psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E20	R:R:P21	6.29	No	No	5	4	6
2	R:R:E20	R:R:P22	4.72	No	Yes	5	4	4
3	R:R:P21	R:R:P22	7.79	No	Yes	5	6	4
4	R:R:P22	R:R:S415	7.13	Yes	No	5	4	5
5	R:R:P22	R:R:W416	9.46	Yes	Yes	5	4	7
6	R:R:M27	R:R:V23	6.09	No	No	0	6	4
7	R:R:I29	R:R:L25	2.85	No	No	0	7	5
8	R:R:L82	R:R:S26	4.5	No	No	2	7	8
9	R:R:H418	R:R:S26	2.79	No	No	2	4	8
10	R:R:A422	R:R:I29	4.87	No	No	0	8	7
11	R:R:L30	R:R:L75	8.3	Yes	Yes	2	6	9
12	R:R:L30	R:R:S78	6.01	Yes	No	2	6	8
13	R:R:L30	R:R:L79	6.92	Yes	No	2	6	6
14	R:R:L30	R:R:L82	2.77	Yes	No	2	6	7
15	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
16	R:R:L30	R:R:S425	3	Yes	No	2	6	8
17	R:R:L75	R:R:T33	2.95	Yes	Yes	2	9	8
18	R:R:S425	R:R:T33	6.4	No	Yes	2	8	8
19	R:R:A426	R:R:T33	5.03	No	Yes	0	8	8
20	R:R:C429	R:R:T33	6.76	No	Yes	2	9	8
21	R:R:F34	R:R:L38	8.53	No	Yes	0	7	7
22	R:R:F34	R:R:L75	2.44	No	Yes	0	7	9
23	R:R:C429	R:R:L36	3.17	No	No	2	9	8
24	R:R:F430	R:R:L36	2.44	No	No	2	7	8
25	R:R:F433	R:R:L36	6.09	No	No	0	6	8
26	R:R:G37	R:R:N41	3.39	No	Yes	0	9	9
27	R:R:L38	R:R:P39	3.28	Yes	No	0	7	7
28	R:R:D68	R:R:N41	4.04	Yes	Yes	0	9	9
29	R:R:C72	R:R:N41	4.72	No	Yes	0	8	9
30	R:R:N41	R:R:P432	6.52	Yes	No	0	9	9
31	R:R:T65	R:R:V44	3.17	No	No	0	9	9
32	R:R:A436	R:R:V44	3.39	No	No	0	8	9
33	R:R:F442	R:R:V44	7.87	Yes	No	0	9	9
34	R:R:L50	R:R:W46	6.83	No	No	0	4	6
35	R:R:S449	R:R:W46	7.41	No	No	0	9	6
36	R:R:K51	R:R:V47	3.04	No	Yes	6	9	8
37	R:R:F442	R:R:V47	6.55	Yes	Yes	0	9	8
38	R:R:K445	R:R:V47	3.04	No	Yes	6	7	8
39	R:R:S449	R:R:V47	3.23	No	Yes	6	9	8
40	R:R:A48	R:R:F442	2.77	No	Yes	0	7	9
41	R:R:K445	R:R:K51	5.75	No	No	6	7	9
42	R:R:K51	R:R:S449	4.59	No	No	6	9	9
43	R:R:M52	R:R:T58	4.52	No	Yes	0	9	8
44	R:R:D441	R:R:M52	2.77	No	No	0	7	9
45	R:R:R54	R:R:T58	7.76	No	Yes	0	7	8
46	R:R:L62	R:R:R54	4.86	No	No	0	8	7
47	R:R:N57	R:R:T55	8.77	No	No	8	8	9
48	R:R:T55	R:R:T58	3.14	No	Yes	8	9	8
49	R:R:R134	R:R:V56	6.54	Yes	No	0	9	8
50	R:R:N57	R:R:T58	2.92	No	Yes	8	8	8
51	R:R:H63	R:R:I59	2.65	Yes	Yes	0	8	6
52	R:R:I59	R:R:V136	3.07	Yes	No	0	6	7
53	R:R:A139	R:R:I59	3.25	No	Yes	0	7	6
54	R:R:A115	R:R:W60	2.59	No	Yes	0	7	8
55	R:R:I116	R:R:W60	3.52	Yes	Yes	0	9	8
56	R:R:D119	R:R:W60	5.58	No	Yes	0	9	8
