psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:V237	12.45	Yes	No	0	0	6
2	L:L:H1	R:R:W306	5.29	Yes	Yes	0	0	5
3	L:L:H1	R:R:V313	6.92	Yes	No	0	0	7
4	L:L:S2	R:R:L386	6.01	No	No	0	0	8
5	L:L:D3	R:R:Y161	9.2	Yes	Yes	1	0	7
6	L:L:D3	R:R:R199	4.76	Yes	Yes	1	0	8
7	L:L:D3	R:R:F233	4.78	Yes	Yes	0	0	6
8	L:L:D3	R:R:L386	8.14	Yes	No	0	0	8
9	L:L:I5	R:R:K378	5.82	No	No	0	0	5
10	L:L:I5	R:R:R381	6.26	No	No	0	0	7
11	L:L:F6	L:L:Y10	6.19	Yes	Yes	1	0	0
12	L:L:F6	R:R:Y150	5.16	Yes	Yes	1	0	4
13	L:L:F6	R:R:K154	6.2	Yes	Yes	1	0	5
14	L:L:F6	R:R:Y157	9.28	Yes	Yes	1	0	8
15	L:L:T7	R:R:K206	4.5	No	Yes	0	0	6
16	L:L:D8	L:L:R12	8.34	No	No	0	0	0
17	L:L:S9	R:R:K378	9.18	No	No	0	0	5
18	L:L:R14	L:L:Y10	13.38	No	Yes	1	0	0
19	L:L:Y10	R:R:Y150	8.94	Yes	Yes	1	0	4
20	L:L:Y10	R:R:Y211	17.87	Yes	Yes	1	0	4
21	L:L:S11	R:R:Y211	5.09	No	Yes	0	0	4
22	L:L:S11	R:R:D298	11.78	No	No	0	0	6
23	L:L:R12	R:R:D301	10.72	No	No	0	0	4
24	L:L:M17	L:L:Y13	11.97	No	No	0	0	0
25	L:L:Y13	R:R:Y148	18.86	No	No	1	0	1
26	L:L:Y13	R:R:Y150	9.93	No	Yes	1	0	4
27	L:L:R14	R:R:Y211	15.43	No	Yes	1	0	4
28	L:L:K15	R:R:M299	4.32	No	No	0	0	5
29	L:L:L23	L:L:Y22	4.69	No	No	0	0	0
30	R:R:Y148	R:R:Y150	4.96	No	Yes	1	1	4
31	R:R:Y149	R:R:Y150	4.96	Yes	Yes	0	4	4
32	R:R:V153	R:R:Y149	5.05	No	Yes	0	6	4
33	R:R:R379	R:R:Y149	17.49	No	Yes	0	4	4
34	R:R:K154	R:R:Y157	7.17	Yes	Yes	1	5	8
35	R:R:D207	R:R:K154	9.68	Yes	Yes	1	7	5
36	R:R:G387	R:R:L156	5.13	No	No	0	5	6
37	R:R:Y157	R:R:Y161	7.94	Yes	Yes	1	8	7
38	R:R:V203	R:R:Y157	5.05	No	Yes	1	7	8
39	R:R:D207	R:R:Y157	9.2	Yes	Yes	1	7	8
40	R:R:F391	R:R:G160	9.03	No	No	0	7	9
41	R:R:R199	R:R:Y161	9.26	Yes	Yes	1	8	7
42	R:R:V203	R:R:Y161	10.09	No	Yes	1	7	7
43	R:R:S390	R:R:Y161	6.36	No	Yes	0	9	7
44	R:R:F204	R:R:S162	5.28	No	No	0	7	7
45	R:R:I201	R:R:L165	4.28	No	No	0	4	7
46	R:R:F394	R:R:T167	6.49	No	No	0	5	7
47	R:R:F193	R:R:L168	8.53	No	No	0	8	9
48	R:R:M197	R:R:T169	9.03	No	No	0	7	4
49	R:R:M172	R:R:M190	7.22	No	Yes	5	6	6
50	R:R:L175	R:R:M190	4.24	No	Yes	0	8	6
51	R:R:F178	R:R:R177	11.76	Yes	No	0	6	3
52	R:R:E410	R:R:F178	4.66	Yes	Yes	6	8	6
53	R:R:F178	R:R:I411	5.02	Yes	No	0	6	5
54	R:R:F178	R:R:K414	13.65	Yes	No	6	6	5
55	R:R:H182	R:R:R179	12.41	No	No	0	8	8
56	R:R:E410	R:R:K180	16.2	Yes	No	0	8	7
57	R:R:L181	R:R:V407	8.94	No	No	0	9	9
58	R:R:E410	R:R:L181	9.28	Yes	No	0	8	9
59	R:R:T184	R:R:Y250	4.99	No	Yes	7	7	8
60	R:R:R263	R:R:T184	7.76	No	No	7	4	7
61	R:R:F266	R:R:T184	5.19	No	No	0	6	7
62	R:R:N186	R:R:R185	8.44	No	No	0	9	9
63	R:R:F187	R:R:M190	4.98	No	Yes	0	6	6
64	R:R:F187	R:R:F266	5.36	No	No	0	6	6
65	R:R:E247	R:R:I188	5.47	Yes	No	0	9	9
66	R:R:F266	R:R:I188	5.02	No	No	0	6	9
67	R:R:E247	R:R:H189	9.85	Yes	No	0	9	9
68	R:R:H189	R:R:Y400	4.36	No	No	0	9	9
69	R:R:N191	R:R:W243	14.69	No	Yes	4	8	9
70	R:R:N191	R:R:W274	4.52	No	Yes	4	8	8
71	R:R:F196	R:R:L192	9.74	Yes	No	2	8	9
72	R:R:L192	R:R:L244	4.15	No	No	2	9	9
73	R:R:E247	R:R:L192	7.95	Yes	No	0	9	9
74	R:R:S195	R:R:S239	4.89	Yes	No	4	9	8
75	R:R:N240	R:R:S195	5.96	No	Yes	0	9	9
76	R:R:S195	R:R:W243	7.41	Yes	Yes	4	9	9
