psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K28	R:R:Q31	5.42	No	Yes	0	3	4
2	R:R:K28	R:R:N60	8.39	No	No	0	3	6
3	R:R:C34	R:R:Q31	6.1	No	Yes	7	9	4
4	R:R:L35	R:R:Q31	13.31	No	Yes	0	2	4
5	R:R:Q31	R:R:W58	14.24	Yes	Yes	7	4	7
6	R:R:K37	R:R:M33	4.32	No	No	0	4	4
7	R:R:C34	R:R:W58	6.53	No	Yes	7	9	7
8	R:R:C34	R:R:C63	7.28	No	No	7	9	9
9	R:R:A67	R:R:C54	3.61	No	Yes	1	8	9
10	R:R:C118	R:R:C54	7.28	Yes	Yes	1	9	9
11	R:R:C54	R:R:W123	13.06	Yes	Yes	1	9	9
12	R:R:G56	R:R:P66	4.06	No	No	0	5	4
13	R:R:D59	R:R:M57	5.54	No	No	1	9	6
14	R:R:M57	R:R:W64	5.82	No	Yes	1	6	9
15	R:R:M57	R:R:W123	4.65	No	Yes	1	6	9
16	R:R:N60	R:R:W58	7.91	No	Yes	0	6	7
17	R:R:C63	R:R:W58	5.22	No	Yes	7	9	7
18	R:R:D59	R:R:I61	4.2	No	No	0	9	4
19	R:R:D59	R:R:W64	7.82	No	Yes	1	9	9
20	L:L:R8	R:R:N60	4.82	No	No	0	0	6
21	R:R:I61	R:R:Y130	8.46	No	Yes	0	4	8
22	R:R:T62	R:R:W64	9.7	No	Yes	0	5	9
23	R:R:V73	R:R:W64	4.9	Yes	Yes	1	8	9
24	R:R:V75	R:R:W64	4.9	No	Yes	0	6	9
25	R:R:R116	R:R:W64	13	No	Yes	1	9	9
26	R:R:W123	R:R:W64	28.12	Yes	Yes	1	9	9
27	R:R:A67	R:R:E71	6.03	No	No	0	8	3
28	R:R:A67	R:R:C118	3.61	No	Yes	1	8	9
29	R:R:E71	R:R:H68	3.69	No	No	0	3	2
30	R:R:E120	R:R:V69	4.28	No	No	0	1	6
31	R:R:E71	R:R:V73	5.7	No	Yes	0	3	8
32	R:R:M72	R:R:S115	6.13	No	No	0	4	5
33	R:R:M72	R:R:N117	14.02	No	No	0	4	4
34	R:R:V73	R:R:W123	4.9	Yes	Yes	1	8	9
35	R:R:L74	R:R:V113	4.47	No	No	0	4	1
36	R:R:L74	R:R:S115	7.51	No	No	0	4	5
37	R:R:M111	R:R:S76	6.13	No	No	0	3	4
38	R:R:S76	R:R:V113	3.23	No	No	0	4	1
39	R:R:C134	R:R:C77	7.28	No	No	0	9	9
40	R:R:L80	R:R:P78	4.93	No	No	0	5	9
41	R:R:E79	R:R:R82	15.12	No	No	0	2	4
42	R:R:F81	R:R:L80	12.18	No	No	0	6	5
43	R:R:C134	R:R:F81	9.78	No	No	0	9	6
44	R:R:F136	R:R:F84	5.36	Yes	No	0	3	5
45	L:L:N45	R:R:F84	6.04	No	No	0	0	5
46	L:L:F48	R:R:F84	6.43	No	No	0	0	5
47	R:R:N85	R:R:P86	4.89	No	No	0	3	2
48	R:R:D110	R:R:N85	14.81	No	No	0	4	3
49	R:R:R116	R:R:W123	8	No	Yes	1	9	9
50	R:R:P126	R:R:R116	15.85	Yes	No	1	5	9
51	R:R:C118	R:R:W123	11.75	Yes	Yes	1	9	9
52	R:R:E120	R:R:T119	5.64	No	No	0	1	6
53	R:R:D121	R:R:T119	10.12	No	No	0	4	6
54	R:R:E125	R:R:F127	5.83	No	No	0	4	3
55	R:R:P126	R:R:Y130	8.34	Yes	Yes	1	5	8
56	L:L:T4	R:R:P126	3.5	No	Yes	1	0	5
57	R:R:F131	R:R:H129	13.58	Yes	No	1	4	2
58	R:R:D132	R:R:H129	3.78	No	No	1	6	2
59	L:L:T4	R:R:Y130	4.99	No	Yes	1	0	8
60	L:L:F7	R:R:Y130	7.22	No	Yes	1	0	8
61	R:R:D132	R:R:F131	7.17	No	Yes	1	6	4
62	L:L:F7	R:R:F131	7.5	No	Yes	1	0	4
63	L:L:F59	R:R:F131	7.5	No	Yes	1	0	4
64	L:L:K60	R:R:F131	4.96	No	Yes	0	0	4
65	R:R:F136	R:R:G135	4.52	Yes	No	0	3	3
66	L:L:K49	R:R:F136	13.65	No	Yes	0	0	3
67	L:L:M52	R:R:F136	4.98	Yes	Yes	0	0	3
68	L:L:K53	R:R:F136	8.69	No	Yes	0	0	3
69	R:R:D145	R:R:D147	13.31	No	Yes	0	1	1
70	R:R:Q146	R:R:Y150	3.38	No	Yes	0	1	4
71	L:L:S21	R:R:D147	5.89	No	Yes	0	0	1
72	R:R:Y149	R:R:Y150	6.95	No	Yes	0	4	4
73	R:R:V153	R:R:Y149	3.79	No	No	0	6	4
74	R:R:E380	R:R:Y149	3.37	No	No	0	5	4
75	R:R:R379	R:R:Y150	7.2	No	Yes	2	4	4
76	L:L:L24	R:R:Y150	8.21	No	Yes	0	0	4
77	L:L:Q25	R:R:Y150	16.91	Yes	Yes	2	0	4
78	L:L:V28	R:R:Y150	5.05	No	Yes	0	0	4
79	R:R:S152	R:R:V153	3.23	No	No	0	4	6
80	R:R:K154	R:R:Y157	8.36	No	Yes	0	5	8
81	R:R:K154	R:R:W208	5.8	No	No	0	5	4
82	R:R:T158	R:R:Y157	4.99	No	Yes	0	7	8
83	R:R:L386	R:R:Y157	4.69	No	Yes	0	8	8
84	L:L:T31	R:R:Y157	7.49	No	Yes	0	0	8
85	R:R:F204	R:R:T158	3.89	No	No	0	7	7
86	R:R:G160	R:R:S390	3.71	No	Yes	9	9	9
87	R:R:F391	R:R:G160	7.53	No	No	9	7	9
88	R:R:R199	R:R:Y161	5.14	Yes	Yes	0	8	7
89	R:R:A200	R:R:Y161	5.34	No	Yes	0	8	7
90	R:R:V203	R:R:Y161	3.79	No	Yes	0	7	7
91	R:R:F204	R:R:S162	3.96	No	No	0	7	7
92	R:R:F394	R:R:L163	8.53	No	No	0	5	5
93	R:R:G393	R:R:S164	3.71	No	No	0	9	9
94	R:R:L165	R:R:M197	5.65	No	No	0	7	7
95	R:R:F193	R:R:L168	4.87	No	No	0	8	9
96	R:R:L168	R:R:M197	4.24	No	No	0	9	7
97	R:R:A171	R:R:C401	3.61	No	No	0	9	9
98	R:R:L175	R:R:N186	8.24	Yes	No	0	8	9
99	R:R:L175	R:R:M190	9.9	Yes	No	0	8	6
100	R:R:F178	R:R:I411	3.77	No	No	0	6	5
