psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S1	L:L:V2	3.23	No	No	0	0	0
2	L:L:Q3	L:L:S1	4.33	No	No	7	0	0
3	L:L:L4	L:L:S1	6.01	Yes	No	7	0	0
4	L:L:L4	L:L:Q3	3.99	Yes	No	7	0	0
5	L:L:L4	L:L:R8	4.86	Yes	No	0	0	0
6	L:L:K7	L:L:L63	5.64	No	No	0	0	0
7	L:L:C23	L:L:K11	6.47	No	Yes	5	0	0
8	L:L:C56	L:L:K11	6.47	No	Yes	5	0	0
9	L:L:K11	L:L:Y59	17.91	Yes	No	0	0	0
10	L:L:I60	L:L:K11	8.72	No	Yes	0	0	0
11	L:L:G13	L:L:V12	3.68	No	No	0	0	0
12	L:L:E24	L:L:V12	9.98	No	No	0	0	0
13	L:L:G13	L:L:L19	5.13	No	No	0	0	0
14	L:L:P16	L:L:Y15	18.08	No	No	0	0	0
15	L:L:V52	L:L:Y15	16.4	Yes	No	0	0	0
16	L:L:E18	L:L:K17	13.5	No	No	0	0	0
17	L:L:C22	L:L:C49	7.28	No	No	0	0	0
18	L:L:C23	L:L:C56	7.28	No	No	5	0	0
19	L:L:F34	L:L:R38	4.28	No	No	0	0	0
20	L:L:C36	L:L:T40	3.38	Yes	No	0	0	0
21	L:L:C36	L:L:F53	5.59	Yes	Yes	8	0	0
22	L:L:C36	L:L:L54	3.17	Yes	No	0	0	0
23	L:L:C36	L:L:C57	7.28	Yes	No	8	0	0
24	L:L:F42	L:L:R39	11.76	No	No	0	0	0
25	L:L:F53	L:L:R39	8.55	Yes	No	0	0	0
26	L:L:C49	L:L:L45	3.17	No	No	0	0	0
27	L:L:E47	L:L:K51	6.75	No	No	0	0	0
28	L:L:C49	L:L:V52	3.42	No	Yes	0	0	0
29	L:L:C57	L:L:F53	6.98	No	Yes	8	0	0
30	L:L:L63	L:L:Y59	5.86	No	No	0	0	0
31	L:L:I60	L:L:R64	5.01	No	No	0	0	0
32	L:L:R65	L:L:R69	9.6	No	No	0	0	0
33	L:L:R65	R:R:P405	10.09	No	No	0	0	4
34	L:L:Q66	R:R:E162	3.82	No	No	9	0	5
35	L:L:Q66	R:R:F164	7.03	No	Yes	9	0	3
36	L:L:A70	R:R:F164	4.16	No	Yes	0	0	3
37	L:L:H72	L:L:S71	12.55	No	No	0	0	0
38	L:L:H72	R:R:Q85	17.31	No	No	0	0	5
39	L:L:H72	R:R:R171	19.18	No	Yes	0	0	1
40	L:L:L73	L:L:R77	6.07	No	Yes	0	0	0
41	L:L:G74	R:R:H418	3.18	No	Yes	0	0	4
42	L:L:L75	R:R:S78	6.01	Yes	No	0	0	8
43	L:L:L75	R:R:I98	8.56	Yes	Yes	2	0	8
44	L:L:L75	R:R:P99	9.85	Yes	No	2	0	8
45	L:L:L75	R:R:I102	4.28	Yes	No	0	0	8
46	L:L:A76	R:R:I421	6.5	No	No	0	0	4
47	L:L:R77	R:R:Y393	18.52	Yes	Yes	1	0	9
48	L:L:R77	R:R:G397	4.5	Yes	No	0	0	8
49	L:L:R77	R:R:D417	20.25	Yes	No	1	0	8
50	L:L:R77	R:R:I421	7.52	Yes	No	1	0	4
51	R:R:Q85	R:R:W18	5.48	No	No	0	5	1
52	R:R:E20	R:R:P22	7.86	No	Yes	10	4	4
53	R:R:E20	R:R:S415	4.31	No	No	10	4	5
54	R:R:P21	R:R:P22	5.84	No	Yes	0	6	4
55	R:R:P22	R:R:S415	3.56	Yes	No	10	4	5
56	R:R:P22	R:R:W416	17.57	Yes	Yes	0	4	7
57	R:R:L82	R:R:V23	8.94	No	No	0	7	4
58	R:R:I24	R:R:M27	7.29	No	No	0	7	6
59	R:R:I29	R:R:L25	5.71	No	No	0	7	5
60	R:R:L25	R:R:V419	5.96	No	No	0	5	5
61	R:R:H418	R:R:S26	4.18	Yes	No	0	4	8
62	R:R:A422	R:R:I29	3.25	No	No	0	8	7
63	R:R:L30	R:R:L75	4.15	No	No	0	6	9
64	R:R:C429	R:R:T33	5.07	No	No	0	9	8
65	R:R:F34	R:R:L75	6.09	No	No	0	7	9
66	R:R:F34	R:R:P76	7.22	No	No	0	7	9
67	R:R:C429	R:R:L36	4.76	No	No	0	9	8
68	R:R:F433	R:R:L36	4.87	No	No	0	6	8
69	R:R:G37	R:R:N41	3.39	No	Yes	0	9	9
70	R:R:C429	R:R:G37	3.92	No	No	0	9	9
71	R:R:L38	R:R:P39	3.28	No	No	0	7	7
72	R:R:G40	R:R:L43	5.13	No	No	0	9	8
73	R:R:D68	R:R:N41	6.73	Yes	Yes	0	9	9
74	R:R:C72	R:R:N41	4.72	No	Yes	0	8	9
75	R:R:N41	R:R:P432	6.52	Yes	No	0	9	9
76	R:R:L43	R:R:V44	4.47	No	Yes	0	8	9
77	R:R:T65	R:R:V44	3.17	No	Yes	0	9	9
78	R:R:P432	R:R:V44	5.3	No	Yes	0	9	9
79	R:R:A436	R:R:V44	3.39	No	Yes	4	8	9
80	R:R:F442	R:R:V44	5.24	Yes	Yes	4	9	9
81	R:R:L45	R:R:T65	8.84	No	No	0	8	9
82	R:R:L45	R:R:L66	4.15	No	No	0	8	4
83	R:R:L50	R:R:W46	6.83	No	No	0	4	6
84	R:R:S449	R:R:W46	3.71	No	No	0	9	6
85	R:R:K51	R:R:V47	4.55	No	Yes	4	9	8
86	R:R:F442	R:R:V47	9.18	Yes	Yes	4	9	8
87	R:R:S449	R:R:V47	3.23	No	Yes	4	9	8
88	R:R:K445	R:R:K51	24.42	No	No	0	7	9
89	R:R:K51	R:R:S449	6.12	No	No	4	9	9
90	R:R:M52	R:R:T58	7.53	No	No	0	9	8
91	R:R:D441	R:R:M52	5.54	No	No	0	7	9
92	R:R:N57	R:R:T55	8.77	No	No	0	8	9
93	R:R:T55	R:R:T58	4.71	No	No	0	9	8
94	R:R:R134	R:R:V56	7.85	Yes	No	0	9	8
95	R:R:A139	R:R:I59	3.25	No	No	0	7	6
96	R:R:C140	R:R:I59	3.27	No	No	0	4	6
97	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
98	R:R:I116	R:R:W60	3.52	No	Yes	0	9	8
99	R:R:D119	R:R:W60	4.47	No	Yes	0	9	8
100	R:R:A139	R:R:W60	5.19	No	Yes	0	7	8
