psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F3	R:R:E162	3.5	No	No	0	0	5
2	L:L:F3	R:R:F164	17.15	No	No	0	0	3
3	L:L:K4	L:L:P5	5.02	No	No	0	0	0
4	L:L:K4	R:R:P405	13.38	No	No	0	0	4
5	L:L:P5	R:R:T166	10.49	No	No	5	0	1
6	L:L:P5	R:R:R171	12.97	No	Yes	5	0	1
7	L:L:M6	L:L:P7	8.39	Yes	No	0	0	0
8	L:L:M6	L:L:R10	6.2	Yes	Yes	0	0	0
9	L:L:M6	R:R:Y174	8.38	Yes	Yes	0	0	7
10	L:L:L8	R:R:H81	5.14	Yes	No	0	0	7
11	L:L:L8	R:R:I98	9.99	Yes	Yes	2	0	8
12	L:L:L8	R:R:P99	4.93	Yes	No	2	0	8
13	L:L:L8	R:R:I102	4.28	Yes	Yes	2	0	8
14	L:L:?9	L:L:R10	14.83	No	Yes	1	0	0
15	L:L:?9	R:R:Y393	3.58	No	Yes	1	0	9
16	L:L:?9	R:R:I421	11.61	No	No	0	0	4
17	L:L:R10	R:R:R340	5.33	Yes	No	0	0	9
18	L:L:R10	R:R:Y393	13.38	Yes	Yes	1	0	9
19	L:L:R10	R:R:G397	6	Yes	No	0	0	8
20	L:L:R10	R:R:D417	10.72	Yes	No	0	0	8
21	R:R:Q85	R:R:W18	13.14	No	No	0	5	1
22	R:R:E20	R:R:P22	12.58	No	Yes	0	4	4
23	R:R:E20	R:R:V23	5.7	No	No	0	4	4
24	R:R:P21	R:R:P22	7.79	No	Yes	0	6	4
25	R:R:P22	R:R:S415	3.56	Yes	No	0	4	5
26	R:R:L82	R:R:V23	7.45	No	No	0	7	4
27	R:R:I29	R:R:L25	4.28	No	No	0	7	5
28	R:R:L25	R:R:V419	4.47	No	No	0	5	5
29	R:R:H418	R:R:S26	4.18	No	No	0	4	8
30	R:R:L82	R:R:M27	11.31	No	No	0	7	6
31	R:R:A422	R:R:I29	3.25	No	No	0	8	7
32	R:R:L30	R:R:L75	6.92	Yes	Yes	3	6	9
33	R:R:L30	R:R:L79	5.54	Yes	No	3	6	6
34	R:R:F34	R:R:L38	10.96	No	No	0	7	7
35	R:R:F34	R:R:L75	6.09	No	Yes	3	7	9
36	R:R:F34	R:R:P76	10.11	No	No	3	7	9
37	R:R:C429	R:R:L36	4.76	No	No	0	9	8
38	R:R:G40	R:R:P432	4.06	No	No	0	9	9
39	R:R:D68	R:R:N41	6.73	Yes	No	0	9	9
40	R:R:N41	R:R:P432	11.4	No	No	0	9	9
41	R:R:G42	R:R:L45	3.42	No	No	0	6	8
42	R:R:T65	R:R:V44	6.35	No	No	0	9	9
43	R:R:P432	R:R:V44	3.53	No	No	0	9	9
44	R:R:L45	R:R:L69	4.15	No	No	0	8	7
45	R:R:L50	R:R:W46	6.83	No	No	0	4	6
46	R:R:S449	R:R:W46	6.18	No	No	0	9	6
47	R:R:F442	R:R:V47	6.55	Yes	No	0	9	8
48	R:R:K51	R:R:S449	7.65	No	No	0	9	9
49	R:R:M52	R:R:T58	9.03	No	No	0	9	8
50	R:R:F442	R:R:M52	9.95	Yes	No	4	9	9
51	R:R:K445	R:R:M52	8.64	No	No	4	7	9
52	R:R:T55	R:R:T58	6.28	No	No	0	9	8
53	R:R:V56	R:R:W60	3.68	No	Yes	0	8	8
54	R:R:R134	R:R:V56	7.85	Yes	No	0	9	8
55	R:R:N57	R:R:R134	3.62	No	Yes	0	8	9
56	R:R:I116	R:R:W60	3.52	Yes	Yes	0	9	8
57	R:R:D119	R:R:W60	14.52	No	Yes	0	9	8
58	R:R:A139	R:R:W60	5.19	No	Yes	0	7	8
59	R:R:I142	R:R:W60	5.87	No	Yes	0	5	8
60	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
61	R:R:F61	R:R:I116	3.77	No	Yes	0	8	9
62	R:R:A436	R:R:F61	5.55	No	No	0	8	8
63	R:R:C143	R:R:H63	13.27	No	Yes	0	8	8
64	R:R:H63	R:R:W147	7.41	Yes	Yes	0	8	9
65	R:R:D68	R:R:L64	5.43	Yes	Yes	0	9	9
66	R:R:L112	R:R:L64	4.15	No	Yes	0	9	9
