psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L30	6.71	Yes	No	0	0	6
2	L:L:?1	R:R:S78	17.28	Yes	No	0	0	8
3	L:L:?1	R:R:H81	14.01	Yes	No	1	0	7
4	L:L:?1	R:R:L82	5.03	Yes	No	0	0	7
5	L:L:?1	R:R:W88	3.45	Yes	Yes	1	0	9
6	L:L:?1	R:R:I98	3.46	Yes	No	1	0	8
7	L:L:?1	R:R:I102	6.91	Yes	No	0	0	8
8	L:L:?1	R:R:V103	3.61	Yes	No	0	0	5
9	L:L:?1	R:R:R161	2.94	Yes	Yes	1	0	8
10	L:L:?1	R:R:Y174	8.52	Yes	Yes	1	0	7
11	L:L:?1	R:R:R340	5.15	Yes	No	1	0	9
12	L:L:?1	R:R:Y393	27.69	Yes	Yes	1	0	9
13	L:L:?1	R:R:G397	3.11	Yes	No	0	0	8
14	L:L:?1	R:R:D417	10.68	Yes	No	1	0	8
15	L:L:?1	R:R:I421	12.1	Yes	No	1	0	4
16	R:R:I24	R:R:N19	8.5	No	No	0	7	1
17	R:R:E20	R:R:P21	3.14	Yes	No	3	4	6
18	R:R:E20	R:R:P22	11	Yes	No	3	4	4
19	R:R:E20	R:R:V23	7.13	Yes	No	0	4	4
20	R:R:E20	R:R:S415	5.75	Yes	No	0	4	5
21	R:R:P21	R:R:P22	5.84	No	No	3	6	4
22	R:R:M27	R:R:V23	3.04	No	No	0	6	4
23	R:R:I29	R:R:L25	5.71	No	No	0	7	5
24	R:R:L25	R:R:V419	4.47	No	No	0	5	5
25	R:R:S26	R:R:V419	3.23	No	No	0	8	5
26	R:R:L32	R:R:V28	2.98	No	No	0	6	6
27	R:R:A422	R:R:I29	3.25	No	No	0	8	7
28	R:R:A422	R:R:L30	3.15	No	No	0	8	6
29	R:R:F34	R:R:L35	3.65	Yes	No	0	7	6
30	R:R:F34	R:R:L38	9.74	Yes	No	0	7	7
31	R:R:F34	R:R:P76	5.78	Yes	No	0	7	9
32	R:R:C429	R:R:G37	3.92	No	No	0	9	9
33	R:R:L38	R:R:P39	8.21	No	No	0	7	7
34	R:R:D68	R:R:N41	8.08	Yes	No	1	9	9
35	R:R:N41	R:R:P432	14.66	No	No	1	9	9
36	R:R:L43	R:R:V47	2.98	No	No	0	8	8
37	R:R:I450	R:R:L43	4.28	No	No	0	4	8
38	R:R:T65	R:R:V44	3.17	No	No	0	9	9
39	R:R:L437	R:R:V44	2.98	No	No	0	7	9
40	R:R:F442	R:R:V44	6.55	Yes	No	0	9	9
41	R:R:L45	R:R:T65	10.32	No	No	0	8	9
42	R:R:L50	R:R:W46	7.97	No	No	0	4	6
43	R:R:K51	R:R:W46	4.64	No	No	4	9	6
44	R:R:S449	R:R:W46	3.71	No	No	4	9	6
45	R:R:F442	R:R:V47	3.93	Yes	No	0	9	8
46	R:R:S449	R:R:V47	4.85	No	No	0	9	8
47	R:R:A48	R:R:L62	3.15	No	No	0	7	8
48	R:R:G49	R:R:L62	3.42	No	No	0	7	8
49	R:R:K51	R:R:S449	6.12	No	No	4	9	9
50	R:R:M52	R:R:Q53	4.08	Yes	No	0	9	6
51	R:R:M52	R:R:T58	3.01	Yes	No	0	9	8
52	R:R:F442	R:R:M52	6.22	Yes	Yes	0	9	9
53	R:R:I59	R:R:R54	3.76	No	No	0	6	7
54	R:R:T55	R:R:T58	7.85	No	No	0	9	8
55	R:R:V56	R:R:W60	3.68	No	Yes	0	8	8
56	R:R:R134	R:R:V56	15.69	Yes	No	0	9	8
57	R:R:A139	R:R:V56	3.39	No	No	0	7	8
58	R:R:N57	R:R:R134	6.03	No	Yes	0	8	9
59	R:R:L62	R:R:T58	2.95	No	No	0	8	8
60	R:R:I59	R:R:V136	3.07	No	No	0	6	7
61	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
62	R:R:I116	R:R:W60	7.05	No	Yes	0	9	8
63	R:R:I142	R:R:W60	3.52	No	Yes	0	5	8
64	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
65	R:R:A436	R:R:F61	4.16	No	No	0	8	8
