psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L25	R:R:V28	4.47	No	No	0	3	4
2	R:R:P29	R:R:V28	5.3	No	No	0	5	4
3	R:R:D268	R:R:P29	8.05	No	No	0	5	5
4	R:R:F90	R:R:V30	11.8	No	No	0	4	4
5	R:R:M272	R:R:Y32	11.97	Yes	No	0	6	5
6	R:R:L276	R:R:Y32	5.86	No	No	0	6	5
7	R:R:L36	R:R:Y33	3.52	No	Yes	0	7	7
8	R:R:V81	R:R:Y33	7.57	No	Yes	0	7	7
9	R:R:F85	R:R:Y33	31.98	Yes	Yes	0	5	7
10	R:R:M272	R:R:Y33	7.18	Yes	Yes	0	6	7
11	R:R:L275	R:R:Y33	4.69	No	Yes	0	6	7
12	R:R:L35	R:R:S34	4.5	No	No	0	4	5
13	R:R:L37	R:R:L41	5.54	Yes	No	4	7	7
14	R:R:L37	R:R:L77	4.15	Yes	No	4	7	7
15	R:R:L37	R:R:V81	10.43	Yes	No	0	7	7
16	R:R:F82	R:R:L37	3.65	No	Yes	0	7	7
17	R:R:F283	R:R:L39	3.65	No	No	0	6	6
18	R:R:L41	R:R:L77	6.92	No	No	4	7	7
19	R:R:A43	R:R:F282	8.32	No	Yes	0	8	9
20	R:R:D73	R:R:N44	8.08	Yes	No	0	9	9
21	R:R:F282	R:R:N44	4.83	Yes	No	0	9	9
22	R:R:I50	R:R:L46	7.14	Yes	No	0	8	6
23	R:R:F282	R:R:T47	3.89	Yes	No	0	9	8
24	R:R:F292	R:R:T47	5.19	Yes	No	0	9	8
25	R:R:L67	R:R:V48	4.47	No	No	0	6	7
26	R:R:I50	R:R:T299	12.16	Yes	No	0	8	5
27	R:R:L51	R:R:Y63	4.69	No	Yes	0	7	8
28	R:R:L51	R:R:L67	4.15	No	No	0	7	6
29	R:R:F292	R:R:L51	4.87	Yes	No	0	9	7
30	R:R:L54	R:R:R58	7.29	No	No	0	5	6
31	R:R:A56	R:R:Y63	4	No	Yes	0	7	8
32	R:R:N64	R:R:R57	4.82	No	No	0	5	7
33	R:R:K60	R:R:Y63	25.08	No	Yes	0	7	8
34	R:R:D125	R:R:S61	5.89	Yes	Yes	2	9	7
35	R:R:S61	R:R:Y136	5.09	Yes	Yes	2	7	7
36	R:R:S140	R:R:S61	4.89	No	Yes	2	8	7
37	R:R:S61	R:R:T145	6.4	Yes	No	0	7	8
38	R:R:M295	R:R:Y63	3.59	No	Yes	0	6	8
39	R:R:N64	R:R:T145	4.39	No	No	0	5	8
40	R:R:P121	R:R:Y65	6.95	No	Yes	2	7	8
41	R:R:D125	R:R:Y65	6.9	Yes	Yes	2	9	8
42	R:R:T145	R:R:Y65	9.99	No	Yes	0	8	8
43	R:R:V148	R:R:Y65	6.31	No	Yes	2	6	8
44	R:R:I149	R:R:Y65	3.63	No	Yes	0	7	8
45	R:R:L122	R:R:L66	4.15	No	No	0	8	9
46	R:R:A68	R:R:I118	4.87	No	No	0	8	7
47	R:R:A68	R:R:I149	6.5	No	No	0	8	7
48	R:R:D73	R:R:L69	5.43	Yes	No	0	9	9
49	R:R:L69	R:R:Y285	3.52	No	Yes	0	9	9
50	R:R:D73	R:R:S115	4.42	Yes	No	5	9	9
51	R:R:D73	R:R:T278	5.78	Yes	No	5	9	8
52	R:R:F79	R:R:L75	6.09	Yes	No	0	4	6
53	R:R:I80	R:R:V76	4.61	Yes	No	0	6	7
54	R:R:T278	R:R:V76	6.35	No	No	0	8	7
55	R:R:F78	R:R:F79	5.36	No	Yes	0	5	4
56	R:R:F79	R:R:L107	12.18	Yes	No	0	4	5
57	R:R:F79	R:R:S111	6.61	Yes	No	0	4	7
58	R:R:E108	R:R:I80	9.56	Yes	Yes	1	5	6
59	R:R:I80	R:R:L275	4.28	Yes	No	1	6	6
60	L:L:?1	R:R:I80	5.42	Yes	Yes	1	0	6
61	R:R:I104	R:R:V83	9.22	No	No	0	4	6
62	R:R:D84	R:R:E88	11.69	Yes	No	0	4	3
63	R:R:D84	R:R:I104	5.6	Yes	No	0	4	4
64	R:R:D84	R:R:E105	6.5	Yes	No	1	4	4
65	R:R:D84	R:R:E108	11.69	Yes	Yes	1	4	5
66	R:R:D89	R:R:F85	3.58	No	Yes	0	3	5
67	R:R:F85	R:R:N271	7.25	Yes	No	1	5	6
68	L:L:?1	R:R:F85	3.7	Yes	Yes	1	0	5
69	R:R:I91	R:R:L87	7.14	No	No	0	3	4
70	R:R:E88	R:R:Q95	8.92	No	No	0	3	4
71	R:R:D101	R:R:E88	9.09	No	No	0	9	3
72	R:R:F90	R:R:I91	6.28	No	No	0	4	3
73	R:R:L92	R:R:M94	8.48	No	No	0	3	6
74	R:R:P100	R:R:Q95	9.47	No	No	0	4	4
