psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P43	R:R:R37	5.76	Yes	No	0	6	2
2	R:R:G38	R:R:P39	4.06	No	No	0	5	8
3	R:R:E41	R:R:G38	6.55	No	No	0	7	5
4	R:R:F40	R:R:P39	2.89	Yes	No	0	4	8
5	R:R:P39	R:R:W195	2.7	No	No	0	8	3
6	R:R:F119	R:R:F40	6.43	Yes	Yes	3	7	4
7	R:R:F40	R:R:H123	4.53	Yes	No	0	4	2
8	R:R:C126	R:R:F40	4.19	Yes	Yes	3	9	4
9	R:R:F40	R:R:P196	5.78	Yes	Yes	3	4	3
10	R:R:G42	R:R:P43	4.06	No	Yes	5	3	6
11	R:R:G42	R:R:Y118	10.14	No	No	5	3	5
12	R:R:P43	R:R:Y45	11.13	Yes	No	0	6	3
13	R:R:P43	R:R:Y118	5.56	Yes	No	5	6	5
14	R:R:R50	R:R:Y45	11.32	No	No	0	1	3
15	R:R:H46	R:R:I47	5.3	No	No	0	4	2
16	R:R:H300	R:R:I47	3.98	No	No	6	4	2
17	R:R:I47	R:R:P301	3.39	No	No	6	2	3
18	R:R:A48	R:R:Y53	2.67	No	Yes	0	3	4
19	R:R:P49	R:R:W51	10.81	No	No	0	4	2
20	R:R:H54	R:R:R50	12.41	No	No	0	4	1
21	R:R:V52	R:R:W51	7.36	No	No	0	3	2
22	R:R:V52	R:R:Y53	3.79	No	Yes	0	3	4
23	R:R:Q114	R:R:Y53	3.38	Yes	Yes	0	5	4
24	R:R:G117	R:R:Y53	5.79	No	Yes	0	4	4
25	R:R:L199	R:R:Y53	15.24	No	Yes	0	4	4
26	R:R:M60	R:R:T56	4.52	Yes	No	7	7	4
27	R:R:Q114	R:R:T56	8.5	Yes	No	7	5	4
28	R:R:S57	R:R:V111	3.23	No	No	0	6	6
29	R:R:M60	R:R:W59	3.49	Yes	No	0	7	4
30	R:R:V63	R:R:W59	8.58	No	No	0	7	4
31	R:R:F309	R:R:W59	8.02	No	No	0	5	4
32	R:R:M60	R:R:S110	6.13	Yes	No	0	7	6
33	R:R:M60	R:R:Q114	6.8	Yes	Yes	7	7	5
34	R:R:A66	R:R:F62	2.77	No	No	0	4	4
35	R:R:T103	R:R:V64	3.17	No	No	0	6	5
36	R:R:S107	R:R:V64	3.23	No	No	0	7	5
37	R:R:N71	R:R:S67	2.98	Yes	No	0	9	8
38	R:R:S67	R:R:T103	9.59	No	No	2	8	6
39	R:R:S67	R:R:T315	4.8	No	Yes	2	8	8
40	R:R:L100	R:R:V68	2.98	No	No	0	7	6
41	R:R:F69	R:R:L73	7.31	No	No	0	3	6
42	R:R:P319	R:R:T70	3.5	No	No	0	9	8
43	R:R:A96	R:R:N71	3.13	No	Yes	0	9	9
44	R:R:D99	R:R:N71	5.39	Yes	Yes	0	9	9
45	R:R:L100	R:R:N71	5.49	No	Yes	0	7	9
46	R:R:N71	R:R:P319	6.52	Yes	No	0	9	9
47	R:R:A96	R:R:V74	3.39	No	No	0	9	9
48	R:R:V323	R:R:V74	8.02	Yes	No	0	7	9
49	R:R:A96	R:R:L75	3.15	No	No	0	9	8
50	R:R:L84	R:R:T78	2.95	Yes	No	0	7	7
51	R:R:T78	R:R:V93	3.17	No	No	0	7	6
52	R:R:K80	R:R:L336	2.82	No	No	0	6	6
53	R:R:F81	R:R:L84	4.87	Yes	Yes	8	5	7
54	R:R:C332	R:R:F81	18.15	No	Yes	8	6	5
55	R:R:F81	R:R:Q335	7.03	Yes	No	0	5	5
56	R:R:F81	R:R:L336	6.09	Yes	No	0	5	6
57	R:R:K83	R:R:Q328	4.07	No	No	0	6	6
58	R:R:C332	R:R:K83	3.23	No	No	0	6	6
59	R:R:L84	R:R:Q328	5.32	Yes	No	0	7	6
60	R:R:F329	R:R:L84	10.96	Yes	Yes	0	8	7
61	R:R:C332	R:R:L84	6.35	No	Yes	8	6	7
62	R:R:H86	R:R:P87	12.2	No	No	0	8	6
63	R:R:H86	R:R:L88	7.71	No	Yes	0	8	8
64	R:R:P87	R:R:W90	5.4	No	Yes	0	6	5
65	R:R:F164	R:R:P87	2.89	Yes	No	0	6	6
66	R:R:E150	R:R:L88	7.95	No	Yes	0	8	8
67	R:R:F164	R:R:L88	9.74	Yes	Yes	0	6	8
