psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L30	7.61	Yes	No	0	0	6
2	L:L:?1	R:R:S78	19.61	Yes	No	0	0	8
3	L:L:?1	R:R:H81	15.91	Yes	No	1	0	7
4	L:L:?1	R:R:L82	5.71	Yes	No	0	0	7
5	L:L:?1	R:R:W88	3.92	Yes	Yes	1	0	9
6	L:L:?1	R:R:I98	3.93	Yes	No	1	0	8
7	L:L:?1	R:R:I102	7.85	Yes	No	0	0	8
8	L:L:?1	R:R:V103	4.1	Yes	No	0	0	5
9	L:L:?1	R:R:R161	3.34	Yes	Yes	1	0	8
10	L:L:?1	R:R:Y174	9.67	Yes	Yes	1	0	7
11	L:L:?1	R:R:R340	5.85	Yes	No	1	0	9
12	L:L:?1	R:R:Y393	31.43	Yes	Yes	1	0	9
13	L:L:?1	R:R:G397	3.53	Yes	No	0	0	8
14	L:L:?1	R:R:D417	12.13	Yes	No	1	0	8
15	L:L:?1	R:R:I421	13.74	Yes	No	1	0	4
16	R:R:I24	R:R:N19	8.5	No	No	0	7	1
17	R:R:E20	R:R:P21	3.14	Yes	No	3	4	6
18	R:R:E20	R:R:P22	11	Yes	No	3	4	4
19	R:R:E20	R:R:V23	7.13	Yes	No	0	4	4
20	R:R:E20	R:R:S415	5.75	Yes	No	0	4	5
21	R:R:P21	R:R:P22	5.84	No	No	3	6	4
22	R:R:M27	R:R:V23	3.04	No	No	0	6	4
23	R:R:I29	R:R:L25	5.71	No	No	0	7	5
24	R:R:L25	R:R:V419	4.47	No	No	0	5	5
25	R:R:S26	R:R:V419	3.23	No	No	0	8	5
26	R:R:L32	R:R:V28	2.98	No	No	0	6	6
27	R:R:A422	R:R:I29	3.25	No	No	0	8	7
28	R:R:A422	R:R:L30	3.15	No	No	0	8	6
29	R:R:F34	R:R:L35	3.65	Yes	No	0	7	6
30	R:R:F34	R:R:L38	9.74	Yes	No	0	7	7
31	R:R:F34	R:R:P76	5.78	Yes	No	0	7	9
32	R:R:C429	R:R:G37	3.92	No	No	0	9	9
33	R:R:L38	R:R:P39	8.21	No	No	0	7	7
34	R:R:D68	R:R:N41	8.08	Yes	No	1	9	9
35	R:R:N41	R:R:P432	14.66	No	No	1	9	9
36	R:R:L43	R:R:V47	2.98	No	No	0	8	8
37	R:R:I450	R:R:L43	4.28	No	No	0	4	8
38	R:R:T65	R:R:V44	3.17	No	No	0	9	9
39	R:R:L437	R:R:V44	2.98	No	No	0	7	9
40	R:R:F442	R:R:V44	6.55	Yes	No	0	9	9
41	R:R:L45	R:R:T65	10.32	No	No	0	8	9
42	R:R:L50	R:R:W46	7.97	No	No	0	4	6
43	R:R:K51	R:R:W46	4.64	No	No	4	9	6
44	R:R:S449	R:R:W46	3.71	No	No	4	9	6
45	R:R:F442	R:R:V47	3.93	Yes	No	0	9	8
46	R:R:S449	R:R:V47	4.85	No	No	0	9	8
47	R:R:A48	R:R:L62	3.15	No	No	0	7	8
48	R:R:G49	R:R:L62	3.42	No	No	0	7	8
49	R:R:K51	R:R:S449	6.12	No	No	4	9	9
50	R:R:M52	R:R:Q53	4.08	Yes	No	0	9	6
51	R:R:M52	R:R:T58	3.01	Yes	No	0	9	8
52	R:R:F442	R:R:M52	6.22	Yes	Yes	0	9	9
53	R:R:I59	R:R:R54	3.76	No	No	0	6	7
54	R:R:T55	R:R:T58	7.85	No	No	0	9	8
55	R:R:V56	R:R:W60	3.68	No	Yes	0	8	8
56	R:R:R134	R:R:V56	15.69	Yes	No	0	9	8
57	R:R:A139	R:R:V56	3.39	No	No	0	7	8
58	R:R:N57	R:R:R134	6.03	No	Yes	0	8	9
59	R:R:L62	R:R:T58	2.95	No	No	0	8	8
60	R:R:I59	R:R:V136	3.07	No	No	0	6	7
61	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
62	R:R:I116	R:R:W60	7.05	No	Yes	0	9	8
63	R:R:I142	R:R:W60	3.52	No	Yes	0	5	8
64	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
65	R:R:A436	R:R:F61	4.16	No	No	0	8	8
66	R:R:H63	R:R:L112	3.86	Yes	No	0	8	9
67	R:R:C143	R:R:H63	14.74	No	Yes	0	8	8
68	R:R:H63	R:R:W147	6.35	Yes	Yes	0	8	9
69	R:R:D68	R:R:L64	8.14	Yes	Yes	1	9	9
70	R:R:L64	R:R:S109	3	Yes	Yes	1	9	9
71	R:R:L113	R:R:L64	4.15	No	Yes	1	8	9
72	R:R:L64	R:R:N431	5.49	Yes	Yes	1	9	9
73	R:R:D68	R:R:S109	2.94	Yes	Yes	1	9	9
74	R:R:D68	R:R:S428	7.36	Yes	No	0	9	9
75	R:R:D68	R:R:P432	3.22	Yes	No	1	9	9
76	R:R:L69	R:R:L73	5.54	No	No	0	7	8
77	R:R:L70	R:R:N105	8.24	No	No	0	6	9
78	R:R:C71	R:R:S428	6.89	No	No	0	8	9
79	R:R:I102	R:R:S74	6.19	No	No	0	8	9
