psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F27	R:R:V30	6.55	No	No	0	3	4
2	R:R:P29	R:R:V28	3.53	No	No	0	5	4
3	R:R:D268	R:R:P29	6.44	No	No	0	5	5
4	R:R:F90	R:R:V30	6.55	No	No	0	4	4
5	R:R:Y32	R:R:Y33	5.96	Yes	Yes	4	5	7
6	R:R:L36	R:R:Y32	3.52	No	Yes	0	7	5
7	R:R:M272	R:R:Y32	10.78	Yes	Yes	4	6	5
8	R:R:L276	R:R:Y32	7.03	No	Yes	0	6	5
9	R:R:V81	R:R:Y33	6.31	No	Yes	0	7	7
10	R:R:F85	R:R:Y33	10.32	No	Yes	0	5	7
11	R:R:M272	R:R:Y33	8.38	Yes	Yes	4	6	7
12	R:R:A279	R:R:L36	3.15	No	No	0	7	7
13	R:R:L37	R:R:V81	7.45	No	No	0	7	7
14	R:R:L41	R:R:P42	3.28	No	No	0	7	4
15	R:R:A43	R:R:F282	4.16	No	Yes	0	8	9
16	R:R:D73	R:R:N44	12.12	No	No	0	9	9
17	R:R:F282	R:R:N44	3.62	Yes	No	0	9	9
18	R:R:I45	R:R:I74	4.42	No	No	0	4	7
19	R:R:I50	R:R:L46	4.28	Yes	No	0	8	6
20	R:R:L51	R:R:T47	2.95	No	Yes	0	7	8
21	R:R:F282	R:R:T47	7.78	Yes	Yes	3	9	8
22	R:R:C286	R:R:T47	3.38	No	Yes	3	7	8
23	R:R:F292	R:R:T47	7.78	No	Yes	3	9	8
24	R:R:F292	R:R:I50	3.77	No	Yes	0	9	8
25	R:R:I50	R:R:T299	4.56	Yes	No	0	8	5
26	R:R:L51	R:R:L67	5.54	No	No	0	7	6
27	R:R:L67	R:R:S52	4.5	No	No	0	6	4
28	R:R:R57	R:R:R58	4.26	No	No	0	7	6
29	R:R:N64	R:R:R57	4.82	No	No	0	5	7
30	R:R:K60	R:R:Y63	4.78	No	Yes	0	7	8
31	R:R:S61	R:R:Y65	6.36	No	Yes	2	7	8
32	R:R:S140	R:R:S61	3.26	Yes	No	2	8	7
33	R:R:S61	R:R:T145	6.4	No	No	2	7	8
34	R:R:V62	R:R:Y63	3.79	No	Yes	0	8	8
35	R:R:R291	R:R:Y63	7.2	No	Yes	0	7	8
36	R:R:N64	R:R:T145	4.39	No	No	0	5	8
37	R:R:L122	R:R:Y65	3.52	No	Yes	0	8	8
38	R:R:T145	R:R:Y65	11.24	No	Yes	2	8	8
39	R:R:V148	R:R:Y65	3.79	No	Yes	0	6	8
40	R:R:C286	R:R:L66	4.76	No	No	0	7	9
41	R:R:A68	R:R:I118	4.87	No	Yes	0	8	7
42	R:R:A68	R:R:I149	3.25	No	No	0	8	7
43	R:R:I118	R:R:L69	5.71	Yes	No	0	7	9
44	R:R:L69	R:R:T119	4.42	No	No	0	9	8
45	R:R:L69	R:R:N281	8.24	No	No	0	9	9
46	R:R:F79	R:R:L75	6.09	No	No	0	4	6
47	R:R:L75	R:R:S111	6.01	No	No	0	6	7
48	R:R:L77	R:R:V76	2.98	No	Yes	5	7	7
49	R:R:I80	R:R:V76	3.07	Yes	Yes	0	6	7
50	R:R:T278	R:R:V76	6.35	No	Yes	5	8	7
51	R:R:L77	R:R:T278	2.95	No	No	5	7	8
52	R:R:F78	R:R:F79	5.36	No	No	0	5	4
53	R:R:E108	R:R:I80	5.47	No	Yes	0	5	6
54	L:L:?1	R:R:I80	4.34	Yes	Yes	0	0	6
55	R:R:L275	R:R:V81	2.98	No	No	0	6	7
56	R:R:F82	R:R:V83	3.93	No	No	0	7	6
57	R:R:F82	R:R:L87	3.65	No	No	0	7	4
58	R:R:D84	R:R:F85	8.36	No	No	0	4	5
59	R:R:D84	R:R:E88	9.09	No	No	0	4	3
60	R:R:D84	R:R:E108	11.69	No	No	0	4	5
61	L:L:?1	R:R:F85	4.63	Yes	No	0	0	5
62	R:R:F90	R:R:L86	6.09	No	No	0	4	4
63	R:R:L87	R:R:L92	5.54	No	No	0	4	3
64	R:R:E88	R:R:N93	6.57	No	No	0	3	4
65	R:R:D89	R:R:F90	7.17	No	No	0	3	4
66	R:R:L92	R:R:Q95	7.99	No	No	0	3	4
67	R:R:P100	R:R:Q95	6.32	No	No	0	4	4
68	R:R:M96	R:R:P100	6.71	No	No	0	5	4