77	R:R:S195	R:R:W274	6.18	Yes	Yes	4	9	8
78	R:R:F196	R:R:N240	16.92	Yes	No	0	8	9
79	R:R:F196	R:R:L244	4.87	Yes	No	2	8	9
80	R:R:F196	R:R:Q392	7.03	Yes	Yes	2	8	9
81	R:R:F196	R:R:G393	9.03	Yes	No	0	8	9
82	R:R:F196	R:R:V396	5.24	Yes	No	0	8	9
83	R:R:C236	R:R:L198	6.35	No	No	0	5	7
84	R:R:R199	R:R:V237	9.15	Yes	No	0	8	6
85	R:R:N240	R:R:R199	12.05	No	Yes	0	9	8
86	R:R:R199	R:R:Y241	13.38	Yes	No	0	8	7
87	R:R:F232	R:R:S202	6.61	No	No	8	4	6
88	R:R:C236	R:R:S202	5.16	No	No	8	5	6
89	R:R:K206	R:R:V203	6.07	Yes	No	1	6	7
90	R:R:D207	R:R:K206	11.06	Yes	Yes	1	7	6
91	R:R:K206	R:R:L210	4.23	Yes	Yes	1	6	7
92	R:R:K206	R:R:M230	4.32	Yes	No	1	6	6
93	R:R:F233	R:R:K206	16.13	Yes	Yes	0	6	6
94	R:R:D207	R:R:Y211	6.9	Yes	Yes	1	7	4
95	R:R:I209	R:R:W208	12.92	Yes	No	0	5	4
96	R:R:E225	R:R:I209	12.3	No	Yes	0	5	5
97	R:R:I209	R:R:V229	7.68	Yes	No	0	5	6
98	R:R:L210	R:R:Y211	10.55	Yes	Yes	1	7	4
99	R:R:L210	R:R:M230	8.48	Yes	No	1	7	6
100	R:R:D298	R:R:L210	10.86	No	Yes	0	6	7
101	R:R:K227	R:R:S222	4.59	No	No	0	7	6
102	R:R:C226	R:R:C296	7.28	No	No	0	9	9
103	R:R:D293	R:R:K227	5.53	No	No	1	6	7
104	R:R:K227	R:R:W297	13.92	No	Yes	1	7	8
105	R:R:M230	R:R:W297	4.65	No	Yes	1	6	8
106	R:R:C236	R:R:F232	5.59	No	No	8	5	4
107	R:R:F233	R:R:H234	7.92	Yes	Yes	0	6	7
108	R:R:H234	R:R:W284	14.81	Yes	Yes	1	7	8
109	R:R:H234	R:R:W306	6.35	Yes	Yes	1	7	5
110	R:R:H234	R:R:I309	11.93	Yes	No	1	7	7
111	R:R:W274	R:R:Y235	6.75	Yes	No	0	8	9
112	R:R:P277	R:R:Y235	4.17	No	No	0	9	9
113	R:R:T278	R:R:Y235	6.24	No	No	0	4	9
114	R:R:P277	R:R:V238	5.3	No	No	0	9	6
115	R:R:V238	R:R:V313	4.81	No	No	0	6	7
116	R:R:S239	R:R:W274	4.94	No	Yes	4	8	8
117	R:R:V313	R:R:Y241	11.36	No	No	0	7	7
118	R:R:Y241	R:R:Y366	15.89	No	Yes	0	7	8
119	R:R:F242	R:R:T276	5.19	No	No	0	5	4
120	R:R:I246	R:R:W243	5.87	Yes	Yes	0	8	9
121	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
122	R:R:W243	R:R:W274	22.49	Yes	Yes	4	9	8
123	R:R:L244	R:R:Q392	7.99	No	Yes	2	9	9
124	R:R:F245	R:R:I246	5.02	No	Yes	0	8	8
125	R:R:F245	R:R:S316	5.28	No	No	0	8	7
126	R:R:F245	R:R:V319	6.55	No	No	0	8	6
127	R:R:I246	R:R:Y269	8.46	Yes	Yes	0	8	7
128	R:R:I246	R:R:I272	7.36	Yes	No	0	8	6
129	R:R:E247	R:R:L361	13.25	Yes	No	0	9	9
130	R:R:F362	R:R:G248	9.03	Yes	No	0	9	9
131	R:R:L249	R:R:Y269	7.03	No	Yes	0	6	7
132	R:R:L249	R:R:L323	4.15	No	No	0	6	8
133	R:R:L254	R:R:Y250	14.07	No	Yes	0	7	8
134	R:R:R263	R:R:Y250	5.14	No	Yes	7	4	8
135	R:R:L251	R:R:L255	4.15	No	No	3	9	8
136	R:R:I327	R:R:L251	7.14	No	No	3	9	9
137	R:R:F252	R:R:V256	5.24	No	No	0	7	6
138	R:R:F252	R:R:L323	12.18	No	No	0	7	8
139	R:R:T253	R:R:Y269	4.99	No	Yes	0	7	7
140	R:R:I327	R:R:L255	4.28	No	No	3	9	8
141	R:R:I330	R:R:L255	5.71	No	No	0	8	8
142	R:R:E257	R:R:F260	4.66	No	No	0	5	6
143	R:R:P261	R:R:R263	7.21	No	No	0	7	4
144	R:R:E262	R:R:Y265	10.1	No	No	0	6	4
145	R:R:R264	R:R:Y267	8.23	No	No	0	5	3
146	R:R:R264	R:R:W268	8	No	No	0	5	3
147	R:R:Y265	R:R:Y269	6.95	No	Yes	0	4	7
148	R:R:I272	R:R:T276	4.56	No	No	0	6	4
149	R:R:R288	R:R:W284	8	Yes	Yes	1	8	8
150	R:R:W284	R:R:W297	7.5	Yes	Yes	1	8	8