101	R:R:H182	R:R:R179	6.77	No	No	0	8	8
102	R:R:E406	R:R:K180	4.05	No	No	0	9	7
103	R:R:E410	R:R:K180	8.1	No	No	0	8	7
104	R:R:E406	R:R:L181	5.3	No	No	0	9	9
105	R:R:L181	R:R:V407	5.96	No	No	0	9	9
106	R:R:F187	R:R:H182	7.92	No	No	0	6	8
107	R:R:N186	R:R:R185	4.82	No	No	0	9	9
108	R:R:F187	R:R:M190	4.98	No	No	0	6	6
109	R:R:I188	R:R:W243	3.52	Yes	Yes	0	9	9
110	R:R:E247	R:R:I188	4.1	Yes	Yes	0	9	9
111	R:R:I188	R:R:Y250	3.63	Yes	No	0	9	8
112	R:R:F266	R:R:I188	5.02	No	Yes	0	6	9
113	R:R:E247	R:R:H189	9.85	Yes	No	0	9	9
114	R:R:H189	R:R:Y400	8.71	No	No	0	9	9
115	R:R:N191	R:R:W243	20.34	No	Yes	3	8	9
116	R:R:N191	R:R:T270	4.39	No	No	3	8	5
117	R:R:N191	R:R:W274	12.43	No	Yes	3	8	8
118	R:R:E247	R:R:L192	6.63	Yes	No	0	9	9
119	R:R:F193	R:R:V396	3.93	No	No	0	8	9
120	R:R:N240	R:R:S195	8.94	No	No	0	9	9
121	R:R:F196	R:R:N240	10.87	Yes	No	0	8	9
122	R:R:F196	R:R:Q392	9.37	Yes	No	0	8	9
123	R:R:F196	R:R:G393	6.02	Yes	No	0	8	9
124	R:R:C236	R:R:L198	7.94	No	No	0	5	7
125	R:R:R199	R:R:V237	10.46	Yes	No	0	8	6
126	R:R:N240	R:R:R199	9.64	No	Yes	0	9	8
127	R:R:R199	R:R:Y241	10.29	Yes	Yes	5	8	7
128	R:R:R199	R:R:Y366	6.17	Yes	Yes	5	8	8
129	R:R:F233	R:R:S202	6.61	No	No	0	6	6
130	R:R:C236	R:R:S202	3.44	No	No	0	5	6
131	R:R:D207	R:R:V203	5.84	No	No	0	7	7
132	L:L:T31	R:R:V203	4.76	No	No	0	0	7
133	R:R:K206	R:R:V229	6.07	No	No	0	6	6
134	R:R:F232	R:R:K206	9.93	No	No	0	4	6
135	R:R:D207	R:R:L210	6.79	No	Yes	0	7	7
136	R:R:L210	R:R:Y211	19.93	Yes	Yes	0	7	4
137	R:R:C226	R:R:L210	4.76	No	Yes	0	9	7
138	R:R:L210	R:R:V229	8.94	Yes	No	0	7	6
139	R:R:Q214	R:R:Y211	3.38	No	Yes	0	2	4
140	R:R:D298	R:R:Y211	5.75	No	Yes	0	6	4
141	L:L:T26	R:R:Y211	6.24	No	Yes	0	0	4
142	L:L:S27	R:R:Y211	3.82	No	Yes	0	0	4
143	L:L:T30	R:R:Y211	4.99	No	Yes	0	0	4
144	R:R:F220	R:R:Q214	8.2	No	No	0	3	2
145	R:R:I221	R:R:Q214	5.49	Yes	No	0	3	2
146	R:R:I221	R:R:N217	9.91	Yes	No	0	3	2
147	R:R:C219	R:R:H218	5.9	No	No	0	4	3
148	L:L:H19	R:R:F220	4.53	No	No	0	0	3
149	R:R:G295	R:R:S222	3.71	No	No	0	4	6
150	R:R:E225	R:R:T223	15.52	No	No	0	5	3
151	R:R:C226	R:R:C296	7.28	No	No	0	9	9
152	R:R:K227	R:R:V231	7.59	No	No	0	7	6
153	R:R:K227	R:R:R288	3.71	No	Yes	4	7	8
154	R:R:K227	R:R:W297	27.85	No	Yes	4	7	8
155	R:R:H234	R:R:M230	3.94	Yes	No	0	7	6
156	R:R:C236	R:R:F232	6.98	No	No	0	5	4
157	R:R:F233	R:R:H234	7.92	No	Yes	0	6	7
158	R:R:F233	R:R:V237	3.93	No	No	0	6	6
159	R:R:H234	R:R:W284	5.29	Yes	No	0	7	8
160	R:R:H234	R:R:W306	5.29	Yes	Yes	0	7	5
161	R:R:W274	R:R:Y235	5.79	Yes	No	0	8	9
162	R:R:L278	R:R:Y235	8.21	No	No	0	4	9
163	R:R:V281	R:R:Y235	6.31	No	No	0	7	9
164	R:R:P277	R:R:S239	3.56	Yes	No	0	9	8
165	R:R:V313	R:R:Y241	11.36	No	Yes	0	7	7
166	R:R:I317	R:R:Y241	3.63	No	Yes	0	7	7
167	R:R:Y241	R:R:Y366	14.89	Yes	Yes	5	7	8
168	L:L:T33	R:R:Y241	9.99	No	Yes	5	0	7
169	L:L:F34	R:R:Y241	5.16	No	Yes	5	0	7
170	R:R:F242	R:R:F245	4.29	No	Yes	0	5	8
171	R:R:F242	R:R:P277	7.22	No	Yes	0	5	9
172	R:R:I246	R:R:W243	12.92	No	Yes	3	8	9
173	R:R:T270	R:R:W243	4.85	No	Yes	3	5	9
174	R:R:G273	R:R:W243	5.63	No	Yes	0	9	9
175	R:R:W243	R:R:W274	14.06	Yes	Yes	3	9	8
176	R:R:F245	R:R:S316	5.28	Yes	No	0	8	7
177	R:R:F245	R:R:N320	4.83	Yes	No	0	8	9
178	R:R:I246	R:R:Y269	4.84	No	Yes	3	8	7
179	R:R:I246	R:R:I272	4.42	No	No	3	8	6
180	R:R:E247	R:R:L361	11.93	Yes	No	0	9	9
181	R:R:F362	R:R:G248	6.02	Yes	No	0	9	9
182	R:R:L249	R:R:Y269	7.03	No	Yes	0	6	7
183	R:R:L254	R:R:Y250	3.52	No	No	0	7	8
184	R:R:F252	R:R:L323	7.31	No	No	0	7	8
185	R:R:T253	R:R:Y269	3.75	No	Yes	0	7	7
186	R:R:E257	R:R:F260	4.66	No	No	0	5	6
187	R:R:F259	R:R:P261	5.78	No	No	0	7	7
188	R:R:E262	R:R:F260	5.83	No	No	0	6	6
189	R:R:F260	R:R:Y265	4.13	No	No	0	6	4
190	R:R:P261	R:R:R264	5.76	No	No	0	7	5
191	R:R:P261	R:R:Y265	11.13	No	No	0	7	4
192	R:R:F266	R:R:R263	5.34	No	No	0	6	4
193	R:R:R263	R:R:Y267	11.32	No	No	0	4	3
194	R:R:I271	R:R:W268	3.52	No	No	0	4	3
195	R:R:I272	R:R:Y269	3.63	No	Yes	3	6	7
196	R:R:G273	R:R:P277	4.06	No	Yes	0	9	9
