psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E20	R:R:V23	9.98	No	No	0	4	4
2	R:R:P21	R:R:P22	5.84	No	Yes	0	6	4
3	R:R:P22	R:R:S415	8.91	Yes	No	5	4	5
4	R:R:P22	R:R:W416	12.16	Yes	Yes	5	4	7
5	R:R:L25	R:R:V419	4.47	No	No	0	5	5
6	R:R:A422	R:R:S26	3.42	No	No	0	8	8
7	R:R:L79	R:R:M27	7.07	No	No	0	6	6
8	R:R:L30	R:R:L79	4.15	No	No	0	6	6
9	L:L:?1	R:R:L30	6.66	Yes	No	0	0	6
10	R:R:C429	R:R:T33	5.07	No	No	0	9	8
11	R:R:F34	R:R:L38	4.87	Yes	No	0	7	7
12	R:R:F34	R:R:L75	3.65	Yes	No	0	7	9
13	R:R:F34	R:R:P76	4.33	Yes	No	0	7	9
14	R:R:F433	R:R:L36	4.87	No	No	0	6	8
15	R:R:L38	R:R:P39	3.28	No	No	0	7	7
16	R:R:N41	R:R:T65	5.85	Yes	No	0	9	9
17	R:R:D68	R:R:N41	9.42	No	Yes	0	9	9
18	R:R:L69	R:R:N41	4.12	No	Yes	0	7	9
19	R:R:N41	R:R:P432	9.77	Yes	No	0	9	9
20	R:R:I450	R:R:L43	4.28	No	No	0	4	8
21	R:R:T65	R:R:V44	7.93	No	Yes	0	9	9
22	R:R:A436	R:R:V44	5.09	No	Yes	6	8	9
23	R:R:F442	R:R:V44	7.87	Yes	Yes	6	9	9
24	R:R:V47	R:R:W46	3.68	Yes	Yes	0	8	6
25	R:R:L50	R:R:W46	4.56	No	Yes	2	4	6
26	R:R:K51	R:R:W46	10.44	No	Yes	2	9	6
27	R:R:S449	R:R:W46	3.71	No	Yes	2	9	6
28	R:R:I453	R:R:W46	4.7	No	Yes	0	7	6
29	R:R:F442	R:R:V47	5.24	Yes	Yes	0	9	8
30	R:R:A446	R:R:V47	3.39	No	Yes	0	8	8
31	R:R:A48	R:R:F442	4.16	No	Yes	0	7	9
32	R:R:K51	R:R:L50	4.23	No	No	2	9	4
33	R:R:K51	R:R:S449	4.59	No	No	2	9	9
34	R:R:F442	R:R:M52	7.46	Yes	No	0	9	9
35	R:R:L62	R:R:R54	3.64	No	No	0	8	7
36	R:R:T55	R:R:T58	7.85	No	No	0	9	8
37	R:R:R134	R:R:V56	10.46	Yes	No	0	9	8
38	R:R:A139	R:R:I59	4.87	No	No	0	7	6
39	R:R:C140	R:R:I59	3.27	No	No	0	4	6
40	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
41	R:R:I116	R:R:W60	3.52	Yes	Yes	0	9	8
42	R:R:D119	R:R:W60	8.93	No	Yes	0	9	8
43	R:R:A139	R:R:W60	3.89	No	Yes	0	7	8
44	R:R:I142	R:R:W60	5.87	No	Yes	0	5	8
45	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
46	R:R:H63	R:R:L112	3.86	No	No	0	8	9
47	R:R:C143	R:R:H63	16.22	No	No	0	8	8
48	R:R:H63	R:R:W147	7.41	No	Yes	0	8	9
49	R:R:L112	R:R:L64	4.15	No	Yes	0	9	9
50	R:R:L113	R:R:L64	5.54	No	Yes	1	8	9
51	R:R:L64	R:R:N431	6.87	Yes	Yes	1	9	9
52	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
53	R:R:L66	R:R:W147	3.42	No	Yes	0	4	9
54	R:R:D68	R:R:S428	10.31	No	No	0	9	9
55	R:R:D68	R:R:N431	8.08	No	Yes	0	9	9
56	R:R:L70	R:R:N105	10.98	No	No	0	6	9
57	R:R:C71	R:R:S428	6.89	No	No	0	8	9
58	R:R:I102	R:R:S74	4.64	No	No	0	8	9
59	R:R:F77	R:R:W88	6.01	No	No	0	8	9
60	R:R:F77	R:R:I98	5.02	No	Yes	0	8	8
61	L:L:?1	R:R:S78	10.32	Yes	No	0	0	8
62	L:L:?1	R:R:H81	22.98	Yes	No	0	0	7
63	R:R:L84	R:R:W88	4.56	No	No	0	8	9
