psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P22	R:R:S415	3.56	No	No	0	4	5
2	R:R:P22	R:R:W416	10.81	No	No	0	4	7
3	R:R:S26	R:R:V23	3.23	Yes	No	5	8	4
4	R:R:L82	R:R:V23	4.47	No	No	5	7	4
5	R:R:L25	R:R:V419	5.96	No	No	0	5	5
6	R:R:L82	R:R:S26	3	No	Yes	5	7	8
7	R:R:H418	R:R:S26	2.79	No	Yes	0	4	8
8	R:R:L82	R:R:M27	2.83	No	No	0	7	6
9	R:R:L30	R:R:L79	4.15	Yes	No	0	6	6
10	R:R:L30	R:R:S425	4.5	Yes	No	0	6	8
11	R:R:A426	R:R:T33	5.03	No	No	0	8	8
12	R:R:C429	R:R:T33	5.07	No	No	0	9	8
13	R:R:F34	R:R:L38	3.65	No	No	0	7	7
14	R:R:F34	R:R:L75	9.74	No	No	0	7	9
15	R:R:F34	R:R:P76	8.67	No	No	0	7	9
16	R:R:C429	R:R:G37	3.92	No	No	0	9	9
17	R:R:L38	R:R:L73	2.77	No	No	0	7	8
18	R:R:L69	R:R:N41	2.75	No	Yes	0	7	9
19	R:R:C72	R:R:N41	3.15	No	Yes	0	8	9
20	R:R:N41	R:R:P432	6.52	Yes	No	0	9	9
21	R:R:T65	R:R:V44	6.35	No	No	0	9	9
22	R:R:L454	R:R:V44	2.98	Yes	No	0	8	9
23	R:R:V47	R:R:W46	3.68	Yes	No	0	8	6
24	R:R:K51	R:R:W46	5.8	No	No	0	9	6
25	R:R:I450	R:R:V47	7.68	No	Yes	1	4	8
26	R:R:L454	R:R:V47	11.92	Yes	Yes	1	8	8
27	R:R:E455	R:R:V47	2.85	Yes	Yes	0	9	8
28	R:R:G49	R:R:R54	4.5	No	No	0	7	7
29	R:R:E455	R:R:K51	4.05	Yes	No	0	9	9
30	R:R:E455	R:R:M52	5.41	Yes	No	0	9	9
31	R:R:L62	R:R:R54	3.64	No	No	0	8	7
32	R:R:T55	R:R:V56	3.17	No	No	0	9	8
33	R:R:T55	R:R:T58	3.14	No	No	0	9	8
34	R:R:R134	R:R:V56	7.85	No	No	0	9	8
35	R:R:A139	R:R:V56	3.39	No	No	0	7	8
36	R:R:F61	R:R:N57	3.62	Yes	No	0	8	8
37	R:R:F458	R:R:T58	7.78	Yes	No	0	8	8
38	R:R:H63	R:R:I59	5.3	Yes	No	0	8	6
39	R:R:I116	R:R:W60	4.7	No	No	0	9	8
40	R:R:D119	R:R:W60	8.93	No	No	0	9	8
41	R:R:C143	R:R:W60	3.92	No	No	0	8	8
42	R:R:F61	R:R:I116	3.77	Yes	No	0	8	9
43	R:R:F61	R:R:Y435	9.28	Yes	No	1	8	9
44	R:R:F458	R:R:F61	13.93	Yes	Yes	1	8	8
45	R:R:H63	R:R:L112	2.57	Yes	No	0	8	9
46	R:R:C143	R:R:H63	16.22	No	Yes	0	8	8
47	R:R:H63	R:R:W147	7.41	Yes	Yes	0	8	9
48	R:R:L64	R:R:S109	3	No	No	0	9	9
49	R:R:L112	R:R:L64	2.77	No	No	0	9	9
50	R:R:L113	R:R:L64	2.77	No	No	0	8	9
51	R:R:A67	R:R:W147	2.59	No	Yes	0	9	9
52	R:R:D68	R:R:S428	10.31	No	No	0	9	9
53	R:R:D68	R:R:N431	4.04	No	No	0	9	9
54	R:R:C71	R:R:N105	11.02	No	No	0	8	9
55	R:R:C71	R:R:S428	3.44	No	No	0	8	9
56	R:R:I101	R:R:S74	7.74	Yes	No	0	5	9
57	R:R:L75	R:R:S425	3	No	No	0	9	8
58	R:R:F77	R:R:I98	5.02	No	No	0	8	8
59	R:R:H81	R:R:L94	2.57	No	No	0	7	8
60	R:R:L94	R:R:P89	3.28	No	No	0	8	8
61	R:R:K96	R:R:R92	4.95	No	No	0	8	1
62	R:R:I98	R:R:L94	2.85	No	No	0	8	8
63	R:R:F158	R:R:K96	6.2	No	No	0	8	8
64	R:R:I101	R:R:L97	2.85	Yes	No	0	5	6
65	R:R:I98	R:R:P99	5.08	No	No	0	8	8