197	R:R:F280	R:R:P312	8.67	No	No	0	5	9
198	R:R:R288	R:R:W284	15.99	Yes	No	0	8	8
199	R:R:I309	R:R:W284	7.05	No	No	0	7	8
200	R:R:L287	R:R:L305	4.15	No	Yes	4	4	2
201	R:R:R288	R:R:W297	11	Yes	Yes	4	8	8
202	R:R:L305	R:R:R288	6.07	Yes	Yes	4	2	8
203	R:R:L289	R:R:W297	3.42	No	Yes	0	3	8
204	R:R:D292	R:R:T294	5.78	No	No	0	5	3
205	R:R:D293	R:R:W297	15.63	No	Yes	0	6	8
206	R:R:G295	R:R:T294	3.64	No	No	0	4	3
207	R:R:D298	R:R:M299	4.16	No	Yes	0	6	5
208	R:R:D301	R:R:M299	4.16	No	Yes	2	4	5
209	L:L:M37	R:R:M299	4.33	Yes	Yes	2	0	5
210	L:L:T39	R:R:M299	6.02	No	Yes	2	0	5
211	R:R:N300	R:R:W306	11.3	No	Yes	10	6	5
212	L:L:S36	R:R:N300	5.96	No	No	10	0	6
213	L:L:T39	R:R:D301	8.67	No	No	2	0	4
214	R:R:L305	R:R:S302	10.51	Yes	No	0	2	5
215	R:R:I309	R:R:W306	3.52	No	Yes	0	7	5
216	R:R:K310	R:R:W306	10.44	No	Yes	0	6	5
217	L:L:S36	R:R:W306	13.59	No	Yes	10	0	5
218	R:R:K310	R:R:W307	18.57	No	No	0	6	6
219	R:R:G311	R:R:P312	4.06	No	No	0	4	9
220	R:R:G315	R:R:M318	6.99	No	No	0	4	4
221	R:R:I317	R:R:S316	4.64	No	No	0	7	7
222	R:R:F362	R:R:N320	6.04	Yes	No	0	9	9
223	R:R:F321	R:R:I325	5.02	No	No	0	6	5
224	R:R:F321	R:R:I364	3.77	No	Yes	0	6	6
225	R:R:F324	R:R:I328	6.28	Yes	No	0	9	7
226	R:R:F324	R:R:L358	7.31	Yes	No	6	9	9
227	R:R:F324	R:R:I359	3.77	Yes	No	6	9	8
228	R:R:F324	R:R:F362	4.29	Yes	Yes	6	9	9
229	R:R:F324	R:R:I364	6.28	Yes	Yes	6	9	6
230	R:R:P338	R:R:S337	5.34	No	No	0	6	7
231	R:R:I347	R:R:Y348	8.46	No	No	0	7	7
232	R:R:R350	R:R:R353	8.53	No	No	0	8	8
233	R:R:L357	R:R:L399	5.54	No	No	0	8	8
234	R:R:F362	R:R:L358	4.87	Yes	No	6	9	9
235	R:R:I359	R:R:P360	3.39	No	No	0	8	9
236	R:R:I359	R:R:I364	5.89	No	Yes	6	8	6
237	R:R:P360	R:R:V395	5.3	No	No	0	9	6
238	R:R:L399	R:R:P360	3.28	No	No	0	8	9
239	R:R:F362	R:R:L361	7.31	Yes	No	0	9	9
240	R:R:L361	R:R:Y400	24.62	No	No	0	9	9
241	R:R:H365	R:R:Y366	14.16	No	Yes	0	9	8
242	R:R:H365	R:R:L388	5.14	No	No	0	9	7
243	R:R:H365	R:R:Q392	4.95	No	No	0	9	9
244	R:R:G389	R:R:Y366	4.35	No	Yes	0	7	8
245	R:R:F369	R:R:V368	5.24	No	No	0	6	6
246	R:R:E385	R:R:F369	20.99	No	No	0	8	6
247	R:R:E374	R:R:R381	5.82	No	No	0	4	7
248	R:R:E380	R:R:K378	5.4	No	No	0	5	5
249	R:R:K378	R:R:R381	4.95	No	No	0	5	7
250	L:L:Q25	R:R:R379	8.18	Yes	No	2	0	4
251	L:L:T35	R:R:R381	5.17	Yes	No	0	0	7
252	L:L:Q29	R:R:L382	6.65	Yes	No	2	0	5
253	L:L:T35	R:R:L382	4.42	Yes	No	2	0	5
254	R:R:E385	R:R:L386	3.98	No	No	0	8	8
255	R:R:G387	R:R:S390	3.71	No	Yes	0	5	9
256	R:R:F391	R:R:S390	7.93	No	Yes	9	7	9
257	R:R:F394	R:R:V398	3.93	No	No	0	5	5
258	R:R:L399	R:R:Y400	4.69	No	No	0	8	9
259	R:R:N404	R:R:V407	8.87	No	No	0	9	9
260	R:R:E410	R:R:R413	11.63	No	No	0	8	7
261	R:R:K412	R:R:W415	4.64	No	No	0	6	5
262	R:R:R416	R:R:W415	5	No	No	0	4	5
263	L:L:C1	L:L:T4	3.38	No	No	0	0	0
264	L:L:C1	L:L:C5	7.28	No	No	0	0	0
265	L:L:F59	L:L:F7	6.43	No	No	1	0	0
266	L:L:I11	L:L:R8	6.26	No	No	0	0	0
267	L:L:D12	L:L:D13	11.98	No	No	11	0	0
268	L:L:C14	L:L:C51	7.28	No	No	8	0	0
269	L:L:C14	L:L:M52	3.24	No	Yes	8	0	0
270	L:L:F48	L:L:Q15	3.51	No	No	0	0	0
271	L:L:H19	L:L:N22	7.65	No	No	0	0	0
272	L:L:H19	L:L:V23	6.92	No	No	0	0	0
273	L:L:L42	L:L:N22	4.12	No	No	2	0	0
274	L:L:N22	L:L:P43	3.26	No	Yes	2	0	0
275	L:L:Q25	L:L:Q29	6.4	Yes	Yes	2	0	0
276	L:L:M37	L:L:Q25	5.44	Yes	Yes	2	0	0
277	L:L:P43	L:L:Q25	7.9	Yes	Yes	2	0	0
278	L:L:Q29	L:L:T35	7.09	Yes	Yes	2	0	0
279	L:L:M37	L:L:Q29	8.16	Yes	Yes	2	0	0
280	L:L:F34	L:L:T33	15.56	No	No	5	0	0
281	L:L:D38	L:L:S40	5.89	No	No	0	0	0
282	L:L:D38	L:L:Q41	7.83	No	No	0	0	0
283	L:L:L42	L:L:P43	4.93	No	Yes	2	0	0
284	L:L:G44	L:L:V47	3.68	No	No	0	0	0
285	L:L:E50	L:L:V47	9.98	No	No	0	0	0
286	L:L:F48	L:L:M52	3.73	No	Yes	0	0	0
287	L:L:C51	L:L:M52	4.86	No	Yes	8	0	0
288	L:L:E58	L:L:K55	9.45	No	No	0	0	0
289	R:R:F136	R:R:F81	3.22	Yes	No	0	3	6
290	R:R:D132	R:R:P128	3.22	No	No	0	6	4
291	L:L:A10	L:L:M52	3.22	No	Yes	0	0	0
292	R:R:S354	R:R:T355	3.2	No	No	0	9	9
293	R:R:T253	R:R:V256	3.17	No	No	0	7	6