64	R:R:N170	R:R:Q87	3.96	No	No	0	4	6
65	R:R:P89	R:R:W88	5.4	No	No	0	8	9
66	R:R:C95	R:R:P89	3.77	No	No	0	9	8
67	R:R:K96	R:R:R92	11.14	No	No	7	8	1
68	R:R:E162	R:R:R92	9.3	No	No	7	5	1
69	R:R:F93	R:R:L97	7.31	No	No	0	4	6
70	R:R:I98	R:R:L94	4.28	Yes	No	0	8	8
71	R:R:C172	R:R:C95	7.28	No	No	0	8	9
72	R:R:F158	R:R:K96	6.2	No	No	0	8	8
73	R:R:E162	R:R:K96	9.45	No	No	7	5	8
74	R:R:I101	R:R:L97	4.28	No	No	0	5	6
75	R:R:I98	R:R:P99	3.39	Yes	No	1	8	8
76	L:L:?1	R:R:I98	3.93	Yes	Yes	1	0	8
77	R:R:P99	R:R:R161	12.97	No	Yes	1	8	8
78	L:L:?1	R:R:P99	7.9	Yes	No	1	0	8
79	R:R:C154	R:R:S100	3.44	No	No	0	8	8
80	R:R:S100	R:R:V157	6.46	No	Yes	0	8	9
81	R:R:F158	R:R:S100	3.96	No	No	0	8	8
82	R:R:I101	R:R:N105	4.25	No	No	0	5	9
83	L:L:?1	R:R:I102	3.93	Yes	No	0	0	8
84	R:R:V103	R:R:V157	4.81	No	Yes	1	5	9
85	L:L:?1	R:R:V103	4.1	Yes	No	1	0	5
86	R:R:F151	R:R:L104	3.65	No	No	0	5	8
87	R:R:C154	R:R:L104	7.94	No	No	0	8	8
88	R:R:M106	R:R:W390	6.98	No	Yes	0	9	9
89	R:R:F107	R:R:M153	3.73	No	Yes	0	8	8
90	R:R:F107	R:R:R340	7.48	No	Yes	0	8	9
91	R:R:A108	R:R:W147	6.48	No	Yes	0	9	9
92	R:R:P348	R:R:V110	3.53	No	No	0	9	9
93	R:R:F386	R:R:V110	3.93	No	No	1	9	9
94	R:R:V110	R:R:W390	7.36	No	Yes	1	9	9
95	R:R:F111	R:R:M153	3.73	No	Yes	0	8	8
96	R:R:I146	R:R:L112	4.28	No	No	0	8	9
97	R:R:L113	R:R:N431	9.61	No	Yes	1	8	9
98	R:R:L113	R:R:Y435	8.21	No	Yes	1	8	9
99	R:R:P348	R:R:T114	6.99	No	No	0	9	8
100	R:R:I351	R:R:T114	4.56	No	No	0	6	8
101	R:R:I116	R:R:R120	6.26	Yes	No	1	9	9
102	R:R:I116	R:R:Y435	4.84	Yes	Yes	1	9	9
103	R:R:M352	R:R:S117	6.13	No	No	1	8	9
104	R:R:C355	R:R:S117	3.44	No	No	0	9	9
105	R:R:S117	R:R:Y356	5.09	No	Yes	1	9	9
106	R:R:I351	R:R:L118	5.71	No	No	0	6	8
107	R:R:D119	R:R:V123	4.38	No	No	3	9	5
108	R:R:D119	R:R:R134	11.91	No	Yes	3	9	9
109	R:R:R120	R:R:Y356	8.23	No	Yes	1	9	9
110	R:R:R120	R:R:Y435	6.17	No	Yes	1	9	9
111	R:R:C121	R:R:C355	7.28	No	No	0	9	9
112	R:R:C121	R:R:F358	4.19	No	Yes	0	9	6
113	R:R:C130	R:R:L122	4.76	No	No	0	7	7
114	R:R:C130	R:R:V123	5.12	No	No	3	7	5
115	R:R:R134	R:R:V123	6.54	Yes	No	3	9	5
116	R:R:F358	R:R:V124	5.24	Yes	Yes	4	6	9
117	R:R:I359	R:R:V124	6.14	No	Yes	0	9	9
118	R:R:R362	R:R:V124	6.54	Yes	Yes	4	7	9
119	R:R:F125	R:R:K126	9.93	No	No	0	6	6
120	R:R:F125	R:R:F358	8.57	No	Yes	4	6	6
121	R:R:F125	R:R:R362	4.28	No	Yes	4	6	7
122	R:R:H133	R:R:W129	17.98	No	No	0	8	6
123	R:R:C130	R:R:R134	4.18	No	Yes	3	7	9
124	R:R:H133	R:R:N132	6.38	No	No	0	8	8
125	R:R:C140	R:R:G137	3.92	No	No	0	4	5
126	R:R:I142	R:R:M138	4.37	No	No	0	5	6
127	R:R:F151	R:R:I155	6.28	No	No	0	5	5
