psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F3	R:R:E162	3.5	No	No	0	0	5
2	L:L:F3	R:R:F164	17.15	No	No	0	0	3
3	L:L:K4	L:L:P5	5.02	No	No	0	0	0
4	L:L:K4	R:R:P405	13.38	No	No	0	0	4
5	L:L:P5	R:R:T166	10.49	No	No	5	0	1
6	L:L:P5	R:R:R171	12.97	No	Yes	5	0	1
7	L:L:M6	L:L:P7	8.39	Yes	No	0	0	0
8	L:L:M6	L:L:R10	6.2	Yes	Yes	0	0	0
9	L:L:M6	R:R:Y174	8.38	Yes	Yes	0	0	7
10	L:L:L8	R:R:H81	5.14	Yes	No	0	0	7
11	L:L:L8	R:R:I98	9.99	Yes	Yes	2	0	8
12	L:L:L8	R:R:P99	4.93	Yes	No	2	0	8
13	L:L:L8	R:R:I102	4.28	Yes	Yes	2	0	8
14	L:L:?9	L:L:R10	14.83	No	Yes	1	0	0
15	L:L:?9	R:R:Y393	3.58	No	Yes	1	0	9
16	L:L:?9	R:R:I421	11.61	No	No	0	0	4
17	L:L:R10	R:R:R340	5.33	Yes	No	0	0	9
18	L:L:R10	R:R:Y393	13.38	Yes	Yes	1	0	9
19	L:L:R10	R:R:G397	6	Yes	No	0	0	8
20	L:L:R10	R:R:D417	10.72	Yes	No	0	0	8
21	R:R:Q85	R:R:W18	13.14	No	No	0	5	1
22	R:R:E20	R:R:P22	12.58	No	Yes	0	4	4
23	R:R:E20	R:R:V23	5.7	No	No	0	4	4
24	R:R:P21	R:R:P22	7.79	No	Yes	0	6	4
25	R:R:P22	R:R:S415	3.56	Yes	No	0	4	5
26	R:R:L82	R:R:V23	7.45	No	No	0	7	4
27	R:R:I29	R:R:L25	4.28	No	No	0	7	5
28	R:R:L25	R:R:V419	4.47	No	No	0	5	5
29	R:R:H418	R:R:S26	4.18	No	No	0	4	8
30	R:R:L82	R:R:M27	11.31	No	No	0	7	6
31	R:R:A422	R:R:I29	3.25	No	No	0	8	7
32	R:R:L30	R:R:L75	6.92	Yes	Yes	3	6	9
33	R:R:L30	R:R:L79	5.54	Yes	No	3	6	6
34	R:R:F34	R:R:L38	10.96	No	No	0	7	7
35	R:R:F34	R:R:L75	6.09	No	Yes	3	7	9
36	R:R:F34	R:R:P76	10.11	No	No	3	7	9
37	R:R:C429	R:R:L36	4.76	No	No	0	9	8
38	R:R:G40	R:R:P432	4.06	No	No	0	9	9
39	R:R:D68	R:R:N41	6.73	Yes	No	0	9	9
40	R:R:N41	R:R:P432	11.4	No	No	0	9	9
41	R:R:G42	R:R:L45	3.42	No	No	0	6	8
42	R:R:T65	R:R:V44	6.35	No	No	0	9	9
43	R:R:P432	R:R:V44	3.53	No	No	0	9	9
44	R:R:L45	R:R:L69	4.15	No	No	0	8	7
45	R:R:L50	R:R:W46	6.83	No	No	0	4	6
46	R:R:S449	R:R:W46	6.18	No	No	0	9	6
47	R:R:F442	R:R:V47	6.55	Yes	No	0	9	8
48	R:R:K51	R:R:S449	7.65	No	No	0	9	9
49	R:R:M52	R:R:T58	9.03	No	No	0	9	8
50	R:R:F442	R:R:M52	9.95	Yes	No	4	9	9
51	R:R:K445	R:R:M52	8.64	No	No	4	7	9
52	R:R:T55	R:R:T58	6.28	No	No	0	9	8
53	R:R:V56	R:R:W60	3.68	No	Yes	0	8	8
54	R:R:R134	R:R:V56	7.85	Yes	No	0	9	8
55	R:R:N57	R:R:R134	3.62	No	Yes	0	8	9
56	R:R:I116	R:R:W60	3.52	Yes	Yes	0	9	8
57	R:R:D119	R:R:W60	14.52	No	Yes	0	9	8
58	R:R:A139	R:R:W60	5.19	No	Yes	0	7	8
59	R:R:I142	R:R:W60	5.87	No	Yes	0	5	8
60	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
61	R:R:F61	R:R:I116	3.77	No	Yes	0	8	9
62	R:R:A436	R:R:F61	5.55	No	No	0	8	8
63	R:R:C143	R:R:H63	13.27	No	Yes	0	8	8
64	R:R:H63	R:R:W147	7.41	Yes	Yes	0	8	9
65	R:R:D68	R:R:L64	5.43	Yes	Yes	0	9	9
66	R:R:L112	R:R:L64	4.15	No	Yes	0	9	9
67	R:R:L113	R:R:L64	5.54	Yes	Yes	1	8	9
68	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
69	R:R:A67	R:R:W147	3.89	No	Yes	0	9	9
70	R:R:D68	R:R:S109	7.36	Yes	No	0	9	9
71	R:R:D68	R:R:S428	4.42	Yes	No	0	9	9
72	R:R:D68	R:R:N431	10.77	Yes	No	0	9	9
73	R:R:L69	R:R:L73	6.92	No	No	0	7	8
