psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E20	R:R:W18	4.36	No	No	0	4	1
2	R:R:E20	R:R:P21	3.14	No	No	0	4	6
3	R:R:P21	R:R:P22	5.84	No	No	0	6	4
4	R:R:P22	R:R:W416	5.4	No	Yes	0	4	7
5	R:R:H418	R:R:P22	3.05	No	No	0	4	4
6	R:R:M27	R:R:V23	3.04	No	No	0	6	4
7	R:R:H418	R:R:S26	9.76	No	No	0	4	8
8	R:R:A422	R:R:I29	4.87	No	No	0	8	7
9	R:R:L30	R:R:L75	4.15	No	Yes	0	6	9
10	R:R:L32	R:R:L36	8.3	No	No	0	6	8
11	R:R:F430	R:R:L32	3.65	No	No	0	7	6
12	R:R:C72	R:R:T33	3.38	No	No	0	8	8
13	R:R:L75	R:R:T33	4.42	Yes	No	4	9	8
14	R:R:S425	R:R:T33	3.2	No	No	4	8	8
15	R:R:F34	R:R:L38	8.53	No	Yes	0	7	7
16	R:R:F34	R:R:P76	5.78	No	No	0	7	9
17	R:R:L35	R:R:L36	4.15	No	No	0	6	8
18	R:R:G37	R:R:N41	3.39	No	Yes	0	9	9
19	R:R:C429	R:R:G37	3.92	No	No	0	9	9
20	R:R:L38	R:R:L69	4.15	Yes	No	1	7	7
21	R:R:L38	R:R:L73	4.15	Yes	No	1	7	8
22	R:R:N41	R:R:T65	5.85	Yes	No	0	9	9
23	R:R:D68	R:R:N41	6.73	Yes	Yes	1	9	9
24	R:R:N41	R:R:P432	11.4	Yes	No	1	9	9
25	R:R:L43	R:R:V47	2.98	No	No	0	8	8
26	R:R:I450	R:R:L43	7.14	No	No	0	4	8
27	R:R:T65	R:R:V44	7.93	No	No	0	9	9
28	R:R:F442	R:R:V44	9.18	Yes	No	0	9	9
29	R:R:L50	R:R:W46	6.83	No	Yes	0	4	6
30	R:R:K51	R:R:W46	5.8	No	Yes	5	9	6
31	R:R:S449	R:R:W46	4.94	No	Yes	5	9	6
32	R:R:I453	R:R:W46	4.7	No	Yes	0	7	6
33	R:R:F442	R:R:V47	6.55	Yes	No	0	9	8
34	R:R:K445	R:R:V47	3.04	No	No	0	7	8
35	R:R:A48	R:R:L62	4.73	No	No	0	7	8
36	R:R:G49	R:R:R54	3	No	No	0	7	7
37	R:R:G49	R:R:L62	3.42	No	No	0	7	8
38	R:R:K51	R:R:S449	4.59	No	No	5	9	9
39	R:R:M52	R:R:T58	3.01	No	No	0	9	8
40	R:R:D441	R:R:M52	5.54	No	No	0	7	9
41	R:R:T55	R:R:T58	9.42	No	No	0	9	8
42	R:R:R134	R:R:V56	3.92	No	No	0	9	8
43	R:R:A139	R:R:V56	5.09	No	No	0	7	8
44	R:R:H63	R:R:I59	3.98	Yes	No	0	8	6
45	R:R:A115	R:R:W60	5.19	No	Yes	0	7	8
46	R:R:I116	R:R:W60	7.05	No	Yes	0	9	8
47	R:R:D119	R:R:W60	3.35	No	Yes	0	9	8
48	R:R:A139	R:R:W60	3.89	No	Yes	0	7	8
49	R:R:I142	R:R:W60	4.7	No	Yes	0	5	8
50	R:R:C143	R:R:W60	6.53	No	Yes	0	8	8
51	R:R:A436	R:R:F61	4.16	No	No	0	8	8
52	R:R:H63	R:R:L112	5.14	Yes	No	0	8	9
53	R:R:C143	R:R:H63	14.74	No	Yes	0	8	8
54	R:R:H63	R:R:W147	5.29	Yes	No	0	8	9
55	R:R:D68	R:R:L64	9.5	Yes	No	1	9	9
56	R:R:L113	R:R:L64	5.54	No	No	1	8	9
57	R:R:L64	R:R:Y435	3.52	No	Yes	1	9	9
58	R:R:A67	R:R:S109	3.42	No	No	0	9	9
59	R:R:D68	R:R:S109	2.94	Yes	No	0	9	9
60	R:R:D68	R:R:S428	7.36	Yes	No	1	9	9
61	R:R:D68	R:R:N431	10.77	Yes	No	1	9	9