128	R:R:I155	R:R:P156	3.39	No	No	0	5	9
129	R:R:I336	R:R:P156	3.39	No	No	0	7	9
130	R:R:V157	R:R:Y174	3.79	Yes	No	1	9	7
131	R:R:R340	R:R:V157	3.92	Yes	Yes	1	9	9
132	L:L:?1	R:R:V157	5.12	Yes	Yes	1	0	9
133	R:R:V159	R:R:Y160	10.09	No	Yes	0	4	8
134	R:R:T331	R:R:Y160	12.48	No	Yes	8	4	8
135	R:R:P332	R:R:Y160	9.74	No	Yes	8	4	8
136	R:R:C172	R:R:R161	4.18	No	Yes	0	8	8
137	L:L:?1	R:R:R161	4.18	Yes	Yes	1	0	8
138	R:R:E162	R:R:F164	3.5	No	No	0	5	3
139	R:R:I163	R:R:N170	8.5	No	No	0	6	4
140	R:R:C172	R:R:I163	4.91	No	No	0	8	6
141	R:R:F164	R:R:R171	17.1	No	No	0	3	1
142	L:L:?1	R:R:Y174	11.28	Yes	No	1	0	7
143	R:R:P332	R:R:T331	3.5	No	No	8	4	4
144	R:R:L333	R:R:T337	4.42	No	No	0	3	7
145	R:R:L401	R:R:V334	7.45	No	No	0	7	4
146	R:R:I336	R:R:R340	3.76	No	Yes	0	7	9
147	L:L:?1	R:R:R340	4.18	Yes	Yes	1	0	9
148	R:R:F345	R:R:L341	3.65	No	Yes	1	9	6
149	R:R:H394	R:R:L341	5.14	Yes	Yes	1	9	6
150	R:R:F345	R:R:T391	6.49	No	No	0	9	6
151	R:R:F345	R:R:H394	21.5	No	Yes	1	9	9
152	R:R:M352	R:R:Y356	3.59	No	Yes	1	8	9
153	R:R:F386	R:R:M352	7.46	No	No	1	9	8
154	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
155	R:R:V382	R:R:Y356	3.79	No	Yes	0	8	9
156	R:R:V383	R:R:Y356	5.05	No	Yes	0	8	9
157	R:R:F358	R:R:R362	16.03	Yes	Yes	4	6	7
158	R:R:F361	R:R:R365	22.45	No	No	0	4	4
159	R:R:R362	R:R:R365	11.73	Yes	No	0	7	4
160	R:R:F368	R:R:R367	14.97	No	No	0	5	6
161	R:R:K374	R:R:Q372	6.78	No	No	0	9	5
162	R:R:Q372	R:R:T375	5.67	No	No	0	5	7
163	R:R:F376	R:R:V380	6.55	No	No	0	4	3
164	R:R:V382	R:R:Y435	3.79	No	Yes	0	8	9
165	R:R:F430	R:R:V385	3.93	No	No	0	7	7
166	R:R:L434	R:R:V385	5.96	No	No	0	9	7
167	R:R:F386	R:R:W390	9.02	No	Yes	1	9	9
168	R:R:C389	R:R:N427	9.45	No	No	0	9	9
169	R:R:W390	R:R:Y393	5.79	Yes	Yes	1	9	9
170	R:R:H394	R:R:W390	5.29	Yes	Yes	1	9	9
171	R:R:A424	R:R:W390	7.78	No	Yes	1	9	9
172	R:R:N427	R:R:W390	6.78	No	Yes	0	9	9
173	R:R:P392	R:R:T391	5.25	No	No	0	9	6
174	R:R:C420	R:R:P392	3.77	No	No	0	6	9
175	R:R:H394	R:R:Y393	8.71	Yes	Yes	1	9	9
176	R:R:A424	R:R:Y393	4	No	Yes	1	9	9
177	L:L:?1	R:R:Y393	21.76	Yes	Yes	1	0	9
178	R:R:F396	R:R:L413	9.74	No	Yes	0	4	7
179	R:R:C420	R:R:F396	9.78	No	No	0	6	4
180	L:L:?1	R:R:G397	3.53	Yes	No	0	0	8
181	R:R:D404	R:R:E406	9.09	No	No	0	4	1
182	R:R:D404	R:R:T407	5.78	No	No	0	4	7
183	R:R:P408	R:R:T407	3.5	No	No	0	4	7
184	R:R:S415	R:R:W416	6.18	No	Yes	5	5	7
185	R:R:V419	R:R:W416	6.13	No	Yes	0	5	7
186	L:L:?1	R:R:D417	9.33	Yes	No	0	0	8
187	L:L:?1	R:R:H418	6.19	Yes	No	0	0	4
188	L:L:?1	R:R:I421	16.68	Yes	No	0	0	4