80	R:R:L75	R:R:S425	3	No	No	0	9	8
81	R:R:G86	R:R:H81	3.18	No	No	0	7	7
82	R:R:H81	R:R:W88	8.46	No	Yes	1	7	9
83	R:R:W88	R:R:Y90	20.26	Yes	No	0	9	7
84	R:R:L94	R:R:W88	3.42	No	Yes	0	8	9
85	R:R:I98	R:R:W88	4.7	No	Yes	1	8	9
86	R:R:P89	R:R:Y90	5.56	No	No	0	8	7
87	R:R:K96	R:R:R92	17.33	No	No	0	8	1
88	R:R:E162	R:R:R92	13.96	No	No	0	5	1
89	R:R:F93	R:R:L97	3.65	No	No	0	4	6
90	R:R:C172	R:R:C95	7.28	No	No	0	8	9
91	R:R:F158	R:R:K96	4.96	No	No	0	8	8
92	R:R:I101	R:R:L97	7.14	No	No	0	5	6
93	R:R:I98	R:R:P99	5.08	No	No	0	8	8
94	R:R:P99	R:R:R161	10.09	No	Yes	0	8	8
95	R:R:I101	R:R:N105	4.25	No	No	0	5	9
96	R:R:I102	R:R:M106	4.37	No	No	0	8	9
97	R:R:C154	R:R:V103	3.42	No	No	0	8	5
98	R:R:V103	R:R:V157	6.41	No	No	0	5	9
99	R:R:L104	R:R:W147	3.42	No	Yes	0	8	9
100	R:R:C154	R:R:L104	4.76	No	No	0	8	8
101	R:R:M106	R:R:W390	5.82	No	Yes	0	9	9
102	R:R:M106	R:R:S425	3.07	No	No	0	9	8
103	R:R:F107	R:R:F111	4.29	No	Yes	0	8	8
104	R:R:F107	R:R:M153	6.22	No	No	0	8	8
105	R:R:F107	R:R:R340	7.48	No	No	0	8	9
106	R:R:A108	R:R:W147	6.48	No	Yes	0	9	9
107	R:R:N431	R:R:S109	2.98	Yes	Yes	1	9	9
108	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
109	R:R:V110	R:R:W390	7.36	No	Yes	0	9	9
110	R:R:F111	R:R:I146	7.54	Yes	No	0	8	8
111	R:R:F111	R:R:V149	3.93	Yes	No	0	8	4
112	R:R:I146	R:R:L112	4.28	No	No	0	8	9
113	R:R:L113	R:R:N431	12.36	No	Yes	1	8	9
114	R:R:L113	R:R:Y435	14.07	No	Yes	1	8	9
115	R:R:P348	R:R:T114	6.99	Yes	No	0	9	8
116	R:R:I351	R:R:T114	4.56	No	No	0	6	8
117	R:R:I116	R:R:R120	6.26	No	No	1	9	9
118	R:R:I116	R:R:Y435	3.63	No	Yes	1	9	9
119	R:R:M352	R:R:S117	6.13	No	No	1	8	9
120	R:R:C355	R:R:S117	3.44	No	No	0	9	9
121	R:R:S117	R:R:Y356	3.82	No	Yes	1	9	9
122	R:R:I351	R:R:L118	4.28	No	No	0	6	8
123	R:R:D119	R:R:V123	4.38	No	No	2	9	5
124	R:R:D119	R:R:R134	15.48	No	Yes	2	9	9
125	R:R:R120	R:R:Y435	6.17	No	Yes	1	9	9
126	R:R:C121	R:R:C355	7.28	No	No	0	9	9
127	R:R:C121	R:R:F358	5.59	No	No	0	9	6
128	R:R:C130	R:R:L122	4.76	No	No	0	7	7
129	R:R:C130	R:R:V123	5.12	No	No	2	7	5
130	R:R:R134	R:R:V123	3.92	Yes	No	2	9	5
131	R:R:F125	R:R:K126	11.17	No	No	0	6	6
132	R:R:F125	R:R:F358	8.57	No	No	0	6	6
133	R:R:H133	R:R:W129	12.7	No	No	0	8	6
134	R:R:M138	R:R:W129	3.49	No	No	0	6	6
135	R:R:C130	R:R:R134	4.18	No	Yes	2	7	9
136	R:R:H133	R:R:N132	3.83	No	No	0	8	8
137	R:R:G137	R:R:N135	3.39	No	No	0	5	5
138	R:R:F151	R:R:I155	3.77	No	No	0	5	5
139	R:R:M153	R:R:V343	3.04	No	No	0	8	4
140	R:R:I155	R:R:P156	3.39	No	No	0	5	9
141	R:R:I336	R:R:P156	5.08	No	No	0	7	9
142	R:R:V157	R:R:Y174	3.79	No	Yes	0	9	7
143	R:R:V159	R:R:Y160	6.31	No	No	0	4	8
144	R:R:I336	R:R:Y160	4.84	No	No	0	7	8
145	R:R:C172	R:R:R161	5.57	No	Yes	0	8	8
146	R:R:G173	R:R:R161	6	No	Yes	0	1	8
147	R:R:R161	R:R:Y174	13.38	Yes	Yes	1	8	7
148	R:R:L401	R:R:V334	2.98	Yes	No	0	7	4
149	R:R:L401	R:R:T337	5.9	Yes	No	0	7	7
150	R:R:R340	R:R:Y393	4.12	No	Yes	1	9	9
151	R:R:F345	R:R:L341	4.87	Yes	Yes	1	9	6
152	R:R:L341	R:R:L346	8.3	Yes	No	1	6	8
153	R:R:H394	R:R:L341	3.86	Yes	Yes	1	9	6
154	R:R:L347	R:R:V342	2.98	No	No	0	7	6
155	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