66	R:R:H63	R:R:L112	3.86	Yes	No	0	8	9
67	R:R:C143	R:R:H63	14.74	No	Yes	0	8	8
68	R:R:H63	R:R:W147	6.35	Yes	Yes	0	8	9
69	R:R:D68	R:R:L64	8.14	Yes	Yes	1	9	9
70	R:R:L64	R:R:S109	3	Yes	Yes	1	9	9
71	R:R:L113	R:R:L64	4.15	No	Yes	1	8	9
72	R:R:L64	R:R:N431	5.49	Yes	Yes	1	9	9
73	R:R:D68	R:R:S109	2.94	Yes	Yes	1	9	9
74	R:R:D68	R:R:S428	7.36	Yes	No	0	9	9
75	R:R:D68	R:R:P432	3.22	Yes	No	1	9	9
76	R:R:L69	R:R:L73	5.54	No	No	0	7	8
77	R:R:L70	R:R:N105	8.24	No	No	0	6	9
78	R:R:C71	R:R:S428	6.89	No	No	0	8	9
79	R:R:I102	R:R:S74	6.19	No	No	0	8	9
80	R:R:L75	R:R:S425	3	No	No	0	9	8
81	R:R:G86	R:R:H81	3.18	No	No	0	7	7
82	R:R:H81	R:R:W88	8.46	No	Yes	1	7	9
83	R:R:W88	R:R:Y90	20.26	Yes	No	0	9	7
84	R:R:L94	R:R:W88	3.42	No	Yes	0	8	9
85	R:R:I98	R:R:W88	4.7	No	Yes	1	8	9
86	R:R:P89	R:R:Y90	5.56	No	No	0	8	7
87	R:R:K96	R:R:R92	17.33	No	No	0	8	1
88	R:R:E162	R:R:R92	13.96	No	No	0	5	1
89	R:R:F93	R:R:L97	3.65	No	No	0	4	6
90	R:R:C172	R:R:C95	7.28	No	No	0	8	9
91	R:R:F158	R:R:K96	4.96	No	No	0	8	8
92	R:R:I101	R:R:L97	7.14	No	No	0	5	6
93	R:R:I98	R:R:P99	5.08	No	No	0	8	8
94	R:R:P99	R:R:R161	10.09	No	Yes	0	8	8
95	R:R:I101	R:R:N105	4.25	No	No	0	5	9
96	R:R:I102	R:R:M106	4.37	No	No	0	8	9
97	R:R:C154	R:R:V103	3.42	No	No	0	8	5
98	R:R:V103	R:R:V157	6.41	No	No	0	5	9
99	R:R:L104	R:R:W147	3.42	No	Yes	0	8	9
100	R:R:C154	R:R:L104	4.76	No	No	0	8	8
101	R:R:M106	R:R:W390	5.82	No	Yes	0	9	9
102	R:R:M106	R:R:S425	3.07	No	No	0	9	8
103	R:R:F107	R:R:F111	4.29	No	Yes	0	8	8
104	R:R:F107	R:R:M153	6.22	No	No	0	8	8
105	R:R:F107	R:R:R340	7.48	No	No	0	8	9
106	R:R:A108	R:R:W147	6.48	No	Yes	0	9	9
107	R:R:N431	R:R:S109	2.98	Yes	Yes	1	9	9
108	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
109	R:R:V110	R:R:W390	7.36	No	Yes	0	9	9
110	R:R:F111	R:R:I146	7.54	Yes	No	0	8	8
111	R:R:F111	R:R:V149	3.93	Yes	No	0	8	4
112	R:R:I146	R:R:L112	4.28	No	No	0	8	9
113	R:R:L113	R:R:N431	12.36	No	Yes	1	8	9
114	R:R:L113	R:R:Y435	14.07	No	Yes	1	8	9
115	R:R:P348	R:R:T114	6.99	Yes	No	0	9	8
116	R:R:I351	R:R:T114	4.56	No	No	0	6	8
117	R:R:I116	R:R:R120	6.26	No	No	1	9	9
118	R:R:I116	R:R:Y435	3.63	No	Yes	1	9	9
119	R:R:M352	R:R:S117	6.13	No	No	1	8	9
120	R:R:C355	R:R:S117	3.44	No	No	0	9	9
121	R:R:S117	R:R:Y356	3.82	No	Yes	1	9	9
122	R:R:I351	R:R:L118	4.28	No	No	0	6	8
123	R:R:D119	R:R:V123	4.38	No	No	2	9	5
124	R:R:D119	R:R:R134	15.48	No	Yes	2	9	9
125	R:R:R120	R:R:Y435	6.17	No	Yes	1	9	9
126	R:R:C121	R:R:C355	7.28	No	No	0	9	9
127	R:R:C121	R:R:F358	5.59	No	No	0	9	6
128	R:R:C130	R:R:L122	4.76	No	No	0	7	7
129	R:R:C130	R:R:V123	5.12	No	No	2	7	5
130	R:R:R134	R:R:V123	3.92	Yes	No	2	9	5
