psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I265	R:R:L25	8.56	No	No	0	3	3
2	R:R:G26	R:R:P29	4.06	No	Yes	0	3	5
3	R:R:P29	R:R:V28	3.53	Yes	No	0	5	4
4	R:R:D268	R:R:P29	4.83	No	Yes	0	5	5
5	R:R:F90	R:R:V30	3.93	No	No	0	4	4
6	R:R:M272	R:R:Y32	9.58	No	No	0	6	5
7	R:R:L276	R:R:Y32	4.69	No	No	0	6	5
8	R:R:V81	R:R:Y33	5.05	Yes	Yes	1	7	7
9	R:R:F85	R:R:Y33	22.69	No	Yes	1	5	7
10	R:R:M272	R:R:Y33	4.79	No	Yes	0	6	7
11	R:R:L275	R:R:Y33	5.86	Yes	Yes	1	6	7
12	R:R:L36	R:R:L77	4.15	No	Yes	0	7	7
13	R:R:L37	R:R:L41	4.15	Yes	No	1	7	7
14	R:R:L37	R:R:L77	4.15	Yes	Yes	1	7	7
15	R:R:L37	R:R:V81	5.96	Yes	Yes	1	7	7
16	R:R:F82	R:R:L37	3.65	No	Yes	0	7	7
17	R:R:L41	R:R:L77	8.3	No	Yes	1	7	7
18	R:R:A43	R:R:F282	6.93	No	Yes	0	8	9
19	R:R:D73	R:R:N44	12.12	No	No	0	9	9
20	R:R:F282	R:R:N44	4.83	Yes	No	0	9	9
21	R:R:I50	R:R:L46	7.14	Yes	No	0	8	6
22	R:R:F282	R:R:T47	5.19	Yes	No	0	9	8
23	R:R:F292	R:R:I50	3.77	No	Yes	0	9	8
24	R:R:L51	R:R:L67	5.54	No	No	0	7	6
25	R:R:L54	R:R:Y63	10.55	No	Yes	0	5	8
26	R:R:N64	R:R:R57	7.23	No	No	0	5	7
27	R:R:K60	R:R:V62	4.55	No	No	0	7	8
28	R:R:K60	R:R:Y63	17.91	No	Yes	0	7	8
29	R:R:S61	R:R:Y65	8.9	No	Yes	2	7	8
30	R:R:S61	R:R:T145	9.59	No	No	2	7	8
31	R:R:R291	R:R:Y63	4.12	No	Yes	0	7	8
32	R:R:N64	R:R:T145	4.39	No	No	0	5	8
33	R:R:P121	R:R:Y65	6.95	No	Yes	2	7	8
34	R:R:L122	R:R:Y65	8.21	No	Yes	0	8	8
35	R:R:D125	R:R:Y65	8.05	No	Yes	2	9	8
36	R:R:T145	R:R:Y65	3.75	No	Yes	2	8	8
37	R:R:V148	R:R:Y65	5.05	No	Yes	2	6	8
38	R:R:A68	R:R:I118	4.87	No	No	0	8	7
39	R:R:I118	R:R:L69	5.71	No	No	0	7	9
40	R:R:L69	R:R:T119	4.42	No	No	3	9	8
41	R:R:L69	R:R:N281	5.49	No	No	3	9	9
42	R:R:D73	R:R:T278	4.34	No	No	0	9	8
43	R:R:S111	R:R:V76	4.85	No	No	0	7	7
44	R:R:T278	R:R:V76	4.76	No	No	0	8	7
45	R:R:L77	R:R:V81	4.47	Yes	Yes	1	7	7
46	R:R:F78	R:R:F79	4.29	No	No	0	5	4
47	R:R:F79	R:R:L107	6.09	No	No	0	4	5
48	R:R:D84	R:R:I80	5.6	No	Yes	1	4	6
49	R:R:F85	R:R:I80	3.77	No	Yes	1	5	6
50	R:R:E108	R:R:I80	12.3	No	Yes	1	5	6
51	L:L:?1	R:R:I80	8.67	Yes	Yes	1	0	6
52	R:R:L275	R:R:V81	4.47	Yes	Yes	1	6	7
53	R:R:F82	R:R:L87	7.31	No	No	0	7	4
54	R:R:I104	R:R:V83	6.14	No	No	0	4	6
55	R:R:D84	R:R:E88	6.5	No	No	0	4	3
56	R:R:D84	R:R:E108	11.69	No	No	1	4	5
57	R:R:F85	R:R:L275	3.65	No	Yes	1	5	6
58	R:R:I91	R:R:L87	4.28	No	No	0	3	4
59	R:R:E88	R:R:Q95	6.37	No	No	0	3	4
60	R:R:D89	R:R:F90	19.11	No	No	0	3	4
61	R:R:P100	R:R:Q95	6.32	No	No	0	4	4
62	R:R:D101	R:R:Q95	7.83	No	No	0	9	4
63	R:R:M96	R:R:P100	6.71	No	No	0	5	4
64	R:R:P97	R:R:Q98	11.05	No	No	0	6	4
65	R:R:D101	R:R:P97	4.83	No	No	0	9	6
66	R:R:P100	R:R:V99	3.53	No	No	0	4	1
67	R:R:K102	R:R:Y164	11.94	No	No	0	6	5
68	R:R:I103	R:R:Y164	4.84	No	No	0	4	5
69	R:R:I104	R:R:L107	5.71	No	No	0	4	5
70	R:R:E105	R:R:F109	4.66	No	Yes	1	4	5
71	R:R:E105	R:R:W166	8.72	No	Yes	1	4	5
72	R:R:F109	R:R:H113	4.53	Yes	Yes	1	5	6
73	R:R:F109	R:R:Y163	22.69	Yes	Yes	1	5	4
74	R:R:F109	R:R:W166	21.05	Yes	Yes	1	5	5
75	L:L:?1	R:R:F109	14.8	Yes	Yes	1	0	5
76	R:R:F157	R:R:S110	13.21	No	No	0	4	5
77	R:R:S110	R:R:S160	4.89	No	No	0	5	7
78	R:R:H113	R:R:I112	3.98	Yes	Yes	1	6	6
79	R:R:I112	R:R:S115	6.19	Yes	No	0	6	9