68	R:R:F329	R:R:N89	8.46	Yes	No	0	8	9
69	R:R:A166	R:R:W90	3.89	No	Yes	0	2	5
70	R:R:A169	R:R:W90	5.19	No	Yes	0	7	5
71	R:R:I170	R:R:W90	3.52	No	Yes	0	2	5
72	R:R:I91	R:R:N94	2.83	Yes	No	0	7	9
73	R:R:I91	R:R:S143	4.64	Yes	No	0	7	8
74	R:R:I146	R:R:I91	5.89	No	Yes	0	7	7
75	R:R:I147	R:R:I91	5.89	No	Yes	0	9	7
76	R:R:E150	R:R:I91	4.1	No	Yes	0	8	7
77	R:R:L92	R:R:V323	4.47	No	Yes	0	8	7
78	R:R:I173	R:R:N94	11.33	No	No	0	7	9
79	R:R:N94	R:R:W177	7.91	No	No	0	9	9
80	R:R:D99	R:R:L95	2.71	Yes	No	2	9	9
81	R:R:L95	R:R:N318	8.24	No	No	2	9	9
82	R:R:D99	R:R:T315	11.56	Yes	Yes	2	9	8
83	R:R:D99	R:R:N318	6.73	Yes	No	2	9	9
84	R:R:C136	R:R:E102	6.08	No	Yes	0	7	7
85	R:R:E102	R:R:G137	3.27	Yes	No	0	7	7
86	R:R:E102	R:R:K312	4.05	Yes	No	1	7	7
87	L:L:?1	R:R:E102	7.93	Yes	Yes	1	0	7
88	R:R:T103	R:R:T315	4.71	No	Yes	2	6	8
89	R:R:I105	R:R:V133	3.07	No	No	0	5	6
90	R:R:A106	R:R:K312	3.21	No	No	0	6	7
91	R:R:I109	R:R:N113	2.83	No	Yes	0	5	6
92	R:R:E129	R:R:I109	16.4	No	No	0	5	5
93	R:R:F119	R:R:N113	9.67	Yes	Yes	0	7	6
94	R:R:L121	R:R:N113	5.49	Yes	Yes	0	6	6
95	R:R:N113	R:R:T201	2.92	Yes	No	0	6	5
96	R:R:Q114	R:R:T201	8.5	Yes	No	0	5	5
97	R:R:V115	R:R:Y116	7.57	No	No	0	5	4
98	R:R:V120	R:R:Y116	7.57	No	No	0	3	4
99	R:R:V120	R:R:Y118	8.83	No	No	0	3	5
100	R:R:C126	R:R:F119	2.79	Yes	Yes	3	9	7
101	R:R:C203	R:R:F119	4.19	No	Yes	3	9	7
102	R:R:L121	R:R:V120	2.98	Yes	No	0	6	3
103	R:R:L121	R:R:M125	2.83	Yes	No	0	6	6
104	R:R:H123	R:R:V127	2.77	No	No	0	2	6
105	R:R:L128	R:R:M125	2.83	No	No	0	4	6
106	R:R:C126	R:R:P196	3.77	Yes	Yes	3	9	3
107	R:R:C126	R:R:C203	7.28	Yes	No	3	9	9
108	R:R:I188	R:R:V127	3.07	No	No	0	6	6
109	R:R:L128	R:R:T132	2.95	No	No	0	4	4
110	R:R:E129	R:R:S202	2.87	No	No	0	5	5
111	R:R:G130	R:R:Y194	4.35	No	Yes	0	4	4
112	R:R:T184	R:R:Y131	8.74	No	No	0	7	6
113	R:R:Y131	R:R:Y194	3.97	No	Yes	0	6	4
114	R:R:S134	R:R:T184	3.2	No	No	0	3	7
115	R:R:S134	R:R:Y194	5.09	No	Yes	0	3	4
116	R:R:L135	R:R:T139	2.95	No	No	9	5	7
117	R:R:L135	R:R:W177	5.69	No	No	9	5	9
118	R:R:A180	R:R:I138	3.25	No	No	0	8	6
119	R:R:C227	R:R:I138	6.55	Yes	No	0	6	6
120	R:R:T139	R:R:W177	18.19	No	No	9	7	9
121	R:R:G140	R:R:S143	3.71	No	No	0	9	8
122	R:R:L141	R:R:P231	3.28	No	No	1	7	9
123	R:R:F277	R:R:L141	6.09	Yes	No	1	9	7
124	R:R:L141	R:R:W281	13.67	No	Yes	1	7	8
125	R:R:F175	R:R:W142	6.01	No	Yes	1	3	5
126	R:R:W142	R:R:W179	13.12	Yes	No	1	5	4
127	R:R:T230	R:R:W142	3.64	No	Yes	1	4	5
128	R:R:P231	R:R:W142	13.51	No	Yes	1	9	5
129	R:R:S143	R:R:S176	3.26	No	No	0	8	7
130	R:R:L144	R:R:Y322	9.38	No	Yes	0	8	9
131	R:R:A145	R:R:I235	3.25	No	No	0	7	8
132	R:R:I147	R:R:R151	6.26	No	No	0	9	9