131	R:R:F125	R:R:K126	11.17	No	No	0	6	6
132	R:R:F125	R:R:F358	8.57	No	No	0	6	6
133	R:R:H133	R:R:W129	12.7	No	No	0	8	6
134	R:R:M138	R:R:W129	3.49	No	No	0	6	6
135	R:R:C130	R:R:R134	4.18	No	Yes	2	7	9
136	R:R:H133	R:R:N132	3.83	No	No	0	8	8
137	R:R:G137	R:R:N135	3.39	No	No	0	5	5
138	R:R:F151	R:R:I155	3.77	No	No	0	5	5
139	R:R:M153	R:R:V343	3.04	No	No	0	8	4
140	R:R:I155	R:R:P156	3.39	No	No	0	5	9
141	R:R:I336	R:R:P156	5.08	No	No	0	7	9
142	R:R:V157	R:R:Y174	3.79	No	Yes	0	9	7
143	R:R:V159	R:R:Y160	6.31	No	No	0	4	8
144	R:R:I336	R:R:Y160	4.84	No	No	0	7	8
145	R:R:C172	R:R:R161	5.57	No	Yes	0	8	8
146	R:R:G173	R:R:R161	6	No	Yes	0	1	8
147	R:R:R161	R:R:Y174	13.38	Yes	Yes	1	8	7
148	R:R:L401	R:R:V334	2.98	Yes	No	0	7	4
149	R:R:L401	R:R:T337	5.9	Yes	No	0	7	7
150	R:R:R340	R:R:Y393	4.12	No	Yes	1	9	9
151	R:R:F345	R:R:L341	4.87	Yes	Yes	1	9	6
152	R:R:L341	R:R:L346	8.3	Yes	No	1	6	8
153	R:R:H394	R:R:L341	3.86	Yes	Yes	1	9	6
154	R:R:L347	R:R:V342	2.98	No	No	0	7	6
155	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
156	R:R:F345	R:R:L346	3.65	Yes	No	1	9	8
157	R:R:F345	R:R:T391	6.49	Yes	Yes	0	9	6
158	R:R:F345	R:R:H394	21.5	Yes	Yes	1	9	9
159	R:R:M352	R:R:Y356	4.79	No	Yes	1	8	9
160	R:R:F386	R:R:M352	3.73	No	No	0	9	8
161	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	9
162	R:R:V382	R:R:Y356	5.05	No	Yes	1	8	9
163	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
164	R:R:Y356	R:R:Y435	2.98	Yes	Yes	1	9	9
165	R:R:F358	R:R:R362	6.41	No	No	0	6	7
166	R:R:Q364	R:R:V360	5.73	No	No	0	5	6
167	R:R:F376	R:R:V360	9.18	No	No	0	4	6
168	R:R:F361	R:R:R365	4.28	No	No	0	4	4
169	R:R:F368	R:R:R367	12.83	No	No	0	5	6
170	R:R:Q372	R:R:T375	5.67	No	No	0	5	7
171	R:R:F376	R:R:V380	7.87	No	No	0	4	3
172	R:R:V382	R:R:Y435	3.79	No	Yes	1	8	9
173	R:R:L387	R:R:V383	2.98	No	No	0	6	8
174	R:R:F430	R:R:V385	3.93	No	No	0	7	7
175	R:R:L434	R:R:V385	4.47	No	No	0	9	7
176	R:R:F386	R:R:W390	14.03	No	Yes	0	9	9
177	R:R:L387	R:R:T391	2.95	No	Yes	0	6	6
178	R:R:C389	R:R:W390	3.92	No	Yes	1	9	9
179	R:R:C389	R:R:N427	9.45	No	No	1	9	9
180	R:R:H394	R:R:W390	3.17	Yes	Yes	1	9	9
181	R:R:N427	R:R:W390	14.69	No	Yes	1	9	9
182	R:R:P392	R:R:T391	5.25	No	Yes	0	9	6
183	R:R:I395	R:R:T391	3.04	No	Yes	0	5	6
184	R:R:C420	R:R:P392	3.77	No	No	0	6	9
185	R:R:H394	R:R:Y393	6.53	Yes	Yes	1	9	9
186	R:R:I421	R:R:Y393	6.04	No	Yes	1	4	9
187	R:R:F396	R:R:L413	6.09	No	No	0	4	7
188	R:R:C420	R:R:F396	9.78	No	No	0	6	4
189	R:R:L401	R:R:S400	6.01	Yes	No	0	7	2
190	R:R:L409	R:R:T403	5.9	No	No	0	3	2
191	R:R:L413	R:R:T403	4.42	No	No	0	7	2