57	R:R:A139	R:R:W60	5.19	No	Yes	0	7	8
58	R:R:I142	R:R:W60	5.87	No	Yes	0	5	8
59	R:R:C143	R:R:W60	2.61	No	Yes	0	8	8
60	R:R:F61	R:R:I116	2.51	No	Yes	1	8	9
61	R:R:F61	R:R:Y435	3.09	No	Yes	1	8	9
62	R:R:H63	R:R:L112	2.57	Yes	No	0	8	9
63	R:R:C143	R:R:H63	16.22	No	Yes	0	8	8
64	R:R:H63	R:R:W147	7.41	Yes	No	0	8	9
65	R:R:D68	R:R:L64	8.14	Yes	Yes	1	9	9
66	R:R:L64	R:R:S109	3	Yes	No	1	9	9
67	R:R:L113	R:R:L64	5.54	Yes	Yes	1	8	9
68	R:R:L64	R:R:N431	4.12	Yes	Yes	1	9	9
69	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
70	R:R:L66	R:R:W147	3.42	No	No	0	4	9
71	R:R:A67	R:R:N105	4.69	No	No	0	9	9
72	R:R:D68	R:R:S109	5.89	Yes	No	1	9	9
73	R:R:D68	R:R:S428	7.36	Yes	No	0	9	9
74	R:R:D68	R:R:N431	8.08	Yes	Yes	1	9	9
75	R:R:L69	R:R:L73	2.77	No	No	7	7	8
76	R:R:L70	R:R:N105	4.12	No	No	0	6	9
77	R:R:C71	R:R:N105	6.3	No	No	0	8	9
78	R:R:C71	R:R:S428	6.89	No	No	0	8	9
79	R:R:I102	R:R:S74	7.74	Yes	No	0	8	9
80	R:R:L75	R:R:P76	3.28	Yes	No	0	9	9
81	R:R:L75	R:R:S78	4.5	Yes	No	2	9	8
82	R:R:L75	R:R:L79	2.77	Yes	No	2	9	6
83	R:R:L75	R:R:S425	3	Yes	No	2	9	8
84	R:R:F77	R:R:I98	17.58	No	No	0	8	8
85	R:R:A80	R:R:W88	2.59	No	Yes	0	5	9
86	R:R:G86	R:R:H81	7.94	No	No	0	7	7
87	R:R:H81	R:R:W88	20.1	No	Yes	0	7	9
88	R:R:H418	R:R:L82	6.43	No	No	2	4	7
89	R:R:L84	R:R:P89	3.28	No	No	0	8	8
90	R:R:Q85	R:R:Q87	8.96	No	Yes	9	5	6
91	R:R:Q85	R:R:R171	4.67	No	No	9	5	1
92	R:R:G86	R:R:Q87	6.58	No	Yes	0	7	6
93	R:R:H169	R:R:Q87	6.18	No	Yes	0	3	6
94	R:R:Q87	R:R:R171	16.35	Yes	No	9	6	1
95	R:R:P89	R:R:W88	2.7	No	Yes	0	8	9
96	R:R:C95	R:R:W88	5.22	Yes	Yes	3	9	9
97	R:R:C172	R:R:W88	2.61	Yes	Yes	3	8	9
98	R:R:L94	R:R:Y90	9.38	No	No	0	8	7
99	R:R:K96	R:R:R92	3.71	No	No	3	8	1
100	R:R:R161	R:R:R92	10.66	Yes	No	3	8	1
101	R:R:I163	R:R:R92	6.26	Yes	No	3	6	1
102	R:R:F93	R:R:L97	2.44	No	No	0	4	6
103	R:R:C95	R:R:P99	3.77	Yes	No	0	9	8
104	R:R:C95	R:R:R161	5.57	Yes	Yes	3	9	8
105	R:R:C172	R:R:C95	7.28	Yes	Yes	3	8	9
106	R:R:F158	R:R:K96	12.41	No	No	0	8	8
107	R:R:K96	R:R:R161	12.38	No	Yes	3	8	8
108	R:R:I98	R:R:P99	8.47	No	No	0	8	8
109	R:R:I102	R:R:I98	4.42	Yes	No	0	8	8
110	R:R:S100	R:R:V157	3.23	No	No	0	8	9
111	R:R:F158	R:R:S100	2.64	No	No	0	8	8
112	R:R:I102	R:R:M106	4.37	Yes	No	0	8	9