74	R:R:L70	R:R:N105	6.87	No	No	0	6	9
75	R:R:C71	R:R:N105	9.45	No	No	0	8	9
76	R:R:C71	R:R:M106	4.86	No	No	0	8	9
77	R:R:C71	R:R:S428	6.89	No	No	0	8	9
78	R:R:I102	R:R:S74	10.84	Yes	No	0	8	9
79	R:R:N105	R:R:S74	4.47	No	No	0	9	9
80	R:R:L75	R:R:P76	3.28	Yes	No	3	9	9
81	R:R:L75	R:R:L79	4.15	Yes	No	3	9	6
82	R:R:F77	R:R:I98	11.3	No	Yes	0	8	8
83	R:R:H81	R:R:R171	3.39	No	Yes	0	7	1
84	R:R:H418	R:R:L82	5.14	No	No	0	4	7
85	R:R:L84	R:R:Q87	5.32	No	No	0	8	6
86	R:R:L84	R:R:P89	3.28	No	No	0	8	8
87	R:R:G86	R:R:R171	7.51	No	Yes	0	7	1
88	R:R:H169	R:R:Q87	18.54	No	No	0	3	6
89	R:R:P89	R:R:W88	9.46	No	Yes	2	8	9
90	R:R:W88	R:R:Y90	4.82	Yes	No	2	9	7
91	R:R:L94	R:R:W88	3.42	Yes	Yes	2	8	9
92	R:R:C95	R:R:W88	11.75	No	Yes	0	9	9
93	R:R:I98	R:R:W88	7.05	Yes	Yes	2	8	9
94	R:R:P89	R:R:Y90	15.3	No	No	2	8	7
95	R:R:L94	R:R:Y90	10.55	Yes	No	2	8	7
96	R:R:K96	R:R:R92	7.43	No	No	0	8	1
97	R:R:E162	R:R:R92	15.12	No	No	0	5	1
98	R:R:C172	R:R:C95	7.28	No	No	0	8	9
99	R:R:F158	R:R:K96	16.13	No	No	0	8	8
100	R:R:I98	R:R:P99	6.77	Yes	No	2	8	8
101	R:R:I102	R:R:I98	4.42	Yes	Yes	2	8	8
102	R:R:P99	R:R:R161	11.53	No	Yes	0	8	8
103	R:R:S100	R:R:V157	3.23	No	No	0	8	9
104	R:R:F158	R:R:S100	5.28	No	No	0	8	8
105	R:R:M106	R:R:V103	4.56	No	No	0	9	5
106	R:R:C154	R:R:V103	3.42	No	No	0	8	5
107	R:R:R340	R:R:V103	7.85	No	No	0	9	5
108	R:R:C154	R:R:L104	4.76	No	No	0	8	8
109	R:R:M106	R:R:W390	4.65	No	Yes	0	9	9
110	R:R:F107	R:R:M153	4.98	Yes	Yes	0	8	8
111	R:R:F107	R:R:R340	14.97	Yes	No	0	8	9
112	R:R:F107	R:R:W390	5.01	Yes	Yes	1	8	9
113	R:R:F107	R:R:Y393	5.16	Yes	Yes	1	8	9
114	R:R:A108	R:R:W147	5.19	No	Yes	0	9	9
115	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
116	R:R:F386	R:R:V110	5.24	Yes	No	1	9	9
117	R:R:V110	R:R:W390	7.36	No	Yes	1	9	9
118	R:R:F111	R:R:I146	3.77	No	No	0	8	8
119	R:R:F111	R:R:M153	7.46	No	Yes	0	8	8
120	R:R:L113	R:R:M352	4.24	Yes	Yes	1	8	8
121	R:R:F386	R:R:L113	4.87	Yes	Yes	1	9	8
122	R:R:L113	R:R:N431	4.12	Yes	No	0	8	9
123	R:R:L113	R:R:Y435	8.21	Yes	Yes	1	8	9
124	R:R:P348	R:R:T114	5.25	Yes	No	0	9	8
125	R:R:I351	R:R:T114	4.56	No	No	0	6	8
126	R:R:I116	R:R:R120	3.76	Yes	No	1	9	9
127	R:R:I116	R:R:Y435	6.04	Yes	Yes	1	9	9
128	R:R:M352	R:R:S117	6.13	Yes	No	1	8	9
129	R:R:C355	R:R:S117	6.89	No	No	0	9	9
130	R:R:S117	R:R:Y356	6.36	No	Yes	1	9	9
131	R:R:I351	R:R:L118	4.28	No	No	0	6	8
132	R:R:D119	R:R:V123	4.38	No	No	7	9	5
133	R:R:D119	R:R:R134	11.91	No	Yes	7	9	9
134	R:R:R120	R:R:Y356	5.14	No	Yes	1	9	9
135	R:R:R120	R:R:Y435	5.14	No	Yes	1	9	9
136	R:R:C121	R:R:C355	5.46	No	No	0	9	9
137	R:R:C121	R:R:F358	4.19	No	No	0	9	6
138	R:R:L122	R:R:W129	4.56	No	No	0	7	6
139	R:R:R134	R:R:V123	7.85	Yes	No	7	9	5
140	R:R:F125	R:R:F358	16.08	No	No	0	6	6
141	R:R:K126	R:R:W129	9.28	No	No	0	6	6
142	R:R:I128	R:R:P127	5.08	No	No	0	7	9
143	R:R:H133	R:R:W129	12.7	No	No	0	8	6
144	R:R:C130	R:R:R134	4.18	No	Yes	0	7	9