192	R:R:D404	R:R:P405	6.44	No	No	0	4	4
193	R:R:D404	R:R:E406	9.09	No	No	0	4	1
194	R:R:D404	R:R:T407	7.23	No	No	0	4	7
195	R:R:L409	R:R:T412	2.95	No	No	0	3	6
196	R:R:G410	R:R:L413	5.13	No	No	0	3	7
197	R:R:V419	R:R:W416	7.36	No	No	0	5	7
198	R:R:D417	R:R:I421	8.4	No	No	1	8	4
199	R:R:A426	R:R:F430	4.16	No	No	0	8	7
200	R:R:N427	R:R:N431	12.26	No	Yes	1	9	9
201	R:R:N431	R:R:Y435	3.49	Yes	Yes	1	9	9
202	R:R:F433	R:R:P432	2.89	No	No	0	6	9
203	R:R:F433	R:R:L437	4.87	No	No	0	6	7
204	R:R:K444	R:R:K445	5.75	No	No	0	5	7
205	R:R:K444	R:R:Q448	9.49	No	No	0	5	7
206	R:R:K445	R:R:M52	2.88	No	Yes	0	7	9
207	R:R:I395	R:R:L399	2.85	No	No	0	5	9
208	R:R:L82	R:R:M27	2.83	No	No	0	7	6
209	R:R:I128	R:R:N132	2.83	No	No	0	7	8
210	R:R:H418	R:R:S26	2.79	No	No	0	4	8
211	R:R:C389	R:R:F430	2.79	No	No	0	9	7
212	R:R:L30	R:R:L79	2.77	No	No	0	6	6
213	R:R:A150	R:R:F111	2.77	No	Yes	0	9	8
214	R:R:L333	R:R:L401	2.77	No	Yes	0	3	7
215	R:R:A436	R:R:F442	2.77	No	Yes	0	8	9
216	R:R:K370	R:R:Q372	2.71	No	No	0	7	5
217	R:R:H63	R:R:I59	2.65	Yes	No	0	8	6
218	R:R:F77	R:R:S74	2.64	No	No	0	8	9
219	R:R:N170	R:R:Q87	2.64	No	No	0	4	6
220	R:R:F158	R:R:S100	2.64	No	No	0	8	8
221	R:R:N132	R:R:Q131	2.64	No	No	0	8	9
222	R:R:R362	R:R:V124	2.62	No	No	0	7	9
223	R:R:A424	R:R:W390	2.59	No	Yes	0	9	9
224	R:R:I163	R:R:R92	2.51	No	No	0	6	1
225	R:R:M138	R:R:R134	2.48	No	Yes	0	6	9
226	R:R:F34	R:R:L75	2.44	Yes	No	0	7	9
227	R:R:F93	R:R:L94	2.44	No	No	0	4	8
228	R:R:G40	R:R:P39	2.03	No	No	0	9	7
229	R:R:Y160	R:R:Y174	1.99	No	Yes	0	8	7
230	R:R:C72	R:R:G37	1.96	No	No	0	8	9
231	R:R:A369	R:R:G366	1.95	No	No	0	5	2
232	R:R:G410	R:R:T407	1.82	No	No	0	3	7
233	R:R:P408	R:R:T407	1.75	No	No	0	4	7
234	R:R:C72	R:R:S428	1.72	No	No	0	8	9
235	R:R:A67	R:R:S109	1.71	No	Yes	0	9	9
236	R:R:C140	R:R:V136	1.71	No	No	0	4	7
237	R:R:C145	R:R:V149	1.71	No	No	0	6	4
238	R:R:C429	R:R:T33	1.69	No	No	0	9	8
239	R:R:M414	R:R:P405	1.68	No	No	0	2	4
240	R:R:K126	R:R:P127	1.67	No	No	0	6	9
241	R:R:L84	R:R:P89	1.64	No	No	0	8	8
242	R:R:C172	R:R:I163	1.64	No	No	0	8	6
243	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
244	R:R:L423	R:R:P392	1.64	No	No	0	8	9
245	R:R:S31	R:R:V28	1.62	No	No	0	7	6
246	R:R:S349	R:R:V350	1.62	No	No	0	4	4
247	R:R:V148	R:R:V152	1.6	No	No	0	5	5
248	R:R:V378	R:R:V382	1.6	No	No	0	8	8
249	R:R:V381	R:R:V385	1.6	No	No	0	7	7
250	R:R:C429	R:R:L36	1.59	No	No	0	9	8
251	R:R:T339	R:R:V343	1.59	No	No	0	8	4
252	R:R:I353	R:R:S357	1.55	No	No	0	5	6
253	R:R:I24	R:R:V28	1.54	No	No	0	7	6
254	R:R:I359	R:R:V124	1.54	No	No	0	9	9
255	R:R:I338	R:R:V334	1.54	No	No	0	6	4