67	R:R:L113	R:R:L64	5.54	Yes	Yes	1	8	9
68	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
69	R:R:A67	R:R:W147	3.89	No	Yes	0	9	9
70	R:R:D68	R:R:S109	7.36	Yes	No	0	9	9
71	R:R:D68	R:R:S428	4.42	Yes	No	0	9	9
72	R:R:D68	R:R:N431	10.77	Yes	No	0	9	9
73	R:R:L69	R:R:L73	6.92	No	No	0	7	8
74	R:R:L70	R:R:N105	6.87	No	No	0	6	9
75	R:R:C71	R:R:N105	9.45	No	No	0	8	9
76	R:R:C71	R:R:M106	4.86	No	No	0	8	9
77	R:R:C71	R:R:S428	6.89	No	No	0	8	9
78	R:R:I102	R:R:S74	10.84	Yes	No	0	8	9
79	R:R:N105	R:R:S74	4.47	No	No	0	9	9
80	R:R:L75	R:R:P76	3.28	Yes	No	3	9	9
81	R:R:L75	R:R:L79	4.15	Yes	No	3	9	6
82	R:R:F77	R:R:I98	11.3	No	Yes	0	8	8
83	R:R:H81	R:R:R171	3.39	No	Yes	0	7	1
84	R:R:H418	R:R:L82	5.14	No	No	0	4	7
85	R:R:L84	R:R:Q87	5.32	No	No	0	8	6
86	R:R:L84	R:R:P89	3.28	No	No	0	8	8
87	R:R:G86	R:R:R171	7.51	No	Yes	0	7	1
88	R:R:H169	R:R:Q87	18.54	No	No	0	3	6
89	R:R:P89	R:R:W88	9.46	No	Yes	2	8	9
90	R:R:W88	R:R:Y90	4.82	Yes	No	2	9	7
91	R:R:L94	R:R:W88	3.42	Yes	Yes	2	8	9
92	R:R:C95	R:R:W88	11.75	No	Yes	0	9	9
93	R:R:I98	R:R:W88	7.05	Yes	Yes	2	8	9
94	R:R:P89	R:R:Y90	15.3	No	No	2	8	7
95	R:R:L94	R:R:Y90	10.55	Yes	No	2	8	7
96	R:R:K96	R:R:R92	7.43	No	No	0	8	1
97	R:R:E162	R:R:R92	15.12	No	No	0	5	1
98	R:R:C172	R:R:C95	7.28	No	No	0	8	9
99	R:R:F158	R:R:K96	16.13	No	No	0	8	8
100	R:R:I98	R:R:P99	6.77	Yes	No	2	8	8
101	R:R:I102	R:R:I98	4.42	Yes	Yes	2	8	8
102	R:R:P99	R:R:R161	11.53	No	Yes	0	8	8
103	R:R:S100	R:R:V157	3.23	No	No	0	8	9
104	R:R:F158	R:R:S100	5.28	No	No	0	8	8
105	R:R:M106	R:R:V103	4.56	No	No	0	9	5
106	R:R:C154	R:R:V103	3.42	No	No	0	8	5
107	R:R:R340	R:R:V103	7.85	No	No	0	9	5
108	R:R:C154	R:R:L104	4.76	No	No	0	8	8
109	R:R:M106	R:R:W390	4.65	No	Yes	0	9	9
110	R:R:F107	R:R:M153	4.98	Yes	Yes	0	8	8
111	R:R:F107	R:R:R340	14.97	Yes	No	0	8	9
112	R:R:F107	R:R:W390	5.01	Yes	Yes	1	8	9
113	R:R:F107	R:R:Y393	5.16	Yes	Yes	1	8	9
114	R:R:A108	R:R:W147	5.19	No	Yes	0	9	9
115	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
116	R:R:F386	R:R:V110	5.24	Yes	No	1	9	9
117	R:R:V110	R:R:W390	7.36	No	Yes	1	9	9
118	R:R:F111	R:R:I146	3.77	No	No	0	8	8
119	R:R:F111	R:R:M153	7.46	No	Yes	0	8	8
120	R:R:L113	R:R:M352	4.24	Yes	Yes	1	8	8
121	R:R:F386	R:R:L113	4.87	Yes	Yes	1	9	8
122	R:R:L113	R:R:N431	4.12	Yes	No	0	8	9
123	R:R:L113	R:R:Y435	8.21	Yes	Yes	1	8	9
124	R:R:P348	R:R:T114	5.25	Yes	No	0	9	8
125	R:R:I351	R:R:T114	4.56	No	No	0	6	8
126	R:R:I116	R:R:R120	3.76	Yes	No	1	9	9
127	R:R:I116	R:R:Y435	6.04	Yes	Yes	1	9	9
128	R:R:M352	R:R:S117	6.13	Yes	No	1	8	9
129	R:R:C355	R:R:S117	6.89	No	No	0	9	9
130	R:R:S117	R:R:Y356	6.36	No	Yes	1	9	9
131	R:R:I351	R:R:L118	4.28	No	No	0	6	8