75	R:R:M96	R:R:P97	5.03	No	No	0	5	6
76	R:R:M96	R:R:Q98	9.52	No	No	0	5	4
77	R:R:M96	R:R:P100	5.03	No	No	0	5	4
78	R:R:P100	R:R:V99	3.53	No	No	0	4	1
79	R:R:D101	R:R:E105	3.9	No	No	0	9	4
80	R:R:K102	R:R:Y164	17.91	No	No	0	6	5
81	R:R:E105	R:R:E108	10.15	No	Yes	1	4	5
82	L:L:?1	R:R:E108	8.05	Yes	Yes	1	0	5
83	R:R:F109	R:R:I112	5.02	Yes	No	1	5	6
84	R:R:F109	R:R:Y163	20.63	Yes	Yes	1	5	4
85	R:R:F109	R:R:W166	20.04	Yes	Yes	1	5	5
86	R:R:F109	R:R:H187	6.79	Yes	Yes	1	5	5
87	L:L:?1	R:R:F109	4.63	Yes	Yes	1	0	5
88	R:R:F157	R:R:S110	9.25	No	No	0	4	5
89	R:R:S110	R:R:S160	6.52	No	Yes	0	5	7
90	R:R:H113	R:R:I112	6.63	Yes	No	1	6	6
91	L:L:?1	R:R:I112	5.42	Yes	No	1	0	6
92	R:R:H113	R:R:S160	5.58	Yes	Yes	1	6	7
93	R:R:H113	R:R:Y163	9.8	Yes	Yes	1	6	4
94	R:R:H113	R:R:T190	4.11	Yes	No	0	6	4
95	R:R:H113	R:R:V191	4.15	Yes	No	0	6	5
96	R:R:T114	R:R:Y153	8.74	No	No	0	6	7
97	R:R:S115	R:R:T278	4.8	No	No	5	9	8
98	R:R:I116	R:R:W117	3.52	No	No	0	7	7
99	R:R:I116	R:R:P195	5.08	No	No	0	7	9
100	R:R:F237	R:R:I116	5.02	Yes	No	0	9	7
101	R:R:V120	R:R:W117	13.48	Yes	No	0	8	7
102	R:R:I118	R:R:V152	4.61	No	No	0	7	7
103	R:R:F199	R:R:T119	7.78	No	No	0	8	8
104	R:R:T119	R:R:Y285	4.99	No	Yes	0	8	9
105	R:R:P121	R:R:V120	3.53	No	Yes	0	7	8
106	R:R:I198	R:R:V120	4.61	No	Yes	0	6	8
107	R:R:P121	R:R:V148	3.53	No	No	2	7	6
108	R:R:L122	R:R:R126	3.64	No	No	0	8	9
109	R:R:L122	R:R:Y285	3.52	No	Yes	0	8	9
110	R:R:F199	R:R:T123	6.49	No	No	0	8	9
111	R:R:L202	R:R:T123	5.9	No	No	0	7	9
112	R:R:N203	R:R:T123	4.39	Yes	No	0	9	9
113	R:R:D125	R:R:Y136	9.2	Yes	Yes	2	9	7
114	R:R:D125	R:R:S140	8.83	Yes	No	2	9	8
115	R:R:I128	R:R:Y127	3.63	No	Yes	0	7	8
116	R:R:C131	R:R:Y127	6.72	Yes	Yes	3	7	8
117	R:R:H132	R:R:Y127	5.44	Yes	Yes	3	7	8
118	R:R:L202	R:R:Y127	4.69	No	Yes	0	7	8
119	R:R:I205	R:R:Y127	3.63	No	Yes	0	5	8
120	R:R:I206	R:R:Y127	3.63	No	Yes	3	8	8
121	R:R:A129	R:R:Y136	9.34	No	Yes	0	8	7
122	R:R:C131	R:R:H132	4.42	Yes	Yes	3	7	7
123	R:R:C131	R:R:K209	9.7	Yes	No	0	7	5
124	R:R:H137	R:R:Y136	10.89	No	Yes	0	5	7
125	R:R:S140	R:R:Y136	3.82	No	Yes	2	8	7
126	R:R:R144	R:R:Y141	22.64	No	No	0	6	8
127	R:R:S160	R:R:Y163	5.09	Yes	Yes	1	7	4
128	R:R:W166	R:R:Y163	3.86	Yes	Yes	1	5	4
129	R:R:L183	R:R:Y163	8.21	No	Yes	0	5	4
130	R:R:H187	R:R:Y163	9.8	Yes	Yes	1	5	4
131	R:R:W165	R:R:Y164	21.22	No	No	0	5	5
132	R:R:P167	R:R:W166	12.16	No	Yes	0	4	5
133	R:R:I184	R:R:W166	3.52	No	Yes	0	4	5
134	R:R:H187	R:R:W166	4.23	Yes	Yes	1	5	5
135	L:L:?1	R:R:W166	6.92	Yes	Yes	1	0	5
136	R:R:H180	R:R:P167	12.2	Yes	No	0	4	4
137	R:R:N168	R:R:T171	14.62	No	No	0	3	1
138	R:R:H251	R:R:I169	7.95	No	No	0	4	4
139	L:L:?1	R:R:I169	7.59	Yes	No	0	0	4
140	R:R:H264	R:R:W170	8.46	No	No	0	3	2
141	R:R:S267	R:R:W170	7.41	No	No	0	4	2
142	L:L:?1	R:R:W170	11.25	Yes	No	0	0	2
143	R:R:E172	R:R:Y174	13.47	No	No	0	4	6
144	R:R:D173	R:R:R260	9.53	No	No	0	3	1
145	R:R:H180	R:R:S176	4.18	Yes	No	0	4	3