113	R:R:F107	R:R:V103	7.87	No	No	0	8	5
114	R:R:C154	R:R:V103	3.42	No	No	0	8	5
115	R:R:F151	R:R:L104	3.65	No	No	0	5	8
116	R:R:M106	R:R:W390	5.82	No	Yes	0	9	9
117	R:R:F107	R:R:R340	11.76	No	No	0	8	9
118	R:R:A108	R:R:W147	3.89	No	No	0	9	9
119	R:R:P348	R:R:V110	3.53	No	No	0	9	9
120	R:R:F386	R:R:V110	2.62	Yes	No	1	9	9
121	R:R:V110	R:R:W390	3.68	No	Yes	1	9	9
122	R:R:F111	R:R:I146	2.51	No	No	0	8	8
123	R:R:I146	R:R:L112	5.71	No	No	0	8	9
124	R:R:F386	R:R:L113	2.44	Yes	Yes	1	9	8
125	R:R:L113	R:R:N431	8.24	Yes	Yes	1	8	9
126	R:R:L113	R:R:Y435	9.38	Yes	Yes	1	8	9
127	R:R:S117	R:R:T114	3.2	No	Yes	0	9	8
128	R:R:L118	R:R:T114	2.95	No	Yes	10	8	8
129	R:R:P348	R:R:T114	3.5	No	Yes	0	9	8
130	R:R:I351	R:R:T114	4.56	No	Yes	10	6	8
131	R:R:I116	R:R:R120	5.01	Yes	No	0	9	9
132	R:R:I116	R:R:Y435	6.04	Yes	Yes	1	9	9
133	R:R:M352	R:R:S117	6.13	No	No	0	8	9
134	R:R:I351	R:R:L118	2.85	No	No	10	6	8
135	R:R:D119	R:R:V123	4.38	No	No	4	9	5
136	R:R:D119	R:R:R134	9.53	No	Yes	4	9	9
137	R:R:R120	R:R:Y356	8.23	No	Yes	0	9	9
138	R:R:C121	R:R:C355	7.28	No	No	11	9	9
139	R:R:C121	R:R:I359	4.91	No	No	11	9	9
140	R:R:L122	R:R:W129	7.97	No	Yes	4	7	6
141	R:R:C130	R:R:L122	6.35	No	No	4	7	7
142	R:R:R134	R:R:V123	6.54	Yes	No	4	9	5
143	R:R:F125	R:R:V124	2.62	No	No	0	6	9
144	R:R:F125	R:R:F358	8.57	No	No	0	6	6
145	R:R:F125	R:R:R362	3.21	No	No	0	6	7
146	R:R:C130	R:R:W129	2.61	No	Yes	4	7	6
147	R:R:H133	R:R:W129	13.75	No	Yes	0	8	6
148	R:R:C130	R:R:R134	2.79	No	Yes	4	7	9
149	R:R:H133	R:R:N132	6.38	No	No	0	8	8
150	R:R:G137	R:R:N135	3.39	No	No	0	5	5
151	R:R:M138	R:R:N135	2.8	No	No	0	6	5
152	R:R:I142	R:R:I146	2.94	No	No	0	5	8
153	R:R:M153	R:R:V149	4.56	No	No	0	8	4
154	R:R:F151	R:R:I155	2.51	No	No	0	5	5
155	R:R:M153	R:R:V152	4.56	No	No	0	8	5
156	R:R:I155	R:R:P156	3.39	No	No	0	5	9
157	R:R:I155	R:R:V159	3.07	No	No	0	5	4
158	R:R:I336	R:R:P156	3.39	No	No	0	7	9
159	R:R:V157	R:R:Y174	3.79	No	No	0	9	7
160	R:R:V159	R:R:Y160	3.79	No	No	0	4	8
161	R:R:I163	R:R:R161	10.02	Yes	Yes	3	6	8
162	R:R:C172	R:R:R161	4.18	Yes	Yes	3	8	8
163	R:R:I163	R:R:N170	5.66	Yes	No	0	6	4
164	R:R:C172	R:R:I163	3.27	Yes	Yes	3	8	6
165	R:R:F164	R:R:T166	9.08	No	No	0	3	1