62	R:R:D68	R:R:P432	4.83	Yes	No	1	9	9
63	R:R:L69	R:R:L73	5.54	No	No	1	7	8
64	R:R:L70	R:R:N105	10.98	No	No	0	6	9
65	R:R:C71	R:R:S428	5.16	No	No	0	8	9
66	R:R:I102	R:R:S74	3.1	Yes	No	0	8	9
67	R:R:L75	R:R:P76	3.28	Yes	No	0	9	9
68	R:R:L75	R:R:S425	12.01	Yes	No	4	9	8
69	R:R:I102	R:R:S78	9.29	Yes	No	0	8	8
70	R:R:I421	R:R:S78	3.1	Yes	No	0	4	8
71	R:R:H81	R:R:W88	12.7	No	Yes	2	7	9
72	R:R:C95	R:R:H81	2.95	Yes	No	2	9	7
73	R:R:H81	R:R:P99	6.1	No	No	0	7	8
74	R:R:L82	R:R:Q85	6.65	No	No	0	7	5
75	R:R:D417	R:R:L82	4.07	No	No	0	8	7
76	R:R:I421	R:R:L82	4.28	Yes	No	0	4	7
77	R:R:H169	R:R:Q87	12.36	Yes	No	0	3	6
78	R:R:W88	R:R:Y90	11.58	Yes	Yes	2	9	7
79	R:R:L94	R:R:W88	9.11	No	Yes	2	8	9
80	R:R:C95	R:R:W88	5.22	Yes	Yes	2	9	9
81	R:R:P89	R:R:Y90	5.56	No	Yes	0	8	7
82	R:R:L94	R:R:Y90	4.69	No	Yes	2	8	7
83	R:R:K96	R:R:R92	8.66	Yes	No	0	8	1
84	R:R:F93	R:R:K96	4.96	No	Yes	6	4	8
85	R:R:F158	R:R:F93	8.57	No	No	6	8	4
86	R:R:I98	R:R:L94	7.14	Yes	No	0	8	8
87	R:R:C95	R:R:R161	4.18	Yes	Yes	0	9	8
88	R:R:C172	R:R:C95	7.28	No	Yes	0	8	9
89	R:R:F158	R:R:K96	12.41	No	Yes	6	8	8
90	R:R:K96	R:R:R161	3.71	Yes	Yes	0	8	8
91	R:R:I101	R:R:L97	4.28	No	No	0	5	6
92	R:R:I98	R:R:P99	5.08	Yes	No	0	8	8
93	R:R:I102	R:R:I98	2.94	Yes	Yes	0	8	8
94	R:R:C154	R:R:S100	5.16	No	No	0	8	8
95	R:R:F158	R:R:S100	5.28	No	No	0	8	8
96	R:R:I101	R:R:N105	4.25	No	No	0	5	9
97	R:R:I102	R:R:M106	2.92	Yes	No	0	8	9
98	R:R:V103	R:R:V157	4.81	No	No	0	5	9
99	R:R:C154	R:R:L104	4.76	No	No	0	8	8
100	R:R:A424	R:R:M106	3.22	No	No	0	9	9
101	R:R:F107	R:R:F111	9.65	Yes	Yes	0	8	8
102	R:R:F107	R:R:M153	9.95	Yes	No	0	8	8
103	R:R:F107	R:R:R340	6.41	Yes	No	0	8	9
104	R:R:A108	R:R:W147	7.78	No	No	0	9	9
105	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
106	R:R:V110	R:R:W390	4.9	No	Yes	0	9	9
107	R:R:F111	R:R:I146	5.02	Yes	No	0	8	8
108	R:R:L113	R:R:Y435	5.86	No	Yes	1	8	9
109	R:R:L118	R:R:T114	2.95	No	No	0	8	8
110	R:R:P348	R:R:T114	3.5	Yes	No	0	9	8
111	R:R:I351	R:R:T114	4.56	No	No	0	6	8
112	R:R:I116	R:R:R120	7.52	No	No	0	9	9
113	R:R:M352	R:R:S117	4.6	No	No	0	8	9
114	R:R:C355	R:R:S117	3.44	No	No	0	9	9
115	R:R:D119	R:R:R134	3.57	No	No	0	9	9
116	R:R:R120	R:R:Y435	8.23	No	Yes	0	9	9
117	R:R:C121	R:R:C355	7.28	No	No	0	9	9
118	R:R:L122	R:R:W129	3.42	No	No	0	7	6
119	R:R:R362	R:R:V124	3.92	No	No	0	7	9
120	R:R:F125	R:R:K126	9.93	No	No	0	6	6
121	R:R:F125	R:R:F358	6.43	No	No	0	6	6