66	R:R:C154	R:R:S100	3.44	No	No	0	8	8
67	R:R:S100	R:R:V157	4.85	No	No	0	8	9
68	R:R:I102	R:R:N105	2.83	No	No	0	8	9
69	R:R:F107	R:R:V103	2.62	Yes	No	2	8	5
70	R:R:V103	R:R:V157	4.81	No	No	0	5	9
71	R:R:R340	R:R:V103	6.54	No	No	2	9	5
72	R:R:C154	R:R:L104	4.76	No	No	0	8	8
73	R:R:M106	R:R:W390	10.47	No	Yes	0	9	9
74	R:R:H394	R:R:M106	5.25	No	No	0	9	9
75	R:R:F107	R:R:M153	6.22	Yes	No	2	8	8
76	R:R:F107	R:R:R340	4.28	Yes	No	2	8	9
77	R:R:F107	R:R:V343	2.62	Yes	Yes	2	8	4
78	R:R:F107	R:R:G344	3.01	Yes	No	0	8	9
79	R:R:A108	R:R:W147	3.89	No	Yes	0	9	9
80	R:R:F386	R:R:S109	2.64	Yes	No	0	9	9
81	R:R:F111	R:R:V110	2.62	No	No	0	8	9
82	R:R:P348	R:R:V110	3.53	No	No	0	9	9
83	R:R:F386	R:R:V110	2.62	Yes	No	0	9	9
84	R:R:F111	R:R:V149	5.24	No	No	0	8	4
85	R:R:F111	R:R:V343	2.62	No	Yes	0	8	4
86	R:R:I146	R:R:L112	2.85	No	No	0	8	9
87	R:R:F386	R:R:L113	4.87	Yes	No	0	9	8
88	R:R:P348	R:R:T114	3.5	No	No	0	9	8
89	R:R:I351	R:R:T114	4.56	No	No	0	6	8
90	R:R:M352	R:R:T114	3.01	Yes	No	0	8	8
91	R:R:I116	R:R:R120	3.76	No	No	0	9	9
92	R:R:M352	R:R:S117	7.67	Yes	No	3	8	9
93	R:R:S117	R:R:Y356	11.45	No	Yes	3	9	9
94	R:R:I351	R:R:L118	2.85	No	No	0	6	8
95	R:R:D119	R:R:R134	13.1	No	No	0	9	9
96	R:R:R120	R:R:T375	3.88	No	No	0	9	7
97	R:R:C121	R:R:C355	7.28	No	No	0	9	9
98	R:R:C121	R:R:F358	2.79	No	Yes	0	9	6
99	R:R:C121	R:R:I359	3.27	No	No	0	9	9
100	R:R:F358	R:R:V124	2.62	Yes	No	0	6	9
101	R:R:F125	R:R:W129	4.01	No	No	0	6	6
102	R:R:F125	R:R:F358	4.29	No	Yes	0	6	6
103	R:R:I128	R:R:K126	4.36	No	No	0	7	6
104	R:R:K126	R:R:W129	6.96	No	No	0	6	6
105	R:R:H133	R:R:M138	2.63	No	No	0	8	6
106	R:R:N135	R:R:V136	5.91	No	No	0	5	7
107	R:R:M138	R:R:S141	3.07	No	No	0	6	2
108	R:R:I142	R:R:M138	5.83	No	No	0	5	6
109	R:R:M153	R:R:V343	7.61	No	Yes	2	8	4
110	R:R:I155	R:R:P156	6.77	No	No	0	5	9
111	R:R:V159	R:R:Y160	15.14	No	No	0	4	8
112	R:R:P332	R:R:T331	3.5	No	No	0	4	4
113	R:R:T331	R:R:V334	4.76	No	No	0	4	4
114	R:R:L333	R:R:T337	2.95	No	No	0	3	7
115	R:R:I338	R:R:L401	2.85	No	No	0	6	7
116	R:R:R340	R:R:Y393	8.23	No	No	0	9	9
117	R:R:F345	R:R:L341	3.65	Yes	Yes	7	9	6
118	R:R:L341	R:R:L346	2.77	Yes	No	0	6	8
119	R:R:H394	R:R:L341	3.86	No	Yes	7	9	6
120	R:R:F345	R:R:T391	2.59	Yes	No	0	9	6
121	R:R:F345	R:R:H394	14.71	Yes	No	7	9	9
122	R:R:L347	R:R:P348	3.28	No	No	0	7	9
123	R:R:L387	R:R:S349	6.01	No	No	0	6	4
124	R:R:M352	R:R:Y356	3.59	Yes	Yes	3	8	9
125	R:R:M352	R:R:V383	4.56	Yes	No	0	8	8
126	R:R:F376	R:R:Y356	7.22	Yes	Yes	3	4	9
127	R:R:A379	R:R:Y356	2.67	No	Yes	0	7	9
128	R:R:V380	R:R:Y356	7.57	No	Yes	3	3	9
