Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K46 2.708509
2A:A:T48 2.48409
3A:A:H196 7.135413
4A:A:F197 5.305607
5A:A:R198 8.942516
6A:A:F200 7.146516
7A:A:Q205 3.775619
8A:A:S207 3.965418
9A:A:K211 4.046519
10A:A:W212 4.02833619
11A:A:C215 3.135416
12A:A:F216 3.70857719
13A:A:E217 5.6075417
14A:A:I222 4.1475417
15A:A:F224 4.63719
16A:A:V226 5.0575417
17A:A:L228 5.8075417
18A:A:F251 5.85167619
19A:A:N257 3.775418
20A:A:F260 5.26519
21A:A:I265 6.03416
22A:A:I266 4.0925408
23A:A:L267 3.575419
24A:A:F268 3.687129
25A:A:L269 3.5275418
26A:A:N270 5.0154129
27A:A:F275 5.98714718
28A:A:P283 3.04405
29A:A:L284 4.08417
30A:A:F288 4.92143718
31A:A:I304 2.595418
32A:A:F308 4.71833618
33A:A:I319 5.03515
34A:A:Y320 4.518588
35A:A:H322 5.195128
36A:A:T324 5.724129
37A:A:I335 4.7825408
38A:A:F336 5.2025108
39A:A:L348 3.67488
40A:A:R349 5.835404
41A:A:L353 3.9925406
42A:A:Y354 5.716585
43B:B:I18 2.8225407
44B:B:I37 3.636532
45B:B:M45 4.89434
46B:B:R48 4.7775447
47B:B:R49 4.1447
48B:B:L51 6.895449
49B:B:H54 6.235649
50B:B:I58 5.4725449
51B:B:Y59 6.0425418
52B:B:M61 4.1925446
53B:B:W63 6.096507
54B:B:R68 9.405475
55B:B:L69 4.69475
56B:B:L70 4.6445
57B:B:W82 8.0225849
58B:B:K89 6.792549
59B:B:H91 4.595475
60B:B:L95 6.342578
61B:B:W99 5.1075819
62B:B:Y105 3.435606
63B:B:N110 5.73754174
64B:B:Y111 4.8285174
65B:B:C114 3.725478
66B:B:L117 3.895619
67B:B:Y124 4.186576
68B:B:V133 4.305474
69B:B:L139 6.0325409
70B:B:H142 5.6875899
71B:B:Y145 5.415818
72B:B:R150 4.2125456
73B:B:F151 4.4225409
74B:B:L152 5.95254133
75B:B:N155 5.6954133
76B:B:T159 4.715499
77B:B:S160 4.04456
78B:B:D163 8.4275499
79B:B:A167 3.735494
80B:B:W169 8.475698
81B:B:D170 4.134139
82B:B:I171 5.035406
83B:B:F180 5.246557
84B:B:H183 7.66333659
85B:B:D186 4.066519
86B:B:V187 6.125459
87B:B:L190 3.20333655
88B:B:A193 2.72464
89B:B:F199 6.604559
90B:B:K209 6.662556
91B:B:L210 4.355405
92B:B:W211 7.315658
93B:B:Q220 8.1875467
94B:B:F222 5.03833668
95B:B:H225 8.59669
96B:B:D228 8.1425419
97B:B:I232 5.61508
98B:B:F234 5.536565
99B:B:F235 5.97571736
100B:B:P236 5.655437
101B:B:F241 5.81333666
102B:B:T243 8.2525468
103B:B:R251 6.848568
104B:B:F253 5.82333666
105B:B:D254 3.5425409
106B:B:R256 4.9045189
107B:B:D258 8.5675467
108B:B:Q259 4.4725406
109B:B:Y264 3.224505
110B:B:I269 3.58754144
111B:B:F278 5.4575437
112B:B:R283 5.44143739
113B:B:L284 3.1675435
114B:B:L285 4.7475406
115B:B:Y289 8.42254147
116B:B:N295 7.1085146
117B:B:V296 3.8405
118B:B:W297 6.44754148
119B:B:D298 8.2439
120B:B:L300 5.2436
121B:B:K301 5.258535
122B:B:R304 7.94254145
123B:B:H311 7.028519
124B:B:N313 4.835417
125B:B:R314 9.2125418
126B:B:L318 4.26506
127B:B:M325 3.902545
128B:B:W332 7.57667619
129B:B:D333 4.96519
130B:B:L336 3.355447
131B:B:W339 6.29639
132B:B:N340 4.7375449
133G:G:L19 3.83409
134G:G:Y40 6.5575436
135G:G:H44 4.6175406
136G:G:D48 6.256539
137G:G:L51 5.7975436
138G:G:F61 3.6925848
139R:R:P22 7.2754164
140R:R:L30 5.025626
141R:R:T33 4.522528
142R:R:G37 2.335429
143R:R:L38 3.64254237
144R:R:N41 4.074529
145R:R:V47 3.5125198
146R:R:T58 4.5854248
147R:R:W60 4.22667608
148R:R:H63 7.2125408
149R:R:L64 4.864529
150R:R:D68 6.702529
151R:R:L75 3.89143729
152R:R:Q87 9.51754256
153R:R:W88 6.6445119
154R:R:C95 5.464119
155R:R:I102 4.5408
156R:R:L113 6.4428
157R:R:T114 3.55254268