146	R:R:H180	R:R:T177	5.48	Yes	No	0	4	1
147	R:R:H180	R:R:V179	6.92	Yes	No	0	4	4
148	R:R:I184	R:R:I248	5.89	No	No	0	4	5
149	R:R:W185	R:R:Y253	3.86	No	No	0	4	4
150	R:R:H187	R:R:V191	8.3	Yes	No	0	5	5
151	R:R:H187	R:R:R244	5.64	Yes	Yes	1	5	5
152	R:R:F189	R:R:L193	6.09	No	No	0	4	4
153	R:R:V191	R:R:W241	7.36	No	Yes	0	5	8
154	R:R:L193	R:R:Y192	3.52	No	No	0	4	7
155	R:R:I245	R:R:Y192	7.25	Yes	No	0	7	7
156	R:R:P195	R:R:V194	3.53	No	No	0	9	5
157	R:R:F199	R:R:F237	5.36	No	Yes	0	8	9
158	R:R:F200	R:R:T234	7.78	No	No	0	5	8
159	R:R:I206	R:R:N203	5.66	No	Yes	3	8	9
160	R:R:L230	R:R:N203	9.61	No	Yes	3	8	9
161	R:R:N203	R:R:T234	4.39	Yes	No	0	9	8
162	R:R:I206	R:R:L230	5.71	No	No	3	8	8
163	R:R:T227	R:R:V207	6.35	No	No	0	8	6
164	R:R:R212	R:R:Y208	16.46	No	No	0	5	3
165	R:R:K209	R:R:K213	7.18	No	No	0	5	6
166	R:R:L210	R:R:T226	4.42	No	No	0	8	7
167	R:R:R211	R:R:T223	6.47	No	Yes	0	4	6
168	R:R:K213	R:R:S214	6.12	No	No	0	6	5
169	R:R:L218	R:R:N215	6.87	No	No	0	4	4
170	R:R:R217	R:R:R219	4.26	No	No	0	6	4
171	R:R:R219	R:R:S222	10.54	No	No	0	4	5
172	R:R:K225	R:R:Y221	4.78	No	No	0	7	3
173	R:R:G224	R:R:T223	3.64	No	Yes	0	4	6
174	R:R:F231	R:R:T227	3.89	No	No	0	6	8
175	R:R:I233	R:R:L284	8.56	No	No	0	8	8
176	R:R:I233	R:R:Y285	4.84	No	Yes	0	8	9
177	R:R:I236	R:R:T239	4.56	No	No	0	6	5
178	R:R:I236	R:R:L240	7.14	No	No	0	6	8
179	R:R:I236	R:R:I280	4.42	No	No	0	6	6
180	R:R:F237	R:R:W241	6.01	Yes	Yes	1	9	8
181	R:R:F237	R:R:N277	7.25	Yes	Yes	1	9	9
182	R:R:L240	R:R:N277	10.98	No	Yes	0	8	9
183	R:R:R244	R:R:W241	5	Yes	Yes	1	5	8
184	R:R:I245	R:R:W241	4.7	Yes	Yes	0	7	8
185	R:R:A274	R:R:W241	5.19	No	Yes	0	7	8
186	R:R:N277	R:R:W241	7.91	Yes	Yes	1	9	8
187	R:R:A242	R:R:P243	3.74	No	No	0	5	8
188	R:R:I248	R:R:R244	3.76	No	Yes	0	5	5
189	R:R:N271	R:R:R244	7.23	No	Yes	1	6	5
190	L:L:?1	R:R:R244	21.22	Yes	Yes	1	0	5
191	R:R:M247	R:R:M266	10.11	No	No	0	4	4
192	R:R:G254	R:R:Y250	5.79	No	No	0	3	4
193	R:R:N259	R:R:W261	5.65	No	No	0	2	2
194	R:R:L262	R:R:N259	5.49	No	No	0	3	2
195	R:R:I265	R:R:W261	16.44	No	No	0	3	2
196	R:R:D268	R:R:M272	5.54	No	Yes	0	5	6
197	L:L:?1	R:R:N271	19.81	Yes	No	1	0	6
198	L:L:?1	R:R:L275	7.36	Yes	No	1	0	6
199	R:R:N277	R:R:N281	5.45	Yes	No	0	9	9
200	R:R:N281	R:R:Y285	8.14	No	Yes	0	9	9
201	R:R:F282	R:R:F283	16.08	Yes	No	0	9	6
202	R:R:C286	R:R:F282	5.59	No	Yes	0	7	9
203	R:R:F283	R:R:F287	6.43	No	No	0	6	7
204	R:R:C286	R:R:F292	12.57	No	Yes	0	7	9
205	R:R:F287	R:R:R293	7.48	No	No	0	7	9
206	R:R:K290	R:R:R293	9.9	No	No	0	5	9
207	R:R:C131	R:R:V130	3.42	Yes	No	0	7	8
208	R:R:I161	R:R:P162	3.39	No	No	0	5	7
209	R:R:C156	R:R:T114	3.38	No	No	0	7	6
210	R:R:A70	R:R:T47	3.36	No	No	0	9	8
211	R:R:A72	R:R:T114	3.36	No	No	0	8	6
212	R:R:L134	R:R:P133	3.28	No	No	0	6	8
213	R:R:C188	R:R:I245	3.27	No	Yes	0	5	7
214	R:R:C188	R:R:I248	3.27	No	No	0	5	5
215	R:R:N64	R:R:P142	3.26	No	No	0	5	3
216	R:R:A255	R:R:I257	3.25	No	No	0	1	1