122	R:R:H133	R:R:W129	16.93	No	No	0	8	6
123	R:R:M138	R:R:W129	5.82	No	No	0	6	6
124	R:R:C130	R:R:R134	6.96	No	No	0	7	9
125	R:R:H133	R:R:N132	3.83	No	No	0	8	8
126	R:R:G137	R:R:N135	3.39	No	No	0	5	5
127	R:R:I142	R:R:M138	4.37	No	No	0	5	6
128	R:R:I142	R:R:I146	2.94	No	No	0	5	8
129	R:R:F151	R:R:I155	5.02	No	No	0	5	5
130	R:R:M153	R:R:V343	3.04	No	No	0	8	4
131	R:R:I155	R:R:P156	3.39	No	No	0	5	9
132	R:R:I336	R:R:V157	3.07	No	No	0	7	9
133	R:R:V159	R:R:Y160	5.05	No	No	0	4	8
134	R:R:P332	R:R:Y160	8.34	No	No	0	4	8
135	R:R:G173	R:R:R161	3	No	Yes	0	1	8
136	R:R:R161	R:R:Y174	21.61	Yes	No	0	8	7
137	R:R:E162	R:R:K175	4.05	No	No	0	5	5
138	R:R:I163	R:R:N170	4.25	No	No	0	6	4
139	R:R:F164	R:R:R171	14.97	No	Yes	0	3	1
140	R:R:F164	R:R:G173	3.01	No	No	0	3	1
141	R:R:F164	R:R:K175	12.41	No	No	0	3	5
142	R:R:N170	R:R:T165	2.92	No	No	0	4	4
143	R:R:N168	R:R:T166	4.39	No	No	3	5	1
144	R:R:H169	R:R:T166	13.69	Yes	No	3	3	1
145	R:R:R171	R:R:T166	6.47	Yes	No	3	1	1
146	R:R:D167	R:R:N168	5.39	No	No	0	3	5
147	R:R:H169	R:R:N168	16.58	Yes	No	3	3	5
148	R:R:H169	R:R:R171	5.64	Yes	Yes	3	3	1
149	R:R:F176	R:R:P332	15.89	No	No	0	4	4
150	R:R:P332	R:R:T331	3.5	No	No	0	4	4
151	R:R:L333	R:R:T337	2.95	No	No	0	3	7
152	R:R:L401	R:R:V334	7.45	No	No	0	7	4
153	R:R:I338	R:R:T337	3.04	No	No	0	6	7
154	R:R:L401	R:R:T337	5.9	No	No	0	7	7
155	R:R:R340	R:R:Y393	6.17	No	No	0	9	9
156	R:R:H394	R:R:L341	3.86	No	No	0	9	6
157	R:R:L341	R:R:V398	4.47	No	No	0	6	7
158	R:R:L346	R:R:V342	4.47	No	No	0	8	6
159	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
160	R:R:F345	R:R:S349	5.28	No	No	0	9	4
161	R:R:F345	R:R:T391	6.49	No	No	0	9	6
162	R:R:F345	R:R:H394	13.58	No	No	0	9	9
163	R:R:L347	R:R:P348	3.28	No	Yes	0	7	9
164	R:R:I351	R:R:L347	7.14	No	No	0	6	7
165	R:R:L387	R:R:S349	3	No	No	0	6	4
166	R:R:M352	R:R:Y356	3.59	No	Yes	0	8	9
167	R:R:F386	R:R:M352	8.71	No	No	0	9	8
168	R:R:I353	R:R:V383	3.07	No	No	0	5	8
169	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	9
170	R:R:V382	R:R:Y356	3.79	Yes	Yes	0	8	9
171	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
172	R:R:F358	R:R:R362	13.9	No	No	0	6	7
173	R:R:Q364	R:R:V360	5.73	No	No	0	5	6
174	R:R:F361	R:R:R365	14.97	No	No	0	4	4
175	R:R:M363	R:R:Q372	9.52	No	No	0	7	5
176	R:R:F368	R:R:R367	13.9	No	No	0	5	6
177	R:R:K370	R:R:Q372	4.07	No	No	0	7	5
