psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:H1	5.04	Yes	Yes	1	0	0
2	L:L:G4	L:L:H1	4.77	No	Yes	0	0	0
3	L:L:H1	R:R:H234	7.17	Yes	Yes	1	0	7
4	L:L:H1	R:R:V237	16.61	Yes	Yes	1	0	6
5	L:L:H1	R:R:Y241	4.36	Yes	Yes	1	0	7
6	L:L:S2	R:R:E385	7.19	No	Yes	0	0	8
7	L:L:D3	R:R:Y161	5.75	Yes	Yes	1	0	7
8	L:L:D3	R:R:R199	7.15	Yes	Yes	1	0	8
9	L:L:D3	R:R:F233	5.97	Yes	Yes	1	0	6
10	L:L:D3	R:R:V237	4.38	Yes	Yes	1	0	6
11	L:L:D3	R:R:L386	5.43	Yes	Yes	1	0	8
12	L:L:I5	R:R:E374	12.3	No	No	0	0	4
13	L:L:I5	R:R:R381	5.01	No	No	0	0	7
14	L:L:F6	R:R:Y150	5.16	Yes	Yes	0	0	4
15	L:L:F6	R:R:V153	5.24	Yes	No	0	0	6
16	L:L:F6	R:R:Y157	10.32	Yes	Yes	1	0	8
17	L:L:F6	R:R:L382	4.87	Yes	No	0	0	5
18	L:L:F6	R:R:L386	4.87	Yes	Yes	1	0	8
19	L:L:T7	R:R:K206	12.01	No	Yes	0	0	6
20	L:L:T7	R:R:Y211	3.75	No	Yes	0	0	4
21	L:L:D8	L:L:R12	10.72	No	Yes	0	0	0
22	L:L:D8	R:R:N300	8.08	No	No	0	0	6
23	L:L:S9	R:R:Y150	5.09	No	Yes	0	0	4
24	L:L:S9	R:R:K378	6.12	No	No	0	0	5
25	L:L:R14	L:L:Y10	12.35	No	No	6	0	0
26	L:L:Y10	R:R:Y150	6.95	No	Yes	0	0	4
27	L:L:Y10	R:R:Y211	19.86	No	Yes	6	0	4
28	L:L:S11	R:R:Y211	5.09	No	Yes	0	0	4
29	L:L:S11	R:R:D298	10.31	No	No	0	0	6
30	L:L:Q16	L:L:R12	5.84	No	Yes	0	0	0
31	L:L:R12	R:R:M299	6.2	Yes	No	7	0	5
32	L:L:R12	R:R:D301	4.76	Yes	No	7	0	4
33	L:L:M17	L:L:Y13	17.96	No	Yes	0	0	0
34	L:L:Y13	R:R:Q146	4.51	Yes	No	0	0	1
35	L:L:Y13	R:R:D147	8.05	Yes	No	0	0	1
36	L:L:Y13	R:R:Y150	9.93	Yes	Yes	0	0	4
37	L:L:R14	R:R:Y211	6.17	No	Yes	6	0	4
38	L:L:R14	R:R:Q214	4.67	No	No	0	0	2
39	L:L:K15	R:R:F220	7.44	No	Yes	0	0	3
40	L:L:Q16	R:R:F84	10.54	No	Yes	0	0	5
41	L:L:V19	R:R:F84	5.24	No	Yes	0	0	5
42	L:L:K20	R:R:F84	11.17	No	Yes	2	0	5
43	L:L:K20	R:R:F136	8.69	No	Yes	2	0	3
44	L:L:V26	L:L:Y22	6.31	No	Yes	3	0	0
45	L:L:Y22	R:R:F27	7.22	Yes	Yes	3	0	6
46	L:L:Y22	R:R:K28	7.17	Yes	No	0	0	3
47	L:L:Y22	R:R:Q31	12.4	Yes	Yes	3	0	4
48	L:L:Y22	R:R:N60	4.65	Yes	Yes	3	0	6
49	L:L:L23	R:R:F81	4.87	No	Yes	0	0	6
50	L:L:V26	R:R:N60	8.87	No	Yes	3	0	6
51	R:R:D24	R:R:K28	4.15	No	No	0	3	3
52	R:R:C219	R:R:C25	7.28	No	No	0	4	4
53	R:R:I26	R:R:K29	5.82	No	No	0	5	5
54	R:R:F220	R:R:I26	5.02	Yes	No	0	3	5
55	R:R:F27	R:R:Q31	8.2	Yes	Yes	3	6	4
56	R:R:F27	R:R:L80	6.09	Yes	No	0	6	5
57	R:R:F220	R:R:F27	8.57	Yes	Yes	0	3	6
58	R:R:K28	R:R:W58	4.64	No	Yes	0	3	7
59	R:R:E30	R:R:Q31	10.19	No	Yes	0	7	4
60	R:R:Q31	R:R:W58	7.67	Yes	Yes	0	4	7
61	R:R:K37	R:R:M33	4.32	No	No	0	4	4
62	R:R:C34	R:R:W58	6.53	No	Yes	0	9	7
63	R:R:C34	R:R:C63	7.28	No	No	0	9	9
64	R:R:L35	R:R:Q39	3.99	No	No	0	2	4
65	R:R:I38	R:R:K65	4.36	No	No	0	6	7
66	R:R:N42	R:R:P66	9.77	No	No	0	2	4
67	R:R:L44	R:R:M45	7.07	No	No	0	2	2
68	R:R:F47	R:R:N48	20.54	No	No	0	4	1
69	R:R:H68	R:R:N48	14.03	No	No	0	2	1
70	R:R:D49	R:R:P52	4.83	No	No	0	1	1
71	R:R:C118	R:R:C54	7.28	No	No	4	9	9
72	R:R:C54	R:R:W123	7.84	No	Yes	4	9	9
73	R:R:G56	R:R:P66	4.06	No	No	0	5	4
74	R:R:N60	R:R:W58	10.17	Yes	Yes	0	6	7
75	R:R:D59	R:R:N60	4.04	No	Yes	0	9	6
76	R:R:D59	R:R:I61	12.59	No	No	0	9	4
77	R:R:D59	R:R:W64	4.47	No	Yes	0	9	9
78	R:R:I61	R:R:T62	4.56	No	Yes	0	4	5
79	R:R:T62	R:R:W64	7.28	Yes	Yes	0	5	9
80	R:R:C77	R:R:T62	5.07	No	Yes	0	9	5
81	R:R:V73	R:R:W64	3.68	No	Yes	0	8	9
82	R:R:V75	R:R:W64	13.48	No	Yes	0	6	9
83	R:R:R116	R:R:W64	8	No	Yes	4	9	9
84	R:R:W123	R:R:W64	8.43	Yes	Yes	4	9	9
85	R:R:A67	R:R:E71	4.53	No	No	0	8	3
86	R:R:E71	R:R:H68	11.08	No	No	0	3	2
87	R:R:L74	R:R:S115	4.5	No	No	0	4	5
88	R:R:C77	R:R:F81	8.38	No	Yes	0	9	6
89	R:R:C134	R:R:C77	7.28	No	No	0	9	9
90	R:R:L80	R:R:P78	9.85	No	No	0	5	9
91	R:R:F81	R:R:L80	4.87	Yes	No	0	6	5
92	R:R:D132	R:R:F81	4.78	No	Yes	2	6	6
93	R:R:F136	R:R:F81	6.43	Yes	Yes	2	3	6
94	R:R:N85	R:R:R82	16.87	No	No	0	3	4
95	R:R:D87	R:R:R82	8.34	No	No	0	2	4
96	R:R:F84	R:R:I83	7.54	Yes	No	0	5	4
97	R:R:F136	R:R:F84	6.43	Yes	Yes	2	3	5
98	R:R:R116	R:R:W123	10	No	Yes	4	9	9
99	R:R:P126	R:R:R116	10.09	Yes	No	0	5	9
100	R:R:C118	R:R:W123	3.92	No	Yes	4	9	9
101	R:R:F131	R:R:P126	5.78	No	Yes	0	4	5
102	R:R:F127	R:R:P128	4.33	No	No	0	3	4