189	R:R:N427	R:R:N431	10.9	No	Yes	0	9	9
190	R:R:C429	R:R:F430	5.59	No	No	0	9	7
191	R:R:N431	R:R:Y435	4.65	Yes	Yes	1	9	9
192	R:R:F433	R:R:L437	3.65	No	No	0	6	7
193	R:R:A436	R:R:F442	6.93	No	Yes	6	8	9
194	R:R:D441	R:R:K445	4.15	No	No	0	7	7
195	R:R:K444	R:R:Q448	6.78	No	No	0	5	7
196	R:R:G452	R:R:Q451	4.93	No	No	0	6	6
197	R:R:E455	R:R:Q451	5.1	No	No	0	9	6
198	R:R:A422	R:R:I29	3.25	No	No	0	8	7
199	R:R:S26	R:R:V419	3.23	No	No	0	8	5
200	R:R:S31	R:R:V28	3.23	No	No	0	7	6
201	R:R:G86	R:R:H81	3.18	No	No	0	7	7
202	R:R:C429	R:R:L36	3.17	No	No	0	9	8
203	R:R:T375	R:R:V360	3.17	No	No	0	7	6
204	R:R:A422	R:R:L30	3.15	No	No	0	8	6
205	R:R:A83	R:R:L84	3.15	No	No	0	5	8
206	R:R:E20	R:R:P22	3.14	No	Yes	0	4	4
207	R:R:I353	R:R:S349	3.1	No	No	0	5	4
208	R:R:I353	R:R:V383	3.07	No	No	0	5	8
209	R:R:M363	R:R:V124	3.04	No	Yes	0	7	9
210	R:R:M153	R:R:V343	3.04	Yes	No	0	8	4
211	R:R:I395	R:R:T391	3.04	No	No	0	5	6
212	R:R:F107	R:R:G344	3.01	No	No	0	8	9
213	R:R:L82	R:R:S26	3	No	No	0	7	8
214	R:R:L64	R:R:S109	3	Yes	No	0	9	9
215	R:R:L75	R:R:S425	3	No	No	0	9	8
216	R:R:L387	R:R:S349	3	No	No	0	6	4
217	R:R:L413	R:R:S400	3	Yes	No	0	7	2
218	R:R:L43	R:R:V47	2.98	No	Yes	0	8	8
219	R:R:L437	R:R:V44	2.98	No	Yes	0	7	9
220	R:R:L438	R:R:V378	2.98	No	No	0	7	8
221	R:R:L75	R:R:T33	2.95	No	No	0	9	8
222	R:R:L45	R:R:T65	2.95	No	No	0	8	9
223	R:R:L409	R:R:T403	2.95	No	No	0	3	2
224	R:R:I450	R:R:L454	2.85	No	No	0	4	8
225	R:R:D441	R:R:M52	2.77	No	No	0	7	9
226	R:R:A150	R:R:F111	2.77	No	No	0	9	8
227	R:R:L341	R:R:L346	2.77	Yes	No	0	6	8
228	R:R:L399	R:R:L413	2.77	No	Yes	0	9	7
229	R:R:L104	R:R:N105	2.75	No	No	0	8	9
230	R:R:E455	R:R:L454	2.65	No	No	0	9	8
231	R:R:R377	R:R:S373	2.64	No	No	0	5	4
232	R:R:F111	R:R:V149	2.62	No	No	0	8	4
233	R:R:F376	R:R:V360	2.62	No	No	0	4	6
234	R:R:R54	R:R:T58	2.59	No	No	0	7	8
235	R:R:A67	R:R:W147	2.59	No	Yes	0	9	9
236	R:R:I59	R:R:R54	2.51	No	No	0	6	7
237	R:R:F61	R:R:I116	2.51	No	Yes	0	8	9
238	R:R:K440	R:R:R443	2.48	No	No	0	7	9
239	R:R:T412	R:R:W416	2.43	No	Yes	0	6	7
240	R:R:F61	R:R:N57	2.42	No	No	0	8	8
241	R:R:I336	R:R:Y160	2.42	No	Yes	0	7	8
242	R:R:F361	R:R:Q364	2.34	No	No	0	4	5
243	R:R:K126	R:R:W129	2.32	No	No	0	6	6
244	R:R:R443	R:R:R447	2.13	No	No	0	9	5
245	R:R:G37	R:R:P39	2.03	No	No	0	9	7
246	R:R:G40	R:R:P39	2.03	No	No	0	9	7
247	R:R:C72	R:R:G37	1.96	No	No	0	8	9
248	R:R:A369	R:R:G366	1.95	No	No	0	5	2
249	R:R:G397	R:R:T337	1.82	No	No	0	8	7
250	R:R:G410	R:R:T403	1.82	No	No	0	3	2
251	R:R:G49	R:R:L50	1.71	No	No	0	7	4
252	R:R:G49	R:R:L62	1.71	No	No	0	7	8