69	R:R:P100	R:R:V99	7.07	No	No	0	4	1
70	R:R:K102	R:R:Y164	17.91	No	Yes	0	6	5
71	R:R:I103	R:R:Y164	4.84	No	Yes	0	4	5
72	R:R:E108	R:R:I104	4.1	No	No	0	5	4
73	R:R:E105	R:R:F109	8.16	No	Yes	1	4	5
74	R:R:E105	R:R:W166	11.99	No	Yes	1	4	5
75	R:R:F109	R:R:Y163	11.35	Yes	Yes	1	5	4
76	R:R:F109	R:R:W166	20.04	Yes	Yes	1	5	5
77	L:L:?1	R:R:F109	3.7	Yes	Yes	1	0	5
78	R:R:F157	R:R:S110	14.53	No	No	0	4	5
79	R:R:S110	R:R:S160	6.52	No	No	0	5	7
80	R:R:C156	R:R:H113	2.95	No	Yes	0	7	6
81	R:R:H113	R:R:Y163	8.71	Yes	Yes	1	6	4
82	R:R:H113	R:R:H187	3.58	Yes	Yes	1	6	5
83	R:R:H113	R:R:T190	6.85	Yes	No	0	6	4
84	R:R:T114	R:R:Y153	11.24	No	No	0	6	7
85	R:R:C156	R:R:T114	5.07	No	No	0	7	6
86	R:R:I116	R:R:V191	3.07	No	No	0	7	5
87	R:R:I116	R:R:P195	3.39	No	No	0	7	9
88	R:R:F237	R:R:I116	3.77	Yes	No	0	9	7
89	R:R:V120	R:R:W117	7.36	Yes	No	0	8	7
90	R:R:T190	R:R:W117	3.64	No	No	0	4	7
91	R:R:I118	R:R:V152	3.07	Yes	No	0	7	7
92	R:R:I118	R:R:Y153	3.63	Yes	No	0	7	7
93	R:R:F199	R:R:T119	5.19	Yes	No	0	8	8
94	R:R:T119	R:R:Y285	3.75	No	Yes	0	8	9
95	R:R:P121	R:R:V120	3.53	No	Yes	0	7	8
96	R:R:P195	R:R:V120	3.53	No	Yes	0	9	8
97	R:R:I198	R:R:V120	4.61	No	Yes	0	6	8
98	R:R:F199	R:R:V120	6.55	Yes	Yes	0	8	8
99	R:R:L122	R:R:Y285	4.69	No	Yes	0	8	9
100	R:R:R126	R:R:T123	6.47	No	No	0	9	9
101	R:R:F199	R:R:T123	9.08	Yes	No	0	8	9
102	R:R:L202	R:R:T123	2.95	No	No	0	7	9
103	R:R:D125	R:R:Y136	11.49	No	Yes	2	9	7
104	R:R:D125	R:R:S140	4.42	No	Yes	2	9	8
105	R:R:L230	R:R:R126	4.86	No	No	0	8	9
106	R:R:R126	R:R:Y285	3.09	No	Yes	0	9	9
107	R:R:I128	R:R:Y127	3.63	No	Yes	0	7	8
108	R:R:C131	R:R:Y127	6.72	Yes	Yes	6	7	8
109	R:R:L202	R:R:Y127	8.21	No	Yes	0	7	8
110	R:R:I205	R:R:Y127	4.84	No	Yes	0	5	8
111	R:R:I206	R:R:Y127	8.46	No	Yes	6	8	8
112	R:R:A129	R:R:Y136	9.34	No	Yes	0	8	7
113	R:R:L210	R:R:V130	4.47	No	No	0	8	8
114	R:R:C131	R:R:H132	4.42	Yes	No	0	7	7
115	R:R:C131	R:R:I206	3.27	Yes	No	6	7	8
116	R:R:C131	R:R:K209	12.93	Yes	No	0	7	5
117	R:R:H137	R:R:Y136	7.62	No	Yes	0	5	7
118	R:R:S140	R:R:Y136	7.63	Yes	Yes	2	8	7
119	R:R:R144	R:R:Y141	21.61	No	No	0	6	8
120	R:R:I161	R:R:P162	3.39	No	No	0	5	7
121	R:R:W166	R:R:Y163	4.82	Yes	Yes	1	5	4
122	R:R:H187	R:R:Y163	7.62	Yes	Yes	1	5	4
123	R:R:W165	R:R:Y164	7.72	No	Yes	0	5	5
124	R:R:P167	R:R:W166	9.46	No	Yes	0	4	5
125	R:R:I184	R:R:W166	4.7	No	Yes	0	4	5
126	R:R:H187	R:R:W166	5.29	Yes	Yes	1	5	5
127	L:L:?1	R:R:W166	3.46	Yes	Yes	1	0	5
128	R:R:P167	R:R:Y174	5.56	No	No	0	4	6
129	R:R:H180	R:R:P167	19.83	No	No	0	4	4
130	R:R:N168	R:R:T171	8.77	No	No	0	3	1
131	R:R:I169	R:R:W170	9.4	Yes	Yes	1	4	2
132	R:R:I169	R:R:Y174	6.04	Yes	No	1	4	6
133	R:R:H251	R:R:I169	3.98	No	Yes	1	4	4
134	L:L:?1	R:R:I169	21.68	Yes	Yes	1	0	4