103	R:R:P128	R:R:Y130	25.03	No	No	0	4	8
104	R:R:F131	R:R:H129	7.92	No	No	0	4	2
105	R:R:D132	R:R:H129	5.04	No	No	0	6	2
106	R:R:D132	R:R:F136	15.52	No	Yes	2	6	3
107	R:R:D147	R:R:L151	4.07	No	No	0	1	2
108	R:R:V153	R:R:Y149	7.57	No	No	0	6	4
109	R:R:R379	R:R:Y149	23.66	No	No	0	4	4
110	R:R:V383	R:R:Y149	5.05	No	No	0	5	4
111	R:R:K154	R:R:Y157	5.97	No	Yes	1	5	8
112	R:R:D207	R:R:K154	5.53	No	No	1	7	5
113	R:R:Y157	R:R:Y161	7.94	Yes	Yes	1	8	7
114	R:R:D207	R:R:Y157	9.2	No	Yes	1	7	8
115	R:R:L386	R:R:Y157	11.72	Yes	Yes	1	8	8
116	R:R:S390	R:R:Y157	3.82	No	Yes	1	9	8
117	R:R:F391	R:R:G160	9.03	No	No	0	7	9
118	R:R:R199	R:R:Y161	7.2	Yes	Yes	1	8	7
119	R:R:V203	R:R:Y161	10.09	No	Yes	0	7	7
120	R:R:S390	R:R:Y161	16.53	No	Yes	1	9	7
121	R:R:F204	R:R:S162	5.28	No	No	0	7	7
122	R:R:F394	R:R:T163	3.89	No	No	0	5	5
123	R:R:F394	R:R:T167	11.67	No	No	0	5	7
124	R:R:F402	R:R:T167	3.89	No	No	0	8	7
125	R:R:F193	R:R:L168	8.53	No	No	0	8	9
126	R:R:F196	R:R:L168	3.65	Yes	No	0	8	9
127	R:R:M197	R:R:T169	4.52	No	No	0	7	4
128	R:R:M172	R:R:M190	8.66	No	No	0	6	6
129	R:R:I174	R:R:I411	4.42	No	No	0	8	5
130	R:R:L175	R:R:M190	5.65	No	No	0	8	6
131	R:R:F178	R:R:L181	3.65	Yes	No	0	6	9
132	R:R:E410	R:R:F178	10.49	No	Yes	0	8	6
133	R:R:F178	R:R:I411	3.77	Yes	No	0	6	5
134	R:R:F178	R:R:K414	6.2	Yes	No	0	6	5
135	R:R:H182	R:R:R179	12.41	No	No	0	8	8
136	R:R:E410	R:R:K180	12.15	No	No	0	8	7
137	R:R:L181	R:R:V407	5.96	No	No	0	9	9
138	R:R:F187	R:R:H182	7.92	No	No	0	6	8
139	R:R:C183	R:R:R185	5.57	No	Yes	8	8	9
140	R:R:C183	R:R:N186	6.3	No	No	8	8	9
141	R:R:T184	R:R:Y250	8.74	No	No	0	7	8
142	R:R:F266	R:R:T184	3.89	Yes	No	0	6	7
143	R:R:N186	R:R:R185	12.05	No	Yes	8	9	9
144	R:R:H189	R:R:R185	6.77	No	Yes	0	9	9
145	R:R:E406	R:R:R185	4.65	No	Yes	0	9	9
146	R:R:I188	R:R:W243	4.7	No	Yes	0	9	9
147	R:R:E247	R:R:I188	6.83	Yes	No	0	9	9
148	R:R:F266	R:R:I188	5.02	Yes	No	0	6	9
149	R:R:E247	R:R:H189	11.08	Yes	No	0	9	9
150	R:R:H189	R:R:Y400	4.36	No	No	0	9	9
151	R:R:N191	R:R:W243	13.56	No	Yes	0	8	9
152	R:R:F193	R:R:L192	3.65	No	Yes	0	8	9
153	R:R:L192	R:R:S195	4.5	Yes	No	0	9	9
154	R:R:F196	R:R:L192	6.09	Yes	Yes	0	8	9
155	R:R:L192	R:R:L244	4.15	Yes	No	0	9	9
156	R:R:E247	R:R:L192	11.93	Yes	Yes	0	9	9
157	R:R:V194	R:R:W274	4.9	No	No	0	4	8
158	R:R:N240	R:R:S195	7.45	No	No	0	9	9
159	R:R:S195	R:R:W243	4.94	No	Yes	0	9	9
160	R:R:F196	R:R:N240	16.92	Yes	No	0	8	9
161	R:R:F196	R:R:Q392	5.86	Yes	No	0	8	9
162	R:R:F196	R:R:G393	9.03	Yes	No	0	8	9
163	R:R:C236	R:R:L198	6.35	No	No	0	5	7
164	R:R:R199	R:R:V237	9.15	Yes	Yes	1	8	6
165	R:R:N240	R:R:R199	10.85	No	Yes	0	9	8
166	R:R:R199	R:R:Y241	8.23	Yes	Yes	1	8	7
167	R:R:F233	R:R:S202	7.93	Yes	No	0	6	6
168	R:R:C236	R:R:S202	6.89	No	No	0	5	6
169	R:R:F233	R:R:V203	5.24	Yes	No	0	6	7
170	R:R:I205	R:R:V229	4.61	No	No	0	6	6
171	R:R:D207	R:R:K206	4.15	No	Yes	0	7	6
172	R:R:K206	R:R:L210	5.64	Yes	Yes	0	6	7
173	R:R:F233	R:R:K206	17.37	Yes	Yes	0	6	6
174	R:R:I209	R:R:W208	5.87	No	No	0	5	4
175	R:R:E213	R:R:W208	7.63	No	No	0	3	4
176	R:R:L210	R:R:Y211	7.03	Yes	Yes	0	7	4
177	R:R:D298	R:R:L210	8.14	No	Yes	0	6	7
178	R:R:N217	R:R:Q214	7.92	No	No	0	2	2
179	R:R:I221	R:R:N217	5.66	No	No	0	3	2
180	R:R:C226	R:R:C296	7.28	No	No	0	9	9
181	R:R:D293	R:R:K227	9.68	No	No	1	6	7
182	R:R:K227	R:R:W297	26.69	No	Yes	1	7	8
183	R:R:C236	R:R:F232	8.38	No	No	0	5	4
184	R:R:F233	R:R:V237	3.93	Yes	Yes	1	6	6
185	R:R:H234	R:R:W284	8.46	Yes	No	1	7	8
186	R:R:H234	R:R:W306	5.29	Yes	Yes	1	7	5
187	R:R:H234	R:R:I309	9.28	Yes	No	1	7	7
188	R:R:W274	R:R:Y235	4.82	No	No	0	8	9
189	R:R:T278	R:R:Y235	6.24	No	No	0	4	9
190	R:R:V281	R:R:Y235	5.05	No	No	0	7	9
191	R:R:P277	R:R:V238	7.07	No	No	0	9	6
192	R:R:V313	R:R:Y241	11.36	No	Yes	0	7	7
193	R:R:I317	R:R:Y241	4.84	Yes	Yes	1	7	7
194	R:R:Y241	R:R:Y366	18.86	Yes	Yes	1	7	8
195	R:R:F242	R:R:T276	9.08	No	No	0	5	4
196	R:R:I246	R:R:W243	5.87	No	Yes	0	8	9
197	R:R:T270	R:R:W243	6.06	No	Yes	0	5	9
198	R:R:G273	R:R:W243	4.22	No	Yes	0	9	9
199	R:R:W243	R:R:W274	17.81	Yes	No	0	9	8