145	R:R:G137	R:R:N135	3.39	No	No	0	5	5
146	R:R:I142	R:R:M138	4.37	No	No	0	5	6
147	R:R:F151	R:R:I155	3.77	No	No	0	5	5
148	R:R:M153	R:R:V343	6.09	Yes	No	0	8	4
149	R:R:G344	R:R:M153	3.49	No	Yes	0	9	8
150	R:R:I155	R:R:P156	3.39	No	No	0	5	9
151	R:R:I336	R:R:P156	6.77	No	No	0	7	9
152	R:R:R161	R:R:V157	3.92	Yes	No	0	8	9
153	R:R:Y160	R:R:Y174	16.88	Yes	Yes	6	8	7
154	R:R:P332	R:R:Y160	5.56	No	Yes	0	4	8
155	R:R:L333	R:R:Y160	3.52	No	Yes	6	3	8
156	R:R:I336	R:R:Y160	3.63	No	Yes	0	7	8
157	R:R:R161	R:R:Y174	18.52	Yes	Yes	0	8	7
158	R:R:C172	R:R:I163	4.91	No	No	0	8	6
159	R:R:F164	R:R:T165	6.49	No	No	0	3	4
160	R:R:R171	R:R:T166	11.64	Yes	No	5	1	1
161	R:R:D167	R:R:N168	5.39	No	No	0	3	5
162	R:R:D167	R:R:R171	7.15	No	Yes	0	3	1
163	R:R:H169	R:R:N168	8.93	No	No	0	3	5
164	R:R:L333	R:R:Y174	7.03	No	Yes	6	3	7
165	R:R:P332	R:R:T331	3.5	No	No	0	4	4
166	R:R:L341	R:R:L346	4.15	No	No	0	6	8
167	R:R:H394	R:R:L341	12.86	No	No	0	9	6
168	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
169	R:R:F345	R:R:L346	4.87	Yes	No	0	9	8
170	R:R:F345	R:R:F386	5.36	Yes	Yes	1	9	9
171	R:R:F345	R:R:W390	5.01	Yes	Yes	1	9	9
172	R:R:F345	R:R:T391	3.89	Yes	No	0	9	6
173	R:R:F345	R:R:H394	15.84	Yes	No	0	9	9
174	R:R:L347	R:R:P348	6.57	No	Yes	0	7	9
175	R:R:M352	R:R:Y356	4.79	Yes	Yes	1	8	9
176	R:R:F386	R:R:M352	9.95	Yes	Yes	1	9	8
177	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
178	R:R:V382	R:R:Y356	5.05	No	Yes	1	8	9
179	R:R:V383	R:R:Y356	5.05	No	Yes	0	8	9
180	R:R:Y356	R:R:Y435	3.97	Yes	Yes	1	9	9
181	R:R:F361	R:R:S357	6.61	No	No	0	4	6
182	R:R:F358	R:R:R362	6.41	No	No	0	6	7
183	R:R:F376	R:R:V360	6.55	No	Yes	0	4	6
184	R:R:M363	R:R:T375	12.04	No	No	0	7	7
185	R:R:K374	R:R:V378	6.07	No	No	0	9	8
186	R:R:F376	R:R:V380	6.55	No	No	0	4	3
187	R:R:R377	R:R:V381	3.92	No	No	0	5	7
188	R:R:L434	R:R:V381	5.96	No	No	0	9	7
189	R:R:V382	R:R:Y435	5.05	No	Yes	1	8	9
190	R:R:F430	R:R:V385	3.93	No	No	0	7	7
191	R:R:L434	R:R:V385	4.47	No	No	0	9	7
192	R:R:F386	R:R:W390	8.02	Yes	Yes	1	9	9
193	R:R:C389	R:R:N427	9.45	No	No	0	9	9
194	R:R:W390	R:R:Y393	7.72	Yes	Yes	1	9	9
195	R:R:A424	R:R:W390	7.78	No	Yes	0	9	9
196	R:R:N427	R:R:W390	7.91	No	Yes	0	9	9
197	R:R:P392	R:R:T391	5.25	No	No	0	9	6
198	R:R:C420	R:R:P392	3.77	No	No	0	6	9
199	R:R:H394	R:R:Y393	13.07	No	Yes	0	9	9
200	R:R:F396	R:R:L413	6.09	Yes	Yes	0	4	7
201	R:R:D417	R:R:F396	5.97	No	Yes	0	8	4
202	R:R:C420	R:R:F396	9.78	No	Yes	0	6	4
203	R:R:L399	R:R:L413	5.54	No	Yes	0	9	7
204	R:R:L409	R:R:T403	7.37	No	No	0	3	2
205	R:R:G410	R:R:T403	3.64	No	No	8	3	2
206	R:R:L413	R:R:T403	4.42	Yes	No	8	7	2
207	R:R:P408	R:R:T407	3.5	No	No	0	4	7
208	R:R:G410	R:R:L413	3.42	No	Yes	8	3	7
209	R:R:D417	R:R:I421	5.6	No	No	0	8	4
210	R:R:N427	R:R:N431	10.9	No	No	0	9	9
211	R:R:C429	R:R:F430	8.38	No	No	0	9	7
212	R:R:D441	R:R:F442	3.58	No	Yes	4	7	9
213	R:R:D441	R:R:K445	15.21	No	No	4	7	7
