Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P22 6.48754144
2R:R:L30 5.4765156
3R:R:T33 4.5225158
4R:R:L38 3.64254187
5R:R:N41 4.074509
6R:R:W46 4.715456
7R:R:V47 3.685658
8R:R:K51 5.785459
9R:R:T58 3.98754198
10R:R:W60 4.55508
11R:R:L64 4.864599
12R:R:D68 6.702599
13R:R:L75 4.078336159
14R:R:Q87 8.7525406
15R:R:W88 9.056569
16R:R:C95 6.44469
17R:R:K96 8.05468
18R:R:I98 9.024218
19R:R:T114 3.55254228
20R:R:V123 4.6354205
21R:R:R134 6.354209
22R:R:R161 8.25333668
23R:R:I163 6.65466
24R:R:C172 5.9675468
25R:R:I336 2.615407
26R:R:R367 5.1165246
27R:R:T375 4.8725407
28R:R:L387 2.3975406
29R:R:W390 5.26709
30R:R:T391 5.3475406
31R:R:Y393 5.1075409
32R:R:F396 3.7025404
33R:R:L413 7.114257
34R:R:W416 5.1985147
35R:R:N431 7.1525499
36R:R:Y435 5.416599
37R:R:F442 4.92559
38R:R:K445 4.675457
39A:A:K46 2.95409
40A:A:T48 2.48409
41A:A:M53 3.592508
42A:A:F197 5.938507
43A:A:R198 9.365416
44A:A:F200 7.146516
45A:A:Q205 4.44419
46A:A:S207 3.965418
47A:A:W212 4.378519
48A:A:F216 4.202519
49A:A:I222 3.7775417
50A:A:L228 5.8075487
51A:A:F251 5.43333689
52A:A:N257 3.775418
53A:A:F260 5.26519
54A:A:L267 3.575489
55A:A:F268 5.18754109
56A:A:L269 3.5275488
57A:A:F275 8.1175408
58A:A:P283 3.04405
59A:A:F288 6.7654298
60A:A:F308 5.79488
61A:A:I319 4.815485
62A:A:Y320 4.5185248
63A:A:H322 6.5354108
64A:A:T324 6.47754109
65A:A:N331 7.354108
66A:A:F336 5.875408
67A:A:Y354 6.194505
68B:B:L4 2.95404
69B:B:I18 3.135407
70B:B:I37 3.636542
71B:B:L51 6.895409
72B:B:H54 6.83143779
73B:B:W63 6.0625407
74B:B:D76 5.96579
75B:B:I80 4.466578
76B:B:W82 7.34143779
77B:B:K89 7.25579
78B:B:L95 5.164118
79B:B:W99 5.46429719
80B:B:Y105 3.9375406
81B:B:N110 5.73754334
82B:B:Y111 5.46404
83B:B:Y124 4.1865116
84B:B:E138 5.955406
85B:B:L139 6.0325409
86B:B:H142 7.7665169
87B:B:Y145 7.25333618
88B:B:F151 4.2925329
89B:B:L152 5.95254343
90B:B:S160 4.04426
91B:B:S161 6.4725169
92B:B:D163 8.42754169
93B:B:W169 9.652508
94B:B:F180 5.9475427
95B:B:H183 8.36529
96B:B:V187 6.1825429
97B:B:L190 3.505425
98B:B:F199 7.6429
99B:B:K209 6.662526
100B:B:L210 4.355405
101B:B:W211 7.315628
102B:B:Q220 7.845437
103B:B:F222 6.145438
104B:B:H225 7.67639
105B:B:D228 7.87754269
106B:B:I232 5.61538
107B:B:F234 6.31405
108B:B:F235 7.874297126
109B:B:P236 5.6554127
110B:B:N237 7.34125
111B:B:F241 6.055636
112B:B:T243 6.396538
113B:B:R251 8.025408
114B:B:F253 7.338536
115B:B:D254 4.225409
116B:B:R256 5.83254359
117B:B:D258 8.5675437
118B:B:Q259 4.674506
119B:B:F278 5.45754127
120B:B:R283 7.6875449
121B:B:L285 4.7475406
122B:B:Y289 9.0365137
123B:B:N295 7.1085136
124B:B:W297 6.44754138
125B:B:D298 8.2449
126B:B:L300 5.2446
127B:B:K301 5.9525445
128B:B:R304 7.94254135
129B:B:H311 7.0285179
130B:B:L318 3.83406
131B:B:W332 8.0125409
132B:B:D333 5.4925179
133B:B:W339 7.082509
134G:G:L19 3.1045309
135G:G:Y40 5.9754126
136G:G:D48 7.8775409
137G:G:F61 4.4545318
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F396 R:R:W416 11.09433.01YesYes047
2R:R:F396 R:R:I395 22.16613.77YesNo045
3R:R:I395 R:R:T391 23.2724.56NoYes056
4R:R:F345 R:R:T391 12.741310.38NoYes096
5R:R:F345 R:R:H394 13.29197.92NoNo099
6R:R:H394 R:R:W390 14.94436.35NoYes099
7R:R:N427 R:R:W390 60.14817.91NoYes099
