psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
2	L:L:H1	R:R:H234	3.58	Yes	Yes	0	0	7
3	L:L:H1	R:R:V237	9.69	Yes	No	0	0	6
4	L:L:H1	R:R:W306	5.29	Yes	Yes	0	0	5
5	L:L:S2	R:R:E385	10.06	No	No	0	0	8
6	L:L:S2	R:R:L386	3	No	Yes	0	0	8
7	L:L:D3	R:R:Y161	6.9	Yes	Yes	1	0	7
8	L:L:D3	R:R:V203	2.92	Yes	Yes	1	0	7
9	L:L:D3	R:R:F233	3.58	Yes	Yes	1	0	6
10	L:L:D3	R:R:L386	6.79	Yes	Yes	1	0	8
11	L:L:I5	R:R:K378	4.36	No	No	0	0	5
12	L:L:I5	R:R:R381	5.01	No	No	0	0	7
13	L:L:F6	L:L:Y10	4.13	Yes	Yes	0	0	0
14	L:L:F6	R:R:V153	5.24	Yes	No	1	0	6
15	L:L:F6	R:R:Y157	7.22	Yes	Yes	1	0	8
16	L:L:F6	R:R:L382	3.65	Yes	No	0	0	5
17	L:L:F6	R:R:L386	3.65	Yes	Yes	1	0	8
18	L:L:T7	R:R:K206	7.51	No	No	0	0	6
19	L:L:T7	R:R:Y211	3.75	No	Yes	0	0	4
20	L:L:D8	L:L:R12	11.91	No	No	0	0	0
21	L:L:D8	R:R:N300	6.73	No	No	0	0	6
22	L:L:S9	R:R:Y150	7.63	No	Yes	0	0	4
23	L:L:S9	R:R:K378	6.12	No	No	0	0	5
24	L:L:Y10	R:R:Y150	9.93	Yes	Yes	0	0	4
25	L:L:Y10	R:R:K154	5.97	Yes	No	0	0	5
26	L:L:Y10	R:R:Y211	13.9	Yes	Yes	0	0	4
27	L:L:S11	R:R:D298	11.78	No	No	0	0	6
28	L:L:M17	L:L:Y13	3.59	No	No	0	0	0
29	L:L:Y13	R:R:Q146	9.02	No	No	0	0	1
30	L:L:Y13	R:R:D147	6.9	No	No	0	0	1
31	L:L:R14	R:R:Y211	13.38	No	Yes	0	0	4
32	L:L:K15	R:R:I83	2.91	No	No	0	0	4
33	L:L:K15	R:R:M299	2.88	No	No	0	0	5
34	L:L:Q16	R:R:I83	5.49	No	No	0	0	4
35	L:L:V26	L:L:Y22	5.05	No	No	0	0	0
36	L:L:Y22	R:R:F27	12.38	No	No	0	0	6
37	L:L:L27	L:L:V26	2.98	No	No	0	0	0
38	L:L:V26	R:R:N60	2.96	No	No	0	0	6
39	R:R:E30	R:R:W58	10.9	No	Yes	0	7	7
40	R:R:Q31	R:R:W58	17.52	No	Yes	0	4	7
41	R:R:C34	R:R:K37	3.23	No	No	0	9	4
42	R:R:C34	R:R:W58	5.22	No	Yes	4	9	7
43	R:R:C34	R:R:C63	7.28	No	No	4	9	9
44	R:R:K37	R:R:R40	3.71	No	No	0	4	5
45	R:R:K37	R:R:K65	4.31	No	No	0	4	7
46	R:R:G56	R:R:I38	3.53	No	No	0	5	6
47	R:R:Q39	R:R:R40	3.5	No	No	0	4	5
48	R:R:A41	R:R:P66	3.74	No	Yes	0	4	4
49	R:R:N42	R:R:P55	3.26	No	No	0	2	4
50	R:R:G56	R:R:N42	3.39	No	No	5	5	2
51	R:R:N42	R:R:P66	11.4	No	Yes	5	2	4
52	R:R:M45	R:R:P52	3.35	No	No	0	2	1
53	R:R:P52	R:R:P66	5.84	No	Yes	0	1	4
54	R:R:C118	R:R:C54	5.46	No	No	0	9	9
55	R:R:C54	R:R:W123	18.28	No	Yes	0	9	9
56	R:R:G56	R:R:P66	6.09	No	Yes	5	5	4
57	R:R:M57	R:R:W123	16.29	No	Yes	0	6	9
58	R:R:C63	R:R:W58	7.84	No	Yes	4	9	7
59	R:R:D59	R:R:T62	5.78	No	Yes	2	9	5
60	R:R:D59	R:R:W64	12.28	No	Yes	2	9	9
61	R:R:D59	R:R:Y130	3.45	No	Yes	2	9	8
62	R:R:I61	R:R:T62	4.56	Yes	Yes	2	4	5
63	R:R:I61	R:R:Y130	7.25	Yes	Yes	2	4	8
64	R:R:T62	R:R:V75	3.17	Yes	No	2	5	6
65	R:R:P78	R:R:T62	8.74	No	Yes	0	9	5
66	R:R:T62	R:R:Y130	17.48	Yes	Yes	2	5	8
67	R:R:V73	R:R:W64	4.9	No	Yes	0	8	9
68	R:R:V75	R:R:W64	3.68	No	Yes	2	6	9
69	R:R:V114	R:R:W64	3.68	Yes	Yes	2	6	9
70	R:R:R116	R:R:W64	25.99	No	Yes	2	9	9
71	R:R:W123	R:R:W64	4.69	Yes	Yes	2	9	9
72	R:R:W64	R:R:Y130	9.65	Yes	Yes	2	9	8
73	R:R:A67	R:R:E71	3.02	No	No	0	8	3
74	R:R:H68	R:R:V69	4.15	No	No	0	2	6
75	R:R:E120	R:R:V69	7.13	No	No	0	1	6
76	R:R:M72	R:R:N117	5.61	No	No	0	4	4
77	R:R:L74	R:R:S115	6.01	No	No	0	4	5
78	R:R:V75	R:R:Y130	3.79	No	Yes	2	6	8
79	R:R:M111	R:R:S76	4.6	No	No	0	3	4
80	R:R:S76	R:R:V113	3.23	No	No	0	4	1
81	R:R:C77	R:R:F81	4.19	No	Yes	2	9	6
82	R:R:C77	R:R:Y130	4.03	No	Yes	2	9	8
83	R:R:C134	R:R:C77	7.28	No	No	2	9	9
84	R:R:E79	R:R:L80	3.98	No	No	0	2	5
85	R:R:F81	R:R:R82	3.21	Yes	No	0	6	4
86	R:R:F81	R:R:M111	6.22	Yes	No	0	6	3
87	R:R:C134	R:R:F81	4.19	No	Yes	2	9	6
88	R:R:F84	R:R:N85	15.71	No	No	0	5	3
89	R:R:F131	R:R:F84	11.79	No	No	0	4	5
90	R:R:N85	R:R:Q88	15.85	No	No	0	3	3
91	R:R:D87	R:R:Q88	10.44	No	No	0	2	3
