psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F27	R:R:V30	7.87	No	No	0	3	4
2	R:R:P29	R:R:V28	5.3	No	No	0	5	4
3	R:R:F90	R:R:V30	3.93	No	No	0	4	4
4	R:R:Y32	R:R:Y33	7.94	Yes	Yes	3	5	7
5	R:R:L36	R:R:Y32	5.86	No	Yes	0	7	5
6	R:R:M272	R:R:Y32	16.76	No	Yes	3	6	5
7	R:R:L276	R:R:Y32	4.69	No	Yes	0	6	5
8	R:R:V81	R:R:Y33	3.79	Yes	Yes	0	7	7
9	R:R:F85	R:R:Y33	10.32	No	Yes	0	5	7
10	R:R:M272	R:R:Y33	10.78	No	Yes	3	6	7
11	R:R:L36	R:R:V81	2.98	No	Yes	0	7	7
12	R:R:A279	R:R:L36	3.15	No	No	0	7	7
13	R:R:L37	R:R:L41	4.15	No	No	0	7	7
14	R:R:L37	R:R:V81	5.96	No	Yes	0	7	7
15	R:R:L41	R:R:L77	5.54	No	No	0	7	7
16	R:R:D73	R:R:N44	5.39	No	No	0	9	9
17	R:R:F282	R:R:N44	6.04	Yes	No	0	9	9
18	R:R:I45	R:R:I74	2.94	No	No	0	4	7
19	R:R:I49	R:R:L46	2.85	No	No	0	5	6
20	R:R:I50	R:R:L46	4.28	No	No	0	8	6
21	R:R:F282	R:R:T47	6.49	Yes	No	0	9	8
22	R:R:F292	R:R:T47	6.49	No	No	0	9	8
23	R:R:I74	R:R:V48	3.07	No	No	0	7	7
24	R:R:I50	R:R:T299	6.08	No	No	0	8	5
25	R:R:L51	R:R:Y63	4.69	No	Yes	0	7	8
26	R:R:L51	R:R:L67	8.3	No	No	0	7	6
27	R:R:Q53	R:R:S52	2.89	No	No	0	5	4
28	R:R:A56	R:R:Q59	3.03	No	No	0	7	7
29	R:R:R57	R:R:R58	6.4	No	No	0	7	6
30	R:R:N64	R:R:R57	6.03	No	No	0	5	7
31	R:R:K60	R:R:Y63	4.78	No	Yes	0	7	8
32	R:R:S140	R:R:S61	4.89	Yes	No	0	8	7
33	R:R:S61	R:R:T145	4.8	No	No	0	7	8
34	R:R:L122	R:R:V62	2.98	No	No	0	8	8
35	R:R:R291	R:R:Y63	8.23	No	Yes	0	7	8
36	R:R:N64	R:R:T145	4.39	No	No	0	5	8
37	R:R:P121	R:R:Y65	6.95	No	Yes	0	7	8
38	R:R:L122	R:R:Y65	3.52	No	Yes	0	8	8
39	R:R:V148	R:R:Y65	6.31	No	Yes	0	6	8
40	R:R:C286	R:R:L66	4.76	No	No	0	7	9
41	R:R:A68	R:R:I118	4.87	No	No	0	8	7
42	R:R:A68	R:R:I149	3.25	No	No	0	8	7
43	R:R:D73	R:R:L69	4.07	No	Yes	0	9	9
44	R:R:I118	R:R:L69	4.28	No	Yes	0	7	9
45	R:R:L69	R:R:T119	4.42	Yes	Yes	2	9	8
46	R:R:L69	R:R:N281	6.87	Yes	No	2	9	9
47	R:R:L75	R:R:S111	3	No	No	0	6	7
48	R:R:I80	R:R:V76	3.07	No	No	1	6	7
49	R:R:S111	R:R:V76	3.23	No	No	0	7	7
50	R:R:I112	R:R:V76	3.07	No	No	1	6	7
51	R:R:L77	R:R:T278	2.95	No	No	0	7	8
52	R:R:F78	R:R:F79	5.36	No	No	0	5	4
53	R:R:F79	R:R:L107	7.31	No	No	0	4	5
54	R:R:E108	R:R:I80	6.83	Yes	No	0	5	6
55	R:R:I112	R:R:I80	2.94	No	No	1	6	6
56	R:R:L275	R:R:V81	2.98	No	Yes	0	6	7
57	R:R:D84	R:R:F85	13.14	No	No	0	4	5
58	R:R:D84	R:R:E88	7.8	No	No	0	4	3
59	R:R:D84	R:R:E108	11.69	No	Yes	0	4	5
60	R:R:F90	R:R:L86	3.65	No	No	0	4	4
61	R:R:L87	R:R:L92	8.3	No	No	0	4	3
62	R:R:E88	R:R:N93	6.57	No	No	0	3	4
63	R:R:D89	R:R:F90	5.97	No	No	0	3	4
64	R:R:L92	R:R:Q95	11.98	No	No	0	3	4
65	R:R:P100	R:R:Q95	11.05	Yes	No	0	4	4
66	R:R:M96	R:R:P100	6.71	No	Yes	0	5	4