151	R:R:I309	R:R:W284	9.4	No	Yes	1	7	8
152	R:R:L287	R:R:L305	5.54	No	No	0	4	2
153	R:R:R288	R:R:W297	13	Yes	Yes	1	8	8
154	R:R:L305	R:R:R288	4.86	No	Yes	0	2	8
155	R:R:L289	R:R:W297	5.69	No	Yes	0	3	8
156	R:R:D292	R:R:S302	7.36	No	No	0	5	5
157	R:R:D293	R:R:W297	6.7	No	Yes	1	6	8
158	R:R:D298	R:R:M299	4.16	No	No	0	6	5
159	R:R:D301	R:R:M299	4.16	No	No	0	4	5
160	R:R:N300	R:R:W306	15.82	No	Yes	0	6	5
161	R:R:L305	R:R:S302	7.51	No	No	0	2	5
162	R:R:I309	R:R:W306	5.87	No	Yes	1	7	5
163	R:R:K310	R:R:W306	9.28	Yes	Yes	0	6	5
164	R:R:K310	R:R:W307	6.96	Yes	No	0	6	6
165	R:R:G311	R:R:W307	5.63	No	No	0	4	6
166	R:R:K310	R:R:V314	4.55	Yes	No	0	6	4
167	R:R:E374	R:R:K310	5.4	No	Yes	0	4	6
168	R:R:F371	R:R:V314	7.87	No	No	0	4	4
169	R:R:I317	R:R:Y366	4.84	No	Yes	0	7	8
170	R:R:F371	R:R:M318	8.71	No	No	0	4	4
171	R:R:F362	R:R:N320	7.25	Yes	No	0	9	9
172	R:R:F321	R:R:T367	7.78	No	No	0	6	6
173	R:R:F324	R:R:I328	7.54	Yes	No	0	9	7
174	R:R:F324	R:R:L358	6.09	Yes	No	3	9	9
175	R:R:F324	R:R:F362	5.36	Yes	Yes	3	9	9
176	R:R:F324	R:R:I364	13.82	Yes	No	0	9	6
177	R:R:I328	R:R:T355	4.56	No	No	0	7	9
178	R:R:L331	R:R:S354	4.5	No	No	0	9	9
179	R:R:L335	R:R:L351	4.15	No	Yes	0	8	9
180	R:R:L349	R:R:S346	4.5	No	No	0	6	6
181	R:R:L357	R:R:R353	4.86	No	No	0	8	8
182	R:R:L357	R:R:L399	4.15	No	No	0	8	8
183	R:R:F362	R:R:L358	8.53	Yes	No	3	9	9
184	R:R:I359	R:R:I364	7.36	No	No	0	8	6
185	R:R:P360	R:R:V395	5.3	No	No	0	9	6
186	R:R:F362	R:R:L361	7.31	Yes	No	0	9	9
187	R:R:L361	R:R:Y400	24.62	No	No	0	9	9
188	R:R:H365	R:R:Y366	15.24	No	Yes	2	9	8
189	R:R:H365	R:R:Q392	12.36	No	Yes	2	9	9
190	R:R:E385	R:R:Y366	8.98	No	Yes	2	8	8
191	R:R:Q392	R:R:Y366	5.64	Yes	Yes	2	9	8
192	R:R:F384	R:R:V368	6.55	No	No	0	3	6
193	R:R:F369	R:R:R381	13.9	No	No	2	6	7
194	R:R:F369	R:R:F384	7.5	No	No	0	6	3
195	R:R:E385	R:R:F369	8.16	No	No	2	8	6
196	R:R:N375	R:R:P373	4.89	No	No	0	5	8
197	R:R:P373	R:R:V376	8.84	No	No	0	8	4
198	R:R:E380	R:R:S377	8.62	No	No	0	5	5
199	R:R:E385	R:R:R381	9.3	No	No	2	8	7
200	R:R:F384	R:R:L388	4.87	No	No	0	3	7
201	R:R:E406	R:R:N404	9.2	No	No	0	9	9
202	R:R:N404	R:R:V407	5.91	No	No	0	9	9
203	R:R:E410	R:R:K414	6.75	Yes	No	6	8	5
204	R:R:K414	R:R:R413	16.09	No	No	0	5	7
205	R:R:R185	R:R:Y250	4.12	No	Yes	0	9	8
206	R:R:I347	R:R:Q336	4.12	No	No	0	7	7
207	R:R:G311	R:R:P312	4.06	No	No	0	4	9
208	R:R:A200	R:R:Y161	4	No	Yes	0	8	7
209	R:R:R416	R:R:W415	4	No	No	0	4	5
210	R:R:F233	R:R:S202	3.96	Yes	No	0	6	6
211	R:R:F193	R:R:V396	3.93	No	No	0	8	9
212	R:R:F394	R:R:V398	3.93	No	No	0	5	5
213	R:R:F204	R:R:T158	3.89	No	No	0	7	7
214	R:R:F402	R:R:T170	3.89	Yes	No	0	8	5
215	R:R:V383	R:R:Y149	3.79	No	Yes	0	5	4
216	R:R:F402	R:R:I174	3.77	Yes	No	0	8	8
217	R:R:C280	R:R:P312	3.77	No	No	0	5	9
218	R:R:F324	R:R:I325	3.77	Yes	No	0	9	5
219	R:R:G160	R:R:S390	3.71	No	No	0	9	9
220	R:R:G295	R:R:S222	3.71	No	No	0	4	6
221	R:R:V194	R:R:W274	3.68	No	Yes	0	4	8
222	R:R:L335	R:R:R350	3.64	No	No	0	8	8
223	R:R:I347	R:R:Y348	3.63	No	No	0	7	7
224	R:R:A171	R:R:C401	3.61	No	No	0	9	9
225	R:R:P338	R:R:S337	3.56	No	No	0	6	7
226	R:R:P373	R:R:S372	3.56	No	No	0	8	5