217	R:R:S34	R:R:V31	3.23	No	No	0	5	6
218	R:R:S111	R:R:V76	3.23	No	No	0	7	7
219	R:R:S178	R:R:T177	3.2	No	No	0	1	1
220	R:R:I124	R:R:V120	3.07	No	Yes	0	6	8
221	R:R:F189	R:R:W185	3.01	No	No	0	4	4
222	R:R:L66	R:R:V62	2.98	No	No	0	9	8
223	R:R:L210	R:R:V130	2.98	No	No	0	8	8
224	R:R:C156	R:R:H113	2.95	No	Yes	0	7	6
225	R:R:L284	R:R:T232	2.95	No	No	0	8	5
226	R:R:I45	R:R:I74	2.94	No	No	0	4	7
227	R:R:I229	R:R:I233	2.94	No	No	0	8	8
228	R:R:I229	R:R:I288	2.94	No	No	0	8	7
229	R:R:I50	R:R:M295	2.92	Yes	No	0	8	6
230	R:R:I269	R:R:M266	2.92	No	No	0	5	4
231	R:R:I269	R:R:M272	2.92	No	Yes	0	5	6
232	R:R:I229	R:R:K225	2.91	No	No	0	8	7
233	R:R:I265	R:R:L25	2.85	No	No	0	3	3
234	R:R:I91	R:R:L86	2.85	No	No	0	3	4
235	R:R:I154	R:R:L158	2.85	No	No	0	4	4
236	R:R:I245	R:R:L249	2.85	Yes	No	0	7	5
237	R:R:I74	R:R:N44	2.83	No	No	0	7	9
238	R:R:E172	R:R:T171	2.82	No	No	0	4	1
239	R:R:C196	R:R:F237	2.79	No	Yes	0	6	9
240	R:R:L37	R:R:L86	2.77	Yes	No	0	7	4
241	R:R:L240	R:R:L273	2.77	No	No	0	8	8
242	R:R:K60	R:R:Q59	2.71	No	No	0	7	7
243	R:R:A143	R:R:Y141	2.67	No	No	0	4	8
244	R:R:F292	R:R:S289	2.64	Yes	No	0	9	9
245	R:R:H251	R:R:L252	2.57	No	No	0	4	5
246	R:R:K60	R:R:R291	2.48	No	No	0	7	7
247	R:R:M247	R:R:Y250	2.39	No	No	0	4	4
248	R:R:H180	R:R:Y174	2.18	Yes	No	0	4	6
249	R:R:F216	R:R:R217	2.14	No	No	0	4	6
250	R:R:G26	R:R:P29	2.03	No	No	0	3	5
251	R:R:A255	R:R:G254	1.95	No	No	0	1	3
252	R:R:A270	R:R:P243	1.87	No	No	0	6	8
253	R:R:A255	R:R:P256	1.87	No	No	0	1	1
254	R:R:G220	R:R:T223	1.82	No	Yes	0	4	6
255	R:R:G40	R:R:L39	1.71	No	No	0	9	6
256	R:R:G40	R:R:L77	1.71	No	No	0	9	7
257	R:R:L41	R:R:P42	1.64	No	No	0	7	4
258	R:R:L183	R:R:P162	1.64	No	No	0	5	7
259	R:R:L273	R:R:P243	1.64	No	No	0	8	8
260	R:R:A296	R:R:I50	1.62	No	Yes	0	6	8
261	R:R:S160	R:R:V106	1.62	Yes	No	0	7	5
262	R:R:A242	R:R:I246	1.62	No	No	0	5	6
263	R:R:A143	R:R:K147	1.61	No	No	0	4	3
264	R:R:S151	R:R:T155	1.6	No	No	0	4	3
265	R:R:S222	R:R:T223	1.6	No	Yes	0	5	6
266	R:R:S235	R:R:T234	1.6	No	No	0	5	8
267	R:R:A279	R:R:L36	1.58	No	No	0	7	7
268	R:R:A279	R:R:L39	1.58	No	No	0	7	6
269	R:R:A279	R:R:L276	1.58	No	No	0	7	6
270	R:R:T155	R:R:T159	1.57	No	No	0	3	4
271	R:R:I201	R:R:S197	1.55	No	No	0	5	3
272	R:R:I103	R:R:V99	1.54	No	No	0	4	1
273	R:R:I186	R:R:V182	1.54	No	No	0	4	4
274	R:R:H132	R:R:P133	1.53	Yes	No	0	7	8
275	R:R:M295	R:R:V55	1.52	No	No	0	6	4
276	R:R:K135	R:R:V139	1.52	No	No	0	5	4
277	R:R:L230	R:R:V207	1.49	No	No	0	8	6
278	R:R:L210	R:R:T223	1.47	No	Yes	0	8	6
279	R:R:Q53	R:R:V55	1.43	No	No	0	5	4
280	R:R:D173	R:R:I169	1.4	No	No	0	3	4
281	R:R:P142	R:R:Y141	1.39	No	No	0	3	8
282	R:R:H181	R:R:S176	1.39	No	No	0	2	3
283	R:R:H181	R:R:S178	1.39	No	No	0	2	1
284	R:R:A238	R:R:F200	1.39	No	No	0	6	5
285	R:R:I49	R:R:Q53	1.37	No	No	0	5	5
286	R:R:A71	R:R:Y153	1.33	No	No	0	6	7
287	R:R:H132	R:R:K135	1.31	Yes	No	0	7	5
288	R:R:R144	R:R:V139	1.31	No	No	0	6	4