80	R:R:I112	R:R:W241	4.7	Yes	Yes	1	6	8
81	L:L:?1	R:R:I112	4.34	Yes	Yes	1	0	6
82	R:R:H113	R:R:Y163	8.71	Yes	Yes	1	6	4
83	R:R:H113	R:R:H187	10.75	Yes	Yes	1	6	5
84	R:R:H113	R:R:T190	6.85	Yes	No	0	6	4
85	R:R:T114	R:R:Y153	3.75	No	No	0	6	7
86	R:R:C156	R:R:T114	6.76	No	No	0	7	6
87	R:R:F237	R:R:I116	3.77	Yes	No	0	9	7
88	R:R:V120	R:R:W117	9.81	No	No	0	8	7
89	R:R:T190	R:R:W117	4.85	No	No	0	4	7
90	R:R:P195	R:R:W117	5.4	No	No	0	9	7
91	R:R:F199	R:R:T119	3.89	Yes	No	0	8	8
92	R:R:N281	R:R:T119	4.39	No	No	3	9	8
93	R:R:P121	R:R:V120	3.53	No	No	0	7	8
94	R:R:I198	R:R:V120	6.14	No	No	0	6	8
95	R:R:P121	R:R:V148	3.53	No	No	2	7	6
96	R:R:R126	R:R:T123	3.88	No	No	0	9	9
97	R:R:F199	R:R:T123	9.08	Yes	No	0	8	9
98	R:R:D125	R:R:Y136	8.05	No	Yes	2	9	7
99	R:R:D125	R:R:S140	5.89	No	No	2	9	8
100	R:R:C131	R:R:Y127	10.75	No	Yes	0	7	8
101	R:R:L202	R:R:Y127	12.89	No	Yes	0	7	8
102	R:R:I205	R:R:Y127	10.88	No	Yes	0	5	8
103	R:R:I206	R:R:Y127	8.46	No	Yes	0	8	8
104	R:R:I128	R:R:Y136	4.84	No	Yes	0	7	7
105	R:R:A129	R:R:Y136	8.01	No	Yes	0	8	7
106	R:R:C131	R:R:H132	7.37	No	No	0	7	7
107	R:R:H137	R:R:Y136	10.89	No	Yes	0	5	7
108	R:R:S140	R:R:Y136	8.9	No	Yes	2	8	7
109	R:R:R144	R:R:Y141	16.46	No	No	0	6	8
110	R:R:I149	R:R:R146	11.27	No	No	0	7	5
111	R:R:S160	R:R:Y163	5.09	No	Yes	0	7	4
112	R:R:L183	R:R:Y163	8.21	No	Yes	0	5	4
113	R:R:H187	R:R:Y163	7.62	Yes	Yes	1	5	4
114	R:R:V179	R:R:W165	12.26	No	No	0	4	5
115	R:R:P167	R:R:W166	10.81	No	Yes	0	4	5
116	R:R:L183	R:R:W166	4.56	No	Yes	0	5	5
117	R:R:R244	R:R:W166	4	Yes	Yes	1	5	5
118	L:L:?1	R:R:W166	18.17	Yes	Yes	1	0	5
119	R:R:P167	R:R:Y174	4.17	No	No	0	4	6
120	R:R:H180	R:R:P167	12.2	No	No	0	4	4
121	R:R:N168	R:R:T171	4.39	No	No	0	3	1
122	R:R:I169	R:R:W170	16.44	Yes	No	0	4	2
123	R:R:I169	R:R:Y174	9.67	Yes	No	0	4	6
124	R:R:H251	R:R:I169	5.3	No	Yes	1	4	4
125	L:L:?1	R:R:I169	10.84	Yes	Yes	1	0	4
126	R:R:V263	R:R:W170	6.13	No	No	0	3	2
127	R:R:H264	R:R:W170	13.75	No	No	0	3	2
128	R:R:S176	R:R:Y174	3.82	No	No	0	3	6
129	R:R:H181	R:R:S176	5.58	No	No	0	2	3
130	R:R:H180	R:R:T177	9.58	No	No	0	4	1
131	R:R:H180	R:R:V179	6.92	No	No	0	4	4
132	R:R:H181	R:R:L252	12.86	No	Yes	0	2	5
133	R:R:I184	R:R:L252	5.71	No	Yes	0	4	5
134	R:R:L249	R:R:W185	7.97	No	No	0	5	4
135	R:R:L252	R:R:W185	5.69	Yes	No	0	5	4
136	R:R:H187	R:R:V191	9.69	Yes	No	0	5	5
137	R:R:H187	R:R:R244	9.03	Yes	Yes	1	5	5
138	R:R:C188	R:R:I245	6.55	No	No	0	5	7
139	R:R:C188	R:R:L249	4.76	No	No	0	5	5
140	R:R:F189	R:R:L193	7.31	No	No	0	4	4
141	R:R:V191	R:R:W241	11.03	No	Yes	0	5	8
142	R:R:C196	R:R:Y192	8.06	No	Yes	0	6	7
143	R:R:A238	R:R:Y192	4	No	Yes	0	6	7
144	R:R:A242	R:R:Y192	4	No	Yes	0	5	7
145	R:R:I245	R:R:Y192	6.04	No	Yes	0	7	7
146	R:R:P195	R:R:V194	3.53	No	No	0	9	5
147	R:R:F199	R:R:T234	9.08	Yes	No	0	8	8
148	R:R:F199	R:R:F237	5.36	Yes	Yes	0	8	9
149	R:R:F200	R:R:T234	10.38	No	No	0	5	8
150	R:R:L230	R:R:N203	9.61	No	No	0	8	9
151	R:R:N203	R:R:T234	5.85	No	No	0	9	8
152	R:R:I206	R:R:L230	8.56	No	No	0	8	8
153	R:R:T227	R:R:V207	9.52	No	No	0	8	6
154	R:R:R212	R:R:Y208	13.38	No	No	0	5	3
155	R:R:K209	R:R:K213	4.31	No	No	0	5	6
156	R:R:R211	R:R:R212	10.66	No	No	0	4	5