227	L:L:Y10	R:R:L151	3.52	Yes	No	0	0	2
228	R:R:L382	R:R:Y149	3.52	No	Yes	0	5	4
229	R:R:I205	R:R:W208	3.52	No	No	0	6	4
230	L:L:Q16	L:L:R12	3.5	No	No	0	0	0
231	R:R:G315	R:R:M318	3.49	No	No	0	4	4
232	R:R:F187	R:R:H182	3.39	No	No	0	6	8
233	R:R:I359	R:R:P360	3.39	No	No	0	8	9
234	R:R:G363	R:R:Q392	3.29	No	Yes	0	9	9
235	R:R:C401	R:R:I174	3.27	No	No	0	9	8
236	R:R:C226	R:R:I209	3.27	No	Yes	0	9	5
237	R:R:C176	R:R:M172	3.24	No	No	5	4	6
238	R:R:C176	R:R:M190	3.24	No	Yes	5	4	6
239	R:R:F259	R:R:F260	3.22	No	No	0	7	6
240	R:R:V231	R:R:V281	3.21	No	No	0	6	7
241	R:R:V283	R:R:V308	3.21	No	No	0	4	8
242	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
243	R:R:G389	R:R:H365	3.18	No	No	0	7	9
244	R:R:C401	R:R:L175	3.17	No	No	0	9	8
245	R:R:C296	R:R:L210	3.17	No	Yes	0	9	7
246	R:R:A397	R:R:L168	3.15	No	No	0	9	9
247	R:R:F204	R:R:Y161	3.09	No	Yes	0	7	7
248	R:R:I221	R:R:T223	3.04	No	No	0	3	3
249	R:R:I317	R:R:T367	3.04	No	No	0	7	6
250	L:L:L23	L:L:V19	2.98	No	No	0	0	0
251	L:L:L27	L:L:V26	2.98	No	No	0	0	0
252	R:R:L323	R:R:V322	2.98	No	No	0	8	4
253	R:R:L351	R:R:V332	2.98	Yes	No	0	9	6
254	R:R:L399	R:R:V395	2.98	No	No	0	8	6
255	R:R:I174	R:R:I411	2.94	No	No	0	8	5
256	R:R:Q336	R:R:V332	2.87	No	No	0	7	6
257	R:R:E257	R:R:V256	2.85	No	No	0	5	6
258	R:R:I327	R:R:L358	2.85	No	No	3	9	9
259	R:R:L165	R:R:M197	2.83	No	No	0	7	7
260	R:R:L168	R:R:M197	2.83	No	No	0	9	7
261	R:R:E225	R:R:T223	2.82	No	No	0	5	3
262	R:R:L331	R:R:L351	2.77	No	Yes	0	9	9
263	R:R:E213	R:R:K154	2.7	No	Yes	0	3	5
264	R:R:R413	R:R:S417	2.64	No	No	0	7	7
265	R:R:F402	R:R:V398	2.62	Yes	No	0	8	5
266	R:R:F391	R:R:T163	2.59	No	No	0	7	5
267	R:R:S164	R:R:Y161	2.54	No	Yes	0	9	7
268	L:L:V26	L:L:Y22	2.52	No	No	0	0	0
269	R:R:V308	R:R:W284	2.45	No	Yes	0	8	8
270	R:R:F291	R:R:L287	2.44	No	No	0	3	4
271	R:R:T270	R:R:W243	2.43	No	Yes	0	5	9
272	R:R:E380	R:R:R379	2.33	No	No	0	5	4
273	R:R:F291	R:R:Y290	2.06	No	No	0	3	3
274	R:R:G275	R:R:P277	2.03	No	No	0	7	9
275	R:R:G326	R:R:V329	1.84	No	No	0	8	8
276	R:R:C280	R:R:V281	1.71	No	No	0	5	7
277	R:R:G387	R:R:L386	1.71	No	No	0	5	8
278	R:R:A285	R:R:V231	1.7	No	No	0	5	6
279	R:R:G405	R:R:N404	1.7	No	No	0	5	9
280	R:R:A370	R:R:I317	1.62	No	No	0	6	7
281	R:R:A409	R:R:K412	1.61	No	No	0	4	6
282	R:R:T163	R:R:V159	1.59	No	No	0	5	6
283	R:R:T167	R:R:V166	1.59	No	No	0	7	4
284	R:R:C183	R:R:N186	1.57	No	No	0	8	9
285	R:R:T278	R:R:T282	1.57	No	No	0	4	3
286	R:R:T282	R:R:T286	1.57	No	No	0	3	4
287	R:R:I325	R:R:V329	1.54	No	No	0	5	8
288	L:L:K15	L:L:V19	1.52	No	No	0	0	0
289	R:R:A409	R:R:E410	1.51	No	Yes	0	4	8
290	R:R:L351	R:R:T355	1.47	Yes	No	0	9	9
291	R:R:I330	R:R:K334	1.45	No	No	0	8	9
292	R:R:Q333	R:R:V329	1.43	No	No	0	7	8
293	R:R:R288	R:R:T294	1.29	Yes	No	0	8	3
294	R:R:F402	R:R:L403	1.22	Yes	No	0	8	7
295	R:R:I271	R:R:W268	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	6.96	4	0	0
2	L:L:D3	6.72	4	1	0
3	L:L:F6	6.7075	4	1	0
4	L:L:Y10	9.98	5	1	0
5	R:R:Y149	6.962	5	0	4
6	R:R:Y150	6.79	5	1	4
7	R:R:K154	6.4375	4	1	5
8	R:R:Y157	7.728	5	1	8
9	R:R:Y161	6.56	8	1	7