200	R:R:L244	R:R:Q392	5.32	No	No	0	9	9
201	R:R:F245	R:R:I246	3.77	No	No	0	8	8
202	R:R:F245	R:R:V319	6.55	No	No	0	8	6
203	R:R:I246	R:R:Y269	7.25	No	Yes	0	8	7
204	R:R:E247	R:R:L361	7.95	Yes	No	0	9	9
205	R:R:F362	R:R:G248	6.02	Yes	No	0	9	9
206	R:R:L249	R:R:Y269	12.89	No	Yes	0	6	7
207	R:R:L254	R:R:Y250	15.24	No	No	0	7	8
208	R:R:L251	R:R:L255	8.3	No	No	9	9	8
209	R:R:I327	R:R:L251	5.71	No	No	9	9	9
210	R:R:F252	R:R:V256	11.8	Yes	No	0	7	6
211	R:R:F252	R:R:L323	10.96	Yes	No	0	7	8
212	R:R:F252	R:R:I327	3.77	Yes	No	0	7	9
213	R:R:E257	R:R:T253	5.64	No	No	0	5	7
214	R:R:T253	R:R:Y269	4.99	No	Yes	0	7	7
215	R:R:I327	R:R:L255	4.28	No	No	9	9	8
216	R:R:E257	R:R:Y265	11.22	No	No	0	5	4
217	R:R:E262	R:R:F260	15.16	No	No	0	6	6
218	R:R:E262	R:R:R264	5.82	No	No	0	6	5
219	R:R:E262	R:R:Y265	12.35	No	No	0	6	4
220	R:R:R264	R:R:Y267	8.23	No	No	0	5	3
221	R:R:R264	R:R:W268	18.99	No	No	0	5	3
222	R:R:Y265	R:R:Y269	6.95	No	Yes	0	4	7
223	R:R:F266	R:R:T270	6.49	Yes	No	0	6	5
224	R:R:I271	R:R:Y267	13.3	No	No	0	4	3
225	R:R:I272	R:R:T276	4.56	No	No	0	6	4
226	R:R:P277	R:R:T276	5.25	No	No	0	9	4
227	R:R:C280	R:R:P312	3.77	No	No	0	5	9
228	R:R:R288	R:R:W284	9	Yes	No	1	8	8
229	R:R:W284	R:R:W297	3.75	No	Yes	1	8	8
230	R:R:L287	R:R:L305	4.15	No	No	0	4	2
231	R:R:R288	R:R:W297	21.99	Yes	Yes	1	8	8
232	R:R:D293	R:R:W297	10.05	No	Yes	1	6	8
233	R:R:D298	R:R:M299	4.16	No	No	0	6	5
234	R:R:D301	R:R:M299	8.32	No	No	7	4	5
235	R:R:N300	R:R:W306	25.99	No	Yes	0	6	5
236	R:R:L305	R:R:S302	12.01	No	No	0	2	5
237	R:R:I309	R:R:W306	4.7	No	Yes	1	7	5
238	R:R:K310	R:R:W306	10.44	No	Yes	1	6	5
239	R:R:E374	R:R:W306	8.72	No	Yes	1	4	5
240	R:R:K310	R:R:W307	15.08	No	No	0	6	6
241	R:R:E374	R:R:K310	6.75	No	No	1	4	6
242	R:R:G311	R:R:P312	4.06	No	No	0	4	9
243	R:R:I317	R:R:Y366	4.84	Yes	Yes	1	7	8
244	R:R:F362	R:R:N320	10.87	Yes	No	0	9	9
245	R:R:F321	R:R:I325	7.54	No	No	0	6	5
246	R:R:F321	R:R:T367	6.49	No	No	0	6	6
247	R:R:F324	R:R:I325	3.77	Yes	No	0	9	5
248	R:R:F324	R:R:I328	7.54	Yes	No	0	9	7
249	R:R:F324	R:R:L358	6.09	Yes	No	5	9	9
250	R:R:F324	R:R:F362	5.36	Yes	Yes	5	9	9
251	R:R:F324	R:R:I364	11.3	Yes	No	5	9	6
252	R:R:L331	R:R:L335	4.15	No	No	0	9	8
253	R:R:L351	R:R:V332	4.47	No	No	0	9	6
254	R:R:M340	R:R:S337	7.67	No	No	0	5	7
255	R:R:L349	R:R:S346	6.01	No	No	0	6	6
256	R:R:R350	R:R:R353	14.93	No	No	0	8	8
257	R:R:R350	R:R:S354	3.95	No	No	0	8	9
258	R:R:L357	R:R:L399	5.54	No	No	0	8	8
259	R:R:F362	R:R:L358	3.65	Yes	No	5	9	9
260	R:R:I359	R:R:I364	10.3	No	No	0	8	6
261	R:R:P360	R:R:V395	5.3	No	No	0	9	6
262	R:R:F362	R:R:L361	7.31	Yes	No	0	9	9
263	R:R:L361	R:R:Y400	19.93	No	No	0	9	9
264	R:R:F362	R:R:I364	3.77	Yes	No	5	9	6
265	R:R:H365	R:R:Y366	19.6	Yes	Yes	0	9	8
266	R:R:H365	R:R:Q392	12.36	Yes	No	0	9	9
267	R:R:E385	R:R:Y366	8.98	Yes	Yes	1	8	8
268	R:R:F369	R:R:V368	5.24	Yes	No	0	6	6
269	R:R:F369	R:R:R381	16.03	Yes	No	1	6	7
270	R:R:F369	R:R:F384	5.36	Yes	No	0	6	3
271	R:R:E385	R:R:F369	7	Yes	Yes	1	8	6
272	R:R:N375	R:R:P373	4.89	No	No	10	5	8
273	R:R:P373	R:R:V376	10.6	No	No	10	8	4
274	R:R:N375	R:R:V376	4.43	No	No	10	5	4
275	R:R:E380	R:R:S377	5.75	No	No	0	5	5
276	R:R:E385	R:R:R381	11.63	Yes	No	1	8	7
277	R:R:F394	R:R:V398	5.24	No	No	0	5	5
278	R:R:C401	R:R:F402	4.19	No	No	0	9	8
279	R:R:E406	R:R:N404	17.09	No	No	0	9	9
280	R:R:N404	R:R:V407	5.91	No	No	0	9	9
281	R:R:R416	R:R:W415	7	No	No	0	4	5
282	R:R:G275	R:R:T278	3.64	No	No	0	7	4
283	R:R:I347	R:R:Y348	3.63	No	No	0	7	7
284	R:R:A171	R:R:C401	3.61	No	No	0	9	9
285	R:R:P277	R:R:S239	3.56	No	No	0	9	8
286	R:R:P373	R:R:S372	3.56	No	No	0	8	5
287	R:R:P360	R:R:V396	3.53	No	No	0	9	9
288	R:R:G387	R:R:L156	3.42	No	No	0	5	6
289	R:R:I359	R:R:P360	3.39	No	No	0	8	9
290	R:R:C226	R:R:T223	3.38	No	No	0	9	3
291	R:R:A397	R:R:T167	3.36	No	No	0	9	7
292	R:R:K65	R:R:P66	3.35	No	No	0	7	4
293	R:R:C176	R:R:M172	3.24	No	No	0	4	6
294	R:R:C63	R:R:K37	3.23	No	No	0	9	4
295	R:R:S377	R:R:V376	3.23	No	No	0	5	4
296	R:R:V231	R:R:V281	3.21	No	No	0	6	7