132	R:R:D119	R:R:V123	4.38	No	No	7	9	5
133	R:R:D119	R:R:R134	11.91	No	Yes	7	9	9
134	R:R:R120	R:R:Y356	5.14	No	Yes	1	9	9
135	R:R:R120	R:R:Y435	5.14	No	Yes	1	9	9
136	R:R:C121	R:R:C355	5.46	No	No	0	9	9
137	R:R:C121	R:R:F358	4.19	No	No	0	9	6
138	R:R:L122	R:R:W129	4.56	No	No	0	7	6
139	R:R:R134	R:R:V123	7.85	Yes	No	7	9	5
140	R:R:F125	R:R:F358	16.08	No	No	0	6	6
141	R:R:K126	R:R:W129	9.28	No	No	0	6	6
142	R:R:I128	R:R:P127	5.08	No	No	0	7	9
143	R:R:H133	R:R:W129	12.7	No	No	0	8	6
144	R:R:C130	R:R:R134	4.18	No	Yes	0	7	9
145	R:R:G137	R:R:N135	3.39	No	No	0	5	5
146	R:R:I142	R:R:M138	4.37	No	No	0	5	6
147	R:R:F151	R:R:I155	3.77	No	No	0	5	5
148	R:R:M153	R:R:V343	6.09	Yes	No	0	8	4
149	R:R:G344	R:R:M153	3.49	No	Yes	0	9	8
150	R:R:I155	R:R:P156	3.39	No	No	0	5	9
151	R:R:I336	R:R:P156	6.77	No	No	0	7	9
152	R:R:R161	R:R:V157	3.92	Yes	No	0	8	9
153	R:R:Y160	R:R:Y174	16.88	Yes	Yes	6	8	7
154	R:R:P332	R:R:Y160	5.56	No	Yes	0	4	8
155	R:R:L333	R:R:Y160	3.52	No	Yes	6	3	8
156	R:R:I336	R:R:Y160	3.63	No	Yes	0	7	8
157	R:R:R161	R:R:Y174	18.52	Yes	Yes	0	8	7
158	R:R:C172	R:R:I163	4.91	No	No	0	8	6
159	R:R:F164	R:R:T165	6.49	No	No	0	3	4
160	R:R:R171	R:R:T166	11.64	Yes	No	5	1	1
161	R:R:D167	R:R:N168	5.39	No	No	0	3	5
162	R:R:D167	R:R:R171	7.15	No	Yes	0	3	1
163	R:R:H169	R:R:N168	8.93	No	No	0	3	5
164	R:R:L333	R:R:Y174	7.03	No	Yes	6	3	7
165	R:R:P332	R:R:T331	3.5	No	No	0	4	4
166	R:R:L341	R:R:L346	4.15	No	No	0	6	8
167	R:R:H394	R:R:L341	12.86	No	No	0	9	6
168	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
169	R:R:F345	R:R:L346	4.87	Yes	No	0	9	8
170	R:R:F345	R:R:F386	5.36	Yes	Yes	1	9	9
171	R:R:F345	R:R:W390	5.01	Yes	Yes	1	9	9
172	R:R:F345	R:R:T391	3.89	Yes	No	0	9	6
173	R:R:F345	R:R:H394	15.84	Yes	No	0	9	9
174	R:R:L347	R:R:P348	6.57	No	Yes	0	7	9
175	R:R:M352	R:R:Y356	4.79	Yes	Yes	1	8	9
176	R:R:F386	R:R:M352	9.95	Yes	Yes	1	9	8
177	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
178	R:R:V382	R:R:Y356	5.05	No	Yes	1	8	9
179	R:R:V383	R:R:Y356	5.05	No	Yes	0	8	9
180	R:R:Y356	R:R:Y435	3.97	Yes	Yes	1	9	9
181	R:R:F361	R:R:S357	6.61	No	No	0	4	6
182	R:R:F358	R:R:R362	6.41	No	No	0	6	7
183	R:R:F376	R:R:V360	6.55	No	Yes	0	4	6
184	R:R:M363	R:R:T375	12.04	No	No	0	7	7
185	R:R:K374	R:R:V378	6.07	No	No	0	9	8
186	R:R:F376	R:R:V380	6.55	No	No	0	4	3
187	R:R:R377	R:R:V381	3.92	No	No	0	5	7
188	R:R:L434	R:R:V381	5.96	No	No	0	9	7
189	R:R:V382	R:R:Y435	5.05	No	Yes	1	8	9
190	R:R:F430	R:R:V385	3.93	No	No	0	7	7
191	R:R:L434	R:R:V385	4.47	No	No	0	9	7
192	R:R:F386	R:R:W390	8.02	Yes	Yes	1	9	9
193	R:R:C389	R:R:N427	9.45	No	No	0	9	9