214	R:R:F442	R:R:K445	4.96	Yes	No	4	9	7
215	R:R:K444	R:R:Q448	8.14	No	No	0	5	7
216	R:R:I450	R:R:Q451	4.12	No	No	0	4	6
217	R:R:D404	R:R:P405	3.22	No	No	0	4	4
218	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
219	R:R:I450	R:R:S449	3.1	No	No	0	4	9
220	R:R:I59	R:R:V136	3.07	No	No	0	6	7
221	R:R:I353	R:R:V383	3.07	No	No	0	5	8
222	R:R:M414	R:R:S415	3.07	No	No	0	2	5
223	R:R:I395	R:R:T391	3.04	No	No	0	5	6
224	R:R:F433	R:R:G40	3.01	No	No	0	6	9
225	R:R:L30	R:R:S26	3	Yes	No	0	6	8
226	R:R:L30	R:R:S78	3	Yes	No	3	6	8
227	R:R:L30	R:R:S425	3	Yes	No	0	6	8
228	R:R:L75	R:R:S78	3	Yes	No	3	9	8
229	R:R:G173	R:R:R161	3	No	Yes	0	1	8
230	R:R:L401	R:R:V334	2.98	No	No	0	7	4
231	R:R:L387	R:R:V383	2.98	No	No	0	6	8
232	R:R:L75	R:R:T33	2.95	Yes	No	0	9	8
233	R:R:C140	R:R:H63	2.95	No	Yes	0	4	8
234	R:R:L333	R:R:T337	2.95	No	No	0	3	7
235	R:R:L401	R:R:T337	2.95	No	No	0	7	7
236	R:R:I101	R:R:I98	2.94	No	Yes	2	5	8
237	R:R:I101	R:R:I102	2.94	No	Yes	2	5	8
238	R:R:I24	R:R:M27	2.92	No	No	0	7	6
239	R:R:Q372	R:R:V360	2.87	No	Yes	0	5	6
240	R:R:K440	R:R:K444	2.87	No	No	0	7	5
241	R:R:I29	R:R:L423	2.85	No	No	0	7	8
242	R:R:G144	R:R:W147	2.81	No	Yes	0	5	9
243	R:R:M138	R:R:N135	2.8	No	No	0	6	5
244	R:R:L32	R:R:L36	2.77	No	No	0	6	8
245	R:R:L38	R:R:L73	2.77	No	No	0	7	8
246	R:R:L43	R:R:L437	2.77	No	No	0	8	7
247	R:R:L399	R:R:L402	2.77	No	No	0	9	5
248	R:R:A426	R:R:F430	2.77	No	No	0	8	7
249	R:R:L434	R:R:L438	2.77	No	No	0	9	7
250	R:R:A436	R:R:F442	2.77	No	Yes	0	8	9
251	R:R:P17	R:R:W18	2.7	No	No	0	3	1
252	R:R:P22	R:R:W416	2.7	Yes	No	0	4	7
253	R:R:H63	R:R:I59	2.65	Yes	No	0	8	6
254	R:R:F111	R:R:V149	2.62	No	No	0	8	4
255	R:R:R362	R:R:V124	2.62	No	No	0	7	9
256	R:R:A115	R:R:W60	2.59	No	Yes	0	7	8
257	R:R:H133	R:R:N132	2.55	No	No	0	8	8
258	R:R:F125	R:R:K126	2.48	No	No	0	6	6
259	R:R:V47	R:R:W46	2.45	No	No	0	8	6
260	R:R:F93	R:R:L94	2.44	No	Yes	0	4	8
261	R:R:F93	R:R:L97	2.44	No	No	0	4	6
262	R:R:F158	R:R:L97	2.44	No	No	0	8	6
263	R:R:F433	R:R:L437	2.44	No	No	0	6	7
264	R:R:I359	R:R:Y356	2.42	No	Yes	0	9	9
265	R:R:G37	R:R:P39	2.03	No	No	0	9	7
266	R:R:G40	R:R:P39	2.03	No	No	0	9	7
267	R:R:F396	R:R:W416	2	Yes	No	0	4	7
268	R:R:C72	R:R:G37	1.96	No	No	0	8	9
269	R:R:C429	R:R:G37	1.96	No	No	0	9	9
270	R:R:G410	R:R:T407	1.82	No	No	0	3	7
271	R:R:A108	R:R:A150	1.79	No	No	0	9	9
272	R:R:G91	R:R:L94	1.71	No	Yes	0	9	8
273	R:R:C145	R:R:V149	1.71	No	No	0	6	4
274	R:R:C389	R:R:V388	1.71	No	No	0	9	6
275	R:R:G439	R:R:L438	1.71	No	No	0	9	7
276	R:R:A446	R:R:V47	1.7	No	No	0	8	8
277	R:R:A379	R:R:V360	1.7	No	Yes	0	7	6
278	R:R:A48	R:R:T58	1.68	No	No	0	7	8
279	R:R:K126	R:R:P127	1.67	No	No	0	6	9
280	R:R:S349	R:R:V350	1.62	No	No	0	4	4
281	R:R:V378	R:R:V382	1.6	No	No	0	8	8
282	R:R:T375	R:R:V360	1.59	No	Yes	0	7	6
283	R:R:A48	R:R:L62	1.58	No	No	0	7	8
284	R:R:I338	R:R:V334	1.54	No	No	0	6	4
285	R:R:I338	R:R:V398	1.54	No	No	0	6	7