133	R:R:I147	R:R:Y322	4.84	No	Yes	0	9	9
134	R:R:I235	R:R:S148	4.64	No	No	0	8	8
135	R:R:C238	R:R:S148	5.16	No	No	0	7	8
136	R:R:S148	R:R:Y239	15.26	No	Yes	0	8	9
137	R:R:W149	R:R:W152	3.75	No	Yes	0	6	8
138	R:R:M153	R:R:W149	6.98	No	No	0	5	6
139	R:R:R151	R:R:Y239	5.14	No	Yes	0	9	9
140	R:R:C156	R:R:W152	5.22	No	Yes	10	7	8
141	R:R:P158	R:R:W152	10.81	Yes	Yes	10	7	8
142	R:R:C238	R:R:W152	7.84	No	Yes	0	7	8
143	R:R:Q241	R:R:W152	4.38	No	Yes	0	4	8
144	R:R:V155	R:R:V242	3.21	No	No	0	8	8
145	R:R:C156	R:R:P158	3.77	No	Yes	10	7	7
146	R:R:K157	R:R:N161	2.8	No	No	0	6	7
147	R:R:F159	R:R:P158	5.78	No	Yes	0	5	7
148	R:R:D165	R:R:R163	14.29	No	No	0	7	4
149	R:R:F164	R:R:L168	4.87	Yes	No	0	6	4
150	R:R:A169	R:R:F164	2.77	No	Yes	0	7	6
151	R:R:F175	R:R:W179	13.03	No	No	1	3	4
152	R:R:W179	R:R:W183	15.93	No	Yes	1	4	5
153	R:R:V222	R:R:W183	3.68	No	Yes	0	5	5
154	R:R:T226	R:R:W183	18.19	No	Yes	1	4	5
155	R:R:C227	R:R:W183	3.92	Yes	Yes	1	6	5
156	R:R:A185	R:R:F189	2.77	No	No	0	3	5
157	R:R:P186	R:R:P187	5.84	No	No	4	6	6
158	R:R:P186	R:R:W191	9.46	No	Yes	4	6	5
159	R:R:P186	R:R:Y219	6.95	No	Yes	4	6	7
160	R:R:P187	R:R:Y194	11.13	No	Yes	0	6	4
161	R:R:P187	R:R:Y219	12.52	No	Yes	4	6	7
162	R:R:F189	R:R:I188	8.79	No	No	0	5	6
163	R:R:G215	R:R:W191	2.81	No	Yes	0	3	5
164	R:R:S218	R:R:W191	3.71	No	Yes	0	4	5
165	R:R:W191	R:R:Y219	8.68	Yes	Yes	4	5	7
166	R:R:V222	R:R:W191	3.68	No	Yes	0	5	5
167	R:R:S192	R:R:V216	4.85	No	No	0	5	5
168	R:R:S192	R:R:Y219	5.09	No	Yes	0	5	7
169	R:R:R193	R:R:W195	23.99	No	No	0	4	3
170	R:R:D206	R:R:R193	11.91	No	No	0	4	4
171	R:R:R193	R:R:Y213	12.35	No	No	0	4	2
172	R:R:P205	R:R:Y194	4.17	No	Yes	0	4	4
173	R:R:P196	R:R:W195	12.16	Yes	No	0	3	3
174	R:R:K200	R:R:P196	3.35	No	Yes	0	3	3
175	R:R:C203	R:R:P196	5.65	No	Yes	3	9	3
176	R:R:G198	R:R:H197	3.18	No	No	0	4	5
177	R:R:H197	R:R:S202	4.18	No	No	0	5	5
178	R:R:G204	R:R:H197	3.18	No	No	0	4	5
179	R:R:L199	R:R:T201	2.95	No	No	0	4	5
180	R:R:G204	R:R:P205	4.06	No	No	0	4	4
181	R:R:D206	R:R:S209	2.94	No	No	0	4	5
182	R:R:D206	R:R:S211	5.89	No	No	0	4	4
183	R:R:F208	R:R:V207	7.87	Yes	No	0	5	4
184	R:R:M220	R:R:V207	7.61	No	No	0	5	4
185	R:R:F208	R:R:Y284	3.09	Yes	Yes	1	5	7
186	R:R:F208	R:R:F287	4.29	Yes	Yes	1	5	5
187	R:R:A304	R:R:F208	5.55	No	Yes	0	4	5
188	R:R:F208	R:R:P307	4.33	Yes	Yes	1	5	6
189	R:R:P214	R:R:Y213	9.74	No	No	0	2	2
190	R:R:M220	R:R:V216	3.04	No	No	0	5	5
191	R:R:P295	R:R:Q217	7.9	No	No	0	1	4
192	R:R:L223	R:R:Y219	4.69	No	Yes	0	5	7
193	R:R:A292	R:R:M220	3.22	No	No	0	4	5
194	R:R:C227	R:R:L223	3.17	Yes	No	0	6	5
195	L:L:?1	R:R:L223	5.52	Yes	No	0	0	5