101	R:R:I142	R:R:W60	7.05	No	Yes	0	5	8
102	R:R:F442	R:R:F61	3.22	Yes	No	0	9	8
103	R:R:H63	R:R:L112	3.86	No	No	0	8	9
104	R:R:C143	R:R:H63	16.22	No	No	0	8	8
105	R:R:H63	R:R:W147	7.41	No	Yes	0	8	9
106	R:R:D68	R:R:L64	8.14	Yes	Yes	3	9	9
107	R:R:L113	R:R:L64	5.54	No	Yes	3	8	9
108	R:R:L64	R:R:N431	6.87	Yes	Yes	3	9	9
109	R:R:L64	R:R:Y435	3.52	Yes	Yes	3	9	9
110	R:R:D68	R:R:S109	4.42	Yes	No	3	9	9
111	R:R:D68	R:R:S428	7.36	Yes	No	0	9	9
112	R:R:D68	R:R:N431	9.42	Yes	Yes	3	9	9
113	R:R:L70	R:R:N105	13.73	No	No	0	6	9
114	R:R:C71	R:R:M106	3.24	No	Yes	0	8	9
115	R:R:C71	R:R:S425	3.44	No	No	0	8	8
116	R:R:C71	R:R:S428	6.89	No	No	0	8	9
117	R:R:I102	R:R:S74	7.74	No	No	0	8	9
118	R:R:L75	R:R:S425	9.01	No	No	0	9	8
119	R:R:F77	R:R:I98	15.07	No	Yes	0	8	8
120	R:R:G86	R:R:H81	7.94	No	No	2	7	7
121	R:R:H81	R:R:W88	3.17	No	Yes	2	7	9
122	R:R:H81	R:R:R171	21.44	No	Yes	2	7	1
123	R:R:H418	R:R:L82	15.43	Yes	No	0	4	7
124	R:R:L84	R:R:Q87	6.65	No	No	0	8	6
125	R:R:G86	R:R:R171	9.01	No	Yes	2	7	1
126	R:R:H169	R:R:Q87	14.84	No	No	0	3	6
127	R:R:W88	R:R:Y90	11.58	Yes	Yes	2	9	7
128	R:R:L94	R:R:W88	3.42	No	Yes	2	8	9
129	R:R:C95	R:R:W88	9.14	Yes	Yes	2	9	9
130	R:R:I98	R:R:W88	9.4	Yes	Yes	2	8	9
131	R:R:C172	R:R:W88	10.45	No	Yes	2	8	9
132	R:R:P89	R:R:Y90	9.74	No	Yes	0	8	7
133	R:R:L94	R:R:Y90	8.21	No	Yes	2	8	7
134	R:R:K96	R:R:R92	6.19	No	No	0	8	1
135	R:R:I163	R:R:R92	5.01	Yes	No	0	6	1
136	R:R:C95	R:R:R161	4.18	Yes	Yes	0	9	8
137	R:R:C95	R:R:I163	3.27	Yes	Yes	2	9	6
138	R:R:C172	R:R:C95	7.28	No	Yes	2	8	9
139	R:R:F158	R:R:K96	11.17	No	No	0	8	8
140	R:R:K96	R:R:R161	3.71	No	Yes	0	8	8
141	R:R:F158	R:R:L97	3.65	No	No	0	8	6
142	R:R:I98	R:R:P99	8.47	Yes	No	2	8	8
143	R:R:P99	R:R:R161	11.53	No	Yes	0	8	8
144	R:R:C154	R:R:S100	5.16	No	No	0	8	8
145	R:R:F158	R:R:S100	10.57	No	No	0	8	8
146	R:R:I101	R:R:N105	7.08	No	No	0	5	9
147	R:R:I102	R:R:M106	4.37	No	Yes	0	8	9
148	R:R:F107	R:R:V103	5.24	Yes	No	1	8	5
149	R:R:R340	R:R:V103	7.85	No	No	1	9	5
150	R:R:L104	R:R:N105	4.12	No	No	0	8	9
151	R:R:L104	R:R:W147	5.69	No	Yes	0	8	9
152	R:R:C154	R:R:L104	3.17	No	No	0	8	8
153	R:R:M106	R:R:W390	9.31	Yes	Yes	1	9	9
154	R:R:M106	R:R:Y393	3.59	Yes	Yes	1	9	9
155	R:R:F107	R:R:M153	4.98	Yes	No	0	8	8
156	R:R:F107	R:R:R340	14.97	Yes	No	1	8	9
157	R:R:F107	R:R:W390	4.01	Yes	Yes	1	8	9
158	R:R:A108	R:R:W147	7.78	No	Yes	0	9	9
159	R:R:N431	R:R:S109	4.47	Yes	No	3	9	9
160	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
161	R:R:F386	R:R:V110	5.24	No	No	0	9	9
162	R:R:V110	R:R:W390	7.36	No	Yes	0	9	9
163	R:R:F111	R:R:I146	5.02	No	No	0	8	8
164	R:R:I146	R:R:L112	4.28	No	No	0	8	9
165	R:R:L113	R:R:N431	10.98	No	Yes	3	8	9
166	R:R:L113	R:R:Y435	10.55	No	Yes	3	8	9
167	R:R:P348	R:R:T114	3.5	Yes	No	0	9	8
168	R:R:I351	R:R:T114	4.56	No	No	0	6	8
169	R:R:I116	R:R:R120	6.26	No	No	3	9	9
170	R:R:I116	R:R:Y435	8.46	No	Yes	3	9	9
171	R:R:M352	R:R:S117	6.13	No	No	0	8	9
172	R:R:C355	R:R:S117	5.16	No	No	0	9	9
173	R:R:D119	R:R:V123	4.38	No	No	6	9	5
174	R:R:D119	R:R:R134	8.34	No	Yes	6	9	9
175	R:R:R120	R:R:Y356	8.23	No	Yes	0	9	9
176	R:R:R120	R:R:Y435	6.17	No	Yes	3	9	9
177	R:R:C121	R:R:F125	4.19	No	Yes	0	9	6
178	R:R:C121	R:R:C355	7.28	No	No	0	9	9
179	R:R:K126	R:R:L122	9.87	No	No	0	6	7
180	R:R:C130	R:R:L122	4.76	Yes	No	0	7	7
181	R:R:C130	R:R:V123	3.42	Yes	No	6	7	5
182	R:R:R134	R:R:V123	6.54	Yes	No	6	9	5
183	R:R:F125	R:R:V124	3.93	Yes	No	0	6	9
184	R:R:F125	R:R:F358	7.5	Yes	No	0	6	6
185	R:R:F125	R:R:R362	3.21	Yes	No	0	6	7
186	R:R:C130	R:R:W129	3.92	Yes	No	0	7	6
187	R:R:H133	R:R:W129	15.87	No	No	0	8	6
188	R:R:C130	R:R:R134	4.18	Yes	Yes	6	7	9
189	R:R:H133	R:R:N132	3.83	No	No	0	8	8
190	R:R:G137	R:R:N135	3.39	No	No	0	5	5
191	R:R:I142	R:R:M138	4.37	No	No	0	5	6
192	R:R:F151	R:R:I155	7.54	No	No	0	5	5
193	R:R:I155	R:R:P156	3.39	No	No	0	5	9
194	R:R:I336	R:R:P156	6.77	No	No	0	7	9
195	R:R:V157	R:R:Y174	5.05	No	Yes	0	9	7