178	R:R:F376	R:R:V380	9.18	No	No	0	4	3
179	R:R:L438	R:R:V378	2.98	No	No	0	7	8
180	R:R:V382	R:R:Y435	3.79	Yes	Yes	0	8	9
181	R:R:L387	R:R:V383	2.98	No	No	0	6	8
182	R:R:L434	R:R:V385	4.47	No	No	0	9	7
183	R:R:F386	R:R:W390	16.04	No	Yes	0	9	9
184	R:R:C389	R:R:L423	4.76	No	No	0	9	8
185	R:R:C389	R:R:N427	9.45	No	No	0	9	9
186	R:R:H394	R:R:W390	3.17	No	Yes	0	9	9
187	R:R:N427	R:R:W390	12.43	No	Yes	0	9	9
188	R:R:P392	R:R:T391	5.25	No	No	0	9	6
189	R:R:I395	R:R:T391	3.04	No	No	0	5	6
190	R:R:L423	R:R:P392	3.28	No	No	0	8	9
191	R:R:C420	R:R:Y393	6.72	No	No	0	6	9
192	R:R:I421	R:R:Y393	3.63	Yes	No	0	4	9
193	R:R:F396	R:R:L413	6.09	No	No	0	4	7
194	R:R:C420	R:R:F396	4.19	No	No	0	6	4
195	R:R:G397	R:R:S400	3.71	No	No	0	8	2
196	R:R:L401	R:R:S400	3	No	No	0	7	2
197	R:R:L409	R:R:T403	8.84	No	Yes	0	3	2
198	R:R:L413	R:R:T403	2.95	No	Yes	0	7	2
199	R:R:D404	R:R:P405	4.83	No	No	0	4	4
200	R:R:D404	R:R:E406	3.9	No	No	0	4	1
201	R:R:D404	R:R:T407	8.67	No	No	0	4	7
202	R:R:P408	R:R:T407	5.25	No	No	0	4	7
203	R:R:T412	R:R:W416	4.85	No	Yes	0	6	7
204	R:R:V419	R:R:W416	6.13	No	Yes	0	5	7
205	R:R:C420	R:R:D417	3.11	No	No	0	6	8
206	R:R:H418	R:R:V419	6.92	No	No	0	4	5
207	R:R:A426	R:R:F430	4.16	No	No	0	8	7
208	R:R:N427	R:R:N431	9.54	No	No	0	9	9
209	R:R:N431	R:R:S428	2.98	No	No	1	9	9
210	R:R:F433	R:R:L437	4.87	No	No	0	6	7
211	R:R:K440	R:R:R443	4.95	No	No	0	7	9
212	R:R:K445	R:R:Q448	5.42	No	No	0	7	7
213	R:R:K445	R:R:S449	3.06	No	No	0	7	9
214	R:R:I450	R:R:R447	6.26	No	No	0	4	5
215	R:R:I421	R:R:L79	2.85	Yes	No	0	4	6
216	R:R:I395	R:R:L399	2.85	No	No	0	5	9
217	R:R:I450	R:R:L454	2.85	No	No	0	4	8
218	R:R:Q372	R:R:T375	2.83	No	No	0	5	7
219	R:R:K126	R:R:L122	2.82	No	No	0	6	7
220	R:R:M138	R:R:N135	2.8	No	No	0	6	5
221	R:R:P156	R:R:Y160	2.78	No	No	0	9	8
222	R:R:L66	R:R:L70	2.77	No	No	0	4	6
223	R:R:A150	R:R:F111	2.77	No	Yes	0	9	8
224	R:R:A436	R:R:F442	2.77	No	Yes	0	8	9
225	R:R:D441	R:R:K444	2.77	No	No	0	7	5
226	R:R:L69	R:R:N41	2.75	No	Yes	1	7	9
227	R:R:F107	R:R:V103	2.62	Yes	No	0	8	5
228	R:R:F376	R:R:V360	2.62	No	No	0	4	6
229	R:R:I59	R:R:R54	2.51	No	No	0	6	7
230	R:R:M363	R:R:R362	2.48	No	No	0	7	7
231	R:R:F151	R:R:L104	2.44	No	No	0	5	8
232	R:R:F442	R:R:L437	2.44	Yes	No	0	9	7
233	R:R:F61	R:R:N57	2.42	No	No	0	8	8
234	R:R:L84	R:R:Y90	2.34	No	Yes	0	8	7
235	R:R:L434	R:R:Y435	2.34	No	Yes	0	9	9
236	R:R:L25	R:R:W416	2.28	No	Yes	0	5	7