196	R:R:I229	R:R:M224	2.92	No	Yes	0	4	5
197	R:R:C289	R:R:M224	3.24	No	Yes	0	6	5
198	L:L:?1	R:R:M224	6.58	Yes	Yes	0	0	5
199	R:R:C227	R:R:T226	3.38	Yes	No	1	6	4
200	L:L:?1	R:R:C228	6.33	Yes	No	0	0	7
201	R:R:P231	R:R:T230	3.5	No	No	1	9	4
202	R:R:L232	R:R:V236	2.98	No	No	0	6	5
203	R:R:F277	R:R:L232	4.87	Yes	No	0	9	6
204	R:R:V270	R:R:Y239	3.79	No	Yes	0	8	9
205	R:R:M273	R:R:Y239	9.58	No	Yes	0	8	9
206	R:R:L240	R:R:L244	4.15	No	No	0	3	1
207	R:R:L244	R:R:W243	3.42	No	No	0	1	6
208	R:R:R247	R:R:W243	12	No	No	0	5	6
209	R:R:T267	R:R:W243	7.28	No	No	0	7	6
210	R:R:E263	R:R:R247	5.82	No	No	0	7	5
211	R:R:Q252	R:R:V249	10.03	No	No	0	4	6
212	R:R:A250	R:R:Q260	4.55	No	No	0	4	4
213	R:R:A250	R:R:E263	4.53	No	No	0	4	7
214	R:R:Q252	R:R:Q253	11.52	No	No	0	4	5
215	R:R:K254	R:R:Q260	8.14	No	No	0	4	4
216	R:R:S256	R:R:T259	6.4	No	No	0	5	4
217	R:R:M269	R:R:M325	2.89	No	No	11	8	7
218	R:R:L275	R:R:V271	2.98	No	No	0	4	5
219	R:R:I321	R:R:V272	3.07	Yes	No	0	8	6
220	R:R:M273	R:R:Y322	9.58	No	Yes	0	8	9
221	R:R:F277	R:R:W281	6.01	Yes	Yes	1	9	8
222	R:R:F279	R:R:F310	5.36	No	No	0	5	7
223	R:R:C280	R:R:W281	11.75	No	Yes	0	9	8
224	R:R:C280	R:R:Y317	2.69	No	No	0	9	6
225	R:R:A311	R:R:W281	3.89	No	Yes	0	7	8
226	L:L:?1	R:R:W281	4.54	Yes	Yes	1	0	8
227	R:R:G282	R:R:P283	4.06	No	No	0	4	9
228	R:R:P283	R:R:P307	3.9	No	Yes	0	9	6
229	R:R:F310	R:R:P283	5.78	No	No	0	7	9
230	R:R:P307	R:R:Y284	9.74	Yes	Yes	1	6	7
231	L:L:?1	R:R:Y284	7.02	Yes	Yes	1	0	7
232	R:R:F286	R:R:F287	10.72	No	Yes	0	5	5
233	R:R:F287	R:R:F299	3.22	Yes	Yes	1	5	3
234	R:R:F287	R:R:M303	4.98	Yes	No	0	5	4
235	R:R:F287	R:R:P307	7.22	Yes	Yes	1	5	6
236	R:R:F290	R:R:N294	6.04	No	No	0	3	3
237	R:R:F290	R:R:Y297	10.32	No	No	1	3	2
238	R:R:F290	R:R:F299	4.29	No	Yes	1	3	3
239	R:R:A291	R:R:F299	2.77	No	Yes	0	4	3
240	R:R:A293	R:R:N294	3.13	No	No	0	5	3
241	R:R:P298	R:R:Y297	6.95	No	No	0	1	2
242	R:R:F299	R:R:Y297	4.13	Yes	No	1	3	2
243	R:R:H300	R:R:P301	12.2	No	No	6	4	3
244	R:R:H300	R:R:L302	7.71	No	No	0	4	1
245	R:R:F309	R:R:F310	7.5	No	No	0	5	7
246	L:L:?1	R:R:K312	9.38	Yes	No	1	0	7
247	R:R:S313	R:R:Y317	7.63	No	No	0	5	6
248	R:R:A314	R:R:Y317	2.67	No	No	0	9	6
249	R:R:A314	R:R:N318	4.69	No	No	0	9	9
250	R:R:I316	R:R:T315	3.04	No	Yes	0	7	8
251	R:R:P319	R:R:V323	3.53	No	Yes	0	9	7
252	R:R:F324	R:R:V320	3.93	Yes	No	0	6	6
253	R:R:I321	R:R:Y322	6.04	Yes	Yes	0	8	9
254	R:R:F324	R:R:V323	3.93	Yes	Yes	0	6	7
255	R:R:F329	R:R:V323	6.55	Yes	Yes	0	8	7
256	R:R:F329	R:R:N326	6.04	Yes	No	0	8	8
257	R:R:H46	R:R:N44	2.55	No	No	0	4	5
258	R:R:F277	R:R:I235	2.51	Yes	No	0	9	8
259	R:R:F324	R:R:I333	2.51	Yes	No	0	6	6