10	R:R:F178	8.7725	4	6	6
11	R:R:M190	4.92	4	5	6
12	R:R:S195	6.11	4	4	9
13	R:R:F196	8.805	6	2	8
14	R:R:R199	9.72	5	1	8
15	R:R:K206	7.71833	6	1	6
16	R:R:D207	9.21	4	1	7
17	R:R:I209	9.0425	4	0	5
18	R:R:L210	7.458	5	1	7
19	R:R:Y211	11.168	5	1	4
20	R:R:F233	8.1975	4	0	6
21	R:R:H234	10.2525	4	1	7
22	R:R:W243	10.2217	6	4	9
23	R:R:I246	6.6775	4	0	8
24	R:R:E247	9.13	4	0	9
25	R:R:Y250	7.08	4	7	8
26	R:R:Y269	6.8575	4	0	7
27	R:R:W274	8.09333	6	4	8
28	R:R:W284	8.432	5	1	8
29	R:R:R288	6.7875	4	1	8
30	R:R:W297	8.57667	6	1	8
31	R:R:W306	8.522	5	1	5
32	R:R:K310	6.5475	4	0	6
33	R:R:F324	7.316	5	3	9
34	R:R:L351	2.8425	4	0	9
35	R:R:F362	7.496	5	3	9
36	R:R:Y366	10.118	5	2	8
37	R:R:Q392	7.262	5	2	9
38	R:R:F402	2.875	4	0	8
39	R:R:E410	7.68	5	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:V237	14.301	12.45	Yes	No	0	0	6
2	R:R:R199	R:R:V237	15.2576	9.15	Yes	No	0	8	6
3	L:L:D3	R:R:R199	47.1035	4.76	Yes	Yes	1	0	8
4	R:R:R199	R:R:Y161	54.2059	9.26	Yes	Yes	1	8	7
5	L:L:H1	R:R:W306	21.895	5.29	Yes	Yes	0	0	5
6	R:R:H234	R:R:W306	16.2249	6.35	Yes	Yes	1	7	5
7	R:R:F233	R:R:H234	29.2807	7.92	Yes	Yes	0	6	7
8	R:R:V313	R:R:Y241	11.2121	11.36	No	No	0	7	7
9	R:R:Y241	R:R:Y366	23.0547	15.89	No	Yes	0	7	8
10	R:R:E385	R:R:Y366	20.4842	8.98	No	Yes	2	8	8
11	L:L:F6	R:R:Y157	19.3138	9.28	Yes	Yes	1	0	8
12	R:R:Y157	R:R:Y161	22.2745	7.94	Yes	Yes	1	8	7
13	L:L:F6	R:R:Y150	16.6524	5.16	Yes	Yes	1	0	4
14	R:R:F233	R:R:K206	38.6917	16.13	Yes	Yes	0	6	6
15	R:R:D298	R:R:M299	24.8343	4.16	No	No	0	6	5
16	R:R:D298	R:R:L210	26.0368	10.86	No	Yes	0	6	7
17	R:R:K206	R:R:L210	43.8702	4.23	Yes	Yes	1	6	7
18	L:L:K15	R:R:M299	13.7345	4.32	No	No	0	0	5
19	L:L:K15	L:L:V19	11.4846	1.52	No	No	0	0	0
20	R:R:Y149	R:R:Y150	14.8087	4.96	Yes	Yes	0	4	4
21	R:R:V203	R:R:Y161	27.8698	10.09	No	Yes	1	7	7
22	R:R:N240	R:R:R199	100	12.05	No	Yes	0	9	8
23	R:R:F196	R:R:N240	92.8976	16.92	Yes	No	0	8	9
24	R:R:F196	R:R:V396	12.2649	5.24	Yes	No	0	8	9
25	R:R:F193	R:R:V396	10.7685	3.93	No	No	0	8	9
26	R:R:F196	R:R:L192	91.1875	9.74	Yes	No	2	8	9
27	R:R:E247	R:R:L192	99.7542	7.95	Yes	No	0	9	9
28	R:R:E247	R:R:I188	61.4258	5.47	Yes	No	0	9	9
29	R:R:F266	R:R:I188	60.1806	5.02	No	No	0	6	9
30	R:R:F187	R:R:F266	48.4769	5.36	No	No	0	6	6
31	R:R:F187	R:R:M190	44.394	4.98	No	Yes	0	6	6
32	R:R:L175	R:R:M190	40.2095	4.24	No	Yes	0	8	6
33	R:R:C401	R:R:L175	38.7933	3.17	No	No	0	9	8
34	R:R:C401	R:R:I174	35.9288	3.27	No	No	0	9	8
35	R:R:F402	R:R:I174	11.5381	3.77	Yes	No	0	8	8
36	R:R:I174	R:R:I411	24.0274	2.94	No	No	0	8	5
37	R:R:F178	R:R:I411	22.5737	5.02	Yes	No	0	6	5
38	R:R:E410	R:R:F178	14.6003	4.66	Yes	Yes	6	8	6
39	R:R:F266	R:R:T184	13.1413	5.19	No	No	0	6	7
40	R:R:E247	R:R:L361	50.7535	13.25	Yes	No	0	9	9
41	R:R:N240	R:R:S195	45.5376	5.96	No	Yes	0	9	9
42	R:R:S195	R:R:W243	33.4652	7.41	Yes	Yes	4	9	9
43	R:R:Q392	R:R:Y366	19.923	5.64	Yes	Yes	2	9	8
44	R:R:K206	R:R:M230	13.1466	4.32	Yes	No	1	6	6
45	R:R:H234	R:R:W284	18.9558	14.81	Yes	Yes	1	7	8
46	R:R:M230	R:R:W297	15.4126	4.65	No	Yes	1	6	8
47	R:R:C296	R:R:L210	19.6184	3.17	No	Yes	0	9	7