289	R:R:F303	R:R:T299	1.3	No	No	0	2	5
290	R:R:R291	R:R:T294	1.29	No	No	0	7	4
291	R:R:V106	R:R:Y164	1.26	No	No	0	5	5
292	R:R:F304	R:R:L300	1.22	No	No	0	2	5
293	R:R:I186	R:R:Y163	1.21	No	Yes	0	4	4
294	L:L:?1	R:R:V263	1.13	Yes	No	0	0	3
295	R:R:R211	R:R:R212	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y33	10.988	5	0	7
2	R:R:L37	5.308	5	4	7
3	R:R:I50	5.96	4	0	8
4	R:R:S61	5.5675	4	2	7
5	R:R:Y63	9.34	4	0	8
6	R:R:Y65	6.756	5	2	8
7	R:R:D73	5.9275	4	5	9
8	R:R:F79	7.56	4	0	4
9	R:R:I80	5.9675	4	1	6
10	R:R:D84	8.87	4	1	4
11	R:R:F85	11.6275	4	1	5
12	R:R:E108	9.8625	4	1	5
13	R:R:F109	11.422	5	1	5
14	R:R:H113	5.53667	6	1	6
15	R:R:V120	6.1725	4	0	8
16	R:R:D125	7.705	4	2	9
17	R:R:Y127	4.62333	6	3	8
18	R:R:C131	6.065	4	3	7
19	R:R:H132	3.175	4	3	7
20	R:R:Y136	7.668	5	2	7
21	R:R:S160	4.7025	4	1	7
22	R:R:Y163	8.37143	7	1	4
23	R:R:W166	8.455	6	1	5
24	R:R:H180	6.192	5	0	4
25	R:R:H187	6.952	5	1	5
26	R:R:N203	6.0125	4	3	9
27	R:R:T223	3	5	0	6
28	R:R:F237	5.286	5	1	9
29	R:R:W241	6.02833	6	1	8
30	R:R:R244	8.57	5	1	5
31	R:R:I245	4.5175	4	0	7
32	R:R:M272	6.9025	4	0	6
33	R:R:N277	7.8975	4	1	9
34	R:R:F282	7.742	5	0	9
35	R:R:Y285	5.002	5	0	9
36	R:R:F292	6.3175	4	0	9
37	L:L:?1	8.54167	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L25	R:R:V28	17.963	4.47	No	No	0	3	4
2	R:R:P29	R:R:V28	21.5262	5.3	No	No	0	5	4
3	R:R:D268	R:R:P29	28.6	8.05	No	No	0	5	5
4	R:R:I91	R:R:L86	13.5117	2.85	No	No	0	3	4
5	R:R:L37	R:R:L86	16.8383	2.77	Yes	No	0	7	4
6	R:R:L37	R:R:V81	31.1541	10.43	Yes	No	0	7	7
7	R:R:V81	R:R:Y33	34.0866	7.57	No	Yes	0	7	7
8	R:R:M272	R:R:Y33	63.0755	7.18	Yes	Yes	0	6	7
9	R:R:D268	R:R:M272	31.769	5.54	No	Yes	0	5	6
10	R:R:M272	R:R:Y32	10.8577	11.97	Yes	No	0	6	5
11	R:R:L36	R:R:Y33	23.4549	3.52	No	Yes	0	7	7
12	R:R:F85	R:R:Y33	61.9666	31.98	Yes	Yes	0	5	7
13	R:R:L275	R:R:Y33	47.099	4.69	No	Yes	0	6	7
14	R:R:F283	R:R:L39	22.6719	3.65	No	No	0	6	6
15	R:R:A279	R:R:L39	21.7889	1.58	No	No	0	7	6
16	R:R:A279	R:R:L36	20.8219	1.58	No	No	0	7	7
17	R:R:F282	R:R:F283	20.9271	16.08	Yes	No	0	9	6
18	R:R:D73	R:R:T278	31.07	5.78	Yes	No	5	9	8
19	R:R:T278	R:R:V76	31.769	6.35	No	No	0	8	7
20	R:R:I80	R:R:V76	35.2375	4.61	Yes	No	0	6	7
21	R:R:F282	R:R:N44	60.9575	4.83	Yes	No	0	9	9
22	R:R:D73	R:R:N44	63.2909	8.08	Yes	No	0	9	9
23	R:R:I50	R:R:M295	16.1078	2.92	Yes	No	0	8	6
24	R:R:M295	R:R:Y63	28.8259	3.59	No	Yes	0	6	8
25	R:R:L51	R:R:Y63	47.5983	4.69	No	Yes	0	7	8
26	R:R:F292	R:R:L51	56.6796	4.87	Yes	No	0	9	7
27	R:R:F292	R:R:T47	31.3748	5.19	Yes	No	0	9	8
28	R:R:F282	R:R:T47	34.2758	3.89	Yes	No	0	9	8
29	R:R:C286	R:R:F292	31.2802	12.57	No	Yes	0	7	9
30	R:R:C286	R:R:F282	32.7412	5.59	No	Yes	0	7	9
31	R:R:F85	R:R:N271	22.6719	7.25	Yes	No	1	5	6
32	R:R:N271	R:R:R244	22.8716	7.23	No	Yes	1	6	5
33	R:R:R244	R:R:W241	100	5	Yes	Yes	1	5	8
34	R:R:F237	R:R:W241	89.1265	6.01	Yes	Yes	1	9	8
35	R:R:F237	R:R:I116	57.9672	5.02	Yes	No	0	9	7
