Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L30 6.03566
2R:R:T33 4.0525408
3R:R:N41 4.5075409
4R:R:V44 4.3775449
5R:R:V47 5.6525448
6R:R:I59 3.602506
7R:R:W60 5.00333608
8R:R:H63 7.535408
9R:R:L64 5.88833619
10R:R:D68 6.996519
11R:R:L75 6.45569
12R:R:W88 6.3275409
13R:R:I98 8.574108
14R:R:F107 5.2975458
15R:R:L113 8.1125418
16R:R:T114 3.55254128
17R:R:I116 5.815419
18R:R:S117 3.3825409
19R:R:V123 4.41435
20R:R:W129 7.2025436
21R:R:C130 4.565437
22R:R:R134 7.6475439
23R:R:W147 4.69409
24R:R:R161 6.55754118
25R:R:I336 4.265407
26R:R:T337 4.0954147
27R:R:R340 5.7075459
28R:R:P348 4.005409
29R:R:Y356 4.395619
30R:R:R362 5.725407
31R:R:V382 2.3775418
32R:R:F386 5.286529
33R:R:L387 3.3125426
34R:R:W390 6.09429729
35R:R:T391 4.6425426
36R:R:Y393 4.6925429
37R:R:L413 6.36507
38R:R:W416 5.868577
39R:R:N431 9.5575419
40R:R:Y435 6.10667619
41R:R:F442 6.07549
42R:R:K445 6.115447
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:A422 R:R:S26 10.41971.71NoNo088
2R:R:A422 R:R:L30 13.77323.15NoYes086
3R:R:L30 R:R:L75 24.002411.07YesYes669
4R:R:L30 R:R:S425 42.1583YesNo068
5R:R:L75 R:R:T33 13.36492.95YesYes098
6R:R:F34 R:R:L75 10.087610.96NoYes079
7R:R:C71 R:R:S425 43.34483.44NoNo088
8R:R:C71 R:R:S428 47.01946.89NoNo089
9R:R:D68 R:R:S428 48.30427.36YesNo099
10R:R:D68 R:R:N41 44.72214.04YesYes099
11R:R:N41 R:R:P432 39.08216.52YesNo099
12R:R:P432 R:R:V44 37.64491.77NoYes099
13R:R:F442 R:R:V44 30.18139.18YesYes499
14R:R:F442 R:R:V47 16.489711.8YesYes498
15R:R:D68 R:R:L64 39.90428.14YesYes199
16R:R:L112 R:R:L64 25.92964.15NoYes099
17R:R:H63 R:R:L112 22.04263.86YesNo089
18R:R:H63 R:R:I59 12.50482.65YesYes086
19R:R:L64 R:R:Y435 47.93953.52YesYes199
20R:R:I116 R:R:Y435 78.94288.46YesYes199
21R:R:I116 R:R:W60 82.29083.52YesYes098
22R:R:D119 R:R:W60 76.09568.93NoYes098
23R:R:D119 R:R:R134 27.775110.72NoYes399
24R:R:L113 R:R:L64 12.97295.54YesYes189
25R:R:D68 R:R:N431 42.91478.08YesYes199
26R:R:L113 R:R:N431 31.308212.36YesYes189
27R:R:F396 R:R:W416 16.69665.01NoYes047
28R:R:C420 R:R:F396 31.15034.19NoNo064
29R:R:C420 R:R:Y393 32.60384.03NoYes069
30R:R:W390 R:R:Y393 37.07334.82YesYes299
31R:R:M106 R:R:W390 1008.14NoYes099
32R:R:F107 R:R:M106 98.67712.49YesNo089
33R:R:F107 R:R:R340 85.7268.55YesYes589
34R:R:R340 R:R:V157 68.49582.62YesNo099
35R:R:S100 R:R:V157 39.03863.23NoNo089
36R:R:F158 R:R:S100 37.28022.64NoNo088
37R:R:F158 R:R:K96 35.510916.13NoNo088
38R:R:K96 R:R:R161 30.137713.61NoYes088
39R:R:C95 R:R:R161 13.32145.57NoYes1198
40R:R:C95 R:R:P99 11.58471.88NoNo098
41R:R:N427 R:R:N431 89.46056.81NoYes099
42R:R:N427 R:R:W390 88.17037.91NoYes099
43R:R:H81 R:R:W88 13.59362.12NoYes079
44R:R:G86 R:R:H81 15.49896.35NoNo077
45R:R:G86 R:R:Q87 17.3886.58NoNo076
46R:R:Q87 R:R:R171 24.83538.18NoNo061
47R:R:G173 R:R:R171 26.66993NoNo011
48R:R:G173 R:R:Y174 28.49371.45NoNo017
49R:R:V157 R:R:Y174 31.93971.26NoNo097
50R:R:F107 R:R:M153 11.68826.22YesNo588
51R:R:F386 R:R:W390 38.42895.01YesYes299
52R:R:L113 R:R:M352 45.13042.83YesNo088
53R:R:F386 R:R:M352 42.337611.2YesNo098
54R:R:M352 R:R:S117 26.92583.07NoYes089
55R:R:Y356 R:R:Y435 17.00692.98YesYes199
56R:R:S117 R:R:Y356 25.34713.82YesYes099