129	R:R:F358	R:R:R362	7.48	Yes	No	0	6	7
130	R:R:F376	R:R:I359	6.28	Yes	No	0	4	9
131	R:R:F361	R:R:R365	16.03	No	No	0	4	4
132	R:R:R362	R:R:R365	8.53	No	No	0	7	4
133	R:R:M363	R:R:Q372	2.72	No	No	0	7	5
134	R:R:F376	R:R:V380	9.18	Yes	No	3	4	3
135	R:R:L438	R:R:V381	4.47	No	No	0	7	7
136	R:R:L434	R:R:V385	4.47	No	No	0	9	7
137	R:R:F386	R:R:W390	13.03	Yes	Yes	6	9	9
138	R:R:F386	R:R:N427	4.83	Yes	Yes	6	9	9
139	R:R:C389	R:R:N427	7.87	No	Yes	0	9	9
140	R:R:W390	R:R:Y393	6.75	Yes	No	0	9	9
141	R:R:A424	R:R:W390	6.48	No	Yes	0	9	9
142	R:R:N427	R:R:W390	6.78	Yes	Yes	6	9	9
143	R:R:P392	R:R:T391	6.99	No	No	0	9	6
144	R:R:I395	R:R:T391	3.04	No	No	0	5	6
145	R:R:C420	R:R:F396	9.78	No	No	0	6	4
146	R:R:L413	R:R:S400	6.01	Yes	No	0	7	2
147	R:R:L409	R:R:T403	2.95	No	No	0	3	2
148	R:R:D404	R:R:T407	4.34	No	No	0	4	7
149	R:R:P408	R:R:T407	5.25	No	No	0	4	7
150	R:R:L409	R:R:T412	4.42	No	No	0	3	6
151	R:R:G410	R:R:L413	5.13	No	Yes	0	3	7
152	R:R:K411	R:R:M414	2.88	No	No	4	2	2
153	R:R:D417	R:R:I421	8.4	No	No	0	8	4
154	R:R:N427	R:R:N431	5.45	Yes	No	0	9	9
155	R:R:F458	R:R:Y435	4.13	Yes	No	1	8	9
156	R:R:Q451	R:R:S449	5.78	No	No	0	6	9
157	R:R:I450	R:R:L454	2.85	No	Yes	1	4	8
158	R:R:G452	R:R:Q451	8.22	No	No	0	6	6
159	R:R:E455	R:R:Q451	6.37	Yes	No	0	9	6
160	R:R:F458	R:R:L454	3.65	Yes	Yes	1	8	8
161	R:R:V378	R:R:Y435	2.52	No	No	0	8	9
162	R:R:F93	R:R:K96	2.48	No	No	0	4	8
163	R:R:F433	R:R:L36	2.44	No	Yes	0	6	8
164	R:R:F345	R:R:L387	2.44	Yes	No	0	9	6
165	R:R:F386	R:R:L387	2.44	Yes	No	0	9	6
166	R:R:F396	R:R:L413	2.44	No	Yes	0	4	7
167	R:R:L122	R:R:W129	2.28	No	No	0	7	6
168	R:R:G37	R:R:P39	2.03	No	No	0	9	7
169	R:R:G40	R:R:P39	2.03	No	No	0	9	7
170	R:R:F396	R:R:W416	2	No	No	0	4	7
171	R:R:C72	R:R:G37	1.96	No	No	0	8	9
172	R:R:C140	R:R:G137	1.96	No	No	0	4	5
173	R:R:C143	R:R:G144	1.96	No	No	0	8	5
174	R:R:A457	R:R:G439	1.95	No	No	0	9	9
175	R:R:A456	R:R:G452	1.95	No	No	0	6	6
176	R:R:G137	R:R:V136	1.84	No	No	0	5	7
177	R:R:A108	R:R:A150	1.79	No	No	0	9	9
178	R:R:P22	R:R:V419	1.77	No	No	0	4	5
179	R:R:C72	R:R:S428	1.72	No	No	0	8	9
180	R:R:A422	R:R:S26	1.71	No	Yes	0	8	8
181	R:R:C389	R:R:V385	1.71	No	No	0	9	7
182	R:R:G42	R:R:N41	1.7	No	Yes	0	6	9
183	R:R:I336	R:R:P332	1.69	No	No	0	7	4
184	R:R:K126	R:R:P127	1.67	No	No	0	6	9
185	R:R:L38	R:R:P39	1.64	No	No	0	7	7
186	R:R:C140	R:R:I59	1.64	No	No	0	4	6
187	R:R:L423	R:R:P392	1.64	No	No	0	8	9
188	R:R:S31	R:R:V28	1.62	No	No	0	7	6
189	R:R:A422	R:R:I29	1.62	No	No	0	8	7
190	R:R:A436	R:R:I453	1.62	No	No	0	8	7
191	R:R:A83	R:R:M27	1.61	No	No	0	5	6