166	R:R:N170	R:R:T165	7.31	No	No	0	4	4
167	R:R:D167	R:R:N168	9.42	No	No	0	3	5
168	R:R:H169	R:R:N168	2.55	No	No	0	3	5
169	R:R:P332	R:R:T331	3.5	No	No	0	4	4
170	R:R:L333	R:R:T337	2.95	No	No	0	3	7
171	R:R:L401	R:R:V334	2.98	No	No	0	7	4
172	R:R:I336	R:R:R340	2.51	No	No	0	7	9
173	R:R:T339	R:R:V343	3.17	No	No	0	8	4
174	R:R:R340	R:R:Y393	8.23	No	Yes	0	9	9
175	R:R:H394	R:R:L341	2.57	No	No	0	9	6
176	R:R:G344	R:R:P348	4.06	No	No	0	9	9
177	R:R:F345	R:R:L387	2.44	No	Yes	1	9	6
178	R:R:F345	R:R:T391	10.38	No	Yes	1	9	6
179	R:R:F345	R:R:H394	7.92	No	No	0	9	9
180	R:R:I351	R:R:L347	2.85	No	No	0	6	7
181	R:R:M352	R:R:Y356	4.79	No	Yes	0	8	9
182	R:R:I353	R:R:V383	4.61	No	No	0	5	8
183	R:R:C355	R:R:I359	3.27	No	No	11	9	9
184	R:R:A379	R:R:Y356	6.67	No	Yes	0	7	9
185	R:R:V382	R:R:Y356	2.52	Yes	Yes	0	8	9
186	R:R:Q372	R:R:V360	2.87	No	No	0	5	6
187	R:R:F376	R:R:V360	3.93	No	No	0	4	6
188	R:R:R362	R:R:R365	8.53	No	No	0	7	4
189	R:R:F368	R:R:M363	13.68	No	No	0	5	7
190	R:R:M363	R:R:S371	3.07	No	No	0	7	7
191	R:R:M363	R:R:Q372	2.72	No	No	0	7	5
192	R:R:Q364	R:R:Q372	7.68	No	No	0	5	5
193	R:R:F368	R:R:R367	3.21	No	No	0	5	6
194	R:R:L438	R:R:V378	4.47	No	No	0	7	8
195	R:R:V382	R:R:Y435	5.05	Yes	Yes	0	8	9
196	R:R:L434	R:R:V385	4.47	No	No	0	9	7
197	R:R:F386	R:R:L387	3.65	Yes	Yes	1	9	6
198	R:R:F386	R:R:W390	4.01	Yes	Yes	1	9	9
199	R:R:L387	R:R:T391	2.95	Yes	Yes	1	6	6
200	R:R:C389	R:R:N427	11.02	No	No	0	9	9
201	R:R:W390	R:R:Y393	3.86	Yes	Yes	0	9	9
202	R:R:H394	R:R:W390	6.35	No	Yes	0	9	9
203	R:R:A424	R:R:W390	5.19	No	Yes	0	9	9
204	R:R:N427	R:R:W390	7.91	No	Yes	0	9	9
205	R:R:P392	R:R:T391	3.5	No	Yes	0	9	6
206	R:R:I395	R:R:T391	4.56	No	Yes	0	5	6
207	R:R:I421	R:R:Y393	6.04	No	Yes	0	4	9
208	R:R:F396	R:R:I395	3.77	Yes	No	0	4	5
209	R:R:F396	R:R:L399	2.44	Yes	No	0	4	9
210	R:R:F396	R:R:W416	3.01	Yes	Yes	0	4	7
211	R:R:C420	R:R:F396	5.59	No	Yes	0	6	4
212	R:R:L399	R:R:L413	9.69	No	Yes	0	9	7
213	R:R:L413	R:R:S400	6.01	Yes	No	0	7	2
214	R:R:L409	R:R:T403	4.42	No	No	0	3	2
215	R:R:L413	R:R:T403	5.9	Yes	No	0	7	2
216	R:R:D404	R:R:P405	4.83	No	No	0	4	4
217	R:R:E406	R:R:K411	4.05	No	No	0	1	2
218	R:R:P408	R:R:T407	3.5	No	No	0	4	7
219	R:R:G410	R:R:L413	6.84	No	Yes	0	3	7