237	R:R:G40	R:R:P39	2.03	No	No	0	9	7
238	R:R:F396	R:R:W416	2	No	Yes	0	4	7
239	R:R:C143	R:R:G144	1.96	No	No	0	8	5
240	R:R:A335	R:R:P330	1.87	No	No	0	5	2
241	R:R:G410	R:R:T403	1.82	No	Yes	0	3	2
242	R:R:C145	R:R:S141	1.72	No	No	0	6	2
243	R:R:G37	R:R:L36	1.71	No	No	0	9	8
244	R:R:C130	R:R:V123	1.71	No	No	0	7	5
245	R:R:C140	R:R:V136	1.71	No	No	0	4	7
246	R:R:G42	R:R:N41	1.7	No	Yes	0	6	9
247	R:R:A48	R:R:T58	1.68	No	No	0	7	8
248	R:R:M414	R:R:P405	1.68	No	No	0	2	4
249	R:R:K126	R:R:P127	1.67	No	No	0	6	9
250	R:R:L38	R:R:P39	1.64	Yes	No	0	7	7
251	R:R:C140	R:R:I59	1.64	No	No	0	4	6
252	R:R:S371	R:R:S373	1.63	No	No	0	7	4
253	R:R:A426	R:R:I29	1.62	No	No	0	8	7
254	R:R:V342	R:R:V343	1.6	No	No	0	6	4
255	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
256	R:R:V381	R:R:V382	1.6	No	Yes	0	7	8
257	R:R:V381	R:R:V385	1.6	No	No	0	7	7
258	R:R:T339	R:R:V343	1.59	No	No	0	8	4
259	R:R:C71	R:R:N105	1.57	No	No	0	8	9
260	R:R:T403	R:R:T407	1.57	Yes	No	0	2	7
261	R:R:I353	R:R:S357	1.55	No	No	0	5	6
262	R:R:I24	R:R:V28	1.54	No	No	0	7	6
263	R:R:I338	R:R:V342	1.54	No	No	0	6	6
264	R:R:I351	R:R:V350	1.54	No	No	0	6	4
265	R:R:K370	R:R:S371	1.53	No	No	0	7	7
266	R:R:I359	R:R:T375	1.52	No	No	0	9	7
267	R:R:K374	R:R:V378	1.52	No	No	0	9	8
268	R:R:G86	R:R:R171	1.5	No	Yes	0	7	1
269	R:R:G366	R:R:R365	1.5	No	No	0	2	4
270	R:R:L45	R:R:T65	1.47	No	No	0	8	9
271	R:R:K374	R:R:K440	1.44	No	No	0	9	7
272	R:R:E20	R:R:V23	1.43	No	No	0	4	4
273	R:R:Q53	R:R:T55	1.42	No	No	0	6	9
274	R:R:I128	R:R:N132	1.42	No	No	0	7	8
275	R:R:A446	R:R:F442	1.39	No	Yes	0	8	9
276	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
277	R:R:R377	R:R:S373	1.32	No	No	0	5	4
278	R:R:F111	R:R:V149	1.31	Yes	No	0	8	4
279	R:R:F77	R:R:I98	1.26	No	Yes	0	8	8
280	R:R:I163	R:R:R92	1.25	No	No	0	6	1
281	R:R:S415	R:R:W416	1.24	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L38	4.6175	4	1	7
2	R:R:N41	5.30333	6	1	9
3	R:R:W46	5.5675	4	5	6
4	R:R:W60	5.11833	6	0	8
5	R:R:H63	7.2875	4	0	8
6	R:R:D68	7.02167	6	1	9
7	R:R:L75	5.965	4	4	9
8	R:R:W88	9.6525	4	2	9
9	R:R:Y90	6.0425	4	2	7
10	R:R:C95	4.9075	4	2	9
11	R:R:K96	7.435	4	6	8
12	R:R:I98	4.105	4	0	8
13	R:R:I102	4.5625	4	0	8
14	R:R:F107	7.1575	4	0	8
15	R:R:F111	4.6875	4	0	8
16	R:R:R161	8.125	4	0	8
17	R:R:H169	12.0675	4	3	3
18	R:R:R171	7.145	4	3	1
19	R:R:P348	3.5925	4	0	9
20	R:R:Y356	4.1275	4	0	9
21	R:R:V382	2.695	4	0	8