158R:R:I116 4.27429
159R:R:V123 4.6354155
160R:R:W129 6.37254156
161R:R:R134 6.354159
162R:R:W147 4.25409
163R:R:R161 8.5625118
164R:R:I163 6.30254116
165R:R:C172 4.3354118
166R:R:Y356 4.926509
167R:R:I359 3.36254219
168R:R:R362 4.0975407
169R:R:M363 5.22587
170R:R:R367 5.116586
171R:R:F368 6.0475485
172R:R:F386 3.18429
173R:R:L387 2.406526
174R:R:W390 5.26729
175R:R:T391 5.3475426
176R:R:Y393 5.1075409
177R:R:F396 3.7025404
178R:R:L413 7.11407
179R:R:W416 5.1985167
180R:R:C429 4.02429
181R:R:N431 7.1525429
182R:R:Y435 4.91167629
183R:R:F442 5.1925409
184R:R:K445 3.91254197
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L51 B:B:W82 39.037314.81YesYes499
2B:B:I338 B:B:L51 57.41974.28NoYes459
3B:B:I338 G:G:F61 56.65785.02NoYes458
4B:B:Y85 G:G:F61 97.07334.13NoYes048
5B:B:R68 B:B:Y85 98.868918.52YesNo054
6B:B:L69 B:B:R68 97.87622.43YesYes755
7B:B:I81 B:B:L69 10.62868.56NoYes775
8A:A:I49 A:A:L38 21.49034.28NoNo078
9A:A:K46 A:A:L38 21.91064.23YesNo098
10A:A:G40 A:A:K46 40.43571.74NoYes099
11A:A:F224 A:A:G40 40.63943.01YesNo099
12A:A:F224 A:A:I254 72.46272.51YesNo198
13A:A:F260 A:A:I254 72.86113.77YesNo198
14A:A:F260 A:A:N257 89.75036.04YesYes198
15A:A:F259 A:A:N257 92.91334.83NoYes048
16A:A:F259 A:A:H214 46.53116.79NoNo048
17A:A:H214 B:B:W332 60.51795.29NoYes089
18B:B:S316 B:B:W332 1004.94NoYes099
19B:B:I58 B:B:S316 41.36043.1YesNo099
20B:B:H54 B:B:I58 21.02717.95YesYes499
21A:A:E217 A:A:F259 46.58417YesNo074
22A:A:E217 B:B:W332 46.7312.18YesYes179
23B:B:H54 B:B:W82 20.22923.17YesYes499
24B:B:I58 B:B:S72 20.22573.1YesNo499
25B:B:S72 B:B:W82 20.17323.71NoYes499
26A:A:C215 B:B:Y59 18.33832.69YesYes168
27A:A:H214 B:B:Y59 13.917.62NoYes088
28B:B:K57 B:B:Y59 13.9415.97NoYes198
29B:B:K57 B:B:W332 14.016317.4NoYes199
30A:A:F268 A:A:N270 25.20562.42YesYes1299
31A:A:I49 A:A:N270 12.69564.25NoYes079
32A:A:F268 A:A:I266 20.83022.51YesYes098
33A:A:C225 A:A:N270 15.23823.15NoYes079
34A:A:C225 A:A:S44 19.44583.44NoNo079
35A:A:K46 A:A:S44 17.64493.06YesNo099
36A:A:F260 A:A:I222 16.5916.28YesYes197
37B:B:L117 B:B:W99 10.71856.83YesYes199
38B:B:L117 B:B:Y145 11.66722.34YesYes198
39A:A:I222 A:A:I265 16.66254.42YesYes176
40A:A:F224 A:A:V226 19.18412.62YesYes197
41A:A:F224 A:A:F251 14.680510.72YesYes199
42A:A:F251 A:A:I265 14.21788.79YesYes196
43A:A:F308 A:A:V226 13.04876.55YesYes187
44A:A:F251 A:A:F308 26.09593.22YesYes198
45A:A:F275 A:A:I304 14.30582.51YesYes188
46A:A:F308 A:A:I304 27.26312.51YesYes188
47A:A:F288 A:A:L248 12.25822.44YesNo087
48A:A:F308 A:A:L248 12.93769.74YesNo087
49A:A:F288 A:A:I304 12.2642.51YesYes188
50A:A:A338 A:A:Y320 17.69592.67NoYes078
51A:A:A338 A:A:I266 18.51883.25NoYes078
52R:R:F368 R:R:R367 11.96793.21YesYes856
53A:A:Y320 R:R:R367 13.09847.2YesYes886
54A:A:L284 A:A:Y291 11.3115.86YesNo076
55A:A:D299 A:A:Y291 14.49719.2NoNo046
56A:A:D299 A:A:P294 10.8738.05NoNo041
57B:B:N313 B:B:W332 23.26745.65YesYes179
58B:B:D333 B:B:N313 23.26694.04YesYes197
59B:B:D312 B:B:D333 13.67852.66NoYes059
60B:B:D312 R:R:K445 13.6054.15NoYes057
61R:R:K445 R:R:V47 12.93593.04YesYes1978
62R:R:F442 R:R:V47 12.47436.55YesYes098
63R:R:F442 R:R:V44 11.81077.87YesNo099
64R:R:T65 R:R:V44 11.61813.17NoNo099
65R:R:L45 R:R:T65 11.55671.47NoNo089
66R:R:L45 R:R:L69 11.49611.38NoNo087
67R:R:L38 R:R:L69 11.35991.38YesNo2377