260	R:R:K82	R:R:R85	2.48	No	No	0	6	8
261	R:R:M325	R:R:R330	2.48	No	No	0	7	8
262	R:R:V242	R:R:W152	2.45	No	Yes	0	8	8
263	R:R:F324	R:R:L73	2.44	Yes	No	0	6	6
264	R:R:L334	R:R:R330	2.43	No	No	0	4	8
265	R:R:I234	R:R:W142	2.35	No	Yes	0	5	5
266	R:R:G210	R:R:G296	2.11	No	No	0	1	1
267	L:L:?1	R:R:A288	2.1	Yes	No	0	0	5
268	R:R:G122	R:R:P124	2.03	No	No	0	8	1
269	R:R:A305	R:R:G198	1.95	No	No	0	4	4
270	R:R:G210	R:R:S209	1.86	No	No	0	1	5
271	R:R:G172	R:R:V171	1.84	No	No	0	5	2
272	R:R:A101	R:R:C136	1.81	No	No	0	5	7
273	R:R:A245	R:R:C156	1.81	No	No	0	6	7
274	R:R:G172	R:R:I146	1.76	No	No	0	5	7
275	R:R:G160	R:R:K157	1.74	No	No	0	4	6
276	R:R:C278	R:R:V274	1.71	No	No	0	6	8
277	R:R:A250	R:R:T259	1.68	No	No	0	4	4
278	R:R:K157	R:R:P158	1.67	No	Yes	0	6	7
279	R:R:L306	R:R:P307	1.64	No	Yes	0	4	6
280	R:R:S256	R:R:S258	1.63	No	No	0	5	4
281	R:R:N294	R:R:P295	1.63	No	No	0	3	1
282	R:R:A66	R:R:I316	1.62	No	No	0	4	7
283	R:R:A77	R:R:I333	1.62	No	No	0	7	6
284	R:R:S134	R:R:V133	1.62	No	No	0	3	6
285	R:R:A276	R:R:I321	1.62	No	Yes	0	6	8
286	R:R:A76	R:R:M79	1.61	No	No	0	3	3
287	R:R:A285	R:R:M224	1.61	No	Yes	0	6	5
288	R:R:V93	R:R:V97	1.6	No	No	0	6	7
289	R:R:V270	R:R:V274	1.6	No	No	0	8	8
290	R:R:T108	R:R:V104	1.59	No	No	0	7	4
291	R:R:T259	R:R:V249	1.59	No	No	0	4	6
292	R:R:A48	R:R:L302	1.58	No	No	0	3	1
293	R:R:A181	R:R:L135	1.58	No	No	0	3	5
294	R:R:I61	R:R:V111	1.54	No	No	0	4	6
295	R:R:I246	R:R:V155	1.54	No	No	0	8	8
296	R:R:A166	R:R:D165	1.54	No	No	0	2	7
297	R:R:I229	R:R:V225	1.54	No	No	0	4	4
298	R:R:I246	R:R:V266	1.54	No	No	0	8	8
299	R:R:H123	R:R:P124	1.53	No	No	0	2	1
300	R:R:L88	R:R:V154	1.49	Yes	No	0	8	8
301	R:R:L121	R:R:V112	1.49	Yes	No	0	6	5
302	R:R:I61	R:R:I65	1.47	No	No	0	4	4
303	R:R:I321	R:R:M269	1.46	Yes	No	11	8	8
304	R:R:I321	R:R:M325	1.46	Yes	No	11	8	7
305	R:R:Q114	R:R:S57	1.44	Yes	No	0	5	6
306	R:R:D165	R:R:K167	1.38	No	No	0	7	4
307	R:R:E263	R:R:I246	1.37	No	No	0	7	8
308	R:R:A308	R:R:Y284	1.33	No	Yes	0	5	7
309	R:R:F159	R:R:V162	1.31	No	No	0	5	4
310	R:R:E265	R:R:R268	1.16	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F40	4.764	5	3	4
2	R:R:P43	6.6275	4	5	6
3	R:R:Y53	6.174	5	0	4
4	R:R:M60	5.235	4	7	7
5	R:R:N71	4.702	5	0	9
6	R:R:F81	9.035	4	8	5
7	R:R:L84	6.09	5	8	7
8	R:R:L88	6.7225	4	0	8
9	R:R:W90	4.5	4	0	5
10	R:R:I91	4.67	5	0	7
11	R:R:D99	6.5975	4	2	9
12	R:R:E102	5.3325	4	1	7
13	R:R:N113	5.2275	4	0	6
14	R:R:Q114	5.724	5	7	5
15	R:R:F119	5.77	4	3	7
16	R:R:L121	3.1975	4	0	6
17	R:R:C126	4.5075	4	3	9
18	R:R:W142	7.726	5	1	5
19	R:R:W152	5.74167	6	10	8
20	R:R:P158	5.5075	4	10	7
21	R:R:F164	5.0675	4	0	6
22	R:R:W183	10.43	4	1	5