157	R:R:R217	R:R:S214	3.95	No	No	0	6	5
158	R:R:N215	R:R:R219	6.03	No	No	0	4	4
159	R:R:F216	R:R:L218	8.53	No	No	0	4	4
160	R:R:R219	R:R:S222	9.22	No	No	0	4	5
161	R:R:G224	R:R:T223	3.64	No	Yes	0	4	6
162	R:R:F231	R:R:S235	3.96	No	No	0	6	5
163	R:R:I233	R:R:L284	4.28	No	No	0	8	8
164	R:R:I233	R:R:Y285	3.63	No	No	0	8	9
165	R:R:I236	R:R:L240	4.28	No	Yes	0	6	8
166	R:R:I236	R:R:I280	5.89	No	No	0	6	6
167	R:R:F237	R:R:W241	7.02	Yes	Yes	1	9	8
168	R:R:F237	R:R:N277	8.46	Yes	No	1	9	9
169	R:R:L240	R:R:L273	4.15	Yes	No	0	8	8
170	R:R:L240	R:R:L276	4.15	Yes	No	0	8	6
171	R:R:L240	R:R:N277	4.12	Yes	No	0	8	9
172	R:R:R244	R:R:W241	5	Yes	Yes	1	5	8
173	R:R:A274	R:R:W241	9.08	No	Yes	0	7	8
174	R:R:N277	R:R:W241	7.91	No	Yes	1	9	8
175	L:L:?1	R:R:W241	4.33	Yes	Yes	1	0	8
176	R:R:A270	R:R:P243	3.74	No	No	0	6	8
177	R:R:L273	R:R:P243	4.93	No	No	0	8	8
178	R:R:I248	R:R:R244	3.76	No	Yes	1	5	5
179	R:R:N271	R:R:R244	9.64	No	Yes	1	6	5
180	L:L:?1	R:R:R244	27.68	Yes	Yes	1	0	5
181	R:R:M247	R:R:V263	4.56	No	No	0	4	3
182	R:R:M247	R:R:M266	4.33	No	No	0	4	4
183	L:L:?1	R:R:I248	4.34	Yes	No	1	0	5
184	R:R:G254	R:R:Y250	4.35	No	No	0	3	4
185	R:R:A255	R:R:Y250	4	No	No	0	1	4
186	R:R:H251	R:R:N259	3.83	No	No	0	4	2
187	L:L:?1	R:R:H251	11.72	Yes	No	1	0	4
188	R:R:A255	R:R:N259	4.69	No	No	0	1	2
189	R:R:R260	R:R:W261	7	No	No	0	1	2
190	L:L:?1	R:R:S267	6.84	Yes	No	0	0	4
191	L:L:?1	R:R:N271	10.43	Yes	No	1	0	6
192	L:L:?1	R:R:L275	7.36	Yes	Yes	1	0	6
193	R:R:F283	R:R:I280	3.77	No	No	0	6	6
194	R:R:I280	R:R:L284	4.28	No	No	0	6	8
195	R:R:N281	R:R:Y285	9.3	No	No	0	9	9
196	R:R:F282	R:R:F283	5.36	Yes	No	0	9	6
197	R:R:C286	R:R:F282	6.98	No	Yes	0	7	9
198	R:R:F283	R:R:F287	4.29	No	No	0	6	7
199	R:R:C286	R:R:F292	11.17	No	No	0	7	9
200	R:R:F287	R:R:R293	5.34	No	No	0	7	9
201	R:R:R291	R:R:S289	6.59	No	No	0	7	9
202	R:R:K290	R:R:R293	6.19	No	No	0	5	9
203	R:R:F304	R:R:K301	6.2	No	No	0	2	4
204	R:R:F303	R:R:F304	5.36	No	No	0	2	2
205	R:R:L51	R:R:Y63	3.52	No	Yes	0	7	8
206	R:R:L66	R:R:Y285	3.52	No	No	0	9	9
207	R:R:E108	R:R:F79	3.5	No	No	0	5	4
208	R:R:C156	R:R:S110	3.44	No	No	0	7	5
209	R:R:I161	R:R:P162	3.39	No	No	0	5	7
210	R:R:I257	R:R:P256	3.39	No	No	0	1	1
211	R:R:A70	R:R:T47	3.36	No	No	0	9	8
212	R:R:A72	R:R:T114	3.36	No	No	0	8	6
213	R:R:A68	R:R:I149	3.25	No	No	0	8	7
214	R:R:C131	R:R:K209	3.23	No	No	0	7	5
215	R:R:S197	R:R:V194	3.23	No	No	0	3	5
216	R:R:T138	R:R:V139	3.17	No	No	0	4	4
217	R:R:T155	R:R:T159	3.14	No	No	0	3	4
218	R:R:T223	R:R:T227	3.14	Yes	No	0	6	8
219	R:R:I118	R:R:V152	3.07	No	No	0	7	7
220	R:R:I206	R:R:V130	3.07	No	No	0	8	8
221	R:R:I50	R:R:T299	3.04	Yes	No	0	8	5
222	R:R:I236	R:R:T239	3.04	No	No	0	6	5
223	R:R:M295	R:R:T294	3.01	No	No	0	6	4
224	R:R:L35	R:R:V31	2.98	No	No	0	4	6
225	R:R:L210	R:R:V130	2.98	No	No	0	8	8
226	R:R:I201	R:R:I205	2.94	No	No	0	5	5
227	R:R:I229	R:R:I233	2.94	No	No	0	8	8
228	R:R:W165	R:R:Y164	2.89	No	No	0	5	5
229	R:R:I91	R:R:L92	2.85	No	No	0	3	3
230	R:R:I124	R:R:L202	2.85	No	No	0	6	7
231	R:R:I74	R:R:N44	2.83	No	No	0	7	9
232	R:R:L262	R:R:M266	2.83	No	No	0	3	4
233	R:R:K301	R:R:L300	2.82	No	No	0	4	5