196	R:R:V159	R:R:Y160	5.05	No	No	0	4	8
197	R:R:P332	R:R:Y160	6.95	No	No	0	4	8
198	R:R:R161	R:R:Y174	17.49	Yes	Yes	0	8	7
199	R:R:E162	R:R:F164	15.16	No	Yes	9	5	3
200	R:R:E162	R:R:Y174	4.49	No	Yes	0	5	7
201	R:R:I163	R:R:N170	5.66	Yes	No	0	6	4
202	R:R:C172	R:R:I163	8.18	No	Yes	2	8	6
203	R:R:N170	R:R:T166	5.85	No	No	0	4	1
204	R:R:D167	R:R:N168	5.39	No	No	0	3	5
205	R:R:H418	R:R:R171	3.39	Yes	Yes	0	4	1
206	R:R:P332	R:R:T331	3.5	No	No	0	4	4
207	R:R:L401	R:R:T337	4.42	No	No	0	7	7
208	R:R:R340	R:R:Y393	4.12	No	Yes	1	9	9
209	R:R:F345	R:R:L341	3.65	No	No	1	9	6
210	R:R:H394	R:R:L341	5.14	No	No	1	9	6
211	R:R:L346	R:R:V342	4.47	No	No	0	8	6
212	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
213	R:R:F345	R:R:T391	7.78	No	No	0	9	6
214	R:R:F345	R:R:H394	11.31	No	No	1	9	9
215	R:R:S349	R:R:V350	3.23	No	No	0	4	4
216	R:R:M352	R:R:Y356	3.59	No	Yes	0	8	9
217	R:R:F386	R:R:M352	3.73	No	No	0	9	8
218	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	9
219	R:R:V382	R:R:Y356	3.79	Yes	Yes	0	8	9
220	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
221	R:R:M363	R:R:V360	6.09	No	No	0	7	6
222	R:R:F376	R:R:V360	6.55	No	No	0	4	6
223	R:R:R362	R:R:R365	6.4	No	No	0	7	4
224	R:R:F368	R:R:R362	4.28	No	No	0	5	7
225	R:R:M363	R:R:Q372	13.59	No	No	0	7	5
226	R:R:M363	R:R:T375	9.03	No	No	0	7	7
227	R:R:Q364	R:R:Q372	7.68	No	No	0	5	5
228	R:R:F368	R:R:R367	4.28	No	No	0	5	6
229	R:R:S371	R:R:T375	3.2	No	No	0	7	7
230	R:R:K374	R:R:V378	4.55	No	No	0	9	8
231	R:R:R377	R:R:V380	6.54	No	No	0	5	3
232	R:R:L438	R:R:V378	7.45	No	No	0	7	8
233	R:R:V382	R:R:Y435	3.79	Yes	Yes	0	8	9
234	R:R:L434	R:R:V385	4.47	No	No	0	9	7
235	R:R:F386	R:R:N427	3.62	No	Yes	0	9	9
236	R:R:C389	R:R:N427	7.87	No	Yes	0	9	9
237	R:R:W390	R:R:Y393	9.65	Yes	Yes	1	9	9
238	R:R:H394	R:R:W390	8.46	No	Yes	1	9	9
239	R:R:A424	R:R:W390	5.19	No	Yes	1	9	9
240	R:R:N427	R:R:W390	9.04	Yes	Yes	0	9	9
241	R:R:P392	R:R:T391	3.5	No	No	0	9	6
242	R:R:I395	R:R:T391	4.56	No	No	0	5	6
243	R:R:A424	R:R:Y393	4	No	Yes	1	9	9
244	R:R:F396	R:R:L413	8.53	No	No	0	4	7
245	R:R:C420	R:R:F396	5.59	No	No	0	6	4
246	R:R:L413	R:R:S400	4.5	No	No	0	7	2
247	R:R:M414	R:R:S400	4.6	No	No	0	2	2
248	R:R:D404	R:R:P405	11.27	No	No	0	4	4
249	R:R:D404	R:R:T407	4.34	No	No	0	4	7
250	R:R:P408	R:R:T407	3.5	No	No	0	4	7
251	R:R:K411	R:R:P408	3.35	No	No	0	2	4
252	R:R:V419	R:R:W416	3.68	No	Yes	0	5	7
253	R:R:D417	R:R:I421	4.2	No	No	1	8	4
254	R:R:N427	R:R:N431	9.54	Yes	Yes	0	9	9
255	R:R:F433	R:R:L437	3.65	No	No	0	6	7
256	R:R:A436	R:R:F442	8.32	No	Yes	4	8	9
257	R:R:L437	R:R:R443	4.86	No	No	0	7	9
258	R:R:A422	R:R:L30	3.15	No	No	0	8	6
259	R:R:A48	R:R:L62	3.15	No	No	0	7	8
260	R:R:I353	R:R:V383	3.07	No	No	0	5	8
261	R:R:M27	R:R:V28	3.04	No	No	0	6	6
262	R:R:M52	R:R:V47	3.04	No	Yes	0	9	8
263	L:L:M9	L:L:T5	3.01	No	No	0	0	0
264	L:L:F53	L:L:G26	3.01	Yes	No	0	0	0
265	R:R:F164	R:R:G173	3.01	Yes	No	0	3	1
266	R:R:F396	R:R:W416	3.01	No	Yes	0	4	7
267	R:R:L387	R:R:S349	3	No	No	0	6	4
268	R:R:L401	R:R:V334	2.98	No	No	0	7	4
269	R:R:L341	R:R:V398	2.98	No	No	0	6	7
270	R:R:L434	R:R:V382	2.98	No	Yes	0	9	8
271	R:R:L387	R:R:V383	2.98	No	No	0	6	8
272	R:R:L413	R:R:T403	2.95	No	No	0	7	2
273	R:R:K440	R:R:K444	2.87	No	No	0	7	5
274	R:R:I351	R:R:L118	2.85	No	No	0	6	8
275	R:R:I395	R:R:L399	2.85	No	No	0	5	9
276	L:L:Q3	R:R:T166	2.83	No	No	0	0	1
277	R:R:C389	R:R:F430	2.79	No	No	0	9	7
278	L:L:D10	L:L:K7	2.77	No	No	0	0	0
279	R:R:L45	R:R:L69	2.77	No	No	0	8	7
280	R:R:A48	R:R:F442	2.77	No	Yes	0	7	9
281	R:R:L69	R:R:L73	2.77	No	No	0	7	8
282	R:R:A426	R:R:F430	2.77	No	No	0	8	7
283	L:L:E6	L:L:M9	2.71	No	No	0	0	0
284	R:R:K445	R:R:Q448	2.71	No	No	0	7	7
285	L:L:R20	L:L:V12	2.62	No	No	0	0	0
286	R:R:F111	R:R:V149	2.62	No	No	0	8	4
287	R:R:F111	R:R:V343	2.62	No	No	0	8	4
288	R:R:A67	R:R:W147	2.59	No	Yes	0	9	9
289	R:R:I450	R:R:R447	2.51	No	No	0	4	5
290	L:L:K21	L:L:R20	2.48	No	No	0	0	0