256	R:R:I338	R:R:V342	1.54	No	No	0	6	6
257	R:R:I353	R:R:V383	1.54	No	No	0	5	8
258	R:R:M363	R:R:V124	1.52	No	No	0	7	9
259	R:R:M153	R:R:V152	1.52	No	No	0	8	5
260	R:R:I359	R:R:T375	1.52	No	No	0	9	7
261	R:R:K374	R:R:V378	1.52	No	No	0	9	8
262	R:R:G366	R:R:R365	1.5	No	No	0	2	4
263	R:R:L341	R:R:V398	1.49	Yes	No	0	6	7
264	R:R:L438	R:R:V378	1.49	No	No	0	7	8
265	R:R:L423	R:R:V388	1.49	No	No	0	8	6
266	R:R:G91	R:R:Y90	1.45	No	No	0	9	7
267	R:R:K440	R:R:K444	1.44	No	No	0	7	5
268	R:R:I163	R:R:N170	1.42	No	No	0	6	4
269	R:R:G144	R:R:W147	1.41	No	Yes	0	5	9
270	R:R:D441	R:R:M52	1.39	No	Yes	0	7	9
271	R:R:L38	R:R:L73	1.38	No	No	0	7	8
272	R:R:L45	R:R:L66	1.38	No	No	0	8	4
273	R:R:L66	R:R:L70	1.38	No	No	0	4	6
274	R:R:E162	R:R:K175	1.35	No	No	0	5	5
275	R:R:F386	R:R:S349	1.32	No	No	0	9	4
276	R:R:R377	R:R:V381	1.31	No	No	0	5	7
277	R:R:M414	R:R:R171	1.24	No	No	0	2	1
278	R:R:L438	R:R:R443	1.21	No	No	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.71	15	1	0
2	R:R:E20	6.755	4	3	4
3	R:R:F34	5.4025	4	0	7
4	R:R:M52	3.516	5	0	9
5	R:R:W60	4.412	5	0	8
6	R:R:H63	6.9	4	0	8
7	R:R:L64	5.195	4	1	9
8	R:R:D68	5.948	5	1	9
9	R:R:W88	8.058	5	1	9
10	R:R:S109	2.6575	4	1	9
11	R:R:F111	4.6325	4	0	8
12	R:R:R134	7.96333	6	2	9
13	R:R:W147	4.415	4	0	9
14	R:R:R161	7.596	5	1	8
15	R:R:Y174	6.92	4	1	7
16	R:R:L341	4.63	4	1	6
17	R:R:F345	9.1275	4	1	9
18	R:R:P348	4.055	4	0	9
19	R:R:Y356	4.295	6	1	9
20	R:R:W390	7.36857	7	1	9
21	R:R:T391	4.4325	4	0	6
22	R:R:Y393	11.095	4	1	9
23	R:R:H394	8.765	4	1	9
24	R:R:L401	4.415	4	0	7
25	R:R:N431	7.316	5	1	9
26	R:R:Y435	5.68833	6	1	9
27	R:R:F442	4.8675	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L82	17.5103	5.03	Yes	No	0	0	7
2	R:R:L82	R:R:M27	15.1862	2.83	No	No	0	7	6
3	R:R:M27	R:R:V23	12.8559	3.04	No	No	0	6	4
4	R:R:E20	R:R:V23	10.258	7.13	Yes	No	0	4	4
5	L:L:?1	R:R:L30	23.1139	6.71	Yes	No	0	0	6
6	R:R:A422	R:R:L30	18.2648	3.15	No	No	0	8	6
7	R:R:A422	R:R:I29	15.6912	3.25	No	No	0	8	7
8	R:R:I29	R:R:L25	13.1054	5.71	No	No	0	7	5
9	R:R:L25	R:R:V419	10.5074	4.47	No	No	0	5	5
10	L:L:?1	R:R:I102	50.724	6.91	Yes	No	0	0	8
11	R:R:I102	R:R:M106	52.2451	4.37	No	No	0	8	9
12	R:R:M106	R:R:S425	16.622	3.07	No	No	0	9	8
13	R:R:L75	R:R:S425	15.0036	3	No	No	0	9	8
14	R:R:F34	R:R:L75	13.4765	2.44	Yes	No	0	7	9
15	R:R:M106	R:R:W390	58.5666	5.82	No	Yes	0	9	9
16	R:R:N427	R:R:W390	92.1818	14.69	No	Yes	1	9	9
17	R:R:N427	R:R:N431	96.8849	12.26	No	Yes	1	9	9
18	R:R:L64	R:R:N431	58.5787	5.49	Yes	Yes	1	9	9
19	R:R:D68	R:R:L64	75.4563	8.14	Yes	Yes	1	9	9
20	R:R:D68	R:R:S428	28.3159	7.36	Yes	No	0	9	9