68R:R:L38 R:R:P39 10.00113.28YesNo077
69R:R:G37 R:R:N41 10.26493.39YesYes299
70R:R:D68 R:R:N41 10.22944.04YesYes299
71B:B:L69 B:B:Y105 87.0432.34YesYes056
72B:B:H62 B:B:Y105 85.42663.27NoYes066
73B:B:H62 B:B:R150 85.09656.77NoYes066
74B:B:L190 B:B:R150 83.73682.43YesYes556
75B:B:F199 B:B:L190 78.63214.87YesYes595
76B:B:F199 B:B:W211 59.162213.03YesYes598
77B:B:K209 B:B:W211 28.2495.8YesYes568
78B:B:K209 B:B:T221 27.26837.51YesNo067
79B:B:T221 G:G:E22 26.922812.7NoNo079
80B:B:I18 G:G:E22 53.09434.1YesNo079
81B:B:I18 G:G:L19 12.62971.43YesYes079
82B:B:C218 B:B:W211 27.90315.22NoYes558
83B:B:C218 G:G:Q18 27.5596.1NoNo059
84G:G:E22 G:G:Q18 26.86627.65NoNo099
85B:B:I18 B:B:R22 39.18092.51YesNo076
86B:B:F222 B:B:R22 30.08763.21YesNo686
87B:B:S281 G:G:D48 13.73555.89NoYes099
88B:B:S281 G:G:H44 13.55334.18NoYes096
89G:G:H44 G:G:Y40 12.64645.44YesYes066
90B:B:L70 B:B:W63 19.65669.11YesYes057
91B:B:F278 B:B:L285 11.13019.74YesYes076
92B:B:L318 B:B:T329 14.77595.9YesNo068
93B:B:M45 B:B:W339 13.13182.33YesYes349
94G:G:D48 G:G:L50 12.72982.71YesNo399
95B:B:H311 B:B:T329 21.65726.85YesNo098
96B:B:L70 B:B:M61 19.61674.24YesYes456
97B:B:L336 B:B:M61 19.4632.83YesYes476
98B:B:C317 B:B:M61 58.68416.48NoYes076
99B:B:A328 B:B:M61 19.61583.22NoYes056
100B:B:A328 B:B:W63 19.5823.89NoYes057
101B:B:S84 B:B:W63 42.6166.18NoYes057
102B:B:F199 B:B:V213 16.91772.62YesNo094
103B:B:L152 B:B:V213 16.21664.47YesNo034
104B:B:D153 B:B:L152 15.16236.79NoYes1353
105B:B:D153 B:B:N155 14.81424.04NoYes1353
106B:B:I171 B:B:N155 14.50452.83YesYes063
107B:B:I123 B:B:I171 13.422513.25NoYes066
108B:B:F222 B:B:F241 11.20138.57YesYes686
109B:B:C317 B:B:S316 58.67233.44NoNo079
110B:B:L336 B:B:L51 19.40635.54YesYes479
111B:B:S84 G:G:F61 42.49922.64NoYes058
112B:B:D333 B:B:H311 28.74685.04YesYes199
113B:B:M45 G:G:L50 13.01234.24YesNo349
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8I9S
Class A
SubFamily Peptide
Type Complement Peptide
SubType C3A
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.26
Date 2023-10-18
D.O.I. 10.1016/j.cell.2023.09.020
Net Summary
Imin 1.96
Number of Linked Nodes 820
Number of Links 1030
Number of Hubs 184
Number of Links mediated by Hubs 672
Number of Communities 26
Number of Nodes involved in Communities 269
Number of Links involved in Communities 403
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 2913874
Length Of Smallest Path 3
Average Path Length 30.5073
Length of Longest Path 60
Minimum Path Strength 1.285
Average Path Strength 5.17722
Maximum Path Strength 20.325
Minimum Path Correlation 0.7
Average Path Correlation 0.988621
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 42.1635
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.0453
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of locomotion   • regulation of cell motility   • regulation of cellular process   • response to stimulus   • macrophage migration   • positive regulation of chemotaxis   • positive regulation of cell migration   • taxis   • cell migration   • regulation of immune system process   • regulation of mononuclear cell migration   • positive regulation of immune system process   • chemotaxis   • regulation of biological process   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of