220	R:R:K411	R:R:M414	2.88	No	No	0	2	2
221	R:R:S415	R:R:W416	7.41	No	Yes	5	5	7
222	R:R:V419	R:R:W416	3.68	No	Yes	0	5	7
223	R:R:N427	R:R:N431	8.17	No	Yes	0	9	9
224	R:R:C429	R:R:F430	4.19	No	No	2	9	7
225	R:R:K440	R:R:R443	11.14	No	No	0	7	9
226	R:R:D441	R:R:F442	3.58	No	Yes	0	7	9
227	R:R:K444	R:R:R443	2.48	No	No	0	5	9
228	R:R:K445	R:R:Q448	2.71	No	No	0	7	7
229	R:R:T412	R:R:W416	2.43	No	Yes	0	6	7
230	R:R:I359	R:R:Y356	2.42	No	Yes	0	9	9
231	R:R:D417	R:R:Y393	2.3	No	Yes	0	8	9
232	R:R:F368	R:R:R362	2.14	No	No	0	5	7
233	R:R:G37	R:R:P39	2.03	No	No	0	9	7
234	R:R:G40	R:R:P39	2.03	No	No	0	9	7
235	R:R:C140	R:R:G137	1.96	No	No	0	4	5
236	R:R:A108	R:R:A150	1.79	No	No	0	9	9
237	R:R:G91	R:R:L94	1.71	No	No	0	9	8
238	R:R:C389	R:R:V385	1.71	No	No	0	9	7
239	R:R:C389	R:R:V388	1.71	No	No	0	9	6
240	R:R:G42	R:R:N41	1.7	No	Yes	0	6	9
241	R:R:A446	R:R:V47	1.7	No	Yes	0	8	8
242	R:R:D441	R:R:G439	1.68	No	No	0	7	9
243	R:R:K126	R:R:P127	1.67	No	No	0	6	9
244	R:R:K411	R:R:P408	1.67	No	No	0	2	4
245	R:R:S349	R:R:V350	1.62	No	No	0	4	4
246	R:R:V123	R:R:V124	1.6	No	No	0	5	9
247	R:R:V148	R:R:V152	1.6	No	No	0	5	5
248	R:R:V342	R:R:V343	1.6	No	No	0	6	4
249	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
250	R:R:V381	R:R:V382	1.6	No	Yes	0	7	8
251	R:R:T337	R:R:V398	1.59	No	No	0	7	7
252	R:R:T375	R:R:V360	1.59	No	No	0	7	6
253	R:R:A436	R:R:L437	1.58	No	No	0	8	7
254	R:R:I338	R:R:V334	1.54	No	No	0	6	4
255	R:R:I338	R:R:V342	1.54	No	No	0	6	6
256	R:R:I59	R:R:T58	1.52	Yes	Yes	0	6	8
257	R:R:I336	R:R:T337	1.52	No	No	0	7	7
258	R:R:L387	R:R:S349	1.5	Yes	No	0	6	4
259	R:R:G366	R:R:R367	1.5	No	No	0	2	6
260	R:R:K374	R:R:T375	1.5	No	No	0	9	7
261	R:R:L32	R:R:V28	1.49	No	No	0	6	6
262	R:R:L387	R:R:V383	1.49	Yes	No	0	6	8
263	R:R:L32	R:R:T33	1.47	No	Yes	0	6	8
264	R:R:L45	R:R:T65	1.47	No	No	0	8	9
265	R:R:I101	R:R:I102	1.47	No	Yes	0	5	8
266	R:R:L409	R:R:T407	1.47	No	No	0	3	7
267	R:R:I24	R:R:M27	1.46	No	No	0	7	6
268	R:R:D167	R:R:T166	1.45	No	No	0	3	1
269	R:R:G173	R:R:Y174	1.45	No	No	0	1	7
270	R:R:E20	R:R:V23	1.43	No	No	0	4	4
271	R:R:I450	R:R:L43	1.43	No	No	0	4	8
272	R:R:P89	R:R:Y90	1.39	No	No	0	8	7
273	R:R:L38	R:R:L69	1.38	Yes	No	7	7	7
274	R:R:L38	R:R:L73	1.38	Yes	No	7	7	8
