:A:L269 98.0664.15YesYes098
32A:A:F251 A:A:L267 97.64256.09YesYes1799
33A:A:F251 A:A:I265 95.132511.3YesNo096
34A:A:I222 A:A:I265 95.14.42NoNo076
35A:A:F260 A:A:I222 94.82728.79YesNo197
36A:A:F260 A:A:I213 91.55775.02YesNo198
37A:A:I213 A:A:W212 91.92444.7NoYes189
38A:A:W212 B:B:Y145 84.28313.86YesYes198
39A:A:K211 B:B:Y145 84.50353.58YesYes198
40A:A:K211 B:B:M188 84.65177.2YesNo198
41B:B:M188 B:B:S147 85.11213.07NoNo089
42B:B:S147 B:B:S160 85.05923.26NoYes096
43B:B:L190 B:B:S160 63.58316.01YesYes656
44B:B:C148 B:B:L190 74.34874.76NoYes065
45B:B:C148 B:B:R150 74.58014.18NoNo066
46B:B:H62 B:B:R150 74.44713.54NoNo066
47B:B:H62 B:B:Y105 74.31443.27NoYes066
48A:A:F197 A:A:V339 48.3946.55YesYes878
49A:A:F190 A:A:F197 50.741311.79NoYes087
50A:A:F190 A:A:I335 50.82942.51NoNo088
51A:A:F268 A:A:I335 50.87262.51YesNo098
52A:A:F268 A:A:N270 50.94033.62YesYes999
53A:A:I49 A:A:N270 51.21514.25YesYes979
54B:B:F199 B:B:L190 13.2067.31YesYes695
55B:B:C166 B:B:S160 16.50753.44YesYes686
56B:B:C166 B:B:S201 15.74513.44YesYes689
57B:B:G202 B:B:S201 30.44473.71NoYes069
58B:B:G202 B:B:S189 14.22833.71NoNo067
59B:B:I232 B:B:S189 13.74076.19YesNo087
60B:B:S160 B:B:V187 19.36868.08YesYes669
61B:B:S201 B:B:V187 12.27623.23YesYes699
62B:B:G202 B:B:I229 15.73315.29NoYes067
63B:B:R68 B:B:Y85 65.145918.52YesNo054
64B:B:Y85 G:G:P60 61.459715.3NoNo049
65B:B:M325 G:G:P60 60.69646.71YesNo059
66B:B:M325 G:G:P49 60.21045.03YesNo057
67G:G:D48 G:G:P49 59.73134.83YesNo097
68B:B:S281 G:G:D48 17.98387.36NoYes099
69B:B:S281 G:G:H44 17.77934.18NoYes096
70G:G:H44 G:G:Y40 17.169416.33YesYes066
71B:B:F235 G:G:Y40 14.66286.19YesYes466
72B:B:F235 B:B:F278 14.93699.65YesNo067
73B:B:W297 B:B:Y264 10.119613.5YesYes085
74B:B:S279 G:G:D48 34.24588.83NoYes099
75B:B:S279 G:G:L50 34.05796.01NoNo099
76B:B:M45 G:G:L50 33.87665.65YesNo049
77B:B:L308 B:B:M45 35.66297.07NoYes074
78B:B:L308 B:B:W339 15.743619.36NoYes079
79B:B:C294 B:B:L308 19.7324.76YesNo057
80B:B:C294 B:B:V315 12.81855.12YesNo057
81B:B:D333 B:B:H311 24.39235.04YesYes1099
82B:B:H311 B:B:T329 12.6126.85YesNo098
83B:B:D312 B:B:D333 26.30373.99NoYes059
84B:B:D312 R:R:K445 25.25418.3NoYes057
85R:R:R120 R:R:Y356 29.29149.26YesYes099
86R:R:S117 R:R:Y356 28.4723.82YesYes099
87R:R:M352 R:R:S117 26.12913.07NoYes089
88R:R:F386 R:R:M352 25.926411.2YesNo098
89R:R:F386 R:R:W390 24.0225.01YesYes3099
90R:R:W390 R:R:Y393 32.75934.82YesNo099
91R:R:C420 R:R:Y393 30.80924.03NoNo069
92R:R:C420 R:R:F396 30.15884.19NoNo064
93R:R:F396 R:R:W416 23.64225.01NoYes047
94R:R:V419 R:R:W416 20.37563.68NoYes057
95R:R:L25 R:R:V419 19.72164.47NoNo055
96R:R:I29 R:R:L25 19.06747.14NoNo075