156	R:R:F345	R:R:L346	3.65	Yes	No	1	9	8
157	R:R:F345	R:R:T391	6.49	Yes	Yes	0	9	6
158	R:R:F345	R:R:H394	21.5	Yes	Yes	1	9	9
159	R:R:M352	R:R:Y356	4.79	No	Yes	1	8	9
160	R:R:F386	R:R:M352	3.73	No	No	0	9	8
161	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	9
162	R:R:V382	R:R:Y356	5.05	No	Yes	1	8	9
163	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
164	R:R:Y356	R:R:Y435	2.98	Yes	Yes	1	9	9
165	R:R:F358	R:R:R362	6.41	No	No	0	6	7
166	R:R:Q364	R:R:V360	5.73	No	No	0	5	6
167	R:R:F376	R:R:V360	9.18	No	No	0	4	6
168	R:R:F361	R:R:R365	4.28	No	No	0	4	4
169	R:R:F368	R:R:R367	12.83	No	No	0	5	6
170	R:R:Q372	R:R:T375	5.67	No	No	0	5	7
171	R:R:F376	R:R:V380	7.87	No	No	0	4	3
172	R:R:V382	R:R:Y435	3.79	No	Yes	1	8	9
173	R:R:L387	R:R:V383	2.98	No	No	0	6	8
174	R:R:F430	R:R:V385	3.93	No	No	0	7	7
175	R:R:L434	R:R:V385	4.47	No	No	0	9	7
176	R:R:F386	R:R:W390	14.03	No	Yes	0	9	9
177	R:R:L387	R:R:T391	2.95	No	Yes	0	6	6
178	R:R:C389	R:R:W390	3.92	No	Yes	1	9	9
179	R:R:C389	R:R:N427	9.45	No	No	1	9	9
180	R:R:H394	R:R:W390	3.17	Yes	Yes	1	9	9
181	R:R:N427	R:R:W390	14.69	No	Yes	1	9	9
182	R:R:P392	R:R:T391	5.25	No	Yes	0	9	6
183	R:R:I395	R:R:T391	3.04	No	Yes	0	5	6
184	R:R:C420	R:R:P392	3.77	No	No	0	6	9
185	R:R:H394	R:R:Y393	6.53	Yes	Yes	1	9	9
186	R:R:I421	R:R:Y393	6.04	No	Yes	1	4	9
187	R:R:F396	R:R:L413	6.09	No	No	0	4	7
188	R:R:C420	R:R:F396	9.78	No	No	0	6	4
189	R:R:L401	R:R:S400	6.01	Yes	No	0	7	2
190	R:R:L409	R:R:T403	5.9	No	No	0	3	2
191	R:R:L413	R:R:T403	4.42	No	No	0	7	2
192	R:R:D404	R:R:P405	6.44	No	No	0	4	4
193	R:R:D404	R:R:E406	9.09	No	No	0	4	1
194	R:R:D404	R:R:T407	7.23	No	No	0	4	7
195	R:R:L409	R:R:T412	2.95	No	No	0	3	6
196	R:R:G410	R:R:L413	5.13	No	No	0	3	7
197	R:R:V419	R:R:W416	7.36	No	No	0	5	7
198	R:R:D417	R:R:I421	8.4	No	No	1	8	4
199	R:R:A426	R:R:F430	4.16	No	No	0	8	7
200	R:R:N427	R:R:N431	12.26	No	Yes	1	9	9
201	R:R:N431	R:R:Y435	3.49	Yes	Yes	1	9	9
202	R:R:F433	R:R:P432	2.89	No	No	0	6	9
203	R:R:F433	R:R:L437	4.87	No	No	0	6	7
204	R:R:K444	R:R:K445	5.75	No	No	0	5	7
205	R:R:K444	R:R:Q448	9.49	No	No	0	5	7
206	R:R:K445	R:R:M52	2.88	No	Yes	0	7	9
207	R:R:I395	R:R:L399	2.85	No	No	0	5	9
208	R:R:L82	R:R:M27	2.83	No	No	0	7	6
209	R:R:I128	R:R:N132	2.83	No	No	0	7	8
210	R:R:H418	R:R:S26	2.79	No	No	0	4	8
211	R:R:C389	R:R:F430	2.79	No	No	0	9	7
212	R:R:L30	R:R:L79	2.77	No	No	0	6	6
213	R:R:A150	R:R:F111	2.77	No	Yes	0	9	8
214	R:R:L333	R:R:L401	2.77	No	Yes	0	3	7
215	R:R:A436	R:R:F442	2.77	No	Yes	0	8	9
216	R:R:K370	R:R:Q372	2.71	No	No	0	7	5
217	R:R:H63	R:R:I59	2.65	Yes	No	0	8	6
218	R:R:F77	R:R:S74	2.64	No	No	0	8	9
219	R:R:N170	R:R:Q87	2.64	No	No	0	4	6
220	R:R:F158	R:R:S100	2.64	No	No	0	8	8
221	R:R:N132	R:R:Q131	2.64	No	No	0	8	9
222	R:R:R362	R:R:V124	2.62	No	No	0	7	9
223	R:R:A424	R:R:W390	2.59	No	Yes	0	9	9
224	R:R:I163	R:R:R92	2.51	No	No	0	6	1
225	R:R:M138	R:R:R134	2.48	No	Yes	0	6	9
226	R:R:F34	R:R:L75	2.44	Yes	No	0	7	9
227	R:R:F93	R:R:L94	2.44	No	No	0	4	8
228	R:R:G40	R:R:P39	2.03	No	No	0	9	7
229	R:R:Y160	R:R:Y174	1.99	No	Yes	0	8	7
230	R:R:C72	R:R:G37	1.96	No	No	0	8	9
231	R:R:A369	R:R:G366	1.95	No	No	0	5	2