291	R:R:F34	R:R:L79	2.44	No	No	0	7	6
292	R:R:F93	R:R:L97	2.44	No	No	0	4	6
293	R:R:T412	R:R:W416	2.43	No	Yes	0	6	7
294	L:L:E62	L:L:R65	2.33	No	No	0	0	0
295	L:L:H67	R:R:F164	2.26	No	Yes	0	0	3
296	R:R:F361	R:R:R365	2.14	No	No	0	4	4
297	L:L:R38	L:L:R41	2.13	No	No	0	0	0
298	R:R:G40	R:R:P39	2.03	No	No	0	9	7
299	R:R:Y160	R:R:Y174	1.99	No	Yes	0	8	7
300	R:R:C140	R:R:G137	1.96	No	No	0	4	5
301	L:L:A68	R:R:P405	1.87	No	No	0	0	4
302	R:R:G137	R:R:V136	1.84	No	No	0	5	7
303	R:R:G410	R:R:T403	1.82	No	No	0	3	2
304	R:R:A108	R:R:A150	1.79	No	No	0	9	9
305	L:L:C23	L:L:V52	1.71	No	Yes	5	0	0
306	L:L:C56	L:L:V52	1.71	No	Yes	5	0	0
307	R:R:G42	R:R:L69	1.71	No	No	0	6	7
308	R:R:G49	R:R:L62	1.71	No	No	0	7	8
309	R:R:C389	R:R:V388	1.71	No	No	0	9	6
310	R:R:G410	R:R:L409	1.71	No	No	0	3	3
311	R:R:A446	R:R:V47	1.7	No	Yes	0	8	8
312	L:L:K17	L:L:P16	1.67	No	No	0	0	0
313	R:R:K126	R:R:P127	1.67	No	No	0	6	9
314	R:R:G86	R:R:Q87	1.64	No	No	0	7	6
315	R:R:C121	R:R:I359	1.64	No	No	0	9	9
316	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
317	R:R:L423	R:R:P392	1.64	No	No	0	8	9
318	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
319	R:R:V381	R:R:V382	1.6	No	Yes	0	7	8
320	R:R:T339	R:R:V343	1.59	No	No	0	8	4
321	R:R:I155	R:R:V159	1.54	No	No	0	5	4
322	R:R:I338	R:R:V334	1.54	No	No	0	6	4
323	R:R:I338	R:R:V342	1.54	No	No	0	6	6
324	L:L:I60	L:L:T61	1.52	No	No	0	0	0
325	R:R:I359	R:R:T375	1.52	No	No	0	9	7
326	R:R:A369	R:R:Q372	1.52	No	No	0	5	5
327	L:L:A48	L:L:E18	1.51	No	No	0	0	0
328	R:R:G366	R:R:R367	1.5	No	No	0	2	6
329	R:R:L32	R:R:V28	1.49	No	No	0	6	6
330	R:R:L347	R:R:V342	1.49	No	No	0	7	6
331	R:R:L402	R:R:V398	1.49	No	No	0	5	7
332	R:R:L409	R:R:T407	1.47	No	No	0	3	7
333	R:R:G91	R:R:Y90	1.45	No	Yes	0	9	7
334	R:R:D167	R:R:T166	1.45	No	No	0	3	1
335	L:L:Q37	L:L:S35	1.44	No	No	0	0	0
336	L:L:I43	L:L:L45	1.43	No	No	0	0	0
337	R:R:Q53	R:R:T55	1.42	No	No	0	6	9
338	R:R:I128	R:R:N132	1.42	No	No	0	7	8
339	L:L:K7	L:L:L4	1.41	No	Yes	0	0	0
340	R:R:K440	R:R:R443	1.24	No	No	0	7	9
341	L:L:R69	R:R:L333	1.21	No	No	0	0	3
342	L:L:L19	L:L:Y15	1.17	No	No	0	0	0
343	R:R:F376	R:R:R377	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L4	4.0675	4	7	0
2	L:L:K11	9.8925	4	5	0
3	L:L:C36	4.855	4	8	0
4	L:L:V52	5.81	4	5	0
5	L:L:F53	6.0325	4	8	0
6	L:L:L75	7.175	4	2	0
7	L:L:R77	11.372	5	1	0
8	R:R:P22	8.7075	4	10	4
9	R:R:N41	5.34	4	0	9
10	R:R:V44	4.314	5	4	9
11	R:R:V47	4.34	5	4	8
12	R:R:W60	4.824	5	0	8
13	R:R:L64	6.0175	4	3	9
14	R:R:D68	7.214	5	3	9
15	R:R:W88	7.86	6	2	9
16	R:R:Y90	7.745	4	2	7
17	R:R:C95	5.9675	4	2	9
18	R:R:I98	10.375	4	2	8
19	R:R:M106	5.1275	4	1	9
20	R:R:F107	7.3	4	1	8
21	R:R:F125	4.7075	4	0	6
22	R:R:C130	4.07	4	6	7
23	R:R:R134	6.7275	4	6	9
24	R:R:W147	5.8675	4	0	9
25	R:R:R161	9.2275	4	0	8
26	R:R:I163	5.53	4	2	6
27	R:R:F164	6.324	5	9	3
28	R:R:R171	13.255	4	2	1
29	R:R:Y174	7.255	4	0	7
30	R:R:P348	3.1825	4	0	9
31	R:R:Y356	4.948	5	0	9
32	R:R:V382	2.752	5	0	8
33	R:R:W390	7.57429	7	1	9
34	R:R:Y393	7.976	5	1	9
35	R:R:W416	6.6725	4	0	7
36	R:R:H418	6.545	4	0	4
37	R:R:N427	7.5175	4	0	9
38	R:R:N431	8.256	5	3	9
39	R:R:Y435	6.498	5	3	9
40	R:R:F442	5.746	5	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K7	L:L:L4	61.9077	1.41	No	Yes	0	0	0
2	L:L:K7	L:L:L63	59.0633	5.64	No	No	0	0	0
3	L:L:C23	L:L:K11	25.2047	6.47	No	Yes	5	0	0
4	L:L:K11	L:L:Y59	56.2055	17.91	Yes	No	0	0	0
5	L:L:L63	L:L:Y59	57.6391	5.86	No	No	0	0	0
6	L:L:C56	L:L:K11	25.2571	6.47	No	Yes	5	0	0
7	L:L:G13	L:L:L19	14.9454	5.13	No	No	0	0	0
8	L:L:L19	L:L:Y15	17.9267	1.17	No	No	0	0	0
9	L:L:V52	L:L:Y15	32.7928	16.4	Yes	No	0	0	0
10	L:L:C23	L:L:V52	23.7429	1.71	No	Yes	5	0	0
11	L:L:C56	L:L:V52	23.7953	1.71	No	Yes	5	0	0
12	L:L:G13	L:L:V12	11.9614	3.68	No	No	0	0	0
13	L:L:P16	L:L:Y15	11.9614	18.08	No	No	0	0	0
14	L:L:C49	L:L:V52	11.9614	3.42	No	Yes	0	0	0
15	R:R:F396	R:R:W416	10.9922	3.01	No	Yes	0	4	7
16	R:R:V419	R:R:W416	14.4635	3.68	No	Yes	0	5	7