92	R:R:G112	R:R:M111	3.49	No	No	0	6	3
93	R:R:V114	R:R:Y130	17.66	Yes	Yes	2	6	8
94	R:R:F127	R:R:S115	7.93	No	No	0	3	5
95	R:R:R116	R:R:W123	6	No	Yes	2	9	9
96	R:R:P126	R:R:R116	18.74	No	No	0	5	9
97	R:R:N117	R:R:S124	2.98	No	No	0	4	6
98	R:R:D121	R:R:T119	4.34	No	No	0	4	6
99	R:R:S124	R:R:T119	4.8	No	No	0	6	6
100	R:R:E125	R:R:P126	7.86	No	No	0	4	5
101	R:R:F127	R:R:P128	18.78	No	No	0	3	4
102	R:R:D132	R:R:H129	21.43	No	No	0	6	2
103	R:R:Q146	R:R:Y150	4.51	No	Yes	1	1	4
104	R:R:Q146	R:R:R379	4.67	No	No	1	1	4
105	R:R:Y149	R:R:Y150	7.94	Yes	Yes	1	4	4
106	R:R:V153	R:R:Y149	5.05	No	Yes	1	6	4
107	R:R:R379	R:R:Y149	11.32	No	Yes	1	4	4
108	R:R:R379	R:R:Y150	5.14	No	Yes	1	4	4
109	R:R:L386	R:R:V153	2.98	Yes	No	1	8	6
110	R:R:K154	R:R:Y157	3.58	No	Yes	0	5	8
111	R:R:G387	R:R:L156	3.42	No	No	0	5	6
112	R:R:Y157	R:R:Y161	3.97	Yes	Yes	1	8	7
113	R:R:V203	R:R:Y157	5.05	Yes	Yes	1	7	8
114	R:R:D207	R:R:Y157	9.2	No	Yes	0	7	8
115	R:R:L386	R:R:Y157	4.69	Yes	Yes	1	8	8
116	R:R:G160	R:R:S390	3.71	No	No	0	9	9
117	R:R:F391	R:R:G160	4.52	No	No	0	7	9
118	R:R:R199	R:R:Y161	4.12	Yes	Yes	1	8	7
119	R:R:V203	R:R:Y161	7.57	Yes	Yes	1	7	7
120	R:R:S390	R:R:Y161	11.45	No	Yes	0	9	7
121	R:R:G393	R:R:S164	3.71	No	No	0	9	9
122	R:R:L165	R:R:M197	4.24	No	No	0	7	7
123	R:R:F394	R:R:T167	7.78	No	No	0	5	7
124	R:R:A397	R:R:T167	3.36	No	No	0	9	7
125	R:R:F193	R:R:L168	6.09	No	Yes	0	8	9
126	R:R:F196	R:R:L168	3.65	Yes	Yes	0	8	9
127	R:R:A397	R:R:L168	3.15	No	Yes	0	9	9
128	R:R:M197	R:R:T169	3.01	No	No	0	7	4
129	R:R:F402	R:R:T170	5.19	No	No	0	8	5
130	R:R:A171	R:R:C401	3.61	No	Yes	6	9	9
131	R:R:A171	R:R:F402	4.16	No	No	6	9	8
132	R:R:M172	R:R:M190	2.89	No	No	0	6	6
133	R:R:M172	R:R:V194	3.04	No	No	0	6	4
134	R:R:L175	R:R:N186	8.24	No	No	0	8	9
135	R:R:C401	R:R:L175	3.17	Yes	No	0	9	8
136	R:R:C176	R:R:M190	6.48	No	No	0	4	6
137	R:R:C183	R:R:R185	4.18	No	No	0	8	9
138	R:R:C183	R:R:N186	4.72	No	No	0	8	9
139	R:R:F266	R:R:T184	7.78	Yes	No	0	6	7
140	R:R:H189	R:R:R185	3.39	No	No	0	9	9
141	R:R:F187	R:R:F266	9.65	No	Yes	0	6	6
142	R:R:I188	R:R:Y250	8.46	No	Yes	3	9	8
143	R:R:F266	R:R:I188	6.28	Yes	No	3	6	9
144	R:R:I188	R:R:Y269	3.63	No	Yes	3	9	7
145	R:R:E247	R:R:H189	7.39	No	No	0	9	9
146	R:R:H189	R:R:Y400	4.36	No	Yes	0	9	9
147	R:R:N191	R:R:W243	19.21	No	Yes	7	8	9
148	R:R:N191	R:R:W274	10.17	No	Yes	7	8	8
149	R:R:L192	R:R:W243	7.97	No	Yes	0	9	9
150	R:R:S195	R:R:S239	3.26	No	No	0	9	8
151	R:R:N240	R:R:S195	5.96	No	No	0	9	9
152	R:R:F196	R:R:N240	10.87	Yes	No	0	8	9
153	R:R:F196	R:R:G393	4.52	Yes	No	0	8	9
154	R:R:F196	R:R:V396	3.93	Yes	No	0	8	9
155	R:R:C236	R:R:L198	6.35	No	No	0	5	7
156	R:R:R199	R:R:V237	5.23	Yes	No	0	8	6
157	R:R:N240	R:R:R199	9.64	No	Yes	0	9	8
158	R:R:R199	R:R:Y241	8.23	Yes	Yes	1	8	7
159	R:R:R199	R:R:Y366	3.09	Yes	Yes	1	8	8
160	R:R:F232	R:R:S202	7.93	No	No	1	4	6
161	R:R:F233	R:R:S202	5.28	Yes	No	1	6	6
162	R:R:C236	R:R:S202	5.16	No	No	1	5	6
163	R:R:F233	R:R:V203	3.93	Yes	Yes	1	6	7
164	R:R:I205	R:R:V229	3.07	No	No	0	6	6
165	R:R:D207	R:R:K206	8.3	No	No	0	7	6
166	R:R:F233	R:R:K206	8.69	Yes	No	0	6	6
167	R:R:D207	R:R:Y211	5.75	No	Yes	0	7	4
168	R:R:I209	R:R:W208	5.87	No	No	0	5	4
169	R:R:E225	R:R:I209	4.1	No	No	0	5	5
170	R:R:I209	R:R:V229	4.61	No	No	0	5	6
171	R:R:L210	R:R:Y211	4.69	Yes	Yes	0	7	4
172	R:R:C226	R:R:L210	3.17	No	Yes	8	9	7
173	R:R:L210	R:R:M230	4.24	Yes	No	0	7	6
174	R:R:C296	R:R:L210	3.17	No	Yes	8	9	7
175	R:R:D298	R:R:L210	8.14	No	Yes	0	6	7
176	R:R:C226	R:R:C296	7.28	No	No	8	9	9