192	R:R:D404	R:R:P405	1.61	No	No	0	4	4
193	R:R:S371	R:R:T375	1.6	No	No	0	7	7
194	R:R:V378	R:R:V382	1.6	No	No	0	8	8
195	R:R:V381	R:R:V385	1.6	No	No	0	7	7
196	R:R:C429	R:R:L36	1.59	No	Yes	0	9	8
197	R:R:T339	R:R:V343	1.59	No	Yes	0	8	4
198	R:R:A422	R:R:L30	1.58	No	Yes	0	8	6
199	R:R:A48	R:R:L454	1.58	No	Yes	0	7	8
200	R:R:A83	R:R:L84	1.58	No	No	0	5	8
201	R:R:I155	R:R:V159	1.54	No	No	0	5	4
202	R:R:I338	R:R:V342	1.54	No	No	0	6	6
203	R:R:C130	R:R:Q131	1.53	No	No	0	7	9
204	R:R:K411	R:R:S415	1.53	No	No	4	2	5
205	R:R:M414	R:R:S415	1.53	No	No	4	2	5
206	R:R:I336	R:R:T337	1.52	No	No	0	7	7
207	R:R:L30	R:R:S78	1.5	Yes	No	0	6	8
208	R:R:L43	R:R:V44	1.49	No	No	0	8	9
209	R:R:L341	R:R:V398	1.49	Yes	No	0	6	7
210	R:R:I102	R:R:I421	1.47	No	No	0	8	4
211	R:R:I142	R:R:I146	1.47	No	No	0	5	8
212	R:R:L409	R:R:T407	1.47	No	No	0	3	7
213	R:R:L413	R:R:T412	1.47	Yes	No	0	7	6
214	R:R:I359	R:R:M363	1.46	No	No	0	9	7
215	R:R:I101	R:R:L70	1.43	Yes	No	0	5	6
216	R:R:I395	R:R:L399	1.43	No	No	0	5	9
217	R:R:I101	R:R:N105	1.42	Yes	No	0	5	9
218	R:R:C389	R:R:F430	1.4	No	No	0	9	7
219	R:R:P89	R:R:Y90	1.39	No	No	0	8	7
220	R:R:C95	R:R:R92	1.39	No	No	0	9	1
221	R:R:A457	R:R:F458	1.39	No	Yes	0	9	8
222	R:R:L32	R:R:L36	1.38	No	Yes	0	6	8
223	R:R:L35	R:R:L36	1.38	No	Yes	0	6	8
224	R:R:L45	R:R:L62	1.38	No	No	0	8	8
225	R:R:L45	R:R:L69	1.38	No	No	0	8	7
226	R:R:L333	R:R:L401	1.38	No	No	0	3	7
227	R:R:L437	R:R:L438	1.38	No	No	0	7	7
228	R:R:F77	R:R:S74	1.32	No	No	0	8	9
229	R:R:R377	R:R:S373	1.32	No	No	0	5	4
230	R:R:R134	R:R:V123	1.31	No	No	0	9	5
231	R:R:F158	R:R:V159	1.31	No	No	0	8	4
232	R:R:F376	R:R:V360	1.31	Yes	No	0	4	6
233	R:R:R377	R:R:V381	1.31	No	No	0	5	7
234	R:R:L66	R:R:W147	1.14	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S26	2.6825	4	5	8
2	R:R:L30	2.9325	4	0	6
3	R:R:L36	1.6975	4	0	8
4	R:R:N41	3.53	4	0	9
5	R:R:V47	6.5325	4	1	8
6	R:R:F61	7.65	4	1	8
7	R:R:H63	7.875	4	0	8
8	R:R:I101	3.36	4	0	5
9	R:R:F107	3.75	5	2	8
10	R:R:W147	3.7575	4	0	9
11	R:R:L341	2.9425	4	7	6
12	R:R:V343	3.61	4	2	4
13	R:R:F345	5.8475	4	7	9
14	R:R:M352	4.7075	4	3	8
15	R:R:Y356	6.5	5	3	9
16	R:R:F358	4.295	4	0	6
17	R:R:F376	5.9975	4	3	4
18	R:R:F386	5.07167	6	6	9
19	R:R:W390	8.702	5	6	9
20	R:R:L413	3.7625	4	0	7
21	R:R:N427	6.2325	4	6	9
22	R:R:L454	4.596	5	1	8
23	R:R:E455	4.67	4	0	9
24	R:R:F458	6.176	5	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A422	R:R:L30	14.824	1.58	No	Yes	0	8	6
2	R:R:A422	R:R:S26	11.5757	1.71	No	Yes	0	8	8
3	R:R:L30	R:R:S425	19.3689	4.5	Yes	No	0	6	8