67	R:R:D101	R:R:P97	3.22	No	No	0	9	6
68	R:R:P100	R:R:V99	5.3	Yes	No	0	4	1
69	R:R:K102	R:R:Y164	16.72	No	No	0	6	5
70	R:R:I103	R:R:Y164	3.63	No	No	0	4	5
71	R:R:E108	R:R:I104	5.47	Yes	No	0	5	4
72	R:R:E105	R:R:W166	13.08	No	Yes	0	4	5
73	L:L:?1	R:R:E108	3.02	Yes	Yes	0	0	5
74	R:R:F109	R:R:H113	3.39	Yes	No	1	5	6
75	R:R:F109	R:R:Y163	6.19	Yes	Yes	1	5	4
76	R:R:F109	R:R:W166	21.05	Yes	Yes	1	5	5
77	L:L:?1	R:R:F109	10.18	Yes	Yes	1	0	5
78	R:R:F157	R:R:S110	7.93	No	No	0	4	5
79	R:R:S110	R:R:S160	6.52	No	No	0	5	7
80	L:L:?1	R:R:I112	5.42	Yes	No	1	0	6
81	R:R:H113	R:R:Y163	7.62	No	Yes	1	6	4
82	R:R:H113	R:R:H187	8.36	No	No	1	6	5
83	R:R:T114	R:R:Y153	4.99	No	No	0	6	7
84	R:R:C156	R:R:T114	5.07	No	No	0	7	6
85	R:R:I116	R:R:V191	3.07	No	Yes	0	7	5
86	R:R:I116	R:R:P195	3.39	No	No	0	7	9
87	R:R:V120	R:R:W117	7.36	No	No	0	8	7
88	R:R:T190	R:R:W117	4.85	No	No	0	4	7
89	R:R:I118	R:R:V152	3.07	No	No	0	7	7
90	R:R:F199	R:R:T119	5.19	No	Yes	0	8	8
91	R:R:N281	R:R:T119	4.39	No	Yes	2	9	8
92	R:R:T119	R:R:Y285	3.75	Yes	Yes	2	8	9
93	R:R:P121	R:R:V120	5.3	No	No	0	7	8
94	R:R:I198	R:R:V120	4.61	No	No	0	6	8
95	R:R:I124	R:R:P121	3.39	No	No	0	6	7
96	R:R:R126	R:R:T123	6.47	Yes	No	0	9	9
97	R:R:F199	R:R:T123	14.27	No	No	0	8	9
98	R:R:L202	R:R:T123	2.95	Yes	No	0	7	9
99	R:R:I124	R:R:L202	2.85	No	Yes	0	6	7
100	R:R:D125	R:R:Y136	9.2	No	Yes	4	9	7
101	R:R:D125	R:R:S140	2.94	No	Yes	4	9	8
102	R:R:N203	R:R:R126	3.62	No	Yes	2	9	9
103	R:R:L230	R:R:R126	6.07	Yes	Yes	2	8	9
104	R:R:R126	R:R:Y285	3.09	Yes	Yes	2	9	9
105	R:R:C131	R:R:Y127	9.41	No	Yes	5	7	8
106	R:R:H132	R:R:Y127	3.27	Yes	Yes	5	7	8
107	R:R:L202	R:R:Y127	8.21	Yes	Yes	0	7	8
108	R:R:I206	R:R:Y127	3.63	No	Yes	0	8	8
109	R:R:H132	R:R:I128	5.3	Yes	No	0	7	7
110	R:R:A129	R:R:Y136	5.34	No	Yes	0	8	7
111	R:R:I206	R:R:V130	4.61	No	No	0	8	8
112	R:R:C131	R:R:H132	8.85	No	Yes	5	7	7
113	R:R:C131	R:R:K209	6.47	No	No	0	7	5
114	R:R:H132	R:R:K135	5.24	Yes	No	0	7	5
115	R:R:K135	R:R:L134	4.23	No	No	0	5	6
116	R:R:H137	R:R:Y136	7.62	No	Yes	0	5	7
117	R:R:S140	R:R:Y136	7.63	Yes	Yes	4	8	7
118	R:R:R144	R:R:Y141	24.69	No	No	0	6	8
119	R:R:K147	R:R:S151	6.12	No	No	0	3	4
120	R:R:S151	R:R:V148	3.23	No	No	0	4	6
121	R:R:I161	R:R:P162	3.39	No	No	0	5	7
122	R:R:W166	R:R:Y163	4.82	Yes	Yes	1	5	4
123	R:R:L183	R:R:Y163	5.86	No	Yes	1	5	4
124	R:R:H187	R:R:Y163	4.36	No	Yes	1	5	4
125	R:R:W165	R:R:Y164	7.72	No	No	0	5	5
126	R:R:P167	R:R:W166	9.46	No	Yes	1	4	5
127	R:R:L183	R:R:W166	3.42	No	Yes	1	5	5
128	R:R:I184	R:R:W166	3.52	No	Yes	0	4	5