36	R:R:I116	R:R:W117	51.5976	3.52	No	No	0	7	7
37	R:R:V120	R:R:W117	49.4639	13.48	Yes	No	0	8	7
38	R:R:P121	R:R:V120	43.0313	3.53	No	Yes	0	7	8
39	R:R:P121	R:R:Y65	38.6168	6.95	No	Yes	2	7	8
40	R:R:T145	R:R:Y65	15.9344	9.99	No	Yes	0	8	8
41	R:R:N64	R:R:T145	12.7969	4.39	No	No	0	5	8
42	L:L:?1	R:R:F85	41.5493	3.7	Yes	Yes	1	0	5
43	L:L:?1	R:R:R244	70.0021	21.22	Yes	Yes	1	0	5
44	L:L:?1	R:R:L275	40.3878	7.36	Yes	No	1	0	6
45	R:R:K60	R:R:Y63	12.9126	25.08	No	Yes	0	7	8
46	R:R:D125	R:R:Y65	13.3435	6.9	Yes	Yes	2	9	8
47	R:R:L69	R:R:Y285	45.0809	3.52	No	Yes	0	9	9
48	R:R:D73	R:R:L69	45.0389	5.43	Yes	No	0	9	9
49	R:R:N281	R:R:Y285	30.0347	8.14	No	Yes	0	9	9
50	R:R:N277	R:R:N281	31.0069	5.45	Yes	No	0	9	9
51	R:R:N277	R:R:W241	29.8087	7.91	Yes	Yes	1	9	8
52	L:L:?1	R:R:E108	19.4766	8.05	Yes	Yes	1	0	5
53	R:R:D84	R:R:E108	22.2619	11.69	Yes	Yes	1	4	5
54	R:R:D84	R:R:E88	16.4862	11.69	Yes	No	0	4	3
55	R:R:E88	R:R:Q95	14.526	8.92	No	No	0	3	4
56	R:R:P100	R:R:Q95	12.4816	9.47	No	No	0	4	4
57	R:R:V106	R:R:Y164	10.3532	1.26	No	No	0	5	5
58	R:R:S160	R:R:V106	13.7849	1.62	Yes	No	0	7	5
59	R:R:H113	R:R:S160	10.5161	5.58	Yes	Yes	1	6	7
60	R:R:H113	R:R:I112	13.9058	6.63	Yes	No	1	6	6
61	L:L:?1	R:R:I112	14.7414	5.42	Yes	No	1	0	6
62	R:R:S160	R:R:Y163	13.4959	5.09	Yes	Yes	1	7	4
63	R:R:F109	R:R:Y163	11.5987	20.63	Yes	Yes	1	5	4
64	L:L:?1	R:R:F109	14.3788	4.63	Yes	Yes	1	0	5
65	R:R:W166	R:R:Y163	13.0544	3.86	Yes	Yes	1	5	4
66	L:L:?1	R:R:W166	31.0385	6.92	Yes	Yes	1	0	5
67	R:R:H187	R:R:W166	14.6731	4.23	Yes	Yes	1	5	5
68	R:R:H187	R:R:R244	13.2384	5.64	Yes	Yes	1	5	5
69	R:R:H187	R:R:V191	13.2594	8.3	Yes	No	0	5	5
70	R:R:V191	R:R:W241	24.3851	7.36	No	Yes	0	5	8
71	R:R:H113	R:R:V191	12.6077	4.15	Yes	No	0	6	5
72	R:R:F199	R:R:F237	66.7543	5.36	No	Yes	0	8	9
73	R:R:F199	R:R:T119	28.4581	7.78	No	No	0	8	8
74	R:R:F199	R:R:T123	71.6891	6.49	No	No	0	8	9
75	R:R:L202	R:R:T123	51.9708	5.9	No	No	0	7	9
76	R:R:N203	R:R:T123	18.21	4.39	Yes	No	0	9	9
77	R:R:L202	R:R:Y127	50.3101	4.69	No	Yes	0	7	8
78	R:R:C131	R:R:Y127	30.2396	6.72	Yes	Yes	3	7	8
79	R:R:H132	R:R:Y127	16.8804	5.44	Yes	Yes	3	7	8
80	R:R:H132	R:R:K135	13.8375	1.31	Yes	No	0	7	5
81	R:R:K135	R:R:V139	12.0559	1.52	No	No	0	5	4
82	R:R:R144	R:R:V139	10.2691	1.31	No	No	0	6	4
83	R:R:L183	R:R:Y163	11.0626	8.21	No	Yes	0	5	4
84	R:R:P167	R:R:W166	30.0505	12.16	No	Yes	0	4	5
85	R:R:H180	R:R:P167	27.3492	12.2	Yes	No	0	4	4
86	R:R:H180	R:R:Y174	10.9207	2.18	Yes	No	0	4	6
87	R:R:I245	R:R:W241	15.1987	4.7	Yes	Yes	0	7	8
88	R:R:I245	R:R:Y192	10.637	7.25	Yes	No	0	7	7
89	R:R:C131	R:R:V130	25.1577	3.42	Yes	No	0	7	8
90	R:R:L210	R:R:V130	23.2289	2.98	No	No	0	8	8
91	R:R:L210	R:R:T223	19.7498	1.47	No	Yes	0	8	6
92	R:R:I233	R:R:Y285	16.2497	4.84	No	Yes	0	8	9
93	R:R:L240	R:R:N277	18.252	10.98	No	Yes	0	8	9
94	R:R:L240	R:R:L273	10.2428	2.77	No	No	0	8	8