135	R:R:Q258	R:R:W170	6.57	No	Yes	1	1	2
136	R:R:V263	R:R:W170	6.13	No	Yes	1	3	2
137	R:R:H264	R:R:W170	15.87	No	Yes	0	3	2
138	R:R:S267	R:R:W170	6.18	No	Yes	0	4	2
139	R:R:H251	R:R:Y174	8.71	No	No	1	4	6
140	R:R:I175	R:R:T177	3.04	No	No	0	2	1
141	R:R:T177	R:R:V179	4.76	No	No	7	1	4
142	R:R:H180	R:R:T177	15.06	No	No	7	4	1
143	R:R:H180	R:R:V179	4.15	No	No	7	4	4
144	R:R:L183	R:R:V179	2.98	No	No	0	5	4
145	R:R:H181	R:R:L252	3.86	No	Yes	0	2	5
146	R:R:I184	R:R:I248	4.42	No	No	0	4	5
147	R:R:I184	R:R:L252	4.28	No	Yes	0	4	5
148	R:R:F189	R:R:W185	7.02	No	No	0	4	4
149	R:R:L249	R:R:W185	12.53	No	No	0	5	4
150	R:R:L252	R:R:W185	3.42	Yes	No	0	5	4
151	R:R:H187	R:R:V191	9.69	Yes	No	0	5	5
152	R:R:H187	R:R:R244	4.51	Yes	Yes	1	5	5
153	R:R:C188	R:R:I245	8.18	No	No	0	5	7
154	R:R:C188	R:R:I248	3.27	No	No	0	5	5
155	R:R:F189	R:R:L193	7.31	No	No	0	4	4
156	R:R:V191	R:R:W241	11.03	No	Yes	0	5	8
157	R:R:L193	R:R:Y192	3.52	No	Yes	0	4	7
158	R:R:C196	R:R:Y192	13.44	No	Yes	0	6	7
159	R:R:I245	R:R:Y192	4.84	No	Yes	0	7	7
160	R:R:P195	R:R:V194	3.53	No	No	0	9	5
161	R:R:F199	R:R:F237	5.36	Yes	Yes	0	8	9
162	R:R:F200	R:R:T234	10.38	No	No	0	5	8
163	R:R:L230	R:R:N203	6.87	No	No	0	8	9
164	R:R:N203	R:R:T234	4.39	No	No	0	9	8
165	R:R:T227	R:R:V207	7.93	No	No	0	8	6
166	R:R:F231	R:R:V207	6.55	No	No	0	6	6
167	R:R:R212	R:R:Y208	18.52	No	No	0	5	3
168	R:R:F216	R:R:L218	4.87	No	No	0	4	4
169	R:R:F216	R:R:R219	4.28	No	No	0	4	4
170	R:R:R219	R:R:S222	15.81	No	No	0	4	5
171	R:R:I229	R:R:K225	5.82	No	No	0	8	7
172	R:R:L230	R:R:T226	2.95	No	No	0	8	7
173	R:R:I233	R:R:L284	9.99	Yes	No	0	8	8
174	R:R:I233	R:R:Y285	7.25	Yes	Yes	0	8	9
175	R:R:I236	R:R:L240	4.28	No	No	0	6	8
176	R:R:I236	R:R:I280	4.42	No	No	0	6	6
177	R:R:F237	R:R:W241	4.01	Yes	Yes	1	9	8
178	R:R:F237	R:R:N277	6.04	Yes	No	1	9	9
179	R:R:L240	R:R:L273	5.54	No	No	0	8	8
180	R:R:L240	R:R:N277	9.61	No	No	0	8	9
181	R:R:R244	R:R:W241	7	Yes	Yes	1	5	8
182	R:R:A274	R:R:W241	7.78	No	Yes	0	7	8
183	R:R:N277	R:R:W241	7.91	No	Yes	1	9	8
184	R:R:L273	R:R:P243	4.93	No	No	0	8	8
185	R:R:N271	R:R:R244	4.82	No	Yes	1	6	5
186	L:L:?1	R:R:R244	20.3	Yes	Yes	1	0	5
187	R:R:M247	R:R:M266	4.33	No	No	0	4	4
188	R:R:M247	R:R:S267	6.13	No	No	0	4	4
189	R:R:A270	R:R:M247	3.22	No	No	0	6	4
190	L:L:?1	R:R:I248	8.67	Yes	No	0	0	5
191	L:L:?1	R:R:H251	5.86	Yes	No	1	0	4
192	R:R:L252	R:R:Y253	4.69	Yes	No	0	5	4
193	R:R:I257	R:R:N259	7.08	No	No	0	1	2
194	R:R:Q258	R:R:V263	4.3	No	No	1	1	3
195	R:R:R260	R:R:W261	8	No	No	0	1	2
196	R:R:I265	R:R:W261	4.7	No	No	0	3	2
197	R:R:D268	R:R:M272	6.93	No	Yes	0	5	6
198	L:L:?1	R:R:N271	14.6	Yes	No	1	0	6
199	R:R:N281	R:R:Y285	12.79	No	Yes	0	9	9