286	L:L:M6	R:R:S400	1.53	Yes	No	0	0	2
287	R:R:M138	R:R:S141	1.53	No	No	0	6	2
288	R:R:L387	R:R:S349	1.5	No	No	0	6	4
289	R:R:L346	R:R:V342	1.49	No	No	0	8	6
290	R:R:Q53	R:R:T55	1.42	No	No	0	6	9
291	R:R:I163	R:R:N170	1.42	No	No	0	6	4
292	R:R:L35	R:R:L36	1.38	No	No	0	6	8
293	R:R:L66	R:R:L70	1.38	No	No	0	4	6
294	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
295	R:R:F361	R:R:V360	1.31	No	Yes	0	4	6
296	R:R:V159	R:R:Y160	1.26	No	Yes	0	4	8
297	R:R:K440	R:R:R443	1.24	No	No	0	7	9
298	R:R:V23	R:R:W18	1.23	No	No	0	4	1
299	R:R:R443	R:R:R447	1.07	No	No	0	9	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M6	6.125	4	0	0
2	L:L:L8	6.085	4	2	0
3	L:L:R10	9.41	6	1	0
4	R:R:P22	6.6575	4	0	4
5	R:R:L30	4.10167	6	3	6
6	R:R:W60	5.61286	7	0	8
7	R:R:H63	6.57	4	0	8
8	R:R:L64	4.66	4	1	9
9	R:R:D68	6.942	5	0	9
10	R:R:L75	4.39833	6	3	9
11	R:R:W88	7.3	5	2	9
12	R:R:L94	4.53	4	2	8
13	R:R:I98	7.07833	6	2	8
14	R:R:I102	5.62	4	2	8
15	R:R:F107	7.53	4	1	8
16	R:R:L113	5.396	5	1	8
17	R:R:I116	4.2725	4	1	9
18	R:R:R134	7.082	5	7	9
19	R:R:W147	4.825	4	0	9
20	R:R:M153	5.505	4	0	8
21	R:R:Y160	6.17	5	6	8
22	R:R:R161	9.2425	4	0	8
23	R:R:R171	8.532	5	5	1
24	R:R:Y174	12.7025	4	6	7
25	R:R:F345	6.994	5	1	9
26	R:R:P348	4.8525	4	0	9
27	R:R:M352	6.2775	4	1	8
28	R:R:Y356	4.5975	8	1	9
29	R:R:V360	2.804	5	0	6
30	R:R:F386	6.688	5	1	9
31	R:R:W390	6.6825	8	1	9
32	R:R:Y393	8.582	5	1	9
33	R:R:F396	5.96	4	0	4
34	R:R:L413	4.8675	4	8	7
35	R:R:Y435	5.32167	6	1	9
36	R:R:F442	5.562	5	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E162	R:R:R92	12.3983	15.12	No	No	0	5	1
2	R:R:K96	R:R:R92	15.4689	7.43	No	No	0	8	1
3	R:R:F158	R:R:K96	18.5228	16.13	No	No	0	8	8
4	R:R:F158	R:R:S100	21.029	5.28	No	No	0	8	8
5	R:R:S100	R:R:V157	23.527	3.23	No	No	0	8	9
6	R:R:R161	R:R:V157	26.1494	3.92	Yes	No	0	8	9
7	R:R:P99	R:R:R161	31.2033	11.53	No	Yes	0	8	8
8	L:L:L8	R:R:P99	14.3402	4.93	Yes	No	2	0	8
9	L:L:L8	R:R:H81	25.0622	5.14	Yes	No	0	0	7
10	R:R:H81	R:R:R171	22.9958	3.39	No	Yes	0	7	1
11	R:R:R161	R:R:Y174	47.4357	18.52	Yes	Yes	0	8	7
12	L:L:M6	R:R:Y174	68.473	8.38	Yes	Yes	0	0	7
13	L:L:M6	L:L:R10	72.2158	6.2	Yes	Yes	0	0	0
14	R:R:I98	R:R:P99	16.9627	6.77	Yes	No	2	8	8
15	R:R:L94	R:R:W88	10.6639	3.42	Yes	Yes	2	8	9
16	R:R:I98	R:R:W88	32.0249	7.05	Yes	Yes	2	8	9
17	L:L:L8	R:R:I102	21.2531	4.28	Yes	Yes	2	0	8
18	R:R:I102	R:R:I98	28.1992	4.42	Yes	Yes	2	8	8
19	L:L:R10	R:R:Y393	95.9917	13.38	Yes	Yes	1	0	9
20	L:L:R10	R:R:D417	83.668	10.72	Yes	No	0	0	8
21	L:L:R10	R:R:R340	13.195	5.33	Yes	No	0	0	9
22	R:R:D417	R:R:F396	82.473	5.97	No	Yes	0	8	4
23	R:R:F396	R:R:W416	93.0042	2	Yes	No	0	4	7
24	R:R:P22	R:R:W416	90.4315	2.7	Yes	No	0	4	7
25	R:R:E20	R:R:P22	79.9751	12.58	No	Yes	0	4	4
26	R:R:E20	R:R:V23	77.3195	5.7	No	No	0	4	4
27	R:R:L82	R:R:V23	66.8465	7.45	No	No	0	7	4
28	R:R:H418	R:R:L82	58.5726	5.14	No	No	0	4	7
29	R:R:H418	R:R:S26	55.7842	4.18	No	No	0	4	8