275	R:R:L45	R:R:L69	1.38	No	No	0	8	7
276	R:R:L341	R:R:L346	1.38	No	No	0	6	8
277	R:R:L399	R:R:L402	1.38	No	No	0	9	5
278	R:R:M52	R:R:Q53	1.36	No	No	0	9	6
279	R:R:F111	R:R:V343	1.31	No	No	0	8	4
280	R:R:R377	R:R:V380	1.31	No	No	0	5	3
281	R:R:F93	R:R:L94	1.22	No	No	0	4	8
282	R:R:K126	R:R:W129	1.16	No	Yes	0	6	6
283	R:R:M138	R:R:W129	1.16	No	Yes	0	6	6
284	R:R:L43	R:R:W46	1.14	No	No	0	8	6
285	R:R:E162	R:R:Y174	1.12	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P22	7.275	4	5	4
2	R:R:L30	5.025	6	2	6
3	R:R:T33	4.522	5	2	8
4	R:R:L38	3.6425	4	7	7
5	R:R:N41	4.074	5	0	9
6	R:R:V47	3.512	5	6	8
7	R:R:T58	3.972	5	8	8
8	R:R:I59	2.6225	4	0	6
9	R:R:W60	4.22667	6	0	8
10	R:R:H63	7.2125	4	0	8
11	R:R:L64	4.864	5	1	9
12	R:R:D68	6.702	5	1	9
13	R:R:L75	3.89143	7	2	9
14	R:R:Q87	9.5175	4	9	6
15	R:R:W88	6.644	5	3	9
16	R:R:C95	5.46	4	3	9
17	R:R:I102	4.5	4	0	8
18	R:R:L113	6.4	4	1	8
19	R:R:T114	3.5525	4	10	8
20	R:R:I116	4.27	4	1	9
21	R:R:W129	5.33	5	4	6
22	R:R:R134	6.35	4	4	9
23	R:R:R161	8.562	5	3	8
24	R:R:I163	6.3025	4	3	6
25	R:R:C172	4.335	4	3	8
26	R:R:Y356	4.926	5	0	9
27	R:R:V382	2.6925	4	0	8
28	R:R:F386	3.18	4	1	9
29	R:R:L387	2.406	5	1	6
30	R:R:W390	5.26	7	1	9
31	R:R:T391	5.3475	4	1	6
32	R:R:Y393	5.1075	4	0	9
33	R:R:F396	3.7025	4	0	4
34	R:R:L413	7.11	4	0	7
35	R:R:W416	5.198	5	5	7
36	R:R:N431	7.1525	4	1	9
37	R:R:Y435	5.416	5	1	9
38	R:R:F442	5.1925	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E20	R:R:P22	11.1619	4.72	No	Yes	5	4	4
2	R:R:P22	R:R:W416	16.6522	9.46	Yes	Yes	5	4	7
3	R:R:F396	R:R:W416	27.2541	3.01	Yes	Yes	0	4	7
4	R:R:F396	R:R:I395	62.9092	3.77	Yes	No	0	4	5
5	R:R:I395	R:R:T391	65.3546	4.56	No	Yes	0	5	6
6	R:R:L387	R:R:T391	55.2023	2.95	Yes	Yes	1	6	6
7	R:R:F386	R:R:L387	65.5597	3.65	Yes	Yes	1	9	6
8	R:R:F386	R:R:L113	100	2.44	Yes	Yes	1	9	8
9	R:R:L113	R:R:L64	15.4374	5.54	Yes	Yes	1	8	9
10	R:R:D68	R:R:L64	34.1642	8.14	Yes	Yes	1	9	9
11	R:R:D68	R:R:N41	65.7017	4.04	Yes	Yes	0	9	9
12	R:R:G37	R:R:N41	59.391	3.39	No	Yes	0	9	9
13	R:R:G37	R:R:P39	57.8055	2.03	No	No	0	9	7
14	R:R:L38	R:R:P39	54.7448	3.28	Yes	No	0	7	7
15	R:R:F34	R:R:L38	46.0992	8.53	No	Yes	0	7	7
16	R:R:F34	R:R:L75	44.0404	2.44	No	Yes	0	7	9