21	R:R:C72	R:R:S428	20.2847	1.72	No	No	0	8	9
22	R:R:C72	R:R:G37	16.2509	1.96	No	No	0	8	9
23	R:R:C429	R:R:G37	12.2049	3.92	No	No	0	9	9
24	L:L:?1	R:R:Y393	55.8895	27.69	Yes	Yes	1	0	9
25	R:R:H394	R:R:Y393	69.9623	6.53	Yes	Yes	1	9	9
26	R:R:H394	R:R:W390	75.0548	3.17	Yes	Yes	1	9	9
27	R:R:N431	R:R:S109	60.2762	2.98	Yes	Yes	1	9	9
28	R:R:D68	R:R:S109	57.4045	2.94	Yes	Yes	1	9	9
29	R:R:D68	R:R:P432	100	3.22	Yes	No	1	9	9
30	L:L:?1	R:R:W88	26.4663	3.45	Yes	Yes	1	0	9
31	R:R:L94	R:R:W88	19.2808	3.42	No	Yes	0	8	9
32	R:R:F93	R:R:L94	17.6138	2.44	No	No	0	4	8
33	R:R:F93	R:R:L97	15.965	3.65	No	No	0	4	6
34	R:R:I101	R:R:L97	14.4074	7.14	No	No	0	5	6
35	R:R:I101	R:R:N105	13.0506	4.25	No	No	0	5	9
36	R:R:L70	R:R:N105	11.8946	8.24	No	No	0	6	9
37	R:R:L66	R:R:L70	11.6938	1.38	No	No	0	4	6
38	R:R:L45	R:R:L66	12.1562	1.38	No	No	0	8	4
39	R:R:L45	R:R:T65	13.799	10.32	No	No	0	8	9
40	R:R:T65	R:R:V44	15.7885	3.17	No	No	0	9	9
41	R:R:F442	R:R:V44	86.7182	6.55	Yes	No	0	9	9
42	R:R:F442	R:R:V47	27.8292	3.93	Yes	No	0	9	8
43	R:R:F433	R:R:P432	96.5381	2.89	No	No	0	6	9
44	R:R:F433	R:R:L437	92.8936	4.87	No	No	0	6	7
45	R:R:L437	R:R:V44	89.2918	2.98	No	No	0	7	9
46	R:R:S449	R:R:V47	16.3239	4.85	No	No	0	9	8
47	R:R:F442	R:R:M52	48.3999	6.22	Yes	Yes	0	9	9
48	R:R:M52	R:R:T58	20.376	3.01	Yes	No	0	9	8
49	R:R:L62	R:R:T58	12.2597	2.95	No	No	0	8	8
50	L:L:?1	R:R:V103	18.7333	3.61	Yes	No	0	0	5
51	R:R:C154	R:R:V103	15.8554	3.42	No	No	0	8	5
52	R:R:C154	R:R:L104	13.7503	4.76	No	No	0	8	8
53	R:R:L104	R:R:W147	13.726	3.42	No	Yes	0	8	9
54	R:R:H63	R:R:W147	14.1823	6.35	Yes	Yes	0	8	9
55	R:R:C143	R:R:H63	21.0635	14.74	No	Yes	0	8	8
56	R:R:C143	R:R:W60	21.9031	3.92	No	Yes	0	8	8
57	R:R:V56	R:R:W60	26.1317	3.68	No	Yes	0	8	8
58	R:R:R134	R:R:V56	22.4203	15.69	Yes	No	0	9	8
59	R:R:F107	R:R:R340	16.3178	7.48	No	No	0	8	9
60	L:L:?1	R:R:R161	34.0411	2.94	Yes	Yes	1	0	8
61	R:R:C172	R:R:R161	28.3706	5.57	No	Yes	0	8	8
62	R:R:C172	R:R:I163	23.3208	1.64	No	No	0	8	6
63	R:R:I163	R:R:R92	15.6547	2.51	No	No	0	6	1
64	L:L:?1	R:R:Y174	19.3721	8.52	Yes	Yes	1	0	7
65	R:R:V110	R:R:W390	28.468	7.36	No	Yes	0	9	9
66	R:R:P348	R:R:V110	26.4967	3.53	Yes	No	0	9	9
67	R:R:N431	R:R:Y435	51.7644	3.49	Yes	Yes	1	9	9
68	R:R:F386	R:R:W390	28.614	14.03	No	Yes	0	9	9
69	R:R:F386	R:R:M352	24.2881	3.73	No	No	0	9	8
70	R:R:M352	R:R:S117	15.3018	6.13	No	No	1	8	9
71	R:R:C355	R:R:S117	29.1494	3.44	No	No	0	9	9
72	R:R:C121	R:R:C355	26.9591	7.28	No	No	0	9	9
73	R:R:C121	R:R:F358	24.7445	5.59	No	No	0	9	6
74	R:R:M138	R:R:R134	11.6513	2.48	No	Yes	0	6	9
75	R:R:Y160	R:R:Y174	16.4091	1.99	No	Yes	0	8	7