57R:R:C355 R:R:S117 32.1033.44NoYes099
58R:R:D119 R:R:V123 46.30634.38NoYes395
59R:R:C355 R:R:I359 27.18713.27NoNo1399
60R:R:C130 R:R:V123 23.83915.12YesYes375
61R:R:C130 R:R:L122 14.18696.35YesNo377
62R:R:C130 R:R:R134 23.40364.18YesYes379
63R:R:C130 R:R:W129 28.37932.61YesYes376
64R:R:V123 R:R:V124 21.29131.6YesNo059
65R:R:R362 R:R:V124 18.92322.62YesNo079
66R:R:H133 R:R:W129 14.252315.87NoYes086
67R:R:I336 R:R:R340 20.97562.51YesYes079
68R:R:H394 R:R:W390 10.2024.23NoYes099
69R:R:F386 R:R:L387 11.24723.65YesYes296
70R:R:I359 R:R:M363 24.80272.92NoNo097
71R:R:M363 R:R:Q372 19.98485.44NoNo075
72R:R:Q372 R:R:V360 10.14214.3NoNo056
73R:R:F396 R:R:L413 16.8984.87NoYes047
74R:R:L64 R:R:N431 33.779710.98YesYes199
75R:R:L113 R:R:Y435 44.656811.72YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8I97_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.49
Number of Linked Nodes 257
Number of Links 289
Number of Hubs 42
Number of Links mediated by Hubs 153
Number of Communities 14
Number of Nodes involved in Communities 66
Number of Links involved in Communities 81
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 47519
Length Of Smallest Path 3
Average Path Length 13.6447
Length of Longest Path 27
Minimum Path Strength 1.19
Average Path Strength 5.62793
Maximum Path Strength 16.13
Minimum Path Correlation 0.7
Average Path Correlation 0.922875
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 49.1849
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.38
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8I97_nogp_Chain_R
NEPPVILSM VILSLTFLL GLPGNGLVL WVAGLKMQR TVNTIWFLH 
LTLADLLCC LSLPFSLAH LALQGQWPY GRFLCKLIP SIIVLNMFA 
SVFLLTAIS LDRCLVVFK PIWCQNHRN VGMACSICG CIWVVAFVM 
CIPVFVYRE IFTTDNHNR CGYTPLVAI TITRLVVGF LLPSVIMIA 
CYSFIVFRM QRGRFAKSQ SKTFRVAVV VVAVFLVCW TPYHIFGVL 
SLLTDPETP LGKTLMSWD HVCIALASA NSCFNPFLY ALLGKDFRK 
KARQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KVP (No Gprot) APeptideComplement PeptideC3aBHomo sapiensSB290157-2.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP67-3.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZ8 (No Gprot) APeptideComplement PeptideC3aBMus musculusEP67-3.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9KZK (No Gprot) APeptideComplement PeptideC3aBMus musculusC3a (fragment)-3.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9L0H (No Gprot) APeptideComplement PeptideC3aBMus musculusJR14a-3.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9UMJ (No Gprot) APeptideComplement PeptideC3aBMus musculusEP54-3.382025-11-2610.1101/2025.05.26.656101
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWF (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KUT (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-3.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV6 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-2.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KV8 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-3.172025-11-2610.1101/2025.05.26.656101




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I97_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.