22	R:R:W390	9.135	4	0	9
23	R:R:T403	3.795	4	0	2
24	R:R:W416	3.65	6	0	7
25	R:R:I421	3.465	4	0	4
26	R:R:Y435	4.748	5	1	9
27	R:R:F442	4.466	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P22	R:R:W416	10.0345	5.4	No	Yes	0	4	7
2	R:R:G37	R:R:N41	11.1792	3.39	No	Yes	0	9	9
3	R:R:D68	R:R:N41	48.6276	6.73	Yes	Yes	1	9	9
4	R:R:D68	R:R:L64	66.4411	9.5	Yes	No	1	9	9
5	R:R:L64	R:R:Y435	66.6199	3.52	No	Yes	1	9	9
6	R:R:R120	R:R:Y435	94.5785	8.23	No	Yes	0	9	9
7	R:R:I116	R:R:R120	94.8551	7.52	No	No	0	9	9
8	R:R:I116	R:R:W60	95.187	7.05	No	Yes	0	9	8
9	R:R:I142	R:R:W60	100	4.7	No	Yes	0	5	8
10	R:R:I142	R:R:I146	99.217	2.94	No	No	0	5	8
11	R:R:F111	R:R:I146	99.0766	5.02	Yes	No	0	8	8
12	R:R:F107	R:R:F111	98.6042	9.65	Yes	Yes	0	8	8
13	R:R:F107	R:R:R340	94.8211	6.41	Yes	No	0	8	9
14	R:R:R340	R:R:Y393	94.5104	6.17	No	No	0	9	9
15	R:R:C420	R:R:Y393	32.512	6.72	No	No	0	6	9
16	R:R:C420	R:R:F396	30.929	4.19	No	No	0	6	4
17	R:R:F396	R:R:W416	18.5114	2	No	Yes	0	4	7
18	R:R:L69	R:R:N41	14.7538	2.75	No	Yes	1	7	9
19	R:R:L38	R:R:L69	12.3367	4.15	Yes	No	1	7	7
20	R:R:N41	R:R:T65	25.916	5.85	Yes	No	0	9	9
21	R:R:T65	R:R:V44	23.7116	7.93	No	No	0	9	9
22	R:R:F442	R:R:V44	22.5925	9.18	Yes	No	0	9	9
23	R:R:F442	R:R:V47	14.6474	6.55	Yes	No	0	9	8
24	R:R:G49	R:R:L62	10.1153	3.42	No	No	0	7	8
25	R:R:G49	R:R:R54	11.3537	3	No	No	0	7	7
26	R:R:I59	R:R:R54	12.5835	2.51	No	No	0	6	7
27	R:R:H63	R:R:I59	16.222	3.98	Yes	No	0	8	6
28	R:R:C143	R:R:H63	20.9541	14.74	No	Yes	0	8	8
29	R:R:C143	R:R:W60	23.2691	6.53	No	Yes	0	8	8
30	R:R:D68	R:R:N431	22.6393	10.77	Yes	No	1	9	9
31	R:R:I421	R:R:Y393	81.2843	3.63	Yes	No	0	4	9
32	R:R:I421	R:R:S78	79.697	3.1	Yes	No	0	4	8
33	R:R:I102	R:R:S78	79.1778	9.29	Yes	No	0	8	8
34	R:R:I102	R:R:I98	76.6926	2.94	Yes	Yes	0	8	8
35	R:R:I98	R:R:P99	36.3122	5.08	Yes	No	0	8	8
36	R:R:H81	R:R:P99	35.4696	6.1	No	No	0	7	8
37	R:R:I98	R:R:L94	39.1166	7.14	Yes	No	0	8	8
38	R:R:L94	R:R:W88	35.393	9.11	No	Yes	2	8	9
39	R:R:C95	R:R:H81	34.6142	2.95	Yes	No	2	9	7
40	R:R:C95	R:R:W88	35.0738	5.22	Yes	Yes	2	9	9
41	R:R:C95	R:R:R161	65.9858	4.18	Yes	Yes	0	9	8
42	R:R:G173	R:R:R161	27.1586	3	No	Yes	0	1	8
43	R:R:F164	R:R:G173	25.1202	3.01	No	No	0	3	1
44	R:R:F164	R:R:R171	18.954	14.97	No	Yes	0	3	1
45	R:R:K96	R:R:R161	37.2229	3.71	Yes	Yes	0	8	8
46	R:R:F158	R:R:K96	25.0692	12.41	No	Yes	6	8	8
47	R:R:C154	R:R:S100	21.0179	5.16	No	No	0	8	8