297	R:R:S124	R:R:T119	3.2	No	No	0	6	6
298	R:R:G363	R:R:H365	3.18	No	Yes	0	9	9
299	R:R:T62	R:R:V114	3.17	Yes	No	0	5	6
300	R:R:C296	R:R:L210	3.17	No	Yes	0	9	7
301	R:R:A397	R:R:L168	3.15	No	No	0	9	9
302	R:R:I317	R:R:S316	3.1	Yes	No	0	7	7
303	R:R:M72	R:R:S115	3.07	No	No	0	4	5
304	R:R:I309	R:R:V238	3.07	No	No	0	7	6
305	R:R:K227	R:R:S222	3.06	No	No	0	7	6
306	R:R:M318	R:R:V314	3.04	No	No	0	4	4
307	R:R:I359	R:R:T355	3.04	No	No	0	8	9
308	R:R:L331	R:R:S354	3	No	No	0	9	9
309	L:L:L27	L:L:V26	2.98	No	No	0	0	0
310	R:R:N117	R:R:S124	2.98	No	No	0	4	6
311	R:R:L323	R:R:V319	2.98	No	No	0	8	6
312	R:R:L399	R:R:V395	2.98	No	No	0	8	6
313	R:R:L165	R:R:T169	2.95	No	No	0	7	4
314	R:R:L351	R:R:T355	2.95	No	No	0	9	9
315	R:R:I201	R:R:I205	2.94	No	No	0	4	6
316	R:R:D292	R:R:S302	2.94	No	No	0	5	5
317	R:R:F242	R:R:P312	2.89	No	No	0	5	9
318	R:R:K206	R:R:M230	2.88	Yes	No	0	6	6
319	R:R:I201	R:R:L165	2.85	No	No	0	4	7
320	R:R:G56	R:R:W123	2.81	No	Yes	0	5	9
321	R:R:W415	R:R:W418	2.81	No	No	0	5	4
322	R:R:M72	R:R:N117	2.8	No	No	0	4	4
323	R:R:L175	R:R:L181	2.77	No	No	0	8	9
324	R:R:I347	R:R:Q336	2.74	No	No	0	7	7
325	R:R:E225	R:R:I209	2.73	No	No	0	5	5
326	R:R:D293	R:R:L289	2.71	No	No	0	6	3
327	R:R:D137	R:R:N85	2.69	No	No	0	1	3
328	R:R:A200	R:R:Y161	2.67	No	Yes	0	8	7
329	R:R:F369	R:R:S372	2.64	Yes	No	0	6	5
330	R:R:E213	R:R:N217	2.63	No	No	0	3	2
331	R:R:D137	R:R:E138	2.6	No	No	0	1	1
332	R:R:F402	R:R:T170	2.59	No	No	0	8	5
333	R:R:A212	R:R:W208	2.59	No	No	0	4	4
334	R:R:S164	R:R:Y161	2.54	No	Yes	0	9	7
335	R:R:T158	R:R:Y157	2.5	No	Yes	0	7	8
336	R:R:L44	R:R:R40	2.43	No	No	0	2	5
337	R:R:L305	R:R:R288	2.43	No	Yes	0	2	8
338	R:R:T303	R:R:W307	2.43	No	No	0	6	6
339	R:R:L357	R:R:R353	2.43	No	No	0	8	8
340	R:R:E344	R:R:R350	2.33	No	No	0	7	8
341	R:R:E410	R:R:R413	2.33	No	No	0	8	7
342	R:R:L35	R:R:W58	2.28	No	Yes	0	2	7
343	R:R:F187	R:R:R263	2.14	No	No	0	6	4
344	R:R:F187	R:R:F266	2.14	No	Yes	0	6	6
345	R:R:G341	R:R:G342	2.11	No	No	0	5	5
346	R:R:F204	R:R:Y161	2.06	No	Yes	0	7	7
347	R:R:G53	R:R:P55	2.03	No	Yes	0	1	4
348	R:R:P52	R:R:P55	1.95	No	Yes	0	1	4
349	R:R:C54	R:R:P55	1.88	No	Yes	0	9	4
350	R:R:G160	R:R:S390	1.86	No	No	0	9	9
351	R:R:G295	R:R:S222	1.86	No	No	0	4	6
352	R:R:G341	R:R:S337	1.86	No	No	0	5	7
353	R:R:G53	R:R:V69	1.84	No	No	0	1	6
354	R:R:G70	R:R:V69	1.84	No	No	0	7	6
355	R:R:G326	R:R:V329	1.84	No	No	0	8	8
356	R:R:G122	R:R:T119	1.82	No	No	0	9	6
357	R:R:P52	R:R:S51	1.78	No	No	0	1	5
358	R:R:P338	R:R:S337	1.78	No	No	0	6	7
359	R:R:G342	R:R:I347	1.76	No	No	0	5	7
360	R:R:G387	R:R:L386	1.71	No	Yes	0	5	8
361	R:R:A67	R:R:V73	1.7	No	No	0	8	8
362	R:R:A285	R:R:V231	1.7	No	No	0	5	6
363	R:R:G342	R:R:N343	1.7	No	No	0	5	6
364	R:R:M57	R:R:P55	1.68	No	Yes	0	6	4
365	R:R:D121	R:R:G122	1.68	No	No	0	4	9
366	R:R:E406	R:R:G405	1.64	No	No	0	9	5
367	R:R:G405	R:R:Q408	1.64	No	No	0	5	7
368	R:R:N85	R:R:P86	1.63	No	No	0	3	2
369	R:R:S152	R:R:V153	1.62	No	No	0	4	6
370	R:R:A370	R:R:I317	1.62	No	Yes	0	6	7
371	R:R:A32	R:R:K29	1.61	No	No	0	2	5
372	R:R:A370	R:R:M318	1.61	No	No	0	6	4
373	R:R:D339	R:R:P338	1.61	No	No	0	7	6
374	R:R:V279	R:R:V283	1.6	No	No	0	4	4
375	R:R:V283	R:R:V308	1.6	No	No	0	4	8
376	R:R:T163	R:R:V159	1.59	No	No	0	5	6
377	R:R:T170	R:R:V166	1.59	No	No	0	5	4
378	R:R:T169	R:R:V173	1.59	No	No	0	4	1
379	R:R:T282	R:R:V279	1.59	No	No	0	3	4
380	R:R:T286	R:R:V283	1.59	No	No	0	4	4
381	R:R:G389	R:R:H365	1.59	No	Yes	0	7	9
382	R:R:A200	R:R:L165	1.58	No	No	0	8	7
383	R:R:E125	R:R:P126	1.57	No	Yes	0	4	5
384	R:R:T278	R:R:T282	1.57	No	No	0	4	3
385	R:R:I330	R:R:V256	1.54	No	No	0	8	6
386	R:R:F136	R:R:G135	1.51	Yes	No	0	3	3
387	R:R:F252	R:R:G326	1.51	Yes	No	0	7	8
388	R:R:L403	R:R:V398	1.49	No	No	0	7	5
389	R:R:D49	R:R:S50	1.47	No	No	0	1	3
390	R:R:I330	R:R:K334	1.45	No	No	0	8	9
391	R:R:E213	R:R:S216	1.44	No	No	0	3	2
392	R:R:F260	R:R:P261	1.44	No	No	0	6	7
393	R:R:E344	R:R:S346	1.44	No	No	0	7	6
394	R:R:E120	R:R:T119	1.41	No	No	0	1	6
395	R:R:C25	R:R:F220	1.4	No	Yes	0	4	3