129	L:L:?1	R:R:W166	3.46	Yes	Yes	1	0	5
130	R:R:P167	R:R:Y174	5.56	No	Yes	1	4	6
131	R:R:H180	R:R:P167	22.88	Yes	No	1	4	4
132	R:R:N168	R:R:T171	13.16	No	No	0	3	1
133	R:R:I169	R:R:W170	9.4	No	Yes	1	4	2
134	R:R:H251	R:R:I169	6.63	No	No	1	4	4
135	L:L:?1	R:R:I169	20.6	Yes	No	1	0	4
136	R:R:Q258	R:R:W170	8.76	No	Yes	1	1	2
137	R:R:V263	R:R:W170	6.13	No	Yes	1	3	2
138	R:R:H264	R:R:W170	10.58	No	Yes	0	3	2
139	R:R:S267	R:R:W170	3.71	No	Yes	0	4	2
140	R:R:D173	R:R:I175	5.6	No	No	0	3	2
141	R:R:H180	R:R:Y174	5.44	Yes	Yes	1	4	6
142	R:R:H251	R:R:Y174	11.98	No	Yes	1	4	6
143	R:R:I175	R:R:T177	3.04	No	No	0	2	1
144	R:R:T177	R:R:V179	4.76	No	No	1	1	4
145	R:R:H180	R:R:T177	17.8	Yes	No	1	4	1
146	R:R:H180	R:R:V179	4.15	Yes	No	1	4	4
147	R:R:L183	R:R:V179	2.98	No	No	1	5	4
148	R:R:H181	R:R:L252	3.86	No	No	0	2	5
149	R:R:I184	R:R:L252	4.28	No	No	0	4	5
150	R:R:F189	R:R:W185	7.02	No	No	0	4	4
151	R:R:L249	R:R:W185	5.69	No	No	0	5	4
152	R:R:W185	R:R:Y253	4.82	No	No	0	4	4
153	R:R:H187	R:R:V191	12.45	No	Yes	0	5	5
154	R:R:C188	R:R:I245	6.55	No	No	0	5	7
155	R:R:C188	R:R:I248	3.27	No	No	0	5	5
156	R:R:F189	R:R:L193	8.53	No	No	0	4	4
157	R:R:V191	R:R:W241	4.9	Yes	Yes	0	5	8
158	R:R:I245	R:R:V191	3.07	No	Yes	0	7	5
159	R:R:C196	R:R:Y192	8.06	No	No	0	6	7
160	R:R:A242	R:R:Y192	4	No	No	0	5	7
161	R:R:I245	R:R:Y192	4.84	No	No	0	7	7
162	R:R:P195	R:R:V194	3.53	No	No	0	9	5
163	R:R:F200	R:R:T234	9.08	No	No	0	5	8
164	R:R:I201	R:R:I205	2.94	No	No	0	5	5
165	R:R:L230	R:R:N203	8.24	Yes	No	2	8	9
166	R:R:N203	R:R:T234	4.39	No	No	0	9	8
167	R:R:I206	R:R:L230	2.85	No	Yes	0	8	8
168	R:R:T227	R:R:V207	7.93	Yes	No	6	8	6
169	R:R:F231	R:R:V207	11.8	No	No	6	6	6
170	R:R:R212	R:R:Y208	10.29	No	No	0	5	3
171	R:R:L210	R:R:T226	2.95	No	No	0	8	7
172	R:R:R211	R:R:R212	17.06	No	No	0	4	5
173	R:R:R217	R:R:S214	3.95	No	No	0	6	5
174	R:R:F216	R:R:L218	4.87	No	No	0	4	4
175	R:R:F216	R:R:R219	3.21	No	No	0	4	4
176	R:R:R219	R:R:S222	15.81	No	No	0	4	5
177	R:R:L230	R:R:T226	2.95	Yes	No	0	8	7
178	R:R:F231	R:R:T227	5.19	No	Yes	6	6	8
179	R:R:I229	R:R:I233	2.94	No	Yes	0	8	8
180	R:R:I229	R:R:I288	2.94	No	No	0	8	7
181	R:R:I233	R:R:L284	11.42	Yes	No	2	8	8
182	R:R:I233	R:R:Y285	7.25	Yes	Yes	2	8	9
183	R:R:I236	R:R:L240	4.28	No	No	0	6	8
184	R:R:I236	R:R:I280	2.94	No	No	0	6	6
185	R:R:I236	R:R:L284	4.28	No	No	0	6	8
186	R:R:F237	R:R:W241	6.01	No	Yes	1	9	8
187	R:R:F237	R:R:N277	7.25	No	No	1	9	9
188	R:R:L240	R:R:N277	12.36	No	No	0	8	9
189	R:R:R244	R:R:W241	6	No	Yes	1	5	8
190	R:R:A274	R:R:W241	6.48	No	Yes	0	7	8
191	R:R:N277	R:R:W241	9.04	No	Yes	1	9	8