294	R:R:E125	R:R:P126	3.14	No	Yes	0	4	5
295	R:R:I309	R:R:V238	3.07	No	No	0	7	6
296	L:L:C14	L:L:Q17	3.05	No	No	0	0	0
297	R:R:K65	R:R:V73	3.04	No	Yes	0	7	8
298	R:R:I221	R:R:T223	3.04	Yes	No	0	3	3
299	R:R:M318	R:R:V314	3.04	No	No	0	4	4
300	R:R:I364	R:R:T367	3.04	Yes	No	0	6	6
301	R:R:R264	R:R:W268	3	No	No	0	5	3
302	R:R:L331	R:R:S354	3	No	No	0	9	9
303	R:R:L351	R:R:S354	3	No	No	0	9	9
304	L:L:A3	R:R:H129	2.93	No	No	0	0	2
305	R:R:M172	R:R:M190	2.89	No	No	0	6	6
306	R:R:F242	R:R:P312	2.89	No	No	0	5	9
307	L:L:K55	L:L:M52	2.88	No	Yes	0	0	0
308	R:R:I174	R:R:L175	2.85	No	Yes	0	8	8
309	R:R:E257	R:R:V256	2.85	No	No	0	5	6
310	R:R:I327	R:R:L358	2.85	No	No	0	9	9
311	R:R:C183	R:R:R185	2.79	No	No	0	8	9
312	R:R:A167	R:R:F394	2.77	No	No	0	7	5
313	R:R:A171	R:R:F402	2.77	No	No	0	9	8
314	R:R:L192	R:R:L244	2.77	No	No	0	9	9
315	R:R:L249	R:R:L323	2.77	No	No	0	6	8
316	R:R:L335	R:R:L351	2.77	No	No	0	8	9
317	L:L:F34	R:R:A370	2.77	No	No	0	0	6
318	L:L:D12	L:L:K9	2.77	No	Yes	11	0	0
319	L:L:D13	L:L:K9	2.77	No	Yes	11	0	0
320	L:L:I11	L:L:Q15	2.74	No	No	0	0	0
321	R:R:E213	R:R:I221	2.73	No	Yes	0	3	3
322	L:L:L24	R:R:D147	2.71	No	Yes	0	0	1
323	R:R:K412	R:R:Q408	2.71	No	No	0	6	7
324	L:L:K55	L:L:Q54	2.71	No	No	0	0	0
325	L:L:K57	L:L:Q54	2.71	No	No	0	0	0
326	R:R:E30	R:R:K29	2.7	No	No	0	7	5
327	R:R:F196	R:R:V396	2.62	Yes	No	0	8	9
328	R:R:F245	R:R:V319	2.62	Yes	No	0	8	6
329	R:R:F280	R:R:V279	2.62	No	No	0	5	4
330	R:R:F266	R:R:T184	2.59	No	No	0	6	7
331	R:R:S390	R:R:Y161	2.54	Yes	Yes	0	9	7
332	R:R:V114	R:R:Y130	2.52	No	Yes	0	6	8
333	L:L:H20	R:R:D147	2.52	No	Yes	0	0	1
334	R:R:F204	R:R:I205	2.51	No	No	0	7	6
335	R:R:T286	R:R:Y290	2.5	No	No	0	4	3
336	R:R:F371	R:R:M318	2.49	No	No	0	4	4
337	R:R:M111	R:R:R82	2.48	No	No	0	3	4
338	L:L:K56	R:R:F131	2.48	No	Yes	0	0	4
339	L:L:K9	L:L:R8	2.48	Yes	No	0	0	0
340	R:R:V194	R:R:W274	2.45	No	Yes	0	4	8
341	R:R:F193	R:R:L175	2.44	No	Yes	0	8	8
342	R:R:F178	R:R:L181	2.44	No	No	0	6	9
343	R:R:F384	R:R:L388	2.44	No	No	0	3	7
344	R:R:N404	R:R:R185	2.41	No	No	0	9	9
345	R:R:D292	R:R:F291	2.39	No	No	0	5	3
346	R:R:F178	R:R:R177	2.14	No	No	0	6	3
347	R:R:G56	R:R:P55	2.03	No	No	0	5	4
348	R:R:G275	R:R:P277	2.03	No	Yes	0	7	9
349	L:L:G44	L:L:P43	2.03	No	Yes	0	0	0
350	R:R:C118	R:R:G53	1.96	Yes	No	0	9	1
351	R:R:C54	R:R:G122	1.96	Yes	No	0	9	9
352	R:R:A133	R:R:G112	1.95	No	No	0	6	6
353	L:L:A18	L:L:G44	1.95	No	No	0	0	0
354	R:R:C54	R:R:P55	1.88	Yes	No	0	9	4
355	R:R:A276	R:R:P277	1.87	No	Yes	0	4	9
356	R:R:G53	R:R:V69	1.84	No	No	0	1	6
357	R:R:G70	R:R:V69	1.84	No	No	0	7	6
358	R:R:G160	R:R:V159	1.84	No	No	0	9	6
359	R:R:G326	R:R:V329	1.84	No	No	0	8	8
360	R:R:A133	R:R:C77	1.81	No	No	0	6	9
361	R:R:A171	R:R:A397	1.79	No	No	0	9	9
362	R:R:P128	R:R:S115	1.78	No	No	0	4	5
363	R:R:P373	R:R:S372	1.78	No	No	0	8	5
364	R:R:G387	R:R:L156	1.71	No	No	0	5	6
365	R:R:A133	R:R:V114	1.7	No	No	0	6	6
366	R:R:A285	R:R:V231	1.7	No	No	0	5	6
367	R:R:G405	R:R:N404	1.7	No	No	0	5	9
368	R:R:A304	R:R:T303	1.68	No	No	0	1	6
369	L:L:A32	L:L:T35	1.68	No	Yes	0	0	0
370	R:R:C401	R:R:I174	1.64	No	No	0	9	8
371	R:R:G363	R:R:Q392	1.64	No	No	0	9	9
372	R:R:V283	R:R:V308	1.6	No	No	4	4	8
373	R:R:T223	R:R:V224	1.59	No	No	0	3	4
374	R:R:A352	R:R:L349	1.58	No	No	0	8	6
375	R:R:C219	R:R:N217	1.57	No	No	0	4	2
376	R:R:I209	R:R:V229	1.54	No	No	0	5	6
377	R:R:K378	R:R:S377	1.53	No	No	0	5	5
378	R:R:K414	R:R:S417	1.53	No	No	0	5	7
379	R:R:A32	R:R:Q31	1.52	No	Yes	0	2	4
380	R:R:I328	R:R:T355	1.52	No	No	0	7	9
381	R:R:A212	R:R:E213	1.51	No	No	0	4	3
382	R:R:F252	R:R:G326	1.51	No	No	0	7	8
383	R:R:L163	R:R:S162	1.5	No	No	0	5	7
384	R:R:N117	R:R:S124	1.49	No	No	0	4	6
385	R:R:L156	R:R:V383	1.49	No	No	0	6	5
386	R:R:L287	R:R:V283	1.49	No	No	4	4	4
387	R:R:L287	R:R:V308	1.49	No	No	4	4	8
388	R:R:L305	R:R:V308	1.49	Yes	No	4	2	8
389	R:R:L351	R:R:V332	1.49	No	No	0	9	6
390	R:R:N375	R:R:V376	1.48	No	No	0	5	4
391	R:R:I201	R:R:I205	1.47	No	No	0	4	6
392	R:R:D301	R:R:T294	1.45	No	No	0	4	3