200	R:R:F282	R:R:F283	6.43	Yes	No	0	9	6
201	R:R:C286	R:R:F282	6.98	No	Yes	3	7	9
202	R:R:F282	R:R:F292	4.29	Yes	No	3	9	9
203	R:R:R291	R:R:S289	9.22	No	No	0	7	9
204	R:R:M295	R:R:T294	4.52	No	No	0	6	4
205	R:R:K301	R:R:L300	4.23	No	No	0	4	5
206	R:R:F303	R:R:F304	6.43	No	No	0	2	2
207	R:R:I49	R:R:I50	2.94	No	Yes	0	5	8
208	R:R:I112	R:R:I80	2.94	No	Yes	0	6	6
209	R:R:I201	R:R:I205	2.94	No	No	0	5	5
210	R:R:I229	R:R:I233	2.94	No	Yes	0	8	8
211	R:R:I269	R:R:M272	2.92	No	Yes	0	5	6
212	R:R:D73	R:R:T278	2.89	No	No	0	9	8
213	R:R:I74	R:R:L41	2.85	No	No	0	7	7
214	R:R:I74	R:R:N44	2.83	No	No	0	7	9
215	R:R:H181	R:R:S178	2.79	No	No	0	2	1
216	R:R:P162	R:R:Y163	2.78	No	Yes	0	7	4
217	R:R:H181	R:R:V182	2.77	No	No	0	2	4
218	R:R:A238	R:R:F200	2.77	No	No	0	6	5
219	R:R:L262	R:R:N259	2.75	No	No	0	3	2
220	R:R:A143	R:R:Y141	2.67	No	No	0	4	8
221	R:R:A242	R:R:Y192	2.67	No	Yes	0	5	7
222	R:R:R217	R:R:S214	2.64	No	No	0	6	5
223	R:R:D173	R:R:E172	2.6	No	No	0	3	4
224	R:R:R211	R:R:T223	2.59	No	Yes	0	4	6
225	R:R:V106	R:R:Y164	2.52	No	Yes	0	5	5
226	R:R:F283	R:R:L39	2.44	No	No	0	6	6
227	R:R:I186	R:R:Y163	2.42	No	Yes	0	4	4
228	R:R:L51	R:R:Y63	2.34	No	Yes	0	7	8
229	R:R:L54	R:R:Y63	2.34	No	Yes	0	5	8
230	R:R:A255	R:R:P256	1.87	No	No	0	1	1
231	R:R:G224	R:R:T223	1.82	No	Yes	0	4	6
232	R:R:C156	R:R:S110	1.72	No	No	0	7	5
233	R:R:C196	R:R:S197	1.72	No	No	0	6	3
234	R:R:G40	R:R:L39	1.71	No	No	0	9	6
235	R:R:G40	R:R:L77	1.71	No	No	0	9	7
236	R:R:A72	R:R:S115	1.71	No	No	0	8	9
237	R:R:A70	R:R:V48	1.7	No	No	0	9	7
238	R:R:A70	R:R:T47	1.68	No	Yes	0	9	8
239	R:R:A72	R:R:T114	1.68	No	No	0	8	6
240	R:R:M96	R:R:P97	1.68	No	No	0	5	6
241	R:R:A302	R:R:T299	1.68	No	No	0	5	5
242	R:R:S111	R:R:V76	1.62	No	Yes	0	7	7
243	R:R:S160	R:R:V106	1.62	No	No	0	7	5
244	R:R:S140	R:R:V139	1.62	Yes	No	0	8	4
245	R:R:A242	R:R:I246	1.62	No	No	0	5	6
246	R:R:A56	R:R:K60	1.61	No	No	0	7	7
247	R:R:D101	R:R:P97	1.61	No	No	0	9	6
248	R:R:S222	R:R:T223	1.6	No	Yes	0	5	6
249	R:R:S235	R:R:T239	1.6	No	No	0	5	5
250	R:R:A297	R:R:L300	1.58	No	No	0	3	5
251	R:R:T155	R:R:T159	1.57	No	No	0	3	4
252	R:R:T223	R:R:T227	1.57	Yes	No	0	6	8
253	R:R:T226	R:R:T227	1.57	No	No	0	7	8
254	R:R:I205	R:R:S204	1.55	No	No	0	5	4
255	R:R:I104	R:R:V83	1.54	No	No	0	4	6
256	R:R:I124	R:R:V120	1.54	No	Yes	0	6	8
257	R:R:I206	R:R:V130	1.54	No	No	0	8	8
258	R:R:I149	R:R:V150	1.54	No	No	0	7	4
259	R:R:H132	R:R:P133	1.53	No	No	0	7	8
260	R:R:I233	R:R:T232	1.52	Yes	No	0	8	5
261	R:R:F27	R:R:G26	1.51	No	No	0	3	3
262	R:R:N215	R:R:S222	1.49	No	No	0	4	5
263	R:R:I50	R:R:M295	1.46	Yes	No	0	8	6
264	R:R:G254	R:R:Y253	1.45	No	No	0	3	4
265	R:R:I91	R:R:L87	1.43	No	No	0	3	4
266	R:R:Q98	R:R:V99	1.43	No	No	0	4	1