192	R:R:A270	R:R:P243	3.74	No	No	0	6	8
193	R:R:L273	R:R:P243	6.57	No	No	0	8	8
194	R:R:N271	R:R:R244	12.05	No	No	1	6	5
195	L:L:?1	R:R:R244	27.68	Yes	No	1	0	5
196	R:R:I248	R:R:M247	2.92	No	Yes	1	5	4
197	R:R:M247	R:R:S267	7.67	Yes	No	0	4	4
198	L:L:?1	R:R:M247	5.37	Yes	Yes	1	0	4
199	L:L:?1	R:R:I248	8.67	Yes	No	1	0	5
200	L:L:?1	R:R:H251	9.76	Yes	No	1	0	4
201	R:R:L252	R:R:Y253	4.69	No	No	0	5	4
202	R:R:I257	R:R:N259	5.66	No	No	0	1	2
203	R:R:Q258	R:R:V263	5.73	No	No	1	1	3
204	R:R:L262	R:R:N259	8.24	No	No	0	3	2
205	R:R:H264	R:R:R260	11.28	No	No	0	3	1
206	R:R:I265	R:R:W261	3.52	No	No	0	3	2
207	R:R:D268	R:R:I265	4.2	No	No	0	5	3
208	L:L:?1	R:R:N271	11.47	Yes	No	1	0	6
209	R:R:L275	R:R:T278	4.42	No	No	0	6	8
210	L:L:?1	R:R:L275	3.15	Yes	No	0	0	6
211	R:R:N281	R:R:Y285	13.96	No	Yes	2	9	9
212	R:R:F282	R:R:F283	7.5	Yes	No	0	9	6
213	R:R:C286	R:R:F282	6.98	No	Yes	0	7	9
214	R:R:F283	R:R:F287	3.22	No	No	0	6	7
215	R:R:L284	R:R:Y285	4.69	No	Yes	2	8	9
216	R:R:C286	R:R:F292	4.19	No	No	0	7	9
217	R:R:R291	R:R:S289	9.22	No	No	0	7	9
218	R:R:K301	R:R:L300	5.64	No	No	0	4	5
219	R:R:F303	R:R:F304	6.43	No	No	0	2	2
220	R:R:I74	R:R:N44	2.83	No	No	0	7	9
221	R:R:D268	R:R:I269	2.8	No	No	0	5	5
222	R:R:H181	R:R:S178	2.79	No	No	0	2	1
223	R:R:P162	R:R:Y163	2.78	No	Yes	0	7	4
224	R:R:A43	R:R:F282	2.77	No	Yes	0	8	9
225	R:R:H181	R:R:V182	2.77	No	No	0	2	4
226	R:R:A238	R:R:F200	2.77	No	No	0	6	5
227	R:R:A296	R:R:F292	2.77	No	No	0	6	9
228	R:R:A143	R:R:Y141	2.67	No	No	0	4	8
229	R:R:C156	R:R:W117	2.61	No	No	0	7	7
230	R:R:V62	R:R:Y63	2.52	No	Yes	0	8	8
231	R:R:D268	R:R:H264	2.52	No	No	0	5	3
232	R:R:T145	R:R:Y65	2.5	No	Yes	0	8	8
233	R:R:F82	R:R:L87	2.44	No	No	0	7	4
234	R:R:L54	R:R:Y63	2.34	No	Yes	0	5	8
235	R:R:G40	R:R:P42	2.03	No	No	0	9	4
236	R:R:A242	R:R:P243	1.87	No	No	0	5	8
237	R:R:A255	R:R:P256	1.87	No	No	0	1	1
238	R:R:G224	R:R:T223	1.82	No	Yes	0	4	6
239	R:R:C156	R:R:S110	1.72	No	No	0	7	5
240	R:R:C196	R:R:S197	1.72	No	No	0	6	3
241	R:R:G40	R:R:L39	1.71	No	No	0	9	6
242	R:R:G40	R:R:L77	1.71	No	No	0	9	7
243	R:R:A72	R:R:S115	1.71	No	No	0	8	9
244	R:R:A70	R:R:V48	1.7	No	No	0	9	7
245	R:R:I104	R:R:P100	1.69	No	Yes	0	4	4
246	R:R:A72	R:R:T114	1.68	No	No	0	8	6
247	R:R:M96	R:R:P97	1.68	No	No	0	5	6
248	R:R:A302	R:R:T299	1.68	No	No	0	5	5
249	R:R:K102	R:R:P97	1.67	No	No	0	6	6
250	R:R:S160	R:R:V106	1.62	No	No	0	7	5
251	R:R:S140	R:R:V139	1.62	Yes	No	0	8	4
252	R:R:A242	R:R:I246	1.62	No	No	0	5	6
253	R:R:S222	R:R:T223	1.6	No	Yes	0	5	6
254	R:R:S235	R:R:T239	1.6	No	No	0	5	5