393	R:R:E213	R:R:S216	1.44	No	No	0	3	2
394	R:R:I327	R:R:L251	1.43	No	No	0	9	9
395	R:R:I330	R:R:L255	1.43	No	No	0	8	8
396	R:R:I347	R:R:L335	1.43	No	No	0	7	8
397	R:R:K154	R:R:L151	1.41	No	No	0	5	2
398	R:R:L169	R:R:M197	1.41	No	No	0	4	7
399	R:R:A370	R:R:F371	1.39	No	No	0	6	4
400	R:R:L169	R:R:L170	1.38	No	No	0	4	5
401	R:R:L251	R:R:L255	1.38	No	No	0	9	8
402	R:R:I330	R:R:Q333	1.37	No	No	0	8	7
403	R:R:I411	R:R:Q408	1.37	No	No	0	5	7
404	R:R:K334	R:R:Q333	1.36	No	No	0	9	7
405	L:L:K9	L:L:Q6	1.36	Yes	No	0	0	0
406	L:L:M37	L:L:Q41	1.36	Yes	No	0	0	0
407	R:R:E36	R:R:M33	1.35	No	No	0	4	4
408	R:R:D87	R:R:Q88	1.31	No	No	0	2	3
409	R:R:F321	R:R:V322	1.31	No	No	0	6	4
410	L:L:H20	R:R:D215	1.26	No	No	0	0	4
411	R:R:F402	R:R:L403	1.22	No	No	0	8	7
412	R:R:L335	R:R:R350	1.21	No	No	0	8	8
413	R:R:D87	R:R:R82	1.19	No	No	0	2	4
414	R:R:K414	R:R:W418	1.16	No	No	0	5	4
415	R:R:E30	R:R:W58	1.09	No	Yes	0	7	7
416	R:R:W415	R:R:W418	0.94	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q31	8.118	5	7	4
2	R:R:C54	5.558	5	1	9
3	R:R:W58	6.998	5	7	7
4	R:R:W64	10.6086	7	1	9
5	R:R:V73	4.635	4	1	8
6	R:R:C118	6.15	4	1	9
7	R:R:W123	11.7467	6	1	9
8	R:R:P126	7.7075	4	1	5
9	R:R:Y130	6.306	5	1	8
10	R:R:F131	7.19833	6	1	4
11	R:R:F136	6.73667	6	0	3
12	R:R:D147	6.1075	4	0	1
13	R:R:Y150	7.95	6	2	4
14	R:R:Y157	6.3825	4	0	8
15	R:R:Y161	4.2025	4	0	7
16	R:R:L175	5.8575	4	0	8
17	R:R:I188	4.0675	4	0	9
18	R:R:F196	7.22	4	0	8
19	R:R:R199	8.34	5	5	8
20	R:R:L210	10.105	4	0	7
21	R:R:Y211	7.35167	6	0	4
22	R:R:I221	5.2925	4	0	3
23	R:R:H234	5.61	4	0	7
24	R:R:Y241	9.22	6	5	7
25	R:R:W243	10.22	6	3	9
26	R:R:F245	4.255	4	0	8
27	R:R:E247	8.1275	4	0	9
28	R:R:Y269	4.8125	4	3	7
29	R:R:W274	8.6825	4	3	8
30	R:R:P277	3.748	5	0	9
31	R:R:R288	9.1925	4	4	8
32	R:R:W297	14.475	4	4	8
33	R:R:M299	4.6675	4	2	5
34	R:R:L305	5.555	4	4	2
35	R:R:W306	8.828	5	10	5
36	R:R:F324	5.586	5	6	9
37	R:R:F362	5.706	5	6	9
38	R:R:I364	4.745	4	6	6
39	R:R:Y366	9.8925	4	5	8
40	R:R:S390	4.4725	4	9	9
41	L:L:K9	2.345	4	11	0
42	L:L:Q25	8.966	5	2	0
43	L:L:Q29	7.075	4	2	0
44	L:L:T35	4.59	4	2	0
45	L:L:M37	4.8225	4	2	0
46	L:L:P43	4.53	4	2	0
47	L:L:M52	3.81833	6	8	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P126	R:R:R116	13.5087	15.85	Yes	No	1	5	9
2	R:R:P126	R:R:Y130	13.9901	8.34	Yes	Yes	1	5	8
3	R:R:V114	R:R:Y130	22.5467	2.52	No	Yes	0	6	8
4	R:R:A133	R:R:V114	22.5413	1.7	No	No	0	6	6
5	R:R:A133	R:R:C77	22.4985	1.81	No	No	0	6	9
6	R:R:C134	R:R:C77	22.4611	7.28	No	No	0	9	9
7	R:R:C134	R:R:F81	22.413	9.78	No	No	0	9	6
8	R:R:F136	R:R:F81	22.199	3.22	Yes	No	0	3	6
9	L:L:F48	L:L:Q15	17.7282	3.51	No	No	0	0	0
10	L:L:I11	L:L:Q15	16.9421	2.74	No	No	0	0	0
11	L:L:I11	L:L:R8	16.1452	6.26	No	No	0	0	0
12	L:L:R8	R:R:N60	12.0006	4.82	No	No	0	0	6
13	L:L:M52	R:R:F136	12.4338	4.98	Yes	Yes	0	0	3
14	L:L:F7	R:R:Y130	12.2092	7.22	No	Yes	1	0	8
15	L:L:F7	R:R:F131	11.161	7.5	No	Yes	1	0	4
16	L:L:L24	R:R:Y150	10.1984	8.21	No	Yes	0	0	4
17	L:L:Q25	R:R:Y150	21.3273	16.91	Yes	Yes	2	0	4
18	L:L:M37	L:L:Q25	29.7235	5.44	Yes	Yes	2	0	0
19	L:L:M37	R:R:M299	46.7939	4.33	Yes	Yes	2	0	5
20	R:R:D298	R:R:M299	56.7624	4.16	No	Yes	0	6	5
21	R:R:D298	R:R:Y211	57.9764	5.75	No	Yes	0	6	4
22	R:R:L210	R:R:Y211	88.2347	19.93	Yes	Yes	0	7	4
23	R:R:D207	R:R:L210	82.3466	6.79	No	Yes	0	7	7
24	R:R:D207	R:R:V203	83.0847	5.84	No	No	0	7	7
25	L:L:T31	R:R:V203	26.3704	4.76	No	No	0	0	7
26	L:L:T31	R:R:Y157	24.996	7.49	No	Yes	0	0	8
27	R:R:T158	R:R:Y157	13.6157	4.99	No	Yes	0	7	8
28	R:R:F204	R:R:T158	12.145	3.89	No	No	0	7	7
29	R:R:V203	R:R:Y161	95.3794	3.79	No	Yes	0	7	7
30	R:R:S390	R:R:Y161	10.6262	2.54	Yes	Yes	0	9	7
31	R:R:R199	R:R:Y161	100	5.14	Yes	Yes	0	8	7
32	R:R:N240	R:R:R199	58.955	9.64	No	Yes	0	9	8
33	R:R:F196	R:R:N240	56.88	10.87	Yes	No	0	8	9
34	R:R:F196	R:R:V396	53.6499	2.62	Yes	No	0	8	9
35	R:R:F193	R:R:V396	52.5215	3.93	No	No	0	8	9
36	R:R:F193	R:R:L175	45.4998	2.44	No	Yes	0	8	8