17	R:R:L25	R:R:V419	15.0326	5.96	No	No	0	5	5
18	R:R:I29	R:R:L25	15.5991	5.71	No	No	0	7	5
19	R:R:A422	R:R:I29	16.1628	3.25	No	No	0	8	7
20	R:R:A422	R:R:L30	16.7239	3.15	No	No	0	8	6
21	R:R:L30	R:R:L75	17.2823	4.15	No	No	0	6	9
22	R:R:L75	R:R:S425	19.4891	9.01	No	No	0	9	8
23	R:R:C71	R:R:S425	20.0341	3.44	No	No	0	8	8
24	R:R:C71	R:R:M106	42.6991	3.24	No	Yes	0	8	9
25	R:R:I102	R:R:M106	100	4.37	No	Yes	0	8	9
26	L:L:L75	R:R:I102	99.7154	4.28	Yes	No	0	0	8
27	L:L:L75	R:R:I98	57.3129	8.56	Yes	Yes	2	0	8
28	R:R:I98	R:R:W88	56.7881	9.4	Yes	Yes	2	8	9
29	R:R:C95	R:R:W88	26.3658	9.14	Yes	Yes	2	9	9
30	R:R:C95	R:R:I163	49.4456	3.27	Yes	Yes	2	9	6
31	R:R:I163	R:R:N170	74.5094	5.66	Yes	No	0	6	4
32	R:R:N170	R:R:T166	73.1134	5.85	No	No	0	4	1
33	L:L:Q3	R:R:T166	68.9079	2.83	No	No	0	0	1
34	L:L:L75	R:R:P99	42.1058	9.85	Yes	No	2	0	8
35	R:R:P99	R:R:R161	41.8911	11.53	No	Yes	0	8	8
36	R:R:C95	R:R:R161	26.1349	4.18	Yes	Yes	0	9	8
37	R:R:C172	R:R:W88	25.3201	10.45	No	Yes	2	8	9
38	R:R:C172	R:R:I163	24.9416	8.18	No	Yes	2	8	6
39	R:R:C71	R:R:S428	31.8935	6.89	No	No	0	8	9
40	R:R:D68	R:R:S428	31.6693	7.36	Yes	No	0	9	9
41	R:R:D68	R:R:N41	23.7214	6.73	Yes	Yes	0	9	9
42	R:R:N41	R:R:P432	18.1253	6.52	Yes	No	0	9	9
43	R:R:P432	R:R:V44	17.6005	5.3	No	Yes	0	9	9
44	R:R:F442	R:R:V44	11.0674	5.24	Yes	Yes	4	9	9
45	R:R:D68	R:R:L64	18.5549	8.14	Yes	Yes	3	9	9
46	R:R:L64	R:R:Y435	32.0613	3.52	Yes	Yes	3	9	9
47	R:R:I116	R:R:Y435	34.6828	8.46	No	Yes	3	9	9
48	R:R:I116	R:R:W60	35.4761	3.52	No	Yes	0	9	8
49	R:R:D119	R:R:W60	23.9188	4.47	No	Yes	0	9	8
50	R:R:D119	R:R:R134	11.9721	8.34	No	Yes	6	9	9
51	R:R:M106	R:R:W390	64.536	9.31	Yes	Yes	1	9	9
52	R:R:N427	R:R:W390	47.5046	9.04	Yes	Yes	0	9	9
53	R:R:N427	R:R:N431	33.9418	9.54	Yes	Yes	0	9	9
54	R:R:L64	R:R:N431	14.3037	6.87	Yes	Yes	3	9	9
55	R:R:L113	R:R:N431	14.4272	10.98	No	Yes	3	8	9
56	R:R:L113	R:R:Y435	14.0366	10.55	No	Yes	3	8	9
57	R:R:F158	R:R:K96	12.148	11.17	No	No	0	8	8
58	R:R:F158	R:R:S100	10.4848	10.57	No	No	0	8	8
59	R:R:V110	R:R:W390	20.9348	7.36	No	Yes	0	9	9
60	R:R:F386	R:R:V110	17.2005	5.24	No	No	0	9	9
61	R:R:F386	R:R:N427	17.8448	3.62	No	Yes	0	9	9
62	R:R:F386	R:R:M352	32.3633	3.73	No	No	0	9	8
63	R:R:M352	R:R:Y356	13.4285	3.59	No	Yes	0	8	9
64	R:R:M352	R:R:S117	21.3697	6.13	No	No	0	8	9
65	R:R:C355	R:R:S117	20.469	5.16	No	No	0	9	9
66	R:R:D119	R:R:V123	10.7748	4.38	No	No	6	9	5
67	R:R:C121	R:R:C355	19.5656	7.28	No	No	0	9	9
68	R:R:C121	R:R:I359	10.3842	1.64	No	No	0	9	9
69	L:L:L4	L:L:Q3	64.6219	3.99	Yes	No	7	0	0
70	R:R:K96	R:R:R161	11.5775	3.71	No	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R65	R:R:P405	10.09	0	No	No	0	4	0	1
L:L:Q66	R:R:E162	3.82	9	No	No	0	5	0	1
L:L:Q66	R:R:F164	7.03	9	No	Yes	0	3	0	1
L:L:A70	R:R:F164	4.16	0	No	Yes	0	3	0	1
L:L:H72	R:R:Q85	17.31	0	No	No	0	5	0	1
L:L:H72	R:R:R171	19.18	0	No	Yes	0	1	0	1
L:L:G74	R:R:H418	3.18	0	No	Yes	0	4	0	1
L:L:L75	R:R:S78	6.01	2	Yes	No	0	8	0	1
L:L:L75	R:R:I98	8.56	2	Yes	Yes	0	8	0	1
L:L:L75	R:R:P99	9.85	2	Yes	No	0	8	0	1
L:L:L75	R:R:I102	4.28	2	Yes	No	0	8	0	1
L:L:A76	R:R:I421	6.5	0	No	No	0	4	0	1
L:L:R77	R:R:Y393	18.52	1	Yes	Yes	0	9	0	1
L:L:R77	R:R:G397	4.5	1	Yes	No	0	8	0	1
L:L:R77	R:R:D417	20.25	1	Yes	No	0	8	0	1
L:L:R77	R:R:I421	7.52	1	Yes	No	0	4	0	1
R:R:Q85	R:R:W18	5.48	0	No	No	5	1	1	2
R:R:H418	R:R:S26	4.18	0	Yes	No	4	8	1	2
R:R:I102	R:R:S74	7.74	0	No	No	8	9	1	2
R:R:F77	R:R:I98	15.07	0	No	Yes	8	8	2	1
R:R:G86	R:R:H81	7.94	2	No	No	7	7	2	2
R:R:H81	R:R:W88	3.17	2	No	Yes	7	9	2	2
R:R:H81	R:R:R171	21.44	2	No	Yes	7	1	2	1
R:R:H418	R:R:L82	15.43	0	Yes	No	4	7	1	2
R:R:G86	R:R:R171	9.01	2	No	Yes	7	1	2	1
R:R:I98	R:R:W88	9.4	2	Yes	Yes	8	9	1	2
R:R:I98	R:R:P99	8.47	2	Yes	No	8	8	1	1
R:R:P99	R:R:R161	11.53	2	No	Yes	8	8	1	2
R:R:I102	R:R:M106	4.37	0	No	Yes	8	9	1	2
R:R:M106	R:R:W390	9.31	1	Yes	Yes	9	9	2	2
R:R:M106	R:R:Y393	3.59	1	Yes	Yes	9	9	2	1