30	R:R:L30	R:R:S26	52.9793	3	Yes	No	0	6	8
31	R:R:A422	R:R:L30	15.3444	3.15	No	Yes	0	8	6
32	R:R:A422	R:R:I29	12.3071	3.25	No	No	0	8	7
33	R:R:L30	R:R:L75	26.8382	6.92	Yes	Yes	3	6	9
34	R:R:F34	R:R:L75	17.9751	6.09	No	Yes	3	7	9
35	R:R:F34	R:R:L38	15.0041	10.96	No	No	0	7	7
36	R:R:I102	R:R:S74	50.6971	10.84	Yes	No	0	8	9
37	R:R:N105	R:R:S74	52.1079	4.47	No	No	0	9	9
38	R:R:C71	R:R:N105	56.5394	9.45	No	No	0	8	9
39	R:R:C71	R:R:S428	38.1909	6.89	No	No	0	8	9
40	R:R:D68	R:R:S428	37.527	4.42	Yes	No	0	9	9
41	R:R:D68	R:R:N41	64.6307	6.73	Yes	No	0	9	9
42	R:R:N41	R:R:P432	61.9917	11.4	No	No	0	9	9
43	R:R:G40	R:R:P432	54.2324	4.06	No	No	0	9	9
44	R:R:G40	R:R:P39	43.3112	2.03	No	No	0	9	7
45	R:R:G37	R:R:P39	40.5394	2.03	No	No	0	9	7
46	R:R:C429	R:R:G37	34.9461	1.96	No	No	0	9	9
47	R:R:W390	R:R:Y393	88.7386	7.72	Yes	Yes	1	9	9
48	R:R:N427	R:R:W390	27.5353	7.91	No	Yes	0	9	9
49	R:R:N427	R:R:N431	26.3403	10.9	No	No	0	9	9
50	R:R:D68	R:R:N431	31.0373	10.77	Yes	No	0	9	9
51	R:R:L38	R:R:L73	11.9668	2.77	No	No	0	7	8
52	R:R:F386	R:R:W390	80.3071	8.02	Yes	Yes	1	9	9
53	R:R:F386	R:R:L113	76.6058	4.87	Yes	Yes	1	9	8
54	R:R:L113	R:R:Y435	68.1079	8.21	Yes	Yes	1	8	9
55	R:R:I116	R:R:Y435	100	6.04	Yes	Yes	1	9	9
56	R:R:F61	R:R:I116	50.1079	3.77	No	Yes	0	8	9
57	R:R:A436	R:R:F61	47.7593	5.55	No	No	0	8	8
58	R:R:A436	R:R:F442	45.3112	2.77	No	Yes	0	8	9
59	R:R:F442	R:R:V47	21.7759	6.55	Yes	No	0	9	8
60	R:R:V47	R:R:W46	16.6224	2.45	No	No	0	8	6
61	R:R:S449	R:R:W46	11.1369	6.18	No	No	0	9	6
62	R:R:F442	R:R:M52	16.5726	9.95	Yes	No	4	9	9
63	R:R:M52	R:R:T58	13.9336	9.03	No	No	0	9	8
64	R:R:I116	R:R:W60	68.8548	3.52	Yes	Yes	0	9	8
65	R:R:V56	R:R:W60	10.7386	3.68	No	Yes	0	8	8
66	R:R:D119	R:R:W60	13.2531	14.52	No	Yes	0	9	8
67	R:R:I142	R:R:W60	13.6266	5.87	No	Yes	0	5	8
68	R:R:C143	R:R:W60	27.3776	3.92	No	Yes	0	8	8
69	R:R:C143	R:R:H63	24.7137	13.27	No	Yes	0	8	8
70	R:R:H63	R:R:W147	13.8921	7.41	Yes	Yes	0	8	9
71	R:R:L113	R:R:L64	10.5311	5.54	Yes	Yes	1	8	9
72	R:R:M106	R:R:W390	24.805	4.65	No	Yes	0	9	9
73	R:R:F107	R:R:M153	21.7842	4.98	Yes	Yes	0	8	8
74	R:R:P348	R:R:V110	14.8299	3.53	Yes	No	0	9	9
75	R:R:F111	R:R:M153	13.1369	7.46	No	Yes	0	8	8
76	R:R:F386	R:R:M352	55.1867	9.95	Yes	Yes	1	9	8
77	R:R:M352	R:R:Y356	31.7012	4.79	Yes	Yes	1	8	9
78	R:R:R120	R:R:Y356	13.7593	5.14	No	Yes	1	9	9
79	R:R:M352	R:R:S117	31.112	6.13	Yes	No	1	8	9
80	R:R:C355	R:R:S117	45.7676	6.89	No	No	0	9	9
81	R:R:C121	R:R:C355	42.6058	5.46	No	No	0	9	9
82	R:R:C121	R:R:F358	39.4274	4.19	No	No	0	9	6
83	R:R:F125	R:R:F358	29.7842	16.08	No	No	0	6	6
84	R:R:F125	R:R:K126	26.5477	2.48	No	No	0	6	6
85	R:R:K126	R:R:W129	16.7137	9.28	No	No	0	6	6
86	R:R:H133	R:R:W129	10.0747	12.7	No	No	0	8	6
87	R:R:I142	R:R:M138	11.1452	4.37	No	No	0	5	6
88	R:R:Y160	R:R:Y174	18.249	16.88	Yes	Yes	6	8	7
89	R:R:L333	R:R:Y174	13.2946	7.03	No	Yes	6	3	7
90	R:R:F345	R:R:T391	41.8672	3.89	Yes	No	0	9	6