234	R:R:P29	R:R:Y33	2.78	Yes	Yes	0	5	7
235	R:R:L37	R:R:L86	2.77	Yes	No	0	7	4
236	R:R:D101	R:R:N168	2.69	No	No	0	9	3
237	R:R:A56	R:R:Y63	2.67	No	Yes	0	7	8
238	R:R:A143	R:R:Y141	2.67	No	No	0	4	8
239	R:R:F292	R:R:S289	2.64	No	No	0	9	9
240	R:R:R58	R:R:V55	2.62	No	No	0	6	4
241	R:R:R211	R:R:T223	2.59	No	Yes	0	4	6
242	R:R:F157	R:R:L75	2.44	No	No	0	4	6
243	R:R:I186	R:R:Y163	2.42	No	Yes	0	4	4
244	R:R:L249	R:R:Y253	2.34	No	No	0	5	4
245	R:R:L252	R:R:Y253	2.34	Yes	No	0	5	4
246	R:R:F216	R:R:R219	2.14	No	No	0	4	4
247	R:R:R57	R:R:R58	2.13	No	No	0	7	6
248	R:R:G40	R:R:P42	2.03	No	No	0	9	4
249	R:R:A43	R:R:G40	1.95	No	No	0	8	9
250	R:R:A228	R:R:G224	1.95	No	No	0	5	4
251	R:R:A255	R:R:P256	1.87	No	No	0	1	1
252	R:R:G26	R:R:L25	1.71	No	No	0	3	3
253	R:R:A70	R:R:V48	1.7	No	No	0	9	7
254	R:R:C156	R:R:T155	1.69	No	No	0	7	3
255	R:R:A302	R:R:T299	1.68	No	No	0	5	5
256	R:R:L183	R:R:P162	1.64	No	No	0	5	7
257	R:R:N64	R:R:P142	1.63	No	No	0	5	3
258	R:R:S52	R:R:V48	1.62	No	No	0	4	7
259	R:R:A296	R:R:I50	1.62	No	Yes	0	6	8
260	R:R:S151	R:R:V148	1.62	No	No	0	4	6
261	R:R:S151	R:R:V152	1.62	No	No	0	4	7
262	R:R:S222	R:R:T223	1.6	No	Yes	0	5	6
263	R:R:C23	R:R:L25	1.59	No	No	0	4	3
264	R:R:A279	R:R:L36	1.58	No	No	0	7	7
265	R:R:I205	R:R:S204	1.55	No	No	0	5	4
266	R:R:I161	R:R:V106	1.54	No	No	0	5	5
267	R:R:I128	R:R:V139	1.54	No	No	0	7	4
268	R:R:I149	R:R:V150	1.54	No	No	0	7	4
269	R:R:I186	R:R:V182	1.54	No	No	0	4	4
270	R:R:H132	R:R:P133	1.53	No	No	0	7	8
271	R:R:K147	R:R:S151	1.53	No	No	0	3	4
272	R:R:F27	R:R:G24	1.51	No	No	0	3	2
273	R:R:F90	R:R:G26	1.51	No	No	0	4	3
274	R:R:L86	R:R:S34	1.5	No	No	0	4	5
275	R:R:L230	R:R:V207	1.49	No	No	0	8	6
276	R:R:I45	R:R:I49	1.47	No	No	0	4	5
277	R:R:I45	R:R:I74	1.47	No	No	0	4	7
278	R:R:L158	R:R:T159	1.47	No	No	0	4	4
279	R:R:L210	R:R:T226	1.47	No	No	0	8	7
280	R:R:I229	R:R:I288	1.47	No	No	0	8	7
281	R:R:I265	R:R:I269	1.47	No	No	0	3	5
282	R:R:I229	R:R:K225	1.45	No	No	0	8	7
283	R:R:E172	R:R:T171	1.41	No	No	0	4	1
284	R:R:P142	R:R:Y141	1.39	No	No	0	3	8
285	R:R:I49	R:R:Q53	1.37	No	No	0	5	5
286	R:R:A71	R:R:Y153	1.33	No	No	0	6	7
287	R:R:F189	R:R:V194	1.31	No	No	0	4	5
288	R:R:R291	R:R:T294	1.29	No	No	0	7	4
289	R:R:N215	R:R:R217	1.21	No	No	0	4	6
290	R:R:L218	R:R:R217	1.21	No	No	0	4	6
291	R:R:N259	R:R:R260	1.21	No	No	0	2	1
292	R:R:Q59	R:R:R58	1.17	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P29	3.8	4	0	5
2	R:R:Y33	8.234	5	1	7
3	R:R:L37	4.136	5	1	7
4	R:R:I50	3.8925	4	0	8
5	R:R:Y63	7.754	5	0	8
6	R:R:Y65	6.81833	6	2	8
7	R:R:L77	5.2675	4	1	7
8	R:R:I80	7.585	4	1	6
9	R:R:V81	4.9875	4	1	7
10	R:R:F109	13.546	5	1	5
11	R:R:I112	4.8025	4	1	6
12	R:R:H113	6.964	5	1	6
13	R:R:Y127	10.745	4	0	8
14	R:R:Y136	8.138	5	2	7
15	R:R:Y163	9.12333	6	1	4
16	R:R:W166	11.2183	6	1	5
17	R:R:I169	10.5625	4	1	4
18	R:R:H187	9.2725	4	1	5
19	R:R:Y192	5.525	4	0	7
20	R:R:F199	6.8525	4	0	8
21	R:R:T223	2.7425	4	0	6
22	R:R:F237	6.1525	4	1	9
23	R:R:L240	4.175	4	0	8
24	R:R:W241	7.01	7	1	8
25	R:R:R244	9.85167	6	1	5
26	R:R:L252	6.65	4	0	5
27	R:R:L275	5.335	4	1	6
28	R:R:F282	5.858	5	0	9