253	R:R:G410	R:R:L413	1.71	No	Yes	0	3	7
254	R:R:A379	R:R:V360	1.7	No	No	0	7	6
255	R:R:A426	R:R:T33	1.68	No	No	0	8	8
256	R:R:K126	R:R:P127	1.67	No	No	0	6	9
257	R:R:L347	R:R:P348	1.64	No	No	0	7	9
258	R:R:L423	R:R:P392	1.64	No	No	0	8	9
259	R:R:D404	R:R:P405	1.61	No	No	0	4	4
260	R:R:V136	R:R:V56	1.6	No	No	0	7	8
261	R:R:V342	R:R:V343	1.6	No	No	0	6	4
262	R:R:V381	R:R:V385	1.6	No	No	0	7	7
263	R:R:I353	R:R:S357	1.55	No	No	0	5	6
264	R:R:I29	R:R:V28	1.54	No	No	0	7	6
265	R:R:I338	R:R:V334	1.54	No	No	0	6	4
266	R:R:I338	R:R:V342	1.54	No	No	0	6	6
267	R:R:K374	R:R:V378	1.52	No	No	0	9	8
268	R:R:M153	R:R:T339	1.51	Yes	No	0	8	8
269	R:R:G173	R:R:R161	1.5	No	Yes	0	1	8
270	R:R:G173	R:R:R171	1.5	No	No	0	1	1
271	R:R:L32	R:R:V28	1.49	No	No	0	6	6
272	R:R:L341	R:R:V398	1.49	Yes	No	0	6	7
273	R:R:L402	R:R:V398	1.49	No	No	0	5	7
274	R:R:L409	R:R:T407	1.47	No	No	0	3	7
275	R:R:N170	R:R:T165	1.46	No	No	0	4	4
276	R:R:I128	R:R:N132	1.42	No	No	0	7	8
277	R:R:M138	R:R:N135	1.4	No	No	0	6	5
278	R:R:L38	R:R:L73	1.38	No	No	0	7	8
279	R:R:K445	R:R:Q53	1.36	No	No	0	7	6
280	R:R:K445	R:R:Q448	1.36	No	No	0	7	7
281	R:R:E406	R:R:K411	1.35	No	No	0	1	2
282	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
283	R:R:I450	R:R:R447	1.25	No	No	0	4	5
284	R:R:H169	R:R:Q87	1.24	No	No	0	3	6
285	R:R:F34	R:R:L35	1.22	Yes	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P22	7.5125	4	5	4
2	R:R:F34	3.5175	4	0	7
3	R:R:N41	7.29	4	0	9
4	R:R:V44	5.9675	4	6	9
5	R:R:W46	5.418	5	2	6
6	R:R:V47	3.8225	4	0	8
7	R:R:W60	5.00333	6	0	8
8	R:R:L64	4.616	5	1	9
9	R:R:I98	4.155	4	1	8
10	R:R:I116	4.2825	4	1	9
11	R:R:V124	5.24	4	4	9
12	R:R:R134	8.2725	4	3	9
13	R:R:W147	4.975	4	0	9
14	R:R:M153	3.0025	4	0	8
15	R:R:V157	4.82	5	1	9
16	R:R:Y160	8.6825	4	8	8
17	R:R:R161	5.7075	4	1	8
18	R:R:R340	4.835	4	1	9
19	R:R:L341	3.2625	4	1	6
20	R:R:Y356	4.95833	6	1	9
21	R:R:F358	8.5075	4	4	6
22	R:R:R362	9.645	4	4	7
23	R:R:W390	7	7	1	9
24	R:R:Y393	10.065	4	1	9
25	R:R:H394	10.16	4	1	9
26	R:R:L413	4.305	4	0	7
27	R:R:W416	6.725	4	5	7
28	R:R:N431	8.022	5	1	9
29	R:R:Y435	5.19667	6	1	9
30	R:R:F442	6.332	5	6	9
31	L:L:?1	8.87938	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V419	R:R:W416	11.789	6.13	No	Yes	0	5	7
2	R:R:A422	R:R:S26	18.0498	3.42	No	No	0	8	8
3	R:R:S26	R:R:V419	15.0393	3.23	No	No	0	8	5
4	R:R:A422	R:R:L30	25.8092	3.15	No	No	0	8	6
5	L:L:?1	R:R:L30	30.1052	6.66	Yes	No	0	0	6
6	R:R:C429	R:R:L36	33.0825	3.17	No	No	0	9	8
7	R:R:F433	R:R:L36	34.7742	4.87	No	No	0	6	8
8	R:R:F433	R:R:L437	36.4726	3.65	No	No	0	6	7