194	R:R:W390	R:R:Y393	7.72	Yes	Yes	1	9	9
195	R:R:A424	R:R:W390	7.78	No	Yes	0	9	9
196	R:R:N427	R:R:W390	7.91	No	Yes	0	9	9
197	R:R:P392	R:R:T391	5.25	No	No	0	9	6
198	R:R:C420	R:R:P392	3.77	No	No	0	6	9
199	R:R:H394	R:R:Y393	13.07	No	Yes	0	9	9
200	R:R:F396	R:R:L413	6.09	Yes	Yes	0	4	7
201	R:R:D417	R:R:F396	5.97	No	Yes	0	8	4
202	R:R:C420	R:R:F396	9.78	No	Yes	0	6	4
203	R:R:L399	R:R:L413	5.54	No	Yes	0	9	7
204	R:R:L409	R:R:T403	7.37	No	No	0	3	2
205	R:R:G410	R:R:T403	3.64	No	No	8	3	2
206	R:R:L413	R:R:T403	4.42	Yes	No	8	7	2
207	R:R:P408	R:R:T407	3.5	No	No	0	4	7
208	R:R:G410	R:R:L413	3.42	No	Yes	8	3	7
209	R:R:D417	R:R:I421	5.6	No	No	0	8	4
210	R:R:N427	R:R:N431	10.9	No	No	0	9	9
211	R:R:C429	R:R:F430	8.38	No	No	0	9	7
212	R:R:D441	R:R:F442	3.58	No	Yes	4	7	9
213	R:R:D441	R:R:K445	15.21	No	No	4	7	7
214	R:R:F442	R:R:K445	4.96	Yes	No	4	9	7
215	R:R:K444	R:R:Q448	8.14	No	No	0	5	7
216	R:R:I450	R:R:Q451	4.12	No	No	0	4	6
217	R:R:D404	R:R:P405	3.22	No	No	0	4	4
218	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
219	R:R:I450	R:R:S449	3.1	No	No	0	4	9
220	R:R:I59	R:R:V136	3.07	No	No	0	6	7
221	R:R:I353	R:R:V383	3.07	No	No	0	5	8
222	R:R:M414	R:R:S415	3.07	No	No	0	2	5
223	R:R:I395	R:R:T391	3.04	No	No	0	5	6
224	R:R:F433	R:R:G40	3.01	No	No	0	6	9
225	R:R:L30	R:R:S26	3	Yes	No	0	6	8
226	R:R:L30	R:R:S78	3	Yes	No	3	6	8
227	R:R:L30	R:R:S425	3	Yes	No	0	6	8
228	R:R:L75	R:R:S78	3	Yes	No	3	9	8
229	R:R:G173	R:R:R161	3	No	Yes	0	1	8
230	R:R:L401	R:R:V334	2.98	No	No	0	7	4
231	R:R:L387	R:R:V383	2.98	No	No	0	6	8
232	R:R:L75	R:R:T33	2.95	Yes	No	0	9	8
233	R:R:C140	R:R:H63	2.95	No	Yes	0	4	8
234	R:R:L333	R:R:T337	2.95	No	No	0	3	7
235	R:R:L401	R:R:T337	2.95	No	No	0	7	7
236	R:R:I101	R:R:I98	2.94	No	Yes	2	5	8
237	R:R:I101	R:R:I102	2.94	No	Yes	2	5	8
238	R:R:I24	R:R:M27	2.92	No	No	0	7	6
239	R:R:Q372	R:R:V360	2.87	No	Yes	0	5	6
240	R:R:K440	R:R:K444	2.87	No	No	0	7	5
241	R:R:I29	R:R:L423	2.85	No	No	0	7	8
242	R:R:G144	R:R:W147	2.81	No	Yes	0	5	9
243	R:R:M138	R:R:N135	2.8	No	No	0	6	5
244	R:R:L32	R:R:L36	2.77	No	No	0	6	8
245	R:R:L38	R:R:L73	2.77	No	No	0	7	8
246	R:R:L43	R:R:L437	2.77	No	No	0	8	7
247	R:R:L399	R:R:L402	2.77	No	No	0	9	5
248	R:R:A426	R:R:F430	2.77	No	No	0	8	7
249	R:R:L434	R:R:L438	2.77	No	No	0	9	7
250	R:R:A436	R:R:F442	2.77	No	Yes	0	8	9
251	R:R:P17	R:R:W18	2.7	No	No	0	3	1
252	R:R:P22	R:R:W416	2.7	Yes	No	0	4	7
253	R:R:H63	R:R:I59	2.65	Yes	No	0	8	6
254	R:R:F111	R:R:V149	2.62	No	No	0	8	4
255	R:R:R362	R:R:V124	2.62	No	No	0	7	9
256	R:R:A115	R:R:W60	2.59	No	Yes	0	7	8
257	R:R:H133	R:R:N132	2.55	No	No	0	8	8
258	R:R:F125	R:R:K126	2.48	No	No	0	6	6