23	R:R:W191	5.668	5	4	5
24	R:R:Y194	5.742	5	0	4
25	R:R:P196	6.142	5	3	3
26	R:R:F208	5.026	5	1	5
27	R:R:Y219	7.586	5	4	7
28	R:R:M224	3.5875	4	0	5
29	R:R:C227	4.255	4	1	6
30	R:R:Y239	8.4425	4	0	9
31	R:R:F277	4.87	4	1	9
32	R:R:W281	7.972	5	1	8
33	R:R:Y284	5.295	4	1	7
34	R:R:F287	6.086	5	1	5
35	R:R:F299	3.6025	4	1	3
36	R:R:P307	5.366	5	1	6
37	R:R:T315	6.0275	4	2	8
38	R:R:I321	2.73	5	11	8
39	R:R:Y322	7.46	4	0	9
40	R:R:V323	5.3	5	0	7
41	R:R:F324	3.2025	4	0	6
42	R:R:F329	8.0025	4	0	8
43	L:L:?1	6.175	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:P39	13.4338	2.89	Yes	No	0	4	8
2	R:R:F119	R:R:F40	33.6859	6.43	Yes	Yes	3	7	4
3	R:R:F119	R:R:N113	60.5348	9.67	Yes	Yes	0	7	6
4	R:R:L121	R:R:N113	18.5606	5.49	Yes	Yes	0	6	6
5	R:R:L121	R:R:V120	12.56	2.98	Yes	No	0	6	3
6	R:R:P39	R:R:W195	10.1485	2.7	No	No	0	8	3
7	R:R:F40	R:R:P196	12.3275	5.78	Yes	Yes	3	4	3
8	R:R:P196	R:R:W195	29.8005	12.16	Yes	No	0	3	3
9	R:R:C126	R:R:F119	13.0213	2.79	Yes	Yes	3	9	7
10	R:R:C126	R:R:P196	11.9749	3.77	Yes	Yes	3	9	3
11	R:R:C203	R:R:F119	13.0251	4.19	No	Yes	3	9	7
12	R:R:C203	R:R:P196	12.0537	5.65	No	Yes	3	9	3
13	R:R:A48	R:R:Y53	10.6286	2.67	No	Yes	0	3	4
14	R:R:Q114	R:R:Y53	14.6377	3.38	Yes	Yes	0	5	4
15	R:R:Q114	R:R:T201	59.7435	8.5	Yes	No	0	5	5
16	R:R:N113	R:R:T201	62.9388	2.92	Yes	No	0	6	5
17	R:R:M60	R:R:Q114	67.758	6.8	Yes	Yes	7	7	5
18	R:R:M60	R:R:W59	69.2844	3.49	Yes	No	0	7	4
19	R:R:F309	R:R:W59	70.0795	8.02	No	No	0	5	4
20	R:R:D99	R:R:N318	44.3107	6.73	Yes	No	2	9	9
21	R:R:A314	R:R:N318	46.3171	4.69	No	No	0	9	9
22	R:R:A314	R:R:Y317	47.2322	2.67	No	No	0	9	6
23	R:R:C280	R:R:Y317	49.0399	2.69	No	No	0	9	6
24	R:R:C280	R:R:W281	49.9325	11.75	No	Yes	0	9	8
25	L:L:?1	R:R:W281	100	4.54	Yes	Yes	1	0	8
26	L:L:?1	R:R:Y284	87.365	7.02	Yes	Yes	1	0	7
27	R:R:P307	R:R:Y284	74.835	9.74	Yes	Yes	1	6	7
28	R:R:P283	R:R:P307	72.2097	3.9	No	Yes	0	9	6
29	R:R:F310	R:R:P283	71.3621	5.78	No	No	0	7	9
30	R:R:F309	R:R:F310	70.5295	7.5	No	No	0	5	7
31	R:R:D99	R:R:N71	35.261	5.39	Yes	Yes	0	9	9
32	R:R:P319	R:R:V323	26.4476	3.53	No	Yes	0	9	7
33	R:R:N71	R:R:P319	28.5779	6.52	Yes	No	0	9	9
34	R:R:F329	R:R:L84	14.4127	10.96	Yes	Yes	0	8	7
35	R:R:F329	R:R:V323	17.8068	6.55	Yes	Yes	0	8	7
36	R:R:E150	R:R:L88	29.6842	7.95	No	Yes	0	8	8
37	R:R:E150	R:R:I91	30.7418	4.1	No	Yes	0	8	7
38	R:R:I147	R:R:I91	43.7144	5.89	No	Yes	0	9	7
39	R:R:I147	R:R:R151	43.2118	6.26	No	No	0	9	9
40	R:R:R151	R:R:Y239	44.0819	5.14	No	Yes	0	9	9
41	R:R:S148	R:R:Y239	57.9208	15.26	No	Yes	0	8	9
42	R:R:I235	R:R:S148	81.0681	4.64	No	No	0	8	8
43	R:R:F277	R:R:I235	82.2157	2.51	Yes	No	0	9	8