29	L:L:?1	10.7933	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G26	R:R:P29	18.6456	4.06	No	Yes	0	3	5
2	R:R:P29	R:R:Y33	25.233	2.78	Yes	Yes	0	5	7
3	R:R:M272	R:R:Y33	14.4039	4.79	No	Yes	0	6	7
4	R:R:M272	R:R:Y32	13.3114	9.58	No	No	0	6	5
5	R:R:L276	R:R:Y32	12.9017	4.69	No	No	0	6	5
6	R:R:L77	R:R:V81	12.3313	4.47	Yes	Yes	1	7	7
7	R:R:L37	R:R:V81	24.6706	5.96	Yes	Yes	1	7	7
8	R:R:F82	R:R:L37	12.5562	3.65	No	Yes	0	7	7
9	R:R:F282	R:R:F283	85.829	5.36	Yes	No	0	9	6
10	R:R:F283	R:R:I280	94.473	3.77	No	No	0	6	6
11	R:R:I236	R:R:I280	92.6253	5.89	No	No	0	6	6
12	R:R:I236	R:R:L240	96.401	4.28	No	Yes	0	6	8
13	R:R:L240	R:R:L276	14.9181	4.15	Yes	No	0	8	6
14	R:R:D73	R:R:N44	10.8853	12.12	No	No	0	9	9
15	R:R:F282	R:R:N44	24.1404	4.83	Yes	No	0	9	9
16	R:R:C286	R:R:F282	46.2243	6.98	No	Yes	0	7	9
17	R:R:C286	R:R:F292	43.75	11.17	No	No	0	7	9
18	R:R:F292	R:R:I50	13.0222	3.77	No	Yes	0	9	8
19	R:R:F282	R:R:T47	10.8853	5.19	Yes	No	0	9	8
20	R:R:F292	R:R:S289	29.0649	2.64	No	No	0	9	9
21	R:R:R291	R:R:S289	26.4782	6.59	No	No	0	7	9
22	R:R:R291	R:R:Y63	18.6215	4.12	No	Yes	0	7	8
23	R:R:L275	R:R:Y33	21.7304	5.86	Yes	Yes	1	6	7
24	L:L:?1	R:R:L275	54.3782	7.36	Yes	Yes	1	0	6
25	L:L:?1	R:R:F109	51.3255	14.8	Yes	Yes	1	0	5
26	R:R:F109	R:R:H113	33.9974	4.53	Yes	Yes	1	5	6
27	R:R:H113	R:R:T190	74.6465	6.85	Yes	No	0	6	4
28	R:R:T190	R:R:W117	72.2044	4.85	No	No	0	4	7
29	R:R:V120	R:R:W117	57.6478	9.81	No	No	0	8	7
30	R:R:P121	R:R:V120	52.892	3.53	No	No	0	7	8
31	R:R:P121	R:R:Y65	43.6777	6.95	No	Yes	2	7	8
32	R:R:T145	R:R:Y65	29.4344	3.75	No	Yes	2	8	8
33	R:R:N64	R:R:T145	26.8718	4.39	No	No	0	5	8
34	L:L:?1	R:R:I112	26.5424	4.34	Yes	Yes	1	0	6
35	R:R:H113	R:R:I112	49.5823	3.98	Yes	Yes	1	6	6
36	R:R:N64	R:R:R57	12.1064	7.23	No	No	0	5	7
37	R:R:D125	R:R:Y65	23.8994	8.05	No	Yes	2	9	8
38	R:R:A68	R:R:I118	10.4997	4.87	No	No	0	8	7
39	R:R:I118	R:R:L69	33.7002	5.71	No	No	0	7	9
40	R:R:L69	R:R:T119	22.7747	4.42	No	No	3	9	8
41	R:R:F199	R:R:T119	37.6928	3.89	Yes	No	0	8	8
42	R:R:F199	R:R:F237	99.1404	5.36	Yes	Yes	0	8	9
43	R:R:F237	R:R:W241	85.7808	7.02	Yes	Yes	1	9	8
44	L:L:?1	R:R:W241	100	4.33	Yes	Yes	1	0	8
45	R:R:N281	R:R:T119	13.5925	4.39	No	No	3	9	8
46	R:R:E108	R:R:F79	13.2069	3.5	No	No	0	5	4
47	R:R:E108	R:R:I80	15.2233	12.3	No	Yes	1	5	6
48	R:R:D84	R:R:I80	30.2458	5.6	No	Yes	1	4	6
49	R:R:D84	R:R:E88	28.3178	6.5	No	No	0	4	3
50	R:R:E88	R:R:Q95	25.8033	6.37	No	No	0	3	4
51	R:R:D101	R:R:Q95	15.5848	7.83	No	No	0	9	4
52	L:L:?1	R:R:W166	19.2963	18.17	Yes	Yes	1	0	5
53	R:R:P167	R:R:W166	35.6764	10.81	No	Yes	0	4	5
54	R:R:H180	R:R:P167	22.4293	12.2	No	No	0	4	4
55	R:R:H180	R:R:V179	16.099	6.92	No	No	0	4	4
56	R:R:V179	R:R:W165	12.9097	12.26	No	No	0	4	5
57	R:R:F157	R:R:S110	10.339	13.21	No	No	0	4	5
58	R:R:S110	R:R:S160	56.1054	4.89	No	No	0	5	7
59	R:R:S160	R:R:Y163	61.1102	5.09	No	Yes	0	7	4
60	R:R:F109	R:R:Y163	27.3779	22.69	Yes	Yes	1	5	4
61	R:R:H187	R:R:R244	16.1231	9.03	Yes	Yes	1	5	5
62	R:R:C156	R:R:S110	40.9945	3.44	No	No	0	7	5
63	R:R:C156	R:R:T114	20.6218	6.76	No	No	0	7	6
64	R:R:T114	R:R:Y153	10.339	3.75	No	No	0	6	7
65	R:R:P195	R:R:W117	15.4563	5.4	No	No	0	9	7