396	R:R:P126	R:R:Y130	1.39	Yes	No	0	5	8
397	R:R:R177	R:R:V173	1.31	No	No	0	3	1
398	R:R:R288	R:R:T294	1.29	Yes	No	0	8	3
399	R:R:E36	R:R:Q39	1.27	No	No	0	4	4
400	R:R:S152	R:R:Y148	1.27	No	No	0	4	1
401	R:R:F384	R:R:L388	1.22	No	No	0	3	7
402	R:R:D292	R:R:F291	1.19	No	No	0	5	3
403	R:R:E138	R:R:F84	1.17	No	Yes	0	1	5
404	R:R:E36	R:R:R40	1.16	No	No	0	4	5
405	R:R:E79	R:R:R82	1.16	No	No	0	2	4
406	R:R:K414	R:R:W418	1.16	No	No	0	5	4
407	R:R:F291	R:R:Y290	1.03	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	7.59	5	1	0
2	L:L:D3	5.62	6	1	0
3	L:L:F6	6.092	5	1	0
4	L:L:R12	6.88	4	7	0
5	L:L:Y13	10.1125	4	0	0
6	L:L:Y22	7.55	5	3	0
7	R:R:F27	7.52	4	3	6
8	R:R:Q31	9.615	4	3	4
9	R:R:P55	1.885	4	0	4
10	R:R:W58	6.258	5	0	7
11	R:R:N60	6.9325	4	3	6
12	R:R:T62	5.02	4	0	5
13	R:R:W64	7.55667	6	4	9
14	R:R:F81	5.866	5	2	6
15	R:R:F84	7.015	6	2	5
16	R:R:W123	6.6	5	4	9
17	R:R:P126	4.7075	4	0	5
18	R:R:F136	7.716	5	2	3
19	R:R:Y150	6.7825	4	0	4
20	R:R:Y157	7.35286	7	1	8
21	R:R:Y161	6.8475	8	1	7
22	R:R:F178	6.0275	4	0	6
23	R:R:R185	7.26	4	8	9
24	R:R:L192	6.064	5	0	9
25	R:R:F196	8.31	5	0	8
26	R:R:R199	8.516	5	1	8
27	R:R:K206	8.41	5	0	6
28	R:R:L210	5.995	4	0	7
29	R:R:Y211	8.38	5	6	4
30	R:R:F220	5.6075	4	0	3
31	R:R:F233	8.088	5	1	6
32	R:R:H234	7.55	4	1	7
33	R:R:V237	8.5175	4	1	6
34	R:R:Y241	9.53	5	1	7
35	R:R:W243	8.16572	7	0	9
36	R:R:E247	9.4475	4	0	9
37	R:R:F252	7.01	4	0	7
38	R:R:F266	4.385	4	0	6
39	R:R:Y269	8.02	4	0	7
40	R:R:R288	8.6775	4	1	8
41	R:R:W297	15.62	4	1	8
42	R:R:W306	11.028	5	1	5
43	R:R:I317	3.6	4	1	7
44	R:R:F324	6.812	5	5	9
45	R:R:F362	6.16333	6	5	9
46	R:R:H365	9.1825	4	0	9
47	R:R:Y366	13.07	4	1	8
48	R:R:F369	7.254	5	1	6
49	R:R:E385	8.7	4	1	8
50	R:R:L386	5.9325	4	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:H1	21.8051	5.04	Yes	Yes	1	0	0
2	L:L:H1	R:R:H234	56.3738	7.17	Yes	Yes	1	0	7
3	L:L:H1	R:R:Y241	20.3649	4.36	Yes	Yes	1	0	7
4	L:L:D3	R:R:R199	40.711	7.15	Yes	Yes	1	0	8
5	R:R:R199	R:R:Y241	21.5328	8.23	Yes	Yes	1	8	7
6	R:R:H234	R:R:W306	43.8335	5.29	Yes	Yes	1	7	5
7	L:L:D3	R:R:F233	21.6484	5.97	Yes	Yes	1	0	6
8	R:R:F233	R:R:K206	41.2722	17.37	Yes	Yes	0	6	6
9	R:R:K206	R:R:L210	37.4196	5.64	Yes	Yes	0	6	7
10	R:R:N300	R:R:W306	43.0144	25.99	No	Yes	0	6	5
11	L:L:D8	R:R:N300	42.5969	8.08	No	No	0	0	6
12	L:L:D8	L:L:R12	42.2105	10.72	No	Yes	0	0	0
13	R:R:D298	R:R:L210	32.8728	8.14	No	Yes	0	6	7
14	R:R:D298	R:R:M299	34.1526	4.16	No	No	0	6	5
15	L:L:R12	R:R:M299	33.4607	6.2	Yes	No	7	0	5
16	L:L:Q16	L:L:R12	74.3234	5.84	No	Yes	0	0	0
17	L:L:R14	R:R:Q214	12.2594	4.67	No	No	0	0	2
18	L:L:Q16	R:R:F84	73.5311	10.54	No	Yes	0	0	5
19	R:R:F136	R:R:F84	64.6657	6.43	Yes	Yes	2	3	5
20	R:R:F136	R:R:F81	55.3178	6.43	Yes	Yes	2	3	6
21	R:R:F81	R:R:L80	25.283	4.87	Yes	No	0	6	5
22	R:R:F27	R:R:L80	23.535	6.09	Yes	No	0	6	5
23	R:R:F27	R:R:Q31	11.3919	8.2	Yes	Yes	3	6	4
24	R:R:C77	R:R:F81	28.6994	8.38	No	Yes	0	9	6
25	R:R:C77	R:R:T62	27.015	5.07	No	Yes	0	9	5
26	R:R:T62	R:R:W64	23.6051	7.28	Yes	Yes	0	5	9
27	R:R:W123	R:R:W64	15.3197	8.43	Yes	Yes	4	9	9
28	R:R:N240	R:R:R199	100	10.85	No	Yes	0	9	8
29	R:R:F196	R:R:N240	38.5962	16.92	Yes	No	0	8	9
30	R:R:N240	R:R:S195	62.228	7.45	No	No	0	9	9
31	R:R:L192	R:R:S195	30.7839	4.5	Yes	No	0	9	9
32	R:R:F196	R:R:L192	31.9778	6.09	Yes	Yes	0	8	9
33	R:R:E247	R:R:L192	60.4186	11.93	Yes	Yes	0	9	9
34	R:R:E247	R:R:H189	28.7174	11.08	Yes	No	0	9	9
35	R:R:H189	R:R:R185	26.9363	6.77	No	Yes	0	9	9
36	R:R:E406	R:R:R185	23.465	4.65	No	Yes	0	9	9
37	R:R:E406	R:R:N404	19.9893	17.09	No	No	0	9	9
38	R:R:N404	R:R:V407	18.825	5.91	No	No	0	9	9
39	R:R:L181	R:R:V407	17.6592	5.96	No	No	0	9	9
40	R:R:F178	R:R:L181	11.8087	3.65	Yes	No	0	6	9
41	R:R:S195	R:R:W243	33.4369	4.94	No	Yes	0	9	9
42	R:R:E247	R:R:L361	33.2368	7.95	Yes	No	0	9	9
43	R:R:N217	R:R:Q214	10.9029	7.92	No	No	0	2	2
44	R:R:I246	R:R:W243	16.4689	5.87	No	Yes	0	8	9
45	R:R:F362	R:R:L361	31.4672	7.31	Yes	No	0	9	9
46	R:R:F362	R:R:I364	21.0272	3.77	Yes	No	5	9	6