44	R:R:F277	R:R:W281	80.7081	6.01	Yes	Yes	1	9	8
45	R:R:F164	R:R:L88	18.3843	9.74	Yes	Yes	0	6	8
46	R:R:P87	R:R:W90	13.8314	5.4	No	Yes	0	6	5
47	R:R:A166	R:R:W90	13.7864	3.89	No	Yes	0	2	5
48	R:R:P205	R:R:Y194	19.1757	4.17	No	Yes	0	4	4
49	R:R:G204	R:R:P205	18.6994	4.06	No	No	0	4	4
50	R:R:G204	R:R:H197	18.2006	3.18	No	No	0	4	5
51	R:R:H197	R:R:S202	16.8129	4.18	No	No	0	5	5
52	R:R:E129	R:R:S202	16.3966	2.87	No	No	0	5	5
53	R:R:E129	R:R:I109	16.1304	16.4	No	No	0	5	5
54	R:R:I109	R:R:N113	15.8266	2.83	No	Yes	0	5	6
55	R:R:L223	R:R:Y219	21.8872	4.69	No	Yes	0	5	7
56	R:R:P187	R:R:Y219	19.7607	12.52	No	Yes	4	6	7
57	R:R:P187	R:R:Y194	22.851	11.13	No	Yes	0	6	4
58	R:R:M273	R:R:Y239	10.4635	9.58	No	Yes	0	8	9
59	R:R:C238	R:R:S148	35.8498	5.16	No	No	0	7	8
60	R:R:C238	R:R:W152	34.8372	7.84	No	Yes	0	7	8
61	R:R:V242	R:R:W152	22.2285	2.45	No	Yes	0	8	8
62	R:R:V155	R:R:V242	21.1184	3.21	No	No	0	8	8
63	R:R:A166	R:R:D165	10.2873	1.54	No	No	0	2	7
64	R:R:R193	R:R:W195	35.5198	23.99	No	No	0	4	3
65	R:R:D206	R:R:R193	22.2547	11.91	No	No	0	4	4
66	R:R:D206	R:R:S209	13.3738	2.94	No	No	0	4	5
67	R:R:F287	R:R:P307	13.3963	7.22	Yes	Yes	1	5	6
68	R:R:F287	R:R:F299	17.0005	3.22	Yes	Yes	1	5	3
69	R:R:E263	R:R:I246	17.7993	1.37	No	No	0	7	8
70	R:R:I246	R:R:V155	19.9932	1.54	No	No	0	8	8
71	R:R:A250	R:R:E263	10.9248	4.53	No	No	0	4	7
72	L:L:?1	R:R:L223	24.5162	5.52	Yes	No	0	0	5
73	R:R:F208	R:R:Y284	12.0762	3.09	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C136	R:R:E102	6.08	0	No	Yes	7	7	2	1
R:R:E102	R:R:G137	3.27	1	Yes	No	7	7	1	2
R:R:E102	R:R:K312	4.05	1	Yes	No	7	7	1	1
L:L:?1	R:R:E102	7.93	1	Yes	Yes	0	7	0	1
R:R:A106	R:R:K312	3.21	0	No	No	6	7	2	1
R:R:F277	R:R:L141	6.09	1	Yes	No	9	7	2	2
R:R:L141	R:R:W281	13.67	1	No	Yes	7	8	2	1
R:R:F208	R:R:Y284	3.09	1	Yes	Yes	5	7	2	1
R:R:F208	R:R:P307	4.33	1	Yes	Yes	5	6	2	2
R:R:L223	R:R:Y219	4.69	0	No	Yes	5	7	1	2
R:R:C227	R:R:L223	3.17	1	Yes	No	6	5	2	1
L:L:?1	R:R:L223	5.52	1	Yes	No	0	5	0	1
R:R:I229	R:R:M224	2.92	0	No	Yes	4	5	2	1
R:R:C289	R:R:M224	3.24	0	No	Yes	6	5	2	1
L:L:?1	R:R:M224	6.58	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:C228	6.33	1	Yes	No	0	7	0	1
R:R:F277	R:R:W281	6.01	1	Yes	Yes	9	8	2	1
R:R:C280	R:R:W281	11.75	0	No	Yes	9	8	2	1
R:R:A311	R:R:W281	3.89	0	No	Yes	7	8	2	1
L:L:?1	R:R:W281	4.54	1	Yes	Yes	0	8	0	1
R:R:P307	R:R:Y284	9.74	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y284	7.02	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:K312	9.38	1	Yes	No	0	7	0	1
L:L:?1	R:R:A288	2.1	1	Yes	No	0	5	0	1
R:R:A285	R:R:M224	1.61	0	No	Yes	6	5	2	1