76	R:R:I336	R:R:Y160	10.8907	4.84	No	No	0	7	8
77	R:R:L347	R:R:P348	16.4578	1.64	No	Yes	0	7	9
78	R:R:L347	R:R:V342	14.4135	2.98	No	No	0	7	6
79	R:R:I338	R:R:V342	12.357	1.54	No	No	0	6	6
80	R:R:I338	R:R:V334	10.2884	1.54	No	No	0	6	4
81	R:R:F345	R:R:H394	29.91	21.5	Yes	Yes	1	9	9
82	R:R:F345	R:R:T391	28.0239	6.49	Yes	Yes	0	9	6
83	R:R:L387	R:R:T391	23.1626	2.95	No	Yes	0	6	6
84	R:R:L387	R:R:V383	23.3816	2.98	No	No	0	6	8
85	R:R:F358	R:R:R362	15.8128	6.41	No	No	0	6	7
86	R:R:R362	R:R:V124	13.5374	2.62	No	No	0	7	9
87	R:R:C389	R:R:F430	12.6612	2.79	No	No	0	9	7
88	R:R:P392	R:R:T391	39.0302	5.25	No	Yes	0	9	6
89	R:R:C420	R:R:P392	32.3315	3.77	No	No	0	6	9
90	R:R:C420	R:R:F396	30.0621	9.78	No	No	0	6	4
91	R:R:F396	R:R:L413	27.7866	6.09	No	No	0	4	7
92	R:R:G410	R:R:L413	18.788	5.13	No	No	0	3	7
93	R:R:G410	R:R:T407	16.4578	1.82	No	No	0	3	7
94	R:R:D404	R:R:T407	11.7608	7.23	No	No	0	4	7
95	R:R:K445	R:R:M52	16.3178	2.88	No	Yes	0	7	9
96	R:R:K444	R:R:K445	12.2597	5.75	No	No	0	5	7
97	R:R:V378	R:R:V382	12.8742	1.6	No	No	0	8	8
98	R:R:I116	R:R:Y435	37.0285	3.63	No	Yes	1	9	9
99	R:R:I116	R:R:W60	35.6291	7.05	No	Yes	0	9	8
100	R:R:V383	R:R:Y356	25.578	3.79	No	Yes	0	8	9
101	R:R:R340	R:R:Y393	11.5113	4.12	No	Yes	1	9	9
102	R:R:L113	R:R:L64	18.7941	4.15	No	Yes	1	8	9
103	R:R:L113	R:R:Y435	19.0253	14.07	No	Yes	1	8	9
104	R:R:Y356	R:R:Y435	37.9776	2.98	Yes	Yes	1	9	9
105	R:R:S117	R:R:Y356	16.0197	3.82	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L30	6.71	1	Yes	No	0	6	0	1
L:L:?1	R:R:S78	17.28	1	Yes	No	0	8	0	1
L:L:?1	R:R:H81	14.01	1	Yes	No	0	7	0	1
L:L:?1	R:R:L82	5.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:W88	3.45	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I98	3.46	1	Yes	No	0	8	0	1
L:L:?1	R:R:I102	6.91	1	Yes	No	0	8	0	1
L:L:?1	R:R:V103	3.61	1	Yes	No	0	5	0	1
L:L:?1	R:R:R161	2.94	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y174	8.52	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R340	5.15	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y393	27.69	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G397	3.11	1	Yes	No	0	8	0	1
L:L:?1	R:R:D417	10.68	1	Yes	No	0	8	0	1
L:L:?1	R:R:I421	12.1	1	Yes	No	0	4	0	1
R:R:A422	R:R:L30	3.15	0	No	No	8	6	2	1
R:R:I102	R:R:S74	6.19	0	No	No	8	9	1	2
R:R:G86	R:R:H81	3.18	0	No	No	7	7	2	1
R:R:H81	R:R:W88	8.46	1	No	Yes	7	9	1	1
R:R:W88	R:R:Y90	20.26	1	Yes	No	9	7	1	2
R:R:L94	R:R:W88	3.42	0	No	Yes	8	9	2	1
R:R:I98	R:R:W88	4.7	1	No	Yes	8	9	1	1
R:R:I98	R:R:P99	5.08	1	No	No	8	8	1	2
R:R:P99	R:R:R161	10.09	0	No	Yes	8	8	2	1