95	R:R:I269	R:R:M272	28.4423	2.92	No	Yes	0	5	6
96	R:R:I269	R:R:M266	24.9001	2.92	No	No	0	5	4
97	R:R:M247	R:R:M266	21.3475	10.11	No	No	0	4	4
98	R:R:G254	R:R:Y250	14.3946	5.79	No	No	0	3	4
99	R:R:M247	R:R:Y250	17.9683	2.39	No	No	0	4	4
100	R:R:I265	R:R:L25	14.3893	2.85	No	No	0	3	3
101	R:R:I265	R:R:W261	10.8104	16.44	No	No	0	3	2
102	R:R:A255	R:R:G254	10.8104	1.95	No	No	0	1	3
103	R:R:T119	R:R:Y285	27.3965	4.99	No	Yes	0	8	9
104	L:L:?1	R:R:I80	25.8356	5.42	Yes	Yes	1	0	6
105	R:R:F237	R:R:N277	13.8585	7.25	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F85	R:R:Y33	31.98	1	Yes	Yes	5	7	1	2
R:R:L275	R:R:Y33	4.69	1	No	Yes	6	7	1	2
R:R:I80	R:R:V76	4.61	1	Yes	No	6	7	1	2
R:R:E108	R:R:I80	9.56	1	Yes	Yes	5	6	1	1
R:R:I80	R:R:L275	4.28	1	Yes	No	6	6	1	1
L:L:?1	R:R:I80	5.42	1	Yes	Yes	0	6	0	1
R:R:D84	R:R:E105	6.5	1	Yes	No	4	4	2	2
R:R:D84	R:R:E108	11.69	1	Yes	Yes	4	5	2	1
R:R:D89	R:R:F85	3.58	0	No	Yes	3	5	2	1
R:R:F85	R:R:N271	7.25	1	Yes	No	5	6	1	1
L:L:?1	R:R:F85	3.7	1	Yes	Yes	0	5	0	1
R:R:E105	R:R:E108	10.15	1	No	Yes	4	5	2	1
L:L:?1	R:R:E108	8.05	1	Yes	Yes	0	5	0	1
R:R:F109	R:R:I112	5.02	1	Yes	No	5	6	1	1
R:R:F109	R:R:Y163	20.63	1	Yes	Yes	5	4	1	2
R:R:F109	R:R:W166	20.04	1	Yes	Yes	5	5	1	1
R:R:F109	R:R:H187	6.79	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:F109	4.63	1	Yes	Yes	0	5	0	1
R:R:H113	R:R:I112	6.63	1	Yes	No	6	6	2	1
L:L:?1	R:R:I112	5.42	1	Yes	No	0	6	0	1
R:R:H113	R:R:Y163	9.8	1	Yes	Yes	6	4	2	2
R:R:W166	R:R:Y163	3.86	1	Yes	Yes	5	4	1	2
R:R:H187	R:R:Y163	9.8	1	Yes	Yes	5	4	2	2
R:R:P167	R:R:W166	12.16	0	No	Yes	4	5	2	1
R:R:I184	R:R:W166	3.52	0	No	Yes	4	5	2	1
R:R:H187	R:R:W166	4.23	1	Yes	Yes	5	5	2	1
L:L:?1	R:R:W166	6.92	1	Yes	Yes	0	5	0	1
R:R:H251	R:R:I169	7.95	0	No	No	4	4	2	1
L:L:?1	R:R:I169	7.59	1	Yes	No	0	4	0	1
R:R:H264	R:R:W170	8.46	0	No	No	3	2	2	1
R:R:S267	R:R:W170	7.41	0	No	No	4	2	2	1
L:L:?1	R:R:W170	11.25	1	Yes	No	0	2	0	1
R:R:I184	R:R:I248	5.89	0	No	No	4	5	2	2
R:R:H187	R:R:R244	5.64	1	Yes	Yes	5	5	2	1
R:R:R244	R:R:W241	5	1	Yes	Yes	5	8	1	2
R:R:I248	R:R:R244	3.76	0	No	Yes	5	5	2	1
R:R:N271	R:R:R244	7.23	1	No	Yes	6	5	1	1
L:L:?1	R:R:R244	21.22	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N271	19.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:L275	7.36	1	Yes	No	0	6	0	1
R:R:D173	R:R:I169	1.4	0	No	No	3	4	2	1
L:L:?1	R:R:V263	1.13	1	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VUG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	266
Number of Links	295
Number of Hubs	37
Number of Links mediated by Hubs	147
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	59534
Length Of Smallest Path	3
Average Path Length	12.6895
Length of Longest Path	27
Minimum Path Strength	1.375
Average Path Strength	6.77
Maximum Path Strength	19.775
Minimum Path Correlation	0.7
Average Path Correlation	0.925101
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	45.8299