259	R:R:V47	R:R:W46	2.45	No	No	0	8	6
260	R:R:F93	R:R:L94	2.44	No	Yes	0	4	8
261	R:R:F93	R:R:L97	2.44	No	No	0	4	6
262	R:R:F158	R:R:L97	2.44	No	No	0	8	6
263	R:R:F433	R:R:L437	2.44	No	No	0	6	7
264	R:R:I359	R:R:Y356	2.42	No	Yes	0	9	9
265	R:R:G37	R:R:P39	2.03	No	No	0	9	7
266	R:R:G40	R:R:P39	2.03	No	No	0	9	7
267	R:R:F396	R:R:W416	2	Yes	No	0	4	7
268	R:R:C72	R:R:G37	1.96	No	No	0	8	9
269	R:R:C429	R:R:G37	1.96	No	No	0	9	9
270	R:R:G410	R:R:T407	1.82	No	No	0	3	7
271	R:R:A108	R:R:A150	1.79	No	No	0	9	9
272	R:R:G91	R:R:L94	1.71	No	Yes	0	9	8
273	R:R:C145	R:R:V149	1.71	No	No	0	6	4
274	R:R:C389	R:R:V388	1.71	No	No	0	9	6
275	R:R:G439	R:R:L438	1.71	No	No	0	9	7
276	R:R:A446	R:R:V47	1.7	No	No	0	8	8
277	R:R:A379	R:R:V360	1.7	No	Yes	0	7	6
278	R:R:A48	R:R:T58	1.68	No	No	0	7	8
279	R:R:K126	R:R:P127	1.67	No	No	0	6	9
280	R:R:S349	R:R:V350	1.62	No	No	0	4	4
281	R:R:V378	R:R:V382	1.6	No	No	0	8	8
282	R:R:T375	R:R:V360	1.59	No	Yes	0	7	6
283	R:R:A48	R:R:L62	1.58	No	No	0	7	8
284	R:R:I338	R:R:V334	1.54	No	No	0	6	4
285	R:R:I338	R:R:V398	1.54	No	No	0	6	7
286	L:L:M6	R:R:S400	1.53	Yes	No	0	0	2
287	R:R:M138	R:R:S141	1.53	No	No	0	6	2
288	R:R:L387	R:R:S349	1.5	No	No	0	6	4
289	R:R:L346	R:R:V342	1.49	No	No	0	8	6
290	R:R:Q53	R:R:T55	1.42	No	No	0	6	9
291	R:R:I163	R:R:N170	1.42	No	No	0	6	4
292	R:R:L35	R:R:L36	1.38	No	No	0	6	8
293	R:R:L66	R:R:L70	1.38	No	No	0	4	6
294	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
295	R:R:F361	R:R:V360	1.31	No	Yes	0	4	6
296	R:R:V159	R:R:Y160	1.26	No	Yes	0	4	8
297	R:R:K440	R:R:R443	1.24	No	No	0	7	9
298	R:R:V23	R:R:W18	1.23	No	No	0	4	1
299	R:R:R443	R:R:R447	1.07	No	No	0	9	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M6	6.125	4	0	0
2	L:L:L8	6.085	4	2	0
3	L:L:R10	9.41	6	1	0
4	R:R:P22	6.6575	4	0	4
5	R:R:L30	4.10167	6	3	6
6	R:R:W60	5.61286	7	0	8
7	R:R:H63	6.57	4	0	8
8	R:R:L64	4.66	4	1	9
9	R:R:D68	6.942	5	0	9
10	R:R:L75	4.39833	6	3	9
11	R:R:W88	7.3	5	2	9
12	R:R:L94	4.53	4	2	8
13	R:R:I98	7.07833	6	2	8
14	R:R:I102	5.62	4	2	8
15	R:R:F107	7.53	4	1	8
16	R:R:L113	5.396	5	1	8
17	R:R:I116	4.2725	4	1	9
18	R:R:R134	7.082	5	7	9
19	R:R:W147	4.825	4	0	9
20	R:R:M153	5.505	4	0	8
21	R:R:Y160	6.17	5	6	8
22	R:R:R161	9.2425	4	0	8
23	R:R:R171	8.532	5	5	1
24	R:R:Y174	12.7025	4	6	7
25	R:R:F345	6.994	5	1	9
26	R:R:P348	4.8525	4	0	9
27	R:R:M352	6.2775	4	1	8
28	R:R:Y356	4.5975	8	1	9
29	R:R:V360	2.804	5	0	6
30	R:R:F386	6.688	5	1	9
31	R:R:W390	6.6825	8	1	9
32	R:R:Y393	8.582	5	1	9
33	R:R:F396	5.96	4	0	4
34	R:R:L413	4.8675	4	8	7
35	R:R:Y435	5.32167	6	1	9