66	R:R:D125	R:R:Y136	18.019	8.05	No	Yes	2	9	7
67	R:R:C131	R:R:Y127	12.9981	10.75	No	Yes	0	7	8
68	R:R:I206	R:R:Y127	28.0929	8.46	No	Yes	0	8	8
69	R:R:I206	R:R:L230	37.267	8.56	No	No	0	8	8
70	R:R:L230	R:R:N203	73.1362	9.61	No	No	0	8	9
71	R:R:N203	R:R:T234	75.2892	5.85	No	No	0	9	8
72	R:R:F199	R:R:T234	79.5469	9.08	Yes	No	0	8	8
73	R:R:N64	R:R:P142	12.1064	1.63	No	No	0	5	3
74	L:L:?1	R:R:I169	56.74	10.84	Yes	Yes	1	0	4
75	R:R:I169	R:R:Y174	46.7384	9.67	Yes	No	0	4	6
76	R:R:I169	R:R:W170	13.7291	16.44	Yes	No	0	4	2
77	R:R:S176	R:R:Y174	56.8686	3.82	No	No	0	3	6
78	R:R:H181	R:R:S176	54.1774	5.58	No	No	0	2	3
79	R:R:H181	R:R:L252	51.4701	12.86	No	Yes	0	2	5
80	R:R:L252	R:R:W185	22.9997	5.69	Yes	No	0	5	4
81	R:R:L249	R:R:W185	20.188	7.97	No	No	0	5	4
82	R:R:L252	R:R:Y253	23.0077	2.34	Yes	No	0	5	4
83	R:R:L249	R:R:Y253	20.188	2.34	No	No	0	5	4
84	R:R:V191	R:R:W241	15.6652	11.03	No	Yes	0	5	8
85	R:R:C188	R:R:L249	34.6481	4.76	No	No	0	5	5
86	R:R:C188	R:R:I245	28.9123	6.55	No	No	0	5	7
87	R:R:P195	R:R:V194	12.3956	3.53	No	No	0	9	5
88	R:R:I245	R:R:Y192	23.1603	6.04	No	Yes	0	7	7
89	R:R:L230	R:R:V207	37.5402	1.49	No	No	0	8	6
90	R:R:T227	R:R:V207	35.1462	9.52	No	No	0	8	6
91	R:R:T223	R:R:T227	32.7201	3.14	Yes	No	0	6	8
92	R:R:S222	R:R:T223	17.8181	1.6	No	Yes	0	5	6
93	R:R:R219	R:R:S222	15.2796	9.22	No	No	0	4	5
94	R:R:I233	R:R:L284	20.8387	4.28	No	No	0	8	8
95	R:R:I280	R:R:L284	22.3409	4.28	No	No	0	6	8
96	R:R:N281	R:R:Y285	24.6465	9.3	No	No	0	9	9
97	R:R:N277	R:R:W241	80.6154	7.91	No	Yes	1	9	8
98	R:R:A255	R:R:N259	12.4438	4.69	No	No	0	1	2
99	R:R:H251	R:R:N259	19.722	3.83	No	No	0	4	2
100	L:L:?1	R:R:H251	19.2641	11.72	Yes	No	1	0	4
101	R:R:L183	R:R:W166	13.7452	4.56	No	Yes	0	5	5
102	R:R:C156	R:R:T155	15.4884	1.69	No	No	0	7	3
103	R:R:T155	R:R:T159	10.339	3.14	No	No	0	3	4
104	R:R:I118	R:R:V152	23.4174	3.07	No	No	0	7	7
105	R:R:I229	R:R:I233	12.7249	2.94	No	No	0	8	8
106	R:R:I74	R:R:N44	10.8853	2.83	No	No	0	7	9
107	R:R:S151	R:R:V148	23.0639	1.62	No	No	0	4	6
108	R:R:S151	R:R:V152	21.9875	1.62	No	No	0	4	7
109	R:R:I186	R:R:Y163	10.0739	2.42	No	Yes	0	4	4
110	R:R:F237	R:R:N277	16.5006	8.46	Yes	No	1	9	9
111	R:R:L240	R:R:N277	95.3567	4.12	Yes	No	0	8	9
112	R:R:I233	R:R:Y285	21.0315	3.63	No	No	0	8	9
113	R:R:I112	R:R:W241	25.5141	4.7	Yes	Yes	1	6	8
114	R:R:H187	R:R:V191	14.412	9.69	Yes	No	0	5	5
115	R:R:R244	R:R:W241	28.7275	5	Yes	Yes	1	5	8
116	L:L:?1	R:R:I80	43.2037	8.67	Yes	Yes	1	0	6
117	R:R:R244	R:R:W166	12.982	4	Yes	Yes	1	5	5
118	R:R:H113	R:R:Y163	18.6616	8.71	Yes	Yes	1	6	4
119	R:R:H187	R:R:Y163	26.5906	7.62	Yes	Yes	1	5	4
120	R:R:L275	R:R:V81	31.009	4.47	Yes	Yes	1	6	7
121	R:R:L69	R:R:N281	12.9418	5.49	No	No	3	9	9
122	R:R:V148	R:R:Y65	16.4685	5.05	No	Yes	2	6	8
123	R:R:F109	R:R:W166	12.2751	21.05	Yes	Yes	1	5	5
124	R:R:P167	R:R:Y174	14.8538	4.17	No	No	0	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V81	R:R:Y33	5.05	1	Yes	Yes	7	7	2	2
R:R:F85	R:R:Y33	22.69	1	No	Yes	5	7	2	2
R:R:L275	R:R:Y33	5.86	1	Yes	Yes	6	7	1	2
R:R:D84	R:R:I80	5.6	1	No	Yes	4	6	2	1
R:R:F85	R:R:I80	3.77	1	No	Yes	5	6	2	1
R:R:E108	R:R:I80	12.3	1	No	Yes	5	6	2	1