R:R:R161	R:R:Y174	17.49	0	Yes	Yes	8	7	2	2
R:R:E162	R:R:F164	15.16	9	No	Yes	5	3	1	1
R:R:E162	R:R:Y174	4.49	9	No	Yes	5	7	1	2
R:R:N170	R:R:T166	5.85	0	No	No	4	1	2	1
R:R:H418	R:R:R171	3.39	0	Yes	Yes	4	1	1	1
R:R:R340	R:R:Y393	4.12	1	No	Yes	9	9	2	1
R:R:W390	R:R:Y393	9.65	1	Yes	Yes	9	9	2	1
R:R:A424	R:R:W390	5.19	1	No	Yes	9	9	2	2
R:R:A424	R:R:Y393	4	1	No	Yes	9	9	2	1
R:R:D404	R:R:P405	11.27	0	No	No	4	4	2	1
R:R:D417	R:R:I421	4.2	1	No	No	8	4	1	1
R:R:F164	R:R:G173	3.01	9	Yes	No	3	1	1	2
L:L:Q3	R:R:T166	2.83	7	No	No	0	1	0	1
L:L:H67	R:R:F164	2.26	0	No	Yes	0	3	0	1
L:L:A68	R:R:P405	1.87	0	No	No	0	4	0	1
R:R:D167	R:R:T166	1.45	0	No	No	3	1	2	1
L:L:R69	R:R:L333	1.21	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8I9L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	319
Number of Links	343
Number of Hubs	40
Number of Links mediated by Hubs	150
Number of Communities	10
Number of Nodes involved in Communities	59
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	108168
Length Of Smallest Path	3
Average Path Length	20.0099
Length of Longest Path	43
Minimum Path Strength	1.515
Average Path Strength	6.23648
Maximum Path Strength	20.31
Minimum Path Correlation	0.7
Average Path Correlation	0.95186
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	48.2621
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.372
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • molecular function inhibitor activity • peptidase regulator activity • molecular function regulator activity • enzyme inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • C5L2 anaphylatoxin chemotactic receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • C5a anaphylatoxin chemotactic receptor binding • molecular function activator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • cellular response to stimulus • positive regulation of cell communication • regulation of biological process • regulation of signaling • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • biological regulation • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • cell communication • positive regulation of response to stimulus • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of biological process • regulation of signaling • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • biological regulation • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • cell communication • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of signaling • neutral lipid metabolic process • neutral lipid biosynthetic process • regulation of triglyceride metabolic process • regulation of lipid metabolic process • lipid biosynthetic process • regulation of primary metabolic process • acylglycerol biosynthetic process • triglyceride metabolic process • triglyceride biosynthetic process • regulation of biosynthetic process • regulation of triglyceride biosynthetic process • primary metabolic process • biosynthetic process • glycerolipid biosynthetic process • metabolic process • glycerolipid metabolic process • regulation of lipid biosynthetic process • acylglycerol metabolic process • regulation of metabolic process • lipid metabolic process • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • lymphocyte mediated immunity • humoral immune response • complement activation • humoral immune response mediated by circulating immunoglobulin • positive regulation of immune response • leukocyte mediated immunity • regulation of immune system process • positive regulation of immune system process • complement activation, classical pathway • immune response • immunoglobulin mediated immune response • adaptive immune response • immune effector process • immune system process • B cell mediated immunity • regulation of immune response • activation of immune response • developmental