232	R:R:G410	R:R:T407	1.82	No	No	0	3	7
233	R:R:P408	R:R:T407	1.75	No	No	0	4	7
234	R:R:C72	R:R:S428	1.72	No	No	0	8	9
235	R:R:A67	R:R:S109	1.71	No	Yes	0	9	9
236	R:R:C140	R:R:V136	1.71	No	No	0	4	7
237	R:R:C145	R:R:V149	1.71	No	No	0	6	4
238	R:R:C429	R:R:T33	1.69	No	No	0	9	8
239	R:R:M414	R:R:P405	1.68	No	No	0	2	4
240	R:R:K126	R:R:P127	1.67	No	No	0	6	9
241	R:R:L84	R:R:P89	1.64	No	No	0	8	8
242	R:R:C172	R:R:I163	1.64	No	No	0	8	6
243	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
244	R:R:L423	R:R:P392	1.64	No	No	0	8	9
245	R:R:S31	R:R:V28	1.62	No	No	0	7	6
246	R:R:S349	R:R:V350	1.62	No	No	0	4	4
247	R:R:V148	R:R:V152	1.6	No	No	0	5	5
248	R:R:V378	R:R:V382	1.6	No	No	0	8	8
249	R:R:V381	R:R:V385	1.6	No	No	0	7	7
250	R:R:C429	R:R:L36	1.59	No	No	0	9	8
251	R:R:T339	R:R:V343	1.59	No	No	0	8	4
252	R:R:I353	R:R:S357	1.55	No	No	0	5	6
253	R:R:I24	R:R:V28	1.54	No	No	0	7	6
254	R:R:I359	R:R:V124	1.54	No	No	0	9	9
255	R:R:I338	R:R:V334	1.54	No	No	0	6	4
256	R:R:I338	R:R:V342	1.54	No	No	0	6	6
257	R:R:I353	R:R:V383	1.54	No	No	0	5	8
258	R:R:M363	R:R:V124	1.52	No	No	0	7	9
259	R:R:M153	R:R:V152	1.52	No	No	0	8	5
260	R:R:I359	R:R:T375	1.52	No	No	0	9	7
261	R:R:K374	R:R:V378	1.52	No	No	0	9	8
262	R:R:G366	R:R:R365	1.5	No	No	0	2	4
263	R:R:L341	R:R:V398	1.49	Yes	No	0	6	7
264	R:R:L438	R:R:V378	1.49	No	No	0	7	8
265	R:R:L423	R:R:V388	1.49	No	No	0	8	6
266	R:R:G91	R:R:Y90	1.45	No	No	0	9	7
267	R:R:K440	R:R:K444	1.44	No	No	0	7	5
268	R:R:I163	R:R:N170	1.42	No	No	0	6	4
269	R:R:G144	R:R:W147	1.41	No	Yes	0	5	9
270	R:R:D441	R:R:M52	1.39	No	Yes	0	7	9
271	R:R:L38	R:R:L73	1.38	No	No	0	7	8
272	R:R:L45	R:R:L66	1.38	No	No	0	8	4
273	R:R:L66	R:R:L70	1.38	No	No	0	4	6
274	R:R:E162	R:R:K175	1.35	No	No	0	5	5
275	R:R:F386	R:R:S349	1.32	No	No	0	9	4
276	R:R:R377	R:R:V381	1.31	No	No	0	5	7
277	R:R:M414	R:R:R171	1.24	No	No	0	2	1
278	R:R:L438	R:R:R443	1.21	No	No	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.88867	15	1	0
2	R:R:E20	6.755	4	3	4
3	R:R:F34	5.4025	4	0	7
4	R:R:M52	3.516	5	0	9
5	R:R:W60	4.412	5	0	8
6	R:R:H63	6.9	4	0	8
7	R:R:L64	5.195	4	1	9
8	R:R:D68	5.948	5	1	9
9	R:R:W88	8.152	5	1	9
10	R:R:S109	2.6575	4	1	9
11	R:R:F111	4.6325	4	0	8
12	R:R:R134	7.96333	6	2	9
13	R:R:W147	4.415	4	0	9
14	R:R:R161	7.676	5	1	8
15	R:R:Y174	7.2075	4	1	7
16	R:R:L341	4.63	4	1	6
17	R:R:F345	9.1275	4	1	9
18	R:R:P348	4.055	4	0	9
19	R:R:Y356	4.295	6	1	9
20	R:R:W390	7.36857	7	1	9
21	R:R:T391	4.4325	4	0	6
22	R:R:Y393	12.03	4	1	9
23	R:R:H394	8.765	4	1	9
24	R:R:L401	4.415	4	0	7
25	R:R:N431	7.316	5	1	9
26	R:R:Y435	5.68833	6	1	9
27	R:R:F442	4.8675	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L82	17.5103	5.71	Yes	No	0	0	7
2	R:R:L82	R:R:M27	15.1862	2.83	No	No	0	7	6
3	R:R:M27	R:R:V23	12.8559	3.04	No	No	0	6	4
4	R:R:E20	R:R:V23	10.258	7.13	Yes	No	0	4	4
5	L:L:?1	R:R:L30	23.1139	7.61	Yes	No	0	0	6
6	R:R:A422	R:R:L30	18.2648	3.15	No	No	0	8	6
7	R:R:A422	R:R:I29	15.6912	3.25	No	No	0	8	7
8	R:R:I29	R:R:L25	13.1054	5.71	No	No	0	7	5
9	R:R:L25	R:R:V419	10.5074	4.47	No	No	0	5	5
10	L:L:?1	R:R:I102	50.724	7.85	Yes	No	0	0	8
11	R:R:I102	R:R:M106	52.2451	4.37	No	No	0	8	9