47	R:R:I359	R:R:I364	19.9445	10.3	No	No	0	8	6
48	R:R:I359	R:R:P360	15.2872	3.39	No	No	0	8	9
49	R:R:P360	R:R:V395	12.9499	5.3	No	No	0	9	6
50	R:R:L399	R:R:V395	11.7791	2.98	No	No	0	8	6
51	R:R:L357	R:R:L399	10.6068	5.54	No	No	0	8	8
52	L:L:H1	R:R:V237	18.8625	16.61	Yes	Yes	1	0	6
53	R:R:R199	R:R:V237	35.936	9.15	Yes	Yes	1	8	6
54	R:R:F233	R:R:V237	20.3281	3.93	Yes	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:H234	7.17	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:V237	16.61	1	Yes	Yes	0	6	0	1
L:L:H1	R:R:Y241	4.36	1	Yes	Yes	0	7	0	1
L:L:S2	R:R:E385	7.19	0	No	Yes	0	8	0	1
L:L:D3	R:R:Y161	5.75	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:R199	7.15	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:F233	5.97	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:V237	4.38	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:L386	5.43	1	Yes	Yes	0	8	0	1
L:L:I5	R:R:E374	12.3	0	No	No	0	4	0	1
L:L:I5	R:R:R381	5.01	0	No	No	0	7	0	1
L:L:F6	R:R:Y150	5.16	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:V153	5.24	1	Yes	No	0	6	0	1
L:L:F6	R:R:Y157	10.32	1	Yes	Yes	0	8	0	1
L:L:F6	R:R:L382	4.87	1	Yes	No	0	5	0	1
L:L:F6	R:R:L386	4.87	1	Yes	Yes	0	8	0	1
L:L:T7	R:R:K206	12.01	0	No	Yes	0	6	0	1
L:L:T7	R:R:Y211	3.75	0	No	Yes	0	4	0	1
L:L:D8	R:R:N300	8.08	0	No	No	0	6	0	1
L:L:S9	R:R:Y150	5.09	0	No	Yes	0	4	0	1
L:L:S9	R:R:K378	6.12	0	No	No	0	5	0	1
L:L:Y10	R:R:Y150	6.95	6	No	Yes	0	4	0	1
L:L:Y10	R:R:Y211	19.86	6	No	Yes	0	4	0	1
L:L:S11	R:R:Y211	5.09	0	No	Yes	0	4	0	1
L:L:S11	R:R:D298	10.31	0	No	No	0	6	0	1
L:L:R12	R:R:M299	6.2	7	Yes	No	0	5	0	1
L:L:R12	R:R:D301	4.76	7	Yes	No	0	4	0	1
L:L:Y13	R:R:Q146	4.51	0	Yes	No	0	1	0	1
L:L:Y13	R:R:D147	8.05	0	Yes	No	0	1	0	1
L:L:Y13	R:R:Y150	9.93	0	Yes	Yes	0	4	0	1
L:L:R14	R:R:Y211	6.17	6	No	Yes	0	4	0	1
L:L:R14	R:R:Q214	4.67	6	No	No	0	2	0	1
L:L:K15	R:R:F220	7.44	0	No	Yes	0	3	0	1
L:L:Q16	R:R:F84	10.54	0	No	Yes	0	5	0	1
L:L:V19	R:R:F84	5.24	0	No	Yes	0	5	0	1
L:L:K20	R:R:F84	11.17	2	No	Yes	0	5	0	1
L:L:K20	R:R:F136	8.69	2	No	Yes	0	3	0	1
L:L:Y22	R:R:F27	7.22	3	Yes	Yes	0	6	0	1
L:L:Y22	R:R:K28	7.17	3	Yes	No	0	3	0	1
L:L:Y22	R:R:Q31	12.4	3	Yes	Yes	0	4	0	1
L:L:Y22	R:R:N60	4.65	3	Yes	Yes	0	6	0	1
L:L:L23	R:R:F81	4.87	0	No	Yes	0	6	0	1
L:L:V26	R:R:N60	8.87	3	No	Yes	0	6	0	1
R:R:D24	R:R:K28	4.15	0	No	No	3	3	2	1
R:R:F220	R:R:I26	5.02	0	Yes	No	3	5	1	2
R:R:F27	R:R:Q31	8.2	3	Yes	Yes	6	4	1	1
R:R:F27	R:R:L80	6.09	3	Yes	No	6	5	1	2
R:R:F220	R:R:F27	8.57	0	Yes	Yes	3	6	1	1
R:R:K28	R:R:W58	4.64	0	No	Yes	3	7	1	2
R:R:E30	R:R:Q31	10.19	0	No	Yes	7	4	2	1
R:R:Q31	R:R:W58	7.67	3	Yes	Yes	4	7	1	2
R:R:N60	R:R:W58	10.17	3	Yes	Yes	6	7	1	2
R:R:D59	R:R:N60	4.04	0	No	Yes	9	6	2	1
R:R:C77	R:R:F81	8.38	0	No	Yes	9	6	2	1
R:R:F81	R:R:L80	4.87	2	Yes	No	6	5	1	2
R:R:D132	R:R:F81	4.78	2	No	Yes	6	6	2	1
R:R:F136	R:R:F81	6.43	2	Yes	Yes	3	6	1	1
R:R:F84	R:R:I83	7.54	2	Yes	No	5	4	1	2
R:R:F136	R:R:F84	6.43	2	Yes	Yes	3	5	1	1
R:R:D132	R:R:F136	15.52	2	No	Yes	6	3	2	1
R:R:D147	R:R:L151	4.07	0	No	No	1	2	1	2
R:R:V153	R:R:Y149	7.57	0	No	No	6	4	1	2
R:R:K154	R:R:Y157	5.97	1	No	Yes	5	8	2	1
R:R:D207	R:R:K154	5.53	1	No	No	7	5	2	2
R:R:Y157	R:R:Y161	7.94	1	Yes	Yes	8	7	1	1
R:R:D207	R:R:Y157	9.2	1	No	Yes	7	8	2	1
R:R:L386	R:R:Y157	11.72	1	Yes	Yes	8	8	1	1
R:R:S390	R:R:Y157	3.82	1	No	Yes	9	8	2	1
R:R:R199	R:R:Y161	7.2	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y161	10.09	0	No	Yes	7	7	2	1
R:R:S390	R:R:Y161	16.53	1	No	Yes	9	7	2	1
R:R:R199	R:R:V237	9.15	1	Yes	Yes	8	6	1	1
R:R:N240	R:R:R199	10.85	0	No	Yes	9	8	2	1
R:R:R199	R:R:Y241	8.23	1	Yes	Yes	8	7	1	1
R:R:F233	R:R:S202	7.93	1	Yes	No	6	6	1	2
R:R:F233	R:R:V203	5.24	1	Yes	No	6	7	1	2
R:R:D207	R:R:K206	4.15	1	No	Yes	7	6	2	1
R:R:K206	R:R:L210	5.64	0	Yes	Yes	6	7	1	2
R:R:F233	R:R:K206	17.37	1	Yes	Yes	6	6	1	1
R:R:L210	R:R:Y211	7.03	0	Yes	Yes	7	4	2	1
R:R:D298	R:R:L210	8.14	0	No	Yes	6	7	1	2
R:R:N217	R:R:Q214	7.92	0	No	No	2	2	2	1
R:R:F233	R:R:V237	3.93	1	Yes	Yes	6	6	1	1
R:R:H234	R:R:W284	8.46	1	Yes	No	7	8	1	2