91	R:R:A379	R:R:Y356	28.6722	4	No	Yes	0	7	9
92	R:R:V383	R:R:Y356	15.8589	5.05	No	Yes	0	8	9
93	R:R:A379	R:R:V360	25.5519	1.7	No	Yes	0	7	6
94	R:R:C429	R:R:F430	23.5602	8.38	No	No	0	9	7
95	R:R:F430	R:R:V385	17.7676	3.93	No	No	0	7	7
96	R:R:L434	R:R:V385	14.8382	4.47	No	No	0	9	7
97	R:R:C420	R:R:F396	35.5851	9.78	No	Yes	0	6	4
98	R:R:C420	R:R:P392	36.2656	3.77	No	No	0	6	9
99	R:R:F396	R:R:L413	24.3568	6.09	Yes	Yes	0	4	7
100	R:R:L333	R:R:T337	11.61	2.95	No	No	0	3	7
101	R:R:D68	R:R:L64	46.7552	5.43	Yes	Yes	0	9	9
102	R:R:L64	R:R:Y435	39.2116	3.52	Yes	Yes	1	9	9
103	R:R:C71	R:R:M106	25.2116	4.86	No	No	0	8	9
104	R:R:L113	R:R:N431	11.2448	4.12	Yes	No	0	8	9
105	R:R:F107	R:R:W390	11.4689	5.01	Yes	Yes	1	8	9
106	R:R:Y356	R:R:Y435	24.8465	3.97	Yes	Yes	1	9	9
107	R:R:P392	R:R:T391	37.4191	5.25	No	No	0	9	6
108	R:R:F345	R:R:F386	44.249	5.36	Yes	Yes	1	9	9
109	R:R:S117	R:R:Y356	17.7925	6.36	No	Yes	1	9	9
110	R:R:I116	R:R:R120	12.6473	3.76	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F3	R:R:E162	3.5	0	No	No	0	5	0	1
L:L:F3	R:R:F164	17.15	0	No	No	0	3	0	1
L:L:K4	R:R:P405	13.38	0	No	No	0	4	0	1
L:L:P5	R:R:T166	10.49	5	No	No	0	1	0	1
L:L:P5	R:R:R171	12.97	5	No	Yes	0	1	0	1
L:L:M6	R:R:Y174	8.38	0	Yes	Yes	0	7	0	1
L:L:L8	R:R:H81	5.14	2	Yes	No	0	7	0	1
L:L:L8	R:R:I98	9.99	2	Yes	Yes	0	8	0	1
L:L:L8	R:R:P99	4.93	2	Yes	No	0	8	0	1
L:L:L8	R:R:I102	4.28	2	Yes	Yes	0	8	0	1
L:L:?9	R:R:Y393	3.58	1	No	Yes	0	9	0	1
L:L:?9	R:R:I421	11.61	1	No	No	0	4	0	1
L:L:R10	R:R:R340	5.33	1	Yes	No	0	9	0	1
L:L:R10	R:R:Y393	13.38	1	Yes	Yes	0	9	0	1
L:L:R10	R:R:G397	6	1	Yes	No	0	8	0	1
L:L:R10	R:R:D417	10.72	1	Yes	No	0	8	0	1
R:R:I102	R:R:S74	10.84	2	Yes	No	8	9	1	2
R:R:F77	R:R:I98	11.3	0	No	Yes	8	8	2	1
R:R:H81	R:R:R171	3.39	0	No	Yes	7	1	1	1
R:R:G86	R:R:R171	7.51	0	No	Yes	7	1	2	1
R:R:I98	R:R:W88	7.05	2	Yes	Yes	8	9	1	2
R:R:E162	R:R:R92	15.12	0	No	No	5	1	1	2
R:R:I98	R:R:P99	6.77	2	Yes	No	8	8	1	1
R:R:I102	R:R:I98	4.42	2	Yes	Yes	8	8	1	1
R:R:P99	R:R:R161	11.53	2	No	Yes	8	8	1	2
R:R:R340	R:R:V103	7.85	0	No	No	9	5	1	2
R:R:F107	R:R:R340	14.97	1	Yes	No	8	9	2	1
R:R:F107	R:R:W390	5.01	1	Yes	Yes	8	9	2	2
R:R:F107	R:R:Y393	5.16	1	Yes	Yes	8	9	2	1
R:R:Y160	R:R:Y174	16.88	6	Yes	Yes	8	7	2	1
R:R:L333	R:R:Y160	3.52	6	No	Yes	3	8	2	2
R:R:R161	R:R:Y174	18.52	0	Yes	Yes	8	7	2	1
R:R:F164	R:R:T165	6.49	0	No	No	3	4	1	2
R:R:R171	R:R:T166	11.64	5	Yes	No	1	1	1	1
R:R:D167	R:R:R171	7.15	0	No	Yes	3	1	2	1
R:R:L333	R:R:Y174	7.03	6	No	Yes	3	7	2	1
R:R:W390	R:R:Y393	7.72	1	Yes	Yes	9	9	2	1
R:R:H394	R:R:Y393	13.07	0	No	Yes	9	9	2	1
R:R:D417	R:R:F396	5.97	0	No	Yes	8	4	1	2
R:R:D417	R:R:I421	5.6	0	No	No	8	4	1	1
R:R:D404	R:R:P405	3.22	0	No	No	4	4	2	1
R:R:I101	R:R:I98	2.94	2	No	Yes	5	8	2	1
R:R:I101	R:R:I102	2.94	2	No	Yes	5	8	2	1
L:L:M6	R:R:S400	1.53	0	Yes	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8I9A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	262