9	R:R:L437	R:R:V44	38.1577	2.98	No	Yes	0	7	9
10	R:R:T65	R:R:V44	71.2335	7.93	No	Yes	0	9	9
11	R:R:N41	R:R:T65	73.7378	5.85	Yes	No	0	9	9
12	R:R:D68	R:R:N41	77.5143	9.42	No	Yes	0	9	9
13	R:R:D68	R:R:N431	81.2109	8.08	No	Yes	0	9	9
14	R:R:N427	R:R:N431	80.9778	10.9	No	Yes	0	9	9
15	R:R:N427	R:R:W390	81.404	6.78	No	Yes	0	9	9
16	R:R:W390	R:R:Y393	85.7533	5.79	Yes	Yes	1	9	9
17	L:L:?1	R:R:Y393	100	21.76	Yes	Yes	1	0	9
18	R:R:C429	R:R:T33	24.324	5.07	No	No	0	9	8
19	R:R:L75	R:R:T33	20.7273	2.95	No	No	0	9	8
20	R:R:F34	R:R:L75	17.0774	3.65	Yes	No	0	7	9
21	R:R:F34	R:R:L38	11.5026	4.87	Yes	No	0	7	7
22	R:R:F442	R:R:V44	39.2767	7.87	Yes	Yes	6	9	9
23	R:R:F442	R:R:V47	27.0547	5.24	Yes	Yes	0	9	8
24	R:R:L43	R:R:V47	16.8243	2.98	No	Yes	0	8	8
25	R:R:I450	R:R:L43	14.986	4.28	No	No	0	4	8
26	R:R:V47	R:R:W46	10.7699	3.68	Yes	Yes	0	8	6
27	R:R:F442	R:R:M52	11.5026	7.46	Yes	No	0	9	9
28	R:R:N431	R:R:Y435	56.4606	4.65	Yes	Yes	1	9	9
29	R:R:I116	R:R:Y435	28.6666	4.84	Yes	Yes	1	9	9
30	R:R:I116	R:R:W60	35.2338	3.52	Yes	Yes	0	9	8
31	R:R:A139	R:R:W60	15.8186	3.89	No	Yes	0	7	8
32	R:R:A139	R:R:I59	14.5131	4.87	No	No	0	7	6
33	R:R:I59	R:R:R54	11.416	2.51	No	No	0	6	7
34	R:R:D119	R:R:W60	15.0526	8.93	No	Yes	0	9	8
35	R:R:L112	R:R:L64	13.0012	4.15	No	Yes	0	9	9
36	R:R:L64	R:R:N431	11.8223	6.87	Yes	Yes	1	9	9
37	L:L:?1	R:R:V157	20.2478	5.12	Yes	Yes	1	0	9
38	R:R:S100	R:R:V157	20.4809	6.46	No	Yes	0	8	9
39	R:R:C154	R:R:S100	12.9812	3.44	No	No	0	8	8
40	R:R:C154	R:R:L104	11.3827	7.94	No	No	0	8	8
41	L:L:?1	R:R:I98	11.2562	3.93	Yes	Yes	1	0	8
42	L:L:?1	R:R:R161	20.3144	4.18	Yes	Yes	1	0	8
43	R:R:C172	R:R:R161	13.4141	4.18	No	Yes	0	8	8
44	L:L:?1	R:R:R340	30.8645	4.18	Yes	Yes	1	0	9
45	R:R:I336	R:R:R340	12.7814	3.76	No	Yes	0	7	9
46	R:R:F107	R:R:R340	19.6417	7.48	No	Yes	0	8	9
47	R:R:F107	R:R:M153	16.4713	3.73	No	Yes	0	8	8
48	R:R:F386	R:R:W390	30.5515	9.02	No	Yes	1	9	9
49	R:R:F386	R:R:M352	32.3165	7.46	No	No	1	9	8
50	R:R:M352	R:R:Y356	16.5179	3.59	No	Yes	1	8	9
51	R:R:R120	R:R:Y356	26.1756	8.23	No	Yes	1	9	9
52	R:R:R120	R:R:Y435	16.3514	6.17	No	Yes	1	9	9
53	R:R:M352	R:R:S117	15.9518	6.13	No	No	1	8	9
54	R:R:C355	R:R:S117	37.2985	3.44	No	No	0	9	9
55	R:R:C121	R:R:C355	35.327	7.28	No	No	0	9	9
56	R:R:C121	R:R:F358	33.3289	4.19	No	Yes	0	9	6
57	R:R:F125	R:R:F358	16.9775	8.57	No	Yes	4	6	6
58	R:R:F125	R:R:K126	15.2391	9.93	No	No	0	6	6
59	R:R:K126	R:R:W129	10.9498	2.32	No	No	0	6	6
60	R:R:H394	R:R:Y393	14.4465	8.71	Yes	Yes	1	9	9
61	R:R:F345	R:R:H394	29.9387	21.5	No	Yes	1	9	9