R:R:A308	R:R:Y284	1.33	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9YDA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.67
Number of Linked Nodes	280
Number of Links	310
Number of Hubs	43
Number of Links mediated by Hubs	164
Number of Communities	11
Number of Nodes involved in Communities	57
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	53917
Length Of Smallest Path	3
Average Path Length	16.4218
Length of Longest Path	36
Minimum Path Strength	1.46
Average Path Strength	6.12082
Maximum Path Strength	18.17
Minimum Path Correlation	0.7
Average Path Correlation	0.927873
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	44.5286
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6273
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • identical protein binding • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • detection of light stimulus • response to light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • absorption of visible light • detection of stimulus • light absorption • response to abiotic stimulus • response to radiation • cellular response to light stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • sensory perception of light stimulus • visual perception • phototransduction
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P04001
Sequence	>9YDA_nogp_Chain_R R G P F E G P N Y H I A P R W V Y H L T S V W M I F V V I A S V F T N G L V L A A T M K F K K L R H P L N W I L V N L A V A D L A E T V I A S T I S V V N Q V Y G Y F V L G H P M C V L E G Y T V S L C G I T G L W S L A I I S W E R W M V V C K P F G N V R F D A K L A I V G I A F S W I W A A V W T A P P I F G W S R Y W P H G L K T S C G P D V F S G S S Y P G V Q S Y M I V L M V T C C I T P L S I I V L C Y L Q V W L A I R A V A K Q Q K E S E S T Q K A E K E V T R M V V V M V L A F C F C W G P Y A F F A C F A A A N P G Y P F H P L M A A L P A F F A K S A T I Y N P V I Y V F M N R Q F R N C I L Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y01	A	Sensory	Opsins	Opsin1MW	Homo sapiens	All-trans-Retinal	-	Gi1/β1/γ2	2.48	2025-02-12	To be published
	8Y01 (No Gprot)	A	Sensory	Opsins	Opsin1MW	Homo sapiens	All-trans-Retinal	-		2.48	2025-02-12	To be published
	9YDA	A	Sensory	Opsins	Opsin1MW	Homo sapiens	All-trans-Retinal	-	chim(NtGi1L-Gs-CtGt)/β1/γ2	2.9	2025-12-24	10.1073/pnas.2516318122
	9YDA (No Gprot)	A	Sensory	Opsins	Opsin1MW	Homo sapiens	All-trans-Retinal	-		2.9	2025-12-24	10.1073/pnas.2516318122

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Download 9YDA_nogp.zip

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