macrophage migration   • response to external stimulus   • positive regulation of leukocyte chemotaxis   • granulocyte migration   • leukocyte migration   • regulation of response to stimulus   • response to chemical   • regulation of locomotion   • regulation of response to external stimulus   • macrophage chemotaxis   • positive regulation of biological process   • positive regulation of response to stimulus   • regulation of granulocyte chemotaxis   • regulation of macrophage migration   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • myeloid leukocyte migration   • positive regulation of mononuclear cell migration   • cell motility   • locomotion   • positive regulation of cellular process   • cell chemotaxis   • regulation of macrophage chemotaxis   • biological regulation   • positive regulation of leukocyte migration   • regulation of chemotaxis   • cellular response to chemical stimulus   • immune system process   • granulocyte chemotaxis   • mononuclear cell migration   • positive regulation of macrophage chemotaxis   • cellular process   • leukocyte chemotaxis   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • multicellular organismal process   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • regulation of vascular endothelial growth factor production   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • vascular endothelial growth factor production   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • positive regulation of vascular endothelial growth factor production   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • regulation of developmental process   • angiogenesis   • regulation of vasculature development   • positive regulation of developmental process   • multicellular organism development   • tube morphogenesis   • anatomical structure development   • regulation of anatomical structure morphogenesis   • blood vessel development   • system development   • developmental process   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • positive regulation of angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • immune response-regulating cell surface receptor signaling pathway   • complement receptor mediated signaling pathway   • immune response-activating signaling pathway   • immune response-regulating signaling pathway   • positive regulation of immune response   • cell surface receptor signaling pathway   • immune response-activating cell surface receptor signaling pathway   • immune response   • regulation of immune response   • activation of immune response   • defense response   • response to stress   • inflammatory response   • positive regulation of neutrophil chemotaxis   • neutrophil migration   • positive regulation of granulocyte chemotaxis   • regulation of neutrophil chemotaxis   • regulation of neutrophil migration   • neutrophil chemotaxis   • positive regulation of neutrophil migration   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • system process   • circulatory system process   • blood circulation   • membrane-bounded organelle   • intracellular anatomical structure   • membrane   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • specific granule membrane   • intracellular organelle   • cytoplasmic vesicle membrane   • cellular anatomical structure   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • organelle