12	R:R:M106	R:R:S425	16.622	3.07	No	No	0	9	8
13	R:R:L75	R:R:S425	15.0036	3	No	No	0	9	8
14	R:R:F34	R:R:L75	13.4765	2.44	Yes	No	0	7	9
15	R:R:M106	R:R:W390	58.5666	5.82	No	Yes	0	9	9
16	R:R:N427	R:R:W390	92.1818	14.69	No	Yes	1	9	9
17	R:R:N427	R:R:N431	96.8849	12.26	No	Yes	1	9	9
18	R:R:L64	R:R:N431	58.5787	5.49	Yes	Yes	1	9	9
19	R:R:D68	R:R:L64	75.4563	8.14	Yes	Yes	1	9	9
20	R:R:D68	R:R:S428	28.3159	7.36	Yes	No	0	9	9
21	R:R:C72	R:R:S428	20.2847	1.72	No	No	0	8	9
22	R:R:C72	R:R:G37	16.2509	1.96	No	No	0	8	9
23	R:R:C429	R:R:G37	12.2049	3.92	No	No	0	9	9
24	L:L:?1	R:R:Y393	55.8895	31.43	Yes	Yes	1	0	9
25	R:R:H394	R:R:Y393	69.9623	6.53	Yes	Yes	1	9	9
26	R:R:H394	R:R:W390	75.0548	3.17	Yes	Yes	1	9	9
27	R:R:N431	R:R:S109	60.2762	2.98	Yes	Yes	1	9	9
28	R:R:D68	R:R:S109	57.4045	2.94	Yes	Yes	1	9	9
29	R:R:D68	R:R:P432	100	3.22	Yes	No	1	9	9
30	L:L:?1	R:R:W88	26.4663	3.92	Yes	Yes	1	0	9
31	R:R:L94	R:R:W88	19.2808	3.42	No	Yes	0	8	9
32	R:R:F93	R:R:L94	17.6138	2.44	No	No	0	4	8
33	R:R:F93	R:R:L97	15.965	3.65	No	No	0	4	6
34	R:R:I101	R:R:L97	14.4074	7.14	No	No	0	5	6
35	R:R:I101	R:R:N105	13.0506	4.25	No	No	0	5	9
36	R:R:L70	R:R:N105	11.8946	8.24	No	No	0	6	9
37	R:R:L66	R:R:L70	11.6938	1.38	No	No	0	4	6
38	R:R:L45	R:R:L66	12.1562	1.38	No	No	0	8	4
39	R:R:L45	R:R:T65	13.799	10.32	No	No	0	8	9
40	R:R:T65	R:R:V44	15.7885	3.17	No	No	0	9	9
41	R:R:F442	R:R:V44	86.7182	6.55	Yes	No	0	9	9
42	R:R:F442	R:R:V47	27.8292	3.93	Yes	No	0	9	8
43	R:R:F433	R:R:P432	96.5381	2.89	No	No	0	6	9
44	R:R:F433	R:R:L437	92.8936	4.87	No	No	0	6	7
45	R:R:L437	R:R:V44	89.2918	2.98	No	No	0	7	9
46	R:R:S449	R:R:V47	16.3239	4.85	No	No	0	9	8
47	R:R:F442	R:R:M52	48.3999	6.22	Yes	Yes	0	9	9
48	R:R:M52	R:R:T58	20.376	3.01	Yes	No	0	9	8
49	R:R:L62	R:R:T58	12.2597	2.95	No	No	0	8	8
50	L:L:?1	R:R:V103	18.7333	4.1	Yes	No	0	0	5
51	R:R:C154	R:R:V103	15.8554	3.42	No	No	0	8	5
52	R:R:C154	R:R:L104	13.7503	4.76	No	No	0	8	8
53	R:R:L104	R:R:W147	13.726	3.42	No	Yes	0	8	9
54	R:R:H63	R:R:W147	14.1823	6.35	Yes	Yes	0	8	9
55	R:R:C143	R:R:H63	21.0635	14.74	No	Yes	0	8	8
56	R:R:C143	R:R:W60	21.9031	3.92	No	Yes	0	8	8
57	R:R:V56	R:R:W60	26.1317	3.68	No	Yes	0	8	8
58	R:R:R134	R:R:V56	22.4203	15.69	Yes	No	0	9	8
59	R:R:F107	R:R:R340	16.3178	7.48	No	No	0	8	9
60	L:L:?1	R:R:R161	34.0411	3.34	Yes	Yes	1	0	8
61	R:R:C172	R:R:R161	28.3706	5.57	No	Yes	0	8	8
62	R:R:C172	R:R:I163	23.3208	1.64	No	No	0	8	6
63	R:R:I163	R:R:R92	15.6547	2.51	No	No	0	6	1
64	L:L:?1	R:R:Y174	19.3721	9.67	Yes	Yes	1	0	7
65	R:R:V110	R:R:W390	28.468	7.36	No	Yes	0	9	9
66	R:R:P348	R:R:V110	26.4967	3.53	Yes	No	0	9	9
67	R:R:N431	R:R:Y435	51.7644	3.49	Yes	Yes	1	9	9
68	R:R:F386	R:R:W390	28.614	14.03	No	Yes	0	9	9
69	R:R:F386	R:R:M352	24.2881	3.73	No	No	0	9	8
70	R:R:M352	R:R:S117	15.3018	6.13	No	No	1	8	9
71	R:R:C355	R:R:S117	29.1494	3.44	No	No	0	9	9
72	R:R:C121	R:R:C355	26.9591	7.28	No	No	0	9	9
73	R:R:C121	R:R:F358	24.7445	5.59	No	No	0	9	6
74	R:R:M138	R:R:R134	11.6513	2.48	No	Yes	0	6	9
75	R:R:Y160	R:R:Y174	16.4091	1.99	No	Yes	0	8	7
76	R:R:I336	R:R:Y160	10.8907	4.84	No	No	0	7	8