255	R:R:A297	R:R:L300	1.58	No	No	0	3	5
256	R:R:T223	R:R:T227	1.57	Yes	Yes	0	6	8
257	R:R:T226	R:R:T227	1.57	No	Yes	0	7	8
258	R:R:I205	R:R:S204	1.55	No	No	0	5	4
259	R:R:I104	R:R:V83	1.54	No	No	0	4	6
260	R:R:I154	R:R:V150	1.54	No	No	0	4	4
261	R:R:I186	R:R:V182	1.54	No	No	0	4	4
262	R:R:H132	R:R:P133	1.53	Yes	No	0	7	8
263	R:R:M272	R:R:V28	1.52	No	No	0	6	4
264	R:R:I233	R:R:T232	1.52	Yes	No	0	8	5
265	R:R:F27	R:R:G26	1.51	No	No	0	3	3
266	R:R:M295	R:R:T294	1.51	No	No	0	6	4
267	R:R:L67	R:R:S52	1.5	No	No	0	6	4
268	R:R:N215	R:R:S222	1.49	No	No	0	4	5
269	R:R:N259	R:R:V263	1.48	No	No	0	2	3
270	R:R:I45	R:R:I49	1.47	No	No	0	4	5
271	R:R:L240	R:R:T239	1.47	No	No	0	8	5
272	R:R:G254	R:R:Y253	1.45	No	No	0	3	4
273	R:R:M247	R:R:M266	1.44	Yes	No	0	4	4
274	R:R:I91	R:R:L87	1.43	No	No	0	3	4
275	R:R:I103	R:R:L107	1.43	No	No	0	4	5
276	R:R:I201	R:R:L202	1.43	No	Yes	0	5	7
277	R:R:P142	R:R:Y141	1.39	No	No	0	3	8
278	R:R:K102	R:R:Q98	1.36	No	No	0	6	4
279	R:R:A71	R:R:Y153	1.33	No	No	0	6	7
280	R:R:R58	R:R:V55	1.31	No	No	0	6	4
281	R:R:R144	R:R:V139	1.31	No	No	0	6	4
282	R:R:D89	R:R:E88	1.3	No	No	0	3	3
283	R:R:R211	R:R:T223	1.29	No	Yes	0	4	6
284	R:R:S176	R:R:Y174	1.27	No	Yes	0	3	6
285	R:R:M295	R:R:R291	1.24	No	No	0	6	7
286	R:R:F304	R:R:K301	1.24	No	No	0	2	4
287	R:R:L218	R:R:R217	1.21	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y32	8.8125	4	3	5
2	R:R:Y33	8.2075	4	3	7
3	R:R:Y63	4.512	5	0	8
4	R:R:Y65	4.82	4	0	8
5	R:R:L69	4.91	4	2	9
6	R:R:V81	3.9275	4	0	7
7	R:R:P100	6.1875	4	0	4
8	R:R:E108	6.7525	4	0	5
9	R:R:F109	10.2025	4	1	5
10	R:R:T119	4.4375	4	2	8
11	R:R:R126	4.8125	4	2	9
12	R:R:Y127	6.13	4	5	8
13	R:R:H132	4.838	5	5	7
14	R:R:Y136	7.4475	4	4	7
15	R:R:S140	4.27	4	4	8
16	R:R:Y163	5.27167	6	1	4
17	R:R:W166	8.40143	7	1	5
18	R:R:W170	7.716	5	1	2
19	R:R:Y174	6.0625	4	1	6
20	R:R:H180	12.5675	4	1	4
21	R:R:V191	5.8725	4	0	5
22	R:R:L202	3.86	4	0	7
23	R:R:T223	1.57	4	0	6
24	R:R:T227	4.065	4	6	8
25	R:R:L230	5.0275	4	2	8
26	R:R:I233	5.7825	4	2	8
27	R:R:W241	6.486	5	1	8
28	R:R:M247	4.35	4	1	4
29	R:R:F282	5.956	5	0	9
30	R:R:Y285	6.548	5	2	9
31	L:L:?1	9.88909	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D84	R:R:E88	10.5204	7.8	No	No	0	4	3
2	R:R:D84	R:R:E108	12.9391	11.69	No	Yes	0	4	5
3	L:L:?1	R:R:E108	36.2132	3.02	Yes	Yes	0	0	5
4	L:L:?1	R:R:L275	23.7126	3.15	Yes	No	0	0	6
5	R:R:D73	R:R:L69	40.8653	4.07	No	Yes	0	9	9
6	R:R:L69	R:R:T119	28.6541	4.42	Yes	Yes	2	9	8
7	R:R:T119	R:R:Y285	22.3292	3.75	Yes	Yes	2	8	9
8	R:R:L284	R:R:Y285	97.4818	4.69	No	Yes	2	8	9