97R:R:A422 R:R:I29 18.4133.25NoNo087
98R:R:R120 R:R:Y435 54.71916.17YesYes1299
99R:R:L64 R:R:Y435 29.7973.52YesYes1299
100R:R:L64 R:R:N431 25.416610.98YesYes1299
101R:R:N427 R:R:N431 50.45916.81NoYes099
102R:R:N427 R:R:W390 49.19937.91NoYes099
103R:R:L113 R:R:Y435 25.490311.72NoYes1289
104R:R:L113 R:R:N431 25.288812.36NoYes1289
105R:R:A422 R:R:L30 14.48193.15NoYes086
106R:R:K445 R:R:V47 16.84423.04YesYes1378
107R:R:F442 R:R:V47 14.747911.8YesYes1398
108R:R:M106 R:R:W390 37.9488.14NoYes099
109R:R:F107 R:R:M106 37.30162.49YesNo089
110R:R:F107 R:R:R340 31.44898.55YesYes2989
111R:R:R340 R:R:V157 23.64222.62YesNo099
112R:R:S100 R:R:V157 11.85673.23NoNo089
113R:R:F158 R:R:S100 11.19992.64NoNo088
114R:R:F158 R:R:K96 10.542816.13NoNo088
115R:R:V157 R:R:Y174 11.19991.26NoNo097
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8I97
Class A
SubFamily Peptide
Type Complement Peptide
SubType C3A
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-10-18
D.O.I. doi.org/10.1016/j.cell.2023.09.020
Net Summary
Imin 3.04
Number of Linked Nodes 821
Number of Links 995
Number of Hubs 158
Number of Links mediated by Hubs 593
Number of Communities 31
Number of Nodes involved in Communities 250
Number of Links involved in Communities 356
Path Summary
Number Of Nodes in MetaPath 116
Number Of Links MetaPath 115
Number of Shortest Paths 1436269
Length Of Smallest Path 3
Average Path Length 44.4348
Length of Longest Path 87
Minimum Path Strength 1.19
Average Path Strength 6.02315
Maximum Path Strength 22.65
Minimum Path Correlation 0.7
Average Path Correlation 0.98091
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 33.2649
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.4773
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>8I97_Chain_A
SAEERAALE RSKAIEKNL KEDGISAAK DVKLLLLGA DNSGKSTIV 
KQMKITGIV ETHFTFKNL HFRLFDVGG QRSERKKWI HCFEDVTAI 
IFCVDLSDR MHESLMLFD SICNNKFFI DTSIILFLN KKDLFGEKI 
KKSPLTICF PEYTGPNTY EDAAAYIQA QFESKNRSP NKEIYCHMT 
CATDTNNAQ VIFDAVTDI IIANNLRGC GLY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8I97_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8I97_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8I97_Chain_R
NEPPVILSM VILSLTFLL GLPGNGLVL WVAGLKMQR TVNTIWFLH 
LTLADLLCC LSLPFSLAH LALQGQWPY GRFLCKLIP SIIVLNMFA 
SVFLLTAIS LDRCLVVFK PIWCQNHRN VGMACSICG CIWVVAFVM 
CIPVFVYRE IFTTDNHNR CGYTPLVAI TITRLVVGF LLPSVIMIA 
CYSFIVFRM QRGRFAKSQ SKTFRVAVV VVAVFLVCW TPYHIFGVL 
SLLTDPETP LGKTLMSWD HVCIALASA NSCFNPFLY ALLGKDFRK 
KARQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I97.zip



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