267	R:R:I103	R:R:L107	1.43	No	No	0	4	5
268	R:R:K135	R:R:L134	1.41	No	No	0	5	6
269	R:R:P142	R:R:Y141	1.39	No	No	0	3	8
270	R:R:A71	R:R:Y153	1.33	No	No	0	6	7
271	R:R:R58	R:R:V55	1.31	No	No	0	6	4
272	R:R:R144	R:R:V139	1.31	No	No	0	6	4
273	R:R:D89	R:R:E88	1.3	No	No	0	3	3
274	R:R:I149	R:R:R146	1.25	No	No	0	7	5
275	R:R:L218	R:R:R217	1.21	No	No	0	4	6
276	R:R:F287	R:R:R293	1.07	No	No	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y32	6.8225	4	4	5
2	R:R:Y33	7.7425	4	4	7
3	R:R:T47	4.714	5	3	8
4	R:R:I50	3.402	5	0	8
5	R:R:Y63	4.09	5	0	8
6	R:R:Y65	6.2275	4	2	8
7	R:R:V76	3.505	4	5	7
8	R:R:I80	3.955	4	0	6
9	R:R:F109	10.8125	4	1	5
10	R:R:H113	5.5225	4	1	6
11	R:R:I118	4.32	4	0	7
12	R:R:V120	4.52	6	0	8
13	R:R:Y127	6.372	5	6	8
14	R:R:C131	6.835	4	6	7
15	R:R:Y136	9.02	4	2	7
16	R:R:S140	4.2325	4	2	8
17	R:R:Y163	6.28333	6	1	4
18	R:R:Y164	8.2475	4	0	5
19	R:R:W166	8.53714	7	1	5
20	R:R:I169	10.275	4	1	4
21	R:R:W170	8.83	5	1	2
22	R:R:H187	6.138	5	1	5
23	R:R:Y192	6.1175	4	0	7
24	R:R:F199	6.545	4	0	8
25	R:R:T223	1.895	4	0	6
26	R:R:I233	5.425	4	0	8
27	R:R:F237	4.795	4	1	9
28	R:R:W241	7.546	5	1	8
29	R:R:R244	9.1575	4	1	5
30	R:R:L252	4.0625	4	0	5
31	R:R:M272	7.2525	4	4	6
32	R:R:F282	5.54333	6	3	9
33	R:R:Y285	6.314	5	0	9
34	L:L:?1	9.69333	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D89	R:R:F90	10.8708	7.17	No	No	0	3	4
2	R:R:D89	R:R:E88	13.0071	1.3	No	No	0	3	3
3	R:R:D84	R:R:E88	17.2405	9.09	No	No	0	4	3
4	R:R:D84	R:R:F85	17.2666	8.36	No	No	0	4	5
5	R:R:F85	R:R:Y33	27.5952	10.32	No	Yes	0	5	7
6	R:R:M272	R:R:Y33	10.7402	8.38	Yes	Yes	4	6	7
7	R:R:E108	R:R:I80	30.0516	5.47	No	Yes	0	5	6
8	R:R:I80	R:R:V76	79.5453	3.07	Yes	Yes	0	6	7
9	R:R:T278	R:R:V76	63.128	6.35	No	Yes	5	8	7
10	R:R:D73	R:R:T278	61.6123	2.89	No	No	0	9	8
11	R:R:D73	R:R:N44	59.8223	12.12	No	No	0	9	9
12	R:R:F282	R:R:N44	50.7415	3.62	Yes	No	0	9	9
13	R:R:F282	R:R:F292	16.6133	4.29	Yes	No	3	9	9
14	R:R:F292	R:R:I50	15.2675	3.77	No	Yes	0	9	8
15	R:R:F282	R:R:T47	26.8309	7.78	Yes	Yes	3	9	8
16	R:R:L51	R:R:T47	21.4869	2.95	No	Yes	0	7	8
17	L:L:?1	R:R:F85	42.6929	4.63	Yes	No	0	0	5
18	L:L:?1	R:R:R244	93.6369	20.3	Yes	Yes	1	0	5
19	R:R:R244	R:R:W241	86.9863	7	Yes	Yes	1	5	8
20	R:R:F237	R:R:W241	86.6336	4.01	Yes	Yes	1	9	8
21	R:R:F199	R:R:F237	97.2888	5.36	Yes	Yes	0	8	9
22	R:R:F199	R:R:T119	49.2389	5.19	Yes	No	0	8	8
23	R:R:T119	R:R:Y285	45.5478	3.75	No	Yes	0	8	9
24	R:R:L122	R:R:Y285	39.0932	4.69	No	Yes	0	8	9
25	R:R:L122	R:R:Y65	37.1529	3.52	No	Yes	0	8	8
26	R:R:T145	R:R:Y65	10.3809	11.24	No	Yes	2	8	8
27	R:R:L51	R:R:Y63	15.1761	2.34	No	Yes	0	7	8
28	R:R:S61	R:R:Y65	22.8458	6.36	No	Yes	2	7	8