48	R:R:F158	R:R:S100	23.0733	5.28	No	No	0	8	8
49	R:R:C154	R:R:L104	18.954	4.76	No	No	0	8	8
50	R:R:F107	R:R:M153	15.0304	9.95	Yes	No	0	8	8
51	R:R:N427	R:R:N431	22.6563	9.54	No	No	0	9	9
52	R:R:N427	R:R:W390	17.9965	12.43	No	Yes	0	9	9
53	R:R:V110	R:R:W390	20.3243	4.9	No	Yes	0	9	9
54	R:R:P348	R:R:V110	18.3284	3.53	Yes	No	0	9	9
55	R:R:V382	R:R:Y435	34.3291	3.79	Yes	Yes	0	8	9
56	R:R:V382	R:R:Y356	28.0693	3.79	Yes	Yes	0	8	9
57	R:R:M352	R:R:Y356	17.6901	3.59	No	Yes	0	8	9
58	R:R:F386	R:R:M352	14.6517	8.71	No	No	0	9	8
59	R:R:F386	R:R:W390	14.0942	16.04	No	Yes	0	9	9
60	R:R:I142	R:R:M138	27.6948	4.37	No	No	0	5	6
61	R:R:M138	R:R:W129	24.3074	5.82	No	No	0	6	6
62	R:R:L122	R:R:W129	18.6008	3.42	No	No	0	7	6
63	R:R:K126	R:R:L122	17.4135	2.82	No	No	0	6	7
64	R:R:F125	R:R:K126	15.0134	9.93	No	No	0	6	6
65	R:R:F125	R:R:F358	13.7963	6.43	No	No	0	6	6
66	R:R:F358	R:R:R362	12.6729	13.9	No	No	0	6	7
67	R:R:F151	R:R:L104	16.8816	2.44	No	No	0	5	8
68	R:R:F151	R:R:I155	14.8006	5.02	No	No	0	5	5
69	R:R:M153	R:R:V343	13.8134	3.04	No	No	0	8	4
70	R:R:I155	R:R:P156	12.7112	3.39	No	No	0	5	9
71	R:R:P156	R:R:Y160	10.6132	2.78	No	No	0	9	8
72	R:R:V342	R:R:V343	11.3622	1.6	No	No	0	6	4
73	R:R:M363	R:R:R362	10.2089	2.48	No	No	0	7	7
74	R:R:F396	R:R:L413	12.5835	6.09	No	No	0	4	7
75	R:R:L413	R:R:T403	11.4473	2.95	No	Yes	0	7	2

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HK3_nogp

PDB Summary
PDB	8HK3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	268
Number of Links	281
Number of Hubs	27
Number of Links mediated by Hubs	108
Number of Communities	6
Number of Nodes involved in Communities	29
Number of Links involved in Communities	34

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	43547
Length Of Smallest Path	3
Average Path Length	18.2439
Length of Longest Path	40
Minimum Path Strength	1.37
Average Path Strength	5.72445
Maximum Path Strength	14.47
Minimum Path Correlation	0.7
Average Path Correlation	0.92673
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	42.2975
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.458
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8HK3_nogp_Chain_R W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y K F P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HK3_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.