9	R:R:I236	R:R:L284	100	4.28	No	No	0	6	8
10	R:R:I236	R:R:L240	99.8372	4.28	No	No	0	6	8
11	R:R:L240	R:R:N277	99.5253	12.36	No	No	0	8	9
12	R:R:N277	R:R:W241	98.6618	9.04	No	Yes	1	9	8
13	R:R:R244	R:R:W241	82.463	6	No	Yes	1	5	8
14	L:L:?1	R:R:R244	81.2559	27.68	Yes	No	1	0	5
15	R:R:L69	R:R:N281	21	6.87	Yes	No	2	9	9
16	R:R:N281	R:R:Y285	21.9766	13.96	No	Yes	2	9	9
17	R:R:D73	R:R:N44	39.0795	5.39	No	No	0	9	9
18	R:R:F282	R:R:N44	20.9639	6.04	Yes	No	0	9	9
19	R:R:I74	R:R:N44	17.2024	2.83	No	No	0	7	9
20	R:R:I45	R:R:I74	11.4653	2.94	No	No	0	4	7
21	R:R:R126	R:R:Y285	68.8006	3.09	Yes	Yes	2	9	9
22	R:R:R126	R:R:T123	47.0907	6.47	Yes	No	0	9	9
23	R:R:L202	R:R:T123	54.7222	2.95	Yes	No	0	7	9
24	R:R:I124	R:R:L202	51.5937	2.85	No	Yes	0	6	7
25	R:R:I124	R:R:P121	50.7482	3.39	No	No	0	6	7
26	R:R:P121	R:R:Y65	36.9818	6.95	No	Yes	0	7	8
27	R:R:L122	R:R:Y65	15.7557	3.52	No	Yes	0	8	8
28	R:R:L122	R:R:V62	14.5847	2.98	No	No	0	8	8
29	R:R:V62	R:R:Y63	13.4048	2.52	No	Yes	0	8	8
30	R:R:T145	R:R:Y65	19.2052	2.5	No	Yes	0	8	8
31	R:R:S61	R:R:T145	13.5494	4.8	No	No	0	7	8
32	R:R:S140	R:R:S61	12.3649	4.89	Yes	No	0	8	7
33	R:R:E108	R:R:I104	24.9514	5.47	Yes	No	0	5	4
34	R:R:I104	R:R:P100	22.7813	1.69	No	Yes	0	4	4
35	R:R:M96	R:R:P100	14.2683	6.71	No	Yes	0	5	4
36	R:R:M96	R:R:P97	13.016	1.68	No	No	0	5	6
37	R:R:K102	R:R:P97	10.4842	1.67	No	No	0	6	6
38	L:L:?1	R:R:W166	27.6233	3.46	Yes	Yes	1	0	5
39	R:R:C156	R:R:W117	12.383	2.61	No	No	0	7	7
40	R:R:V120	R:R:W117	14.752	7.36	No	No	0	8	7
41	R:R:P121	R:R:V120	17.0849	5.3	No	No	0	7	8
42	R:R:V191	R:R:W241	19.5533	4.9	Yes	Yes	0	5	8
43	R:R:L230	R:R:R126	27.4832	6.07	Yes	Yes	2	8	9
44	R:R:L202	R:R:Y127	13.0883	8.21	Yes	Yes	0	7	8
45	R:R:I206	R:R:Y127	11.0312	3.63	No	Yes	0	8	8
46	R:R:I206	R:R:L230	12.3695	2.85	No	Yes	0	8	8
47	R:R:I184	R:R:W166	15.498	3.52	No	Yes	0	4	5
48	L:L:?1	R:R:I169	15.3533	20.6	Yes	No	1	0	4
49	R:R:I169	R:R:W170	14.856	9.4	No	Yes	1	4	2
50	R:R:I184	R:R:L252	14.4175	4.28	No	No	0	4	5
51	R:R:I245	R:R:Y192	11.3161	4.84	No	No	0	7	7
52	R:R:L230	R:R:T226	24.3682	2.95	Yes	No	0	8	7
53	R:R:T226	R:R:T227	21.7912	1.57	No	Yes	0	7	8
54	R:R:T223	R:R:T227	17.5867	1.57	Yes	Yes	0	6	8
55	R:R:S222	R:R:T223	10.3667	1.6	No	Yes	0	5	6
56	R:R:L275	R:R:V81	15.3714	2.98	No	Yes	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I80	R:R:V76	3.07	1	No	No	6	7	2	2
R:R:I112	R:R:V76	3.07	1	No	No	6	7	1	2
R:R:E108	R:R:I80	6.83	0	Yes	No	5	6	1	2
R:R:I112	R:R:I80	2.94	1	No	No	6	6	1	2
R:R:L275	R:R:V81	2.98	0	No	Yes	6	7	1	2
R:R:D84	R:R:E108	11.69	0	No	Yes	4	5	2	1