77	R:R:L347	R:R:P348	16.4578	1.64	No	Yes	0	7	9
78	R:R:L347	R:R:V342	14.4135	2.98	No	No	0	7	6
79	R:R:I338	R:R:V342	12.357	1.54	No	No	0	6	6
80	R:R:I338	R:R:V334	10.2884	1.54	No	No	0	6	4
81	R:R:F345	R:R:H394	29.91	21.5	Yes	Yes	1	9	9
82	R:R:F345	R:R:T391	28.0239	6.49	Yes	Yes	0	9	6
83	R:R:L387	R:R:T391	23.1626	2.95	No	Yes	0	6	6
84	R:R:L387	R:R:V383	23.3816	2.98	No	No	0	6	8
85	R:R:F358	R:R:R362	15.8128	6.41	No	No	0	6	7
86	R:R:R362	R:R:V124	13.5374	2.62	No	No	0	7	9
87	R:R:C389	R:R:F430	12.6612	2.79	No	No	0	9	7
88	R:R:P392	R:R:T391	39.0302	5.25	No	Yes	0	9	6
89	R:R:C420	R:R:P392	32.3315	3.77	No	No	0	6	9
90	R:R:C420	R:R:F396	30.0621	9.78	No	No	0	6	4
91	R:R:F396	R:R:L413	27.7866	6.09	No	No	0	4	7
92	R:R:G410	R:R:L413	18.788	5.13	No	No	0	3	7
93	R:R:G410	R:R:T407	16.4578	1.82	No	No	0	3	7
94	R:R:D404	R:R:T407	11.7608	7.23	No	No	0	4	7
95	R:R:K445	R:R:M52	16.3178	2.88	No	Yes	0	7	9
96	R:R:K444	R:R:K445	12.2597	5.75	No	No	0	5	7
97	R:R:V378	R:R:V382	12.8742	1.6	No	No	0	8	8
98	R:R:I116	R:R:Y435	37.0285	3.63	No	Yes	1	9	9
99	R:R:I116	R:R:W60	35.6291	7.05	No	Yes	0	9	8
100	R:R:V383	R:R:Y356	25.578	3.79	No	Yes	0	8	9
101	R:R:R340	R:R:Y393	11.5113	4.12	No	Yes	1	9	9
102	R:R:L113	R:R:L64	18.7941	4.15	No	Yes	1	8	9
103	R:R:L113	R:R:Y435	19.0253	14.07	No	Yes	1	8	9
104	R:R:Y356	R:R:Y435	37.9776	2.98	Yes	Yes	1	9	9
105	R:R:S117	R:R:Y356	16.0197	3.82	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L30	7.61	1	Yes	No	0	6	0	1
L:L:?1	R:R:S78	19.61	1	Yes	No	0	8	0	1
L:L:?1	R:R:H81	15.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:L82	5.71	1	Yes	No	0	7	0	1
L:L:?1	R:R:W88	3.92	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I98	3.93	1	Yes	No	0	8	0	1
L:L:?1	R:R:I102	7.85	1	Yes	No	0	8	0	1
L:L:?1	R:R:V103	4.1	1	Yes	No	0	5	0	1
L:L:?1	R:R:R161	3.34	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y174	9.67	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R340	5.85	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y393	31.43	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G397	3.53	1	Yes	No	0	8	0	1
L:L:?1	R:R:D417	12.13	1	Yes	No	0	8	0	1
L:L:?1	R:R:I421	13.74	1	Yes	No	0	4	0	1
R:R:A422	R:R:L30	3.15	0	No	No	8	6	2	1
R:R:I102	R:R:S74	6.19	0	No	No	8	9	1	2
R:R:G86	R:R:H81	3.18	0	No	No	7	7	2	1
R:R:H81	R:R:W88	8.46	1	No	Yes	7	9	1	1
R:R:W88	R:R:Y90	20.26	1	Yes	No	9	7	1	2
R:R:L94	R:R:W88	3.42	0	No	Yes	8	9	2	1
R:R:I98	R:R:W88	4.7	1	No	Yes	8	9	1	1
R:R:I98	R:R:P99	5.08	1	No	No	8	8	1	2
R:R:P99	R:R:R161	10.09	0	No	Yes	8	8	2	1
R:R:I102	R:R:M106	4.37	0	No	No	8	9	1	2
R:R:C154	R:R:V103	3.42	0	No	No	8	5	2	1
R:R:V103	R:R:V157	6.41	0	No	No	5	9	1	2
R:R:F107	R:R:R340	7.48	0	No	No	8	9	2	1
R:R:V157	R:R:Y174	3.79	0	No	Yes	9	7	2	1
R:R:C172	R:R:R161	5.57	0	No	Yes	8	8	2	1
R:R:G173	R:R:R161	6	0	No	Yes	1	8	2	1
R:R:R161	R:R:Y174	13.38	1	Yes	Yes	8	7	1	1
R:R:R340	R:R:Y393	4.12	1	No	Yes	9	9	1	1
R:R:H394	R:R:Y393	6.53	1	Yes	Yes	9	9	2	1
R:R:I421	R:R:Y393	6.04	1	No	Yes	4	9	1	1
R:R:D417	R:R:I421	8.4	1	No	No	8	4	1	1
R:R:L82	R:R:M27	2.83	0	No	No	7	6	1	2
R:R:L30	R:R:L79	2.77	0	No	No	6	6	1	2