8R:R:N427 R:R:N431 62.81148.17NoYes099
9R:R:D68 R:R:N41 21.52534.04YesYes099
10R:R:G37 R:R:N41 20.4253.39NoYes099
11R:R:G37 R:R:P39 20.14942.03NoNo097
12R:R:L38 R:R:P39 19.59743.28YesNo077
13R:R:L387 R:R:T391 12.74652.95YesYes066
14R:R:F386 R:R:L387 15.50063.65NoYes096
15R:R:F386 R:R:W390 16.05124.01NoYes099
16R:R:L38 R:R:L69 10.07161.38YesNo1877
17R:R:L64 R:R:N431 31.12194.12YesYes999
18R:R:L64 R:R:Y435 52.84193.52YesYes999
19R:R:I116 R:R:Y435 85.13256.04NoYes099
20R:R:I116 R:R:W60 88.22523.52NoYes098
21R:R:D119 R:R:W60 93.00395.58NoYes098
22R:R:L113 R:R:N431 31.11518.24NoYes989
23R:R:L113 R:R:Y435 31.36089.38NoYes989
24R:R:M106 R:R:W390 17.79435.82NoYes099
25R:R:I102 R:R:M106 17.24374.37NoNo089
26R:R:I102 R:R:I98 16.13782.94NoYes088
27R:R:I98 R:R:P99 12.25993.39YesNo088
28R:R:C95 R:R:P99 11.7053.77YesNo098
29R:R:W390 R:R:Y393 10.59453.86YesYes099
30R:R:D119 R:R:V123 92.63044.38NoYes2095
31A:A:F197 A:A:V339 97.55643.93YesNo078
32A:A:I343 A:A:V339 97.33613.07NoNo088
33A:A:I343 A:A:N347 97.24142.83NoNo088
34A:A:N347 R:R:V123 97.02045.91NoYes085
35A:A:H214 B:B:W332 31.15045.29NoYes089
36A:A:F259 A:A:H214 28.81116.79NoNo048
37A:A:F259 A:A:N257 29.27314.83NoYes048
38A:A:F260 A:A:N257 27.40396.04YesYes198
39A:A:F260 A:A:I222 50.29366.28YesYes197
40A:A:I222 A:A:I265 82.95892.94YesNo076
41A:A:F251 A:A:I265 82.97376.28YesNo096
42A:A:F251 A:A:F308 94.00573.22YesYes898
43A:A:F308 A:A:V226 94.51056.55YesNo087
44A:A:S247 A:A:V226 1008.08NoNo097
45A:A:A41 A:A:S247 99.97011.71NoNo079
46A:A:A41 A:A:S44 99.94051.71NoNo079
47A:A:K46 A:A:S44 49.65673.06YesNo099
48A:A:K46 A:A:L38 49.30634.23YesNo098
49A:A:I49 A:A:L38 49.16674.28NoNo078
50A:A:I49 A:A:M53 97.90874.37NoYes078
51A:A:F190 A:A:M53 97.1094.98NoYes088
52A:A:F190 A:A:F197 96.91259.65NoYes087
53A:A:C225 A:A:S44 50.27753.44NoNo079
54A:A:C225 A:A:N270 50.20753.15NoNo079
55A:A:I49 A:A:N270 48.94914.25NoNo079
56A:A:F216 A:A:L37 32.47854.87YesNo099
57A:A:I222 A:A:L37 32.52752.85YesNo079
58A:A:F224 A:A:F251 23.033610.72NoYes099
59A:A:F275 A:A:L228 10.247513.4YesYes087
60A:A:L228 A:A:L269 10.66134.15YesYes878
61A:A:I213 A:A:W212 24.91613.52NoYes189
62A:A:F260 A:A:I213 22.9295.02YesNo198
63A:A:F216 A:A:W212 22.89654.01YesYes199
64A:A:S207 A:A:W212 46.36714.94YesYes189
65A:A:S207 B:B:Y145 45.5595.09YesYes188
66A:A:K211 B:B:Y145 22.51063.58NoYes098
67A:A:E208 A:A:K211 22.50722.7NoNo099
68A:A:E208 A:A:K210 22.50612.7NoNo097
69A:A:K210 A:A:R209 22.5064.95NoNo079
70A:A:L250 A:A:R209 22.68534.86NoNo099
71A:A:F224 A:A:L250 22.79626.09NoNo099
72B:B:I18 G:G:E22 39.68414.1YesNo079
73B:B:T221 G:G:E22 38.740112.7NoNo079
74B:B:K209 B:B:T221 39.08167.51YesNo067
75B:B:H183 B:B:K209 40.577511.79YesYes296
76B:B:H183 B:B:V187 44.3078.3YesYes299
77B:B:S160 B:B:V187 46.72486.46YesYes269
78B:B:S147 B:B:S160 55.04853.26NoYes096
79B:B:M188 B:B:S147 55.40024.6NoNo089
80B:B:M188 B:B:Y145 55.76179.58NoYes088
81B:B:I18 B:B:R22 30.7453.76YesNo076
82B:B:D258 B:B:R22 25.69734.76YesNo076
83B:B:R283 B:B:V40 12.52586.54YesNo493
84B:B:A305 B:B:V40 13.95121.7NoNo043
85B:B:A305 B:B:V296 14.21971.7NoNo045
86B:B:L286 B:B:V296 13.777310.43NoNo075
87B:B:L286 B:B:V327 14.03712.98NoNo076
88B:B:V327 B:B:W339 13.99753.68NoYes069