177	R:R:D293	R:R:K227	6.91	No	No	9	6	7
178	R:R:K227	R:R:W297	20.89	No	Yes	9	7	8
179	R:R:C236	R:R:F232	4.19	No	No	1	5	4
180	R:R:F233	R:R:H234	6.79	Yes	Yes	1	6	7
181	R:R:F233	R:R:V237	3.93	Yes	No	0	6	6
182	R:R:H234	R:R:W284	10.58	Yes	Yes	1	7	8
183	R:R:H234	R:R:I309	7.95	Yes	No	1	7	7
184	R:R:W274	R:R:Y235	4.82	Yes	No	0	8	9
185	R:R:T278	R:R:Y235	4.99	No	No	0	4	9
186	R:R:V281	R:R:Y235	3.79	No	No	0	7	9
187	R:R:P277	R:R:V238	5.3	No	No	0	9	6
188	R:R:V238	R:R:V313	4.81	No	No	0	6	7
189	R:R:S239	R:R:W274	7.41	No	Yes	0	8	8
190	R:R:P277	R:R:S239	3.56	No	No	0	9	8
191	R:R:V313	R:R:Y241	12.62	No	Yes	0	7	7
192	R:R:I317	R:R:Y241	3.63	No	Yes	1	7	7
193	R:R:Y241	R:R:Y366	17.87	Yes	Yes	1	7	8
194	R:R:F242	R:R:T276	6.49	Yes	No	0	5	4
195	R:R:F242	R:R:P277	5.78	Yes	No	0	5	9
196	R:R:F242	R:R:P312	4.33	Yes	No	0	5	9
197	R:R:F242	R:R:S316	3.96	Yes	No	0	5	7
198	R:R:W243	R:R:W274	3.75	Yes	Yes	7	9	8
199	R:R:L244	R:R:Q392	3.99	No	No	0	9	9
200	R:R:F245	R:R:S316	3.96	No	No	0	8	7
201	R:R:F245	R:R:V319	5.24	No	No	0	8	6
202	R:R:I246	R:R:Y269	4.84	No	Yes	0	8	7
203	R:R:I246	R:R:I272	4.42	No	No	0	8	6
204	R:R:E247	R:R:L361	13.25	No	No	0	9	9
205	R:R:E247	R:R:F362	3.5	No	Yes	0	9	9
206	R:R:F362	R:R:G248	6.02	Yes	No	0	9	9
207	R:R:L249	R:R:T253	2.95	No	No	0	6	7
208	R:R:L254	R:R:Y250	4.69	No	Yes	0	7	8
209	R:R:F266	R:R:Y250	7.22	Yes	Yes	3	6	8
210	R:R:Y250	R:R:Y269	8.94	Yes	Yes	3	8	7
211	R:R:I327	R:R:L251	4.28	No	No	0	9	9
212	R:R:F362	R:R:L251	4.87	Yes	No	0	9	9
213	R:R:F252	R:R:V256	5.24	Yes	No	0	7	6
214	R:R:F252	R:R:L323	7.31	Yes	No	0	7	8
215	R:R:F252	R:R:I327	3.77	Yes	No	0	7	9
216	R:R:I330	R:R:L255	4.28	No	No	0	8	8
217	R:R:E257	R:R:F260	7	No	No	0	5	6
218	R:R:E257	R:R:Y265	4.49	No	No	0	5	4
219	R:R:F259	R:R:F260	3.22	No	No	0	7	6
220	R:R:P261	R:R:R263	5.76	No	No	0	7	4
221	R:R:E262	R:R:Y265	11.22	No	No	0	6	4
222	R:R:Y265	R:R:Y269	2.98	No	Yes	0	4	7
223	R:R:F266	R:R:Y269	5.16	Yes	Yes	3	6	7
224	R:R:I271	R:R:W268	3.52	No	No	0	4	3
225	R:R:I271	R:R:T270	3.04	No	No	0	4	5
226	R:R:I272	R:R:T276	3.04	No	No	0	6	4
227	R:R:C280	R:R:P312	3.77	No	No	0	5	9
228	R:R:V283	R:R:V308	3.21	No	No	0	4	8
229	R:R:R288	R:R:W284	4	No	Yes	0	8	8
230	R:R:I309	R:R:W284	3.52	No	Yes	1	7	8
231	R:R:L287	R:R:L305	4.15	No	No	0	4	2
232	R:R:R288	R:R:W297	18.99	No	Yes	0	8	8
233	R:R:L305	R:R:R288	3.64	No	No	0	2	8
234	R:R:F291	R:R:Y290	3.09	No	No	0	3	3
235	R:R:D293	R:R:W297	12.28	No	Yes	9	6	8
236	R:R:N300	R:R:W306	18.08	No	Yes	0	6	5
237	R:R:I309	R:R:W306	5.87	No	Yes	0	7	5
238	R:R:K310	R:R:W306	11.6	No	Yes	0	6	5
239	R:R:K310	R:R:W307	8.12	No	No	0	6	6
240	R:R:K310	R:R:V314	6.07	No	No	0	6	4
241	R:R:G311	R:R:P312	4.06	No	No	0	4	9
242	R:R:M318	R:R:V314	3.04	No	No	0	4	4
243	R:R:I317	R:R:Y366	4.84	No	Yes	1	7	8
244	R:R:I317	R:R:T367	4.56	No	No	0	7	6
245	R:R:F362	R:R:N320	8.46	Yes	No	0	9	9
246	R:R:F321	R:R:I325	3.77	No	No	0	6	5
247	R:R:F321	R:R:T367	6.49	No	No	0	6	6
248	R:R:F324	R:R:T355	3.89	Yes	No	0	9	9
249	R:R:F324	R:R:L358	3.65	Yes	No	10	9	9
250	R:R:F324	R:R:F362	5.36	Yes	Yes	10	9	9
251	R:R:F324	R:R:I364	8.79	Yes	No	0	9	6
252	R:R:I328	R:R:L351	2.85	No	Yes	0	7	9
253	R:R:I328	R:R:T355	4.56	No	No	0	7	9
254	R:R:L331	R:R:S354	7.51	No	No	0	9	9
255	R:R:L351	R:R:V332	2.98	Yes	No	0	9	6
256	R:R:L335	R:R:R350	8.5	No	No	0	8	8
257	R:R:I347	R:R:S346	3.1	No	No	0	7	6
258	R:R:L357	R:R:R353	3.64	No	No	0	8	8
259	R:R:L357	R:R:Y400	3.52	No	Yes	0	8	9
260	R:R:F362	R:R:L358	7.31	Yes	No	10	9	9
261	R:R:I359	R:R:P360	3.39	No	No	0	8	9
262	R:R:I359	R:R:I364	2.94	No	No	0	8	6