62	R:R:F345	R:R:T391	28.953	6.49	No	No	0	9	6
63	R:R:A379	R:R:Y356	19.3553	4	No	Yes	0	7	9
64	R:R:V382	R:R:Y356	16.3314	3.79	No	Yes	0	8	9
65	R:R:V382	R:R:Y435	16.5512	3.79	No	Yes	0	8	9
66	R:R:V383	R:R:Y356	10.9498	5.05	No	Yes	0	8	9
67	R:R:A379	R:R:V360	17.2372	1.7	No	No	0	7	6
68	R:R:T375	R:R:V360	10.8033	3.17	No	No	0	7	6
69	R:R:P392	R:R:T391	25.9291	5.25	No	No	0	9	6
70	R:R:C420	R:R:P392	22.852	3.77	No	No	0	6	9
71	R:R:C420	R:R:F396	21.2868	9.78	No	No	0	6	4
72	R:R:F396	R:R:L413	19.7016	9.74	No	Yes	0	4	7
73	R:R:L409	R:R:T407	10.1838	1.47	No	No	0	3	7
74	R:R:L409	R:R:T403	11.8356	2.95	No	No	0	3	2
75	R:R:G410	R:R:T403	13.4741	1.82	No	No	0	3	2
76	R:R:G410	R:R:L413	15.0992	1.71	No	Yes	0	3	7
77	R:R:S117	R:R:Y356	23.2983	5.09	No	Yes	1	9	9
78	R:R:H394	R:R:W390	23.2516	5.29	Yes	Yes	1	9	9
79	R:R:I116	R:R:R120	10.1971	6.26	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L30	R:R:L79	4.15	0	No	No	6	6	1	2
L:L:?1	R:R:L30	6.66	1	Yes	No	0	6	0	1
R:R:I102	R:R:S74	4.64	0	No	No	8	9	1	2
R:R:F77	R:R:I98	5.02	0	No	Yes	8	8	2	1
L:L:?1	R:R:S78	10.32	1	Yes	No	0	8	0	1
L:L:?1	R:R:H81	22.98	1	Yes	No	0	7	0	1
R:R:I98	R:R:L94	4.28	1	Yes	No	8	8	1	2
R:R:I98	R:R:P99	3.39	1	Yes	No	8	8	1	1
L:L:?1	R:R:I98	3.93	1	Yes	Yes	0	8	0	1
R:R:P99	R:R:R161	12.97	1	No	Yes	8	8	1	1
L:L:?1	R:R:P99	7.9	1	Yes	No	0	8	0	1
R:R:S100	R:R:V157	6.46	0	No	Yes	8	9	2	1
L:L:?1	R:R:I102	3.93	1	Yes	No	0	8	0	1
R:R:V103	R:R:V157	4.81	1	No	Yes	5	9	1	1
L:L:?1	R:R:V103	4.1	1	Yes	No	0	5	0	1
R:R:F107	R:R:R340	7.48	0	No	Yes	8	9	2	1
R:R:V157	R:R:Y174	3.79	1	Yes	No	9	7	1	1
R:R:R340	R:R:V157	3.92	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:V157	5.12	1	Yes	Yes	0	9	0	1
R:R:C172	R:R:R161	4.18	0	No	Yes	8	8	2	1
L:L:?1	R:R:R161	4.18	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y174	11.28	1	Yes	No	0	7	0	1
R:R:I336	R:R:R340	3.76	0	No	Yes	7	9	2	1
L:L:?1	R:R:R340	4.18	1	Yes	Yes	0	9	0	1
R:R:W390	R:R:Y393	5.79	1	Yes	Yes	9	9	2	1
R:R:H394	R:R:W390	5.29	1	Yes	Yes	9	9	2	2
R:R:A424	R:R:W390	7.78	1	No	Yes	9	9	2	2
R:R:H394	R:R:Y393	8.71	1	Yes	Yes	9	9	2	1
R:R:A424	R:R:Y393	4	1	No	Yes	9	9	2	1
L:L:?1	R:R:Y393	21.76	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G397	3.53	1	Yes	No	0	8	0	1
L:L:?1	R:R:D417	9.33	1	Yes	No	0	8	0	1
L:L:?1	R:R:H418	6.19	1	Yes	No	0	4	0	1
L:L:?1	R:R:I421	16.68	1	Yes	No	0	4	0	1
R:R:G86	R:R:H81	3.18	0	No	No	7	7	2	1
R:R:A422	R:R:L30	3.15	0	No	No	8	6	2	1
R:R:G397	R:R:T337	1.82	0	No	No	8	7	1	2
R:R:G173	R:R:R161	1.5	0	No	Yes	1	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IPV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.27