L:L:?1	R:R:I80	8.67	1	Yes	Yes	0	6	0	1
R:R:L275	R:R:V81	4.47	1	Yes	Yes	6	7	1	2
R:R:D84	R:R:E108	11.69	1	No	No	4	5	2	2
R:R:F85	R:R:L275	3.65	1	No	Yes	5	6	2	1
R:R:E105	R:R:F109	4.66	1	No	Yes	4	5	2	1
R:R:E105	R:R:W166	8.72	1	No	Yes	4	5	2	1
R:R:F109	R:R:H113	4.53	1	Yes	Yes	5	6	1	2
R:R:F109	R:R:Y163	22.69	1	Yes	Yes	5	4	1	2
R:R:F109	R:R:W166	21.05	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:F109	14.8	1	Yes	Yes	0	5	0	1
R:R:H113	R:R:I112	3.98	1	Yes	Yes	6	6	2	1
R:R:I112	R:R:S115	6.19	1	Yes	No	6	9	1	2
R:R:I112	R:R:W241	4.7	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:I112	4.34	1	Yes	Yes	0	6	0	1
R:R:H113	R:R:Y163	8.71	1	Yes	Yes	6	4	2	2
R:R:H113	R:R:H187	10.75	1	Yes	Yes	6	5	2	2
R:R:L183	R:R:Y163	8.21	0	No	Yes	5	4	2	2
R:R:H187	R:R:Y163	7.62	1	Yes	Yes	5	4	2	2
R:R:P167	R:R:W166	10.81	0	No	Yes	4	5	2	1
R:R:L183	R:R:W166	4.56	0	No	Yes	5	5	2	1
R:R:R244	R:R:W166	4	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:W166	18.17	1	Yes	Yes	0	5	0	1
R:R:P167	R:R:Y174	4.17	0	No	No	4	6	2	2
R:R:I169	R:R:W170	16.44	1	Yes	No	4	2	1	2
R:R:I169	R:R:Y174	9.67	1	Yes	No	4	6	1	2
R:R:H251	R:R:I169	5.3	1	No	Yes	4	4	1	1
L:L:?1	R:R:I169	10.84	1	Yes	Yes	0	4	0	1
R:R:H187	R:R:V191	9.69	1	Yes	No	5	5	2	2
R:R:H187	R:R:R244	9.03	1	Yes	Yes	5	5	2	1
R:R:V191	R:R:W241	11.03	0	No	Yes	5	8	2	1
R:R:F237	R:R:W241	7.02	1	Yes	Yes	9	8	2	1
R:R:F237	R:R:N277	8.46	1	Yes	No	9	9	2	2
R:R:R244	R:R:W241	5	1	Yes	Yes	5	8	1	1
R:R:A274	R:R:W241	9.08	0	No	Yes	7	8	2	1
R:R:N277	R:R:W241	7.91	1	No	Yes	9	8	2	1
L:L:?1	R:R:W241	4.33	1	Yes	Yes	0	8	0	1
R:R:I248	R:R:R244	3.76	1	No	Yes	5	5	1	1
R:R:N271	R:R:R244	9.64	1	No	Yes	6	5	1	1
L:L:?1	R:R:R244	27.68	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I248	4.34	1	Yes	No	0	5	0	1
R:R:H251	R:R:N259	3.83	1	No	No	4	2	1	2
L:L:?1	R:R:H251	11.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:S267	6.84	1	Yes	No	0	4	0	1
L:L:?1	R:R:N271	10.43	1	Yes	No	0	6	0	1
L:L:?1	R:R:L275	7.36	1	Yes	Yes	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VUH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	266
Number of Links	292
Number of Hubs	29
Number of Links mediated by Hubs	114
Number of Communities	3
Number of Nodes involved in Communities	37
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	125
Number Of Links MetaPath	124
Number of Shortest Paths	48026
Length Of Smallest Path	3
Average Path Length	13.0582
Length of Longest Path	26
Minimum Path Strength	1.21
Average Path Strength	6.25952
Maximum Path Strength	18.355
Minimum Path Correlation	0.7
Average Path Correlation	0.927504
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.6904
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.4965
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• xylanase activity • hydrolase activity, acting on glycosyl bonds • endo-1,4-beta-xylanase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • hydrolase activity • catalytic activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • identical protein binding • protein binding • binding • carbohydrate metabolic process • xylan catabolic process • catabolic process • carbohydrate catabolic process • hemicellulose catabolic process • primary metabolic process • macromolecule catabolic process • xylan metabolic process • polysaccharide metabolic process • polysaccharide catabolic process • metabolic process • cellular process • macromolecule metabolic process • cellular response to stimulus