R:R:Y160	R:R:Y174	1.99	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZWG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	255
Number of Links	278
Number of Hubs	27
Number of Links mediated by Hubs	114
Number of Communities	4
Number of Nodes involved in Communities	41
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	48911
Length Of Smallest Path	3
Average Path Length	13.1669
Length of Longest Path	27
Minimum Path Strength	1.35
Average Path Strength	6.00833
Maximum Path Strength	25.52
Minimum Path Correlation	0.7
Average Path Correlation	0.918196
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	46.0786
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.0548
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • amyloid-beta binding • peptide binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • catecholamine binding • norepinephrine binding • complement component C3a receptor activity • complement receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • response to nutrient levels • multicellular organismal-level homeostasis • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to cold • response to temperature stimulus • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of developmental process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • ossification • biomineral tissue development • regulation of multicellular organismal development • bone mineralization • tissue development • positive regulation of bone mineralization • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • negative regulation of cardiac muscle cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • regulation of striated muscle cell apoptotic process • negative regulation of muscle cell apoptotic process • negative regulation of striated muscle cell apoptotic process • muscle contraction • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • import into cell • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • heart process • regulation of actin filament-based process • regulation of heart contraction • cardiac muscle contraction • striated muscle contraction • circulatory system process • actin filament-based process • positive regulation of actin filament-based movement • blood circulation • cardiac muscle cell contraction • regulation of cardiac muscle contraction • positive regulation of cardiac muscle cell contraction • actin filament-based movement • regulation of blood circulation • regulation of striated muscle contraction • regulation of actin filament-based movement • regulation of cardiac muscle cell contraction • actin-mediated cell contraction • heart contraction • positive regulation of organelle organization • catabolic process • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • positive regulation of catabolic process • regulation of macroautophagy • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • positive regulation of striated muscle cell apoptotic process • positive regulation of apoptotic process • positive regulation of muscle cell apoptotic process • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • positive regulation of signaling • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • cellular response to amyloid-beta • response to amyloid-beta • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • locomotion • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • granulocyte chemotaxis • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • regulation of cytokine production • cytokine production • regulation of vascular endothelial growth factor production • vascular endothelial growth factor production • positive regulation of gene expression • positive regulation of vascular endothelial growth factor production • positive regulation of cytokine production • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • calcium-mediated signaling • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • receptor complex • intercellular bridge • endosome membrane • endosome • apical part of cell • apical plasma membrane • mitotic spindle • spindle • early endosome • specific granule membrane • secretory granule membrane • specific granule • azurophil granule • primary lysosome • azurophil granule membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8ZWG_nogp_Chain_R N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I N R C G Y K L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KVP	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-	Go/β1/γ2	2.79	2025-11-26	10.1101/2025.05.26.656101
	9KVP (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-		2.79	2025-11-26	10.1101/2025.05.26.656101
	9KZ2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-	Go/β1/γ2	3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-		3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-	Go/β1/γ2	3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZ8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-		3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZK	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-	Go/β1/γ2	3.54	2025-11-26	10.1101/2025.05.26.656101
	9KZK (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-		3.54	2025-11-26	10.1101/2025.05.26.656101
	9L0H	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-	Go/β1/γ2	3.57	2025-11-26	10.1101/2025.05.26.656101
	9L0H (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-		3.57	2025-11-26	10.1101/2025.05.26.656101
	9UMJ	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-	Go/β1/γ2	3.38	2025-11-26	10.1101/2025.05.26.656101
	9UMJ (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-		3.38	2025-11-26	10.1101/2025.05.26.656101
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWF (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9KV6	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV6 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	3.17	2025-11-26	10.1101/2025.05.26.656101
	9KV8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		3.17	2025-11-26	10.1101/2025.05.26.656101

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