48	R:R:C226	R:R:C296	17.4808	7.28	No	No	0	9	9
49	R:R:C226	R:R:I209	15.3324	3.27	No	Yes	0	9	5
50	R:R:I246	R:R:W243	29.1631	5.87	Yes	Yes	0	8	9
51	R:R:I246	R:R:Y269	18.8382	8.46	Yes	Yes	0	8	7
52	R:R:F362	R:R:L361	48.2792	7.31	Yes	No	0	9	9
53	R:R:L249	R:R:Y269	12.7726	7.03	No	Yes	0	6	7
54	R:R:L249	R:R:L323	11.2174	4.15	No	No	0	6	8
55	R:R:R288	R:R:W284	11.025	8	Yes	Yes	1	8	8
56	R:R:L305	R:R:R288	10.544	4.86	No	Yes	0	2	8
57	R:R:K310	R:R:W306	24.519	9.28	Yes	Yes	0	6	5
58	R:R:K310	R:R:W307	13.4245	6.96	Yes	No	0	6	6
59	R:R:G311	R:R:W307	11.5381	5.63	No	No	0	4	6
60	R:R:F324	R:R:F362	35.0898	5.36	Yes	Yes	3	9	9
61	R:R:F324	R:R:I328	17.7907	7.54	Yes	No	0	9	7
62	R:R:F324	R:R:I364	11.4419	13.82	Yes	No	0	9	6
63	R:R:I328	R:R:T355	16.1982	4.56	No	No	0	7	9
64	R:R:L351	R:R:T355	14.6804	1.47	Yes	No	0	9	9
65	L:L:D3	R:R:F233	48.5998	4.78	Yes	Yes	0	0	6
66	R:R:R199	R:R:Y241	18.726	13.38	Yes	No	0	8	7
67	R:R:K206	R:R:V203	29.3769	6.07	Yes	No	1	6	7
68	R:R:F196	R:R:Q392	14.317	7.03	Yes	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:V237	12.45	0	Yes	No	0	6	0	1
L:L:H1	R:R:W306	5.29	0	Yes	Yes	0	5	0	1
L:L:H1	R:R:V313	6.92	0	Yes	No	0	7	0	1
L:L:S2	R:R:L386	6.01	0	No	No	0	8	0	1
L:L:D3	R:R:Y161	9.2	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:R199	4.76	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:F233	4.78	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:L386	8.14	1	Yes	No	0	8	0	1
L:L:I5	R:R:K378	5.82	0	No	No	0	5	0	1
L:L:I5	R:R:R381	6.26	0	No	No	0	7	0	1
L:L:F6	R:R:Y150	5.16	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:K154	6.2	1	Yes	Yes	0	5	0	1
L:L:F6	R:R:Y157	9.28	1	Yes	Yes	0	8	0	1
L:L:T7	R:R:K206	4.5	0	No	Yes	0	6	0	1
L:L:S9	R:R:K378	9.18	0	No	No	0	5	0	1
L:L:Y10	R:R:Y150	8.94	1	Yes	Yes	0	4	0	1
L:L:Y10	R:R:Y211	17.87	1	Yes	Yes	0	4	0	1
L:L:S11	R:R:Y211	5.09	0	No	Yes	0	4	0	1
L:L:S11	R:R:D298	11.78	0	No	No	0	6	0	1
L:L:R12	R:R:D301	10.72	0	No	No	0	4	0	1
L:L:Y13	R:R:Y148	18.86	1	No	No	0	1	0	1
L:L:Y13	R:R:Y150	9.93	1	No	Yes	0	4	0	1
L:L:R14	R:R:Y211	15.43	1	No	Yes	0	4	0	1
L:L:K15	R:R:M299	4.32	0	No	No	0	5	0	1
R:R:Y148	R:R:Y150	4.96	1	No	Yes	1	4	1	1
R:R:Y149	R:R:Y150	4.96	0	Yes	Yes	4	4	2	1
R:R:K154	R:R:Y157	7.17	1	Yes	Yes	5	8	1	1
R:R:D207	R:R:K154	9.68	1	Yes	Yes	7	5	2	1
R:R:Y157	R:R:Y161	7.94	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y157	5.05	1	No	Yes	7	8	2	1
R:R:D207	R:R:Y157	9.2	1	Yes	Yes	7	8	2	1
R:R:R199	R:R:Y161	9.26	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y161	10.09	1	No	Yes	7	7	2	1
R:R:S390	R:R:Y161	6.36	0	No	Yes	9	7	2	1
R:R:R199	R:R:V237	9.15	1	Yes	No	8	6	1	1
R:R:N240	R:R:R199	12.05	0	No	Yes	9	8	2	1
R:R:R199	R:R:Y241	13.38	1	Yes	No	8	7	1	2
R:R:K206	R:R:V203	6.07	1	Yes	No	6	7	1	2
R:R:D207	R:R:K206	11.06	1	Yes	Yes	7	6	2	1
R:R:K206	R:R:L210	4.23	1	Yes	Yes	6	7	1	2
R:R:K206	R:R:M230	4.32	1	Yes	No	6	6	1	2
R:R:F233	R:R:K206	16.13	0	Yes	Yes	6	6	1	1
R:R:D207	R:R:Y211	6.9	1	Yes	Yes	7	4	2	1
R:R:L210	R:R:Y211	10.55	1	Yes	Yes	7	4	2	1
R:R:L210	R:R:M230	8.48	1	Yes	No	7	6	2	2
R:R:D298	R:R:L210	10.86	0	No	Yes	6	7	1	2