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular anatomical structure   • membrane   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • specific granule membrane   • intracellular organelle   • cytoplasmic vesicle membrane   • cellular anatomical structure   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • organelle membrane   • secretory granule membrane   • specific granule   • lytic vacuole   • lysosome   • vacuolar membrane   • azurophil granule   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • primary lysosome   • azurophil granule membrane   • cell periphery   • plasma membrane   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • mu-type opioid receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cation binding   • metal ion binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • protein localization   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • cellular macromolecule localization   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • postsynapse   • postsynaptic membrane   • synapse   • cell junction   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-activating dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • cytosol   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>8I9S_Chain_A
SAEERAALE RSKAIEKNL KEDGISAAK DVKLLLLGA DNSGKSTIV 
KQMKITGIV ETHFTFKNL HFRLFDVGG QRSERKKWI HCFEDVTAI 
IFCVDLSDR MHESLMLFD SICNNKFFI DTSIILFLN KKDLFGEKI 
KKSPLTICF PEYTGPNTY EDAAAYIQA QFESKNRSP NKEIYCHMT 
CATDTNNAQ VIFDAVTDI IIANNLRGC GLY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8I9S_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8I9S_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ16581
Sequence
>8I9S_Chain_R
NEPPVILSM VILSLTFLL GLPGNGLVL WVAGLKMQR TVNTIWFLH 
LTLADLLCC LSLPFSLAH LALQGQWPY GRFLCKLIP SIIVLNMFA 
SVFLLTAIS LDRCLVVFK PIWCQNHRN VGMACSICG CIWVVAFVM 
CIPVFVYRE IFTTDNHNR CGYTPLVAI TITRLVVGF LLPSVIMIA 
CYSFIVFRM QRGRFAKSQ SKTFRVAVV VVAVFLVCW TPYHIFGVL 
SLLTDPETP LGKTLMSWD HVCIALASA NSCFNPFLY ALLGKDFRK 
KARQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-1810.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-1810.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-1810.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-1810.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-1810.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-Go/β1/γ23.182023-10-1810.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-3.182023-10-1810.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-1810.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-1810.1016/j.cell.2023.09.020
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-1810.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-1810.1016/j.cell.2023.09.020
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-1010.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-1010.1038/s41589-023-01339-w
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-Gi1/β1/γ22.92023-05-1010.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a anaphylatoxin-2.92023-05-1010.1038/s41589-023-01339-w




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