89B:B:H311 B:B:T329 14.20886.85YesNo098
90B:B:D333 B:B:H311 23.46295.04YesYes1799
91B:B:D333 B:B:N313 24.75874.04YesNo097
92B:B:N313 B:B:W332 25.10475.65NoYes079
93B:B:F222 B:B:F253 10.61445.36YesYes386
94B:B:D258 B:B:F222 21.55975.97YesYes378
95B:B:H142 B:B:W169 12.93085.29YesYes098
96B:B:H142 B:B:S161 14.571815.34YesYes1699
97B:B:G162 B:B:S161 16.64441.86NoYes099
98B:B:G162 B:B:Y145 17.055910.14NoYes098
99B:B:F222 B:B:F241 10.60168.57YesYes386
100R:R:D68 R:R:L64 21.22848.14YesYes999
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8I9S
Class A
SubFamily Peptide
Type Complement peptide
SubType C3A
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.26
Date 2023-10-18
D.O.I. 10.1016/j.cell.2023.09.020
Net Summary
Imin 2.83
Number of Linked Nodes 821
Number of Links 948
Number of Hubs 137
Number of Links mediated by Hubs 508
Number of Communities 36
Number of Nodes involved in Communities 180
Number of Links involved in Communities 236
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 1274974
Length Of Smallest Path 3
Average Path Length 36.8744
Length of Longest Path 71
Minimum Path Strength 1.285
Average Path Strength 5.29415
Maximum Path Strength 24.245
Minimum Path Correlation 0.7
Average Path Correlation 0.981197
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 37.0518
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.2384
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8I9S_Chain_R
NEPPVILSM VILSLTFLL GLPGNGLVL WVAGLKMQR TVNTIWFLH 
LTLADLLCC LSLPFSLAH LALQGQWPY GRFLCKLIP SIIVLNMFA 
SVFLLTAIS LDRCLVVFK PIWCQNHRN VGMACSICG CIWVVAFVM 
CIPVFVYRE IFTTDNHNR CGYTPLVAI TITRLVVGF LLPSVIMIA 
CYSFIVFRM QRGRFAKSQ SKTFRVAVV VVAVFLVCW TPYHIFGVL 
SLLTDPETP LGKTLMSWD HVCIALASA NSCFNPFLY ALLGKDFRK 
KARQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>8I9S_Chain_A
SAEERAALE RSKAIEKNL KEDGISAAK DVKLLLLGA DNSGKSTIV 
KQMKITGIV ETHFTFKNL HFRLFDVGG QRSERKKWI HCFEDVTAI 
IFCVDLSDR MHESLMLFD SICNNKFFI DTSIILFLN KKDLFGEKI 
KKSPLTICF PEYTGPNTY EDAAAYIQA QFESKNRSP NKEIYCHMT 
CATDTNNAQ VIFDAVTDI IIANNLRGC GLY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8I9S_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8I9S_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement peptideC3aBHomo sapiensC3a anaphylatoxin-Gi1/&β;1/&γ;22.92023-05-1010.1038/s41589-023-01339-w
8HK3APeptideComplement peptideC3aBHomo sapiens--Gi1/&β;1/&γ;23.22023-05-1010.1038/s41589-023-01339-w
8I95APeptideComplement peptideC3aBHomo sapiensEP54-Go/&β;1/&γ;22.882023-10-1810.1016/j.cell.2023.09.020
8I97APeptideComplement peptideC3aBHomo sapiens--Go/&β;1/&γ;23.12023-10-1810.1016/j.cell.2023.09.020
8I9AAPeptideComplement peptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.572023-10-1810.1016/j.cell.2023.09.020
8I9LAPeptideComplement peptideC3aBHomo sapiensC3a anaphylatoxin-Go/&β;1/&γ;23.182023-10-1810.1016/j.cell.2023.09.020
8IA8APeptideComplement peptideC3aBHomo sapiensE7 peptide-Gi1/&β;1/&γ;22.862023-05-24To be published
8J6DAPeptideComplement peptideC3aBHomo sapiensEP141-Go/&β;1/&γ;23.12023-10-1810.1016/j.cell.2023.09.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I9S.zip



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