R:R:E108	R:R:I104	5.47	0	Yes	No	5	4	1	2
R:R:E105	R:R:W166	13.08	0	No	Yes	4	5	2	1
L:L:?1	R:R:E108	3.02	1	Yes	Yes	0	5	0	1
R:R:F109	R:R:H113	3.39	1	Yes	No	5	6	1	2
R:R:F109	R:R:Y163	6.19	1	Yes	Yes	5	4	1	2
R:R:F109	R:R:W166	21.05	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:F109	10.18	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I112	5.42	1	Yes	No	0	6	0	1
R:R:H113	R:R:Y163	7.62	1	No	Yes	6	4	2	2
R:R:W166	R:R:Y163	4.82	1	Yes	Yes	5	4	1	2
R:R:L183	R:R:Y163	5.86	1	No	Yes	5	4	2	2
R:R:P167	R:R:W166	9.46	1	No	Yes	4	5	2	1
R:R:L183	R:R:W166	3.42	1	No	Yes	5	5	2	1
R:R:I184	R:R:W166	3.52	0	No	Yes	4	5	2	1
L:L:?1	R:R:W166	3.46	1	Yes	Yes	0	5	0	1
R:R:P167	R:R:Y174	5.56	1	No	Yes	4	6	2	2
R:R:I169	R:R:W170	9.4	1	No	Yes	4	2	1	2
R:R:H251	R:R:I169	6.63	1	No	No	4	4	1	1
L:L:?1	R:R:I169	20.6	1	Yes	No	0	4	0	1
R:R:S267	R:R:W170	3.71	0	No	Yes	4	2	2	2
R:R:H251	R:R:Y174	11.98	1	No	Yes	4	6	1	2
R:R:C188	R:R:I248	3.27	0	No	No	5	5	2	1
R:R:R244	R:R:W241	6	1	No	Yes	5	8	1	2
R:R:N271	R:R:R244	12.05	1	No	No	6	5	1	1
L:L:?1	R:R:R244	27.68	1	Yes	No	0	5	0	1
R:R:I248	R:R:M247	2.92	1	No	Yes	5	4	1	1
R:R:M247	R:R:S267	7.67	1	Yes	No	4	4	1	2
L:L:?1	R:R:M247	5.37	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I248	8.67	1	Yes	No	0	5	0	1
L:L:?1	R:R:H251	9.76	1	Yes	No	0	4	0	1
L:L:?1	R:R:N271	11.47	1	Yes	No	0	6	0	1
R:R:L275	R:R:T278	4.42	0	No	No	6	8	1	2
L:L:?1	R:R:L275	3.15	1	Yes	No	0	6	0	1
R:R:M247	R:R:M266	1.44	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VUJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	260
Number of Links	287
Number of Hubs	31
Number of Links mediated by Hubs	122
Number of Communities	6
Number of Nodes involved in Communities	48
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	40601
Length Of Smallest Path	3
Average Path Length	14.3674
Length of Longest Path	32
Minimum Path Strength	1.375
Average Path Strength	6.12771
Maximum Path Strength	20.34
Minimum Path Correlation	0.7
Average Path Correlation	0.929727
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	45.2499
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.2779
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • identical protein binding • protein binding • binding • xylanase activity • hydrolase activity, acting on glycosyl bonds • endo-1,4-beta-xylanase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • hydrolase activity • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • carbohydrate metabolic process • xylan catabolic process • catabolic process • hemicellulose metabolic process • cell wall organization or biogenesis • carbohydrate catabolic process • hemicellulose catabolic process • primary metabolic process • macromolecule catabolic process • cell wall macromolecule catabolic process • xylan metabolic process • polysaccharide metabolic process • polysaccharide catabolic process • metabolic process • macromolecule metabolic process • cell wall polysaccharide metabolic process • cell wall macromolecule metabolic process • cell wall polysaccharide catabolic process • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7ZQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7ZQ
Name	3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Synonyms
Identifier
Formula	C17 H17 Cl N2 O2
Molecular Weight	316.782
SMILES
PubChem	2548547
Formal Charge	0
Total Atoms	39
Total Chiral Atoms	1
Total Bonds	40
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6DWJ6
Sequence	>7VUJ_nogp_Chain_R G F V P V V Y Y S L L L C L G L P A N I L T V I I L S Q L V A R R Q K S V Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L N M Q M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H P L K Y H T V S Y P A R T R K V I V S V Y I T C F L T S I P Y Y W W P N I W T E D Y I S T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K S N F R L R G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G A P I Q N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R F R T M A A A T L K A F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VUJ	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP	chim(Gs-CtGq)/β1/γ2	3.8	2021-12-29	10.1038/s41422-021-00591-w
	7VUJ (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP		3.8	2021-12-29	10.1038/s41422-021-00591-w
	7VUI	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP	chim(Gs-CtGq)/β1/γ2	3.3	2021-12-29	10.1038/s41422-021-00591-w
	7VUI (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP		3.3	2021-12-29	10.1038/s41422-021-00591-w
	7VUH	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	chim(Gs-CtGq)/β1/γ2	3.22	2021-12-29	10.1038/s41422-021-00591-w
	7VUH (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.22	2021-12-29	10.1038/s41422-021-00591-w
	7VUG	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	Gi1/β1/γ2	3.2	2021-12-29	10.1038/s41422-021-00591-w
	7VUG (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.2	2021-12-29	10.1038/s41422-021-00591-w

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