263	R:R:P360	R:R:V395	3.53	No	No	0	9	6
264	R:R:L361	R:R:Y400	16.41	No	Yes	0	9	9
265	R:R:I364	R:R:T367	3.04	No	No	0	6	6
266	R:R:H365	R:R:Y366	16.33	No	Yes	1	9	8
267	R:R:H365	R:R:Q392	11.13	No	No	1	9	9
268	R:R:E385	R:R:Y366	4.49	No	Yes	0	8	8
269	R:R:Q392	R:R:Y366	4.51	No	Yes	1	9	8
270	R:R:F369	R:R:F371	4.29	Yes	No	0	6	4
271	R:R:F369	R:R:R381	11.76	Yes	No	0	6	7
272	R:R:F369	R:R:F384	4.29	Yes	No	12	6	3
273	R:R:E385	R:R:F369	7	No	Yes	0	8	6
274	R:R:N375	R:R:V376	4.43	No	No	0	5	4
275	R:R:E380	R:R:S377	7.19	No	No	0	5	5
276	R:R:F394	R:R:V398	5.24	No	No	0	5	5
277	R:R:L399	R:R:Y400	3.52	No	Yes	0	8	9
278	R:R:C401	R:R:F402	4.19	Yes	No	6	9	8
279	R:R:L403	R:R:N404	5.49	No	No	0	7	9
280	R:R:E410	R:R:K414	9.45	No	No	0	8	5
281	R:R:L168	R:R:M197	2.83	Yes	No	0	9	7
282	R:R:L175	R:R:M190	2.83	No	No	0	8	6
283	R:R:K154	R:R:L151	2.82	No	No	0	5	2
284	R:R:G273	R:R:W243	2.81	No	Yes	0	9	9
285	R:R:L249	R:R:L323	2.77	No	No	0	6	8
286	R:R:D298	R:R:M299	2.77	No	No	0	6	5
287	R:R:A200	R:R:Y161	2.67	No	Yes	0	8	7
288	R:R:F204	R:R:S162	2.64	No	No	0	7	7
289	R:R:E406	R:R:N186	2.63	No	No	0	9	9
290	R:R:F127	R:R:V114	2.62	No	Yes	0	3	6
291	R:R:F371	R:R:V376	2.62	No	No	0	4	4
292	R:R:F391	R:R:T163	2.59	No	No	0	7	5
293	R:R:E36	R:R:Q39	2.55	No	No	0	4	4
294	R:R:V383	R:R:Y149	2.52	No	Yes	0	5	4
295	R:R:T158	R:R:Y157	2.5	No	Yes	0	7	8
296	L:L:K20	R:R:F84	2.48	No	No	0	0	5
297	R:R:V231	R:R:W284	2.45	No	Yes	0	6	8
298	R:R:V231	R:R:W297	2.45	No	Yes	0	6	8
299	R:R:F291	R:R:L287	2.44	No	No	0	3	4
300	R:R:T303	R:R:W307	2.43	No	No	0	6	6
301	R:R:F47	R:R:N48	2.42	No	No	0	4	1
302	R:R:D132	R:R:F131	2.39	No	No	0	6	4
303	L:L:L23	L:L:Y22	2.34	No	No	0	0	0
304	R:R:L289	R:R:W297	2.28	No	Yes	0	3	8
305	R:R:F266	R:R:R263	2.14	Yes	No	0	6	4
306	R:R:F204	R:R:Y161	2.06	No	Yes	0	7	7
307	R:R:R264	R:R:W268	2	No	No	0	5	3
308	R:R:R416	R:R:W415	2	No	No	0	4	5
309	R:R:C54	R:R:P55	1.88	No	No	0	9	4
310	R:R:G160	R:R:V159	1.84	No	No	0	9	6
311	R:R:G275	R:R:T278	1.82	No	No	0	7	4
312	R:R:P52	R:R:S51	1.78	No	No	0	1	5
313	R:R:C118	R:R:V69	1.71	No	No	0	9	6
314	R:R:G363	R:R:L244	1.71	No	No	0	9	9
315	R:R:G387	R:R:L388	1.71	No	No	0	5	7
316	R:R:C401	R:R:V407	1.71	Yes	No	0	9	9
317	R:R:A67	R:R:V73	1.7	No	No	0	8	8
318	R:R:A133	R:R:V114	1.7	No	Yes	0	6	6
319	R:R:A285	R:R:V231	1.7	No	No	0	5	6
320	R:R:C226	R:R:T223	1.69	No	No	0	9	3
321	R:R:D121	R:R:G122	1.68	No	No	0	4	9
322	R:R:K65	R:R:P66	1.67	No	Yes	0	7	4
323	R:R:E120	R:R:G53	1.64	No	No	0	1	1
324	R:R:N85	R:R:P86	1.63	No	No	0	3	2
325	R:R:D132	R:R:P128	1.61	No	No	0	6	4
326	R:R:A370	R:R:M318	1.61	No	No	0	6	4
327	R:R:T278	R:R:V279	1.59	No	No	0	4	4
328	R:R:G389	R:R:H365	1.59	No	No	0	7	9
329	R:R:I174	R:R:V173	1.54	No	No	0	8	1
330	R:R:I174	R:R:V407	1.54	No	No	0	8	9
331	R:R:I330	R:R:V256	1.54	No	No	0	8	6
332	R:R:F252	R:R:G326	1.51	Yes	No	0	7	8
333	R:R:L156	R:R:V159	1.49	No	No	0	6	6
334	R:R:I201	R:R:I205	1.47	No	No	0	4	6
335	R:R:N191	R:R:T270	1.46	No	No	0	8	5
336	R:R:I174	R:R:K414	1.45	No	No	0	8	5
337	R:R:D301	R:R:T294	1.45	No	No	0	4	3
338	R:R:I330	R:R:K334	1.45	No	No	0	8	9
339	R:R:K28	R:R:K29	1.44	No	No	0	3	5
340	R:R:K29	R:R:M33	1.44	No	No	0	5	4
341	R:R:E125	R:R:S124	1.44	No	No	0	4	6
342	L:L:L23	R:R:I61	1.43	No	Yes	0	0	4
343	L:L:L27	R:R:I61	1.43	No	Yes	0	0	4
344	R:R:I61	R:R:L80	1.43	Yes	No	0	4	5
345	R:R:I201	R:R:L165	1.43	No	No	0	4	7
346	R:R:D301	R:R:M299	1.39	No	No	0	4	5
347	R:R:L331	R:R:L335	1.38	No	No	11	9	8
348	R:R:L331	R:R:L351	1.38	No	Yes	11	9	9
349	R:R:L335	R:R:L351	1.38	No	Yes	11	8	9