process • multicellular organismal process • cellular developmental process • cell development • developmental maturation • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • neuron remodeling • anatomical structure maturation • cell differentiation • neuron development • anatomical structure development • neuron maturation • cell maturation • system development • B cell activation • cell activation • lymphocyte activation • leukocyte activation • regulation of humoral immune response • regulation of immune effector process • positive regulation of humoral immune response • positive regulation of complement activation • positive regulation of immune effector process • activation of membrane attack complex • positive regulation of activation of membrane attack complex • regulation of activation of membrane attack complex • regulation of complement activation • visual system development • pattern specification process • regionalization • central nervous system development • sensory system development • vertebrate eye-specific patterning • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • cellular component organization or biogenesis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of transport • endocytosis • receptor-mediated endocytosis • biological process involved in interspecies interaction between organisms • complement activation, alternative pathway • response to biotic stimulus • response to stress • innate immune response • response to external biotic stimulus • response to other organism • defense response • defense response to symbiont • response to external stimulus • defense response to other organism • epithelium development • oviduct development • reproductive system development • oviduct epithelium development • tube development • reproductive process • developmental process involved in reproduction • tissue development • reproductive structure development • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • positive regulation of membrane invagination • regulation of phagocytosis, engulfment • membrane invagination • phagocytosis • plasma membrane invagination • membrane organization • regulation of phagocytosis • phagocytosis, engulfment • positive regulation of phagocytosis • positive regulation of phagocytosis, engulfment • regulation of membrane invagination • cellular component disassembly • complement-mediated synapse pruning • cell junction organization • cell junction disassembly • synapse pruning • synapse organization • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • amyloid-beta clearance • lipid storage • lipid localization • positive regulation of lipid localization • regulation of lipid storage • regulation of lipid localization • macromolecule localization • nutrient storage • positive regulation of lipid storage • fatty acid metabolic process • oxoacid metabolic process • carboxylic acid metabolic process • small molecule metabolic process • monocarboxylic acid metabolic process • organic acid metabolic process • positive regulation of acute inflammatory response to antigenic stimulus • regulation of myeloid leukocyte mediated immunity • regulation of acute inflammatory response to antigenic stimulus • positive regulation of leukocyte mediated immunity • regulation of type IIa hypersensitivity • myeloid leukocyte mediated immunity • inflammatory response to antigenic stimulus • positive regulation of hypersensitivity • positive regulation of inflammatory response • positive regulation of adaptive immune response • regulation of type II hypersensitivity • positive regulation of immunoglobulin mediated immune response • hypersensitivity • regulation of adaptive immune response • regulation of inflammatory response • regulation of B cell mediated