R:R:F233	R:R:H234	7.92	0	Yes	Yes	6	7	1	2
R:R:H234	R:R:W306	6.35	1	Yes	Yes	7	5	2	1
R:R:H234	R:R:I309	11.93	1	Yes	No	7	7	2	2
R:R:V238	R:R:V313	4.81	0	No	No	6	7	2	1
R:R:V313	R:R:Y241	11.36	0	No	No	7	7	1	2
R:R:D298	R:R:M299	4.16	0	No	No	6	5	1	1
R:R:D301	R:R:M299	4.16	0	No	No	4	5	1	1
R:R:N300	R:R:W306	15.82	0	No	Yes	6	5	2	1
R:R:I309	R:R:W306	5.87	1	No	Yes	7	5	2	1
R:R:K310	R:R:W306	9.28	0	Yes	Yes	6	5	2	1
R:R:F369	R:R:R381	13.9	2	No	No	6	7	2	1
R:R:E385	R:R:F369	8.16	2	No	No	8	6	2	2
R:R:E385	R:R:R381	9.3	2	No	No	8	7	2	1
R:R:A200	R:R:Y161	4	0	No	Yes	8	7	2	1
R:R:F233	R:R:S202	3.96	0	Yes	No	6	6	1	2
L:L:Y10	R:R:L151	3.52	1	Yes	No	0	2	0	1
R:R:F204	R:R:Y161	3.09	0	No	Yes	7	7	2	1
R:R:E213	R:R:K154	2.7	0	No	Yes	3	5	2	1
R:R:S164	R:R:Y161	2.54	0	No	Yes	9	7	2	1
R:R:G387	R:R:L386	1.71	0	No	No	5	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6P9Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.14
Number of Linked Nodes	265
Number of Links	295
Number of Hubs	39
Number of Links mediated by Hubs	147
Number of Communities	8
Number of Nodes involved in Communities	57
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	43823
Length Of Smallest Path	3
Average Path Length	12.8295
Length of Longest Path	31
Minimum Path Strength	1.485
Average Path Strength	7.46579
Maximum Path Strength	18.935
Minimum Path Correlation	0.7
Average Path Correlation	0.94335
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	62.1339
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.7144
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • signaling receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • multicellular organismal process • positive regulation of biological process • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of chemokine (C-C motif) ligand 5 production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell cycle • cell cycle • regulation of cell cycle • cell-cell signaling • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of G protein-coupled receptor signaling pathway • regulation of localization • localization • regulation of protein localization • macromolecule localization • intracellular protein localization • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • export from cell • establishment of localization • regulation of secretion • peptide transport • positive regulation of growth hormone secretion • positive regulation of transport • peptide hormone secretion • hormone transport • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • establishment of protein localization • protein localization to extracellular region • establishment of protein localization to extracellular region • protein secretion • protein transport • insulin secretion • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • cellular component organization or biogenesis • system development • somatodendritic compartment • cell body • perikaryon • neuronal cell body • cell projection • neuron projection • plasma membrane bounded cell projection • small GTPase binding • enzyme binding • GTPase binding • molecular transducer activity • signaling receptor activity • adenylate cyclase binding • vasoactive intestinal polypeptide receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • response to xenobiotic stimulus • spermatogenesis • sexual reproduction • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • response to stress • multicellular organismal response to stress • response to ethanol • cell surface receptor signaling pathway • cAMP/PKA signal transduction • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of monoatomic ion transport • transmembrane transport • positive regulation of calcium ion transport into cytosol • regulation of transmembrane transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • calcium ion transport into cytosol • positive regulation of cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of small GTPase mediated signal transduction • development of primary sexual characteristics • sex differentiation • female sex differentiation • development of primary female sexual characteristics • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • regulation of small molecule metabolic process • polyol biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • response to estradiol • negative regulation of response to reactive oxygen species • negative regulation of response to stimulus • response to reactive oxygen species • response to oxidative stress • regulation of response to reactive oxygen species • regulation of response to stress • regulation of response to oxidative stress • negative regulation of response to oxidative stress • cell surface • membrane microdomain • membrane raft • plasma membrane raft • plasma membrane region • caveola • receptor complex • endosome • intracellular vesicle • cytoplasmic vesicle • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41586
Sequence	>6P9Y_nogp_Chain_R Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F R K L H C T R N F I H M N L F V S F M L R A I S V F I K D W I L Y A E I S T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E T F F P E R R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D D T G C W D M N D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L Q S P D S I Y L R L A R S T L L L I P L F G I H Y T V F A F S P E N V S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E V Q A E I K R K W R S W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6P9Y	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9Y (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	8E3X	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3X (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	6LPB	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ1	3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6LPB (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8

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