350	R:R:I347	R:R:Q336	1.37	No	No	0	7	7
351	R:R:E30	R:R:M33	1.35	No	No	0	7	4
352	R:R:L35	R:R:Q31	1.33	No	No	0	2	4
353	R:R:F371	R:R:S377	1.32	No	No	0	4	5
354	R:R:F369	R:R:V368	1.31	Yes	No	12	6	6
355	R:R:F384	R:R:V368	1.31	No	No	12	3	6
356	R:R:F27	R:R:I26	1.26	No	No	0	6	5
357	R:R:I83	R:R:R82	1.25	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	5.435	4	0	0
2	L:L:D3	5.0475	4	1	0
3	L:L:F6	4.778	5	1	0
4	L:L:Y10	8.4825	4	0	0
5	R:R:W58	10.37	4	4	7
6	R:R:I61	3.22	5	2	4
7	R:R:T62	7.946	5	2	5
8	R:R:W64	9.26714	7	2	9
9	R:R:P66	5.748	5	5	4
10	R:R:F81	4.4525	4	2	6
11	R:R:V114	6.415	4	2	6
12	R:R:W123	11.315	4	2	9
13	R:R:Y130	9.04429	7	2	8
14	R:R:Y149	6.7075	4	1	4
15	R:R:Y150	7.03	5	1	4
16	R:R:Y157	5.17286	7	1	8
17	R:R:Y161	5.53429	7	1	7
18	R:R:L168	3.93	4	0	9
19	R:R:F196	5.7425	4	0	8
20	R:R:R199	6.062	5	1	8
21	R:R:V203	4.8675	4	1	7
22	R:R:L210	4.682	5	8	7
23	R:R:Y211	8.294	5	0	4
24	R:R:F233	5.36667	6	1	6
25	R:R:H234	7.225	4	1	7
26	R:R:Y241	10.5875	4	1	7
27	R:R:F242	5.14	4	0	5
28	R:R:W243	8.435	4	7	9
29	R:R:Y250	7.3275	4	3	8
30	R:R:F252	4.4575	4	0	7
31	R:R:F266	6.37167	6	3	6
32	R:R:Y269	5.11	5	3	7
33	R:R:W274	6.5375	4	7	8
34	R:R:W284	5.1375	4	1	8
35	R:R:W297	11.378	5	9	8
36	R:R:W306	10.21	4	0	5
37	R:R:F324	5.4225	4	10	9
38	R:R:L351	2.1475	4	11	9
39	R:R:F362	5.92	6	10	9
40	R:R:Y366	8.52167	6	1	8
41	R:R:F369	5.73	5	12	6
42	R:R:L386	4.222	5	1	8
43	R:R:Y400	6.9525	4	0	9
44	R:R:C401	3.17	4	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:H234	19.2753	3.58	Yes	Yes	0	0	7
2	L:L:H1	R:R:V237	28.0767	9.69	Yes	No	0	0	6
3	L:L:H1	R:R:W306	21.4284	5.29	Yes	Yes	0	0	5
4	R:R:F233	R:R:H234	40.428	6.79	Yes	Yes	1	6	7
5	L:L:S2	R:R:L386	10.9177	3	No	Yes	0	0	8
6	R:R:F233	R:R:V237	24.0462	3.93	Yes	No	0	6	6
7	R:R:R199	R:R:V237	35.4234	5.23	Yes	No	0	8	6
8	R:R:R199	R:R:Y366	42.7176	3.09	Yes	Yes	1	8	8
9	R:R:E385	R:R:Y366	11.0726	4.49	No	Yes	0	8	8
10	L:L:S2	R:R:E385	10.5054	10.06	No	No	0	0	8
11	R:R:R199	R:R:Y161	80.1077	4.12	Yes	Yes	1	8	7
12	R:R:E385	R:R:F369	11.1776	7	No	Yes	0	8	6
13	R:R:Y157	R:R:Y161	74.6488	3.97	Yes	Yes	1	8	7
14	L:L:F6	L:L:Y10	11.8393	4.13	Yes	Yes	0	0	0
15	R:R:F233	R:R:K206	34.1631	8.69	Yes	No	0	6	6
16	L:L:T7	R:R:K206	17.3533	7.51	No	No	0	0	6
17	L:L:T7	R:R:Y211	16.836	3.75	No	Yes	0	0	4
18	L:L:Y10	R:R:Y211	10.0617	13.9	Yes	Yes	0	0	4
19	R:R:D207	R:R:K206	16.7573	8.3	No	No	0	7	6
20	R:R:D207	R:R:Y211	79.677	5.75	No	Yes	0	7	4
21	L:L:Y10	R:R:Y150	16.8544	9.93	Yes	Yes	0	0	4
22	R:R:L210	R:R:Y211	100	4.69	Yes	Yes	0	7	4
23	R:R:D298	R:R:L210	95.917	8.14	No	Yes	0	6	7
24	R:R:Q146	R:R:Y150	11.5925	4.51	No	Yes	1	1	4
25	R:R:D298	R:R:M299	94.2471	2.77	No	No	0	6	5
26	L:L:K15	R:R:M299	91.7028	2.88	No	No	0	0	5
27	L:L:K15	R:R:I83	90.8442	2.91	No	No	0	0	4
28	R:R:I83	R:R:R82	89.1112	1.25	No	No	0	4	4
29	R:R:F81	R:R:R82	88.2368	3.21	Yes	No	0	6	4
30	R:R:C77	R:R:F81	82.6835	4.19	No	Yes	2	9	6
31	R:R:C77	R:R:Y130	81.9693	4.03	No	Yes	2	9	8
32	R:R:I61	R:R:Y130	12.6375	7.25	Yes	Yes	2	4	8
33	R:R:W64	R:R:Y130	50.2009	9.65	Yes	Yes	2	9	8
34	R:R:W123	R:R:W64	37.4111	4.69	Yes	Yes	2	9	9
35	R:R:C54	R:R:W123	35.8619	18.28	No	Yes	0	9	9
36	R:R:C54	R:R:P55	28.804	1.88	No	No	0	9	4
37	R:R:N42	R:R:P55	27.6093	3.26	No	No	0	2	4
38	R:R:N42	R:R:P66	23.8939	11.4	No	Yes	5	2	4
39	R:R:K65	R:R:P66	17.8627	1.67	No	Yes	0	7	4
40	R:R:K37	R:R:K65	16.6207	4.31	No	No	0	4	7
41	R:R:C34	R:R:K37	11.6004	3.23	No	No	0	9	4
42	R:R:V114	R:R:Y130	17.2089	17.66	Yes	Yes	2	6	8
43	R:R:R116	R:R:W64	10.8389	25.99	No	Yes	2	9	9