36	R:R:F442	5.562	5	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E162	R:R:R92	12.3983	15.12	No	No	0	5	1
2	R:R:K96	R:R:R92	15.4689	7.43	No	No	0	8	1
3	R:R:F158	R:R:K96	18.5228	16.13	No	No	0	8	8
4	R:R:F158	R:R:S100	21.029	5.28	No	No	0	8	8
5	R:R:S100	R:R:V157	23.527	3.23	No	No	0	8	9
6	R:R:R161	R:R:V157	26.1494	3.92	Yes	No	0	8	9
7	R:R:P99	R:R:R161	31.2033	11.53	No	Yes	0	8	8
8	L:L:L8	R:R:P99	14.3402	4.93	Yes	No	2	0	8
9	L:L:L8	R:R:H81	25.0622	5.14	Yes	No	0	0	7
10	R:R:H81	R:R:R171	22.9958	3.39	No	Yes	0	7	1
11	R:R:R161	R:R:Y174	47.4357	18.52	Yes	Yes	0	8	7
12	L:L:M6	R:R:Y174	68.473	8.38	Yes	Yes	0	0	7
13	L:L:M6	L:L:R10	72.2158	6.2	Yes	Yes	0	0	0
14	R:R:I98	R:R:P99	16.9627	6.77	Yes	No	2	8	8
15	R:R:L94	R:R:W88	10.6639	3.42	Yes	Yes	2	8	9
16	R:R:I98	R:R:W88	32.0249	7.05	Yes	Yes	2	8	9
17	L:L:L8	R:R:I102	21.2531	4.28	Yes	Yes	2	0	8
18	R:R:I102	R:R:I98	28.1992	4.42	Yes	Yes	2	8	8
19	L:L:R10	R:R:Y393	95.9917	13.38	Yes	Yes	1	0	9
20	L:L:R10	R:R:D417	83.668	10.72	Yes	No	0	0	8
21	L:L:R10	R:R:R340	13.195	5.33	Yes	No	0	0	9
22	R:R:D417	R:R:F396	82.473	5.97	No	Yes	0	8	4
23	R:R:F396	R:R:W416	93.0042	2	Yes	No	0	4	7
24	R:R:P22	R:R:W416	90.4315	2.7	Yes	No	0	4	7
25	R:R:E20	R:R:P22	79.9751	12.58	No	Yes	0	4	4
26	R:R:E20	R:R:V23	77.3195	5.7	No	No	0	4	4
27	R:R:L82	R:R:V23	66.8465	7.45	No	No	0	7	4
28	R:R:H418	R:R:L82	58.5726	5.14	No	No	0	4	7
29	R:R:H418	R:R:S26	55.7842	4.18	No	No	0	4	8
30	R:R:L30	R:R:S26	52.9793	3	Yes	No	0	6	8
31	R:R:A422	R:R:L30	15.3444	3.15	No	Yes	0	8	6
32	R:R:A422	R:R:I29	12.3071	3.25	No	No	0	8	7
33	R:R:L30	R:R:L75	26.8382	6.92	Yes	Yes	3	6	9
34	R:R:F34	R:R:L75	17.9751	6.09	No	Yes	3	7	9
35	R:R:F34	R:R:L38	15.0041	10.96	No	No	0	7	7
36	R:R:I102	R:R:S74	50.6971	10.84	Yes	No	0	8	9
37	R:R:N105	R:R:S74	52.1079	4.47	No	No	0	9	9
38	R:R:C71	R:R:N105	56.5394	9.45	No	No	0	8	9
39	R:R:C71	R:R:S428	38.1909	6.89	No	No	0	8	9
40	R:R:D68	R:R:S428	37.527	4.42	Yes	No	0	9	9
41	R:R:D68	R:R:N41	64.6307	6.73	Yes	No	0	9	9
42	R:R:N41	R:R:P432	61.9917	11.4	No	No	0	9	9
43	R:R:G40	R:R:P432	54.2324	4.06	No	No	0	9	9
44	R:R:G40	R:R:P39	43.3112	2.03	No	No	0	9	7
45	R:R:G37	R:R:P39	40.5394	2.03	No	No	0	9	7
46	R:R:C429	R:R:G37	34.9461	1.96	No	No	0	9	9
47	R:R:W390	R:R:Y393	88.7386	7.72	Yes	Yes	1	9	9
48	R:R:N427	R:R:W390	27.5353	7.91	No	Yes	0	9	9
49	R:R:N427	R:R:N431	26.3403	10.9	No	No	0	9	9
50	R:R:D68	R:R:N431	31.0373	10.77	Yes	No	0	9	9
51	R:R:L38	R:R:L73	11.9668	2.77	No	No	0	7	8
52	R:R:F386	R:R:W390	80.3071	8.02	Yes	Yes	1	9	9
53	R:R:F386	R:R:L113	76.6058	4.87	Yes	Yes	1	9	8
54	R:R:L113	R:R:Y435	68.1079	8.21	Yes	Yes	1	8	9
55	R:R:I116	R:R:Y435	100	6.04	Yes	Yes	1	9	9