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5365
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • identical protein binding • xylanase activity • hydrolase activity, acting on glycosyl bonds • endo-1,4-beta-xylanase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • carbohydrate metabolic process • xylan catabolic process • catabolic process • hemicellulose metabolic process • cell wall organization or biogenesis • carbohydrate catabolic process • hemicellulose catabolic process • primary metabolic process • macromolecule catabolic process • cell wall macromolecule catabolic process • xylan metabolic process • polysaccharide metabolic process • polysaccharide catabolic process • metabolic process • macromolecule metabolic process • cell wall polysaccharide metabolic process • cell wall macromolecule metabolic process • cell wall polysaccharide catabolic process
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7ZQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7ZQ
Name	3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Synonyms
Identifier
Formula	C17 H17 Cl N2 O2
Molecular Weight	316.782
SMILES
PubChem	2548547
Formal Charge	0
Total Atoms	39
Total Chiral Atoms	1
Total Bonds	40
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6DWJ6
Sequence	>7VUG_nogp_Chain_R C G L G F V P V V Y Y S L L L C L G L P A N I L T V I I L S Q L V A R R Q K S V Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L N M Q M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H P L K Y H T V S Y P A R T R K V I V S V Y I T C F L T S I P Y Y W W P N I W T E D Y I S T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K S N F R L R G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G A P I Q N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R F R T M A A A T L K A F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VUJ	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP	chim(Gs-CtGq)/β1/γ2	3.8	2021-12-29	10.1038/s41422-021-00591-w
	7VUJ (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP		3.8	2021-12-29	10.1038/s41422-021-00591-w
	7VUI	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP	chim(Gs-CtGq)/β1/γ2	3.3	2021-12-29	10.1038/s41422-021-00591-w
	7VUI (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP		3.3	2021-12-29	10.1038/s41422-021-00591-w
	7VUH	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	chim(Gs-CtGq)/β1/γ2	3.22	2021-12-29	10.1038/s41422-021-00591-w
	7VUH (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.22	2021-12-29	10.1038/s41422-021-00591-w
	7VUG	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	Gi1/β1/γ2	3.2	2021-12-29	10.1038/s41422-021-00591-w
	7VUG (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.2	2021-12-29	10.1038/s41422-021-00591-w

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