Gene Ontology	Biological Process	• carbohydrate metabolic process • xylan catabolic process • catabolic process • carbohydrate catabolic process • hemicellulose catabolic process • primary metabolic process • macromolecule catabolic process • xylan metabolic process • polysaccharide metabolic process • polysaccharide catabolic process • metabolic process • cellular process • macromolecule metabolic process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7ZQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7ZQ
Name	3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Synonyms
Identifier
Formula	C17 H17 Cl N2 O2
Molecular Weight	316.782
SMILES
PubChem	2548547
Formal Charge	0
Total Atoms	39
Total Chiral Atoms	1
Total Bonds	40
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6DWJ6
Sequence	>7VUH_nogp_Chain_R C G L G F V P V V Y Y S L L L C L G L P A N I L T V I I L S Q L V A R R Q K S V Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L N M Q M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H P L K Y H T V S Y P A R T R K V I V S V Y I T C F L T S I P Y Y W W P N I W T E D Y I S T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K S N F R L R G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G A P I Q N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R F R T M A A A T L K A F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VUG	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	Gi1/β1/γ2	3.2	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUG (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.2	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUH	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	chim(Gs-CtGq)/β1/γ2	3.22	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUH (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.22	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUI	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP	chim(Gs-CtGq)/β1/γ2	3.3	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUI (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP		3.3	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUJ	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP	chim(Gs-CtGq)/β1/γ2	3.8	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUJ (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP		3.8	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	9M42	A	Orphan	Orphan	GPR139	Homo sapiens	A1L8O	-	chim(Gs-CtGq)/β1/γ2	3.2	2026-01-21	10.1038/s41467-025-66845-y
	9M42 (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	A1L8O	-		3.2	2026-01-21	10.1038/s41467-025-66845-y

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