56	R:R:F61	R:R:I116	50.1079	3.77	No	Yes	0	8	9
57	R:R:A436	R:R:F61	47.7593	5.55	No	No	0	8	8
58	R:R:A436	R:R:F442	45.3112	2.77	No	Yes	0	8	9
59	R:R:F442	R:R:V47	21.7759	6.55	Yes	No	0	9	8
60	R:R:V47	R:R:W46	16.6224	2.45	No	No	0	8	6
61	R:R:S449	R:R:W46	11.1369	6.18	No	No	0	9	6
62	R:R:F442	R:R:M52	16.5726	9.95	Yes	No	4	9	9
63	R:R:M52	R:R:T58	13.9336	9.03	No	No	0	9	8
64	R:R:I116	R:R:W60	68.8548	3.52	Yes	Yes	0	9	8
65	R:R:V56	R:R:W60	10.7386	3.68	No	Yes	0	8	8
66	R:R:D119	R:R:W60	13.2531	14.52	No	Yes	0	9	8
67	R:R:I142	R:R:W60	13.6266	5.87	No	Yes	0	5	8
68	R:R:C143	R:R:W60	27.3776	3.92	No	Yes	0	8	8
69	R:R:C143	R:R:H63	24.7137	13.27	No	Yes	0	8	8
70	R:R:H63	R:R:W147	13.8921	7.41	Yes	Yes	0	8	9
71	R:R:L113	R:R:L64	10.5311	5.54	Yes	Yes	1	8	9
72	R:R:M106	R:R:W390	24.805	4.65	No	Yes	0	9	9
73	R:R:F107	R:R:M153	21.7842	4.98	Yes	Yes	0	8	8
74	R:R:P348	R:R:V110	14.8299	3.53	Yes	No	0	9	9
75	R:R:F111	R:R:M153	13.1369	7.46	No	Yes	0	8	8
76	R:R:F386	R:R:M352	55.1867	9.95	Yes	Yes	1	9	8
77	R:R:M352	R:R:Y356	31.7012	4.79	Yes	Yes	1	8	9
78	R:R:R120	R:R:Y356	13.7593	5.14	No	Yes	1	9	9
79	R:R:M352	R:R:S117	31.112	6.13	Yes	No	1	8	9
80	R:R:C355	R:R:S117	45.7676	6.89	No	No	0	9	9
81	R:R:C121	R:R:C355	42.6058	5.46	No	No	0	9	9
82	R:R:C121	R:R:F358	39.4274	4.19	No	No	0	9	6
83	R:R:F125	R:R:F358	29.7842	16.08	No	No	0	6	6
84	R:R:F125	R:R:K126	26.5477	2.48	No	No	0	6	6
85	R:R:K126	R:R:W129	16.7137	9.28	No	No	0	6	6
86	R:R:H133	R:R:W129	10.0747	12.7	No	No	0	8	6
87	R:R:I142	R:R:M138	11.1452	4.37	No	No	0	5	6
88	R:R:Y160	R:R:Y174	18.249	16.88	Yes	Yes	6	8	7
89	R:R:L333	R:R:Y174	13.2946	7.03	No	Yes	6	3	7
90	R:R:F345	R:R:T391	41.8672	3.89	Yes	No	0	9	6
91	R:R:A379	R:R:Y356	28.6722	4	No	Yes	0	7	9
92	R:R:V383	R:R:Y356	15.8589	5.05	No	Yes	0	8	9
93	R:R:A379	R:R:V360	25.5519	1.7	No	Yes	0	7	6
94	R:R:C429	R:R:F430	23.5602	8.38	No	No	0	9	7
95	R:R:F430	R:R:V385	17.7676	3.93	No	No	0	7	7
96	R:R:L434	R:R:V385	14.8382	4.47	No	No	0	9	7
97	R:R:C420	R:R:F396	35.5851	9.78	No	Yes	0	6	4
98	R:R:C420	R:R:P392	36.2656	3.77	No	No	0	6	9
99	R:R:F396	R:R:L413	24.3568	6.09	Yes	Yes	0	4	7
100	R:R:L333	R:R:T337	11.61	2.95	No	No	0	3	7
101	R:R:D68	R:R:L64	46.7552	5.43	Yes	Yes	0	9	9
102	R:R:L64	R:R:Y435	39.2116	3.52	Yes	Yes	1	9	9
103	R:R:C71	R:R:M106	25.2116	4.86	No	No	0	8	9
104	R:R:L113	R:R:N431	11.2448	4.12	Yes	No	0	8	9
105	R:R:F107	R:R:W390	11.4689	5.01	Yes	Yes	1	8	9
106	R:R:Y356	R:R:Y435	24.8465	3.97	Yes	Yes	1	9	9
107	R:R:P392	R:R:T391	37.4191	5.25	No	No	0	9	6
108	R:R:F345	R:R:F386	44.249	5.36	Yes	Yes	1	9	9
109	R:R:S117	R:R:Y356	17.7925	6.36	No	Yes	1	9	9