R:R:I102	R:R:M106	4.37	0	No	No	8	9	1	2
R:R:C154	R:R:V103	3.42	0	No	No	8	5	2	1
R:R:V103	R:R:V157	6.41	0	No	No	5	9	1	2
R:R:F107	R:R:R340	7.48	0	No	No	8	9	2	1
R:R:V157	R:R:Y174	3.79	0	No	Yes	9	7	2	1
R:R:C172	R:R:R161	5.57	0	No	Yes	8	8	2	1
R:R:G173	R:R:R161	6	0	No	Yes	1	8	2	1
R:R:R161	R:R:Y174	13.38	1	Yes	Yes	8	7	1	1
R:R:R340	R:R:Y393	4.12	1	No	Yes	9	9	1	1
R:R:H394	R:R:Y393	6.53	1	Yes	Yes	9	9	2	1
R:R:I421	R:R:Y393	6.04	1	No	Yes	4	9	1	1
R:R:D417	R:R:I421	8.4	1	No	No	8	4	1	1
R:R:L82	R:R:M27	2.83	0	No	No	7	6	1	2
R:R:L30	R:R:L79	2.77	0	No	No	6	6	1	2
R:R:Y160	R:R:Y174	1.99	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZWG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	255
Number of Links	278
Number of Hubs	27
Number of Links mediated by Hubs	114
Number of Communities	4
Number of Nodes involved in Communities	41
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	48911
Length Of Smallest Path	3
Average Path Length	13.1669
Length of Longest Path	27
Minimum Path Strength	1.35
Average Path Strength	5.89062
Maximum Path Strength	22.485
Minimum Path Correlation	0.7
Average Path Correlation	0.918196
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	46.0786
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.0548
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • complement component C3a receptor activity • complement receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of cytokine production • cytokine production • regulation of vascular endothelial growth factor production • vascular endothelial growth factor production • positive regulation of gene expression • positive regulation of vascular endothelial growth factor production • positive regulation of cytokine production • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • system development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • phospholipase C-activating G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • calcium-mediated signaling • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • specific granule membrane • secretory granule membrane • specific granule • vacuolar membrane • azurophil granule • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • centriolar satellite • cytosol • nucleoplasm • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8ZWG_nogp_Chain_R N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I N R C G Y K L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZWG_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.