37	R:R:L175	R:R:N186	30.3171	8.24	Yes	No	0	8	9
38	R:R:N186	R:R:R185	28.9802	4.82	No	No	0	9	9
39	R:R:N404	R:R:R185	26.2741	2.41	No	No	0	9	9
40	R:R:N404	R:R:V407	23.5253	8.87	No	No	0	9	9
41	R:R:L181	R:R:V407	22.1349	5.96	No	No	0	9	9
42	R:R:F178	R:R:L181	15.0222	2.44	No	No	0	6	9
43	R:R:F178	R:R:I411	12.1023	3.77	No	No	0	6	5
44	R:R:R199	R:R:Y241	98.5668	10.29	Yes	Yes	5	8	7
45	R:R:I317	R:R:Y241	97.9785	3.63	No	Yes	0	7	7
46	R:R:I317	R:R:S316	97.433	4.64	No	No	0	7	7
47	R:R:F245	R:R:S316	96.8768	5.28	Yes	No	0	8	7
48	R:R:F242	R:R:F245	48.8529	4.29	No	Yes	0	5	8
49	R:R:F242	R:R:P277	43.6387	7.22	No	Yes	0	5	9
50	R:R:G273	R:R:P277	39.5315	4.06	No	Yes	0	9	9
51	R:R:G273	R:R:W243	38.6759	5.63	No	Yes	0	9	9
52	R:R:I188	R:R:W243	15.573	3.52	Yes	Yes	0	9	9
53	R:R:F245	R:R:N320	51.0027	4.83	Yes	No	0	8	9
54	R:R:F362	R:R:N320	50.1257	6.04	Yes	No	0	9	9
55	R:R:F362	R:R:L361	23.7125	7.31	Yes	No	0	9	9
56	R:R:E247	R:R:L361	18.9368	11.93	Yes	No	0	9	9
57	R:R:E247	R:R:I188	15.8244	4.1	Yes	Yes	0	9	9
58	R:R:F266	R:R:I188	10.284	5.02	No	Yes	0	6	9
59	R:R:C236	R:R:F232	13.2948	6.98	No	No	0	5	4
60	R:R:F232	R:R:K206	12.7814	9.93	No	No	0	4	6
61	R:R:K206	R:R:V229	13.1504	6.07	No	No	0	6	6
62	R:R:L210	R:R:V229	15.557	8.94	Yes	No	0	7	6
63	R:R:R199	R:R:V237	41.6974	10.46	Yes	No	0	8	6
64	R:R:F233	R:R:V237	40.4941	3.93	No	No	0	6	6
65	R:R:C236	R:R:S202	14.589	3.44	No	No	0	5	6
66	R:R:F233	R:R:S202	15.327	6.61	No	No	0	6	6
67	R:R:Q214	R:R:Y211	30.8091	3.38	No	Yes	0	2	4
68	L:L:H19	L:L:N22	11.4659	7.65	No	No	0	0	0
69	L:L:H19	R:R:F220	13.9366	4.53	No	No	0	0	3
70	R:R:F220	R:R:Q214	15.2201	8.2	No	No	0	3	2
71	R:R:I221	R:R:Q214	16.894	5.49	Yes	No	0	3	2
72	R:R:F233	R:R:H234	44.6494	7.92	No	Yes	0	6	7
73	R:R:H234	R:R:W284	29.1192	5.29	Yes	No	0	7	8
74	R:R:R288	R:R:W284	24.258	15.99	Yes	No	0	8	8
75	R:R:H234	R:R:W306	12.9472	5.29	Yes	Yes	0	7	5
76	R:R:I246	R:R:W243	27.2261	12.92	No	Yes	3	8	9
77	R:R:I246	R:R:Y269	24.4505	4.84	No	Yes	3	8	7
78	R:R:T253	R:R:Y269	16.2308	3.75	No	Yes	0	7	7
79	R:R:T253	R:R:V256	14.8083	3.17	No	No	0	7	6
80	R:R:E257	R:R:V256	13.375	2.85	No	No	0	5	6
81	R:R:E257	R:R:F260	11.9311	4.66	No	No	0	5	6
82	R:R:L305	R:R:R288	11.4177	6.07	Yes	Yes	4	2	8
83	R:R:F324	R:R:F362	26.6859	4.29	Yes	Yes	6	9	9
84	R:R:F324	R:R:I328	15.9955	6.28	Yes	No	0	9	7
85	R:R:I328	R:R:T355	14.5944	1.52	No	No	0	7	9
86	R:R:S354	R:R:T355	13.1825	3.2	No	No	0	9	9
87	R:R:L351	R:R:S354	10.3268	3	No	No	0	9	9
88	R:R:I411	R:R:Q408	10.6262	1.37	No	No	0	5	7
89	L:L:G44	L:L:P43	12.0381	2.03	No	Yes	0	0	0
90	L:L:M37	L:L:Q29	11.8883	8.16	Yes	Yes	2	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K28	R:R:N60	8.39	0	No	No	3	6	2	1
R:R:N60	R:R:W58	7.91	0	No	Yes	6	7	1	2
L:L:R8	R:R:N60	4.82	0	No	No	0	6	0	1
R:R:I61	R:R:Y130	8.46	0	No	Yes	4	8	2	1
R:R:F136	R:R:F84	5.36	0	Yes	No	3	5	1	1
L:L:N45	R:R:F84	6.04	0	No	No	0	5	0	1
L:L:F48	R:R:F84	6.43	0	No	No	0	5	0	1
R:R:P126	R:R:R116	15.85	1	Yes	No	5	9	1	2
R:R:P126	R:R:Y130	8.34	1	Yes	Yes	5	8	1	1
L:L:T4	R:R:P126	3.5	1	No	Yes	0	5	0	1
R:R:F131	R:R:H129	13.58	1	Yes	No	4	2	1	1
R:R:D132	R:R:H129	3.78	1	No	No	6	2	2	1
L:L:T4	R:R:Y130	4.99	1	No	Yes	0	8	0	1
L:L:F7	R:R:Y130	7.22	1	No	Yes	0	8	0	1
R:R:D132	R:R:F131	7.17	1	No	Yes	6	4	2	1
L:L:F7	R:R:F131	7.5	1	No	Yes	0	4	0	1
L:L:F59	R:R:F131	7.5	1	No	Yes	0	4	0	1
L:L:K60	R:R:F131	4.96	0	No	Yes	0	4	0	1
R:R:F136	R:R:G135	4.52	0	Yes	No	3	3	1	2
L:L:K49	R:R:F136	13.65	0	No	Yes	0	3	0	1
L:L:M52	R:R:F136	4.98	8	Yes	Yes	0	3	0	1
L:L:K53	R:R:F136	8.69	0	No	Yes	0	3	0	1
R:R:D145	R:R:D147	13.31	0	No	Yes	1	1	2	1
R:R:Q146	R:R:Y150	3.38	0	No	Yes	1	4	2	1
L:L:S21	R:R:D147	5.89	0	No	Yes	0	1	0	1
R:R:Y149	R:R:Y150	6.95	0	No	Yes	4	4	2	1
R:R:R379	R:R:Y150	7.2	2	No	Yes	4	4	1	1
L:L:L24	R:R:Y150	8.21	0	No	Yes	0	4	0	1
L:L:Q25	R:R:Y150	16.91	2	Yes	Yes	0	4	0	1
L:L:V28	R:R:Y150	5.05	0	No	Yes	0	4	0	1
R:R:K154	R:R:Y157	8.36	0	No	Yes	5	8	2	1
R:R:T158	R:R:Y157	4.99	0	No	Yes	7	8	2	1