29	R:R:S140	R:R:S61	21.1603	3.26	Yes	No	2	8	7
30	R:R:A68	R:R:I118	18.5209	4.87	No	Yes	0	8	7
31	R:R:I118	R:R:L69	19.3376	5.71	Yes	No	0	7	9
32	R:R:L69	R:R:T119	15.4831	4.42	No	No	0	9	8
33	R:R:I118	R:R:Y153	29.1762	3.63	Yes	No	0	7	7
34	R:R:T114	R:R:Y153	33.7885	11.24	No	No	0	6	7
35	R:R:C156	R:R:T114	41.3536	5.07	No	No	0	7	6
36	R:R:C156	R:R:H113	69.0534	2.95	No	Yes	0	7	6
37	R:R:H113	R:R:H187	39.041	3.58	Yes	Yes	1	6	5
38	R:R:H187	R:R:R244	31.0904	4.51	Yes	Yes	1	5	5
39	R:R:H113	R:R:Y163	38.956	8.71	Yes	Yes	1	6	4
40	R:R:F109	R:R:Y163	18.6059	11.35	Yes	Yes	1	5	4
41	L:L:?1	R:R:F109	20.422	3.7	Yes	Yes	1	0	5
42	R:R:W166	R:R:Y163	24.0086	4.82	Yes	Yes	1	5	4
43	L:L:?1	R:R:W166	56.4317	3.46	Yes	Yes	1	0	5
44	R:R:H187	R:R:W166	50.2972	5.29	Yes	Yes	1	5	5
45	R:R:A68	R:R:I149	13.9087	3.25	No	No	0	8	7
46	R:R:E108	R:R:I104	27.5952	4.1	No	No	0	5	4
47	R:R:I104	R:R:V83	25.5504	1.54	No	No	0	4	6
48	R:R:F82	R:R:V83	23.4925	3.93	No	No	0	7	6
49	R:R:F82	R:R:L87	21.4216	3.65	No	No	0	7	4
50	R:R:L87	R:R:L92	17.2405	5.54	No	No	0	4	3
51	R:R:L92	R:R:Q95	15.1303	7.99	No	No	0	3	4
52	R:R:P100	R:R:Q95	13.0071	6.32	No	No	0	4	4
53	R:R:C156	R:R:S110	37.2117	1.72	No	No	0	7	5
54	R:R:S110	R:R:S160	29.0325	6.52	No	No	0	5	7
55	R:R:S160	R:R:V106	24.9232	1.62	No	No	0	7	5
56	R:R:V106	R:R:Y164	20.8009	2.52	No	Yes	0	5	5
57	R:R:H113	R:R:T190	12.4453	6.85	Yes	No	0	6	4
58	R:R:H187	R:R:V191	28.7058	9.69	Yes	No	0	5	5
59	R:R:I116	R:R:V191	17.7566	3.07	No	No	0	7	5
60	R:R:V191	R:R:W241	14.9801	11.03	No	Yes	0	5	8
61	R:R:F237	R:R:I116	12.8634	3.77	Yes	No	0	9	7
62	R:R:F199	R:R:V120	11.0276	6.55	Yes	Yes	0	8	8
63	R:R:F199	R:R:T123	54.2693	9.08	Yes	No	0	8	9
64	R:R:R126	R:R:T123	35.4282	6.47	No	No	0	9	9
65	R:R:L202	R:R:T123	25.3871	2.95	No	No	0	7	9
66	R:R:L230	R:R:R126	40.3345	4.86	No	No	0	8	9
67	R:R:L202	R:R:Y127	23.5121	8.21	No	Yes	0	7	8
68	R:R:S140	R:R:V139	10.7402	1.62	Yes	No	0	8	4
69	R:R:P167	R:R:W166	18.9978	9.46	No	Yes	0	4	5
70	R:R:I184	R:R:W166	34.0236	4.7	No	Yes	0	4	5
71	L:L:?1	R:R:I248	28.1179	8.67	Yes	No	0	0	5
72	R:R:I184	R:R:I248	14.4378	4.42	No	No	0	4	5
73	L:L:?1	R:R:I169	19.919	21.68	Yes	Yes	1	0	4
74	R:R:H180	R:R:P167	15.7706	19.83	No	No	0	4	4
75	R:R:I169	R:R:W170	17.1882	9.4	Yes	Yes	1	4	2
76	R:R:I184	R:R:L252	37.5906	4.28	No	Yes	0	4	5
77	R:R:H181	R:R:L252	12.5955	3.86	No	Yes	0	2	5
78	R:R:L252	R:R:W185	13.2096	3.42	Yes	No	0	5	4
79	R:R:C188	R:R:I248	18.4164	3.27	No	No	0	5	5
80	R:R:C188	R:R:I245	15.96	8.18	No	No	0	5	7
81	R:R:I245	R:R:Y192	13.5167	4.84	No	Yes	0	7	7
82	R:R:L230	R:R:T226	30.1757	2.95	No	No	0	8	7
83	R:R:T226	R:R:T227	28.1048	1.57	No	No	0	7	8
84	R:R:R219	R:R:S222	11.0668	15.81	No	No	0	4	5