44	R:R:P126	R:R:R116	10.3322	18.74	No	No	0	5	9
45	R:R:F127	R:R:V114	16.5524	2.62	No	Yes	0	3	6
46	R:R:F127	R:R:P128	12.8108	18.78	No	No	0	3	4
47	R:R:D132	R:R:P128	11.5531	1.61	No	No	0	6	4
48	R:R:N240	R:R:R199	46.5118	9.64	No	Yes	0	9	8
49	R:R:F196	R:R:N240	19.593	10.87	Yes	No	0	8	9
50	R:R:F196	R:R:L168	15.6335	3.65	Yes	Yes	0	8	9
51	R:R:R199	R:R:Y241	51.2091	8.23	Yes	Yes	1	8	7
52	R:R:I317	R:R:Y241	42.7439	3.63	No	Yes	1	7	7
53	R:R:I317	R:R:T367	84.0908	4.56	No	No	0	7	6
54	R:R:I364	R:R:T367	80.3335	3.04	No	No	0	6	6
55	R:R:F324	R:R:I364	75.2501	8.79	Yes	No	0	9	6
56	R:R:F324	R:R:F362	62.0612	5.36	Yes	Yes	10	9	9
57	R:R:E247	R:R:F362	42.9854	3.5	No	Yes	0	9	9
58	R:R:E247	R:R:H189	34.1919	7.39	No	No	0	9	9
59	R:R:H189	R:R:R185	27.0789	3.39	No	No	0	9	9
60	R:R:C183	R:R:R185	25.619	4.18	No	No	0	8	9
61	R:R:C183	R:R:N186	24.1539	4.72	No	No	0	8	9
62	R:R:L175	R:R:N186	21.2078	8.24	No	No	0	8	9
63	R:R:C401	R:R:L175	13.7508	3.17	Yes	No	0	9	8
64	R:R:I317	R:R:Y366	42.5863	4.84	No	Yes	1	7	8
65	R:R:N240	R:R:S195	30.3479	5.96	No	No	0	9	9
66	R:R:S195	R:R:S239	29.4893	3.26	No	No	0	9	8
67	R:R:P277	R:R:S239	18.4561	3.56	No	No	0	9	8
68	R:R:F242	R:R:P277	33.9005	5.78	Yes	No	0	5	9
69	R:R:F242	R:R:T276	24.3245	6.49	Yes	No	0	5	4
70	R:R:I272	R:R:T276	22.9355	3.04	No	No	0	6	4
71	R:R:I246	R:R:I272	21.5413	4.42	No	No	0	8	6
72	R:R:I246	R:R:Y269	20.1418	4.84	No	Yes	0	8	7
73	R:R:V313	R:R:Y241	23.3136	12.62	No	Yes	0	7	7
74	R:R:V238	R:R:V313	22.5994	4.81	No	No	0	6	7
75	R:R:P277	R:R:V238	21.9351	5.3	No	No	0	9	6
76	R:R:S239	R:R:W274	16.8649	7.41	No	Yes	0	8	8
77	R:R:H234	R:R:W284	32.22	10.58	Yes	Yes	1	7	8
78	R:R:R288	R:R:W284	18.4325	4	No	Yes	0	8	8
79	R:R:V231	R:R:W284	12.2962	2.45	No	Yes	0	6	8
80	R:R:F362	R:R:L251	16.836	4.87	Yes	No	0	9	9
81	R:R:I327	R:R:L251	15.3315	4.28	No	No	0	9	9
82	R:R:F252	R:R:I327	13.8217	3.77	Yes	No	0	7	9
83	R:R:K310	R:R:W306	16.9804	11.6	No	Yes	0	6	5
84	R:R:F324	R:R:T355	12.3067	3.89	Yes	No	0	9	9
85	R:R:I328	R:R:T355	10.7864	4.56	No	No	0	7	9
86	R:R:D207	R:R:Y157	63.7863	9.2	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:H234	3.58	0	Yes	Yes	0	7	0	1
L:L:H1	R:R:V237	9.69	0	Yes	No	0	6	0	1
L:L:H1	R:R:W306	5.29	0	Yes	Yes	0	5	0	1
L:L:S2	R:R:E385	10.06	0	No	No	0	8	0	1
L:L:S2	R:R:L386	3	0	No	Yes	0	8	0	1
L:L:D3	R:R:Y161	6.9	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:V203	2.92	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:F233	3.58	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:L386	6.79	1	Yes	Yes	0	8	0	1
L:L:I5	R:R:K378	4.36	0	No	No	0	5	0	1
L:L:I5	R:R:R381	5.01	0	No	No	0	7	0	1
L:L:F6	R:R:V153	5.24	1	Yes	No	0	6	0	1
L:L:F6	R:R:Y157	7.22	1	Yes	Yes	0	8	0	1
L:L:F6	R:R:L382	3.65	1	Yes	No	0	5	0	1
L:L:F6	R:R:L386	3.65	1	Yes	Yes	0	8	0	1
L:L:T7	R:R:K206	7.51	0	No	No	0	6	0	1
L:L:T7	R:R:Y211	3.75	0	No	Yes	0	4	0	1
L:L:D8	R:R:N300	6.73	0	No	No	0	6	0	1
L:L:S9	R:R:Y150	7.63	0	No	Yes	0	4	0	1
L:L:S9	R:R:K378	6.12	0	No	No	0	5	0	1
L:L:Y10	R:R:Y150	9.93	0	Yes	Yes	0	4	0	1
L:L:Y10	R:R:K154	5.97	0	Yes	No	0	5	0	1
L:L:Y10	R:R:Y211	13.9	0	Yes	Yes	0	4	0	1
L:L:S11	R:R:D298	11.78	0	No	No	0	6	0	1
L:L:Y13	R:R:Q146	9.02	0	No	No	0	1	0	1
L:L:Y13	R:R:D147	6.9	0	No	No	0	1	0	1
L:L:R14	R:R:Y211	13.38	0	No	Yes	0	4	0	1
L:L:K15	R:R:I83	2.91	0	No	No	0	4	0	1
L:L:K15	R:R:M299	2.88	0	No	No	0	5	0	1
L:L:Q16	R:R:I83	5.49	0	No	No	0	4	0	1
L:L:Y22	R:R:F27	12.38	0	No	No	0	6	0	1
L:L:V26	R:R:N60	2.96	0	No	No	0	6	0	1
R:R:I61	R:R:T62	4.56	2	Yes	Yes	4	5	1	2