R:R:H234	R:R:W306	5.29	1	Yes	Yes	7	5	1	2
R:R:H234	R:R:I309	9.28	1	Yes	No	7	7	1	2
R:R:V313	R:R:Y241	11.36	0	No	Yes	7	7	2	1
R:R:I317	R:R:Y241	4.84	1	Yes	Yes	7	7	2	1
R:R:Y241	R:R:Y366	18.86	1	Yes	Yes	7	8	1	2
R:R:D298	R:R:M299	4.16	0	No	No	6	5	1	1
R:R:D301	R:R:M299	8.32	7	No	No	4	5	1	1
R:R:N300	R:R:W306	25.99	0	No	Yes	6	5	1	2
R:R:I309	R:R:W306	4.7	1	No	Yes	7	5	2	2
R:R:K310	R:R:W306	10.44	1	No	Yes	6	5	2	2
R:R:E374	R:R:W306	8.72	1	No	Yes	4	5	1	2
R:R:E374	R:R:K310	6.75	1	No	No	4	6	1	2
R:R:I317	R:R:Y366	4.84	1	Yes	Yes	7	8	2	2
R:R:E385	R:R:Y366	8.98	1	Yes	Yes	8	8	1	2
R:R:F369	R:R:R381	16.03	1	Yes	No	6	7	2	1
R:R:E385	R:R:F369	7	1	Yes	Yes	8	6	1	2
R:R:E385	R:R:R381	11.63	1	Yes	No	8	7	1	1
R:R:K206	R:R:M230	2.88	0	Yes	No	6	6	1	2
R:R:A200	R:R:Y161	2.67	0	No	Yes	8	7	2	1
R:R:S164	R:R:Y161	2.54	0	No	Yes	9	7	2	1
R:R:T158	R:R:Y157	2.5	0	No	Yes	7	8	2	1
R:R:F204	R:R:Y161	2.06	0	No	Yes	7	7	2	1
R:R:G387	R:R:L386	1.71	0	No	Yes	5	8	2	1
R:R:S152	R:R:V153	1.62	0	No	No	4	6	2	1
R:R:F136	R:R:G135	1.51	2	Yes	No	3	3	1	2
R:R:C25	R:R:F220	1.4	0	No	Yes	4	3	2	1
R:R:E138	R:R:F84	1.17	0	No	Yes	1	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E3X_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	362
Number of Links	407
Number of Hubs	50
Number of Links mediated by Hubs	191
Number of Communities	10
Number of Nodes involved in Communities	62
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	194401
Length Of Smallest Path	3
Average Path Length	18.8324
Length of Longest Path	39
Minimum Path Strength	1.11
Average Path Strength	7.66674
Maximum Path Strength	24.34
Minimum Path Correlation	0.7
Average Path Correlation	0.957802
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	55.5206
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.5778
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• small GTPase binding • protein binding • binding • enzyme binding • GTPase binding • molecular transducer activity • signaling receptor activity • adenylate cyclase binding • vasoactive intestinal polypeptide receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • response to stimulus • response to chemical • response to xenobiotic stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • cellular process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal process • response to stress • multicellular organismal response to stress • response to alcohol • response to oxygen-containing compound • response to ethanol • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • intracellular signal transduction • cAMP/PKA signal transduction • intracellular signaling cassette • regulation of localization • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • transport • monoatomic ion transmembrane transport • positive regulation of biological process • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • regulation of calcium ion transmembrane transport • localization • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • regulation of biological quality • monoatomic cation transport • regulation of metal ion transport • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • establishment of localization • transmembrane transport • positive regulation of calcium ion transport into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • calcium ion transport into cytosol • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of small GTPase mediated signal transduction • multicellular organism development • development of primary sexual characteristics • sex differentiation • anatomical structure development • female sex differentiation • development of primary female sexual characteristics • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • response to lipid • response to estradiol • negative regulation of response to reactive oxygen species • negative regulation of response to stimulus • negative regulation of biological process • response to reactive oxygen species • response to oxidative stress • regulation of response to reactive oxygen species • regulation of response to stress • regulation of response to oxidative stress • negative regulation of response to oxidative stress • cell surface • cellular anatomical structure • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • membrane • plasma membrane • plasma membrane region • caveola • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle
Gene Ontology	Cellular Component	• cell surface • cellular anatomical structure • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • membrane • plasma membrane • plasma membrane region • caveola • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • protein-containing complex • receptor complex • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • cytoplasm • vesicle • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction • cell junction • protein binding • binding • signaling receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • multicellular organismal process • positive regulation of biological process • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of chemokine (C-C motif) ligand 5 production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell cycle • cell cycle • regulation of cell cycle • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell-cell signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of G protein-coupled receptor signaling pathway • regulation of localization • localization • regulation of protein localization • macromolecule localization • intracellular protein localization • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • export from cell • establishment of localization • regulation of secretion • peptide transport • positive regulation of growth hormone secretion • positive regulation of transport • peptide hormone secretion • hormone transport • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • establishment of protein localization • protein localization to extracellular region • establishment of protein localization to extracellular region • protein secretion • protein transport • insulin secretion • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • cellular component organization or biogenesis • system development • somatodendritic compartment • cell body • perikaryon • neuronal cell body • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular region • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • regulation of establishment of protein localization • regulation of protein transport • regulation of protein secretion • regulation of insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41586
Sequence	>8E3X_nogp_Chain_R D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D V S R N C T E D G W S E P F P H Y F D A C G F D E Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F R K L H C T R N F I H M N L F V S F M L R A I S V F I K D W I L Y A E Q D S N H C F I S T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E T F F P E R R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D D T G C W D M N D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L Q S P D M G G N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S P E N V S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E V Q A E I K R K W R S W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6P9Y	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9Y (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	8E3X	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3X (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	6LPB	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ1	3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6LPB (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8

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