4	R:R:C429	R:R:G37	11.7609	3.92	No	No	0	9	9
5	R:R:G37	R:R:P39	31.2224	2.03	No	No	0	9	7
6	R:R:L38	R:R:P39	28.2875	1.64	No	No	0	7	7
7	R:R:F34	R:R:L38	25.2956	3.65	No	No	0	7	7
8	R:R:F34	R:R:L75	22.489	9.74	No	No	0	7	9
9	R:R:L75	R:R:S425	20.9432	3	No	No	0	9	8
10	R:R:C72	R:R:N41	13.1856	3.15	No	Yes	0	8	9
11	R:R:C72	R:R:G37	42.385	1.96	No	No	0	8	9
12	R:R:C72	R:R:S428	53.6615	1.72	No	No	0	8	9
13	R:R:D68	R:R:S428	71.6626	10.31	No	No	0	9	9
14	R:R:D68	R:R:N431	72.6243	4.04	No	No	0	9	9
15	R:R:N427	R:R:N431	73.5717	5.45	Yes	No	0	9	9
16	R:R:F386	R:R:N427	74.0633	4.83	Yes	Yes	6	9	9
17	R:R:F386	R:R:S109	51.2537	2.64	Yes	No	0	9	9
18	R:R:L64	R:R:S109	50.7337	3	No	No	0	9	9
19	R:R:L112	R:R:L64	100	2.77	No	No	0	9	9
20	R:R:H63	R:R:L112	91.1383	2.57	Yes	No	0	8	9
21	R:R:C143	R:R:H63	73.1942	16.22	No	Yes	0	8	8
22	R:R:C143	R:R:W60	69.9886	3.92	No	No	0	8	8
23	R:R:I116	R:R:W60	57.1948	4.7	No	No	0	9	8
24	R:R:F61	R:R:I116	50.1923	3.77	Yes	No	0	8	9
25	R:R:F458	R:R:F61	40.8391	13.93	Yes	Yes	1	8	8
26	R:R:F458	R:R:L454	34.1573	3.65	Yes	Yes	1	8	8
27	R:R:F386	R:R:L113	51.2537	4.87	Yes	No	0	9	8
28	R:R:L113	R:R:L64	50.7337	2.77	No	No	0	8	9
29	R:R:L454	R:R:V47	21.7196	11.92	Yes	Yes	1	8	8
30	R:R:E455	R:R:V47	15.3441	2.85	Yes	Yes	0	9	8
31	R:R:D119	R:R:W60	11.59	8.93	No	No	0	9	8
32	R:R:H63	R:R:I59	11.07	5.3	Yes	No	0	8	6
33	R:R:H63	R:R:W147	11.07	7.41	Yes	Yes	0	8	9
34	R:R:C71	R:R:S428	25.2671	3.44	No	No	0	8	9
35	R:R:C71	R:R:N105	23.7498	11.02	No	No	0	8	9
36	R:R:I101	R:R:N105	17.994	1.42	Yes	No	0	5	9
37	R:R:I101	R:R:S74	13.4421	7.74	Yes	No	0	5	9
38	R:R:F77	R:R:S74	11.8108	1.32	No	No	0	8	9
39	R:R:F77	R:R:I98	10.1653	5.02	No	No	0	8	8
40	R:R:R340	R:R:Y393	12.1314	8.23	No	No	0	9	9
41	R:R:W390	R:R:Y393	13.7199	6.75	Yes	No	0	9	9
42	R:R:F111	R:R:V110	11.5187	2.62	No	No	0	8	9
43	R:R:F386	R:R:V110	50.2849	2.62	Yes	No	0	9	9
44	R:R:P348	R:R:V110	43.0118	3.53	No	No	0	9	9
45	R:R:I146	R:R:L112	10.785	2.85	No	No	0	8	9
46	R:R:P348	R:R:T114	40.3619	3.5	No	No	0	9	8
47	R:R:M352	R:R:T114	36.3869	3.01	Yes	No	0	8	8
48	R:R:M352	R:R:Y356	31.9989	3.59	Yes	Yes	3	8	9
49	R:R:C121	R:R:I359	20.9859	3.27	No	No	0	9	9
50	R:R:F376	R:R:I359	25.5165	6.28	Yes	No	0	4	9
51	R:R:F376	R:R:Y356	28.1308	7.22	Yes	Yes	3	4	9
52	R:R:C121	R:R:F358	17.88	2.79	No	Yes	0	9	6
53	R:R:F345	R:R:L387	15.1945	2.44	Yes	No	0	9	6
54	R:R:F386	R:R:L387	18.3146	2.44	Yes	No	0	9	6
55	R:R:C389	R:R:V385	11.3406	1.71	No	No	0	9	7
56	R:R:C389	R:R:N427	14.589	7.87	No	Yes	0	9	9