R:R:I61	R:R:Y130	7.25	2	Yes	Yes	4	8	1	2
R:R:T62	R:R:Y130	17.48	2	Yes	Yes	5	8	2	2
R:R:F84	R:R:N85	15.71	0	No	No	5	3	1	2
R:R:F131	R:R:F84	11.79	0	No	No	4	5	2	1
R:R:Q146	R:R:Y150	4.51	1	No	Yes	1	4	1	1
R:R:Q146	R:R:R379	4.67	1	No	No	1	4	1	2
R:R:Y149	R:R:Y150	7.94	1	Yes	Yes	4	4	2	1
R:R:V153	R:R:Y149	5.05	1	No	Yes	6	4	1	2
R:R:R379	R:R:Y149	11.32	1	No	Yes	4	4	2	2
R:R:R379	R:R:Y150	5.14	1	No	Yes	4	4	2	1
R:R:L386	R:R:V153	2.98	1	Yes	No	8	6	1	1
R:R:K154	R:R:Y157	3.58	0	No	Yes	5	8	1	1
R:R:Y157	R:R:Y161	3.97	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y157	5.05	1	Yes	Yes	7	8	1	1
R:R:D207	R:R:Y157	9.2	0	No	Yes	7	8	2	1
R:R:L386	R:R:Y157	4.69	1	Yes	Yes	8	8	1	1
R:R:R199	R:R:Y161	4.12	1	Yes	Yes	8	7	2	1
R:R:V203	R:R:Y161	7.57	1	Yes	Yes	7	7	1	1
R:R:S390	R:R:Y161	11.45	0	No	Yes	9	7	2	1
R:R:R199	R:R:V237	5.23	1	Yes	No	8	6	2	1
R:R:R199	R:R:Y366	3.09	1	Yes	Yes	8	8	2	2
R:R:F233	R:R:S202	5.28	1	Yes	No	6	6	1	2
R:R:F233	R:R:V203	3.93	1	Yes	Yes	6	7	1	1
R:R:D207	R:R:K206	8.3	0	No	No	7	6	2	1
R:R:F233	R:R:K206	8.69	1	Yes	No	6	6	1	1
R:R:D207	R:R:Y211	5.75	0	No	Yes	7	4	2	1
R:R:L210	R:R:Y211	4.69	8	Yes	Yes	7	4	2	1
R:R:D298	R:R:L210	8.14	0	No	Yes	6	7	1	2
R:R:F233	R:R:H234	6.79	1	Yes	Yes	6	7	1	1
R:R:F233	R:R:V237	3.93	1	Yes	No	6	6	1	1
R:R:H234	R:R:W284	10.58	1	Yes	Yes	7	8	1	2
R:R:H234	R:R:I309	7.95	1	Yes	No	7	7	1	2
R:R:I309	R:R:W284	3.52	1	No	Yes	7	8	2	2
R:R:N300	R:R:W306	18.08	0	No	Yes	6	5	1	1
R:R:I309	R:R:W306	5.87	1	No	Yes	7	5	2	1
R:R:K310	R:R:W306	11.6	0	No	Yes	6	5	2	1
R:R:E385	R:R:Y366	4.49	0	No	Yes	8	8	1	2
R:R:F369	R:R:R381	11.76	12	Yes	No	6	7	2	1
R:R:E385	R:R:F369	7	0	No	Yes	8	6	1	2
R:R:K154	R:R:L151	2.82	0	No	No	5	2	1	2
R:R:D298	R:R:M299	2.77	0	No	No	6	5	1	1
R:R:A200	R:R:Y161	2.67	0	No	Yes	8	7	2	1
R:R:T158	R:R:Y157	2.5	0	No	Yes	7	8	2	1
L:L:K20	R:R:F84	2.48	0	No	No	0	5	0	1
R:R:F204	R:R:Y161	2.06	0	No	Yes	7	7	2	1
L:L:L23	R:R:I61	1.43	0	No	Yes	0	4	0	1
L:L:L27	R:R:I61	1.43	0	No	Yes	0	4	0	1
R:R:I61	R:R:L80	1.43	2	Yes	No	4	5	1	2
R:R:D301	R:R:M299	1.39	0	No	No	4	5	2	1
R:R:F27	R:R:I26	1.26	0	No	No	6	5	1	2
R:R:I83	R:R:R82	1.25	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6LPB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	316
Number of Links	357
Number of Hubs	44
Number of Links mediated by Hubs	171
Number of Communities	12
Number of Nodes involved in Communities	67
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	87734
Length Of Smallest Path	3
Average Path Length	17.3738
Length of Longest Path	45
Minimum Path Strength	1.395
Average Path Strength	5.69237
Maximum Path Strength	22.365
Minimum Path Correlation	0.7
Average Path Correlation	0.966873
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	65.8718
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.7057
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • small GTPase binding • molecular transducer activity • signaling receptor activity • adenylate cyclase binding • vasoactive intestinal polypeptide receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • response to xenobiotic stimulus • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • multicellular organismal response to stress • response to ethanol • cell surface receptor signaling pathway • intracellular signal transduction • cAMP/PKA signal transduction • intracellular signaling cassette • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • regulation of calcium ion transport into cytosol • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of monoatomic ion transport • transmembrane transport • positive regulation of calcium ion transport into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • calcium ion transport into cytosol • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • positive regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of small GTPase mediated signal transduction • development of primary sexual characteristics • sex differentiation • female sex differentiation • development of primary female sexual characteristics • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • response to estradiol • negative regulation of response to reactive oxygen species • response to reactive oxygen species • response to oxidative stress • regulation of response to reactive oxygen species • regulation of response to oxidative stress • negative regulation of response to oxidative stress • cell surface • membrane microdomain • membrane raft • plasma membrane raft • caveola • receptor complex • endosome • intracellular vesicle • cytoplasmic vesicle • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • regulation of chemokine (C-C motif) ligand 5 production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • multi-multicellular organism process • female pregnancy • multi-organism reproductive process • positive regulation of hydrolase activity • regulation of hydrolase activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cellular process • negative regulation of cell cycle • cell cycle • regulation of cell cycle • regulation of G protein-coupled receptor signaling pathway • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of protein modification process • protein metabolic process • positive regulation of protein kinase activity • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • phosphorylation • regulation of protein metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of growth hormone secretion • positive regulation of peptide hormone secretion • positive regulation of growth hormone secretion • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • neuron differentiation • neuron development • cellular component organization or biogenesis • perikaryon • neuronal cell body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41586
Sequence	>6LPB_nogp_Chain_R I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V M G V V S R N C T E D G W S E P F P H Y F D A C Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C C T R N F I H M N L F V S F M L R A I S V F I K D W I L Y T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E T F F P E R R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D D T G C W D M N D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L Q S S I Y L R L A R S T L L L I P L F G I H Y T V F A F N V S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E V Q A E I K R K W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6P9Y	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9Y (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	8E3X	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3X (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	6LPB	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ1	3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6LPB (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8

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