85	R:R:S222	R:R:T223	15.4047	1.6	No	Yes	0	5	6
86	R:R:T223	R:R:T227	21.8135	1.57	Yes	No	0	6	8
87	R:R:I233	R:R:Y285	10.7402	7.25	Yes	Yes	0	8	9
88	L:L:?1	R:R:I80	100	4.34	Yes	Yes	0	0	6
89	R:R:R126	R:R:Y285	11.6483	3.09	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F85	R:R:Y33	10.32	0	No	Yes	5	7	1	2
R:R:I80	R:R:V76	3.07	0	Yes	Yes	6	7	1	2
R:R:E108	R:R:I80	5.47	0	No	Yes	5	6	2	1
L:L:?1	R:R:I80	4.34	1	Yes	Yes	0	6	0	1
R:R:D84	R:R:F85	8.36	0	No	No	4	5	2	1
R:R:D84	R:R:E108	11.69	0	No	No	4	5	2	2
L:L:?1	R:R:F85	4.63	1	Yes	No	0	5	0	1
R:R:E105	R:R:F109	8.16	1	No	Yes	4	5	2	1
R:R:E105	R:R:W166	11.99	1	No	Yes	4	5	2	1
R:R:F109	R:R:Y163	11.35	1	Yes	Yes	5	4	1	2
R:R:F109	R:R:W166	20.04	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:F109	3.7	1	Yes	Yes	0	5	0	1
R:R:W166	R:R:Y163	4.82	1	Yes	Yes	5	4	1	2
R:R:H187	R:R:Y163	7.62	1	Yes	Yes	5	4	2	2
R:R:P167	R:R:W166	9.46	0	No	Yes	4	5	2	1
R:R:I184	R:R:W166	4.7	0	No	Yes	4	5	2	1
R:R:H187	R:R:W166	5.29	1	Yes	Yes	5	5	2	1
L:L:?1	R:R:W166	3.46	1	Yes	Yes	0	5	0	1
R:R:P167	R:R:Y174	5.56	0	No	No	4	6	2	2
R:R:I169	R:R:W170	9.4	1	Yes	Yes	4	2	1	2
R:R:I169	R:R:Y174	6.04	1	Yes	No	4	6	1	2
R:R:H251	R:R:I169	3.98	1	No	Yes	4	4	1	1
L:L:?1	R:R:I169	21.68	1	Yes	Yes	0	4	0	1
R:R:H251	R:R:Y174	8.71	1	No	No	4	6	1	2
R:R:I184	R:R:I248	4.42	0	No	No	4	5	2	1
R:R:H187	R:R:R244	4.51	1	Yes	Yes	5	5	2	1
R:R:C188	R:R:I248	3.27	0	No	No	5	5	2	1
R:R:R244	R:R:W241	7	1	Yes	Yes	5	8	1	2
R:R:N271	R:R:R244	4.82	1	No	Yes	6	5	1	1
L:L:?1	R:R:R244	20.3	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I248	8.67	1	Yes	No	0	5	0	1
L:L:?1	R:R:H251	5.86	1	Yes	No	0	4	0	1
L:L:?1	R:R:N271	14.6	1	Yes	No	0	6	0	1
R:R:I112	R:R:I80	2.94	0	No	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VUI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	258
Number of Links	276
Number of Hubs	34
Number of Links mediated by Hubs	132
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	45329
Length Of Smallest Path	3
Average Path Length	12.3552
Length of Longest Path	29
Minimum Path Strength	1.395
Average Path Strength	5.95618
Maximum Path Strength	20.99
Minimum Path Correlation	0.81
Average Path Correlation	0.981277
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	20
Average % Of Corr. Nodes	90.6541
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.6572