17	R:R:L30	R:R:L75	15.6741	8.3	Yes	Yes	2	6	9
18	R:R:L113	R:R:N431	18.3009	8.24	Yes	Yes	1	8	9
19	R:R:D68	R:R:N431	40.8456	8.08	Yes	Yes	1	9	9
20	R:R:L75	R:R:T33	18.4823	2.95	Yes	Yes	2	9	8
21	R:R:L38	R:R:L69	16.9835	1.38	Yes	No	7	7	7
22	R:R:L45	R:R:L69	15.5715	1.38	No	No	0	8	7
23	R:R:L45	R:R:T65	14.4829	1.47	No	No	0	8	9
24	R:R:T65	R:R:V44	13.4496	3.17	No	No	0	9	9
25	R:R:L113	R:R:Y435	75.1755	9.38	Yes	Yes	1	8	9
26	R:R:I116	R:R:Y435	89.4376	6.04	Yes	Yes	1	9	9
27	R:R:I116	R:R:W60	95.5904	3.52	Yes	Yes	0	9	8
28	R:R:A139	R:R:W60	36.0969	5.19	No	Yes	0	7	8
29	R:R:A139	R:R:I59	34.6849	3.25	No	Yes	0	7	6
30	R:R:I59	R:R:T58	36.7989	1.52	Yes	Yes	0	6	8
31	R:R:M52	R:R:T58	30.8038	4.52	No	Yes	0	9	8
32	R:R:D441	R:R:M52	28.3269	2.77	No	No	0	7	9
33	R:R:D441	R:R:F442	25.9131	3.58	No	Yes	0	7	9
34	R:R:F442	R:R:V44	11.8798	7.87	Yes	No	0	9	9
35	R:R:F442	R:R:V47	19.5551	6.55	Yes	Yes	0	9	8
36	R:R:D119	R:R:W60	53.1987	5.58	No	Yes	0	9	8
37	R:R:D119	R:R:R134	22.4659	9.53	No	Yes	4	9	9
38	R:R:C143	R:R:W60	11.3907	2.61	No	Yes	0	8	8
39	R:R:C143	R:R:H63	10.026	16.22	No	Yes	0	8	8
40	R:R:I142	R:R:W60	16.4787	5.87	No	Yes	0	5	8
41	R:R:I142	R:R:I146	14.688	2.94	No	No	0	5	8
42	R:R:D68	R:R:S428	11.4696	7.36	Yes	No	0	9	9
43	R:R:F345	R:R:T391	14.9878	10.38	No	Yes	1	9	6
44	R:R:F345	R:R:H394	15.8555	7.92	No	No	0	9	9
45	R:R:H394	R:R:W390	20.1152	6.35	No	Yes	0	9	9
46	R:R:M106	R:R:W390	78.2125	5.82	No	Yes	0	9	9
47	R:R:I102	R:R:M106	76.7058	4.37	Yes	No	0	8	9
48	R:R:F386	R:R:W390	62.8619	4.01	Yes	Yes	1	9	9
49	R:R:I102	R:R:I98	72.0912	4.42	Yes	No	0	8	8
50	R:R:C95	R:R:W88	37.1145	5.22	Yes	Yes	3	9	9
51	R:R:C95	R:R:P99	67.4686	3.77	Yes	No	0	9	8
52	R:R:I98	R:R:P99	69.1015	8.47	No	No	0	8	8
53	R:R:H81	R:R:W88	21.3457	20.1	No	Yes	0	7	9
54	R:R:G86	R:R:H81	19.4447	7.94	No	No	0	7	7
55	R:R:P89	R:R:W88	15.2323	2.7	No	Yes	0	8	9
56	R:R:G86	R:R:Q87	17.3464	6.58	No	Yes	0	7	6
57	R:R:H169	R:R:Q87	10.9569	6.18	No	Yes	0	3	6
58	R:R:P89	R:R:Y90	10.9569	1.39	No	No	0	8	7
59	R:R:C95	R:R:R161	23.7832	5.57	Yes	Yes	3	9	8
60	R:R:K96	R:R:R161	15.6741	12.38	No	Yes	3	8	8
61	R:R:F158	R:R:K96	13.6704	12.41	No	No	0	8	8
62	R:R:F158	R:R:S100	11.4301	2.64	No	No	0	8	8