immunity • regulation of leukocyte mediated immunity • type II hypersensitivity • positive regulation of myeloid leukocyte mediated immunity • type IIa hypersensitivity • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • regulation of defense response • regulation of response to external stimulus • positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of lymphocyte mediated immunity • positive regulation of acute inflammatory response • positive regulation of B cell mediated immunity • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of response to external stimulus • regulation of immunoglobulin mediated immune response • regulation of response to stress • acute inflammatory response • regulation of hypersensitivity • regulation of inflammatory response to antigenic stimulus • acute inflammatory response to antigenic stimulus • positive regulation of inflammatory response to antigenic stimulus • positive regulation of type IIa hypersensitivity • regulation of lymphocyte mediated immunity • positive regulation of type II hypersensitivity • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • response to bacterium • complement-dependent cytotoxicity • cell killing • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • positive regulation of apoptotic cell clearance • apoptotic cell clearance • regulation of apoptotic cell clearance • hexose transmembrane transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • transmembrane transport • regulation of transmembrane transport • D-glucose transmembrane transport • positive regulation of transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • extracellular exosome • membrane-bounded organelle • extracellular vesicle • cellular anatomical structure • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• extracellular exosome • membrane-bounded organelle • extracellular vesicle • cellular anatomical structure • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • intracellular organelle • organelle lumen • endoplasmic reticulum • cytoplasm • cell surface • cell periphery • plasma membrane • membrane • lytic vacuole • intracellular vesicle • cytoplasmic vesicle lumen • vacuolar lumen • cytoplasmic vesicle • lysosome • vesicle lumen • azurophil granule • vacuole • secretory granule lumen • azurophil granule lumen • secretory granule • primary lysosome • secretory vesicle • protein-containing complex • blood microparticle • complement component C3a receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • G protein-coupled receptor activity • cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • response to stimulus • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of biological process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • response to chemical • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • biological regulation • positive regulation of leukocyte migration • regulation of chemotaxis • cellular response to chemical stimulus • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular process • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • system process • circulatory system process • blood circulation • specific granule membrane • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • organelle membrane • secretory granule membrane • specific granule • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • azurophil granule membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • synapse • cell junction • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • regulation of blood circulation • heart contraction • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8I9L_nogp_Chain_R W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I9L_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.