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • xylanase activity • hydrolase activity, acting on glycosyl bonds • endo-1,4-beta-xylanase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • identical protein binding • carbohydrate metabolic process • xylan catabolic process • catabolic process • carbohydrate catabolic process • hemicellulose catabolic process • primary metabolic process • macromolecule catabolic process • xylan metabolic process • polysaccharide metabolic process • polysaccharide catabolic process • metabolic process • macromolecule metabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GTP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GTP
Name	Guanosine-5'-Triphosphate
Synonyms	Guanosine-5'-Triphosphate
Identifier
Formula	C10 H16 N5 O14 P3
Molecular Weight	523.18
SMILES
PubChem	135398633
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	4
Total Bonds	50
Total Aromatic Bonds	5


Code	7ZQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7ZQ
Name	3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Synonyms
Identifier
Formula	C17 H17 Cl N2 O2
Molecular Weight	316.782
SMILES
PubChem	2548547
Formal Charge	0
Total Atoms	39
Total Chiral Atoms	1
Total Bonds	40
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6DWJ6
Sequence	>7VUI_nogp_Chain_R G F V P V V Y Y S L L L C L G L P A N I L T V I I L S Q L V A R R Q K S V Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L N M Q M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H P L K Y H T V S Y P A R T R K V I V S V Y I T C F L T S I P Y Y W W P N I W T E D Y I S T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K S N F R L R G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G A P I Q N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R F R T M A A A T L K A F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VUI	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP	chim(Gs-CtGq)/β1/γ2	3.3	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUI (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP		3.3	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUJ	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP	chim(Gs-CtGq)/β1/γ2	3.8	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUJ (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GDP		3.8	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUG	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	Gi1/β1/γ2	3.2	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUG (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.2	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUH	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-	chim(Gs-CtGq)/β1/γ2	3.22	2021-12-29	doi.org/10.1038/s41422-021-00591-w
	7VUH (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	-		3.22	2021-12-29	doi.org/10.1038/s41422-021-00591-w

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