63	R:R:W390	R:R:Y393	34.3457	3.86	Yes	Yes	0	9	9
64	R:R:R340	R:R:Y393	28.7292	8.23	No	Yes	0	9	9
65	R:R:I336	R:R:R340	20.7778	2.51	No	No	0	7	9
66	R:R:I336	R:R:P156	12.574	3.39	No	No	0	7	9
67	R:R:I155	R:R:P156	10.6808	3.39	No	No	0	5	9
68	R:R:P348	R:R:V110	13.915	3.53	No	No	0	9	9
69	R:R:F111	R:R:I146	13.418	2.51	No	No	0	8	8
70	R:R:V382	R:R:Y435	14.4987	5.05	Yes	Yes	0	8	9
71	R:R:D119	R:R:V123	29.3366	4.38	No	No	4	9	5
72	R:R:C130	R:R:R134	20.7383	2.79	No	Yes	4	7	9
73	R:R:C130	R:R:W129	17.0072	2.61	No	Yes	4	7	6
74	R:R:V123	R:R:V124	29.2814	1.6	No	No	0	5	9
75	R:R:F125	R:R:V124	27.5381	2.62	No	No	0	6	9
76	R:R:F125	R:R:R362	24.154	3.21	No	No	0	6	7
77	R:R:F111	R:R:V343	11.5248	1.31	No	No	0	8	4
78	R:R:F368	R:R:R362	20.7305	2.14	No	No	0	5	7
79	R:R:F368	R:R:M363	15.3901	13.68	No	No	0	5	7
80	R:R:M363	R:R:Q372	11.6116	2.72	No	No	0	7	5
81	R:R:N427	R:R:W390	31.3166	7.91	No	Yes	0	9	9
82	R:R:C389	R:R:N427	11.5958	11.02	No	No	0	9	9
83	R:R:F396	R:R:L399	32.5708	2.44	Yes	No	0	4	9
84	R:R:L399	R:R:L413	27.2383	9.69	No	Yes	0	9	7
85	R:R:L413	R:R:T403	19.4131	5.9	Yes	No	0	7	2
86	R:R:L409	R:R:T403	16.6995	4.42	No	No	0	3	2
87	R:R:L409	R:R:T407	13.9544	1.47	No	No	0	3	7
88	R:R:P408	R:R:T407	11.1935	3.5	No	No	0	4	7
89	R:R:L64	R:R:Y435	25.6291	3.52	Yes	Yes	1	9	9
90	R:R:N427	R:R:N431	35.3633	8.17	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8I9S_nogp

PDB Summary
PDB	8I9S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	255
Number of Links	285
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	11
Number of Nodes involved in Communities	63
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	34737
Length Of Smallest Path	3
Average Path Length	13.5732
Length of Longest Path	31
Minimum Path Strength	1.16
Average Path Strength	4.86974
Maximum Path Strength	14.02
Minimum Path Correlation	0.7
Average Path Correlation	0.924878
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	50.9728
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.8791
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8I9S_nogp_Chain_R N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I9S_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.