57	R:R:F386	R:R:W390	12.516	13.03	Yes	Yes	6	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9ISI

PDB Summary
PDB	9ISI
Class	A
SubFamily	Peptide
Type	Complement Peptide
SubType	C3A
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.56
Date	2025-04-23
D.O.I.	doi.org/10.1038/s44318-025-00429-w

Net Summary
I_min	2.57
Number of Linked Nodes	226
Number of Links	234
Number of Hubs	24
Number of Links mediated by Hubs	91
Number of Communities	7
Number of Nodes involved in Communities	28
Number of Links involved in Communities	31

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	24149
Length Of Smallest Path	3
Average Path Length	14.6626
Length of Longest Path	34
Minimum Path Strength	1.315
Average Path Strength	4.70738
Maximum Path Strength	12.28
Minimum Path Correlation	0.7
Average Path Correlation	0.914999
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	48.9644
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	28.7849
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • complement component C3a receptor activity • molecular transducer activity • complement receptor activity • transmembrane signaling receptor activity • signaling receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • G protein-coupled receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • response to stimulus • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • response to stimulus • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of biological process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • response to chemical • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • biological regulation • positive regulation of leukocyte migration • regulation of chemotaxis • cellular response to chemical stimulus • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • system process • circulatory system process • blood circulation • cellular anatomical structure • periplasmic space • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • specific granule membrane • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • specific granule membrane • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • cell periphery • plasma membrane
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>9ISI_Chain_R P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G S I Q G I L E A A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a anaphylatoxin	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9ISI.zip

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