Number of Links	299
Number of Hubs	36
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	45208
Length Of Smallest Path	3
Average Path Length	13.5179
Length of Longest Path	34
Minimum Path Strength	1.155
Average Path Strength	6.36189
Maximum Path Strength	17.7
Minimum Path Correlation	0.7
Average Path Correlation	0.920249
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.086
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7835
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • complement component C3a receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • G protein-coupled receptor activity • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • calcium-mediated signaling • circulatory system process • blood circulation • intracellular vesicle • specific granule membrane • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule • azurophil granule • primary lysosome • azurophil granule membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8I9A_nogp_Chain_R P W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Q G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KVP	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-	Go/β1/γ2	2.79	2025-11-26	10.1101/2025.05.26.656101
	9KVP (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-		2.79	2025-11-26	10.1101/2025.05.26.656101
	9KZ2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-	Go/β1/γ2	3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-		3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-	Go/β1/γ2	3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZ8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-		3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZK	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-	Go/β1/γ2	3.54	2025-11-26	10.1101/2025.05.26.656101
	9KZK (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-		3.54	2025-11-26	10.1101/2025.05.26.656101
	9L0H	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-	Go/β1/γ2	3.57	2025-11-26	10.1101/2025.05.26.656101
	9L0H (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-		3.57	2025-11-26	10.1101/2025.05.26.656101
	9UMJ	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-	Go/β1/γ2	3.38	2025-11-26	10.1101/2025.05.26.656101
	9UMJ (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-		3.38	2025-11-26	10.1101/2025.05.26.656101
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWF (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9KV6	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV6 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	3.17	2025-11-26	10.1101/2025.05.26.656101
	9KV8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		3.17	2025-11-26	10.1101/2025.05.26.656101

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