110	R:R:I116	R:R:R120	12.6473	3.76	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F3	R:R:E162	3.5	0	No	No	0	5	0	1
L:L:F3	R:R:F164	17.15	0	No	No	0	3	0	1
L:L:K4	R:R:P405	13.38	0	No	No	0	4	0	1
L:L:P5	R:R:T166	10.49	5	No	No	0	1	0	1
L:L:P5	R:R:R171	12.97	5	No	Yes	0	1	0	1
L:L:M6	R:R:Y174	8.38	0	Yes	Yes	0	7	0	1
L:L:L8	R:R:H81	5.14	2	Yes	No	0	7	0	1
L:L:L8	R:R:I98	9.99	2	Yes	Yes	0	8	0	1
L:L:L8	R:R:P99	4.93	2	Yes	No	0	8	0	1
L:L:L8	R:R:I102	4.28	2	Yes	Yes	0	8	0	1
L:L:?9	R:R:Y393	3.58	1	No	Yes	0	9	0	1
L:L:?9	R:R:I421	11.61	1	No	No	0	4	0	1
L:L:R10	R:R:R340	5.33	1	Yes	No	0	9	0	1
L:L:R10	R:R:Y393	13.38	1	Yes	Yes	0	9	0	1
L:L:R10	R:R:G397	6	1	Yes	No	0	8	0	1
L:L:R10	R:R:D417	10.72	1	Yes	No	0	8	0	1
R:R:I102	R:R:S74	10.84	2	Yes	No	8	9	1	2
R:R:F77	R:R:I98	11.3	0	No	Yes	8	8	2	1
R:R:H81	R:R:R171	3.39	0	No	Yes	7	1	1	1
R:R:G86	R:R:R171	7.51	0	No	Yes	7	1	2	1
R:R:I98	R:R:W88	7.05	2	Yes	Yes	8	9	1	2
R:R:E162	R:R:R92	15.12	0	No	No	5	1	1	2
R:R:I98	R:R:P99	6.77	2	Yes	No	8	8	1	1
R:R:I102	R:R:I98	4.42	2	Yes	Yes	8	8	1	1
R:R:P99	R:R:R161	11.53	2	No	Yes	8	8	1	2
R:R:R340	R:R:V103	7.85	0	No	No	9	5	1	2
R:R:F107	R:R:R340	14.97	1	Yes	No	8	9	2	1
R:R:F107	R:R:W390	5.01	1	Yes	Yes	8	9	2	2
R:R:F107	R:R:Y393	5.16	1	Yes	Yes	8	9	2	1
R:R:Y160	R:R:Y174	16.88	6	Yes	Yes	8	7	2	1
R:R:L333	R:R:Y160	3.52	6	No	Yes	3	8	2	2
R:R:R161	R:R:Y174	18.52	0	Yes	Yes	8	7	2	1
R:R:F164	R:R:T165	6.49	0	No	No	3	4	1	2
R:R:R171	R:R:T166	11.64	5	Yes	No	1	1	1	1
R:R:D167	R:R:R171	7.15	0	No	Yes	3	1	2	1
R:R:L333	R:R:Y174	7.03	6	No	Yes	3	7	2	1
R:R:W390	R:R:Y393	7.72	1	Yes	Yes	9	9	2	1
R:R:H394	R:R:Y393	13.07	0	No	Yes	9	9	2	1
R:R:D417	R:R:F396	5.97	0	No	Yes	8	4	1	2
R:R:D417	R:R:I421	5.6	0	No	No	8	4	1	1
R:R:D404	R:R:P405	3.22	0	No	No	4	4	2	1
R:R:I101	R:R:I98	2.94	2	No	Yes	5	8	2	1
R:R:I101	R:R:I102	2.94	2	No	Yes	5	8	2	1
L:L:M6	R:R:S400	1.53	0	Yes	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8I9A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	262
Number of Links	299
Number of Hubs	36
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	45208
Length Of Smallest Path	3
Average Path Length	13.5179
Length of Longest Path	34
Minimum Path Strength	1.155
Average Path Strength	6.36189
Maximum Path Strength	17.7
Minimum Path Correlation	0.7
Average Path Correlation	0.920249
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.086
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7835
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8I9A_nogp_Chain_R P W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

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