Number of Linked Nodes	258
Number of Links	285
Number of Hubs	31
Number of Links mediated by Hubs	128
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	35515
Length Of Smallest Path	3
Average Path Length	12.8192
Length of Longest Path	32
Minimum Path Strength	1.36
Average Path Strength	6.41239
Maximum Path Strength	18.7375
Minimum Path Correlation	0.7
Average Path Correlation	0.924603
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	50.3959
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.5963
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>9IPV_nogp_Chain_R E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G I L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KVP	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-	Go/β1/γ2	2.79	2025-11-26	10.1101/2025.05.26.656101
	9KVP (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-		2.79	2025-11-26	10.1101/2025.05.26.656101
	9KZ2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-	Go/β1/γ2	3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-		3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-	Go/β1/γ2	3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZ8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-		3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZK	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-	Go/β1/γ2	3.54	2025-11-26	10.1101/2025.05.26.656101
	9KZK (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-		3.54	2025-11-26	10.1101/2025.05.26.656101
	9L0H	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-	Go/β1/γ2	3.57	2025-11-26	10.1101/2025.05.26.656101
	9L0H (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-		3.57	2025-11-26	10.1101/2025.05.26.656101
	9UMJ	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-	Go/β1/γ2	3.38	2025-11-26	10.1101/2025.05.26.656101
	9UMJ (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-		3.38	2025-11-26	10.1101/2025.05.26.656101
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWF (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9KV6	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV6 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	3.17	2025-11-26	10.1101/2025.05.26.656101
	9KV8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		3.17	2025-11-26	10.1101/2025.05.26.656101

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9IPV_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.