R:R:L386	R:R:Y157	4.69	0	No	Yes	8	8	2	1
L:L:T31	R:R:Y157	7.49	0	No	Yes	0	8	0	1
R:R:R199	R:R:Y161	5.14	5	Yes	Yes	8	7	2	2
R:R:V203	R:R:Y161	3.79	0	No	Yes	7	7	1	2
R:R:R199	R:R:Y241	10.29	5	Yes	Yes	8	7	2	1
R:R:R199	R:R:Y366	6.17	5	Yes	Yes	8	8	2	2
R:R:D207	R:R:V203	5.84	0	No	No	7	7	2	1
L:L:T31	R:R:V203	4.76	0	No	No	0	7	0	1
R:R:D207	R:R:L210	6.79	0	No	Yes	7	7	2	2
R:R:L210	R:R:Y211	19.93	0	Yes	Yes	7	4	2	1
R:R:Q214	R:R:Y211	3.38	0	No	Yes	2	4	2	1
R:R:D298	R:R:Y211	5.75	0	No	Yes	6	4	2	1
L:L:T26	R:R:Y211	6.24	0	No	Yes	0	4	0	1
L:L:S27	R:R:Y211	3.82	0	No	Yes	0	4	0	1
L:L:T30	R:R:Y211	4.99	0	No	Yes	0	4	0	1
R:R:F220	R:R:Q214	8.2	0	No	No	3	2	1	2
L:L:H19	R:R:F220	4.53	0	No	No	0	3	0	1
R:R:H234	R:R:W306	5.29	0	Yes	Yes	7	5	2	1
R:R:V313	R:R:Y241	11.36	0	No	Yes	7	7	2	1
R:R:I317	R:R:Y241	3.63	0	No	Yes	7	7	2	1
R:R:Y241	R:R:Y366	14.89	5	Yes	Yes	7	8	1	2
L:L:T33	R:R:Y241	9.99	5	No	Yes	0	7	0	1
L:L:F34	R:R:Y241	5.16	5	No	Yes	0	7	0	1
R:R:D298	R:R:M299	4.16	0	No	Yes	6	5	2	1
R:R:D301	R:R:M299	4.16	2	No	Yes	4	5	1	1
L:L:M37	R:R:M299	4.33	2	Yes	Yes	0	5	0	1
L:L:T39	R:R:M299	6.02	2	No	Yes	0	5	0	1
R:R:N300	R:R:W306	11.3	10	No	Yes	6	5	1	1
L:L:S36	R:R:N300	5.96	10	No	No	0	6	0	1
L:L:T39	R:R:D301	8.67	2	No	No	0	4	0	1
R:R:I309	R:R:W306	3.52	0	No	Yes	7	5	2	1
R:R:K310	R:R:W306	10.44	0	No	Yes	6	5	2	1
L:L:S36	R:R:W306	13.59	10	No	Yes	0	5	0	1
R:R:E374	R:R:R381	5.82	0	No	No	4	7	2	1
R:R:K378	R:R:R381	4.95	0	No	No	5	7	2	1
L:L:Q25	R:R:R379	8.18	2	Yes	No	0	4	0	1
L:L:T35	R:R:R381	5.17	2	Yes	No	0	7	0	1
L:L:Q29	R:R:L382	6.65	2	Yes	No	0	5	0	1
L:L:T35	R:R:L382	4.42	2	Yes	No	0	5	0	1
R:R:F136	R:R:F81	3.22	0	Yes	No	3	6	1	2
R:R:E125	R:R:P126	3.14	0	No	Yes	4	5	2	1
L:L:A3	R:R:H129	2.93	0	No	No	0	2	0	1
L:L:F34	R:R:A370	2.77	5	No	No	0	6	0	1
L:L:L24	R:R:D147	2.71	0	No	Yes	0	1	0	1
R:R:V114	R:R:Y130	2.52	0	No	Yes	6	8	2	1
L:L:H20	R:R:D147	2.52	0	No	Yes	0	1	0	1
L:L:K56	R:R:F131	2.48	0	No	Yes	0	4	0	1
R:R:D301	R:R:T294	1.45	2	No	No	4	3	1	2
R:R:A370	R:R:F371	1.39	0	No	No	6	4	1	2
L:L:H20	R:R:D215	1.26	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6M1H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	384
Number of Links	416
Number of Hubs	47
Number of Links mediated by Hubs	187
Number of Communities	11
Number of Nodes involved in Communities	70
Number of Links involved in Communities	89

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	50037
Length Of Smallest Path	3
Average Path Length	14.8419
Length of Longest Path	38
Minimum Path Strength	1.05
Average Path Strength	6.10673
Maximum Path Strength	21.74
Minimum Path Correlation	0.7
Average Path Correlation	0.969104
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	71.2244
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.5544
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• small GTPase binding • protein binding • binding • enzyme binding • GTPase binding • molecular transducer activity • signaling receptor activity • adenylate cyclase binding • vasoactive intestinal polypeptide receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • response to stimulus • response to chemical • response to xenobiotic stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • cellular process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal process • response to stress • multicellular organismal response to stress • response to alcohol • response to oxygen-containing compound • response to ethanol • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • intracellular signal transduction • cAMP/PKA signal transduction • intracellular signaling cassette • regulation of localization • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • transport • monoatomic ion transmembrane transport • positive regulation of biological process • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • regulation of calcium ion transmembrane transport • localization • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • regulation of biological quality • monoatomic cation transport • regulation of metal ion transport • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • transmembrane transport • positive regulation of calcium ion transport into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • calcium ion transport into cytosol • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of small GTPase mediated signal transduction • multicellular organism development • development of primary sexual characteristics • sex differentiation • anatomical structure development • female sex differentiation • development of primary female sexual characteristics • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • response to lipid • response to estradiol • negative regulation of response to reactive oxygen species • negative regulation of response to stimulus • negative regulation of biological process • response to reactive oxygen species • response to oxidative stress • regulation of response to reactive oxygen species • regulation of response to stress • regulation of response to oxidative stress • negative regulation of response to oxidative stress • cell surface • cellular anatomical structure • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • membrane • plasma membrane • plasma membrane region • caveola • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle
Gene Ontology	Cellular Component	• cell surface • cellular anatomical structure • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • membrane • plasma membrane • plasma membrane region • caveola • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • protein-containing complex • receptor complex • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • cytoplasm • vesicle • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction • cell junction • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • biological regulation • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • regulation of biological quality • vasodilation • blood circulation • regulation of anatomical structure size • extracellular region • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41586
Sequence	>6M1H_nogp_Chain_R K K E Q A M C L E K G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q D M G V V S R N C T E D G W S E P F P H Y F D A C G F D Q D Y Y Y L S V K A L Y T V G Y S L S L V A L L L A M V I L C R F R K L H C T R N F I H M N L F V S F M L R A I S V F I K D W I L Y A E Q D S N H C F I S T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E T F F P E R R Y F Y W Y T I I G W G A P L V F V T V W A T L R L Y F D D T G C W D M N D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L Q S P D I Y L R L A R S T L L L I P L F G I H Y T V F A F S P E N V S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E V Q A E I K R K W R S W K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8E3X	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	10.1038/s41467-022-34629-3
	8E3X (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	10.1038/s41467-022-34629-3
	6LPB	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ1	3.9	2020-03-11	10.1038/s41594-020-0386-8
	6LPB (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.9	2020-03-11	10.1038/s41594-020-0386-8
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.5	2020-03-11	10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.5	2020-03-11	10.1038/s41422-020-0280-2
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	10.1038/s41422-020-0280-2
	6P9Y	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.01	2020-02-05	10.1016/j.molcel.2020.01.012
	6P9Y (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.01	2020-02-05	10.1016/j.molcel.2020.01.012

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